Detailed information for compound 574993

Basic information

Technical information
  • TDR Targets ID: 574993
  • Name: 2-methylpropan-2-amine; sulfuric acid
  • MW: 244.352 | Formula: C8H24N2O4S
  • H donors: 4 H acceptors: 4 LogP: -3.12 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OS(=O)(=O)O.CC(N)(C)C.CC(N)(C)C
  • InChi: 1S/2C4H11N.H2O4S/c2*1-4(2,3)5;1-5(2,3)4/h2*5H2,1-3H3;(H2,1,2,3,4)
  • InChiKey: JZHIWRJMRVFHOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-2-propanamine; sulfuric acid
  • tert-butylamine; sulfuric acid
  • 63302-54-5
  • 2-Propanamine, 2-methyl-, sulfate (2:1)
  • Bis(tert-butylammonium) sulphate
  • EINECS 264-083-7

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis zinc finger protein 0.002 0.0022 0.0022
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0091 0.0085
Toxoplasma gondii type I fatty acid synthase, putative 0.0075 0.0451 0.5608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0232 0.0249
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Loa Loa (eye worm) DR-78 0.0019 0.0016 0.0009
Onchocerca volvulus 0.0075 0.0455 0.2613
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0687 0.0699
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0306 0.2265 0.226
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0054 0.0288 0.0316
Schistosoma mansoni hypothetical protein 0.0083 0.0519 0.056
Loa Loa (eye worm) hypothetical protein 0.0087 0.0546 0.054
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0747 0.082
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0016 0.0015
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 0.0751 0.0811
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0183 0.0168
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0016 0.0015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0113 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0183 0.0177
Mycobacterium ulcerans polyketide synthase 0.0056 0.0301 0.0301
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0113 0.0612
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0152 0.0162
Plasmodium vivax SET domain protein, putative 0.0029 0.0097 0.0366
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0072 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0097 0.0366
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0072 0.003
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0056 0.0301 0.033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0183 0.0168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0183 0.0197
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0318 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0183 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0455 0.049
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0045 0.0216 0.0234
Loa Loa (eye worm) acyl carrier protein 0.0026 0.0066 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0318 0.0342
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0112 0.0747 0.0807
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0091 0.0097
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0112 0.0747 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0183 0.0168
Giardia lamblia PHD finger protein 15 0.0029 0.0091 0.0787
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0625 0.0685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1326 0.1433
Brugia malayi Cytochrome P450 family protein 0.0023 0.0044 0.0029
Echinococcus granulosus zinc finger protein 0.002 0.0022 0.0022
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0072 0.0518
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0046 0.0229 0.0248
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0781 0.0843
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0059 0.0328 0.036
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0112 0.0747 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0112 0.0747 0.0747
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0154 0.0147
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1197 0.9241 1
Entamoeba histolytica hypothetical protein 0.0035 0.014 0.1421
Loa Loa (eye worm) hypothetical protein 0.0112 0.0747 0.0741
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0183 0.0197
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0016 0.0015
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0301 0.0301
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0263 0.1928 0.1923
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0751 0.0736
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.1326 0.132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0183 0.0168
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0113 0.0612
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0016 0.0015
Brugia malayi hypothetical protein 0.0087 0.0546 0.0531
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0112 0.0747 0.0747
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0318 0.0311
Mycobacterium ulcerans lipase LipD 0.0075 0.0455 0.0455
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0183 0.0197
Schistosoma mansoni zinc finger protein 0.002 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0183 0.0197
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0118 0.0791 0.0868
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0019 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0183 0.0168
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Toxoplasma gondii propionate-CoA ligase 0.0112 0.0747 1
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0017 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.1326 0.1433
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0112 0.0747 0.9421
Mycobacterium leprae Probable polyketide synthase Pks1 0.0059 0.0328 0.0357
Leishmania major hypothetical protein, conserved 0.0075 0.0455 0.0452
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.6307 0.6825
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0781 0.0775
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0113 0.0612
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0455 0.0498
Echinococcus multilocularis muscleblind protein 1 0.0306 0.2265 0.245
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0232 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0183 0.0168
Onchocerca volvulus 0.0052 0.0272 0.1526
Onchocerca volvulus Alhambra homolog 0.0029 0.0091 0.0449
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0113 0.0612
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0112 0.0747 0.0747
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0452 0.0487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0747 0.082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0112 0.0747 0.082
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0234 0.0252
Loa Loa (eye worm) hypothetical protein 0.0109 0.0719 0.0713
Leishmania major 4-coumarate:coa ligase-like protein 0.0112 0.0747 0.0775
