Detailed information for compound 58259

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 702.797 | Formula: C37H46N6O8
  • H donors: 3 H acceptors: 7 LogP: 4.78 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1)nc(cc2O[C@@H]1C[C@@H]2N(C1)C(=O)[C@H](CCCCC/C=C\[C@H]1[C@](NC2=O)(C1)C(=O)O)NC(=O)OC(C)(C)C)n1cnc(c1)C
  • InChi: 1S/C37H46N6O8/c1-22-19-42(21-38-22)31-17-30(26-14-13-24(49-5)15-28(26)39-31)50-25-16-29-32(44)41-37(34(46)47)18-23(37)11-9-7-6-8-10-12-27(33(45)43(29)20-25)40-35(48)51-36(2,3)4/h9,11,13-15,17,19,21,23,25,27,29H,6-8,10,12,16,18,20H2,1-5H3,(H,40,48)(H,41,44)(H,46,47)/b11-9-/t23-,25-,27+,29+,37-/m1/s1
  • InChiKey: MGRYRDPHJWDTIT-MCQSFFMYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7218
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0029 0.0029
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0024 0.0138
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0127 0.1065
Leishmania major phosphatidylinositol kinase related protein, putative 0.0171 0.0186 0.0504
Entamoeba histolytica protein kinase rad3, putative 0.0398 0.0458 0.3984
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0818
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.5823
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0166 0.1092
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.003 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.083 0.7275
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Onchocerca volvulus 0.0057 0.0049 0.0808
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0166 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0683 0.0799 0.7001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0683 0.0799 0.7001
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0011 0.0071
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1443 0.1711 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0087 0.0244
Echinococcus multilocularis bloom syndrome protein 0.0024 0.001 0.0009
Loa Loa (eye worm) gastrulation defective protein 1 0.0147 0.0156 0.1026
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0087 0.0918
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0154 0.0165 0.578
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0254 0.0286 0.1875
Onchocerca volvulus 0.0056 0.0047 0.0756
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.1829
Loa Loa (eye worm) Csnk2b protein 0.0041 0.003 0.0196
Leishmania major phosphatidylinositol 3-kinase, putative 0.0254 0.0286 0.0777
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0127 0.1065
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0196 0.0216 0.2396
Entamoeba histolytica hypothetical protein 0.0155 0.0166 0.1413
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0912 0.1074 0.1074
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0111 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0414 0.0477 0.4158
Brugia malayi hypothetical protein 0.0534 0.0621 0.5451
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0411 0.0474 0.4156
Onchocerca volvulus 0.0155 0.0166 0.3764
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.002 0.0699
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.002 0.0504
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0739 0.0867 0.2497
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0254 0.0286 0.2465
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0166 0.1092
Loa Loa (eye worm) hypothetical protein 0.0382 0.0439 0.2882
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0024 0.0024
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.011 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0444 0.0513 0.4476
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0739 0.0867 0.2497
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0087 0.071
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0166 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0322 0.2789
Brugia malayi hypothetical protein 0.0022 0.0006 0.0054
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0024 0.1445
Entamoeba histolytica hypothetical protein 0.081 0.0951 0.8341
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0138
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.02
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0049 0.1546
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0361 0.0414 0.0413
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0254 0.0286 0.2465
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0127 0.1065
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0414 0.0477 0.1372
Loa Loa (eye worm) phosphatidylinositol 3 0.0256 0.0288 0.1889
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0024 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.088 0.7711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.0507 0.442
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0739 0.0867 0.507
Loa Loa (eye worm) phosphatidylinositol 3 0.0695 0.0814 0.5345
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.088 0.7711
Schistosoma mansoni hypothetical protein 0.0285 0.0322 0.1884
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0089 0.0087 0.0507
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0201 0.0222 0.1943
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Entamoeba histolytica hypothetical protein 0.0155 0.0166 0.1413
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0411 0.0474 0.1361
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0166 0.5823
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0155
Echinococcus granulosus expressed protein 0.042 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0703 0.0823 0.5405
Leishmania major casein kinase II, putative 0.0154 0.0165 0.0447
Schistosoma mansoni protein kinase 0.0154 0.0165 0.0965
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0695 0.0814 0.2224
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0127 0.1065
Brugia malayi Protein kinase domain containing protein 0.015 0.0161 0.1411
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Leishmania major hypothetical protein, unknown function 0.0155 0.0166 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0729 0.0855 0.7493
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.003 0.032
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.005 0.0041 0.0357
Brugia malayi SH2 domain containing protein 0.0382 0.0439 0.3851
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0361 0.0414 0.2716
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7219
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0966 0.1139 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.044 0.0508 0.5986
Onchocerca volvulus 0.004 0.0029 0.0299
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0049 0.0378
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0006 0.0037
Brugia malayi M-phase phosphoprotein, mpp8 0.0115 0.0118 0.1037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0087 0.0244
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0216 0.0239 0.1569
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0037
Echinococcus multilocularis expressed conserved protein 0.0092 0.0091 0.009
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0166 0.0972
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0006 0.0037
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0074 0.0069 0.3183
Echinococcus granulosus cyclin dependent kinase 19 0.015 0.0161 0.0161
