Detailed information for compound 695372

Basic information

Technical information
  • TDR Targets ID: 695372
  • Name: 2-[9-(3-chlorophenyl)-1-methyl-2,4-dioxo-7,8- dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetam ide
  • MW: 388.808 | Formula: C17H17ClN6O3
  • H donors: 1 H acceptors: 4 LogP: 1.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Cn1c(=O)n(C)c2c(c1=O)n1CCCN(c1n2)c1cccc(c1)Cl
  • InChi: 1S/C17H17ClN6O3/c1-21-14-13(15(26)24(17(21)27)9-12(19)25)23-7-3-6-22(16(23)20-14)11-5-2-4-10(18)8-11/h2,4-5,8H,3,6-7,9H2,1H3,(H2,19,25)
  • InChiKey: ZJWQIUBMDIDLHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[9-(3-chlorophenyl)-2,4-diketo-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetamide
  • 2-[9-(3-chlorophenyl)-1-methyl-2,4-dioxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]ethanamide
  • BAS 12521550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0105 0.0619 0.7227
Echinococcus multilocularis microtubule associated protein 2 0.1525 1 1
Brugia malayi mbt repeat family protein 0.0055 0.0287 0.1776
Brugia malayi Presenilin family protein 0.0089 0.0516 0.32
Echinococcus multilocularis Nicastrin 0.0044 0.0213 0.0183
Echinococcus granulosus cpg binding protein 0.0068 0.0375 0.0345
Echinococcus multilocularis dual specificity 0.0102 0.0602 0.0573
Giardia lamblia Pyruvate kinase 0.0038 0.0179 0.2665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.111
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0055 0.0805
Schistosoma mansoni pyruvate kinase 0.0038 0.0179 0.0179
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0017 0.0036 0.0005
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0106
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0849
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.008 0.0052
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0094 0.0879
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.008 0.0049
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0077 0.0469
Echinococcus multilocularis pyruvate kinase 0.0038 0.0179 0.0148
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0287 0.0257
Echinococcus multilocularis cpg binding protein 0.0068 0.0375 0.0345
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0351 0.2181
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0287 0.0257
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Schistosoma mansoni sodium/chloride dependent transporter 0.0017 0.0036 0.0036
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0052
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0179 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0295 0.3248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0287 0.0257
Loa Loa (eye worm) hypothetical protein 0.0055 0.0287 0.1787
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0179 0.2421
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.0828 0.0828
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0256 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0485
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.008 0.0532
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0102 0.0602 0.3747
Loa Loa (eye worm) MBCTL1 0.0062 0.0337 0.2098
Leishmania major pyruvate kinase 0.0038 0.0179 0.1382
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0337 0.0337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0497
Brugia malayi follicle stimulating hormone receptor 0.0255 0.1608 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.077
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0077 0.0469
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.6107
Echinococcus multilocularis pyruvate kinase 0.003 0.0125 0.0094
Entamoeba histolytica deoxycytidyl transferase, putative 0.0082 0.0467 0.7758
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0768
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0451 0.7493
Schistosoma mansoni pyruvate kinase 0.002 0.0055 0.0055
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1326
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.0055
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0897
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0213 0.1333 0.8291
Mycobacterium ulcerans hypothetical protein 0.0119 0.0714 0.1529
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Echinococcus multilocularis Nicastrin 0.0044 0.0213 0.0183
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0179 0.2114
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0651 0.4224 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0017 0.0036 0.0005
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Loa Loa (eye worm) serotonin transporter b 0.0099 0.0579 0.3603
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0094 0.1362
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.0688 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0497
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0036 0.053
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0103 0.1407
Entamoeba histolytica hypothetical protein 0.0027 0.0103 0.1707
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0082 0.0467 0.2907
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Echinococcus multilocularis dna polymerase eta 0.0139 0.0845 0.0816
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000060288 0.00000000037494
Brugia malayi hypothetical protein 0.0044 0.0213 0.1315
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0103 0.1496
Echinococcus multilocularis gamma secretase subunit aph 1 0.0213 0.1333 0.1306
Brugia malayi polk-prov protein 0.0056 0.0295 0.1827
Plasmodium vivax amine transporter, putative 0.0017 0.0036 0.053
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0651 0.4224 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0052
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0094 0.1109
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0179 0.0288
Echinococcus granulosus pyruvate kinase 0.0038 0.0179 0.0148
Echinococcus granulosus dna polymerase eta 0.0139 0.0845 0.0816
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0567
Trypanosoma cruzi Nicastrin, putative 0.0016 0.0031 0.0369
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0179 0.2114
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0651 0.4224 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0946
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0287 0.0287
Trichomonas vaginalis Nicastrin precursor, putative 0.0044 0.0213 0.2957
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0946
Echinococcus multilocularis dna polymerase kappa 0.0113 0.0669 0.064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000093134
Schistosoma mansoni hypothetical protein 0.038 0.2435 0.2435
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.0688 0.1466
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0714 0.1573
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0103 0.0107
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0916
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0599
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0144 0.1966
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0103 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0634
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Brugia malayi hypothetical protein 0.0017 0.0036 0.0214
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0451 0.0897
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Brugia malayi gamma-secretase subunit aph-1 0.0213 0.1333 0.8289
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Entamoeba histolytica presenilin 1 peptidase, putative 0.0089 0.0516 0.8562
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0731 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0099 0.0579 0.0579
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0082 0.0467 0.0438
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0072 0.0041
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0485
Leishmania major pyruvate kinase 0.0038 0.0179 0.1382
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0651 0.4224 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0082 0.0467 0.0467