Schistosoma mansoni bromodomain containing protein 0.0064 0.0369 0.0397
Echinococcus multilocularis GPCR, family 2 0.0083 0.0519 0.056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.014 0.015
Leishmania major hypothetical protein, conserved 0.0105 0.0687 0.0708
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.003 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0183 0.0197
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0183 0.0197
Leishmania major pantothenate kinase subunit, putative 0.0027 0.008 0.0039
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0056 0.0301 0.033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.034 0.0367
Loa Loa (eye worm) beta-lactamase 0.0075 0.0455 0.0448
Mycobacterium ulcerans hypothetical protein 0.0075 0.0455 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0183 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0519 0.0504
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Schistosoma mansoni zinc finger protein 0.0019 0.0016 0.0015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0112 0.0747 0.0747
Brugia malayi Pre-SET motif family protein 0.0029 0.0097 0.0081
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0318 0.0348
Schistosoma mansoni nuclear hormone receptor 0.004 0.0183 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1326 0.1433
Mycobacterium ulcerans polyketide synthase 0.0059 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0154 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0027
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0016 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0183 0.0177
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0045 0.0216 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0112 0.0747 0.0775
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0152 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1761 0.1756
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0044 0.0038
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0033
Brugia malayi nuclear receptor RXR 0.0021 0.0034 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0032 0.0114 0.0125
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1761 0.1756
Schistosoma mansoni hypothetical protein 0.072 0.5505 0.5956
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0091 0.0286
Brugia malayi AMP-binding enzyme family protein 0.0112 0.0747 0.0733
Trichomonas vaginalis antibiotic synthetase, putative 0.0112 0.0747 0.4162
Brugia malayi Bromodomain containing protein 0.0039 0.017 0.0155
Brugia malayi beta-lactamase 0.0075 0.0455 0.0439
Onchocerca volvulus 0.004 0.0183 0.0998
Brugia malayi hypothetical protein 0.0068 0.0396 0.0381
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0016 0.0015
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0331 0.0325
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0455 0.0498
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0747 0.082
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0751 0.0811
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0751 0.0811
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0781 0.0781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.1326 0.1312
Brugia malayi AMP-binding enzyme family protein 0.0112 0.0747 0.0733
Entamoeba histolytica acyl-CoA synthetase, putative 0.0118 0.0791 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1473 0.1467
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0455 0.557
Schistosoma mansoni eyes absent homolog 0.0087 0.0546 0.059
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0118 0.0791 0.0868
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0042 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0318 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0183 0.0168
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0059 0.0328 0.0328
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0455 0.0498
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Brugia malayi ecdysteroid receptor 0.004 0.0183 0.0168
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.034 0.0367
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0183 0.0197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0112 0.0747 0.9421
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0091 0.0286
Mycobacterium tuberculosis Conserved protein 0.0075 0.0455 0.0498
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0088 0.0094
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.1856 0.2007
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0045 0.0047
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0112 0.0747 0.0817
Brugia malayi Muscleblind-like protein 0.0306 0.2265 0.2253
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0112 0.0747 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0455 0.2357
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0112 0.0747 0.082
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0183 0.0168
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0112 0.0747 0.0764
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0455 0.2357
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0183 0.0197
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0027 0.008 0.0039
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0036 0.0148 0.1132
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0687 0.8724
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0016 0.0015
Mycobacterium tuberculosis Conserved protein 0.0075 0.0455 0.0498
Schistosoma mansoni ap endonuclease 0.0058 0.0318 0.0342
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0209 0.2022
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1294 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.0031
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1294 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0455 0.0498
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0059 0.0328 0.0357
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0034 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1695 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0091 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Brugia malayi beta-lactamase family protein 0.0075 0.0455 0.0439
Toxoplasma gondii type I fatty acid synthase, putative 0.004 0.0176 0.1538
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0455 0.0446
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0318 0.0297
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0112 0.0747 0.0817
Schistosoma mansoni hypothetical protein 0.0029 0.0091 0.0097
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0072 0.0065
Leishmania major acetyl-CoA synthetase, putative 0.0112 0.0747 0.0775
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0183 0.0168
Loa Loa (eye worm) hypothetical protein 0.0112 0.0747 0.0741
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0687 0.9105
