Detailed information for compound 52799

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.696 | Formula: C30H36N4O4S
  • H donors: 3 H acceptors: 5 LogP: 4.94 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCc1ncc(o1)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)CCNC[C@@H](c1cccnc1)O
  • InChi: 1S/C30H36N4O4S/c1-2-3-4-5-8-30-33-22-29(38-30)24-11-15-27(16-12-24)39(36,37)34-26-13-9-23(10-14-26)17-19-32-21-28(35)25-7-6-18-31-20-25/h6-7,9-16,18,20,22,28,32,34-35H,2-5,8,17,19,21H2,1H3/t28-/m0/s1
  • InChiKey: CRWBQDZJYVFCLP-NDEPHWFRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.0457 0.0457
Chlamydia trachomatis leucine--tRNA ligase 0.0029 0.027 0.1095
Trypanosoma cruzi ISWI complex protein 0.0017 0.0068 0.0792
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0905 0.0905
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.0457 0.1497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.0239
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.0457 0.0457
Echinococcus granulosus orexin receptor type 2 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.0457 0.1497
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0154 0.2354 0.2354
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0852 0.2011
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0017 0.007 0.0056
Brugia malayi methionyl-tRNA synthetase 0.0163 0.2492 0.5862
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0014 0.0014 0.0014
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0029 0.027 0.0257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0028 0.0238 0.0562
Echinococcus granulosus tyrosyl tRNA synthetase 0.0014 0.0014 0.0014
Brugia malayi nuclear receptor RXR 0.0016 0.0051 0.0069
Brugia malayi Muscleblind-like protein 0.0169 0.2595 0.6105
Echinococcus multilocularis somatostatin receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0294 0.0947
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0113 0.1585
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0698 1
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0173 0.2665 1
Trypanosoma brucei unspecified product 0.0024 0.0185 0.1468
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.0457 0.0457
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Schistosoma mansoni rab6-interacting 0.0019 0.0097 0.0281
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0457 0.0457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0457 0.1497
Echinococcus granulosus bloom syndrome protein 0.002 0.0113 0.0113
Schistosoma mansoni neuropeptide receptor 0.0041 0.0457 0.1497
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0294 0.0645
Schistosoma mansoni neuropeptide receptor 0.0041 0.0457 0.1497
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0154 0.2042
Schistosoma mansoni survival motor neuron protein 0.0055 0.0689 0.228
Schistosoma mansoni myosin xvIII 0.0041 0.0457 0.1497
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0642 0.9187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0294 0.0294
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0205 0.0205
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0642 0.0642
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0022 0.0053
Leishmania major ribonuclease H1, putative 0.0022 0.0154 0.2042
Echinococcus multilocularis zinc finger protein 0.0022 0.0149 0.0149
Toxoplasma gondii tRNA ligases class I (M) protein 0.0024 0.0174 0.2554
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Treponema pallidum methionyl-tRNA synthetase 0.0163 0.2492 1
Schistosoma mansoni rab6-interacting 0.0019 0.0097 0.0281
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Echinococcus multilocularis RUN 0.0019 0.0097 0.0097
Echinococcus granulosus g-protein coupled receptor 0.0041 0.0457 0.0457
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0097 0.0097
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0113 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0852 0.2833
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0122
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0852 0.1969
Schistosoma mansoni hypothetical protein 0.0192 0.2973 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0113 0.1456
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.1112 0.2626
Onchocerca volvulus 0.0075 0.1022 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0457 0.0457
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0294 0.0947
Onchocerca volvulus 0.0041 0.0457 0.4344
Brugia malayi PHD-finger family protein 0.0028 0.0249 0.0538
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0457 0.1497
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0113 0.1456
Treponema pallidum leucyl-tRNA synthetase 0.0029 0.027 0.0499
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.0457 0.0457
Trypanosoma cruzi glutaminyl-tRNA synthetase, putative 0.0016 0.0043 0.0426
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0022 0.0022
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0689 0.1581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0122
Onchocerca volvulus 0.0041 0.0457 0.4344
Trypanosoma brucei ISWI complex protein 0.0017 0.0068 0.0464
Schistosoma mansoni amine GPCR 0.0041 0.0457 0.1497
Echinococcus multilocularis orexin receptor type 2 0.0041 0.0457 0.0457
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0236 0.0507
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.0457 0.1031
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.4236 0.4236
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0097 0.2602
Onchocerca volvulus 0.0021 0.0134 0.1114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0294 0.2718
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.002 0.0111 0.1425
