Detailed information for compound 605565

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.811 | Formula: C17H19ClN4O3
  • H donors: 3 H acceptors: 1 LogP: 3.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CNNc2nc3c([nH]2)ccc(c3)Cl)cc(c1OC)OC
  • InChi: 1S/C17H19ClN4O3/c1-23-14-6-10(7-15(24-2)16(14)25-3)9-19-22-17-20-12-5-4-11(18)8-13(12)21-17/h4-8,19H,9H2,1-3H3,(H2,20,21,22)
  • InChiKey: MIWVHBAYCDKHFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.125994 0.422253 0.539534
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013821 0.00214798 0.0270372
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0516949 0.171768 0.219476
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013821 0.00214798 0.0270372
Loa Loa (eye worm) hypothetical protein 0.0126174 0.0400256 0.0400256
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013821 0.00214798 0.0270372
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0516949 0.171768 0.171768
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Brugia malayi AKH receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis acylamino acid releasing enzyme 0.00106512 0.00107934 0.00107934
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013821 0.00214798 0.0953353
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0516949 0.171768 0.171768
Loa Loa (eye worm) hypothetical protein 0.158589 0.53214 0.53214
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Plasmodium falciparum phosphodiesterase delta, putative 0.0242292 0.0791725 0.0999212
Brugia malayi cathepsin Z-like cysteine proteinase 0.0548387 0.182366 0.182366
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0272264 0.0892767 0.0892767
Brugia malayi Cathepsin L-like cysteine proteinase 0.158589 0.53214 0.53214
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0268064 0.087861 0.112264
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Leishmania major protein kinase, putative 0.0010727 0.0011049 0.00141178
Loa Loa (eye worm) CAMK/PKD protein kinase 0.00197058 0.00413192 0.00413192
Plasmodium vivax serine-repeat antigen (SERA) 0.0516949 0.171768 0.218398
Schistosoma mansoni voltage-gated potassium channel 0.00219329 0.00488275 0.00488275
Brugia malayi Papain family cysteine protease containing protein 0.125994 0.422253 0.422253
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Loa Loa (eye worm) hypothetical protein 0.00393474 0.0107537 0.0107537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158589 0.53214 0.679942
Trypanosoma cruzi hypothetical protein, conserved 0.00106512 0.00107934 0.00107934
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Schistosoma mansoni neuropeptide receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis conserved hypothetical protein 0.00475079 0.0135048 0.0172558
Giardia lamblia Cathepsin B precursor 0.0516949 0.171768 0.333886
Trichomonas vaginalis conserved hypothetical protein 0.0516949 0.171768 0.219476
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00238909 0.00554285 0.00708237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus multilocularis 0.0013821 0.00214798 0.00214798
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0516949 0.171768 0.171768
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.00499986 0.0143445 0.0143445
Brugia malayi Cytochrome P450 family protein 0.0013821 0.00214798 0.00214798
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.232889 0.782626 0.782626
Schistosoma mansoni hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) hypothetical protein 0.137007 0.459381 0.459381
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.297366 1 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0516949 0.171768 0.218398
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi hypothetical protein 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) hypothetical protein 0.158589 0.53214 0.53214
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cytochrome P450 0.0013821 0.00214798 0.00214798
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Onchocerca volvulus 0.232889 0.782626 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0262623 0.0860267 0.0860267
Entamoeba histolytica cysteine proteinase, putative 0.125994 0.422253 0.538898
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00238909 0.00554285 0.00554285
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0924296 0.309096 0.394112
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.125994 0.422253 0.422253
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.02898 0.0951888 0.121627
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0516949 0.171768 0.218398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Entamoeba histolytica cysteine proteinase, putative 0.125994 0.422253 0.538898
Echinococcus multilocularis neuropeptide receptor A26 0.00238909 0.00554285 0.00554285
Echinococcus granulosus tm gpcr rhodopsin 0.00238909 0.00554285 0.00554285
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0242292 0.0791725 0.0999212
Echinococcus granulosus cathepsin b 0.297366 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis g-protein coupled receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013821 0.00214798 0.0270372
Onchocerca volvulus Prolyl endopeptidase homolog 0.00106512 0.00107934 0.00137913
Trypanosoma brucei cAMP-specific phosphodiesterase 0.02898 0.0951888 0.120414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013821 0.00214798 0.0270372
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00238909 0.00554285 0.00554285
Echinococcus granulosus neuropeptide Y receptor 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Trichomonas vaginalis conserved hypothetical protein 0.0242292 0.0791725 0.101163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0268064 0.087861 0.112264
Echinococcus granulosus alpha 1A adrenergic receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.014625 0.0467937 0.0467937
Schistosoma mansoni hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.00106512 0.00107934 0.00137913
Leishmania major cytochrome p450-like protein 0.00166573 0.00310419 0.00396638
Onchocerca volvulus 0.232889 0.782626 1
Brugia malayi Protein kinase domain containing protein 0.00291272 0.00730815 0.00730815
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0272264 0.0892767 0.0892767
Plasmodium vivax unspecified product 0.0516949 0.171768 0.218398
Giardia lamblia Cathepsin B precursor 0.0516949 0.171768 0.333886
Echinococcus multilocularis G-protein coupled receptor, putative 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0307928 0.1013 0.129437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0260421 0.0852841 0.108972
Echinococcus multilocularis cathepsin b 0.297366 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0516949 0.171768 0.171768
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Onchocerca volvulus Neuropeptide F receptor homolog 0.00238909 0.00554285 0.00708237
Brugia malayi RE15519p 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.125994 0.422253 0.422253
