Detailed information for compound 598310

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.537 | Formula: C23H30N8O
  • H donors: 6 H acceptors: 1 LogP: 0.66 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1ccc(cc1)CCNC1=NCCN1)Nc1ccc(cc1)CCNC1=NCCN1
  • InChi: 1S/C23H30N8O/c32-23(30-19-5-1-17(2-6-19)9-11-24-21-26-13-14-27-21)31-20-7-3-18(4-8-20)10-12-25-22-28-15-16-29-22/h1-8H,9-16H2,(H2,24,26,27)(H2,25,28,29)(H2,30,31,32)
  • InChiKey: UAVRJTDEFCSNRK-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Leishmania major GTP-binding protein, putative 0.0021 0.0066 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0066 0.0058
Giardia lamblia Sugar-proton symporter 0.0033 0.0195 0.1453
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0118
Schistosoma mansoni hypothetical protein 0.0065 0.0514 0.0635
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0334 0.1005
Schistosoma mansoni glucose transport protein 0.0237 0.2246 0.2825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Plasmodium falciparum calcium-dependent protein kinase 1 0.0074 0.0601 0.059
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0066 0.0054
Treponema pallidum prolyl-tRNA synthetase 0.0025 0.0112 0.0412
Echinococcus multilocularis lysyl tRNA synthetase 0.0053 0.0392 0.0408
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0021 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0263 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0046 0.0037
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0071 0.0189
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2825
Plasmodium falciparum calcium-dependent protein kinase 5 0.0074 0.0601 0.059
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0286 0.0347
Brugia malayi major facilitator superfamily protein 0.0033 0.0195 0.0231
Brugia malayi Pre-SET motif family protein 0.0852 0.8429 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0074 0.0601 0.059
Onchocerca volvulus 0.0019 0.0055 0.0047
Echinococcus multilocularis General substrate transporter 0.0204 0.1911 0.2037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0066 0.0068
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.1137 0.1207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Echinococcus granulosus synaptic vesicle 2 protein 0.0033 0.0195 0.0232
Echinococcus granulosus caspase 8 0.0146 0.1328 0.1664
Toxoplasma gondii protein kinase, putative 0.0672 0.6613 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0127
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0159 0.1453 0.1823
Onchocerca volvulus 0.0019 0.0055 0.0047
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0074 0.0601 0.0893
Plasmodium vivax SET domain protein, putative 0.0122 0.1089 0.1078
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0061 0.0475 0.1224
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0071 0.0575 0.1975
Onchocerca volvulus 0.0033 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0071 0.0575 0.0672
Onchocerca volvulus 0.0033 0.0195 0.0193
Giardia lamblia Prolyl-tRNA synthetase 0.0071 0.0575 0.5171
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.1089 0.1631
Loa Loa (eye worm) hypothetical protein 0.0074 0.0601 0.0702
Onchocerca volvulus 0.0033 0.0195 0.0193
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0438 0.1327
Echinococcus multilocularis calcium dependent protein kinase 0.0068 0.0545 0.0572
Leishmania major metacaspase, putative 0.0146 0.1328 0.4088
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0053 0.0392 0.0398
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0071 0.0063
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0045
Echinococcus multilocularis caspase 8 0.0146 0.1328 0.1412
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0597 0.9936
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0195 0.0193
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0623 0.0772
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.4778 0.5663
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0051 0.0028
Toxoplasma gondii thioredoxin reductase 0.0055 0.0412 0.0606
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0051 0.0059
Brugia malayi Muscleblind-like protein 0.016 0.1472 0.1746
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0224 0.0228
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.2855 0.3379
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0071 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis glucosylceramidase, putative 0.0371 0.3592 0.373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0002
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0597 0.0628
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0071 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trypanosoma cruzi ISWI complex protein 0.0033 0.0187 0.0549
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Plasmodium falciparum importin beta, putative 0.0028 0.014 0.0128
Trypanosoma cruzi hexose transporter, putative 0.0074 0.06 0.1829
Trypanosoma brucei glucosidase, putative 0.004 0.0263 0.0786
Trypanosoma brucei glucose transporter 2A 0.0074 0.06 0.1829
Chlamydia trachomatis lysine--tRNA ligase 0.0053 0.0392 0.2139
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0087 0.008
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2397
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0071 0.0075
Trypanosoma cruzi ISWI complex protein 0.0033 0.0187 0.0549
Echinococcus multilocularis caspase 3 0.0152 0.1388 0.1476
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0045
Echinococcus multilocularis solute carrier family 22 0.0033 0.0195 0.0197
Plasmodium falciparum proline--tRNA ligase 0.0083 0.0694 0.0683
Trichomonas vaginalis ran, putative 0.0021 0.0066 0.0058
Echinococcus granulosus GPCR family 2 0.0065 0.0514 0.0635
Plasmodium vivax hexose transporter 0.0237 0.2246 0.2237
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0224 0.0269
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0942 0.9332 1
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Brugia malayi MAP kinase sur-1 0.012 0.107 0.1269
Onchocerca volvulus 0.0033 0.0195 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0049
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0071 0.0189
Entamoeba histolytica hypothetical protein 0.0029 0.015 0.2364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0191
Schistosoma mansoni hypothetical protein 0.0237 0.2246 0.2825