Onchocerca volvulus 0.0047 0.0037 0.049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0017 0.0113
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0057
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.02
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.0127 0.7237
Brugia malayi hypoxia-induced factor 1 0.0169 0.0184 0.1609
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0024 0.1445
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0049 0.0378
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.0127 1
Schistosoma mansoni kinase 0.0111 0.0114 0.0664
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0049 0.0339
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.002 0.0238
Toxoplasma gondii CMGC kinase, CK2 family 0.0154 0.0165 0.1946
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.0286 0.1669
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0966 0.1139 1
Toxoplasma gondii hypothetical protein 0.0036 0.0024 0.0284
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.003 0.0208
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Brugia malayi 6-phosphofructokinase 0.0122 0.0127 0.1114
Echinococcus multilocularis high voltage activated calcium channel beta 0.0098 0.0098 0.0097
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0166 0.1459
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0966 0.1139 0.3282
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0024 0.0024
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0166 0.1829
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0006 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0024 0.0156
Brugia malayi intracellular kinase 0.0057 0.0049 0.0431
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.075 0.088 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0166 0.0972
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0166 0.1961
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0113
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0216 0.0239 0.0239
Brugia malayi intermediate filament protein 0.0031 0.0017 0.015
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.0127 0.0127
Trypanosoma cruzi target of rapamycin kinase 3 0.0729 0.0855 0.2462
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.002 0.0238
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0739 0.0867 0.0867
Echinococcus multilocularis tumor protein p63 0.038 0.0436 0.0436
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0726 0.0851 0.7456
Plasmodium falciparum casein kinase II beta chain 0.0041 0.003 0.0854
Toxoplasma gondii ck2 beta subunit 0.0041 0.003 0.0353
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0103 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0508 0.4429
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0695 0.0814 0.9243
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0024 0.0138
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0006 0.0006
Echinococcus granulosus single minded 2 0.004 0.0029 0.0029
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0049 0.0287
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0127 0.1379
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0166 0.0166
Brugia malayi Pre-SET motif family protein 0.0034 0.0021 0.0184
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0166 0.1092
Echinococcus granulosus geminin 0.0192 0.0211 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0132 0.111
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.8356 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.0041 0.0304
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0143 0.1256
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0006 0.0006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0411 0.0474 0.4124
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0046 0.0269
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.002 0.0121
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0811 0.0953 0.8359
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0006 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0029 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0739 0.0867 0.7612
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0256 0.0288 0.0824
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Plasmodium vivax unspecified product 0.0154 0.0165 0.578
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0049 0.0378
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0166 0.1413
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0166 0.1459
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0006 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.075 0.088 0.2534
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0272 0.2343
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0254 0.0286 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0414 0.0477 0.539
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.002 0.5
Echinococcus granulosus intermediate filament protein 0.0031 0.0017 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.001 0.0028
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0126 0.0132 0.111
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.005 0.0041 0.0041
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0171 0.0186 0.0531
Brugia malayi hypothetical protein 0.0115 0.0119 0.1039
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0166 0.1701
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0006 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0024
Brugia malayi bHLH-PAS transcription factor 0.004 0.0029 0.0254
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.045
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0411 0.0474 0.4124
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.075 0.088 0.088
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0049 0.0378
Toxoplasma gondii GAF domain-containing protein 0.0036 0.0024 0.0284
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0361 0.0414 0.2716
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1443 0.1711 0.171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0043 0.032
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0286 0.3365
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0398 0.0458 0.0458
Trypanosoma cruzi casein kinase II, putative 0.0154 0.0165 0.0471
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.007 0.0562
Loa Loa (eye worm) hypothetical protein 0.0285 0.0322 0.2116
Onchocerca volvulus 0.0115 0.0118 0.2551
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.003 0.0208
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0043
Brugia malayi Csnk2b protein 0.0041 0.003 0.0261
Brugia malayi follicle stimulating hormone receptor 0.0266 0.0299 0.2625
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0166 0.0166
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0183 0.0201 0.1317
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0136 0.0143 0.0941
Loa Loa (eye worm) phosphatidylinositol 3 0.1286 0.1523 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0398 0.0458 0.0458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0029 0.0029
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0166 0.045
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0049 0.0049
Echinococcus granulosus protein kinase shaggy 0.0057 0.0049 0.0049
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0006 0.0054
Brugia malayi Protein kinase domain containing protein 0.002 0.0005 0.0038