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0242292 0.0791725 0.0999212
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013821 0.00214798 0.0270372
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.00499986 0.0143445 0.016973
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.152703 0.512296 0.654586
Trypanosoma cruzi major cysteine proteinase, putative 0.0516949 0.171768 0.171768
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.00106512 0.00107934 0.00137913
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.000790707 0.000154224 0.000154224
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Giardia lamblia Cathepsin B precursor 0.0548387 0.182366 0.354618
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00238909 0.00554285 0.00554285
Echinococcus granulosus cathepsin L 0.0516949 0.171768 0.171768
Echinococcus granulosus serotonin receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.232889 0.782626 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0025772 0.00617702 0.454772
Onchocerca volvulus 0.0516949 0.171768 0.219476
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0924296 0.309096 0.602518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Schistosoma mansoni cathepsin S (C01 family) 0.0516949 0.171768 0.171768
Onchocerca volvulus 0.0019556 0.00408142 0.00521503
Schistosoma mansoni alpha-1 adrenergic receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus transmembrane protease serine 3 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Onchocerca volvulus Cathepsin L homolog 0.232889 0.782626 1
Trypanosoma cruzi cysteine peptidase, putative 0.232889 0.782626 0.782626
Echinococcus multilocularis serotonin receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni opsin-like receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Brugia malayi neuropeptide F receptor 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013821 0.00214798 0.0953353
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Giardia lamblia Cathepsin L-like protease 0.0516949 0.171768 0.333886
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0516949 0.171768 0.218398
Schistosoma mansoni biogenic amine (5HT) receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus prolyl endopeptidase 0.00106512 0.00107934 0.00107934
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0516949 0.171768 0.218398
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0272264 0.0892767 0.0892767
Giardia lamblia Cathepsin B precursor 0.0516949 0.171768 0.333886
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.000744961 0 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.137007 0.459381 0.459381
Schistosoma mansoni neuropeptide receptor 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cysteine peptidase C (CPC) 0.152703 0.512296 0.654109
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0242292 0.0791725 0.0791725
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0548387 0.182366 0.233018
Echinococcus granulosus biogenic amine 5HT receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.00499986 0.0143445 0.0143445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00238909 0.00554285 0.00554285
Leishmania major cytochrome p450-like protein 0.0013821 0.00214798 0.00274458
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Plasmodium falciparum GAF domain-related protein, putative 0.0025772 0.00617702 0.00652255
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.297366 1 1
Schistosoma mansoni hypothetical protein 0.0013821 0.00214798 0.00214798
Echinococcus multilocularis fmrfamide receptor 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin L-like protease 0.0516949 0.171768 0.333886
Loa Loa (eye worm) cytochrome P450 0.0013821 0.00214798 0.00214798
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0516949 0.171768 0.171768
Echinococcus granulosus cathepsin b 0.297366 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Toxoplasma gondii hypothetical protein 0.0025772 0.00617702 0.00652255
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Loa Loa (eye worm) G-protein coupled receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) cytochrome P450 family protein 0.00166573 0.00310419 0.00310419
Schistosoma mansoni neuropeptide F-like receptor 0.00238909 0.00554285 0.00554285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Echinococcus granulosus tm gpcr rhodopsin 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013821 0.00214798 0.0953353
Trypanosoma cruzi cysteine peptidase, putative 0.125994 0.422253 0.422253
Giardia lamblia Hypothetical protein 0.0242292 0.0791725 0.152759
Loa Loa (eye worm) hypothetical protein 0.0043589 0.0121837 0.0121837
Schistosoma mansoni amine GPCR 0.00238909 0.00554285 0.00554285
Plasmodium vivax vivapain-1 0.125994 0.422253 0.538898
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00166573 0.00310419 0.0512296
Giardia lamblia Hypothetical protein 0.0516949 0.171768 0.333886
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.00181284 0.00360014 0.00360014
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.02898 0.0951888 0.0951888
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0516949 0.171768 0.171768
Schistosoma mansoni opsin-like receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus cathepsin L cysteine protease 0.125994 0.422253 0.422253
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi cysteine proteinase, putative 0.125994 0.422253 0.422253
Echinococcus granulosus allatostatin A receptor 0.00238909 0.00554285 0.00554285
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) neuropeptide F receptor 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans putative regulatory protein 0.0025772 0.00617702 0.128974
Giardia lamblia Cathepsin B precursor 0.152703 0.512296 1
Schistosoma mansoni hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi Trypsin family protein 0.0022968 0.00523172 0.00523172
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013821 0.00214798 0.0953353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.00439004 0.0122886 1
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013821 0.00214798 0.0270372
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Giardia lamblia Cysteine protease 0.0516949 0.171768 0.333886
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013821 0.00214798 0.0953353
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.112778 0.377697 0.377697
Echinococcus multilocularis sex peptide receptor 0.00238909 0.00554285 0.00554285
Mycobacterium leprae Conserved hypothetical protein 0.0013821 0.00214798 0.347738
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0268064 0.087861 0.112264
Loa Loa (eye worm) hypothetical protein 0.0043589 0.0121837 0.0121837
Echinococcus granulosus neuropeptides capa receptor 0.00238909 0.00554285 0.00554285
Giardia lamblia Cysteine protease 0.0516949 0.171768 0.333886
Loa Loa (eye worm) hypothetical protein 0.0742995 0.247974 0.247974