Plasmodium vivax vivapain-2 0.0019 0.0055 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Onchocerca volvulus 0.0033 0.0195 0.0193
Brugia malayi MH2 domain containing protein 0.0116 0.1021 0.1211
Onchocerca volvulus 0.0033 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0141 0.1274 0.1502
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0195 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0632
Trypanosoma cruzi hexose transporter, putative 0.0074 0.06 0.1829
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Echinococcus granulosus lysyl tRNA synthetase 0.0053 0.0392 0.0481
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0116
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.012 0.107 0.3287
Trichomonas vaginalis CMGC family protein kinase 0.012 0.107 0.1103
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0597 0.0708
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0116
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0045 0.0312 0.1669
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.014 0.0194
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0053 0.0392 0.1186
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0071 0.0075
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0051 0.0127
Plasmodium falciparum glutathione reductase 0.0019 0.0051 0.0039
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0597 0.1821
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.1004 0.1254
Brugia malayi hypothetical protein 0.0033 0.0195 0.0231
Brugia malayi RNA, U transporter 1 0.0079 0.0657 0.078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0353 0.0366
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0114 0.1004 0.1254
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0074 0.0601 0.0713
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0038
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0353 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0159 0.1453 0.1823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0055 0.0764
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0046 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Leishmania major hypothetical protein, conserved 0.0033 0.0195 0.0574
Brugia malayi jmjC domain containing protein 0.0061 0.0472 0.0559
Trypanosoma cruzi metacaspase 5, putative 0.0146 0.1328 0.4088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0263 0.027
Plasmodium vivax CDK-related protein kinase 6, putative 0.1009 1 1
Schistosoma mansoni protein kinase 0.0074 0.0601 0.0745
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0117 0.1031 0.5387
Loa Loa (eye worm) glutathione reductase 0.0055 0.0412 0.0477
Echinococcus granulosus neuropeptide receptor A26 0.0543 0.5318 0.6709
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.1089 0.1155
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Schistosoma mansoni hypothetical protein 0.0518 0.5066 0.6391
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0154 0.0215
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0045 0.0312 0.1669
Trichomonas vaginalis CMGC family protein kinase 0.012 0.107 0.1103
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1328 0.1994
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0046 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni zinc finger protein 0.0033 0.0187 0.0221
Plasmodium falciparum hexose transporter 0.0237 0.2246 0.2237
Trypanosoma cruzi glucose transporter, putative 0.0033 0.0195 0.0574
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.054 0.1644
Trypanosoma cruzi metacaspase, putative 0.0146 0.1328 0.4088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0046 0.0113
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1119 0.605
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1119 0.6746
Plasmodium vivax metacaspase 1, putative 0.0146 0.1328 0.1318
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Schistosoma mansoni glucose transporter 0.0033 0.0195 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0055 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Entamoeba histolytica hypothetical protein 0.0053 0.0392 0.6469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0472 0.0581
Plasmodium falciparum metacaspase 1 0.0146 0.1328 0.1318
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0071 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0632
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0117 0.1031 0.619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0071 0.019
Giardia lamblia Kinase, CMGC MAPK 0.012 0.107 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0029 0.0153 0.017
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0071 0.0575 0.0713
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0033 0.0195 0.0934
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1328 0.1318
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.126 0.763
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.015 0.0177
Trypanosoma brucei glucose transporter 1E 0.0074 0.06 0.1829
Brugia malayi Thioredoxin reductase 0.0055 0.0412 0.0488
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0045
Leishmania major trypanothione reductase 0.0055 0.0412 0.1247
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0053 0.0392 0.1186
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0033 0.0195 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0154 0.0142
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.012 0.107 0.3287
Echinococcus granulosus General substrate transporter 0.0204 0.1911 0.2401
Trypanosoma brucei metacaspase 5, putative 0.0146 0.1328 0.4088
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0074 0.06 0.0614
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0055 0.0055
Echinococcus granulosus apoptotic protease activating factor 1 0.0211 0.198 0.2488
Onchocerca volvulus 0.0033 0.0195 0.0193
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0051 0.0127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0514 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus granulosus caspase 0.0298 0.2856 0.3596
Leishmania major hypothetical protein, conserved 0.0015 0.0012 0.0006
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.168 0.1983
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0083 0.0694 0.1034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0514 0.061
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0061 0.0475 0.0464
Echinococcus multilocularis neuropeptide s receptor 0.0543 0.5318 0.5693