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0457 0.0457
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0185 0.1468
Brugia malayi MAP kinase sur-1 0.0052 0.0642 0.1471
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.0457 0.0457
Echinococcus granulosus g protein coupled receptor 0.0041 0.0457 0.0457
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0027 0.023 0.1597
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0022 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0294 0.0294
Onchocerca volvulus 0.0019 0.0097 0.0747
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0022 0.0029
Schistosoma mansoni amine GPCR 0.0041 0.0457 0.1497
Entamoeba histolytica recQ family helicase, putative 0.002 0.0113 0.0402
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0095 0.1364 1
Chlamydia trachomatis methionine--tRNA ligase 0.0154 0.2354 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0457 0.0457
Schistosoma mansoni histamine h1 receptor 0.0041 0.0457 0.1497
Loa Loa (eye worm) hypothetical protein 0.0027 0.023 0.0542
Schistosoma mansoni hypothetical protein 0.0055 0.0689 0.228
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0055 0.0698 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0027 0.023 0.3432
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0159 0.2425 0.8149
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0255 0.3521
Brugia malayi Bromodomain containing protein 0.0085 0.1193 0.2778
Schistosoma mansoni bromodomain containing protein 0.0072 0.0972 0.3239
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.0457 0.1497
Brugia malayi larval opioid receptor 0.0041 0.0457 0.1031
Schistosoma mansoni hypothetical protein 0.0019 0.0097 0.0281
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0022 0.0029
Brugia malayi Dopamine receptor protein 1 0.0041 0.0457 0.1031
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0113 0.0216
Echinococcus granulosus muscleblind protein 0.0169 0.2595 0.2595
Brugia malayi G-protein coupled receptor 0.0041 0.0457 0.1031
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0113 0.0266
Brugia malayi hypothetical protein 0.0016 0.0051 0.0069
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0022 0.0022
Echinococcus granulosus fmrfamide receptor 0.0041 0.0457 0.0457
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0255 0.1595
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0642 0.0642
Echinococcus multilocularis geminin 0.0192 0.2973 0.2973
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0255 0.3833
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0097 0.0097
Echinococcus multilocularis musashi 0.0027 0.0236 0.0236
Schistosoma mansoni phosphoglucomutase 0.0022 0.0154 0.0472
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Onchocerca volvulus 0.0027 0.0236 0.2138
Echinococcus multilocularis lamin dm0 0.0027 0.0236 0.0236
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0294 0.0294
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0105 0.1524 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0294 0.0645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0294 0.0294
Brugia malayi protein ZK524.3 0.0028 0.0238 0.0512
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.0457 0.1497
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Toxoplasma gondii glutaminyl-tRNA synthetase (GlnRS) 0.0016 0.0043 0.0464
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0055 0.0698 0.0698
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0173 0.2665 0.2654
Trypanosoma brucei ribonuclease H1 0.0022 0.0154 0.1196
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0163 0.2492 1
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0024 0.0174 0.1375
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0457 0.0457
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0022 0.0022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0113 0.0268
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0139 0.2097 0.4952
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.0457 0.1031
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.4236 0.4236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0294 0.0294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0022 0.0022
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0027 0.023 0.3153
Brugia malayi RE15519p 0.0041 0.0457 0.1031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0457 0.0457
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0185 0.1468
Schistosoma mansoni DNA helicase recq1 0.002 0.0113 0.0337
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.0457 0.0457
Brugia malayi RNase H family protein 0.0022 0.0154 0.0311
Brugia malayi GnHR receptor homolog 0.0041 0.0457 0.1031
Schistosoma mansoni amine GPCR 0.0041 0.0457 0.1497
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0051 0.0127
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.0457 0.1031
Schistosoma mansoni lamin 0.0027 0.0236 0.0751
Echinococcus granulosus ribonuclease H1 0.0022 0.0154 0.0154
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0021 0.0134 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0852 0.2833
Loa Loa (eye worm) DR-78 0.0015 0.0022 0.0053
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0457 0.1078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0101 0.0295
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0294 0.0294
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0294 0.0694
Echinococcus granulosus geminin 0.0192 0.2973 0.2973
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.0457 0.1497
Brugia malayi isoleucyl-tRNA synthetase 0.0027 0.023 0.0492
Brugia malayi Serotonin receptor 0.0041 0.0457 0.1031
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0024 0.0174 0.2347