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.00106512 0.00107934 0.00107934
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0307928 0.1013 0.129437
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.125994 0.422253 0.422253
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Echinococcus multilocularis neuropeptide receptor 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Conserved hypothetical protein 0.00181284 0.00360014 0.224885
Entamoeba histolytica cysteine proteinase, putative 0.125994 0.422253 0.538898
Schistosoma mansoni hypothetical protein 0.00238909 0.00554285 0.00554285
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.137007 0.459381 0.896492
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0118504 0.0374397 0.0374397
Schistosoma mansoni cathepsin C 0.0516949 0.171768 0.171768
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.137172 0.459935 0.587113
Brugia malayi Dopamine receptor protein 1 0.0126174 0.0400256 0.0400256
Schistosoma mansoni myosin xvIII 0.00238909 0.00554285 0.00554285
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022968 0.00523172 0.00523172
Brugia malayi Alpha-L-fucosidase family protein 0.00612319 0.0181316 0.0181316
Loa Loa (eye worm) hypothetical protein 0.0388542 0.128478 0.128478
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0307928 0.1013 0.129437
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Brugia malayi prolyl oligopeptidase family protein 0.00106512 0.00107934 0.00107934
Loa Loa (eye worm) trypsin family protein 0.0022968 0.00523172 0.00523172
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0548387 0.182366 0.182366
Brugia malayi Papain family cysteine protease containing protein 0.0516949 0.171768 0.171768
Loa Loa (eye worm) cathepsin B 0.152703 0.512296 0.512296
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.297366 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013821 0.00214798 0.00214798
Brugia malayi cathepsin L-like precursor 0.158589 0.53214 0.53214
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis g protein coupled receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis allatostatin A receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00198935 0.00419519 0.00419519
Trypanosoma cruzi cruzipain precursor, putative 0.232889 0.782626 0.782626
Loa Loa (eye worm) hypothetical protein 0.00192483 0.0039777 0.0039777
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0285881 0.0938676 0.0938676
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Echinococcus multilocularis neuropeptide Y receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Trypanosoma cruzi prolyl endopeptidase 0.00106512 0.00107934 0.00107934
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Onchocerca volvulus 0.232889 0.782626 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni neuropeptide F-like receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Schistosoma mansoni amine GPCR 0.00238909 0.00554285 0.00554285
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0262623 0.0860267 0.0860267
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0264028 0.0865003 0.110526
Echinococcus multilocularis neuropeptide Y receptor 0.00238909 0.00554285 0.00554285
Plasmodium falciparum cysteine proteinase falcipain 1 0.125994 0.422253 0.538898
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013821 0.00214798 0.00136734
Echinococcus granulosus 7TM GPCR rhodopsin 0.00238909 0.00554285 0.00554285
Echinococcus granulosus g protein coupled receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Toxoplasma gondii hypothetical protein 0.0025772 0.00617702 0.00652255
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00246059 0.00578392 0.0073904
Echinococcus granulosus enteropeptidase 0.0022968 0.00523172 0.00523172
Schistosoma mansoni cathepsin F (C01 family) 0.232889 0.782626 0.782626
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0242292 0.0791725 0.0791725
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.02898 0.0951888 0.0951888
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.125994 0.422253 0.422253
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022968 0.00523172 0.00523172
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013821 0.00214798 0.0953353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cAMP-specific phosphodiesterase 0.02898 0.0951888 0.120414
Trypanosoma cruzi cytochrome P450, putative 0.00166573 0.00310419 0.00310419
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013821 0.00214798 0.0953353
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Echinococcus multilocularis mitogen activated protein kinase 11 0.00235453 0.00542634 0.00542634
Echinococcus granulosus cathepsin l cysteine peptidase 0.232889 0.782626 0.782626
Brugia malayi cathepsin L precursor 0.0516949 0.171768 0.171768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013821 0.00214798 0.00136734
Echinococcus granulosus Dipeptidyl peptidase 9 0.00499986 0.0143445 0.0143445
Leishmania major oligopeptidase b 0.00106512 0.00107934 0.00137913
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013821 0.00214798 0.0953353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis g protein coupled receptor 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.00175217 0.00339561 0.00433874
Leishmania major hypothetical protein, conserved 0.00181284 0.00360014 0.00460008
Trypanosoma cruzi oligopeptidase b 0.00106512 0.00107934 0.00107934
Brugia malayi Cathepsin L-like precursor 0.158589 0.53214 0.53214
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Echinococcus granulosus G protein coupled receptor 139 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Schistosoma mansoni growth hormone secretagogue receptor 0.00238909 0.00554285 0.00554285
Brugia malayi larval opioid receptor 0.00238909 0.00554285 0.00554285
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0742995 0.247974 0.247974
Echinococcus multilocularis mitogen activated protein kinase 14 0.00235453 0.00542634 0.00542634
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0242292 0.0791725 0.0791725
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.000790707 0.000154224 0.000154224
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0516949 0.171768 0.171768
Loa Loa (eye worm) hypothetical protein 0.0282213 0.0926309 0.0926309
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0127891 0.0406043 0.0406043
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cathepsin B (C01 family) 0.0516949 0.171768 0.171768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0516949 0.171768 0.171768
Giardia lamblia Cysteine protease 0.0516949 0.171768 0.333886
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.00235453 0.00542634 0.00542634
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.02898 0.0951888 0.0951888
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Loa Loa (eye worm) hypothetical protein 0.00106512 0.00107934 0.00107934
