Detailed information for compound 657308

Basic information

Technical information
  • TDR Targets ID: 657308
  • Name: 2-[2-bromo-6-ethoxy-4-[(3-oxo-1-benzothiophen -2-ylidene)methyl]phenoxy]acetic acid
  • MW: 435.288 | Formula: C19H15BrO5S
  • H donors: 1 H acceptors: 3 LogP: 4.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(cc(c1OCC(=O)O)Br)C=C1Sc2c(C1=O)cccc2
  • InChi: 1S/C19H15BrO5S/c1-2-24-14-8-11(7-13(20)19(14)25-10-17(21)22)9-16-18(23)12-5-3-4-6-15(12)26-16/h3-9H,2,10H2,1H3,(H,21,22)/b16-9-
  • InChiKey: YAJBDYJTEMAQBU-SXGWCWSVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-bromo-6-ethoxy-4-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(3-oxobenzothiophen-2-ylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(Z)-(3-oxobenzothiophen-2-ylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(Z)-(3-oxo-2-benzothiophenylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(3-oxo-2-benzothiophenylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(3-ketobenzothiophen-2-ylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(Z)-(3-ketobenzothiophen-2-ylidene)methyl]phenoxy]acetic acid
  • 2-[2-bromo-6-ethoxy-4-[(3-oxo-1-benzothiophen-2-ylidene)methyl]phenoxy]ethanoic acid
  • 2-[2-bromo-6-ethoxy-4-[(Z)-(3-oxo-1-benzothiophen-2-ylidene)methyl]phenoxy]ethanoic acid
  • ChemDiv1_006392
  • BAS 02830262
  • [2-Bromo-6-ethoxy-4-(3-oxo-3H-benzo[b]thiophen-2-ylidenemethyl)-phenoxy]-acetic

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dishevelled segment polarity protein 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Segment polarity protein dishevelled homolog DVL-1, putative Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum ko:K02353 dishevelled, putative Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma mansoni dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Onchocerca volvulus Segment polarity protein dishevelled homolog Get druggable targets OG5_130104 All targets in OG5_130104
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum Segment polarity protein dishevelled homolog DVL-1, putative Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus granulosus segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus multilocularis segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus multilocularis segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus granulosus segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma mansoni dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum expressed protein Get druggable targets OG5_130104 All targets in OG5_130104
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Echinococcus multilocularis expressed conserved protein 0.0182 0.0157 0.0157
Mycobacterium ulcerans AcrR family transcriptional regulator 0.286 0.2617 1
Trichomonas vaginalis ferritin, putative 0.0018 0.0007 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0014 0.0401
Echinococcus multilocularis tumor protein p63 0.286 0.2617 0.2617
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0087 0.0333
Echinococcus multilocularis musashi 0.0028 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0386 0.0344 1
Echinococcus multilocularis lamin 0.0028 0.0016 0.0016
Toxoplasma gondii patched family protein 0.0012 0.0001 0.0021
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0021 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0193
Echinococcus granulosus cpg binding protein 0.0032 0.0019 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0036 0.0036
Echinococcus granulosus cysteine protease 0.0026 0.0014 0.0014
Echinococcus multilocularis Niemann Pick C1 protein 0.0276 0.0244 0.0244
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.008 0.0063 0.024
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0202 0.0176 0.0672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.008 0.0063 0.2138
Echinococcus granulosus neuropeptide s receptor 0.0486 0.0437 0.0437
Brugia malayi intermediate filament protein 0.0028 0.0016 0.0088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0271 0.0239 0.0912
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0091 0.1001
Echinococcus multilocularis dnaJ subfamily B 0.043 0.0385 0.0385
Onchocerca volvulus Protein patched homolog 0.0012 0.0001 0.0007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0005 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0005 0.0193
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0036 0.0202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0053 0.0053
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0007 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0016 0.0088
Plasmodium vivax unspecified product 0.0017 0.0005 0.0177
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0003
Brugia malayi hypothetical protein 0.0012 0.0001 0.0003
Echinococcus multilocularis expressed protein 0.0018 0.0007 0.0007
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0014 0.0469
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0012 0.0423
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0091 0.0349
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0001 0.0001
Trichomonas vaginalis set domain proteins, putative 0.1006 0.0914 1
Loa Loa (eye worm) hypothetical protein 0.0419 0.0374 0.2078
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0271 0.0239 0.0912
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0063 0.024
Leishmania major pantothenate kinase subunit, putative 0.0015 0.0003 0.0143
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.008 0.0063 0.024
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0032 0.1103
Echinococcus granulosus cathepsin L 0.0026 0.0014 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.01 0.0558
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0074
