Detailed information for compound 541685

Basic information

Technical information
  • TDR Targets ID: 541685
  • Name: [(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]- 3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dih ydrogen phosphate
  • MW: 437.344 | Formula: C17H20N5O7P
  • H donors: 5 H acceptors: 8 LogP: -1.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2NCc1ccccc1)COP(=O)(O)O
  • InChi: 1S/C17H20N5O7P/c23-13-11(7-28-30(25,26)27)29-17(14(13)24)22-9-21-12-15(19-8-20-16(12)22)18-6-10-4-2-1-3-5-10/h1-5,8-9,11,13-14,17,23-24H,6-7H2,(H,18,19,20)(H2,25,26,27)/t11-,13-,14-,17-/m1/s1
  • InChiKey: DWVANBHPEPSMOV-LSCFUAHRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2R,3S,4R,5R)-5-[6-(benzylamino)-9-purinyl]-3,4-dihydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(phenylmethylamino)purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • benzyl-AMP
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(phenylmethylamino)purin-9-yl]tetrahydrofuran-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(phenylmethylamino)-9-purinyl]-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • N(6)-Benzyladenosine-5'-monophosphate
  • NSC 255523
  • Benzyl-adenosine monophosphate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Starlite/ChEMBL References
Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of three chitinase genes similar to S. cerevisiae CTS1 (YLR286C) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1   163 aa 146 aa 22.6 %
Leishmania major hypothetical protein, conserved 2'-deoxynucleoside 5'-phosphate N-hydrolase 1   163 aa 161 aa 26.1 %
Leishmania mexicana hypothetical protein, conserved 2'-deoxynucleoside 5'-phosphate N-hydrolase 1   163 aa 169 aa 29.0 %
Leishmania infantum hypothetical protein, conserved 2'-deoxynucleoside 5'-phosphate N-hydrolase 1   163 aa 170 aa 27.6 %
Trypanosoma cruzi hypothetical protein, conserved 2'-deoxynucleoside 5'-phosphate N-hydrolase 1   163 aa 140 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0062 0.0651 0.1271
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0024 0.0028
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0046
Brugia malayi conserved hypotetical protein 0.001 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0158 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.2643 0.3326
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.071
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.016 0.0948
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0441 0.0754
Schistosoma mansoni smad1 5 8 and 0.0016 0.0101 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0043
Loa Loa (eye worm) serotonin transporter b 0.0224 0.2605 0.5099
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0023
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0024 0.0028
Brugia malayi MH2 domain containing protein 0.0016 0.0101 0.0193
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0158 0.0155
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0024 0.0043
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1179 0.1482
Brugia malayi MH2 domain containing protein 0.0016 0.0101 0.0193
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0659 0.0827
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.2643 0.2641
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0025 0.0039
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0038 0.0365 0.0363
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0222 0.1314
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.001 0.0024 0.0038
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0024 0.0043
Echinococcus multilocularis geminin 0.0165 0.1897 0.1895
Brugia malayi ecdysone receptor 0.001 0.0025 0.0045
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0057 0.0828
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0379 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.378 0.649
Schistosoma mansoni sodium-dependent amino acid transporter 0.0038 0.0365 0.0457
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0025 0.0023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0158 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0158 0.0304
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0018 0.0016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0379 0.0998
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0158 0.0195
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.0322 0.378 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0101 0.0098
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1179 0.3525
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0092 0.0113
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0379 0.225
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0024 0.0043
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.071
Brugia malayi Nuclear hormone receptor E75 0.001 0.0025 0.0045
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1179 0.6993
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0038 0.0365 0.0457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Echinococcus multilocularis smad 0.0016 0.0101 0.0098
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0024 0.0028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0025 0.0029
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0141 0.0272
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Echinococcus granulosus sodium and chloride dependent glycine 0.0038 0.0365 0.0457
Schistosoma mansoni lipoxygenase 0.0019 0.0141 0.0175
Mycobacterium ulcerans thioesterase 0.0021 0.0154 0.0912
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0651 0.0649
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0158 0.0304
Echinococcus granulosus microtubule associated protein 2 0.0667 0.7942 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0184 0.0355
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0307 0.0597
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0101 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0158 0.0155
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0141 0.0139
Schistosoma mansoni hypothetical protein 0.0019 0.0141 0.0175
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.016 0.24
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0158 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0251 0.4427
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0379 0.0998
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0222 0.1314
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0379 0.1129
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0141 0.0139
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1179 0.2306
Brugia malayi Doublecortin family protein 0.0019 0.0141 0.0272
Brugia malayi hypothetical protein 0.001 0.0025 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0018 0.002
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1179 0.3525
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0203 0.1205
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0251 0.0744
Loa Loa (eye worm) hypothetical protein 0.0041 0.0405 0.0788
Onchocerca volvulus 0.0043 0.0423 0.0722
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0025 0.0029
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0203 0.0394
Brugia malayi TAR-binding protein 0.0062 0.0651 0.1271
