Detailed information for compound 68046

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 599.634 | Formula: C32H33N5O7
  • H donors: 4 H acceptors: 5 LogP: 3 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Oc1ccc(cc1)CNc1nc(=O)n(cc1C)C[C@H](NC(=O)OCc1ccccc1)CC(=O)O)NCc1ccccc1
  • InChi: 1S/C32H33N5O7/c1-22-19-37(20-26(16-28(38)39)35-32(42)43-21-25-10-6-3-7-11-25)30(40)36-29(22)33-17-24-12-14-27(15-13-24)44-31(41)34-18-23-8-4-2-5-9-23/h2-15,19,26H,16-18,20-21H2,1H3,(H,34,41)(H,35,42)(H,38,39)(H,33,36,40)/t26-/m1/s1
  • InChiKey: WAJOPBHKWAECQH-AREMUKBSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0399 0.0799
Onchocerca volvulus 0.0021 0.0058 0.0341
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.0213
Mycobacterium tuberculosis Conserved protein 0.0079 0.0391 0.0373
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0058 0.1472
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Mycobacterium leprae Probable lipase LipE 0.0079 0.0391 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Echinococcus multilocularis dna polymerase eta 0.0021 0.0058 0.0056
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0547 0.3095 0.8764
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Brugia malayi Kelch motif family protein 0.0057 0.0267 0.0923
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0054 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0058 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0054 0.017
Giardia lamblia NADPH oxidoreductase, putative 0.008 0.0397 0.2082
Schistosoma mansoni hypothetical protein 0.0074 0.0363 0.0716
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0013 0.001 0.0268
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0054 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0054 0.0098
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0084 0.0083
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0351 0.1218
Brugia malayi mbt repeat family protein 0.0055 0.0254 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0145 0.0916
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0351 0.1077
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Loa Loa (eye worm) hypothetical protein 0.0054 0.0246 0.0678
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Toxoplasma gondii thioredoxin reductase 0.0042 0.0178 0.3371
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0058 0.0146
Onchocerca volvulus 0.0021 0.0058 0.0341
Schistosoma mansoni lamin 0.0053 0.0242 0.0472
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0298 0.0313
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0058 0.1013
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0232 0.5919
Onchocerca volvulus 0.0021 0.0058 0.0341
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0274 0.6908
Loa Loa (eye worm) Ulp1 protease 0.0013 0.001 0.0012
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0058 0.0105
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0127 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0138 0.026
Schistosoma mansoni hypothetical protein 0.0041 0.0172 0.0328
Brugia malayi Importin beta-1 subunit 0.0059 0.0274 0.0945
Brugia malayi hypothetical protein 0.0033 0.0127 0.0426
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.001 0.0087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.017 0.049
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0145 0.0125
Echinococcus multilocularis lamin dm0 0.0053 0.0242 0.0254
Leishmania major pyruvate kinase 0.0036 0.0145 0.3696
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.1488
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0232 0.5807
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.068 0.1369
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0066 0.146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.0487 0.0469
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Mycobacterium ulcerans recombinase A 0.0106 0.0547 0.1716
Trypanosoma brucei metacaspase 5, putative 0.0027 0.009 0.2075
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0124 0.2979
Echinococcus multilocularis integrin beta 2 0.028 0.1553 0.1661
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.01 0.0332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0316 0.0964
Echinococcus granulosus expressed conserved protein 0.0135 0.0717 0.1444
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0254 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0138 0.0374
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Onchocerca volvulus 0.0079 0.0391 0.2547
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Onchocerca volvulus 0.0021 0.0054 0.0318
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0054 0.0089
Leishmania major DNA polymerase eta, putative 0.0021 0.0058 0.1488
Onchocerca volvulus 0.008 0.0399 0.2599
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0242 0.0835
Echinococcus granulosus dna polymerase eta 0.0021 0.0058 0.0106
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1742
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0058 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0138 0.026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0058 0.0278
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0194
Giardia lamblia Pyruvate kinase 0.0036 0.0145 0.0738
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0291 0.057
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0506 0.1016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0298 0.0584
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0391 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0054 0.0052
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0391 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0058 0.0056
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0058 0.0124
Schistosoma mansoni intermediate filament proteins 0.0053 0.0242 0.0472
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0145 0.0738
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0054 0.0052
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0051 0.0239
Loa Loa (eye worm) hypothetical protein 0.0059 0.0274 0.0756
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0066 0.1179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.1885 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0408 0.2289 0.8061