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0455 0.0448
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0034 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0318 0.3636
Entamoeba histolytica hypothetical protein 0.0035 0.014 0.1421
Brugia malayi Bromodomain containing protein 0.0076 0.0462 0.0447
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0183 0.0998
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0318 0.1513
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0112 0.0747 0.0807
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0455 0.2357
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0687 0.0699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0318 0.5
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0113 0.0612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Echinococcus multilocularis muscleblind protein 0.0306 0.2265 0.245
Brugia malayi AMP-binding enzyme family protein 0.0112 0.0747 0.0733
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0122 0.0107
Schistosoma mansoni nuclear receptor 0.0019 0.0016 0.0015
Mycobacterium tuberculosis Probable thioesterase TesA 0.0046 0.0229 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0016 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0183 0.0197
Loa Loa (eye worm) hypothetical protein 0.0254 0.1856 0.185
Onchocerca volvulus 0.0112 0.0747 0.4357
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0234 0.0252
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0781 0.0775
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0183 0.0197
Echinococcus granulosus long chain fatty acid transport protein 4 0.1197 0.9241 1
Schistosoma mansoni ap endonuclease 0.0058 0.0318 0.0342
Brugia malayi nuclear receptor NHR-88 0.004 0.0183 0.0168
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0118 0.0791 0.0791
Schistosoma mansoni flap endonuclease-1 0.0024 0.0052 0.0055
Mycobacterium tuberculosis Conserved protein 0.0075 0.0455 0.0498
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0455 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0183 0.0168
Loa Loa (eye worm) hypothetical protein 0.018 0.1276 0.127
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0183 0.0197
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0113 0.5
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0455 0.5665
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0183 0.0197
Mycobacterium ulcerans thioesterase TesA 0.0046 0.0229 0.0229
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0056 0.0301 0.0327
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0183 0.0197
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0016 0.0015
Leishmania major fatty acid transporter protein-like protein 0.1181 0.9119 1
Mycobacterium ulcerans thioesterase 0.0046 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0112 0.0747 0.0741
Brugia malayi jmjC domain containing protein 0.0094 0.0603 0.0588
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0455 0.049
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0687 0.9105
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.004 0.0179 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0183 0.0197
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0118 0.0791 0.0777
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0112 0.0747 0.0764
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0045 0.0222 0.0243
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0112 0.0747 0.0817
Toxoplasma gondii exonuclease III APE 0.0058 0.0318 0.3636
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1197 0.9241 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0781 0.4368
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.1856 0.2007
Schistosoma mansoni hypothetical protein 0.0035 0.014 0.015
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0781 0.9862
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0183 0.0197
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0113 0.0255
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0118 0.0791 0.0791
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0318 0.3636
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0164 0.1154 0.1148
Loa Loa (eye worm) hypothetical protein 0.0087 0.0546 0.054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0455 0.0498
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0112 0.0747 0.0817
Echinococcus multilocularis peregrin 0.0031 0.011 0.0117
Brugia malayi PHD-finger family protein 0.0029 0.0091 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0183 0.0168
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0045 0.0047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0183 0.0197
Brugia malayi nuclear hormone receptor 0.004 0.0183 0.0168
Trichomonas vaginalis esterase, putative 0.0075 0.0455 0.2357
Loa Loa (eye worm) hypothetical protein 0.0112 0.0747 0.0741
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0112 0.0747 0.9545
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0519 0.0512
Echinococcus granulosus jumonji domain containing protein 0.004 0.0179 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0263 0.1928 0.1916
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0083 0.0516 0.0566
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0097 0.0103
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0455 0.0498
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0183 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0183 0.0197
Brugia malayi MH2 domain containing protein 0.0242 0.1761 0.1748
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0455 0.049
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0781 0.0843
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.014 0.015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0097 0.0103
Loa Loa (eye worm) fatty acid synthase 0.0055 0.0295 0.0289
Onchocerca volvulus 0.0209 0.1504 0.8866
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0016 0.0015
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0059 0.0328 0.0357
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0112 0.0747 0.082
Echinococcus granulosus AMP dependent ligase 0.0021 0.0033 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.014 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0113 0.1684
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0118 0.0791 0.0791
Onchocerca volvulus Fatty acid synthase homolog 0.01 0.065 0.3779
Schistosoma mansoni survival motor neuron protein 0.0052 0.0272 0.0293
Brugia malayi Flap endonuclease-1 0.0026 0.0072 0.0056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0232 0.0249
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0781 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0016 0.0009
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1197 0.9241 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0016 0.0009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0272 0.0257