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Schistosoma mansoni lozenge 0.0062 0.048 0.0592
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0053 0.0052
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0074 0.0601 0.059
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0146 0.1328 0.1575
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0431 0.053
Brugia malayi hypothetical protein 0.0033 0.0195 0.0231
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.012 0.107 0.3287
Mycobacterium ulcerans hypothetical protein 0.0177 0.1637 0.9939
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2397
Echinococcus multilocularis neuropeptide receptor A26 0.0543 0.5318 0.5693
Trichomonas vaginalis sugar transport protein, putative 0.0033 0.0195 0.0193
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0071 0.0189
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0051 0.0127
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0124 0.1103 0.6605
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0051 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0353 0.0432
Trypanosoma brucei trypanothione reductase 0.0055 0.0412 0.1247
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0074 0.06 0.1829
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0605 0.1845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Loa Loa (eye worm) hypothetical protein 0.0357 0.3448 0.4083
Schistosoma mansoni caspase-3 (C14 family) 0.0298 0.2856 0.3596
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Echinococcus granulosus microtubule associated protein 2 0.0802 0.7921 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0326 0.033
Trypanosoma cruzi hexose transporter 0.0074 0.06 0.1829
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0263 0.0264
Schistosoma mansoni sugar transporter 0.0033 0.0195 0.0232
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0628 0.0779
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.126 0.763
Plasmodium falciparum lysine--tRNA ligase 0.0053 0.0392 0.0381
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0342 0.0417
Trichomonas vaginalis myo-inositol transporter, putative 0.0033 0.0195 0.0193
Plasmodium falciparum mitogen-activated protein kinase 2 0.0385 0.3727 0.3719
Loa Loa (eye worm) hypothetical protein 0.0071 0.0575 0.0672
Schistosoma mansoni serine/threonine protein kinase 0.012 0.107 0.1338
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0054
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0074 0.0601 0.0745
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0472 0.0581
Onchocerca volvulus 0.0105 0.0912 0.094
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0605 0.1845
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Schistosoma mansoni ran 0.0021 0.0066 0.0068
Echinococcus granulosus neuropeptide s receptor 0.0543 0.5318 0.6709
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0071 0.0575 0.9571
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0472 0.0581
Trypanosoma brucei ISWI complex protein 0.0033 0.0187 0.0549
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0033 0.0195 0.0929
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0514 0.0635
Loa Loa (eye worm) hypothetical protein 0.0206 0.1929 0.228
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0412 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0002
Leishmania major cathepsin L-like protease 0.0019 0.0055 0.014
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Echinococcus multilocularis mitogen activated protein kinase 3 0.012 0.107 0.1135
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0263 0.0264
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.126 0.7103
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.2246 0.2329
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.168 0.2109
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 0.1637
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0055 0.0054
Onchocerca volvulus 0.0033 0.0195 0.0193
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0033 0.0195 0.0183
Leishmania major hypothetical protein, conserved 0.0029 0.0154 0.0447
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0045
Echinococcus multilocularis solute carrier family 22 0.0033 0.0195 0.0197
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0051 0.0039
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Brugia malayi hypothetical protein 0.0019 0.0049 0.0059
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0694 0.2122
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0431 0.053
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0051 0.0039
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Giardia lamblia Hexose transporter 0.0033 0.0195 0.1453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0178 0.1647 0.2477
Echinococcus multilocularis solute carrier family 22 0.0033 0.0195 0.0197
Loa Loa (eye worm) hypothetical protein 0.016 0.1472 0.1736
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0071 0.1029
Brugia malayi Sugar transporter family protein 0.0033 0.0195 0.0231
Echinococcus multilocularis GPCR, family 2 0.0065 0.0514 0.0539
Plasmodium falciparum calcium-dependent protein kinase 3 0.0074 0.0601 0.059
Echinococcus granulosus calcium dependent protein kinase 0.0068 0.0545 0.0674
Loa Loa (eye worm) ctsf protein 0.0019 0.0055 0.0054
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0109 0.0307
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Trichomonas vaginalis glucose transporter, putative 0.0074 0.06 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Brugia malayi Cell death protein 3 precursor 0.0357 0.3448 0.409
Giardia lamblia DINP protein human, muc B family 0.0019 0.0047 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0195 0.0193
Schistosoma mansoni bromodomain containing protein 0.0135 0.1213 0.1519
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Leishmania major cathepsin L-like protease 0.0074 0.0605 0.1845
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.3234 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Onchocerca volvulus 0.0122 0.1089 0.1123
Schistosoma mansoni hypothetical protein 0.0044 0.0301 0.0366
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0071 0.1029
Schistosoma mansoni alpha-glucosidase 0.0156 0.1426 0.1789
Trypanosoma brucei metacaspase 0.0146 0.1328 0.4088
Loa Loa (eye worm) hypothetical protein 0.0087 0.0731 0.0856