Schistosoma mansoni hypothetical protein 0.0129 0.068 0.1362
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.002 0.0499
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0037
Loa Loa (eye worm) hypothetical protein 0.0129 0.068 0.1906
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0184 0.661
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.002 0.0256
Schistosoma mansoni hypothetical protein 0.0865 0.4929 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.017 0.4192
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.002 0.0265
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0043 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.017 0.0176
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0058 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.002 0.0256
Onchocerca volvulus 0.0053 0.0242 0.1563
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.002 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Loa Loa (eye worm) hypothetical protein 0.0503 0.2837 0.8005
Onchocerca volvulus 0.0055 0.0254 0.1638
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Mycobacterium ulcerans hypothetical protein 0.0072 0.0351 0.1077
Schistosoma mansoni survival motor neuron protein 0.0103 0.0528 0.1051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0316 0.0964
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.017 0.4347
Echinococcus multilocularis snurportin 1 0.0625 0.3543 0.38
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0148 0.0792 0.4167
Onchocerca volvulus Huntingtin homolog 0.0119 0.0622 0.4072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0054 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0066 0.1036
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0058 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0232 0.0638
Loa Loa (eye worm) hypothetical protein 0.0054 0.0246 0.0678
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.002 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0178 0.4537
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.009 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0054 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0229 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1043 0.1114
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0054 0.0098
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0118
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0184 0.4711
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0058 0.0182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.021 0.1084
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Mycobacterium ulcerans hypothetical protein 0.01 0.0515 0.1611
Echinococcus granulosus caspase 8 0.0027 0.009 0.017
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0012
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0391 0.0373
Brugia malayi Pre-SET motif family protein 0.0035 0.0138 0.0467
Trypanosoma brucei unspecified product 0.0021 0.0058 0.1254
Trypanosoma brucei trypanothione reductase 0.0042 0.0178 0.4386
Leishmania major importin beta-1 subunit, putative 0.0047 0.021 0.5358
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0391 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0351 0.8963
Toxoplasma gondii exonuclease III APE 0.0041 0.017 0.3225
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0254 0.07
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.0487 0.0469
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.008 0.0397 0.2082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.009 0.2287
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0399 0.0422
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0058 0.1488
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.01 0.0511 0.0542
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0058 0.1488
Mycobacterium ulcerans beta-lactamase 0.0079 0.0391 0.1209
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.0511 0.1017
Schistosoma mansoni pyruvate kinase 0.0036 0.0145 0.0273
Leishmania major pyruvate kinase 0.0036 0.0145 0.3696
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0058 0.0274
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0145 0.0916
Brugia malayi mbt repeat family protein 0.0055 0.0254 0.0875
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.002 0.0051 0.0216
Echinococcus granulosus integrin beta 2 0.028 0.1553 0.3142
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0316 0.063
Schistosoma mansoni patched 1 0.0042 0.0181 0.0346
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0291 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0351 0.1077
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0145 0.049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.002 0.0499
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0058 0.0124
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0054 0.0098
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0013 0.001 0.0268
Onchocerca volvulus Huntingtin homolog 0.0119 0.0622 0.4072
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.0361
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0066 0.146
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0054 0.0089
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0391 0.0373
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0058 0.0096
Loa Loa (eye worm) glutathione reductase 0.0042 0.0178 0.0485
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0145 0.049
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0351 0.1077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0229 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0351 0.8963
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0058 0.0182
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0054 0.0089
Echinococcus granulosus importin subunit beta 1 0.0059 0.0274 0.0544
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0351 0.8963
Schistosoma mansoni DNA polymerase eta 0.0021 0.0058 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.1488
Echinococcus multilocularis caspase 8 0.0027 0.009 0.009
Echinococcus granulosus caspase 2 0.0027 0.009 0.017
Onchocerca volvulus 0.0021 0.0058 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.017 0.0852