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0402 0.0359 0.1995
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.008 0.0063 0.024
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0036 0.1235
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0331 0.0294 0.0294
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0003 0.0003
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0007
Schistosoma mansoni lamin 0.0028 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0014 0.0826
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Brugia malayi beta-lactamase family protein 0.0111 0.0091 0.0508
Onchocerca volvulus 0.0051 0.0036 0.0398
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0193
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0107 0.3631
Schistosoma mansoni dishevelled 0.0104 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0217 0.0189 0.0723
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0021 0.0021
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0016 0.0669
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0091 0.0091
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Schistosoma mansoni dishevelled 0.0116 0.0097 0.0097
Entamoeba histolytica acyl-coA synthetase, putative 0.0271 0.0239 0.6931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0036 0.0036
Echinococcus granulosus survival motor neuron protein 1 0.1972 0.1801 0.1801
Brugia malayi AMP-binding enzyme family protein 0.008 0.0063 0.0349
Mycobacterium ulcerans acyl-CoA synthetase 0.0271 0.0239 0.0912
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.0437 0.0437
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.008 0.0063 0.024
Loa Loa (eye worm) hypothetical protein 0.0271 0.0239 0.1325
Mycobacterium ulcerans lipase LipD 0.0111 0.0091 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0271 0.0239 0.0912
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0016 0.0543
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0091 0.0349
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0271 0.0239 0.6931
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0107 0.0107
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.008 0.0063 0.0349
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.0167 0.0167
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0063 0.024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.008 0.0063 0.3767
Brugia malayi beta-lactamase family protein 0.0111 0.0091 0.0508
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0007 0.0025
Echinococcus multilocularis segment polarity protein dishevelled 0.0116 0.0097 0.0097
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0083 0.0066 0.0367
Onchocerca volvulus 0.0012 0.0001 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0191 0.0166 0.0633
Brugia malayi Myosin head containing protein 0.0012 0.0001 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0047 0.1587
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.0167 1
Onchocerca volvulus 0.0051 0.0036 0.0398
Brugia malayi Patched related family protein 4 0.0012 0.0001 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.008 0.0063 0.0688
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0276
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0091 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0271 0.0239 0.0912
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0016 0.0464
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0036 0.0036
Brugia malayi hypothetical protein 0.0016 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) glutathione reductase 0.0046 0.0032 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Brugia malayi CHE-14 protein 0.0083 0.0066 0.0367
Brugia malayi protein C24B5.3 0.0012 0.0001 0.0003
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0014 0.0826
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0007 0.0007
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.008 0.0063 0.1827
Loa Loa (eye worm) hypothetical protein 0.0271 0.0239 0.1325
Onchocerca volvulus 0.0028 0.0016 0.0174
Echinococcus granulosus tumor protein p63 0.286 0.2617 0.2617
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0007 0.0222
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0001 0.0001
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0007 0.0025
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0001 0.0037
Brugia malayi hypothetical protein 0.1972 0.1801 1
Toxoplasma gondii patched family protein 0.0012 0.0001 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0107 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0012 0.0423
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0006
Brugia malayi Flap endonuclease-1 0.0028 0.0016 0.0089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0007 0.0026
Toxoplasma gondii hypothetical protein 0.0114 0.0095 0.3219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0331 0.0294 0.1633
Brugia malayi AMP-binding enzyme family protein 0.0271 0.0239 0.1325
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0012 0.0423
Loa Loa (eye worm) hypothetical protein 0.0056 0.0041 0.0229
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0116 0.0097 0.0537
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0069
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0114 0.0095 0.0362
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0025 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0001 0.0001
Onchocerca volvulus 0.0051 0.0036 0.0398
Echinococcus granulosus ferritin 0.0018 0.0007 0.0007
Schistosoma mansoni microtubule-associated protein tau 1.0898 1 1
Brugia malayi Thioredoxin reductase 0.0046 0.0032 0.018
Toxoplasma gondii ABC1 family protein 0.0111 0.0091 0.3109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0271 0.0239 0.0912