Loa Loa (eye worm) hypothetical protein 0.0224 0.2605 0.5099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0158 0.0195
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0038 0.0365 0.0457
Brugia malayi nuclear hormone receptor 0.0021 0.0158 0.0304
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.016 0.0948
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0203 0.1205
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0101 0.0124
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0145 0.0862
Mycobacterium ulcerans polyketide synthase 0.0025 0.0203 0.1205
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0379 0.1129
Onchocerca volvulus 0.001 0.0025 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0158 0.0195
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0072
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.016 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0158 0.0304
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0024 0.0028
Toxoplasma gondii hypothetical protein 0.0038 0.0365 0.5522
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0199 0.0386
Onchocerca volvulus 0.0038 0.0365 0.0623
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0154 0.0912
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.378 1
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0024 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0628 0.0788
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0043
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.1686 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0039 0.0071
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0024 0.0022
Echinococcus granulosus RUN 0.0019 0.0141 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Echinococcus granulosus Smad4 0.0016 0.0101 0.0124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Loa Loa (eye worm) hypothetical protein 0.0224 0.2605 0.5099
Schistosoma mansoni sodium/chloride dependent transporter 0.0038 0.0365 0.0457
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1179 0.6993
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.2643 0.3326
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0043
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.5522
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0038 0.0365 0.0457
Onchocerca volvulus 0.0224 0.2605 0.4471
Schistosoma mansoni smad1 5 8 and 0.0016 0.0101 0.0124
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0222 0.1314
Schistosoma mansoni smad1 5 8 and 0.0016 0.0101 0.0124
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0251 0.3782
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0024 0.0043
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.001 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0492 0.096
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1585 0.9397
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1179 0.1482
Schistosoma mansoni hypothetical protein 0.0165 0.1897 0.2386
Brugia malayi MH1 domain containing protein 0.0009 0.0014 0.0023
Schistosoma mansoni zinc finger protein 0.001 0.0025 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0158 0.0304
Loa Loa (eye worm) DR-78 0.001 0.0025 0.0045
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0158 0.0195
Echinococcus granulosus serotonin transporter 0.0224 0.2605 0.3278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0158 0.0304
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0039 0.0047
Toxoplasma gondii hypothetical protein 0.0038 0.0365 0.5522
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0101 0.0124
Brugia malayi Muscleblind-like protein 0.0148 0.1685 0.3296
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0203 0.1205
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0027 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1179 0.2022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.2605 0.5099
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0628 0.1657
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0024 0.0028
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0024 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0628 0.0788
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3341 1
Onchocerca volvulus 0.0021 0.0158 0.0267
Schistosoma mansoni loxhd1 0.0019 0.0141 0.0175
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3341 1
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.016 0.0948
Brugia malayi ecdysteroid receptor 0.0021 0.0158 0.0304
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0244 0.0474
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0025 0.0045
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0024 0.0028
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0024 0.0022
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.016 0.0948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0158 0.0195
Schistosoma mansoni lipoxygenase 0.0054 0.0563 0.0706
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0379 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0158 0.0304
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0118 0.1759
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0379 1
Trypanosoma cruzi hypothetical protein 0.0322 0.378 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1585 0.9397
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0203 0.1205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0492 0.096
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0024 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.5106 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0025 0.0039
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0379 0.0739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0158 0.0304
Mycobacterium ulcerans polyketide synthase 0.0026 0.0222 0.1314
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0018 0.002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0184 0.0355
Onchocerca volvulus 0.0019 0.0141 0.0239
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0203 0.1205
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1179 0.3115
Schistosoma mansoni nuclear hormone receptor 0.001 0.0025 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0158 0.0195
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0092 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0659 0.0827
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.0817
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0492 0.096
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0194 0.1151
Loa Loa (eye worm) norepinephrine transporter 0.0224 0.2605 0.5099
Brugia malayi nuclear receptor NHR-67 0.001 0.0025 0.0045
Loa Loa (eye worm) Smad1 0.0016 0.0101 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.0817
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.035 0.2074
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0024 0.0028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0158 0.0195
Brugia malayi 6-phosphofructokinase 0.0106 0.1179 0.2306
Brugia malayi Smad1 0.0016 0.0101 0.0193
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0158 0.0195
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0024 0.0028
Schistosoma mansoni nuclear receptor 0.001 0.0025 0.0029
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0075 0.0447
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0158 0.0195
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.5522