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0058 0.1237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0246 0.0678
Echinococcus multilocularis sentrin specific protease 8 0.0013 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0041 0.0172 0.0328
Echinococcus granulosus expressed conserved protein 0.0093 0.0472 0.0946
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0043 0.0853
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0058 0.0126
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0066 0.0151
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0012
Echinococcus granulosus lamin dm0 0.0053 0.0242 0.048
Echinococcus multilocularis sentrin specific protease 1 0.0013 0.001 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0058 0.0038
Schistosoma mansoni lamin 0.0053 0.0242 0.0472
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.017 0.0333
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.001 0.0016
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0399 0.079
Echinococcus multilocularis expressed conserved protein 0.0135 0.0717 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Brugia malayi beta-lactamase family protein 0.0079 0.0391 0.1361
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0391 0.1209
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0316 0.8074
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0066 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0229 0.021
Giardia lamblia DINP protein human, muc B family 0.0021 0.0058 0.0278
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0351 0.0846
Brugia malayi ecdysteroid receptor 0.0021 0.0054 0.017
Schistosoma mansoni hypothetical protein 0.0103 0.0528 0.1051
Echinococcus granulosus caspase 0.01 0.0511 0.1026
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0178 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0054 0.017
Mycobacterium leprae Conserved hypothetical protein 0.0622 0.3523 1
Schistosoma mansoni hypothetical protein 0.0343 0.1917 0.3876
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0138 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0357
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0058 0.0097
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.068 0.1369
Schistosoma mansoni ap endonuclease 0.0041 0.017 0.0325
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.009 0.164
Echinococcus granulosus pyruvate kinase 0.0036 0.0145 0.0282
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0066 0.0024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.0549 0.0531
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0181 0.0354
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.002 0.0051 0.0239
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0316 0.0621
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0084 0.0158
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0242 0.0668
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0316 0.6092
Plasmodium vivax metacaspase 1, putative 0.0027 0.009 0.2075
Echinococcus granulosus tar DNA binding protein 0.0061 0.0291 0.0578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1043 0.2106
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.009 0.2287
Echinococcus multilocularis lamin 0.0053 0.0242 0.0254
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.1885 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0351 0.0846
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0391 0.0373
Plasmodium falciparum glutathione reductase 0.0015 0.002 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0054 0.017
Giardia lamblia Pyruvate kinase 0.0019 0.0043 0.0196
Echinococcus granulosus GPCR family 2 0.0129 0.068 0.1369
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1043 0.2931
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.068 0.0724
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0058 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0054 0.017
Giardia lamblia Fructose-bisphosphate aldolase 0.0338 0.1885 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1043 0.2099
Leishmania major DNA polymerase kappa, putative 0.0021 0.0058 0.1488
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0054 0.0318
Loa Loa (eye worm) hypothetical protein 0.0099 0.0506 0.1414
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0058 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0054 0.017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0505 0.2847 0.2833
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0058 0.1472
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0058 0.1472
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0528 0.1842
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.009 0.164
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0058 0.1254
Trypanosoma brucei unspecified product 0.0015 0.002 0.0256
Echinococcus granulosus dnaJ subfamily B 0.0397 0.2227 0.4512
Onchocerca volvulus 0.0053 0.0242 0.1563
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0138 0.0269
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1638 0.9389 0.9387
Trichomonas vaginalis esterase, putative 0.0079 0.0391 0.2051
Trichomonas vaginalis Sentrin-specific protease, putative 0.0013 0.001 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0054 0.0052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0248 0.4751
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1625 0.9315 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0291 0.0804
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Echinococcus multilocularis caspase 3 0.0073 0.0357 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0054 0.0098
Onchocerca volvulus 0.0013 0.001 0.0029
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Giardia lamblia NADPH oxidoreductase, putative 0.008 0.0397 0.2082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0054 0.0098
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.017 0.058
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0138 0.2599
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0181 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0506 0.1766
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0351 0.1077