Echinococcus granulosus histone lysine methyltransferase setb 0.0159 0.1453 0.1823
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0263 0.0301
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0083 0.0694 0.2122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0071 0.0075
Echinococcus granulosus solute carrier family 22 0.0033 0.0195 0.0232
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0154 0.0447
Schistosoma mansoni sugar transporter 0.0033 0.0195 0.0232
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0051 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0334 0.1005
Brugia malayi jmjC domain containing protein 0.0057 0.0431 0.0511
Schistosoma mansoni protein kinase 0.0074 0.0601 0.0745
Echinococcus granulosus mitogen activated protein kinase 3 0.012 0.107 0.1338
Schistosoma mansoni protein kinase 0.0074 0.0601 0.0745
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0263 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Onchocerca volvulus 0.0033 0.0195 0.0193
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.0623 0.0638
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.012 0.107 0.1259
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0071 0.0575 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0628 0.0661
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Plasmodium falciparum calcium-dependent protein kinase 2 0.0074 0.0601 0.059
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0053 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0056
Schistosoma mansoni caspase-7 (C14 family) 0.0298 0.2856 0.3596
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0124 0.1103 0.138
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Echinococcus multilocularis muscleblind protein 1 0.016 0.1472 0.1566
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0124 0.1103 0.6646
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0263 0.0786
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0071 0.0189
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Echinococcus multilocularis Protein lozenge 0.0062 0.048 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Brugia malayi PHD-finger family protein 0.0053 0.0392 0.0465
Echinococcus granulosus peptidase Clp S14 family 0.0117 0.1031 0.1289
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0071 0.0084
Onchocerca volvulus 0.0211 0.198 0.2051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0195 0.022
Echinococcus multilocularis solute carrier family 22 0.0033 0.0195 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0051 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Plasmodium vivax calcium-dependent protein kinase, putative 0.0074 0.0601 0.059
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0178 0.1647 0.1637
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0412 0.1247
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.1137 0.1422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0353 0.0432
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0055 0.0764
Trichomonas vaginalis CMGC family protein kinase 0.012 0.107 0.1103
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Echinococcus granulosus solute carrier family 22 0.0033 0.0195 0.0232
Schistosoma mansoni sugar transporter 0.0033 0.0195 0.0232
Loa Loa (eye worm) hypothetical protein 0.0065 0.0514 0.0599
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0224 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0002
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0055 0.0047
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0412 0.0506
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0263 0.0264
Leishmania major lysyl-tRNA synthetase, putative 0.0053 0.0392 0.1186
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0033 0.0195 0.0929
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0071 0.0189
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0431 0.0449
Trypanosoma cruzi hexose transporter, putative 0.0074 0.06 0.1829
Onchocerca volvulus 0.0019 0.0055 0.0047
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0038
Schistosoma mansoni caspase-7 (C14 family) 0.0357 0.3448 0.4345
Schistosoma mansoni alpha-glucosidase 0.0156 0.1426 0.1789
Echinococcus multilocularis cysteine protease 0.0019 0.0055 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0475 0.2679
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Leishmania major cathepsin L-like protease 0.0074 0.0605 0.1845
Schistosoma mansoni lysyl-tRNA synthetase 0.0053 0.0392 0.0481
Loa Loa (eye worm) cysteine protease 0.0019 0.0055 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1456 0.4487
Brugia malayi Bromodomain containing protein 0.016 0.1464 0.1737
Toxoplasma gondii hypothetical protein 0.0054 0.0404 0.0594
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.168 0.179
Trypanosoma cruzi sugar transporter, putative 0.0033 0.0195 0.0574
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0445 0.135
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0012 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0514 0.0599
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0178 0.1647 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0051 0.0028
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0195 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Schistosoma mansoni ap endonuclease 0.0019 0.0046 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Brugia malayi Cam kinase protein 1 0.0074 0.0601 0.0713
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0224 0.0269
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0078
Schistosoma mansoni sugar transporter 0.0033 0.0195 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0195 0.0193
Trypanosoma brucei THT1 - hexose transporter, putative 0.0074 0.06 0.1829
Leishmania major importin beta-1 subunit, putative 0.0023 0.0087 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0745
Trypanosoma cruzi metacaspase, putative 0.0146 0.1328 0.4088
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Brugia malayi Sugar transporter family protein 0.0033 0.0195 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0263 0.0264
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0154 0.0142
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0046 0.0038
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0071 0.0189
Loa Loa (eye worm) hypothetical protein 0.0053 0.0392 0.0454
Echinococcus multilocularis caspase 2 0.0357 0.3448 0.3687