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0703 0.0823 0.0823
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0006 0.0006
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0049 0.0129
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0087 0.0244
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0166 0.1413
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0017 0.015
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0006 0.0054
Brugia malayi hypothetical protein 0.004 0.0029 0.0253
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0777
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.5823
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Plasmodium falciparum casein kinase II beta chain 0.0041 0.003 0.0854
Loa Loa (eye worm) hypothetical protein 0.0115 0.0118 0.0777
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0166 0.0166
Brugia malayi Casein kinase II, alpha chain 0.0154 0.0165 0.1448
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0006 0.0006
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.003 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Schistosoma mansoni single-minded 0.0055 0.0046 0.0269
Echinococcus multilocularis expressed protein 0.042 0.0484 0.0484
Brugia malayi PXA domain containing protein 0.0023 0.0008 0.0071
Giardia lamblia GTOR 0.075 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0534 0.0621 0.4079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0011 0.0071
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0127 0.0834
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.0474
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0216 0.0239 0.0239
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0132 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0729 0.0855 0.7493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0729 0.0855 0.7493
Echinococcus multilocularis Zinc finger, PHD finger 0.0254 0.0286 0.0286
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Entamoeba histolytica hypothetical protein 0.0155 0.0166 0.1413
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.011 0.0918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0021 0.0123
Echinococcus multilocularis lamin 0.0031 0.0017 0.0017
Mycobacterium ulcerans putative regulatory protein 0.004 0.0029 0.1861
Plasmodium falciparum GAF domain-related protein, putative 0.0036 0.0024 0.0644
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.002 0.0121
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0538 0.4695
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.075 0.088 0.7711
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0024 0.0207
Brugia malayi Cytochrome P450 family protein 0.0033 0.0021 0.0179
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0029 0.0029
Onchocerca volvulus 0.0109 0.0111 0.237
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.015 0.0161 0.1056
Onchocerca volvulus Serine\/threonine kinase homolog 0.0216 0.0239 0.5594
Loa Loa (eye worm) calcium channel 0.0036 0.0024 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0166 0.1092
Entamoeba histolytica hypothetical protein 0.0414 0.0477 0.4158
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Toxoplasma gondii FATC domain-containing protein 0.0414 0.0477 0.5624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0966 0.1139 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0057
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0166 0.1413
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0166 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0683 0.0799 0.7001
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0017 0.0113
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0726 0.0851 0.7456
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.0127 0.0361
Loa Loa (eye worm) RecQ helicase 0.0024 0.001 0.0062
Leishmania major hypothetical protein, conserved 0.0038 0.0026 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0239 0.1397
Onchocerca volvulus 0.0155 0.0166 0.3764
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.003 0.003
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.008 0.008
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0037
Leishmania major cytochrome p450-like protein 0.0022 0.0007 0.0012
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0461 0.0533 0.6027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0021 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.005 0.0041 0.0304
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0166 0.1961
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0166 0.1092
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Loa Loa (eye worm) hypothetical protein 0.0398 0.0458 0.3005
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0414 0.0477 0.279
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.02
Loa Loa (eye worm) phosphatidylinositol 3 0.075 0.088 0.5779
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0729 0.0855 0.2337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.0507 0.442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0729 0.0855 0.7493
Echinococcus multilocularis geminin 0.0192 0.0211 0.0211
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0024 0.0024
Echinococcus granulosus serine protein kinase ATM 0.0414 0.0477 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0161 0.094
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0259 0.0292 0.0835
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0465 0.0538 0.3144
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.0299 0.1965
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0006 0.0037
Trypanosoma brucei protein kinase, putative 0.0057 0.0049 0.0488
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0007 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0361 0.0414 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1443 0.1711 0.171
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.002 0.0504
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0049 0.0323
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.005 0.0041 0.0041
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0006 0.0054
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.0127 0.0342
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0049 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0487 0.0564 0.4922
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0098 0.0098 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0021 0.0123
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0102 0.0103 0.0103
Loa Loa (eye worm) phosphofructokinase 0.0122 0.0127 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0739 0.0867 0.0867
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7219
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Trypanosoma brucei Casein kinase II 0.0154 0.0165 0.1815
Plasmodium vivax SET domain protein, putative 0.0034 0.0021 0.0735
Schistosoma mansoni hypothetical protein 0.0192 0.0211 0.1234
Plasmodium falciparum casein kinase 2, alpha subunit 0.0154 0.0165 0.5691
Loa Loa (eye worm) hypothetical protein 0.044 0.0508 0.3337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0026 0.0068
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.003 0.0266
Loa Loa (eye worm) hypothetical protein 0.0056 0.0047 0.031
Toxoplasma gondii hypothetical protein 0.0075 0.007 0.0825