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.001 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.002
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0246 0.8946
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0351 0.0332
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0058 0.0148
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0515 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.0487 0.124
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0124 0.3167
Brugia malayi MH2 domain containing protein 0.0116 0.0605 0.2114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.1488
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0058 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0138 0.026
Loa Loa (eye worm) hypothetical protein 0.0072 0.0351 0.0975
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0291 0.0804
Echinococcus granulosus lamin 0.0053 0.0242 0.048
Brugia malayi hypothetical protein 0.0074 0.0363 0.126
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0066 0.1688
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Echinococcus granulosus pyruvate kinase 0.0036 0.0145 0.0282
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.001 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0051
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0058 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0316 0.0297
Trypanosoma brucei metacaspase MCA3 0.0027 0.009 0.2075
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0145 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0291 0.057
Echinococcus multilocularis survival motor neuron protein 1 0.0503 0.2837 0.3042
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.009 0.0161
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0351 0.0332
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.008 0.0397 0.2082
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0054 0.0136
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.001 0.0087
Loa Loa (eye worm) hypothetical protein 0.0063 0.0298 0.0825
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1742
Loa Loa (eye worm) beta-lactamase 0.0079 0.0391 0.109
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.017 0.6068
Echinococcus multilocularis caspase 2 0.0027 0.009 0.009
Loa Loa (eye worm) RNA binding protein 0.0061 0.0291 0.0804
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0232 0.4434
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Entamoeba histolytica hypothetical protein 0.0047 0.021 0.1063
Brugia malayi hypothetical protein 0.0119 0.0622 0.2176
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.002 0.0238
Entamoeba histolytica hypothetical protein 0.0074 0.0363 0.1879
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.002 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0351 0.1816
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0054 0.017
Plasmodium vivax glutathione reductase, putative 0.0042 0.0178 0.4386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.021 0.1084
Chlamydia trachomatis pyruvate kinase 0.0036 0.0145 0.25
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0054 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0279 0.1544 0.5432
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0058 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1043 0.2106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0351 0.1816
Entamoeba histolytica hypothetical protein 0.0074 0.0363 0.1879
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0232 0.5807
Echinococcus multilocularis cpg binding protein 0.0029 0.0106 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.1254
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0043 0.1235
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0888 0.087
Entamoeba histolytica Ran family GTPase 0.0043 0.0184 0.0928
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0058 0.1237
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0254 0.0495
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0291 0.1005
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0232 0.8407
Echinococcus granulosus geminin 0.0865 0.4929 1
Echinococcus granulosus dna polymerase kappa 0.0021 0.0058 0.0106
Brugia malayi Thioredoxin reductase 0.0042 0.0178 0.0606
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0204
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.0487 0.0469
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0058 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.2227 0.2386
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0066 0.2113
Loa Loa (eye worm) hypothetical protein 0.0054 0.0246 0.0678
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.017 0.4192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0058 0.0038
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0075
Schistosoma mansoni caspase-3 (C14 family) 0.01 0.0511 0.1017
Echinococcus multilocularis microtubule associated protein 2 0.067 0.3802 0.4078
Mycobacterium ulcerans lipase LipD 0.0079 0.0391 0.1209
Brugia malayi RNA binding protein 0.0061 0.0291 0.1005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.0549 0.1418
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.002 0.0018
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0246 0.4386
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0058 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0023
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0058 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0619
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0058 0.0124
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0515 0.0496
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0184 0.0504
Schistosoma mansoni integrin beta subunit 0.0223 0.1221 0.2461
Entamoeba histolytica hypothetical protein 0.0074 0.0363 0.1879
Echinococcus granulosus intermediate filament protein 0.0053 0.0242 0.048
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0058 0.0126
Onchocerca volvulus 0.0079 0.0391 0.2547
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0246 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0054 0.017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0391 0.1209
Schistosoma mansoni microtubule-associated protein tau 0.067 0.3802 0.7709