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0071 0.0189
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.1004 0.1254
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0053 0.0392 0.2161
Entamoeba histolytica cysteine protease, putative 0.0019 0.0055 0.0764
Mycobacterium tuberculosis Probable reductase 0.0125 0.1119 0.6746
Onchocerca volvulus 0.097 0.9613 1
Echinococcus multilocularis cysteine protease 0.0019 0.0055 0.0046
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0055 0.0046
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0087 0.0239
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2397
Loa Loa (eye worm) hypothetical protein 0.0492 0.4809 0.5699
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.0155
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0051 0.0127
Leishmania major cathepsin L-like protease 0.0019 0.0055 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0054
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0195 0.0193
Leishmania major glucose transporter/membrane transporter D2, putative 0.0074 0.06 0.1829
Trypanosoma cruzi metacaspase, putative 0.0146 0.1328 0.4088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Echinococcus granulosus geminin 0.0518 0.5066 0.6391
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0051 0.0028
Onchocerca volvulus 0.0019 0.0055 0.0047
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.126 0.763
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0334 0.1005
Plasmodium vivax sugar transporter, putative 0.0033 0.0195 0.0183
Trypanosoma cruzi metacaspase, putative 0.0146 0.1328 0.4088
Leishmania major hypothetical protein, conserved 0.0033 0.0187 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0033 0.0195 0.0197
Onchocerca volvulus 0.0019 0.0055 0.0047
Echinococcus granulosus muscleblind protein 0.016 0.1472 0.1846
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0412 0.0477
Trypanosoma cruzi metacaspase 5, putative 0.0146 0.1328 0.4088
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0065 0.0514 0.0635
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.012 0.107 0.3287
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0046 0.0035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0051 0.0028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.012 0.107 0.3287
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0051 0.0043
Mycobacterium ulcerans sugar transporter 0.0033 0.0195 0.0929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0055 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1929 0.2289
Toxoplasma gondii sugar transporter ST3 0.0033 0.0195 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Schistosoma mansoni hypothetical protein 0.0065 0.0514 0.0635
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0055 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0074 0.0601 0.059
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0071 0.0575 0.0713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.1456 0.4487
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0051 0.006
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0074 0.0601 0.0702
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0385 0.3727 0.3719
Schistosoma mansoni alpha glucosidase 0.004 0.0263 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.06 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0159 0.1453 0.1547
Toxoplasma gondii cathepsin CPL 0.0019 0.0055 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0537 0.5258 0.6238
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0042
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0033 0.0195 0.0232
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus multilocularis mitogen activated protein kinase 0.012 0.107 0.1135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0334 0.1005
Schistosoma mansoni hypothetical protein 0.0033 0.0187 0.0221
Trypanosoma cruzi hexose transporter, putative 0.004 0.0264 0.0788
Echinococcus granulosus solute carrier family 22 0.0033 0.0195 0.0232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0074 0.0601 0.1833
Schistosoma mansoni hypothetical protein 0.0211 0.198 0.2488
Echinococcus granulosus caspase 2 0.0357 0.3448 0.4345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1929 0.2289
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Schistosoma mansoni glucose transport protein 0.0237 0.2246 0.2825
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0046 0.0113
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0195 0.0231
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0298 0.2856 0.3596
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0475 0.0464
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.1004 0.1254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0514 0.0539
Trypanosoma brucei metacaspase MCA3 0.0146 0.1328 0.4088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0044
Leishmania major cathepsin L-like protease 0.0019 0.0055 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.06 0.0614
Leishmania major glucose transporter, lmgt3 0.0074 0.06 0.1829
Onchocerca volvulus 0.0033 0.0195 0.0193
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0055 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0066 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0124 0.1103 0.3392
Echinococcus granulosus cathepsin l1 0.0019 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Toxoplasma gondii hypothetical protein 0.0061 0.0475 0.0702
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0597 0.1821
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0055 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0002
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0074 0.0601 0.0893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0353 0.0366
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0597 0.074
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0852 0.8429 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0071 0.0089
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.012 0.107 0.3287
Echinococcus multilocularis importin subunit beta 1 0.0028 0.014 0.0138
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0071 0.0063
Brugia malayi Pre-SET motif family protein 0.0122 0.1089 0.1291
Loa Loa (eye worm) hypothetical protein 0.0076 0.0623 0.0728
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0025 0.0112 0.0412
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0071 0.0575 0.0683