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0022 0.0022
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0173 0.2665 0.2654
Echinococcus multilocularis glycyl tRNA synthetase 0.005 0.0605 0.0605
Echinococcus multilocularis bloom syndrome protein 0.002 0.0113 0.0113
Echinococcus granulosus g protein coupled receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0294 0.0694
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0294 0.0947
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0642 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.0457 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0852 0.2833
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.1362 0.1362
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0457 0.0457
Schistosoma mansoni biogenic amine receptor 0.0041 0.0457 0.1497
Loa Loa (eye worm) hypothetical protein 0.0169 0.2595 0.6125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Brugia malayi follicle stimulating hormone receptor 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.2029 0.4791
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni intermediate filament proteins 0.0027 0.0236 0.0751
Loa Loa (eye worm) hypothetical protein 0.0048 0.0583 0.1377
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0027 0.023 0.1428
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.0457 0.1078
Schistosoma mansoni hypothetical protein 0.0084 0.1181 0.3946
Echinococcus multilocularis jun protein 0.0095 0.1362 0.1362
Schistosoma mansoni leucyl-tRNA synthetase 0.0033 0.0334 0.1081
Brugia malayi Melatonin receptor type 1A 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0229
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0294 0.0294
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0457 0.1078
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0113 0.066
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0101 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0294 0.0694
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0024 0.0174 0.0161
Schistosoma mansoni coup transcription factor 0.0031 0.0294 0.0947
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0113 0.0216
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0027 0.023 0.1847
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0698 0.276
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.2029 0.4791
Onchocerca volvulus 0.0041 0.0457 0.4344
Brugia malayi hypothetical protein 0.0075 0.1022 0.2373
Plasmodium vivax methionine--tRNA ligase, putative 0.0024 0.0174 0.5016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0022 0.0022
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0095 0.1364 0.1353
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0294 0.0645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0457 0.0457
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0668 0.0668
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0457 0.0457
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0294 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Schistosoma mansoni phosphoglucomutase 0.0022 0.0154 0.0472
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Brugia malayi hypothetical protein 0.0018 0.0086 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0852 0.2833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.0457 0.0457
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0041 0.0457 0.1497
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0113 0.0853
Schistosoma mansoni isoleucine--tRNA ligase 0.0027 0.023 0.0729
Schistosoma mansoni biogenic amine receptor 0.0041 0.0457 0.1497
Schistosoma mansoni adenoreceptor 0.0041 0.0457 0.1497
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0022 0.0029
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0457 0.0457
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0154 0.2042
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.2425 0.2425
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0642 0.2124
Schistosoma mansoni glycyl-tRNA synthetase 0.005 0.0605 0.1997
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0113 0.0113
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.0457 0.1497
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0642 0.1516
Schistosoma mansoni hypothetical protein 0.0077 0.1066 0.3555
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0457 0.1497
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0101 0.0295
Schistosoma mansoni opsin-like receptor 0.0041 0.0457 0.1497
Echinococcus multilocularis leucyl tRNA synthetase 0.0033 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.0457 0.0457
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0457 0.0457
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0024 0.0174 0.0161
Brugia malayi neuropeptide F receptor 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0122
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0022 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Schistosoma mansoni glutaminyl-tRNA synthetase (glutamine--tRNA ligase) (glnrs) 0.005 0.0616 0.2035
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.0457 0.1497
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0457 0.0457
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0113 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0027 0.023 0.0492
Brugia malayi Dopamine receptor 0.0041 0.0457 0.1031
Echinococcus granulosus jun protein 0.0095 0.1362 0.1362
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.0457 0.0457
Echinococcus multilocularis serotonin receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0294 0.0694
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni amine GPCR 0.0041 0.0457 0.1497