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0331 0.0294 0.0294
Echinococcus multilocularis cysteine protease 0.0051 0.0036 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0005 0.0276
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0007 0.0025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0063 0.024
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.0167 0.0167
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0063 0.024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Schistosoma mansoni hypothetical protein 0.043 0.0385 0.0385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Schistosoma mansoni patched 1 0.0083 0.0066 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0036 0.2176
Plasmodium vivax SET domain protein, putative 0.0127 0.0107 0.3631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0041 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus granulosus expressed conserved protein 0.0182 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0007 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0091 0.0508
Schistosoma mansoni hypothetical protein 0.008 0.0063 0.0063
Toxoplasma gondii propionate-CoA ligase 0.008 0.0063 0.2138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0091 0.0349
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0014 0.0401
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0087 0.0333
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.286 0.2617 1
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.008 0.0063 0.024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0041 0.0229
Onchocerca volvulus 0.0012 0.0001 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.0419 0.0374 0.0374
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0003 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0012 0.0745
Schistosoma mansoni acetyl-CoA synthetase 0.008 0.0063 0.0063
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0114 0.0095 0.3219
Plasmodium vivax vivapain-1 0.0026 0.0014 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Mycobacterium leprae Probable lipase LipE 0.0111 0.0091 0.0349
Toxoplasma gondii exonuclease III APE 0.0018 0.0007 0.0231
Brugia malayi Niemann-Pick C1 protein precursor 0.0193 0.0167 0.0929
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0386 0.0344 0.0344
Leishmania major 4-coumarate:coa ligase-like protein 0.0271 0.0239 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.008 0.0063 0.3767
Brugia malayi MH2 domain containing protein 0.012 0.01 0.0558
Onchocerca volvulus 0.008 0.0063 0.0688
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Conserved protein 0.0111 0.0091 0.0349
Leishmania major 4-coumarate:coa ligase-like protein 0.0271 0.0239 1
Echinococcus granulosus flap endonuclease 1 0.0028 0.0016 0.0016
Mycobacterium ulcerans transcriptional regulator 0.286 0.2617 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0884 0.0802 0.4451
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0217 0.0189 0.0723
Loa Loa (eye worm) hypothetical protein 0.0202 0.0176 0.0976
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0271 0.0239 0.0912
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0091 0.0091
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0007 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Leishmania major cathepsin L-like protease 0.0193 0.0167 0.6996
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Brugia malayi AMP-binding enzyme family protein 0.008 0.0063 0.0349
Echinococcus multilocularis protein patched 0.0083 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0386 0.0344 1
Onchocerca volvulus 0.0111 0.0091 0.1001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0176 0.0152 0.908
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0036 0.1235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Schistosoma mansoni transcription factor LCR-F1 0.0386 0.0344 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Onchocerca volvulus 0.008 0.0063 0.0688
Echinococcus multilocularis microtubule associated protein 2 1.0898 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0036 0.0202
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0331 0.0294 1
Toxoplasma gondii patched family protein 0.0012 0.0001 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0021 0.0609
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0014 0.0401
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0005 0.289
Loa Loa (eye worm) hypothetical protein 0.0271 0.0239 0.1325
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Plasmodium vivax patched family protein, putative 0.0012 0.0001 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0021 0.0229
Echinococcus multilocularis survival motor neuron protein 1 0.1972 0.1801 0.1801
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0087 0.0333
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0006
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.008 0.0063 0.3767
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0116
Plasmodium vivax unspecified product 0.0026 0.0014 0.0469
Onchocerca volvulus 0.008 0.0063 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Brugia malayi Pre-SET motif family protein 0.0884 0.0802 0.4451
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.008 0.0063 0.0063
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus multilocularis lamin dm0 0.0028 0.0016 0.0016
Onchocerca volvulus 0.1006 0.0914 1
Loa Loa (eye worm) DIX domain-containing protein 0.0023 0.0011 0.006
Trypanosoma cruzi cruzipain precursor, putative 0.0193 0.0167 1
Schistosoma mansoni ferritin light chain 0.0018 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0193 0.0167 0.6996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0036 0.0036