Brugia malayi fibroinase precursor 0.0516949 0.171768 0.171768
Echinococcus multilocularis somatostatin receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.02898 0.0951888 0.0951888
Plasmodium falciparum serine repeat antigen 9 0.0516949 0.171768 0.218398
Echinococcus multilocularis fmrfamide receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0285881 0.0938676 0.0938676
Loa Loa (eye worm) TYRA-2 protein 0.00238909 0.00554285 0.00554285
Echinococcus granulosus neuropeptides capa receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) cytochrome P450 family protein 0.00166573 0.00310419 0.00310419
Brugia malayi prolyl oligopeptidase family protein 0.00499986 0.0143445 0.0143445
Loa Loa (eye worm) cytochrome P450 family protein 0.00338999 0.00891718 0.00891718
Plasmodium falciparum serine repeat antigen 6 0.0516949 0.171768 0.218398
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Loa Loa (eye worm) CYP4Cod1 0.00166573 0.00310419 0.00310419
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.00499986 0.0143445 0.016973
Brugia malayi Serotonin receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis CAMK family protein kinase 0.00291272 0.00730815 0.00933799
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Mycobacterium ulcerans alpha-L-fucosidase 0.0127891 0.0406043 1
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0282213 0.0926309 0.0926309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.00106512 0.00107934 0.00107934
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Plasmodium vivax unspecified product 0.0742995 0.247974 0.315906
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0924296 0.309096 0.394112
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00238909 0.00554285 0.00554285
Brugia malayi G-protein coupled receptor 0.00238909 0.00554285 0.00554285
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0516949 0.171768 0.219476
Schistosoma mansoni biogenic amine receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni histamine h1 receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0516949 0.171768 0.171768
Entamoeba histolytica cysteine proteinase, putative 0.125994 0.422253 0.538898
Schistosoma mansoni neuropeptide receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi Cytochrome P450 family protein 0.00166573 0.00310419 0.00310419
Echinococcus granulosus biogenic amine 5HT receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00198935 0.00419519 0.00419519
Brugia malayi G-protein coupled receptor 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013821 0.00214798 0.0270372
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0516949 0.171768 0.333886
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) PDE1B protein 0.0306982 0.100982 0.100982
Echinococcus multilocularis neuropeptide FF receptor 2 0.00238909 0.00554285 0.00554285
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.00499986 0.0143445 0.0143445
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Brugia malayi Papain family cysteine protease containing protein 0.0516949 0.171768 0.171768
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0924296 0.309096 0.394112
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0516949 0.171768 0.218398
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Mycobacterium leprae putative cytochrome p450 0.0013821 0.00214798 0.347738
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Schistosoma mansoni amine GPCR 0.00238909 0.00554285 0.00554285
Brugia malayi P38 map kinase family protein 2 0.00235453 0.00542634 0.00542634
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus multilocularis neuropeptide s receptor 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Plasmodium falciparum serine repeat antigen 1 0.0516949 0.171768 0.218398
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.232889 0.782626 0.782626
Schistosoma mansoni neuropeptide receptor 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Mycobacterium ulcerans hypothetical protein 0.0022968 0.00523172 0.105057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0243936 0.0797268 0.10063
Echinococcus multilocularis cathepsin L cysteine protease 0.232889 0.782626 0.782626
Loa Loa (eye worm) hypothetical protein 0.297366 1 1
Brugia malayi Trypsin-like protease protein 5 0.0022968 0.00523172 0.00523172
Leishmania major hypothetical protein, conserved 0.0242292 0.0791725 0.101163
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Echinococcus granulosus fmrfamide receptor 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.0022968 0.00523172 0.00668483
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Brugia malayi Dopamine receptor protein 2 0.00238909 0.00554285 0.00554285
Plasmodium vivax unspecified product 0.125994 0.422253 0.538898
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin B precursor 0.152703 0.512296 1
Entamoeba histolytica cysteine proteinase, putative 0.232889 0.782626 1
Plasmodium vivax hypothetical protein, conserved 0.0025772 0.00617702 0.00652255
Brugia malayi Cytochrome P450 family protein 0.00338999 0.00891718 0.00891718
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0306982 0.100982 0.100982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Echinococcus granulosus neuropeptide receptor A26 0.00238909 0.00554285 0.00554285
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.00499986 0.0143445 0.016973
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0924296 0.309096 0.394112
Brugia malayi G protein-coupled receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis neuropeptide receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00238909 0.00554285 0.00554285
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Entamoeba histolytica cysteine proteinase 2 0.125994 0.422253 0.538898
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.02898 0.0951888 0.121627
Schistosoma mansoni adenoreceptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.158589 0.53214 0.679942
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.00439004 0.0122886 0.283601
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) prolyl oligopeptidase 0.0151646 0.0486129 0.0486129
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013821 0.00214798 0.0953353
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.00291272 0.00730815 0.00730815
Brugia malayi cathepsin L-like cysteine proteinase 0.0516949 0.171768 0.171768
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Brugia malayi Papain family cysteine protease containing protein 0.232889 0.782626 0.782626
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.234298 0.787379 0.787379
Brugia malayi cathepsin Z-like cysteine proteinase 0.0548387 0.182366 0.182366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis Mastin 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00182491 0.00364085 0.0046521
Schistosoma mansoni biogenic amine receptor 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans putative regulatory protein 0.0025772 0.00617702 0.128974