Echinococcus multilocularis sodium and chloride dependent glycine 0.0038 0.0365 0.0363
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0025 0.0045
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0251 0.4427
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0113
Echinococcus multilocularis cpg binding protein 0.003 0.0264 0.0261
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0113
Schistosoma mansoni hypothetical protein 0.0033 0.0307 0.0384
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0203 0.1205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.2643 0.2641
Echinococcus multilocularis sodium and chloride dependent glycine 0.0038 0.0365 0.0363
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0158 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0628 0.3726
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.016 0.0158
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0024 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0222 0.1314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0158 0.0155
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0038 0.0365 0.0457
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0039 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.065 0.0816
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1179 0.2306
Plasmodium vivax amine transporter, putative 0.0038 0.0365 0.5522
Trichomonas vaginalis set domain proteins, putative 0.0491 0.5823 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0158 0.0304
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0072
Echinococcus granulosus geminin 0.0165 0.1897 0.2386
Onchocerca volvulus 0.0491 0.5823 1
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3341 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0251 0.0744
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0101 0.0098
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0469 0.0913
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.5522
Echinococcus granulosus muscleblind protein 0.0148 0.1685 0.2119
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0251 0.3782
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.016 0.0309
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0039 0.0037
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0203 0.1205
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0628 0.0626
Brugia malayi hypothetical protein 0.0011 0.0039 0.0072
Brugia malayi hypothetical protein 0.0038 0.0365 0.071
Echinococcus multilocularis muscleblind protein 0.0148 0.1685 0.1683
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0272
Schistosoma mansoni nuclear receptor 0.001 0.0025 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0659 0.0827
Brugia malayi MH2 domain containing protein 0.0236 0.2752 0.5387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0092 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0141 0.0175
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0141 0.3682
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Brugia malayi Pre-SET motif family protein 0.0432 0.5106 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0158 0.0195
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0141 0.0175
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0025 0.0029
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0251 0.6586
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1179 0.6993
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0025 0.0029
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.016 0.0948
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0251 0.3782
Onchocerca volvulus 0.001 0.0024 0.0038
Treponema pallidum sodium- and chloride- dependent transporter 0.0224 0.2605 0.7795
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0024 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0158 0.0304
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.016 0.24
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0038 0.0365 0.0363
Plasmodium vivax SET domain protein, putative 0.0062 0.0659 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.016 0.0948
Echinococcus multilocularis Smad4 0.0016 0.0101 0.0098
Schistosoma mansoni cpg binding protein 0.0028 0.0244 0.0305
Plasmodium falciparum amino acid transporter, putative 0.0038 0.0365 0.9616
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0628 0.9532
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.2643 0.3326
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0072
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.035 0.2074
Echinococcus granulosus expressed protein 0.001 0.0024 0.0028
Brugia malayi nuclear receptor NHR-88 0.001 0.0025 0.0045
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0154 0.0912
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.035 0.2074
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0099 0.1474
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0158 0.0155
Entamoeba histolytica G protein alpha subunit, putative 0.001 0.0024 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0659 0.0827
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.1686 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0145 0.0862
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0072
Schistosoma mansoni sodium/chloride dependent transporter 0.0224 0.2605 0.3278
Schistosoma mansoni rab6-interacting 0.0019 0.0141 0.0175
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0158 0.0195
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.001 0.0024 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0158 0.0155
Echinococcus granulosus sodium and chloride dependent glycine 0.0038 0.0365 0.0457
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0222 0.1314
Onchocerca volvulus 0.0028 0.0244 0.0416
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0272
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0379 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0158 0.0304
Echinococcus granulosus cpg binding protein 0.003 0.0264 0.0329
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0038 0.0365 1
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0176
Schistosoma mansoni ap endonuclease 0.0039 0.0379 0.0475
Echinococcus multilocularis serotonin transporter 0.0224 0.2605 0.2603
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0024 0.0028
Schistosoma mansoni ap endonuclease 0.0039 0.0379 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.0817
Toxoplasma gondii exonuclease III APE 0.0039 0.0379 0.5742
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0158 0.0304
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0222 0.1314
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0563 0.0561
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.016 0.0158
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0024 0.0043
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.016 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.378 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3341 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0149 0.0885
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0009 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0024 0.0043
Echinococcus multilocularis RUN 0.0019 0.0141 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0379 0.1129