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0005 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0006 0.0034
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0007 0.0066
Onchocerca volvulus 0.0012 0.0001 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0407
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0003
Brugia malayi DIX domain containing protein 0.0023 0.0011 0.006
Brugia malayi Patched related family protein 12 0.0012 0.0001 0.0003
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.008 0.0063 0.2138
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0087 0.0333
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0007 0.0197
Brugia malayi beta-lactamase 0.0111 0.0091 0.0508
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0029
Toxoplasma gondii cathepsin CPL 0.0051 0.0036 0.1235
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0029
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0036 0.0202
Leishmania major cathepsin L-like protease 0.0051 0.0036 0.1522
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.008 0.0063 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Onchocerca volvulus 0.0012 0.0001 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0191 0.0166 0.0633
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0202 0.0176 0.591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Echinococcus granulosus peptidase Clp S14 family 0.0217 0.0189 0.0189
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0036 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0006 0.0006
Schistosoma mansoni peptidase Clp (S14 family) 0.0331 0.0294 0.0294
Onchocerca volvulus 0.0402 0.0359 0.3932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0021 0.0229
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0014 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0091 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0014 0.0014
Brugia malayi Patched protein homolog 1 0.0012 0.0001 0.0003
Leishmania major cathepsin L-like protease 0.0051 0.0036 0.1522
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0015 0.0003 0.0205
Plasmodium vivax vivapain-2 0.0051 0.0036 0.1235
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0032 0.0124
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0271 0.0239 0.0912
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0005 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0407
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0005 0.0157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0034
Plasmodium falciparum thioredoxin reductase 0.0046 0.0032 0.1103
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0005 0.0276
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2383 0.2179 0.2179
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0036 0.0202
Echinococcus multilocularis geminin 0.0178 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Schistosoma mansoni lamin 0.0028 0.0016 0.0016
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.008 0.0063 0.024
Onchocerca volvulus 0.0051 0.0036 0.0398
Echinococcus granulosus cathepsin l1 0.0051 0.0036 0.0036
Mycobacterium tuberculosis Probable reductase 0.0106 0.0087 0.0333
Brugia malayi hypothetical protein 0.0012 0.0001 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0312
Brugia malayi CXXC zinc finger family protein 0.003 0.0018 0.0098
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0012 0.0423
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0006 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0016 0.0088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium ulcerans acetyl-CoA synthetase 0.008 0.0063 0.024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0098 0.0374
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0001 0.0001
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.008 0.0063 0.024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0707 0.0639 0.2442
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.0167 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0005 0.005
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0091 0.0349
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0007 0.0075
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0007 0.0025
Onchocerca volvulus 0.0127 0.0107 0.1169
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0088
Mycobacterium tuberculosis Conserved protein 0.0111 0.0091 0.0349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0063 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0098 0.0374
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Leishmania major cathepsin L-like protease 0.0051 0.0036 0.1522
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0066 0.0051 0.0557
Onchocerca volvulus 0.0012 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Entamoeba histolytica hypothetical protein 0.0386 0.0344 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0005 0.0157
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.008 0.0063 0.0349
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0007 0.0038
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0271 0.0239 0.6931
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.008 0.0063 0.024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0098 0.0374
Loa Loa (eye worm) oxidoreductase 0.008 0.0063 0.0349
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0001 0.0004
Echinococcus granulosus dnaJ subfamily B 0.043 0.0385 0.0385
Echinococcus granulosus lamin dm0 0.0028 0.0016 0.0016
Onchocerca volvulus 0.0271 0.0239 0.2611
Echinococcus granulosus lamin 0.0028 0.0016 0.0016
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0107 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0107 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0006 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0041 0.0229