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.137007 0.459381 0.459381
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0151646 0.0486129 0.0486129
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Plasmodium falciparum cysteine proteinase falcipain 3 0.232889 0.782626 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis neuropeptides capa receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0306982 0.100982 0.100982
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00238909 0.00554285 0.00554285
Plasmodium falciparum serine repeat antigen 8 0.0516949 0.171768 0.218398
Onchocerca volvulus 0.232889 0.782626 1
Schistosoma mansoni amine GPCR 0.00238909 0.00554285 0.00554285
Giardia lamblia Cathepsin B precursor 0.0516949 0.171768 0.333886
Brugia malayi Dopamine receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0516949 0.171768 0.219476
Toxoplasma gondii cathepsin B 0.152703 0.512296 0.654109
Onchocerca volvulus Cathepsin L homolog 0.232889 0.782626 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0264028 0.0865003 0.0865003
Brugia malayi putative neuropeptide receptor NPR1 0.00238909 0.00554285 0.00554285
Mycobacterium leprae conserved hypothetical protein 0.0025772 0.00617702 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.232889 0.782626 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0548387 0.182366 0.233018
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013821 0.00214798 0.00214798
Loa Loa (eye worm) hypothetical protein 0.00170736 0.00324452 0.00324452
Echinococcus granulosus cytochrome P450 2K1 0.0013821 0.00214798 0.00214798
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00198935 0.00419519 0.00419519
Plasmodium vivax vivapain-3 0.125994 0.422253 0.538898
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00246059 0.00578392 0.0073904
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.00235453 0.00542634 0.00556205
Leishmania major hypothetical protein, conserved 0.0242292 0.0791725 0.101163
Loa Loa (eye worm) hypothetical protein 0.232889 0.782626 0.782626
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Onchocerca volvulus 0.232889 0.782626 1
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Echinococcus multilocularis cysteine protease 0.232889 0.782626 0.782626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0671051 0.22372 0.435511
Trichomonas vaginalis CAMK family protein kinase 0.00291272 0.00730815 0.00933799
Brugia malayi cathepsin F-like cysteine proteinase 0.0516949 0.171768 0.171768
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.232889 0.782626 0.782626
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.297366 1 1
Echinococcus granulosus cysteine protease 0.125994 0.422253 0.422253
Brugia malayi GnHR receptor homolog 0.00238909 0.00554285 0.00554285
Plasmodium vivax vivapain-2 0.232889 0.782626 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.00106512 0.00107934 0.00107934
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.000790707 0.000154224 0.000154224
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.125994 0.422253 0.538898
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi putative neuropeptide receptor 0.00238909 0.00554285 0.00554285
Plasmodium vivax serine-repeat antigen (SERA) 0.0516949 0.171768 0.218398
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis cathepsin L cysteine protease 0.232889 0.782626 0.782626
Loa Loa (eye worm) hypothetical protein 0.0019556 0.00408142 0.00408142
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Schistosoma mansoni protein kinase C mu 0.00197058 0.00413192 0.00413192
Giardia lamblia Hypothetical protein 0.0516949 0.171768 0.333886
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0272264 0.0892767 0.11285
Echinococcus multilocularis orexin receptor type 2 0.00238909 0.00554285 0.00554285
Giardia lamblia Kinase, TTK 0.00291272 0.00730815 0.0121843
Echinococcus multilocularis cathepsin b 0.297366 1 1
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.137007 0.459381 0.459381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.00181284 0.00360014 0.00360014
Echinococcus multilocularis cathepsin L 0.0516949 0.171768 0.171768
Plasmodium falciparum cysteine proteinase falcipain 2b 0.232889 0.782626 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.00235453 0.00542634 0.0069335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Trypanosoma cruzi cysteine proteinase, putative 0.125994 0.422253 0.422253
Schistosoma mansoni amine GPCR 0.00238909 0.00554285 0.00554285
Plasmodium falciparum serine repeat antigen 5 0.0516949 0.171768 0.218398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.125994 0.422253 0.539534
Echinococcus granulosus neuropeptide receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus g protein coupled receptor 0.00238909 0.00554285 0.00554285
Toxoplasma gondii preprocathepsin c precursor, putative 0.0924296 0.309096 0.394112
Plasmodium vivax phosphodiesterase gamma, putative 0.0242292 0.0791725 0.0999212
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0516949 0.171768 0.218398
Toxoplasma gondii cathepsin CPC2 0.0671051 0.22372 0.284872
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.00106512 0.00107934 0.00137913
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013821 0.00214798 0.0270372
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0306982 0.100982 0.100982
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0242292 0.0791725 0.0791725
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0151646 0.0486129 0.0621152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.00924168 0.028645 0.028645
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013821 0.00214798 0.0270372
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013821 0.00214798 0.0270372
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus granulosus cathepsin l1 0.232889 0.782626 0.782626
Trypanosoma cruzi hypothetical protein, conserved 0.00106512 0.00107934 0.00107934
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0548387 0.182366 0.233018
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0516949 0.171768 0.218398
Toxoplasma gondii cathepsin CPL 0.232889 0.782626 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.232889 0.782626 0.782626
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Giardia lamblia Cathepsin L precursor 0.0516949 0.171768 0.333886
Echinococcus granulosus tachykinin peptides receptor 99D 0.00238909 0.00554285 0.00554285
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0285881 0.0938676 0.0938676
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.000790707 0.000154224 0.000154224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516949 0.171768 0.219476
Echinococcus granulosus cathepsin l1 0.158589 0.53214 0.53214
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0516949 0.171768 0.219476
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.112778 0.377697 0.377697
Loa Loa (eye worm) hypothetical protein 0.00106512 0.00107934 0.00107934