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0024 0.0174 0.2347
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0113 0.1456
Onchocerca volvulus 0.0041 0.0457 0.4344
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0154 0.2223
Echinococcus multilocularis thymidine phosphorylase 0.0613 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0294 0.0645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0294 0.2718
Echinococcus granulosus allatostatin A receptor 0.0041 0.0457 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0294 0.0645
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Leishmania major methionyl-tRNA synthetase, putative 0.0024 0.0174 0.2347
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0014 0.0014 0.0014
Giardia lamblia Isoleucyl-tRNA synthetase 0.0027 0.023 0.3153
Brugia malayi nuclear hormone receptor 0.0031 0.0294 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0294 0.0645
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Schistosoma mansoni biogenic amine receptor 0.0041 0.0457 0.1497
Brugia malayi Bromodomain containing protein 0.0043 0.0501 0.1137
Leishmania major isoleucyl-tRNA synthetase, putative 0.0027 0.023 0.3153
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0097 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.007 0.0824
Plasmodium falciparum methionine--tRNA ligase, putative 0.0024 0.0174 0.1063
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0316
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0642 0.9187
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0457 0.1078
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0113 0.1456
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0113 0.1585
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0097 0.0551
Schistosoma mansoni zinc finger protein 0.0015 0.0022 0.0029
Echinococcus multilocularis sex peptide receptor 0.0041 0.0457 0.0457
Schistosoma mansoni lamin 0.0027 0.0236 0.0751
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0638
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.0457 0.4344
Schistosoma mansoni nuclear receptor 0.0015 0.0022 0.0029
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0027 0.023 0.0542
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1911 0.1911
Echinococcus granulosus lamin dm0 0.0027 0.0236 0.0236
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.0618
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0294 0.0294
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.0457 0.0457
Echinococcus granulosus g protein coupled receptor 0.0041 0.0457 0.0457
Trypanosoma brucei glutaminyl-tRNA synthetase, putative 0.0016 0.0043 0.025
Brugia malayi sulfakinin receptor protein 0.0041 0.0457 0.1031
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0294 0.0645
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.0457 0.1078
Echinococcus multilocularis methionine tRNA synthetase 0.0024 0.0174 0.0174
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.0457 0.0457
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.0457 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0642 0.9187
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0255 0.3521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0229
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0457 0.0457
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0097 0.0097
Onchocerca volvulus 0.0041 0.0457 0.4344
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0457 0.1497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0294 0.0694
Schistosoma mansoni hypothetical protein 0.0128 0.1911 0.6411
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0457 0.1497
Brugia malayi G protein-coupled receptor 0.0041 0.0457 0.1031
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0457 0.0457
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0294 0.0947
Echinococcus granulosus intermediate filament protein 0.0027 0.0236 0.0236
Brugia malayi Doublecortin family protein 0.0019 0.0097 0.0177
Schistosoma mansoni amine GPCR 0.0041 0.0457 0.1497
Brugia malayi RNA binding protein 0.0064 0.0852 0.1969
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0024 0.0174 0.0412
Brugia malayi ecdysteroid receptor 0.0031 0.0294 0.0645
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0294 0.2718
Schistosoma mansoni zinc finger protein 0.0022 0.0149 0.0455
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0113 0.066
Onchocerca volvulus 0.0019 0.0097 0.0747
Brugia malayi Dopamine receptor protein 2 0.0041 0.0457 0.1031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0294 0.0645
Schistosoma mansoni hypothetical protein 0.0041 0.0457 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0294 0.0645
Schistosoma mansoni loxhd1 0.0019 0.0097 0.0281
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0027 0.023 0.023
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.0457 0.1078
Schistosoma mansoni hypothetical protein 0.0023 0.0169 0.0523
Loa Loa (eye worm) hypothetical protein 0.0169 0.2595 0.6125
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0033 0.0334 0.2369
Schistosoma mansoni hypothetical protein 0.0055 0.0698 0.2312
Onchocerca volvulus 0.0031 0.0294 0.2718
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0642 0.9187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0642 0.9187
Brugia malayi nuclear receptor NHR-88 0.0031 0.0294 0.0645
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0642 0.9187
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0642 0.0642
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0642 0.9187
Toxoplasma gondii methionyl-tRNA synthetase 0.0038 0.0408 0.628
Schistosoma mansoni DNA helicase recq5 0.002 0.0113 0.0337