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 0.1124
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0016 0.0175
Brugia malayi Probable ClpP-like protease 0.0331 0.0294 0.1633
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.008 0.0063 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.01 0.0558
Trypanosoma brucei trypanothione reductase 0.0046 0.0032 0.1944
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0016 1
Toxoplasma gondii hypothetical protein 0.0012 0.0001 0.0021
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0003 0.0015
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.008 0.0063 0.024
Onchocerca volvulus 0.0111 0.0091 0.1001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0271 0.0239 1
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0036 0.1055
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.008 0.0063 0.3767
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0005 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0107 0.0107
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0016 0.0956
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0271 0.0239 0.1325
Onchocerca volvulus Protein patched homolog 0.0012 0.0001 0.0007
Entamoeba histolytica hypothetical protein 0.0386 0.0344 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0331 0.0294 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0032 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0014 0.0826
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0063 0.0349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0191 0.0166 0.0633
Leishmania major cathepsin L-like protease 0.0193 0.0167 0.6996
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0462
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0007 0.0285
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0386 0.0344 0.0344
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0196 0.017 0.017
Leishmania major trypanothione reductase 0.0046 0.0032 0.136
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0036 0.1235
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0063 0.0349
Brugia malayi acetyl-Coenzyme A synthetase 2 0.008 0.0063 0.0349
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0066 0.0367
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.008 0.0063 0.024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Mycobacterium ulcerans hypothetical protein 0.0271 0.0239 0.0912
Schistosoma mansoni ferritin 0.0018 0.0007 0.0007
Trypanosoma brucei acetyl-CoA synthetase, putative 0.008 0.0063 0.3767
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0016 0.0956
Onchocerca volvulus 0.0051 0.0036 0.0398
Brugia malayi hypothetical protein 0.0025 0.0012 0.0069
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) cysteine protease 0.0051 0.0036 0.0202
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0116
Schistosoma mansoni hypothetical protein 0.008 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0091 0.3109
Echinococcus granulosus intermediate filament protein 0.0028 0.0016 0.0016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0091 0.0349
Echinococcus multilocularis segment polarity protein dishevelled 0.0116 0.0097 0.0097
Schistosoma mansoni cpg binding protein 0.003 0.0018 0.0018
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.008 0.0063 0.2636
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Echinococcus multilocularis cathepsin L 0.0026 0.0014 0.0014
Toxoplasma gondii thioredoxin reductase 0.0046 0.0032 0.1103
Onchocerca volvulus 0.0028 0.0016 0.0174
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.008 0.0063 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Treponema pallidum NADH oxidase 0.0016 0.0005 0.0157
Onchocerca volvulus 0.003 0.0018 0.0192
Schistosoma mansoni survival motor neuron protein 0.0402 0.0359 0.0359
Onchocerca volvulus 0.0034 0.0021 0.0229
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0003
Echinococcus granulosus segment polarity protein dishevelled 0.0116 0.0097 0.0097
Echinococcus granulosus segment polarity protein dishevelled 0.0116 0.0097 0.0097
Brugia malayi hypothetical protein 0.0012 0.0001 0.0006
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0014 0.0826
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0091 0.0349
Brugia malayi glutathione reductase 0.0046 0.0032 0.018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0193 0.0167 0.4861
Schistosoma mansoni hypothetical protein 0.008 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0036 0.0398
Echinococcus multilocularis ferritin 0.0018 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0091 0.1001
Onchocerca volvulus 0.0051 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0029
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0091 0.0349
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Leishmania major acetyl-CoA synthetase, putative 0.008 0.0063 0.2636
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0005 0.0312
Plasmodium vivax acetyl-CoA synthetase, putative 0.008 0.0063 0.2138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0013
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Echinococcus multilocularis cysteine protease 0.0051 0.0036 0.0036
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0001 0.0001
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Brugia malayi Cathepsin L-like precursor 0.0051 0.0036 0.0202
Leishmania major cathepsin L-like protease 0.0051 0.0036 0.1522
Loa Loa (eye worm) ctsf protein 0.0051 0.0036 0.0202
Brugia malayi cathepsin L-like precursor 0.0034 0.0021 0.0116
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0001 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.0202 0.0176 0.5974
