Detailed information for compound 653005

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.376 | Formula: C21H17N3O6
  • H donors: 1 H acceptors: 4 LogP: 2.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCOc1cc(ccc1OC)C=C1C(=O)NC(=O)N(C1=O)c1ccc(cc1)OC
  • InChi: 1S/C21H17N3O6/c1-28-15-6-4-14(5-7-15)24-20(26)16(19(25)23-21(24)27)11-13-3-8-17(29-2)18(12-13)30-10-9-22/h3-8,11-12H,10H2,1-2H3,(H,23,25,27)/b16-11-
  • InChiKey: HDPYIVCBLDXQFZ-WJDWOHSUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0228 0.0225
Brugia malayi nuclear receptor RXR 0.003 0.0089 0.011
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0072 0.0089
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0228 0.0281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0518 0.0519
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0149 0.0149
Brugia malayi hypothetical protein 0.0085 0.0372 0.0459
Onchocerca volvulus 0.0131 0.0605 0.483
Brugia malayi hypothetical protein 0.003 0.0089 0.011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0089 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0168 0.0794 0.0989
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0228 0.0281
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0061 0.0246 0.0303
Brugia malayi follicle stimulating hormone receptor 0.0347 0.1715 0.2117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0122 0.0143
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0051 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0935 0.0941
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.0935 0.1164
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0007 0.0008
Echinococcus granulosus Polycystic kidney disease protein 0.0029 0.0082 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0935 0.0941
Echinococcus multilocularis RUN 0.0029 0.0082 0.0076
Brugia malayi Importin beta-1 subunit 0.0031 0.0094 0.0116
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0129 0.0152
Schistosoma mansoni coup transcription factor 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0228 0.1104 0.1375
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0063 0.0029
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.056 0.4439
Loa Loa (eye worm) TK/ABL protein kinase 0.0442 0.2203 0.2744
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0149 0.0175
Entamoeba histolytica hypothetical protein 0.0025 0.0063 0.0015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.1647 0.2052
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0072 0.0067
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0149 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0228 0.0281
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0041 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Echinococcus granulosus dna polymerase kappa 0.0042 0.0149 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0387 0.1923 0.2373
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0149 0.0183
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0072 0.0089
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0228 0.0284
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0149 0.0149
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0149 0.0185
Brugia malayi nuclear receptor NHR-67 0.0027 0.0072 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Loa Loa (eye worm) heterochromatin protein 1 0.0052 0.0203 0.0252
Echinococcus granulosus lamin dm0 0.0084 0.0364 0.0442
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0092 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0228 0.0281
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0122 0.0151
Schistosoma mansoni hypothetical protein 0.1077 0.5467 0.6746
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0041 0.005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0149 0.0135
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0149 0.0183
Brugia malayi beta-lactamase family protein 0.0036 0.0117 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0498 0.2495 0.3078
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0228 0.0284
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Brugia malayi MH2 domain containing protein 0.0101 0.0451 0.0557
Echinococcus multilocularis snurportin 1 0.0334 0.1647 0.1665
Echinococcus granulosus tar DNA binding protein 0.0387 0.1923 0.2367
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.159 0.8104 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0089 0.011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0347 0.1715 0.2136
Schistosoma mansoni smad 0.0101 0.0451 0.0557
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0519 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0063 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0185
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0072 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0334 0.1647 0.2033
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.159 0.8104 1
Brugia malayi latrophilin 2 splice variant baaae 0.1077 0.5467 0.6746
Loa Loa (eye worm) hypothetical protein 0.0122 0.056 0.0697
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0364 0.0454
Brugia malayi steroid hormone receptor 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0935 0.1153
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0122 0.0102