Schistosoma mansoni isoleucine--tRNA ligase 0.0027 0.023 0.0729
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.0457 0.0457
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.0457 0.0457
Echinococcus granulosus RUN 0.0019 0.0097 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0022 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0457 0.0457
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.0457 0.1078
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0792
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.002 0.0111 0.0835
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.0457 0.4344
Echinococcus granulosus glutaminyl tRNA synthetase 0.005 0.0616 0.0616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Echinococcus granulosus glycyl tRNA synthetase 0.005 0.0605 0.0605
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0036 0.0375 0.5275
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 0.0698 1
Echinococcus multilocularis allatostatin A receptor 0.0041 0.0457 0.0457
Brugia malayi hypothetical protein 0.0019 0.0097 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0185 0.1468
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0154 0.1034
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0457 0.0457
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.0457 0.1497
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0457 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0267 0.4236 1
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0027 0.023 0.023
Echinococcus multilocularis muscleblind protein 0.0169 0.2595 0.2595
Loa Loa (eye worm) hypothetical protein 0.0029 0.0255 0.0601
Loa Loa (eye worm) RecQ helicase 0.002 0.0113 0.0268
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0457 0.0457
Echinococcus granulosus neuropeptide receptor 0.0041 0.0457 0.0457
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0113 0.1456
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1911 0.1911
Onchocerca volvulus 0.0041 0.0457 0.4344
Echinococcus granulosus neuropeptide receptor 0.0041 0.0457 0.0457
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0457 0.1497
Onchocerca volvulus 0.0041 0.0457 0.4344
Brugia malayi TAR-binding protein 0.0064 0.0852 0.1969
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0022 0.0053
Echinococcus granulosus methionine tRNA synthetase 0.0024 0.0174 0.0174
Leishmania major glutaminyl-tRNA synthetase, putative 0.0016 0.0043 0.0426
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.0457 0.1497
Schistosoma mansoni nuclear receptor 0.0015 0.0022 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0159 0.2425 0.8149
Schistosoma mansoni opsin-like receptor 0.0041 0.0457 0.1497
Onchocerca volvulus 0.0041 0.0457 0.4344
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0294 0.0947
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.0457 0.1078
Onchocerca volvulus 0.0041 0.0457 0.4344
Echinococcus granulosus lamin 0.0027 0.0236 0.0236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0852 0.2011
Loa Loa (eye worm) hypothetical protein 0.0092 0.1319 0.3113
Brugia malayi glutaminyl-tRNA synthetase 0.007 0.0948 0.2196
Schistosoma mansoni hypothetical protein 0.0041 0.0457 0.1497
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0095 0.1364 0.1353
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Schistosoma mansoni methionine-tRNA synthetase 0.0154 0.2354 0.7908
Schistosoma mansoni hypothetical protein 0.0041 0.0457 0.1497
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0051 0.0122
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi hypothetical protein 0.0016 0.0051 0.0069
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0642 0.9187
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0294 0.0294
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0294 0.0947
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.0457 0.0457
Treponema pallidum isoleucyl-tRNA synthetase 0.0027 0.023 0.0325
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Leishmania major hypothetical protein, conserved 0.0029 0.0255 0.3521
Brugia malayi hypothetical protein 0.0019 0.0097 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Onchocerca volvulus 0.0041 0.0457 0.4344
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0457 0.0457
Entamoeba histolytica DNA repair and recombination protein, putative 0.0055 0.0698 0.276
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0027 0.023 0.0216
Schistosoma mansoni methionine-tRNA synthetase 0.0024 0.0174 0.0542
Chlamydia trachomatis isoleucine--tRNA ligase 0.0027 0.023 0.0922
Echinococcus granulosus zinc finger protein 0.0022 0.0149 0.0149
Entamoeba histolytica glutaminyl-tRNA synthetase, putative 0.0036 0.0375 0.1456
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0024 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0294 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0294 0.0645
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0154 0.2354 0.2354
Onchocerca volvulus 0.0041 0.0457 0.4344
Brugia malayi putative neuropeptide receptor 0.0041 0.0457 0.1031
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0057
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi steroid hormone receptor 0.0031 0.0294 0.0645
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0154 0.2042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.0457 0.1031
Brugia malayi hypothetical protein 0.0041 0.0457 0.1031
Brugia malayi hypothetical protein 0.0029 0.0255 0.0551
Onchocerca volvulus 0.0041 0.0457 0.4344
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0294 0.0294
Brugia malayi AKH receptor 0.0041 0.0457 0.1031
Onchocerca volvulus 0.0027 0.0236 0.2138