Plasmodium falciparum protein kinase 7 0.0672 0.6613 0.6609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Brugia malayi jmjC domain containing protein 0.0015 0.0012 0.0014
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0178 0.1647 0.2477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0263 0.0786
Loa Loa (eye worm) sugar transporter 0.0033 0.0195 0.022
Mycobacterium ulcerans integral membrane transport protein 0.0033 0.0195 0.0929
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0301 0.0346
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.015 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0514 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1089 0.1362
Loa Loa (eye worm) hypothetical protein 0.0492 0.4809 0.5699
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.012 0.107 0.1602
Onchocerca volvulus 0.0019 0.0055 0.0047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0263 0.429
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0046 0.0113
Schistosoma mansoni importin beta-1 0.0028 0.014 0.0162
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.1004 0.1254
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0174
Schistosoma mansoni hypothetical protein 0.0065 0.0514 0.0635
Echinococcus granulosus snurportin 1 0.0298 0.2855 0.3595
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0051 0.0028
Brugia malayi hypothetical protein 0.0029 0.0154 0.0183
Schistosoma mansoni zinc finger protein 0.0042 0.0278 0.0337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Plasmodium vivax importin-beta 2, putative 0.0028 0.014 0.0128
Loa Loa (eye worm) hypothetical protein 0.0211 0.198 0.2339
Loa Loa (eye worm) hypothetical protein 0.0178 0.1647 0.1944
Loa Loa (eye worm) runx1 0.0062 0.048 0.0559
Trypanosoma brucei THT1 - hexose transporter, putative 0.0074 0.06 0.1829
Brugia malayi glutathione reductase 0.0055 0.0412 0.0488
Echinococcus multilocularis synaptic vesicle 2 protein 0.0033 0.0195 0.0197
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0124 0.1103 0.6605
Plasmodium falciparum thioredoxin reductase 0.0055 0.0412 0.04
Brugia malayi lysyl-tRNA synthetase 0.0053 0.0392 0.0465
Echinococcus multilocularis muscleblind protein 0.016 0.1472 0.1566
Onchocerca volvulus 0.0033 0.0195 0.0193
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0071 0.0075
Loa Loa (eye worm) fibroinase 0.0019 0.0055 0.0054
Echinococcus multilocularis snurportin 1 0.0298 0.2855 0.305
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0601 0.0615
Entamoeba histolytica Ran family GTPase 0.0021 0.0066 0.0948
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0195 0.0193
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0045
Toxoplasma gondii FATC domain-containing protein 0.0029 0.015 0.0209
Trichomonas vaginalis glucose transporter, putative 0.0074 0.06 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0055 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0055 0.014
Echinococcus granulosus solute carrier family 22 0.0033 0.0195 0.0232
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0012 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0353 0.0432
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0071 0.0575 0.0683
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0597 0.1821
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0154 0.0447
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0124 0.1103 0.138
Brugia malayi Probable ClpP-like protease 0.0178 0.1647 0.1953
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0195 0.0231
Schistosoma mansoni hypothetical protein 0.0518 0.5066 0.6391
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0074 0.0601 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1929 0.228
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1119 0.6746
Schistosoma mansoni glucose transport protein 0.0237 0.2246 0.2825
Schistosoma mansoni lysyl-tRNA synthetase 0.0053 0.0392 0.0481
Toxoplasma gondii melibiase subfamily protein 0.0114 0.1004 0.1503
Brugia malayi hypothetical protein 0.0492 0.4809 0.5704
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0012 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Echinococcus granulosus caspase 3 0.0152 0.1388 0.174
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0055 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0263 0.0264
Echinococcus granulosus Sugar transporter ERD6 protein 0.0033 0.0195 0.0232
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.015 0.0148
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0056
Brugia malayi Importin beta-1 subunit 0.0028 0.014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0058 0.0441 0.0512
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Brugia malayi hypothetical protein 0.0211 0.198 0.2348
Plasmodium vivax lysine--tRNA ligase, putative 0.0053 0.0392 0.0381
Schistosoma mansoni ap endonuclease 0.0019 0.0046 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Plasmodium vivax glutathione reductase, putative 0.0055 0.0412 0.04
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0286 0.0295
Loa Loa (eye worm) hypothetical protein 0.0159 0.1453 0.1715
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0263 0.0786
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.1043 0.1304
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1119 0.6746
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2825
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0055 0.0047
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2825
Onchocerca volvulus 0.0033 0.0195 0.0193
Trypanosoma brucei protein kinase, putative 0.012 0.107 0.3287
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0005
Onchocerca volvulus 0.0033 0.0195 0.0193
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0146 0.1328 0.1664
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1021 0.1201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0071 0.0189
Brugia malayi Sugar transporter family protein 0.0237 0.2246 0.2665
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0053 0.0392 0.0602
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0412 0.0429
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.1089 0.1362
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0055 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0605 0.1845
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0051 0.0127
Schistosoma mansoni microtubule-associated protein tau 0.0802 0.7921 1