Onchocerca volvulus 0.0131 0.0609 0.4865
Schistosoma mansoni rab6-interacting 0.0029 0.0082 0.0101
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0084 0.0364 0.0454
Onchocerca volvulus 0.0038 0.0129 0.0679
Brugia malayi MH1 domain containing protein 0.0056 0.022 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Toxoplasma gondii ABC1 family protein 0.0036 0.0117 0.0145
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0165 0.016
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0228 0.0284
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0117 0.0145
Schistosoma mansoni hypothetical protein 0.0549 0.2755 0.34
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0129 0.0152
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.129 0.129
Plasmodium vivax SET domain protein, putative 0.0031 0.0092 0.0114
Schistosoma mansoni sodium/solute symporter 0.0038 0.0129 0.016
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0063
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0295
Echinococcus multilocularis lamin dm0 0.0084 0.0364 0.0363
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.159 0.8104 1
Onchocerca volvulus 0.0084 0.0364 0.2732
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Brugia malayi N-terminal motif family protein 0.0228 0.1104 0.1362
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0072 0.0081
Schistosoma mansoni ran 0.0023 0.0051 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0498 0.2495 0.3078
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0264 0.129 0.129
Echinococcus multilocularis lipoxygenase domain containing protein 0.0029 0.0082 0.0076
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0129 0.0152
Schistosoma mansoni glycosyltransferase-related 0.0047 0.0173 0.0213
Echinococcus granulosus geminin 0.0549 0.2755 0.3394
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0072 0.0089
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0101 0.0451 0.0451
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0061 0.0246 0.0303
Brugia malayi conserved hypotetical protein 0.0027 0.0072 0.0089
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0303
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0122 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0072 0.0067
Trypanosoma brucei unspecified product 0.0042 0.0149 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.1575 0.8028 0.9907
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0228 0.0274
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0129 0.0125
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.129 0.129
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0098 0.0121
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1197 0.1434
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0061 0.0246 0.0303
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1071 0.5438 0.6773
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0129 0.0125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.111 0.4267
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0072 0.0081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0228 0.0225
Echinococcus granulosus importin subunit beta 1 0.0031 0.0094 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0089 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0203 0.0202
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0051
Echinococcus granulosus mothers against decapentaplegic 5 0.0101 0.0451 0.0549
Brugia malayi MH2 domain containing protein 0.0045 0.0165 0.0203
Echinococcus multilocularis peptidase Clp (S14 family) 0.004 0.0138 0.0133
Brugia malayi beta-lactamase 0.0036 0.0117 0.0145
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0149 0.0149
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0032 0.0098 0.0121
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0228 0.0281
Echinococcus granulosus chromobox protein 1 0.0052 0.0203 0.0242
Brugia malayi Isocitrate dehydrogenase 0.0264 0.129 0.1591
Schistosoma mansoni tyrosine kinase 0.0014 0.0007 0.0008
Echinococcus multilocularis Polycystic kidney disease protein 0.0029 0.0082 0.0076
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.159 0.8104 1
Loa Loa (eye worm) nuclear factor I 0.0056 0.022 0.0273
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.159 0.8104 0.8104
Plasmodium falciparum importin beta, putative 0.0031 0.0094 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0023 0.0052 0.0064
Loa Loa (eye worm) doublecortin family protein 0.0029 0.0082 0.0102
Loa Loa (eye worm) hypothetical protein 0.0132 0.0613 0.0764
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0228 0.1104 0.9189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0228 0.0281
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0364 0.045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0072 0.0081
Leishmania major DNA polymerase eta, putative 0.0042 0.0149 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0228 0.0225
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0117 0.0112
Plasmodium falciparum LCCL domain-containing protein 0.0029 0.0082 0.0101
Entamoeba histolytica hypothetical protein 0.0114 0.0518 0.058
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1923 0.2373
Schistosoma mansoni hypothetical protein 0.0114 0.0518 0.064