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.00181284 0.00360014 0.0032254
Loa Loa (eye worm) hypothetical protein 0.00962226 0.029928 0.029928
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Echinococcus granulosus neuropeptide FF receptor 2 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00106512 0.00107934 0.00107934
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus granulosus cathepsin L cysteine proteinase 0.232889 0.782626 0.782626
Echinococcus multilocularis serotonin receptor 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi cysteine peptidase, putative 0.232889 0.782626 0.782626
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Brugia malayi follicle stimulating hormone receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cathepsin s 0.0742995 0.247974 0.247974
Leishmania major protein kinase, putative 0.000790707 0.000154224 0.000197059
Echinococcus multilocularis prolyl endopeptidase 0.00106512 0.00107934 0.00107934
Echinococcus granulosus tm gpcr rhodopsin 0.00238909 0.00554285 0.00554285
Plasmodium falciparum cysteine proteinase falcipain 2a 0.232889 0.782626 1
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Giardia lamblia Encystation-specific protease 0.0671051 0.22372 0.435511
Echinococcus granulosus acylamino acid releasing enzyme 0.00106512 0.00107934 0.00107934
Echinococcus granulosus g protein coupled receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni biogenic amine (5HT) receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni hypothetical protein 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00238909 0.00554285 0.00554285
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.00106512 0.00107934 0.00137913
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Brugia malayi prolyl oligopeptidase family protein 0.00106512 0.00107934 0.00107934
Loa Loa (eye worm) hypothetical protein 0.0043589 0.0121837 0.0121837
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.02898 0.0951888 0.0951888
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.00927365 0.0287528 0.0287528
Brugia malayi neuropeptide F receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Cathepsin L-like precursor 0.158589 0.53214 0.53214
Trypanosoma cruzi cysteine peptidase, putative 0.232889 0.782626 0.782626
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Trypanosoma cruzi cysteine peptidase, putative 0.0742995 0.247974 0.247974
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0516949 0.171768 0.219476
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Toxoplasma gondii GAF domain-containing protein 0.0025772 0.00617702 0.00652255
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.112778 0.377697 0.377697
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013821 0.00214798 0.0953353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.00106512 0.00107934 0.174735
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013821 0.00214798 0.0953353
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Entamoeba histolytica cysteine proteinase, putative 0.232889 0.782626 1
Trichomonas vaginalis conserved hypothetical protein 0.0025772 0.00617702 0.00789268
Brugia malayi Protein kinase domain containing protein 0.00924168 0.028645 0.028645
Onchocerca volvulus 0.232889 0.782626 1
Brugia malayi cytochrome P450 0.0013821 0.00214798 0.00214798
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Loa Loa (eye worm) G-protein coupled receptor 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cytochrome P450, putative 0.00166573 0.00310419 0.00259082
Echinococcus granulosus Mastin 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0260421 0.0852841 0.108972
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00182491 0.00364085 0.0046521
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00198935 0.00419519 0.00419519
Trypanosoma cruzi cysteine protease, putative 0.125994 0.422253 0.422253
Echinococcus granulosus peptide allatostatin:somatostatin 0.00238909 0.00554285 0.00554285
Brugia malayi Cytochrome P450 family protein 0.00166573 0.00310419 0.00310419
Echinococcus multilocularis glycoprotein Antigen 5 0.0022968 0.00523172 0.00523172
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) alpha-L-fucosidase 0.00612319 0.0181316 0.0181316
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0242292 0.0791725 0.0791725
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.152703 0.512296 0.654586
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0262623 0.0860267 0.0860267
Trichomonas vaginalis conserved hypothetical protein 0.00475079 0.0135048 0.0172558
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.00235453 0.00542634 0.00542634
Loa Loa (eye worm) hypothetical protein 0.0516949 0.171768 0.171768
Echinococcus multilocularis transmembrane protease serine 3 0.0022968 0.00523172 0.00523172
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013821 0.00214798 0.0270372
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.00291272 0.00730815 0.00730815
Brugia malayi prolyl oligopeptidase family protein 0.0151646 0.0486129 0.0486129
Schistosoma mansoni hypothetical protein 0.0022968 0.00523172 0.00523172
Brugia malayi cathepsin F-like cysteine proteinase 0.0742995 0.247974 0.247974
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013821 0.00214798 0.0953353
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013821 0.00214798 0.0953353
Schistosoma mansoni alpha-l-fucosidase 0.00612319 0.0181316 0.0181316
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Plasmodium falciparum serine repeat antigen 7 0.0516949 0.171768 0.218398
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013821 0.00214798 0.0270372
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0671051 0.22372 0.284872
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Plasmodium vivax vivapain-2 0.232889 0.782626 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013821 0.00214798 0.0953353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0262623 0.0860267 0.108691
Loa Loa (eye worm) prolyl oligopeptidase 0.00106512 0.00107934 0.00107934
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.00106512 0.00107934 0.00107934
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Tachykinin-like peptides receptor 99D 0.00238909 0.00554285 0.00554285
Toxoplasma gondii cathepsin CPC1 0.0924296 0.309096 0.394112
Trichomonas vaginalis conserved hypothetical protein 0.00475079 0.0135048 0.0172558
Brugia malayi sulfakinin receptor protein 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0516949 0.171768 0.171768
Loa Loa (eye worm) hypothetical protein 0.158589 0.53214 0.53214
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.234298 0.787379 0.787379
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Trypanosoma cruzi oligopeptidase b 0.00106512 0.00107934 0.00107934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Entamoeba histolytica cysteine proteinase, putative 0.158589 0.53214 0.6795