Giardia lamblia GTOR 0.0021 0.0071 0.0237
Trichomonas vaginalis set domain proteins, putative 0.097 0.9613 1
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.3234 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0342 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0046 0.0044
Brugia malayi Bromodomain containing protein 0.0081 0.0679 0.0805
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0071 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Plasmodium vivax proline--tRNA ligase, putative 0.0083 0.0694 0.0683
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1119 0.6746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0371 0.3592 0.373
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0263 0.429
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.001 0.0012
Leishmania major protein kinase, putative 0.0074 0.0601 0.1833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.015 0.1372 0.1618
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0051 0.0043
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.015 0.0174
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0087 0.008
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0195 0.0278
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.014 0.0404
Schistosoma mansoni hypothetical protein 0.0298 0.2855 0.3595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0263 0.0264
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Leishmania major cathepsin L-like protease 0.0074 0.0605 0.1845
Loa Loa (eye worm) sugar transporter 0.0237 0.2246 0.2656
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0537 0.5258 0.6233
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Echinococcus multilocularis apoptotic protease activating factor 1 0.0211 0.198 0.2111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0021 0.0015
Brugia malayi follicle stimulating hormone receptor 0.0489 0.4778 0.5668
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0597 0.0697
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0053 0.0392 0.2161
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Echinococcus multilocularis peptidase Clp (S14 family) 0.0117 0.1031 0.1094
Schistosoma mansoni peptidase Clp (S14 family) 0.0178 0.1647 0.2067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0353 0.0419
Brugia malayi major facilitator superfamily protein 0.0033 0.0195 0.0231
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0298 0.2856 0.3052
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0051 0.0127
Onchocerca volvulus 0.0492 0.4809 0.4997
Toxoplasma gondii lysine-tRNA ligase 0.0053 0.0392 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Toxoplasma gondii sugar transporter ST1 0.0033 0.0195 0.0278
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0071 0.0189
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.168 0.1993
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0514 0.0539
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.168 0.179
Onchocerca volvulus 0.0033 0.0195 0.0193
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.015 0.0433
Plasmodium vivax vivapain-2 0.0019 0.0055 0.0043
Treponema pallidum NADH oxidase 0.0019 0.0051 0.0028
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.1304
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0154 0.0447
Echinococcus multilocularis microtubule associated protein 2 0.0802 0.7921 0.8486
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0263 0.0264
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0597 0.1821
Loa Loa (eye worm) hypothetical protein 0.0029 0.0154 0.0171
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0127
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0597 0.074
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0012 0.0006
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0071 0.019
Trypanosoma brucei sugar transporter, putative 0.0033 0.0195 0.0574
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0087 0.008
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0195 0.0231
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0114 0.1004 0.1065
Leishmania major cathepsin L-like protease 0.0019 0.0055 0.014
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Echinococcus granulosus importin subunit beta 1 0.0028 0.014 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0623 0.0772
Schistosoma mansoni hypothetical protein 0.0141 0.1274 0.1596
Chlamydia trachomatis proline--tRNA ligase 0.0025 0.0112 0.0385
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0114 0.1004 0.1065
Plasmodium falciparum glutathione reductase 0.0055 0.0412 0.04
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0632
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Leishmania major glucose transporter, lmgt1 0.0074 0.06 0.1829
Entamoeba histolytica protein kinase, putative 0.0074 0.0601 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0195 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0039
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0601 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1328 0.1372
Onchocerca volvulus Glucosylceramidase homolog 0.0352 0.3402 0.3532
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.1637 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0071 0.0575 0.0589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.015 0.0145
Echinococcus multilocularis geminin 0.0518 0.5066 0.5423
Trichomonas vaginalis glucosylceramidase, putative 0.0352 0.3402 0.3532
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0116
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0342 0.0354
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0046 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0605 0.1845
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1328 0.1994
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0146 0.1328 0.1994
Loa Loa (eye worm) hypothetical protein 0.0082 0.068 0.0796
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0237 0.2246 0.2825
Echinococcus granulosus mitogen activated protein kinase 0.012 0.107 0.1338
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Onchocerca volvulus Putative transporter 0.0033 0.0195 0.0193
Echinococcus multilocularis zinc finger protein 0.0042 0.0278 0.0286
Trypanosoma brucei metacaspase MCA2 0.0146 0.1328 0.4088
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0074 0.0601 0.0702
Echinococcus granulosus serine protein kinase ATM 0.0029 0.015 0.0174