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0122 0.0122
Echinococcus granulosus RUN 0.0029 0.0082 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.129 0.1302
Schistosoma mansoni lamin 0.0084 0.0364 0.045
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0072 0.0089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.159 0.8104 0.8104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0082 0.0102
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.5136 0.6397
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0072 0.0067
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0228 0.0281
Entamoeba histolytica hypothetical protein 0.0114 0.0518 0.058
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.1959 1 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.159 0.8104 1
Echinococcus granulosus Smad4 0.0101 0.0451 0.0549
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0303
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 1
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0228 0.0274
Loa Loa (eye worm) transcription factor SMAD2 0.1479 0.7534 0.9385
Onchocerca volvulus 0.0029 0.0082 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0498 0.2495 0.2524
Brugia malayi MH1 domain containing protein 0.0101 0.0451 0.0557
Schistosoma mansoni chromobox protein 0.0052 0.0203 0.025
Brugia malayi nuclear receptor NHR-88 0.0057 0.0228 0.0281
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0117 0.0096
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0122 0.0151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0117 0.0145
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0092 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0092 0.0114
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0141 0.0166
Echinococcus granulosus tyrosine protein kinase ABL1 0.0442 0.2203 0.2712
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0032 0.0098 0.0072
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0122 0.0117
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0122 0.0088
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0149 0.0149
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0228 0.0281
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0442 0.2203 0.2228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0518 0.0632
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0051 0.0063
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0122 0.0102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0185
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.159 0.8104 0.8104
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0228 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0549 0.2755 0.34
Brugia malayi hypothetical protein 0.0029 0.0082 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0117 0.0117
Onchocerca volvulus 0.0036 0.0117 0.0575
Brugia malayi isocitrate dehydrogenase 0.0264 0.129 0.1591
Onchocerca volvulus 0.0057 0.0228 0.1541
Echinococcus multilocularis G protein coupled receptor 139 0.018 0.0858 0.0864
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0105
Brugia malayi hypothetical protein 0.0029 0.0082 0.0101
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0051
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0096 0.0385
Brugia malayi MH2 domain containing protein 0.0101 0.0451 0.0557
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0032 0.0098 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0498 0.2495 0.3107
Schistosoma mansoni unc-13 (munc13) 0.0032 0.0098 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0149 0.0149
Echinococcus granulosus chromobox protein 1 0.0052 0.0203 0.0242
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.159 0.8104 1
Loa Loa (eye worm) DR-78 0.0027 0.0072 0.009
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0032 0.0098 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0082 0.0102
Brugia malayi Cytochrome P450 family protein 0.0026 0.0069 0.0085
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0069 0.0069
Brugia malayi hypothetical protein 0.0131 0.0609 0.0751
Entamoeba histolytica hypothetical protein 0.0114 0.0518 0.058
Echinococcus granulosus survival motor neuron protein 1 0.0531 0.2664 0.3282
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0117 0.0082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0228 0.0274
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0117 0.0082
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0069 0.0086
Brugia malayi Cytochrome P450 family protein 0.0026 0.0069 0.0085
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0089 0.0102
Leishmania major GTP-binding protein, putative 0.0023 0.0051 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0935 0.1146
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1013 0.5136 0.6397
Echinococcus granulosus peptidase Clp S14 family 0.004 0.0138 0.0162
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0102 0.0253
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0264 0.129 0.5024
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0051
Brugia malayi SRC-1 0.0014 0.0007 0.0008
Loa Loa (eye worm) RNA binding protein 0.0387 0.1923 0.2395
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0228 0.0274
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0082