Mycobacterium tuberculosis Conserved protein 0.0111 0.0091 0.0349
Loa Loa (eye worm) hypothetical protein 0.0202 0.0176 0.0976
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0036 0.0398
Echinococcus multilocularis cpg binding protein 0.0032 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0191 0.0166 0.0633
Brugia malayi protein C24B5.3 0.0012 0.0001 0.0003
Brugia malayi Cathepsin L-like precursor 0.0034 0.0021 0.0116
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.008 0.0063 0.3767
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0007 0.4257
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0098 0.0374
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0016 0.0016
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0114 0.0095 0.3219
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0005 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0005 0.0276
Onchocerca volvulus 0.0419 0.0374 0.4097
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0087 0.0333
Loa Loa (eye worm) hypothetical protein 0.0116 0.0097 0.0537
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 1
Mycobacterium ulcerans hypothetical protein 0.0111 0.0091 0.0349
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0032 0.1944
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Schistosoma mansoni hypothetical protein 0.0178 0.0154 0.0154
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0007 0.0231
Plasmodium falciparum glutathione reductase 0.0046 0.0032 0.1103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0007 0.0026
Onchocerca volvulus 0.0111 0.0091 0.1001
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0012 0.0745
Schistosoma mansoni hypothetical protein 0.008 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0178 0.0154 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Schistosoma mansoni flap endonuclease-1 0.0026 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0127 0.0107 0.0593
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0063 0.024
Onchocerca volvulus 0.008 0.0063 0.0688
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0091 0.5478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0005 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0012 0.0745
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0005 0.0276
Onchocerca volvulus 0.0051 0.0036 0.0398
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0091 0.5478
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.0167 1
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0036 0.0398
Toxoplasma gondii hypothetical protein 0.0012 0.0001 0.0037
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0007
Echinococcus multilocularis peptidase Clp (S14 family) 0.0217 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0386 0.0344 0.0344
Brugia malayi hypothetical protein 0.0012 0.0001 0.0003
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0001 0.0037
Plasmodium falciparum acetyl-CoA synthetase, putative 0.008 0.0063 0.2138
Schistosoma mansoni intermediate filament proteins 0.0028 0.0016 0.0016
Brugia malayi AMP-binding enzyme family protein 0.008 0.0063 0.0349
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0129 0.773
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0014 0.0401
Echinococcus granulosus expressed protein 0.0018 0.0007 0.0007
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0091 0.0091
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0066 0.0723
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0014 0.0401
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0014 0.0826
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0005 0.0157
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0107 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0271 0.0239 0.0912
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0014 0.0077
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0063 0.024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0202 0.0176 0.0672
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0005 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Trichomonas vaginalis antibiotic synthetase, putative 0.008 0.0063 0.0688
Loa Loa (eye worm) fibroinase 0.0051 0.0036 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0091 0.5478
Leishmania major acetyl-CoA synthetase, putative 0.008 0.0063 0.2636
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0016 0.0543
Trichomonas vaginalis esterase, putative 0.0111 0.0091 0.1001
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.0437 0.0437
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0091 0.1001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0006 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0014 0.0401
Mycobacterium ulcerans beta-lactamase 0.0111 0.0091 0.0349
Plasmodium falciparum flap endonuclease 1 0.0028 0.0016 0.0543
Plasmodium vivax acyl-CoA synthetase, putative 0.0202 0.0176 0.5974
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Plasmodium vivax vivapain-2 0.0051 0.0036 0.1235
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0001 0.0001
Toxoplasma gondii patched family protein 0.0012 0.0001 0.0021
Plasmodium vivax glutathione reductase, putative 0.0046 0.0032 0.1103
Loa Loa (eye worm) beta-lactamase 0.0111 0.0091 0.0508
Loa Loa (eye worm) hypothetical protein 0.0111 0.0091 0.0508
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0005 0.0026
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0036 0.1522
Leishmania major cathepsin L-like protease 0.0051 0.0036 0.1522
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.0437 0.0437
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0016 0.0088