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0141 0.0175
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0024 0.0028
Onchocerca volvulus 0.001 0.0024 0.0038
Leishmania major hypothetical protein, conserved 0.0322 0.378 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.035 0.2074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0379 0.0475
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1179 0.2022
Schistosoma mansoni hypothetical protein 0.0165 0.1897 0.2386
Mycobacterium tuberculosis Probable exported protein 0.0008 0.0002 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0158 0.0304
Trypanosoma cruzi hypothetical protein 0.0322 0.378 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0251 0.3782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.2643 0.3326
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0224 0.2605 0.5099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0379 0.0998
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0024 0.0028
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1179 0.2306
Brugia malayi nuclear receptor RXR 0.0011 0.0039 0.0072
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0043 0.008
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0024 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.2643 0.5174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0025 0.0029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0659 0.0657
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0025 0.0045
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0145 0.0862
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0113
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0025 0.0045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0158 0.0195
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0659 1
Plasmodium falciparum ornithine aminotransferase 0.0021 0.016 0.4179
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0024 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.071
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Onchocerca volvulus 0.0062 0.0659 0.1128
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1179 0.3115
Echinococcus granulosus tar DNA binding protein 0.0062 0.0651 0.0817
Plasmodium falciparum transporter, putative 0.0038 0.0365 0.9616
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.7942 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0222 0.1314
Echinococcus granulosus smad 0.0016 0.0101 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0628 0.3726
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0628 0.3726
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0624 0.0783
Brugia malayi steroid hormone receptor 0.0021 0.0158 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0024 0.0043
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.016 0.0948
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1179 0.3525
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0103 0.061
Brugia malayi Nuclear hormone receptor E75 0.001 0.0025 0.0045
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0024 0.0028
Echinococcus multilocularis expressed protein 0.001 0.0024 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0158 0.0304
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.0817
Brugia malayi hypothetical protein 0.0019 0.0141 0.0272
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.016 0.0948
Brugia malayi Pre-SET motif family protein 0.0062 0.0659 0.1287
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0224 0.2605 0.3278
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.016 0.0198
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0038 0.0365 0.071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0158 0.0195
Schistosoma mansoni hypothetical protein 0.0015 0.0092 0.0113
Brugia malayi hypothetical protein 0.0011 0.0039 0.0072
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.1686 0.2893
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.7942 0.7942
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0659 0.0657
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0024 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0158 0.0195
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0307 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0158 0.0195
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0024 0.0028
Schistosoma mansoni sodium/chloride dependent transporter 0.0038 0.0365 0.0457
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.378 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Onchocerca volvulus 0.001 0.0025 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0158 0.0304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Brugia malayi 6-phosphofructokinase 0.0106 0.1179 0.2306
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0025 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0651 0.1271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0103 0.061
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Schistosoma mansoni coup transcription factor 0.0021 0.0158 0.0195
Echinococcus multilocularis GPCR, family 2 0.0015 0.0092 0.009
Echinococcus granulosus GPCR family 2 0.0015 0.0092 0.0113
Echinococcus granulosus ornithine aminotransferase 0.0021 0.016 0.0198
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0203 0.1205
Brugia malayi tailless protein 0.001 0.0025 0.0045
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.016 0.0948
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0492 0.096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.2643 0.5174
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0651 0.1271
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0039 0.0072
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0158 0.0304
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0628 0.0788
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0251 0.3782
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Echinococcus granulosus Aminotransferase class III 0.0021 0.016 0.0198
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0251 0.6586
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.012 0.071
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.016 0.0948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0158 0.0304
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0158 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0158 0.0304
Brugia malayi MH1 domain containing protein 0.0009 0.0014 0.0023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0379 0.225
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0628 0.3726
Schistosoma mansoni Smad4 0.0016 0.0101 0.0124
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0158 0.0304
Brugia malayi hypothetical protein 0.0019 0.0141 0.0272
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1585 0.9397
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0158 0.0267
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.0817
Loa Loa (eye worm) nuclear factor I 0.0009 0.0014 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Schistosoma mansoni rab6-interacting 0.0019 0.0141 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0158 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0158 0.0304
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0158 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0365 0.5522