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0072 0.0081
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0264 0.129 0.1591
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0045 0.0165 0.0161
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1071 0.5438 0.6773
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0069 0.0085
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.5136 0.632
Brugia malayi Pax transcription factor protein 2 0.0131 0.0605 0.0746
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0354 0.1752 0.177
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0063
Trypanosoma brucei unspecified product 0.0029 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0228 0.0281
Schistosoma mansoni hypothetical protein 0.0029 0.0082 0.0101
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.049 0.0605
Loa Loa (eye worm) hypothetical protein 0.0094 0.0418 0.0521
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0069 0.0069
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0364 0.0454
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0494 0.247 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 0.8104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0117 0.0145
Echinococcus multilocularis tyrosine protein kinase Abl 0.018 0.0858 0.0864
Echinococcus multilocularis Glycosyl transferase, family 8 0.0047 0.0173 0.0168
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0166
Echinococcus multilocularis survival motor neuron protein 1 0.0531 0.2664 0.2696
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.129 0.1302
Brugia malayi Inositol-1 0.0037 0.0122 0.0151
Onchocerca volvulus 0.0084 0.0364 0.2732
Schistosoma mansoni DNA polymerase eta 0.0042 0.0149 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0084 0.0055
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0122 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0036 0.0117 0.0117
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0101 0.0451 0.0557
Loa Loa (eye worm) beta-lactamase 0.0036 0.0117 0.0146
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0032 0.0098 0.0121
Schistosoma mansoni lipoxygenase 0.0173 0.0823 0.1015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0122 0.0122
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0117 0.0082
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 0.8104
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0164 0.0203
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0165 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Plasmodium vivax ataxin-2 like protein, putative 0.0132 0.0613 0.0757
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.0613 0.0757
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0228 0.0281
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0149 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.0823 0.1008
Schistosoma mansoni tyrosine kinase 0.0435 0.217 0.2678
Schistosoma mansoni lipoxygenase 0.0121 0.0555 0.0685
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0129 0.0125
Schistosoma mansoni isocitrate dehydrogenase 0.0032 0.0098 0.0121
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0072 0.009
Loa Loa (eye worm) hypothetical protein 0.0094 0.0418 0.0521
Brugia malayi intermediate filament protein 0.0084 0.0364 0.045
Toxoplasma gondii isocitrate dehydrogenase 0.0264 0.129 0.1591
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Schistosoma mansoni tyrosine kinase 0.0014 0.0007 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0117 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0084 0.0055
Brugia malayi hypothetical protein 0.0114 0.0518 0.064
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1923 0.2373
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0243
Loa Loa (eye worm) isocitrate dehydrogenase 0.0264 0.129 0.1606
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0096
Brugia malayi nuclear receptor RXR 0.0027 0.0072 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Echinococcus multilocularis smad 0.0101 0.0451 0.0451
Schistosoma mansoni rab6-interacting 0.0029 0.0082 0.0101
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0092 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.1479 0.7534 0.9385
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0082
Schistosoma mansoni smad1 5 8 and 0.0101 0.0451 0.0557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0935 0.1146
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0264 0.129 0.1591
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0032 0.0098 0.0235
Echinococcus granulosus high affinity choline transporter 1 0.0346 0.1711 0.2106
Echinococcus multilocularis dna polymerase eta 0.0042 0.0149 0.0144
Loa Loa (eye worm) pax transcription factor protein 2 0.0131 0.0605 0.0753
Toxoplasma gondii isocitrate dehydrogenase 0.0264 0.129 0.1591
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Mycobacterium leprae Probable lipase LipE 0.0036 0.0117 0.0315
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.159 0.8104 1
Entamoeba histolytica tartrate dehydrogenase, putative 0.0032 0.0098 0.0058
Brugia malayi hypothetical protein 0.0027 0.0072 0.0089
Loa Loa (eye worm) hypothetical protein 0.0498 0.2495 0.3107
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0038 0.0129 0.0161