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0236
Loa Loa (eye worm) oxidoreductase 0.0021 0.0058 0.0146
Plasmodium falciparum thioredoxin reductase 0.0042 0.0178 0.635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0054 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0058 0.1472
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0274 0.5258
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0246 0.618
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.008 0.0399 0.1112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.01 0.0266
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0351 0.1816
Brugia malayi intermediate filament protein 0.0053 0.0242 0.0835
Trichomonas vaginalis importin beta-1, putative 0.0047 0.021 0.1084
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0058 0.1013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0138 0.026
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0145 0.0392
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0232 0.8407
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0054 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0054 0.0136
Toxoplasma gondii ABC1 family protein 0.0079 0.0391 0.7573
Trichomonas vaginalis set domain proteins, putative 0.0274 0.1519 0.8052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0054 0.0052
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0106 0.0547 0.1716
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.002 0.0499
Loa Loa (eye worm) glutaminase 0.0268 0.1485 0.4181
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Brugia malayi TAR-binding protein 0.0061 0.0291 0.1005
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0145 0.3523
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0181 0.0187
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0024 0.0523
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0058 0.0055
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.017 0.0873
Echinococcus multilocularis sentrin specific protease 7 0.0148 0.0792 0.0844
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.002 0.0238
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1043 0.3661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0054 0.0136
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0054 0.0089
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.2118 0.746
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0184 0.4711
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Loa Loa (eye worm) integrin beta-2 0.0378 0.2118 0.5972
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0058 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0363 0.0716
Echinococcus granulosus sentrin specific protease 1 0.0013 0.001 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0178 0.4386
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0145 0.2724
Onchocerca volvulus 0.0079 0.0391 0.2547
Brugia malayi Calcitonin receptor-like protein seb-1 0.0408 0.2289 0.8061
Chlamydia trachomatis recombinase RecA 0.0106 0.0547 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0054 0.017
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0058 0.1472
Leishmania major GTP-binding protein, putative 0.0043 0.0184 0.4711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.01 0.0511 0.1026
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0391 0.0963
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.002 0.0027
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0399 0.1389
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.002 0.0256
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0148 0.0792 0.1588
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0054 0.017
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0194
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0057 0.0267 0.0739
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0058 0.0124
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0254 0.0495
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.002 0.0499
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0391 0.2051
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0145 0.0392
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0225 0.1237 0.25
Plasmodium falciparum metacaspase 1 0.0027 0.009 0.3003
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.008 0.0397 0.2082
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.017 0.0151
Brugia malayi hypothetical protein 0.0057 0.0267 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0145 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0316 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0066 0.025
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0058 0.0038
Echinococcus granulosus sentrin specific protease 7 0.0148 0.0792 0.1596
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Loa Loa (eye worm) hypothetical protein 0.0072 0.0351 0.0975
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.017 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0391 0.0373
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.017 0.0464
Brugia malayi nuclear hormone receptor 0.0021 0.0054 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0408 0.2289 0.6453
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0547 0.3095 1
Trypanosoma cruzi hypothetical protein 0.0013 0.001 0.0268
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Leishmania major hypothetical protein, conserved 0.0079 0.0391 1
Treponema pallidum recombinase A 0.0106 0.0547 0.2829
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0106 0.0547 0.1413
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0391 0.2051
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0058 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0316 0.0621
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0254 0.0503
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0145 0.3523
Brugia malayi hypothetical protein 0.0503 0.2837 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0181 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0351 0.1077
Mycobacterium ulcerans hypothetical protein 0.01 0.0515 0.1611
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Echinococcus multilocularis geminin 0.0865 0.4929 0.5288
