Detailed information for compound 606044

Basic information

Technical information
  • TDR Targets ID: 606044
  • Name: 2-(4-ethoxyphenyl)-1,3-dimethyl-2H-benzimidaz ole
  • MW: 268.354 | Formula: C17H20N2O
  • H donors: 0 H acceptors: 0 LogP: 3.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C1N(C)c2c(N1C)cccc2
  • InChi: 1S/C17H20N2O/c1-4-20-14-11-9-13(10-12-14)17-18(2)15-7-5-6-8-16(15)19(17)3/h5-12,17H,4H2,1-3H3
  • InChiKey: NAUNGXOLCAXCQZ-UHFFFAOYSA-N  


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Synonyms

  • Oprea1_455821
  • ZINC00044034
  • Oprea1_706194
  • STOCK1S-56185
  • 2-(4-Ethoxy-phenyl)-1,3-dimethyl-2,3-dihydro-1H-benzoimidazole
  • BAS 00388319

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0378 0.287
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1295 0.5771
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0586 0.259
Toxoplasma gondii cathepsin CPL 0.0017 0.0165 0.0011
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0181 0.0249
Brugia malayi Thioredoxin reductase 0.0048 0.0748 0.1029
Brugia malayi Sugar transporter family protein 0.0126 0.2237 0.3077
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0872 0.1199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Leishmania major trypanothione reductase 0.0048 0.0748 0.5191
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0181 0.0205
Brugia malayi Cam kinase protein 1 0.0039 0.0577 0.0794
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0748 0.1029
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3711 0.5511
Onchocerca volvulus 0.0018 0.0181 0.0986
Onchocerca volvulus 0.0018 0.0181 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0059 0.0222
Treponema pallidum NADH oxidase 0.0017 0.0157 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0165 0.0227
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0378 0.0343
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0681 0.0812
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0562 0.0773
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Trypanosoma brucei glucose transporter 2A 0.0039 0.0586 0.4488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.2237 0.3077
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0139 0.0191
Loa Loa (eye worm) RNA binding protein 0.0392 0.7271 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0748 0.0659
Loa Loa (eye worm) hypothetical protein 0.0025 0.0321 0.0442
Toxoplasma gondii protein kinase, putative 0.0357 0.6605 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0577 0.4415
Leishmania major cathepsin L-like protease 0.0017 0.0165 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0165 0.0227
Trypanosoma brucei sugar transporter, putative 0.0018 0.0181 0.1333
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Loa Loa (eye worm) sugar transporter 0.0126 0.2237 0.3077
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0181 0.0249
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0074 0.0102
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0577 0.0651
Echinococcus granulosus cathepsin l1 0.0011 0.0059 0.0081
Trypanosoma cruzi hexose transporter, putative 0.0021 0.025 0.1871
Onchocerca volvulus 0.0077 0.1295 1
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0181 0.0249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Loa Loa (eye worm) hypothetical protein 0.0054 0.0872 0.1199
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0157 0.0217
Onchocerca volvulus 0.0054 0.087 0.6564
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0157 0.0217
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0181 1
Brugia malayi RNA binding protein 0.0392 0.7271 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0586 0.4488
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0378 0.2343
Leishmania major cathepsin L-like protease 0.0017 0.0165 0.0065
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0181 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Echinococcus granulosus cathepsin l1 0.0017 0.0165 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0562 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Trypanosoma cruzi hexose transporter 0.0039 0.0586 0.4488
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0586 0.4488
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0165 0.0227
Brugia malayi hypothetical protein 0.0018 0.0181 0.0249
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0727 0.1
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0181 0.0692
Onchocerca volvulus 0.0018 0.0181 0.0986
Toxoplasma gondii ABC1 family protein 0.0077 0.1295 0.1764
Mycobacterium tuberculosis Conserved protein 0.0077 0.1295 0.127
Leishmania major hypothetical protein, conserved 0.0018 0.0181 0.0205
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1295 0.1781
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0562 0.0773
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0059 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Echinococcus granulosus solute carrier family 22 0.0018 0.0181 0.0249
Mycobacterium ulcerans sugar transporter 0.0018 0.0181 0.0692
Plasmodium vivax glutathione reductase, putative 0.0048 0.0748 0.0739
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0586 0.4488
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0165 0.0698
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0181 0.0249
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0074 0.0102
Brugia malayi TAR-binding protein 0.0392 0.7271 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0577 0.0794
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0165 0.0857
Mycobacterium ulcerans beta-lactamase 0.0077 0.1295 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0562 0.1438
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0577 0.0794
Loa Loa (eye worm) beta-lactamase 0.0077 0.1295 0.1781
Schistosoma mansoni hypothetical protein 0.0126 0.2237 0.3077
Echinococcus multilocularis lamin 0.0054 0.0872 0.1199
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0165 0.2738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0181 0.0769
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0181 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Leishmania major hypothetical protein, conserved 0.0077 0.1295 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Echinococcus multilocularis lamin dm0 0.0054 0.0872 0.1199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0013