Loa Loa (eye worm) hypothetical protein 0.0061 0.0246 0.0306
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0072 0.0067
Brugia malayi nuclear hormone receptor 0.0027 0.0072 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0228 0.0281
Schistosoma mansoni nuclear receptor 0.0027 0.0072 0.0089
Brugia malayi hypothetical protein 0.0122 0.056 0.0691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0228 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1923 0.2373
Brugia malayi chromobox protein homolog 3 0.0029 0.0084 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0096
Brugia malayi MH1 domain containing protein 0.0056 0.022 0.0271
Onchocerca volvulus 0.0036 0.0117 0.0575
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0264 0.129 0.1585
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0072 0.0089
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.159 0.8104 0.8104
Brugia malayi beta-lactamase family protein 0.0036 0.0117 0.0145
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0098 0.0121
Leishmania major cytochrome p450-like protein 0.0026 0.0069 0.0069
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0035 0.0111 0.0106
Mycobacterium ulcerans beta-lactamase 0.0036 0.0117 0.0145
Loa Loa (eye worm) inositol-1 0.0037 0.0122 0.0152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0051 0.0055
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.159 0.8104 0.8214
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0498 0.2495 0.2524
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.004 0.0138 0.0169
Schistosoma mansoni lamin 0.0084 0.0364 0.045
Plasmodium vivax multidomain scavenger receptor, putative 0.0029 0.0082 0.0101
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0164 0.0204
Schistosoma mansoni inositol transporter 0.0038 0.0129 0.016
Brugia malayi MH1 domain containing protein 0.0101 0.0451 0.0557
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0032 0.0098 0.0121
Echinococcus granulosus neuropeptide receptor 0.018 0.0858 0.1052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0117 0.0145
Leishmania major DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0165 0.016
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0072 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0228 0.0284
Trichomonas vaginalis esterase, putative 0.0036 0.0117 0.0096
Brugia malayi Pre-SET motif family protein 0.0216 0.1043 0.1288
Loa Loa (eye worm) hypothetical protein 0.1013 0.5136 0.6397
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0264 0.129 0.1302
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1013 0.5136 0.632
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0032 0.0098 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.0935 0.1153
Schistosoma mansoni inositol transporter 0.0038 0.0129 0.016
Schistosoma mansoni importin beta-1 0.0031 0.0094 0.0116
Schistosoma mansoni hypothetical protein 0.0498 0.2495 0.3078
Echinococcus multilocularis isocitrate dehydrogenase 0.0264 0.129 0.1302
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0072 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0136 0.0168
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.0823 0.0828
Echinococcus multilocularis lamin 0.0084 0.0364 0.0363
Loa Loa (eye worm) hypothetical protein 0.0346 0.1711 0.2132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0228 0.0284
Schistosoma mansoni high-affinity choline transporter 0.0346 0.1711 0.2112
Brugia malayi nuclear hormone receptor 0.0057 0.0228 0.0281
Schistosoma mansoni smad 0.0045 0.0165 0.0203
Onchocerca volvulus Huntingtin homolog 0.0122 0.056 0.4439
Schistosoma mansoni hypothetical protein 0.0498 0.2495 0.3078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1575 0.8028 0.9907
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.159 0.8104 0.8104
Echinococcus granulosus GPCR family 2 0.0498 0.2495 0.3073
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0519 0.2599 0.3208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0228 0.0284
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0203 0.0202
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0519 0.2599 0.2599
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0061 0.0246 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0228 0.0281
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.159 0.8104 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0061 0.0246 0.0844
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0072 0.0181
Trypanosoma brucei unspecified product 0.0029 0.0082 0.0082
Brugia malayi RNA binding protein 0.0387 0.1923 0.2373
Schistosoma mansoni neuropeptide receptor 0.018 0.0858 0.1059
Echinococcus multilocularis GPCR, family 2 0.0498 0.2495 0.2524
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0000016905 0.0000021056
Schistosoma mansoni ran 0.0023 0.0051 0.0063
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0228 0.0281
Brugia malayi Steroid receptor seven-up type 2 0.0354 0.1752 0.2161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0228 0.0225
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0051 0.0063
Loa Loa (eye worm) hypothetical protein 0.0327 0.1612 0.2008
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0096 0.0069
Onchocerca volvulus 0.0027 0.0072 0.0181
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0451 0.0562