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0068 0.0127
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0254 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0054 0.017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0054 0.017
Trypanosoma brucei unspecified product 0.0015 0.002 0.0256
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0181 0.0355
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0284 0.0557
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0184 0.0949
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0232 0.5919
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.017 0.0808
Mycobacterium tuberculosis Probable reductase 0.0096 0.0487 0.0469
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0058 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0351 0.1218
Loa Loa (eye worm) hypothetical protein 0.0052 0.0237 0.0652
Loa Loa (eye worm) hypothetical protein 0.0408 0.2289 0.6453
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0058 0.0255
Brugia malayi glutathione reductase 0.0042 0.0178 0.0606
Echinococcus multilocularis protein dispatched 1 0.0048 0.0215 0.0225
Onchocerca volvulus 0.0274 0.1519 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0054 0.0089
Echinococcus granulosus muscleblind protein 0.0161 0.0862 0.1739
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0024 0.0361
Leishmania major trypanothione reductase 0.0042 0.0178 0.4537
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0391 0.2051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0054 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0236
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.0487 0.0469
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0058 0.0146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0184 0.3505
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0054 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Mycobacterium tuberculosis Conserved protein 0.0079 0.0391 0.0373
Onchocerca volvulus 0.0035 0.0138 0.0874
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.1254
Loa Loa (eye worm) MBCTL1 0.0063 0.0298 0.0825
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.0549 0.0531
Echinococcus granulosus snurportin 1 0.0625 0.3543 0.7186
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0242 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0054 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0619
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0605 0.1692
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0888 0.2824
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0204
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0184 0.0362
Schistosoma mansoni ap endonuclease 0.0041 0.017 0.0325
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.017 0.0873
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0124 0.3167
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0054 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.002 0.0048
Plasmodium falciparum importin beta, putative 0.0059 0.0274 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Brugia malayi beta-lactamase family protein 0.0079 0.0391 0.1361
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0298 0.0593
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0145 0.0916
Trichomonas vaginalis ran, putative 0.0043 0.0184 0.0949
Schistosoma mansoni importin beta-1 0.0059 0.0274 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.068 0.2381
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0058 0.1472
Brugia malayi CHE-14 protein 0.0042 0.0181 0.0616
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1043 0.2099
Mycobacterium tuberculosis Conserved protein 0.0079 0.0391 0.0373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Echinococcus multilocularis caspase 0.01 0.0511 0.0542
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0058 0.0124
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0254 0.0266
Brugia malayi CXXC zinc finger family protein 0.0028 0.0097 0.032
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.002 0.0344
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0391 0.0373
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Giardia lamblia Sentrin specific protease, putative 0.0013 0.001 0.0023
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0013 0.001 0.0268
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0058 0.0038
Schistosoma mansoni ran 0.0043 0.0184 0.0354
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.002 0.0499
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0254 0.0503
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Trypanosoma cruzi metacaspase, putative 0.0027 0.009 0.2287
Brugia malayi steroid hormone receptor 0.0021 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0072 0.0351 0.0975
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0178 0.0158
Schistosoma mansoni hypothetical protein 0.0129 0.068 0.1362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0054 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0229 0.021
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0058 0.1013
Schistosoma mansoni hypothetical protein 0.0865 0.4929 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0246 0.0678
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0054 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0054 0.0098
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.009 0.0552
Brugia malayi hypothetical protein 0.0051 0.0232 0.0797
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0041 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0054 0.017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0246 0.0736
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0138 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0145 0.3696
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0605 0.1692
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0391 0.0775
Echinococcus multilocularis protein patched 0.0042 0.0181 0.0187
Brugia malayi Cell death protein 3 precursor 0.0027 0.009 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0291 0.057
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0097 0.0256
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.001 0.0023