Onchocerca volvulus 0.001 0.0024 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0158 0.0304
Loa Loa (eye worm) hypothetical protein 0.0148 0.1685 0.3296
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0103 0.061
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0563 0.0706
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0024 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0039 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0101 0.0193
Echinococcus multilocularis Aminotransferase class III 0.0021 0.016 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0158 0.0155
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0251 0.0427
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1179 0.2022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0158 0.0155
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.001 0.0024 0.0038
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1179 0.1482
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0158 0.0195
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0025 0.0029
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0024 0.0022
Mycobacterium ulcerans hypothetical protein 0.0148 0.1686 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0038 0.0365 0.0457
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0158 0.0195
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0024 0.0043
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0018 0.002
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0024 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.2752 0.5387
Loa Loa (eye worm) hypothetical protein 0.0062 0.0659 0.1287
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1179 0.3525
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0038 0.0365 0.071
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0651 0.1271
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1179 0.3115
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0158 0.0267
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0659 0.0827
Schistosoma mansoni cpg binding protein 0.003 0.0264 0.0329
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0045
Brugia malayi nuclear hormone receptor 0.001 0.0025 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.2752 0.5387
Onchocerca volvulus 0.0038 0.0365 0.0623
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0025 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.2643 0.3326
Schistosoma mansoni polycystin 1-related 0.0019 0.0141 0.0175
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0024 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1179 0.2022
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1685 0.1683
Brugia malayi MH1 domain containing protein 0.0016 0.0101 0.0193
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0379 0.0739
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0025 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0574 0.87
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0379 0.0998
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0038 0.0365 0.0457
Brugia malayi G-protein alpha subunit 0.001 0.0024 0.0043
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0038 0.0365 0.0363
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0379 0.0648
Brugia malayi RNA binding protein 0.0062 0.0651 0.1271
Onchocerca volvulus 0.0023 0.0184 0.0312
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0203 0.1205
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1179 0.1177
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0043
Brugia malayi phosphofructokinase 0.0106 0.1179 0.2306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0379 0.5742
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.016 0.0948
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0184 0.109
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0024 0.0022
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0154 0.0912
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0365 0.071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0092 0.0176
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0024 0.0038
Brugia malayi hypothetical protein 0.001 0.0024 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0158 0.0195
Schistosoma mansoni smad 0.0016 0.0101 0.0124
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0141 0.2114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0072
Onchocerca volvulus 0.0038 0.0365 0.0623
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0251 0.0427
Loa Loa (eye worm) solute carrier family 6 member 4 0.0224 0.2605 0.5099
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.1686 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0024 0.0028
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0251 0.0744
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0037 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0158 0.0304
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0222 0.334
Brugia malayi CXXC zinc finger family protein 0.0028 0.0244 0.0474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0304
Brugia malayi MH1 domain containing protein 0.0016 0.0101 0.0193
Schistosoma mansoni nuclear hormone receptor 0.001 0.0025 0.0029
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0024 0.0043
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0194 0.1151
Brugia malayi nuclear receptor NHR-88 0.0021 0.0158 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Brugia malayi nuclear receptor RXR 0.001 0.0025 0.0045
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0101 0.0193
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0025 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0158 0.0155
Brugia malayi hypothetical protein 0.001 0.0025 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0092 0.009
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0222 0.1314
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3341 0.5736
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0158 0.0304
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0148 0.1685 0.3296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0025 0.0023
Schistosoma mansoni cpg binding protein 0.003 0.0264 0.0329
Onchocerca volvulus 0.0019 0.0141 0.0239
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.1686 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0141 0.0139

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Activity at LPA3 receptor expressed in rat RH7777 cells assessed as potentiation of LPA-induced intracellular calcium concentration ChEMBL. 18467108
Activity (functional) Antagonist activity at LPA2 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration ChEMBL. 18467108
Activity (functional) Antagonist activity at LPA1 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration ChEMBL. 18467108
Activity (functional) Activity at LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of LPA-induced intracellular calcium concentration ChEMBL. 18467108
Activity (functional) Activity at LPA4 receptor expressed in CHO cells assessed as inhibition of LPA-induced intracellular calcium concentration ChEMBL. 18467108
Ki (binding) = 1.8 uM Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically ChEMBL. 25108359
Ki (binding) = 1.9 uM Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically ChEMBL. 25108359

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.