Loa Loa (eye worm) MH1 domain-containing protein 0.0101 0.0451 0.0562
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1043 0.13
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0094 0.0116
Trypanosoma brucei PAB1-binding protein , putative 0.0132 0.0613 0.0613
Brugia malayi hypothetical protein 0.0132 0.0613 0.0757
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0032 0.0098 0.0121
Brugia malayi ecdysone receptor 0.0027 0.0072 0.0089
Echinococcus granulosus lipoxygenase domain containing protein 0.0029 0.0082 0.0093
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0264 0.129 0.129
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0117 0.0096
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0037
Brugia malayi hypothetical protein 0.0531 0.2664 0.3287
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0228 0.0274
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0072 0.0089
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0228 0.1541
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0518 0.064
Mycobacterium ulcerans lipase LipD 0.0036 0.0117 0.0145
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0117 0.0315
Trichomonas vaginalis chromobox protein, putative 0.0032 0.0096 0.0069
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 0.8104
Leishmania major importin beta-1 subunit, putative 0.0025 0.0063 0.0063
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0072 0.0089
Schistosoma mansoni inositol monophosphatase 0.0037 0.0122 0.0151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0149 0.0214
Schistosoma mansoni hypothetical protein 0.0498 0.2495 0.3078
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0165 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0935 0.1153
Schistosoma mansoni survival motor neuron protein 0.0108 0.049 0.0605
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0228 0.0281
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0117 0.0082
Loa Loa (eye worm) hypothetical protein 0.0122 0.056 0.0697
Schistosoma mansoni smad1 5 8 and 0.0101 0.0451 0.0557
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0264 0.129 0.129
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0029 0.0084 0.0285
Loa Loa (eye worm) SRC-1 0.0014 0.0007 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0072 0.0081
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0122 0.0102
Trichomonas vaginalis ran, putative 0.0023 0.0051 0.0014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.004 0.0138 0.04
Plasmodium vivax importin-beta 2, putative 0.0031 0.0094 0.0116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0356 0.0444
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.159 0.8104 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0089 0.011
Loa Loa (eye worm) hypothetical protein 0.1077 0.5467 0.681
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0045 0.0165 0.0161
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.5136 0.5204
Brugia malayi Glycosyl transferase family 8 protein 0.0047 0.0173 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0354 0.1752 0.2155
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0228 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Schistosoma mansoni polycystin 1-related 0.0029 0.0082 0.0101
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0072 0.0181
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.159 0.8104 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.004 0.0138 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0117 0.0145
Brugia malayi RasGEF domain containing protein 0.0013 0.0000016905 0.0000020861
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0087 0.0099
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.159 0.8104 0.8214
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0129 0.016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1933 0.9864 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0101 0.0451 0.0549
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0117 0.0146
Toxoplasma gondii hypothetical protein 0.0021 0.0041 0.005
Loa Loa (eye worm) nuclear hormone receptor 0.0324 0.1596 0.1988
Onchocerca volvulus 0.004 0.0136 0.0742
Echinococcus multilocularis conserved hypothetical protein 0.0035 0.0111 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0228 0.0225
Brugia malayi hypothetical protein 0.003 0.0089 0.011
Echinococcus multilocularis chromobox protein 1 0.0052 0.0203 0.0199
Schistosoma mansoni loxhd1 0.0029 0.0082 0.0101
Loa Loa (eye worm) hypothetical protein 0.0056 0.022 0.0273
Echinococcus multilocularis geminin 0.0549 0.2755 0.2788
Echinococcus multilocularis solute carrier family 5 0.0038 0.0129 0.0125
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.159 0.8104 0.8104
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0228 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1923 0.2373
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.159 0.8104 0.8104
Brugia malayi Tyrosine-protein kinase abl-1 0.018 0.0858 0.1059
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0165 0.0195
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0082
Schistosoma mansoni chromobox protein 0.0052 0.0203 0.025
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1013 0.5136 0.6335