Schistosoma mansoni pyruvate kinase 0.0019 0.0043 0.0066
Schistosoma mansoni cpg binding protein 0.0028 0.0097 0.0175
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0054 0.0318
Trichomonas vaginalis glutaminase, putative 0.0268 0.1485 0.7871
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0054 0.017
Plasmodium falciparum pyruvate kinase 0.0036 0.0145 0.51
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1043 0.2099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0363 0.0383
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0888 0.2396
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.068 0.1906
Loa Loa (eye worm) hypothetical protein 0.0052 0.0236 0.0649
Echinococcus granulosus caspase 3 0.0073 0.0357 0.0713
Leishmania major hypothetical protein, conserved 0.0051 0.0232 0.5919
Loa Loa (eye worm) hypothetical protein 0.0079 0.0391 0.109
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.017 0.4347
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0291 0.057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.002 0.0499
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0066 0.0151
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.0549 0.0531
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.002 0.0238
Schistosoma mansoni hypothetical protein 0.0397 0.2227 0.4507
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0274 0.6908
Schistosoma mansoni pyruvate kinase 0.0036 0.0145 0.0273
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0351 0.1077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0058 0.1791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0146
Mycobacterium ulcerans glutaminase 0.0268 0.1485 0.4765
Trypanosoma cruzi metacaspase, putative 0.0027 0.009 0.2287
Treponema pallidum fructose-bisphosphate aldolase 0.0338 0.1885 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0391 0.1361
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0751 0.08
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0058 0.1472
Loa Loa (eye worm) hypothetical protein 0.0166 0.0895 0.2514
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0058 0.0184
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0391 0.0373
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0316 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0058 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0391 0.2051
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0506 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0054 0.0052
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0181 0.0354
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.001 0.0087
Echinococcus multilocularis pyruvate kinase 0.0036 0.0145 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.0267 0.0739
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0391 0.2051
Brugia malayi glutaminase DH11.1 0.0268 0.1485 0.5223
Schistosoma mansoni hypothetical protein 0.0041 0.0172 0.0328
Trypanosoma cruzi metacaspase, putative 0.0027 0.009 0.2287
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.009 0.164
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.242
Echinococcus granulosus sentrin specific protease 8 0.0013 0.001 0.0009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0184 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0054 0.0136
Echinococcus multilocularis muscleblind protein 1 0.0161 0.0862 0.092
Onchocerca volvulus 0.0166 0.0895 0.5877
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0054 0.0318
Loa Loa (eye worm) Ulp1 protease 0.0013 0.001 0.0012
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0184 0.063
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0058 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0054 0.0052
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0357
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.002 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0145 0.3523
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.004
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0619
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0013 0.001 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0298 0.0593
Plasmodium falciparum glutathione reductase 0.0042 0.0178 0.635
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0066 0.1179
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0054 0.0098
Treponema pallidum licC protein (licC) 0.01 0.0515 0.2656
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0506 0.2645
Plasmodium vivax SET domain protein, putative 0.0035 0.0138 0.3356
Entamoeba histolytica hypothetical protein 0.002 0.0051 0.0216
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0184 0.4566
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0298 0.0313
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0075
Onchocerca volvulus 0.0028 0.0097 0.0599
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.002 0.0344
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0145 0.3696
Schistosoma mansoni ran 0.0043 0.0184 0.0354
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0225 0.1237 0.1322
Onchocerca volvulus 0.0103 0.0528 0.3447
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0058 0.1488
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0547 0.3095 0.3081
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.001 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0391 0.0775
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.002 0.0238
Echinococcus multilocularis expressed conserved protein 0.0093 0.0472 0.05
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.002 0.0072
Trypanosoma brucei metacaspase MCA2 0.0027 0.009 0.2075
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0051 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Brugia malayi Pre-SET motif family protein 0.0241 0.1327 0.4666
Schistosoma mansoni hypothetical protein 0.0129 0.068 0.1362
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0351 0.1218
Schistosoma mansoni hypothetical protein 0.0279 0.1544 0.3118
Schistosoma mansoni hypothetical protein 0.0041 0.0172 0.0328
Echinococcus multilocularis muscleblind protein 0.0161 0.0862 0.092
Brugia malayi Latrophilin receptor protein 2 0.0129 0.068 0.2381
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0391 0.0414