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Brugia malayi Serotonin receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00238909 0.00554285 0.00554285
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0262623 0.0860267 0.108691
Brugia malayi hypothetical protein 0.00393474 0.0107537 0.0107537
Trypanosoma brucei hypothetical protein, conserved 0.0242292 0.0791725 0.0999212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Brugia malayi G protein-coupled receptor F59B2.13 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.125994 0.422253 0.538898
Plasmodium falciparum serine repeat antigen 4 0.0516949 0.171768 0.218398
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Loa Loa (eye worm) hypothetical protein 0.0285881 0.0938676 0.0938676
Plasmodium falciparum phosphodiesterase gamma, putative 0.0242292 0.0791725 0.0999212
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.00197058 0.00413192 0.00413192
Giardia lamblia Cysteine protease 0.0516949 0.171768 0.333886
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus granulosus neuropeptide Y receptor 0.00238909 0.00554285 0.00554285
Echinococcus granulosus cathepsin L 0.125994 0.422253 0.422253
Echinococcus granulosus rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.232889 0.782626 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0272264 0.0892767 0.11285
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Brugia malayi C1-like domain containing protein 0.00197058 0.00413192 0.00413192
Leishmania major cytochrome p450-like protein 0.0013821 0.00214798 0.00274458
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0671051 0.22372 0.435511
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Brugia malayi ORL1-like opioid receptor 0.00238909 0.00554285 0.00554285
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis enteropeptidase 0.0022968 0.00523172 0.00523172
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013821 0.00214798 0.0270372
Echinococcus multilocularis cathepsin L 0.125994 0.422253 0.422253
Echinococcus granulosus neuropeptide receptor 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013821 0.00214798 0.0270372
Schistosoma mansoni opsin-like receptor 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0262623 0.0860267 0.0860267
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0262623 0.0860267 0.108691
Onchocerca volvulus 0.00192483 0.0039777 0.0050825
Trichomonas vaginalis conserved hypothetical protein 0.00106512 0.00107934 0.00137913
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0338515 0.111612 0.111612
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Echinococcus granulosus g-protein coupled receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) melatonin receptor type 1A 0.00238909 0.00554285 0.00554285
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Giardia lamblia hypothetical protein 0.0242292 0.0791725 0.152759
Echinococcus multilocularis cysteine protease 0.232889 0.782626 0.782626
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Echinococcus granulosus sex peptide receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.297366 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi prolyl oligopeptidase family protein 0.00106512 0.00107934 0.00107934
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.02898 0.0951888 0.0951888
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Brugia malayi hypothetical protein 0.00238909 0.00554285 0.00554285
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Brugia malayi Trypsin family protein 0.0022968 0.00523172 0.00523172
Plasmodium falciparum serine repeat antigen 2 0.0516949 0.171768 0.218398
Loa Loa (eye worm) hypothetical protein 0.0742995 0.247974 0.247974
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.00499986 0.0143445 0.0183287
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0516949 0.171768 0.219476
Echinococcus granulosus glycoprotein Antigen 5 0.0022968 0.00523172 0.00523172
Schistosoma mansoni cathepsin F (C01 family) 0.158589 0.53214 0.53214
Plasmodium falciparum serine repeat antigen 3 0.0516949 0.171768 0.218398
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0262623 0.0860267 0.108691
Trypanosoma cruzi cruzipain precursor, putative 0.0742995 0.247974 0.247974
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Onchocerca volvulus Cathepsin F homolog 0.232889 0.782626 1
Echinococcus granulosus orexin receptor type 2 0.00238909 0.00554285 0.00554285
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0242292 0.0791725 0.0791725
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi cysteine peptidase, putative 0.232889 0.782626 0.782626
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.137007 0.459381 0.459381
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0306982 0.100982 0.100982
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.00291272 0.00730815 0.00730815
Brugia malayi Cathepsin L-like precursor 0.0742995 0.247974 0.247974
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013821 0.00214798 0.0953353
Loa Loa (eye worm) hypothetical protein 0.00238909 0.00554285 0.00554285
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013821 0.00214798 0.0953353
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013821 0.00214798 0.0270372
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0262623 0.0860267 0.109921
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013821 0.00214798 0.00214798
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013821 0.00214798 0.0953353
Echinococcus granulosus somatostatin receptor 0.00238909 0.00554285 0.00554285
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0516949 0.171768 0.218398
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013821 0.00214798 0.0953353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0242292 0.0791725 0.0999212
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013821 0.00214798 0.0270372
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0742995 0.247974 0.247974
Loa Loa (eye worm) hypothetical protein 0.00704506 0.0212395 0.0212395
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.152703 0.512296 0.512296
Leishmania major cysteine peptidase A (CPA) 0.232889 0.782626 1
Schistosoma mansoni neuropeptide f receptor 76f 0.00238909 0.00554285 0.00554285
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013821 0.00214798 0.0270372
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013821 0.00214798 0.0270372
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis conserved hypothetical protein 0.0242292 0.0791725 0.101163
Giardia lamblia Cathepsin B precursor 0.152703 0.512296 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.00235453 0.00542634 0.00542634
Schistosoma mansoni voltage-gated potassium channel 0.00219329 0.00488275 0.00488275
Loa Loa (eye worm) hypothetical protein 0.00175217 0.00339561 0.00339561
Loa Loa (eye worm) hypothetical protein 0.0742995 0.247974 0.247974
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013821 0.00214798 0.0270372