Toxoplasma gondii ABC1 family protein 0.0075 0.0455 0.5665
Mycobacterium ulcerans acetyl-CoA synthetase 0.0112 0.0747 0.0747
Brugia malayi jmjC domain containing protein 0.0037 0.0154 0.0138
Schistosoma mansoni hypothetical protein 0.0052 0.0272 0.0293
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Loa Loa (eye worm) hypothetical protein 0.0306 0.2265 0.226
Entamoeba histolytica acyl-coA synthetase, putative 0.0112 0.0747 0.9421
Loa Loa (eye worm) hypothetical protein 0.0105 0.0687 0.0681
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0059 0.0328 0.036
Brugia malayi Pre-SET motif family protein 0.0205 0.1473 0.1459
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0455 0.049
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0112 0.0747 1
Echinococcus granulosus geminin 0.072 0.5505 0.5956
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0113 0.0612
Schistosoma mansoni hypothetical protein 0.0083 0.0519 0.056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0263 0.1928 0.1916
Leishmania major acetyl-CoA synthetase, putative 0.0112 0.0747 0.0775
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0183 0.0197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0519 0.056
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0183 0.0197
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0016 0.0015
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0781 1
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.1276 0.1262
Loa Loa (eye worm) hypothetical protein 0.0263 0.1928 0.1923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0183 0.0177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0183 0.0197
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0183 0.0998
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0455 0.0455
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0112 0.0747 0.0764
Echinococcus granulosus FTZ F1 alpha 0.004 0.0183 0.0197
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0056 0.0301 0.0286
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0183 0.0177
Brugia malayi steroid hormone receptor 0.004 0.0183 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0687 0.9105
Schistosoma mansoni nuclear receptor 0.0019 0.0016 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0183 0.0197
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0139 0.0148
Echinococcus granulosus flap endonuclease 1 0.0026 0.0072 0.0076
Mycobacterium ulcerans polyketide synthase Pks9 0.0037 0.0154 0.0154
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0112 0.0747 0.0747
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0781 0.4368
Echinococcus multilocularis geminin 0.072 0.5505 0.5956
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0183 0.0168
Mycobacterium ulcerans hypothetical protein 0.0112 0.0747 0.0747
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0318 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0091 0.0286
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0603 0.0651
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0519 0.056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0027
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0044 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1326 0.1433
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Schistosoma mansoni hypothetical protein 0.0047 0.0234 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0112 0.0747 0.0733
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0056 0.0301 0.0327
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0179 0.0192
Schistosoma mansoni hypothetical protein 0.0083 0.0519 0.056
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0037 0.0154 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0781 0.4368
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0183 0.0197
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0519 0.056
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0091 0.0097
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0059 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0301 0.0301
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0045 0.0216 0.0216
Brugia malayi hypothetical protein 0.0021 0.0034 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0183 0.0168
Schistosoma mansoni FFA transport protein 0.1197 0.9241 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0112 0.0747 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0183 0.0177
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0034 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0455 0.0446
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0252 0.0246
Schistosoma mansoni coup transcription factor 0.004 0.0183 0.0197
Onchocerca volvulus 0.0029 0.0097 0.0482
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0118 0.0791 0.0868
Onchocerca volvulus 0.0164 0.1154 0.6777
Brugia malayi Cytochrome P450 family protein 0.0023 0.0044 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0318 0.0342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0044 0.0038
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.0692 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1326 0.1433
Schistosoma mansoni acetyl-CoA synthetase 0.0112 0.0747 0.0807
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0183 0.0197
Loa Loa (eye worm) hypothetical protein 0.0083 0.0519 0.0512
Echinococcus granulosus peregrin 0.0031 0.011 0.0117
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0112 0.0747 0.0733
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0072 0.0076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0205 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0183 0.0168
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0781 0.0856
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0059 0.0328 0.036
Mycobacterium ulcerans polyketide synthase Pks13 0.0083 0.0516 0.0516
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0781 0.0801
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0083 0.0516 0.0566
Brugia malayi AMP-binding enzyme family protein 0.0164 0.1154 0.114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.1326 0.1433
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0455 0.0439
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0027
Mycobacterium ulcerans Type I modular polyketide synthase 0.0056 0.0301 0.0301
Brugia malayi hypothetical protein 0.0254 0.1856 0.1843
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0687 0.9105
Brugia malayi Bromodomain containing protein 0.0031 0.011 0.0094
Onchocerca volvulus 0.0075 0.0455 0.2613
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0183 0.0168
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0016 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0112 0.0747 0.0733
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0318 0.3709