Echinococcus granulosus cpg binding protein 0.0029 0.0106 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0291 0.057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1885 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0181 0.0929
Echinococcus granulosus microtubule associated protein 2 0.067 0.3802 0.7711
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.017 0.049
Trypanosoma cruzi metacaspase, putative 0.0027 0.009 0.2287
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0058 0.0124
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0625 0.3543 1
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0751 0.1513
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0391 1
Brugia malayi Muscleblind-like protein 0.0161 0.0862 0.3024
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0279 0.1544 0.4348
Plasmodium vivax hypothetical protein, conserved 0.0027 0.009 0.2075
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0515 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0054 0.0136
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0024 0.0005
Leishmania major metacaspase, putative 0.0027 0.009 0.2287
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0058 0.0251
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0145 0.0738
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0184 0.4566
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0058 0.1254
Brugia malayi hypothetical protein 0.0166 0.0895 0.314
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0361
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0058 0.1254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0054 0.0089
Loa Loa (eye worm) hypothetical protein 0.0055 0.0254 0.07
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0058 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1043 0.1114
Mycobacterium ulcerans hypothetical protein 0.0079 0.0391 0.1209
Brugia malayi nuclear receptor NHR-88 0.0021 0.0054 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0363 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0282 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Brugia malayi RNA, U transporter 1 0.0167 0.0897 0.3145
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0239
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.242
Giardia lamblia NADPH oxidoreductase, putative 0.008 0.0397 0.2082
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0081 0.0379
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0058 0.0124
Trypanosoma brucei metacaspase 0.0027 0.009 0.2075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0058 0.0124
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0274 0.0287
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0054 0.0089
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.01 0.0515 0.1611
Brugia malayi beta-lactamase 0.0079 0.0391 0.1361
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0391 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.002 0.0051 0.0216
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.017 0.4347
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0547 0.3095 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0391 0.0373
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0254 0.1638
Entamoeba histolytica hypothetical protein 0.0023 0.0066 0.0297
Schistosoma mansoni glutaminase 0.0268 0.1485 0.2998
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.068 0.0724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0145 0.0392
Echinococcus multilocularis pyruvate kinase 0.0036 0.0145 0.0149
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0145 0.0407
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0058 0.0039
Echinococcus multilocularis GPCR, family 2 0.0129 0.068 0.0724
Echinococcus multilocularis musashi 0.0053 0.0242 0.0254
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0068 0.0067
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0066 0.0151
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0391 0.109
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.0487 0.0469
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.1327 0.3735
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0051 0.0239
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0054 0.0052
Plasmodium falciparum metacaspase-like protein 0.0027 0.009 0.3003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0054 0.0089
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.009 0.0295
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0058 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0397 0.2082
Schistosoma mansoni coup transcription factor 0.0021 0.0054 0.0089
Entamoeba histolytica hypothetical protein 0.0074 0.0363 0.1879
Echinococcus granulosus survival motor neuron protein 1 0.0503 0.2837 0.5752
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.009 0.0444
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0058 0.0056
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0351 0.1077
Loa Loa (eye worm) glutaminase 2 0.0268 0.1485 0.4181
Plasmodium falciparum thioredoxin reductase 0.0015 0.002 0.0344
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.002 0.0238
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0081 0.0213
Trypanosoma brucei Metacaspase-4 0.0027 0.009 0.2075
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.021 0.5358
Onchocerca volvulus 0.0072 0.0351 0.2279
Schistosoma mansoni hypothetical protein 0.0625 0.3543 0.7183
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0444
Echinococcus multilocularis pyruvate kinase 0.0029 0.0101 0.0102
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.01 0.0515 1
Schistosoma mansoni hypothetical protein 0.0129 0.068 0.1362
Plasmodium vivax importin-beta 2, putative 0.0059 0.0274 0.6908
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.002 0.0265
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0298 0.1031

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10000 nM Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay. ChEMBL. 12482416
IC50 (binding) = 10000 nM Inhibitory concentration against alphaV-beta3 integrin using vitronectin ELISA assay. ChEMBL. 12482416

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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