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0047 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0043
Echinococcus granulosus tumor protein p63 0.038 0.0436 0.0436
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0087 0.0918
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0705 0.0826 0.7251
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0024 0.0024
Brugia malayi FAT domain containing protein 0.0285 0.0322 0.2828
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0254 0.0286 0.2506
Brugia malayi hypothetical protein 0.0022 0.0006 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0269 0.0303 0.2617
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0154 0.0165 0.1084
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0006 0.0041
Leishmania major hypothetical protein, conserved 0.3062 0.3653 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0154 0.0165 0.0165
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.007 0.0562
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0166 0.1459
Echinococcus multilocularis cyclin dependent kinase 19 0.015 0.0161 0.0161
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0115 0.0119 0.0778
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.0127 0.0834
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0254 0.0286 1
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0054 0.0045 0.0294
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0166 0.0474
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0143 0.0837
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.003 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0132 0.111
Brugia malayi hypothetical protein 0.0183 0.0201 0.1759
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.003 0.0076
Echinococcus multilocularis serine protein kinase ATM 0.0414 0.0477 0.0477
Brugia malayi PAS domain containing protein 0.0055 0.0046 0.0403
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.008 0.008
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0021 0.0135
Brugia malayi 6-phosphofructokinase 0.0122 0.0127 0.1114
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0285 0.0322 0.0322
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0008 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0683 0.0799 0.7001
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0239 0.2053
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.003 0.032
Brugia malayi Pre-SET motif family protein 0.0236 0.0264 0.2314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0439 0.0507 0.442
Entamoeba histolytica casein kinase, putative 0.0154 0.0165 0.1402
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0108
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0024 0.0024
Echinococcus granulosus lamin dm0 0.0031 0.0017 0.0017
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0127 0.1065
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0006 0.0054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0966 0.1139 1
Echinococcus granulosus casein kinase ii subunit alpha 0.0154 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0259 0.0292 0.1914
Schistosoma mansoni fkbp-rapamycin associated protein 0.0398 0.0458 0.2675
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0411 0.0474 0.5347
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0103 0.0601
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0254 0.0286 0.2465
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0201 0.0222 0.1454
Schistosoma mansoni hypothetical protein 0.0092 0.0091 0.0529
Schistosoma mansoni hypothetical protein 0.0059 0.0051 0.0297
Schistosoma mansoni hypothetical protein 0.0109 0.0111 0.065
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0049 0.0323
Schistosoma mansoni lamin 0.0031 0.0017 0.01
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0052 0.0043 0.0326
Echinococcus multilocularis survival motor neuron protein 1 0.0534 0.0621 0.0621
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0155 0.0166 0.1092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.081 0.0951 0.8341
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0087 0.071
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0026 0.022
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.3194
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0495 0.0574 0.5009
Echinococcus granulosus lamin 0.0031 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0361 0.0414 0.2417
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0024 0.0024
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0286 0.3365
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0966 0.1139 0.3282
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.0127 0.1065
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0127 0.0742
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0052 0.0043 0.0326
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0097 0.0097
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0254 0.0286 0.0286
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.003 0.008
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.075 0.088 0.2405
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0166 0.5736
Schistosoma mansoni lamin 0.0031 0.0017 0.01
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0006 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0166 1
Entamoeba histolytica protein kinase, putative 0.0057 0.0049 0.0378
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0074 0.0069 0.5207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0398 0.0458 0.4016
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0398 0.0458 0.1315
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Echinococcus granulosus high voltage activated calcium channel beta 0.0098 0.0098 0.0097
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0176 0.0191 0.1631
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0024 0.0024
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0011 0.0094
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.075 0.088 0.7724
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0026 0.0126
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0006 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0312 0.0354 0.3887
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0472 0.4111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.0849 0.7437
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0021 0.025
Echinococcus granulosus survival motor neuron protein 1 0.0534 0.0621 0.0621
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0569 0.0663 0.7477
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0166 0.5736
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0361 0.0414 0.0413
Trypanosoma cruzi polo-like protein kinase, putative 0.0216 0.0239 0.0684
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.002 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0166 0.1961
Brugia malayi serine/threonine-protein kinase plk-2 0.0216 0.0239 0.2096
Giardia lamblia Kinase, CMGC CK2 0.0154 0.0165 0.1687
Echinococcus multilocularis lamin dm0 0.0031 0.0017 0.0017
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0004 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.075 0.088 0.2405
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0024 0.0024
Echinococcus granulosus expressed conserved protein 0.0092 0.0091 0.009
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0285 0.0322 0.0322