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1906 0.1952
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1295 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0009 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Schistosoma mansoni protein kinase 0.0039 0.0577 0.0794
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0165 0.0156
Giardia lamblia Hexose transporter 0.0018 0.0181 0.0576
Schistosoma mansoni sugar transporter 0.0018 0.0181 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0392 0.7271 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0489 0.9112 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2136 0.2209
Echinococcus multilocularis General substrate transporter 0.0108 0.1901 0.2614
Onchocerca volvulus 0.0017 0.0165 0.0857
Brugia malayi MH2 domain containing protein 0.0121 0.2129 0.2928
Echinococcus multilocularis solute carrier family 22 0.0018 0.0181 0.0249
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0577 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2237 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0577 0.0794
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0378 0.5459
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.052
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0181 0.0249
Echinococcus multilocularis musashi 0.0054 0.0872 0.1199
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0165 0.0227
Echinococcus granulosus cysteine protease 0.0009 0.0009 0.0013
Onchocerca volvulus 0.0018 0.0181 0.0986
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1295 0.1287
Leishmania major cathepsin L-like protease 0.0064 0.1065 0.7981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Loa Loa (eye worm) glutathione reductase 0.0048 0.0748 0.1029
Echinococcus multilocularis cysteine protease 0.0017 0.0165 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Onchocerca volvulus 0.0054 0.0872 0.6576
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0577 0.0569
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1295 0.1781
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0157 0.0498
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0157 0.1152
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0157 0.0148
Brugia malayi glutathione reductase 0.0048 0.0748 0.1029
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0562 0.0773
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1295 0.5771
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0157 0.0498
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Plasmodium vivax vivapain-2 0.0017 0.0165 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0165 0.1209
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1295 0.127
Plasmodium vivax vivapain-2 0.0017 0.0165 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0392 0.7271 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2136 0.2209
Schistosoma mansoni sugar transporter 0.0018 0.0181 0.0249
Plasmodium falciparum glutathione reductase 0.0017 0.0157 0.0148
Schistosoma mansoni glucose transporter 0.0018 0.0181 0.0249
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0562 0.0773
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0378 0.052
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0562 0.0773
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Plasmodium falciparum glutathione reductase 0.0048 0.0748 0.0739
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1906 0.1952
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1065 0.8214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0181 0.0692
Loa Loa (eye worm) sugar transporter 0.0018 0.0181 0.0249
Brugia malayi beta-lactamase family protein 0.0077 0.1295 0.1781
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0181 0.0249
Onchocerca volvulus 0.0018 0.0181 0.0986
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1295 0.5771
Plasmodium vivax hexose transporter 0.0126 0.2237 0.223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0157 0.1152
Loa Loa (eye worm) hypothetical protein 0.0053 0.0853 0.1173
Schistosoma mansoni sugar transporter 0.0018 0.0181 0.0249
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0586 0.4488
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Onchocerca volvulus 0.0017 0.0165 0.0857
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0165 0.0156
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1065 0.8214
Brugia malayi beta-lactamase 0.0077 0.1295 0.1781
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1295 0.1781
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0181 0.1333
Plasmodium falciparum hexose transporter 0.0126 0.2237 0.223
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.087 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Onchocerca volvulus 0.0017 0.0165 0.0857
Schistosoma mansoni lamin 0.0054 0.0872 0.1199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1295 0.127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0562 0.9739
Onchocerca volvulus Putative transporter 0.0018 0.0181 0.0986
Loa Loa (eye worm) hypothetical protein 0.0038 0.0562 0.0773
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2136 0.2209
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1906 0.1952
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.2237 0.3226
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0727 0.1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0727 0.1
Onchocerca volvulus 0.0018 0.0181 0.0986
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0378 0.1942
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1295 0.127
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0577 0.0569
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0157 0.0665
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0395 0.0543
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1906 0.1952
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0165 0.0227
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0378 0.052
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0157 0.0665
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0586 0.259
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.034 0.0468