Echinococcus granulosus cathepsin l1 0.0034 0.0021 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0271 0.0239 0.0912
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.008 0.0063 0.024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0091 0.0349
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0091 0.1001
Brugia malayi Cathepsin L-like precursor 0.0034 0.0021 0.0116
Echinococcus multilocularis GPCR, family 2 0.0018 0.0006 0.0006
Schistosoma mansoni apoferritin-2 0.0018 0.0007 0.0007
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0202 0.0176 0.0976
Schistosoma mansoni hypothetical protein 0.0018 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0051 0.0036 0.1055
Mycobacterium ulcerans TetR family transcriptional regulator 0.286 0.2617 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Onchocerca volvulus 0.0012 0.0001 0.0007
Brugia malayi Patched related family protein 10 0.0012 0.0001 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0005 0.0276
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0091 0.1001
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0091 0.0508
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0331 0.0294 0.1124
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0331 0.0294 0.1124
Loa Loa (eye worm) patched family protein 0.0012 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0036 0.0398
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0005 0.0193
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0193 0.0167 0.0929
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.0167 1
Brugia malayi hypothetical protein 0.0012 0.0001 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0005 0.0157
Loa Loa (eye worm) hypothetical protein 0.0127 0.0107 0.0593
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0068 0.0053 0.0202
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0007 0.0407
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0018 0.0098
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0001 0.0004
Echinococcus granulosus geminin 0.0178 0.0154 0.0154
Onchocerca volvulus 0.0012 0.0001 0.0007
Schistosoma mansoni cathepsin s 0.0017 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0001 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0271 0.0239 0.1325
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0114 0.0095 0.3219
Brugia malayi hypothetical protein 0.0012 0.0001 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.0231
Entamoeba histolytica cysteine protease, putative 0.0026 0.0014 0.0401
Echinococcus granulosus GPCR family 2 0.0018 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0014 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0014 0.0151
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.0231
Loa Loa (eye worm) hypothetical protein 0.0202 0.0176 0.0976
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0019
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0217 0.0189 0.0723
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0032 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0005 0.0276
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0036 0.1055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0036 0.0398
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0087 0.0333
Loa Loa (eye worm) hypothetical protein 0.008 0.0063 0.0349
Echinococcus multilocularis protein dispatched 1 0.0095 0.0077 0.0077
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0331 0.0294 1
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0063 0.024
Brugia malayi hypothetical protein 0.0386 0.0344 0.1912
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.008 0.0063 0.024
Echinococcus granulosus Niemann Pick C1 protein 0.0276 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0402 0.0359 0.0359
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.286 0.2617 1
Leishmania major hypothetical protein, conserved 0.0111 0.0091 0.3832
Brugia malayi AMP-binding enzyme family protein 0.008 0.0063 0.0349
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0005 0.0157
Plasmodium falciparum glutathione reductase 0.0016 0.0005 0.0157
Leishmania major hypothetical protein, conserved 0.0025 0.0012 0.0521
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0122 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0014 0.0151
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0019
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.1972 0.1801 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0271 0.0239 0.0912
Brugia malayi Patched family protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0091 0.0349
Loa Loa (eye worm) hypothetical protein 0.0202 0.0176 0.0976
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0036 0.0036
Plasmodium vivax vivapain-3 0.0026 0.0014 0.0469
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0036 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0014 0.0077
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0032 0.0032
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0016 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0014 0.0826

Activities

Activity type Activity value Assay description Source Reference
Ka (binding) = 5.12 10'4/M/s Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as association rate by SPR analysis ChEMBL. 27112452
Kd (binding) = 5.75 10'-1/s Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate by SPR analysis ChEMBL. 27112452
Kd (binding) = 0.186 uM Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by fluorescence spectroscopy ChEMBL. 27112452
Kd (binding) = 11.2 uM Binding affinity to His-tagged Dvl-1 PDZ domain (247 to 337 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis ChEMBL. 27112452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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