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0387 0.1923 0.2395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0228 0.0284
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0238 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0228 0.0274
Schistosoma mansoni tyrosine kinase 0.0014 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0165 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0072 0.0089
Brugia malayi Heterochromatin protein 1 0.0052 0.0203 0.025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0228 0.0281
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0089 0.0084
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0149 0.0144
Schistosoma mansoni Smad4 0.0045 0.0165 0.0203
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0035 0.0111 0.0129
Echinococcus granulosus smad 0.0101 0.0451 0.0549
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0032 0.0098 0.0093
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0228 0.1541
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0089 0.011
Entamoeba histolytica hypothetical protein 0.0114 0.0518 0.058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Leishmania major isocitrate dehydrogenase, putative 0.0032 0.0098 0.0098
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0032 0.0098 0.0113
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0094 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0117 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0092 0.0114
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0578 0.2901 0.358
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0149 0.0183
Echinococcus multilocularis lipoxygenase domain containing protein 0.0029 0.0082 0.0076
Mycobacterium ulcerans hypothetical protein 0.0036 0.0117 0.0145
Echinococcus granulosus lipoxygenase domain containing protein 0.0029 0.0082 0.0093
Schistosoma mansoni Smad4 0.0045 0.0165 0.0203
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0063
Giardia lamblia DINP protein human, muc B family 0.0042 0.0149 0.0183
Onchocerca volvulus 0.0027 0.0072 0.0181
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0149 0.0183
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.159 0.8104 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0117
Loa Loa (eye worm) hypothetical protein 0.1575 0.8028 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0228 0.0281
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0117 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.009
Schistosoma mansoni smad1 5 8 and 0.0101 0.0451 0.0557
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0117 0.0096
Echinococcus granulosus snurportin 1 0.0334 0.1647 0.2026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0498 0.2495 0.3073
Brugia malayi TAR-binding protein 0.0387 0.1923 0.2373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0498 0.2495 0.3073
Leishmania major hypothetical protein, conserved 0.0132 0.0613 0.0613
Echinococcus multilocularis chromobox protein 1 0.0052 0.0203 0.0199
Brugia malayi Smad1 0.0101 0.0451 0.0557
Loa Loa (eye worm) Smad1 0.0101 0.0451 0.0562
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.159 0.8104 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0149 0.0149
Brugia malayi hypothetical protein 0.0027 0.0072 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0228 0.0284
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0122
Echinococcus granulosus dna polymerase eta 0.0042 0.0149 0.0175
Brugia malayi nuclear receptor NHR-88 0.0027 0.0072 0.0089
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0072 0.009
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1096 0.5567 0.687
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0072 0.0089
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0045 0.0165 0.0161
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.1959 1 1
Schistosoma mansoni zinc finger protein 0.0027 0.0072 0.0089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0519 0.2599 0.2599
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0149 0.0214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Schistosoma mansoni hypothetical protein 0.0059 0.0238 0.0294
Echinococcus multilocularis musashi 0.0084 0.0364 0.0363
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0228 0.0281
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0045 0.0165 0.0196
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0228 0.0225
Brugia malayi Doublecortin family protein 0.0029 0.0082 0.0101
Brugia malayi ecdysteroid receptor 0.0057 0.0228 0.0281
Loa Loa (eye worm) hypothetical protein 0.0013 0.0000016905 0.0000021056
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0094 0.0094
Echinococcus multilocularis tar DNA binding protein 0.0387 0.1923 0.1944
Echinococcus multilocularis high affinity choline transporter 1 0.0346 0.1711 0.173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1575 0.8028 1
Echinococcus granulosus intermediate filament protein 0.0084 0.0364 0.0442
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 0.8104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0129 0.0152
Brugia malayi N-terminal motif family protein 0.0013 0.0000016905 0.0000020861
Brugia malayi Probable ClpP-like protease 0.0061 0.0246 0.0303
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0146