Entamoeba histolytica cysteine protease, putative 0.0017 0.0165 0.2738
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0681 0.4604
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0577 0.0569
Echinococcus granulosus General substrate transporter 0.0108 0.1901 0.2614
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0157 0.0148
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0532 0.0731
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0586 0.4488
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Onchocerca volvulus 0.0018 0.0181 0.0986
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0165 0.0227
Echinococcus multilocularis solute carrier family 22 0.0018 0.0181 0.0249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0081
Onchocerca volvulus 0.0018 0.0181 0.0986
Leishmania major cathepsin L-like protease 0.0064 0.1065 0.7981
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0157 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0586 0.259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0157 0.0498
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0181 0.0769
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0157 0.2123
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0181 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0727 0.1
Loa Loa (eye worm) cysteine protease 0.0017 0.0165 0.0227
Echinococcus granulosus tumor protein p63 0.037 0.6853 0.9425
Mycobacterium ulcerans lipase LipD 0.0077 0.1295 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0577 0.0794
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0165 0.2738
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1295 1
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0378 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Brugia malayi Cathepsin L-like precursor 0.0011 0.0059 0.0081
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Schistosoma mansoni protein kinase 0.0039 0.0577 0.0794
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0395 0.0543
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0681 0.5225
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0378 0.052
Brugia malayi beta-lactamase family protein 0.0077 0.1295 0.1781
Onchocerca volvulus 0.0018 0.0181 0.0986
Trypanosoma brucei trypanothione reductase 0.0048 0.0748 0.5745
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Brugia malayi RNA recognition motif domain containing protein 0.0392 0.7271 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0392 0.7271 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0727 0.1
Onchocerca volvulus 0.0018 0.0181 0.0986
Leishmania major glucose transporter, lmgt2 0.0039 0.0586 0.3771
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0181 0.0172
Schistosoma mansoni intermediate filament proteins 0.0054 0.0872 0.1199
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Giardia lamblia Sugar-proton symporter 0.0018 0.0181 0.0576
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0165 0.0227
Toxoplasma gondii sugar transporter ST2 0.0018 0.0181 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Echinococcus granulosus solute carrier family 22 0.0018 0.0181 0.0249
Brugia malayi Cathepsin L-like precursor 0.0011 0.0059 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Mycobacterium tuberculosis Conserved protein 0.0077 0.1295 0.127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Brugia malayi major facilitator superfamily protein 0.0018 0.0181 0.0249
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0165 0.0227
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0748 0.5745
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0165 0.0857
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0157 0.1152
Echinococcus multilocularis solute carrier family 22 0.0018 0.0181 0.0249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1295 0.1781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Echinococcus granulosus solute carrier family 22 0.0018 0.0181 0.0249
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1295 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0298 0.0157
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Loa Loa (eye worm) hypothetical protein 0.0026 0.034 0.0468
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0181 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1295 0.5771
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0681 0.0672
Loa Loa (eye worm) fibroinase 0.0017 0.0165 0.0227
Echinococcus granulosus lamin dm0 0.0054 0.0872 0.1199
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0378 0.1656
Schistosoma mansoni peptidase 0.0009 0.0009 0.0013
Mycobacterium tuberculosis Probable reductase 0.0109 0.1906 0.1952
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0009 0.0013
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0577 0.0651
Schistosoma mansoni tar DNA-binding protein 0.0392 0.7271 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0727 0.1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0727 0.1
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0181 0.1333
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0165 0.0698
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0378 0.052
Schistosoma mansoni glucose transport protein 0.0126 0.2237 0.3077
Schistosoma mansoni sugar transporter 0.0018 0.0181 0.0249
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0157 0.0217
Echinococcus multilocularis cysteine protease 0.0017 0.0165 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1065 0.8214
Schistosoma mansoni glucose transport protein 0.0126 0.2237 0.3077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1295 0.127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0181 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0562 0.0773
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0165 0.0156
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0378 0.2343
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0562 0.2481
Onchocerca volvulus 0.0054 0.0872 0.6576
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0165 0.0857
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0586 0.4488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Echinococcus granulosus tar DNA binding protein 0.0392 0.7271 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0681 0.4604
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0586 0.259