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0457 0.0457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0294 0.0694
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0255 0.1595
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.0457 0.1031
Schistosoma mansoni jun-related protein 0.0077 0.1066 0.3555
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0056 0.0717 0.1694
Loa Loa (eye worm) hypothetical protein 0.0149 0.2258 0.5331
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0457 0.0457
Brugia malayi Serotonin receptor 0.0041 0.0457 0.1031
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0205 0.0644
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Schistosoma mansoni neuropeptide receptor 0.0041 0.0457 0.1497
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.0457 0.0457
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0642 0.9187
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 0.0698 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0113 0.1456
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0055 0.0698 0.5858
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0294 0.0294
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0613 1 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.0852 0.2011
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0852 0.2833
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0294 0.0645
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0185 0.1468
Plasmodium vivax glutamine--tRNA ligase, putative 0.0016 0.0043 0.0911
Trypanosoma brucei protein kinase, putative 0.0052 0.0642 0.5382
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.0457 0.1497
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0055 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0014 0.0014 0.0014
Plasmodium falciparum methionine--tRNA ligase 0.0024 0.0174 0.1063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0294 0.0645
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Onchocerca volvulus 0.0041 0.0457 0.4344
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0027 0.023 0.6741
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Echinococcus multilocularis lamin 0.0027 0.0236 0.0236
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0255 0.2063
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0457 0.1497
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0021 0.0134 0.0134
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0334 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 0.0698 1
Echinococcus multilocularis glutaminyl tRNA synthetase 0.005 0.0616 0.0616
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0668 0.0668
Onchocerca volvulus 0.0055 0.0689 0.6662
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 0.0698 1
Giardia lamblia Ribonuclease H 0.0022 0.0154 0.2042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Echinococcus granulosus hypothetical protein 0.0041 0.0457 0.0457
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0027 0.023 0.3153
Schistosoma mansoni zinc finger protein 0.0017 0.0068 0.0183
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0113 0.0216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0055 0.0698 0.5858
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0097 0.0097
Onchocerca volvulus 0.0041 0.0457 0.4344
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0457 0.0457
Onchocerca volvulus 0.0041 0.0457 0.4344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0294 0.0645
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0294 0.0947
Schistosoma mansoni opsin-like receptor 0.0041 0.0457 0.1497
Echinococcus granulosus sex peptide receptor 0.0041 0.0457 0.0457
Schistosoma mansoni neuropeptide receptor 0.0041 0.0457 0.1497
Leishmania major asparaginyl-tRNA synthetase, putative 0.002 0.0111 0.1425
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Echinococcus granulosus neuropeptide s receptor 0.0041 0.0457 0.0457
Loa Loa (eye worm) glycyl-tRNA synthetase 0.005 0.0605 0.1428
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0294 0.0947
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0255 0.7527
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi methionyl-tRNA synthetase 0.0024 0.0174 0.0361
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Mycobacterium tuberculosis Possible DNA glycosylase 0.0095 0.1364 0.1353
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0294 0.0294
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0122
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0642 0.0642
Schistosoma mansoni polycystin 1-related 0.0019 0.0097 0.0281
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.0183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0503 0.1187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Trypanosoma cruzi ISWI complex protein 0.0017 0.0068 0.0792
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0022 0.0022
Echinococcus multilocularis muscleblind protein 1 0.0169 0.2595 0.2595
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0905 0.0905
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0101 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0236 0.0558
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Loa Loa (eye worm) glutaminyl-tRNA synthetase 0.007 0.0948 0.2237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0294 0.0294
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0236 0.0558
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.0457 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0294 0.0645
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0027 0.023 0.087
Brugia malayi intermediate filament protein 0.0027 0.0236 0.0507
Schistosoma mansoni phosphoglucomutase 0.0022 0.0154 0.0472