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0006 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0052 0.0043 0.0119
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0729 0.0855 0.7493
Brugia malayi Protein kinase domain containing protein 0.0361 0.0414 0.3629
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.0286 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.0458 0.3984
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0102 0.0103 0.0103
Echinococcus multilocularis musashi 0.0031 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0254 0.0286 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0695 0.0814 0.7128
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0729 0.0855 0.9717
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0683 0.0799 0.9078
Entamoeba histolytica serine/threonine protein kinase, putative 0.0216 0.0239 0.2053
Giardia lamblia Hypothetical protein 0.0155 0.0166 0.1701
Toxoplasma gondii hypothetical protein 0.0036 0.0024 0.0284
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.003 0.008
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0024 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.083 0.7275
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.0286 0.2465
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.088 0.7711
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.001 0.0082
Entamoeba histolytica protein kinase domain containing protein 0.0154 0.0165 0.1402
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0166 0.5823
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.003 0.1042
Toxoplasma gondii target of rapamycin (TOR), putative 0.0724 0.0849 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0087 0.0087
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0049 0.0581
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.2907 0.3467 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.0097 0.0097
Onchocerca volvulus 0.0115 0.0118 0.2551
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0006 0.0037
Brugia malayi PXA domain containing protein 0.0023 0.0008 0.0071
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0049 0.0136
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0462 0.0535 0.4665
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0087 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0411 0.0474 0.4124
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Plasmodium vivax hypothetical protein 0.0155 0.0166 0.5823
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0006 0.0006
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0006 0.0006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.002 0.0238
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.0127 0.1065
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0063
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0286 0.0818
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Schistosoma mansoni intermediate filament proteins 0.0031 0.0017 0.01
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.005 0.0041 0.0304
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.041 0.0472 0.4111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0166 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.001 0.0009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0411 0.0474 0.4124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0166 0.1413
Leishmania major phosphatidylinositol 3-kinase, putative 0.0683 0.0799 0.2184
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0361 0.0414 0.3629
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0041
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.0127 1
Schistosoma mansoni survival motor neuron protein 0.0109 0.0111 0.065
Brugia malayi Serotonin receptor 0.0524 0.0609 0.5348
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.0127 0.0127
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.075 0.088 0.2534
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0006 0.0006
Trypanosoma brucei polo-like protein kinase 0.0216 0.0239 0.266
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.02
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0254 0.0286 0.0286
Brugia malayi phosphofructokinase 0.0122 0.0127 0.1114
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0043 0.032
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0703 0.0823 0.0823
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0414 0.0477 0.419
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0024 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0264 0.1732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0021 0.0123
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0477 0.0552 0.4844
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0165 0.1402
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.0127 0.7237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7219
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.002 0.0699
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0966 0.1139 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0006 0.0006
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.001 0.0028
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.003 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0037 0.0214
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.0184 0.1205
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.075 0.088 0.7711
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.075 0.088 0.5144
Trypanosoma cruzi polo-like protein kinase, putative 0.0216 0.0239 0.0684
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.002 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0243 0.0272 0.2343
Giardia lamblia Kinase, PLK 0.0216 0.0239 0.2545
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0166 0.1413
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.075 0.088 0.088
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.075 0.088 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.0286 0.2465
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0006 0.0006
Giardia lamblia Casein kinase II beta chain 0.0041 0.003 0.0114
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0087 0.071
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0315 0.0358 0.235
Onchocerca volvulus 0.0269 0.0303 0.721
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.003 0.0208
Schistosoma mansoni hypothetical protein 0.0192 0.0211 0.1234
Schistosoma mansoni hypothetical protein 0.0155 0.0166 0.0972
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.0127 0.0742
Echinococcus multilocularis 0.0155 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.004 0.0029 0.0169
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0216 0.0239 0.0649
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.0824 0.7218
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0006 0.0006
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0049 0.172
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0166 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.007 0.0562

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 39 nM Inhibition of hepatitis C virus in a cell based HCV replicon assay. ChEMBL. 15027850
IC50 (binding) = 14 nM Inhibitory concentration against hepatitis C virus NS3 protease ChEMBL. 15027850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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