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2237 0.3077
Trichomonas vaginalis esterase, putative 0.0077 0.1295 0.5771
Loa Loa (eye worm) hypothetical protein 0.0025 0.0321 0.0442
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Schistosoma mansoni protein kinase 0.0039 0.0577 0.0794
Echinococcus multilocularis tumor protein p63 0.037 0.6853 0.9425
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Brugia malayi cathepsin L-like precursor 0.0011 0.0059 0.0081
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0577 0.0651
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0157 0.0148
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0577 0.0569
Plasmodium vivax sugar transporter, putative 0.0018 0.0181 0.0172
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0577 0.0794
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0727 0.1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Leishmania major cathepsin L-like protease 0.0017 0.0165 0.0065
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0804 0.6181
Onchocerca volvulus 0.0017 0.0165 0.0857
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0727 0.1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0577 0.0794
Entamoeba histolytica hypothetical protein 0.0028 0.0378 0.6501
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0165 0.0227
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Mycobacterium tuberculosis Conserved protein 0.0077 0.1295 0.127
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0577 0.0569
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1295 0.5426
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0586 0.259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1295 0.127
Onchocerca volvulus 0.0017 0.0165 0.0857
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0577 0.0569
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0681 0.5225
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0681 0.5225
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1906 0.8748
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0181 0.1333
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0748 0.0739
Entamoeba histolytica protein kinase, putative 0.0039 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0586 0.3771
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0157 0.1152
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0872 0.1199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Leishmania major cathepsin L-like protease 0.0017 0.0165 0.0065
Onchocerca volvulus 0.0018 0.0181 0.0986
Trypanosoma brucei glucose transporter 1E 0.0039 0.0586 0.4488
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1295 0.1781
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2129 0.2928
Schistosoma mansoni tar DNA-binding protein 0.0392 0.7271 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3711 0.3705
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0181 0.0769
Onchocerca volvulus 0.0017 0.0165 0.0857
Echinococcus multilocularis solute carrier family 22 0.0018 0.0181 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Schistosoma mansoni glucose transport protein 0.0126 0.2237 0.3077
Leishmania major glucose transporter, lmgt3 0.0039 0.0586 0.3771
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.034 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0378 0.287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0586 0.259
Echinococcus granulosus solute carrier family 22 0.0018 0.0181 0.0249
Echinococcus multilocularis tar DNA binding protein 0.0392 0.7271 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0562 0.0773
Loa Loa (eye worm) hypothetical protein 0.0031 0.0428 0.0588
Brugia malayi Sugar transporter family protein 0.0018 0.0181 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0181 0.0026
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1295 0.127
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0009 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1295 0.1781
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0081
Brugia malayi Sugar transporter family protein 0.0018 0.0181 0.0249
Loa Loa (eye worm) TAR-binding protein 0.0392 0.7271 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0872 0.1199
Leishmania major glucose transporter, lmgt1 0.0039 0.0586 0.3771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Onchocerca volvulus 0.0018 0.0181 0.0986
Plasmodium falciparum thioredoxin reductase 0.0048 0.0748 0.0739
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0009 0.0013
Onchocerca volvulus 0.0018 0.0181 0.0986
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1295 0.5771
Schistosoma mansoni tar DNA-binding protein 0.0392 0.7271 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0378 0.0369
Echinococcus multilocularis cathepsin L 0.0009 0.0009 0.0013
Onchocerca volvulus 0.0077 0.1295 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0298 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0181 0.0769
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0681 0.0672
Brugia malayi major facilitator superfamily protein 0.0018 0.0181 0.0249
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0181 0.0249
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0181 0.1333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Plasmodium falciparum protein kinase 7 0.0357 0.6605 0.6602
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3711 0.3705
Brugia malayi hypothetical protein 0.0018 0.0181 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0059 0.0222
Mycobacterium leprae Probable lipase LipE 0.0077 0.1295 0.5426
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0181 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0586 0.259
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0181 0.0692
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0577 0.0794
Onchocerca volvulus 0.0077 0.1295 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1295 0.127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0059 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0059 0.0871
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0378 0.0438
Leishmania major protein kinase, putative 0.0039 0.0577 0.3688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0378 1
Onchocerca volvulus 0.0018 0.0181 0.0986