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.159 0.8104 1
Schistosoma mansoni tar DNA-binding protein 0.0387 0.1923 0.2373
Onchocerca volvulus 0.0246 0.1197 1
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0228 0.0274
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0578 0.2901 0.3548
Schistosoma mansoni hypothetical protein 0.0108 0.049 0.0605
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0063 0.0029
Echinococcus granulosus lamin 0.0084 0.0364 0.0442
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.159 0.8104 1
Loa Loa (eye worm) hypothetical protein 0.0531 0.2664 0.3318
Brugia malayi photoreceptor-specific nuclear receptor 0.0363 0.18 0.2222
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0102 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0132 0.0613 0.0757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0935 0.1153
Brugia malayi RNA, U transporter 1 0.0089 0.039 0.0481
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0047 0.0173 0.0215
Schistosoma mansoni inositol monophosphatase 0.0037 0.0122 0.0151
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.159 0.8104 1
Loa Loa (eye worm) TAR-binding protein 0.0387 0.1923 0.2395
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0165 0.0205
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0264 0.129 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0228 0.0281
Brugia malayi GH02984p 0.0346 0.1711 0.2112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0092 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0069 0.0086
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.159 0.8104 1
Onchocerca volvulus 0.0108 0.049 0.383
Loa Loa (eye worm) hypothetical protein 0.0057 0.0228 0.0284
Brugia malayi hypothetical protein 0.0094 0.0418 0.0516
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0228 0.0281
Plasmodium falciparum ataxin-2 like protein, putative 0.0132 0.0613 0.0757
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0117 0.0082
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0519 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.003 0.0089 0.0111
Echinococcus multilocularis neuropeptide receptor 0.018 0.0858 0.0864
Echinococcus granulosus solute carrier family 5 0.0038 0.0129 0.0152
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0494 0.247 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0072 0.0081
Schistosoma mansoni hypothetical protein 0.0498 0.2495 0.3078
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.159 0.8104 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.159 0.8104 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0264 0.129 0.1302
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0165 0.0203
Schistosoma mansoni Smad4 0.0101 0.0451 0.0557
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0165 0.0987
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0228 0.0225
Schistosoma mansoni intermediate filament proteins 0.0084 0.0364 0.045
Loa Loa (eye worm) hypothetical protein 0.0363 0.18 0.2243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0228 0.1541
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0082 0.0082
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.159 0.8104 0.8104
Onchocerca volvulus 0.0036 0.0117 0.0575
Echinococcus granulosus Glycosyl transferase family 8 0.0047 0.0173 0.0205
Brugia malayi MH2 domain containing protein 0.1479 0.7534 0.9297
Brugia malayi Pre-SET motif family protein 0.0031 0.0092 0.0114
Onchocerca volvulus 0.0029 0.0082 0.0264
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0149 0.0135
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.1959 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0092 0.0114
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0519 0.2599 0.2599
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0117 0.0137
Brugia malayi tailless protein 0.0027 0.0072 0.0089
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0149 0.0183
Trypanosoma cruzi PAB1-binding protein , putative 0.0132 0.0613 0.0613
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.159 0.8104 1
Schistosoma mansoni nuclear receptor 0.0027 0.0072 0.0089
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0072 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0228 0.0225
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0117 0.0082
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.159 0.8104 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0101 0.0451 0.0451
Schistosoma mansoni peptidase Clp (S14 family) 0.0061 0.0246 0.0303
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0032 0.0098 0.0122
Schistosoma mansoni tyrosine kinase 0.0014 0.0007 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0238 0.0286
Schistosoma mansoni eyes absent homolog 0.0094 0.0418 0.0516
Mycobacterium tuberculosis Conserved protein 0.0036 0.0117 0.0082
Loa Loa (eye worm) hypothetical protein 0.0131 0.0609 0.0758
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0129 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0069 0.0086
Brugia malayi Tyrosine-protein kinase abl-1 0.0268 0.1309 0.1615
Echinococcus multilocularis Smad4 0.0101 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0031 0.0092 0.0115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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