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0071 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.3234 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0694 0.2122
Brugia malayi Cathepsin L-like precursor 0.0019 0.0055 0.0065
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0117 0.1031 0.619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0353 0.0432
Loa Loa (eye worm) hypothetical protein 0.0146 0.1328 0.1565
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.3234 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0071 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0046 0.0113
Entamoeba histolytica protein kinase, putative 0.0074 0.0601 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.014 0.0404
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0263 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0055 0.0043
Brugia malayi hypothetical protein 0.0033 0.0195 0.0231
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0385 0.3727 0.5627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0353 0.0408
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0046 0.0038
Onchocerca volvulus 0.0033 0.0195 0.0193
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1456 0.4487
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0055 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0071 0.0084
Schistosoma mansoni ran 0.0021 0.0066 0.0068
Loa Loa (eye worm) hypothetical protein 0.016 0.1472 0.1736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0605 0.1845
Plasmodium falciparum thioredoxin reductase 0.0019 0.0051 0.0039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0178 0.1647 0.1754
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0237 0.2246 0.2397
Trypanosoma brucei glucose transporter, putative 0.0074 0.06 0.1829
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0984 0.1157
Onchocerca volvulus Cell death protein 3 homolog 0.0357 0.3448 0.358
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1119 0.6746
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1021 0.1201
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0071 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Plasmodium falciparum metacaspase-like protein 0.0146 0.1328 0.1318
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0055 0.0043
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0055 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.5258 0.5465
Toxoplasma gondii facilitative glucose transporter GT1 0.0237 0.2246 0.3385
Echinococcus granulosus zinc finger protein 0.0042 0.0278 0.0337
Trichomonas vaginalis sugar transporter, putative 0.0074 0.06 0.0614
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0472 0.0548
Onchocerca volvulus 0.0019 0.0055 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0237 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0071 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0263 0.0264
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0124 0.1103 0.1309
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Toxoplasma gondii exonuclease III APE 0.0019 0.0046 0.0052
Leishmania major myo-inositol/proton symporter (MIT) 0.0033 0.0195 0.0574
Trichomonas vaginalis CMGC family protein kinase 0.012 0.107 0.1103
Onchocerca volvulus 0.0033 0.0195 0.0193
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0124 0.1103 0.1171
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0178 0.1647 0.2067
Brugia malayi Melibiase family protein 0.0076 0.0623 0.0739
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0083 0.0694 0.2122
Echinococcus multilocularis caspase 0.0298 0.2856 0.3052
Leishmania major glucose transporter, lmgt2 0.0074 0.06 0.1829
Trypanosoma brucei Metacaspase-4 0.0146 0.1328 0.4088
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0083 0.0694 0.2122
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0146 0.1328 0.1372
Leishmania major cathepsin L-like protease 0.0019 0.0055 0.014
Plasmodium falciparum calcium-dependent protein kinase 4 0.0074 0.0601 0.059
Toxoplasma gondii sugar transporter ST2 0.0033 0.0195 0.0278
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0051 0.0039
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0412 0.2297
Trichomonas vaginalis sugar transporter, putative 0.0074 0.06 0.0614
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0033 0.0195 0.0934
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0067
Loa Loa (eye worm) hypothetical protein 0.0091 0.0772 0.0905
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0071 0.0072
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.012 0.107 0.3287
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0055 0.0046
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0154 0.0142
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0051 0.0028
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0033 0.0195 0.0574
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0051 0.0127
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0071 0.0575 0.0713
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.1274 0.1512
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0055 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0601 0.0745
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0116
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0178 0.1647 1
Giardia lamblia Lysyl-tRNA synthetase 0.0053 0.0392 0.3379
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0046 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0195 0.0193
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0051 0.0127
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0431 0.0449
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0263 0.0312

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 3.62 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.77 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.97 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 6 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 66 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 90 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 6 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 66 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 90 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.1 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.78867 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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