Toxoplasma gondii sugar transporter ST1 0.0018 0.0181 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1295 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0165 0.0227
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0313 0.1361
Brugia malayi hypothetical protein 0.0018 0.0181 0.0249
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0157 0.1152
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1065 0.8214
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0577 0.2548
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0249
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1906 0.1952
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2129 0.2928
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0165 0.0065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0748 0.1029
Brugia malayi intermediate filament protein 0.0054 0.0872 0.1199
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0378 0.0369
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0532 0.0731
Schistosoma mansoni lamin 0.0054 0.0872 0.1199
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0165 0.0227
Leishmania major cathepsin L-like protease 0.0017 0.0165 0.0065
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Trypanosoma brucei glucose transporter, putative 0.0039 0.0586 0.4488
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0181 0.0769
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0157 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1065 0.8214
Echinococcus granulosus lamin 0.0054 0.0872 0.1199
Loa Loa (eye worm) hypothetical protein 0.0054 0.087 0.1197
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0959 0.7389
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0157 0.0217
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Onchocerca volvulus 0.0018 0.0181 0.0986
Brugia malayi Cathepsin L-like precursor 0.0017 0.0165 0.0227
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0181 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1295 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0181 0.0769
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0165 0.0227
Echinococcus granulosus intermediate filament protein 0.0054 0.0872 0.1199
Leishmania major cathepsin L-like protease 0.0064 0.1065 0.7981
Echinococcus granulosus cathepsin L 0.0009 0.0009 0.0013
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0577 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Mycobacterium ulcerans hypothetical protein 0.0077 0.1295 1
Onchocerca volvulus 0.0017 0.0165 0.0857
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0157 0.1152
Entamoeba histolytica protein kinase, putative 0.0039 0.0577 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0748 0.0916
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0748 0.1029
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0577 0.0569
Loa Loa (eye worm) hypothetical protein 0.0077 0.1295 0.1781
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Plasmodium falciparum thioredoxin reductase 0.0017 0.0157 0.0148
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0157 0.1152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0165 0.0698
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0059 0.0081
Loa Loa (eye worm) ctsf protein 0.0017 0.0165 0.0227
Toxoplasma gondii sugar transporter ST3 0.0018 0.0181 0.0036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2136 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0181 0.0769
Onchocerca volvulus 0.0018 0.0181 0.0986

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 10 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 941 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) = 0.2495 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.2495 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.344 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.344 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 15 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) = 15 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) > 15 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) > 15 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
Growth Inhibition (functional) = 9.8332 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 904.2 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 3.0985193252563477 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 3.09851932525635 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 = 15.525004386901855 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) = 25.398416519165 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) = 25.39841651916504 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IFI promiscuity index = 0.0274 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Inhibition (functional) = -19.6307385526423 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -19.630738552642278 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -11.4178094007946 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -11.417809400794592 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -6.17667023428521 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 2 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 7 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 8.11 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 9.89240578974714 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 11.7 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 62.54514052 % MMV: NCI60 panel. Malaria Box compounds were tested for inhibition of the human Ovarian Cancer cell line NCI/ADR-RES ChEMBL. No reference
Inhibition (functional) = 72 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Percent growth inhibition (functional) = 88.9 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 101.1 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Ratio (functional) = 0.837209302325581 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -1.0114 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -1.002 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.6451 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 2 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783
Homo sapiens ChEMBL23
Trypanosoma cruzi ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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