Brugia malayi RNase H family protein 0.0022 0.0154 0.0311
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0294 0.0294
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0095 0.1364 0.1353
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0169 0.0398
Loa Loa (eye worm) hypothetical protein 0.0046 0.0547 0.1292
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0022 0.0029
Schistosoma mansoni lipoxygenase 0.0053 0.0668 0.2212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Echinococcus granulosus tar DNA binding protein 0.0064 0.0852 0.0852
Giardia lamblia Rrm3p helicase 0.0055 0.0698 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0294 0.0645
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Plasmodium falciparum glutamine--tRNA ligase, putative 0.0016 0.0043 0.0193
Brugia malayi MH2 domain containing protein 0.0135 0.2029 0.4763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0101 0.0295
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0457 0.1497
Giardia lamblia Methionyl-tRNA synthetase 0.0024 0.0174 0.2347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0294 0.0947
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.0457 0.1031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0056 0.0717 0.1649
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0694
Brugia malayi G-protein coupled receptor 0.0041 0.0457 0.1031
Echinococcus granulosus somatostatin receptor 0.0041 0.0457 0.0457
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0642 0.9187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Brugia malayi glycyl-tRNA synthetase 0.005 0.0605 0.1382
Loa Loa (eye worm) hypothetical protein 0.0027 0.0228 0.0538
Echinococcus granulosus serotonin receptor 0.0041 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0192 0.2973 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.0457 0.0457
Brugia malayi neuropeptide F receptor 0.0041 0.0457 0.1031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0294 0.0694
Giardia lamblia Glutaminyl-tRNA synthetase 0.0036 0.0375 0.5275
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0457 0.0457
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0642 0.5382
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0095 0.1364 0.4779
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0294 0.0294
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0457 0.1078
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.0457 0.1078
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0457 0.0457
Giardia lamblia Leucyl-tRNA synthetase 0.0028 0.0238 0.3278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0122
Plasmodium vivax methionine--tRNA ligase, putative 0.0024 0.0174 0.5016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0294 0.0694
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0097 0.0097
Echinococcus multilocularis serotonin receptor 0.0041 0.0457 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Brugia malayi RNase H family protein 0.0022 0.0154 0.0311
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0457 0.0457
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.0457 0.0457
Leishmania major leucyl-tRNA synthetase, putative 0.0033 0.0334 0.4678
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0457 0.1497
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0154 0.1311
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.0457 0.1031
Schistosoma mansoni lipoxygenase 0.0019 0.0097 0.0281
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.0268
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0024 0.0174 0.1188
Brugia malayi ORL1-like opioid receptor 0.0041 0.0457 0.1031
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0852 0.0852
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.0457 0.1078
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0027 0.023 0.0222
Brugia malayi bZIP transcription factor family protein 0.0095 0.1362 0.318
Echinococcus multilocularis ribonuclease H1 0.0022 0.0154 0.0154
Brugia malayi hypothetical protein 0.0267 0.4236 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0457 0.1497
Trypanosoma brucei RNA helicase, putative 0.0084 0.1181 1
Onchocerca volvulus 0.0041 0.0457 0.4344
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0642 0.9187
Mycobacterium ulcerans thymidine phosphorylase 0.0613 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0457 0.1078
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0294 0.0947
Onchocerca volvulus 0.0041 0.0457 0.4344
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0053

Activities

Activity type Activity value Assay description Source Reference
Activation (functional) = 78 % In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP. ChEMBL. 10915043
Activation (functional) = 78 % In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP. ChEMBL. 10915043
EC50 (functional) = 34 nM In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP. ChEMBL. 10915043
EC50 (functional) = 34 nM In vitro efficacy at beta-3 adrenoceptors, quantified by measuring intracellular cAMP. ChEMBL. 10915043
IC50 (binding) = 1200 nM In vitro binding affinity at beta-2 adrenergic receptors in the presence of [125]iodocyanopindolol. ChEMBL. 10915043
IC50 (binding) = 1200 nM In vitro binding affinity at beta-2 adrenergic receptors in the presence of [125]iodocyanopindolol. ChEMBL. 10915043
IC50 (binding) = 6000 nM In vitro binding affinity at beta-1 adrenergic receptors in the presence of [125]iodocyanopindolol. ChEMBL. 10915043
IC50 (binding) = 6000 nM In vitro binding affinity at beta-1 adrenergic receptors in the presence of [125]iodocyanopindolol. ChEMBL. 10915043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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