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0154 0.0165
Brugia malayi 6-phosphofructokinase 0.0117 0.0781 0.0766
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0455 0.0498
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0183 0.0998
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.0751 0.0779
Schistosoma mansoni thyroid hormone receptor 0.004 0.0183 0.0197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0027
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0016 0.0009
Onchocerca volvulus 0.0126 0.0851 0.4973
Entamoeba histolytica hypothetical protein 0.0035 0.014 0.1421
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0781 0.0812
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0519 0.056
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0054 0.0288 0.0316
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0091 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0154 0.0165
Mycobacterium leprae Polyketide synthase Pks13 0.0083 0.0516 0.0563
Leishmania major 4-coumarate:coa ligase-like protein 0.0112 0.0747 0.0775
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0045 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Onchocerca volvulus 0.0112 0.0747 0.4357
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0097 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0183 0.0197
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0318 0.3059
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0165
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0318 0.3755
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0112 0.0747 0.0764
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0112 0.0747 0.9545
Brugia malayi hypothetical protein 0.0105 0.0687 0.0672
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0085
Schistosoma mansoni thyroid hormone receptor 0.004 0.0183 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0781 0.4368
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0781 0.0843
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Brugia malayi hypothetical protein 0.0021 0.0034 0.0018
Brugia malayi hypothetical protein 0.0035 0.014 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1181 0.9119 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0318 0.0297
Onchocerca volvulus 0.0233 0.1695 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0112 0.0747 0.4162
Echinococcus granulosus GPCR family 2 0.0083 0.0519 0.056
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0072 0.0376
Entamoeba histolytica hypothetical protein 0.0035 0.014 0.1421
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.1326 0.1433
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0747 0.082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0072 0.0428 0.0422
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0118 0.0791 0.0865
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0781 0.0843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0112 0.0747 0.082
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.0018
Schistosoma mansoni hypothetical protein 0.0083 0.0519 0.056
Loa Loa (eye worm) hypothetical protein 0.0112 0.0747 0.0741
Mycobacterium ulcerans acyl-CoA synthetase 0.0118 0.0791 0.0791
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0183 0.0177
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.3625 0.3975
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0455 0.2357
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0318 0.0301
Loa Loa (eye worm) hypothetical protein 0.0047 0.0232 0.0226
Mycobacterium leprae Probable lipase LipE 0.0075 0.0455 0.0495
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0781 0.9862
Brugia malayi phosphofructokinase 0.0117 0.0781 0.0766
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0044 0.0044
Loa Loa (eye worm) oxidoreductase 0.0112 0.0747 0.0741
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0113 0.0255
Schistosoma mansoni hypothetical protein 0.018 0.1276 0.1379
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0034 0.0035
Brugia malayi 6-phosphofructokinase 0.0117 0.0781 0.0766
Mycobacterium ulcerans beta-lactamase 0.0075 0.0455 0.0455
Schistosoma mansoni hypothetical protein 0.072 0.5505 0.5956
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0781 0.9862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0183 0.0177
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0751 0.0824
Brugia malayi beta-lactamase family protein 0.0075 0.0455 0.0439
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0113 0.0612
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0113 0.1064
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0112 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0103
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0164 0.1154 0.1265
Mycobacterium ulcerans fatty acid synthase Fas 0.0017 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0232 0.0249
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0603 0.0651
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0037 0.0154 0.0166
Onchocerca volvulus 0.0075 0.0455 0.2613
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0519 0.0504
Schistosoma mansoni amine GPCR 0.0334 0.2485 0.2687
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0056 0.0301 0.033
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0112 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0016 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0781 0.0775
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0781 0.0853
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0318 0.1513
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0751 0.0751
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0056 0.0301 0.0301
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0455 0.2357
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0183 0.0197
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0021 0.0033 0.0033
Brugia malayi PHD-finger family protein 0.0025 0.0064 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0009
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1181 0.9119 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0118 0.0791 0.0868
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0016 0.0015
Echinococcus granulosus muscleblind protein 0.0306 0.2265 0.245
Echinococcus multilocularis AMP dependent ligase 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0075 0.0455 0.0448
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0455 0.0455
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0034 0.0027
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0105 0.0691 0.0676
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0112 0.0747 0.0747
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0118 0.0791 0.0791

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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