Entamoeba histolytica cysteine proteinase 1, putative 0.125994 0.422253 0.538898
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.00291272 0.00730815 0.00933799
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.02898 0.0951888 0.121627
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0264028 0.0865003 0.110526
Entamoeba histolytica cysteine protease, putative 0.0516949 0.171768 0.218398
Loa Loa (eye worm) TKL/LRRK protein kinase 0.00924168 0.028645 0.028645
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.00106512 0.00107934 0.00107934
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00238909 0.00554285 0.00554285
Toxoplasma gondii hypothetical protein 0.00475079 0.0135048 0.0158986
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0282213 0.0926309 0.0926309
Echinococcus granulosus 7tm_1 domain containing protein 0.00238909 0.00554285 0.00554285
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis g protein coupled receptor 0.00238909 0.00554285 0.00554285
Loa Loa (eye worm) cysteine protease 0.232889 0.782626 0.782626
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0770195 0.257144 0.328566
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0516949 0.171768 0.171768
Loa Loa (eye worm) neuropeptide F receptor 0.00238909 0.00554285 0.00554285
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.158589 0.53214 0.53214
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022968 0.00523172 0.00523172
Entamoeba histolytica cysteine protease, putative 0.232889 0.782626 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.00179792 0.00354984 0.00354984
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013821 0.00214798 0.0953353
Onchocerca volvulus Cathepsin L homolog 0.0516949 0.171768 0.219476
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Echinococcus multilocularis rhodopsin orphan GPCR 0.00238909 0.00554285 0.00554285
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0151646 0.0486129 0.0486129
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0242292 0.0791725 0.0791725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Echinococcus granulosus neuropeptide s receptor 0.00238909 0.00554285 0.00554285
Schistosoma mansoni cathepsin F (C01 family) 0.232889 0.782626 0.782626
Loa Loa (eye worm) hypothetical protein 0.00175217 0.00339561 0.00339561
Schistosoma mansoni cercarial elastase (S01 family) 0.0022968 0.00523172 0.00523172
Loa Loa (eye worm) ctsf protein 0.232889 0.782626 0.782626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.00106512 0.00107934 0.00107934
Trypanosoma cruzi hypothetical protein, conserved 0.0242292 0.0791725 0.0791725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0671051 0.22372 0.284872
Leishmania major cathepsin L-like protease 0.232889 0.782626 1
Loa Loa (eye worm) fibroinase 0.232889 0.782626 0.782626
Trypanosoma cruzi cytochrome P450, putative 0.00166573 0.00310419 0.00310419
Echinococcus granulosus mitogen activated protein kinase 14 0.00235453 0.00542634 0.00542634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0548387 0.182366 0.233018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.152703 0.512296 0.512296
Onchocerca volvulus 0.158589 0.53214 0.679942
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.112778 0.377697 0.377697
Trypanosoma cruzi major cysteine proteinase, putative 0.0516949 0.171768 0.171768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00238909 0.00554285 0.00554285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0151646 0.0486129 0.0486129
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0338515 0.111612 0.111612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.232889 0.782626 1
Entamoeba histolytica hypothetical protein 0.0516949 0.171768 0.218398
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.137007 0.459381 0.459381
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0242292 0.0791725 0.0999212
Brugia malayi cathepsin B-like cysteine proteinase 0.297366 1 1
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Loa Loa (eye worm) hypothetical protein 0.0022968 0.00523172 0.00523172
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00238909 0.00554285 0.00554285
Schistosoma mansoni biogenic amine receptor 0.00238909 0.00554285 0.00554285
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022968 0.00523172 0.00523172
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0338515 0.111612 0.111612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Echinococcus granulosus dro:myosuppressin receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis G protein coupled receptor 139 0.00238909 0.00554285 0.00554285
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0388542 0.128478 0.128478
Loa Loa (eye worm) TTK protein kinase 0.00291272 0.00730815 0.00730815
Brugia malayi Trypsin family protein 0.0022968 0.00523172 0.00523172
Trichomonas vaginalis conserved hypothetical protein 0.0307928 0.1013 0.129437
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0127891 0.0406043 0.0406043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.232889 0.782626 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0924296 0.309096 0.309096
Brugia malayi Papain family cysteine protease containing protein 0.125994 0.422253 0.422253
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis mitogen activated protein kinase 14 0.00235453 0.00542634 0.00542634
Leishmania major cAMP-specific phosphodiesterase, putative 0.0242292 0.0791725 0.101163
Entamoeba histolytica cysteine protease, putative 0.125994 0.422253 0.538898
Brugia malayi Melatonin receptor type 1A 0.00238909 0.00554285 0.00554285
Echinococcus multilocularis Dipeptidyl peptidase 9 0.00499986 0.0143445 0.0143445
Trichomonas vaginalis conserved hypothetical protein 0.0516949 0.171768 0.219476
Brugia malayi Cathepsin L-like precursor 0.232889 0.782626 0.782626
Onchocerca volvulus 0.00238909 0.00554285 0.00708237
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0516949 0.171768 0.218398
Echinococcus multilocularis neuropeptides capa receptor 0.00238909 0.00554285 0.00554285
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013821 0.00214798 0.00274458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0516949 0.171768 0.171768
Echinococcus granulosus mitogen activated protein kinase 11 0.00235453 0.00542634 0.00542634
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013821 0.00214798 0.0953353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.232889 0.782626 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0242292 0.0791725 0.0791725
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.00235453 0.00542634 0.00542634

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.3075 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.3075 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.541 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.541 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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