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Schistosoma mansoni hypothetical protein 0.0338 0.2156 0.2156
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0318 0.0624
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0337 0.0307
Echinococcus granulosus nicalin 0.0016 0.0031 0.0000087646
Trichomonas vaginalis DNA polymerase eta, putative 0.0113 0.0669 1
Echinococcus multilocularis serotonin transporter 0.0099 0.0579 0.055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0256 0.158
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0669 0.7843
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0179 0.1099
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0688 0.1467
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0556 0.3451
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0227
Echinococcus multilocularis sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Echinococcus granulosus pyruvate kinase 0.0038 0.0179 0.0148
Echinococcus granulosus geminin 0.038 0.2435 0.2411
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0287 0.0287
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Brugia malayi mbt repeat family protein 0.0055 0.0287 0.1776
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0017 0.0036 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.077
Schistosoma mansoni microtubule-associated protein tau 0.1525 1 1
Leishmania major DNA damage repair protein, putative 0.0025 0.0094 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0602 0.0602
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0072 0.0434
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0897
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0451 0.0897
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0072 0.0041
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Echinococcus granulosus Nicastrin 0.0044 0.0213 0.0183
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0688 0.9404
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0077 0.0046
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0119 0.0714 0.1529
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0451 0.7493
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0669 0.1422
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0471 0.5575
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0077 0.0077
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0498
Toxoplasma gondii hypothetical protein 0.0017 0.0036 0.0499
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7133
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.098
Echinococcus granulosus presenilin 0.0089 0.0516 0.0486
Giardia lamblia DNA damage repair protein 0.0025 0.0094 0.0829
Leishmania major DNA polymerase kappa, putative 0.0025 0.0094 0.0285
Chlamydia trachomatis pyruvate kinase 0.0038 0.0179 0.2182
Giardia lamblia DINP protein human, muc B family 0.009 0.0517 1
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0077 0.0481
Onchocerca volvulus 0.0023 0.008 0.08
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0094 0.1109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0179 0.2421
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Onchocerca volvulus 0.0095 0.0556 0.9574
Loa Loa (eye worm) presenilin spe-4 0.0031 0.0132 0.0822
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0083 0.0471 0.644
Schistosoma mansoni ap endonuclease 0.0023 0.008 0.008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0057 0.0026
Loa Loa (eye worm) norepinephrine transporter 0.0099 0.0579 0.3603
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.008 0.112
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.1441
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.008 0.0668
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0089 0.0516 0.0516
Schistosoma mansoni cpg binding protein 0.0064 0.0351 0.0351
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0556 0.0556
Brugia malayi CXXC zinc finger family protein 0.0064 0.0351 0.2171
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0082 0.0467 0.0438
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0451 0.0897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0916
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Echinococcus multilocularis geminin 0.038 0.2435 0.2411
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0052
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0052
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0287 0.0287
Plasmodium falciparum pyruvate kinase 0.0038 0.0179 0.2182
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0688 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0072 0.0446
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000093134
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.0688 0.807
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0318 0.4331
Trypanosoma cruzi DNA polymerase eta, putative 0.0139 0.0845 1
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0266
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0567
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.3725
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0497
Onchocerca volvulus 0.0064 0.0351 0.5789
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0179 0.2442
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0072 0.077
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0017 0.0036 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0072 0.0041
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0072 0.0541
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0077 0.0567
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0946
Treponema pallidum licC protein (licC) 0.0119 0.0714 1
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0094 0.1109
Schistosoma mansoni sodium/chloride dependent transporter 0.0017 0.004 0.004
Plasmodium falciparum pyruvate kinase 2 0.002 0.0055 0.029
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0179 0.1099
Mycobacterium ulcerans hypothetical protein 0.008 0.0451 0.0897
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0077 0.0481
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Loa Loa (eye worm) hypothetical protein 0.0139 0.0845 0.5253
Schistosoma mansoni hypothetical protein 0.0917 0.5982 0.5982
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0318 0.4331
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0057 0.0026
Entamoeba histolytica hypothetical protein 0.0016 0.0031 0.0518
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.008 0.1163
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0072 0.0353
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7133
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.0898
Leishmania major DNA polymerase eta, putative 0.0139 0.0845 1
Echinococcus multilocularis presenilin enhancer 2 0.0084 0.048 0.045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0688 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0451 0.0897
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0103 0.102
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0031 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0113 0.0669 1
Mycobacterium ulcerans hypothetical protein 0.0119 0.0714 0.1529
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0768
Leishmania major DNA polymerase kappa, putative 0.009 0.0517 0.5767
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0077 0.0046
Schistosoma mansoni ap endonuclease 0.0023 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0295 0.3248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.1608 1
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0474 0.5612
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.008 0.0049
Trypanosoma brucei unspecified product 0.0057 0.0299 0.3295
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Schistosoma mansoni sodium-dependent amino acid transporter 0.0017 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) hypothetical protein 0.0062 0.0337 0.2098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.008 0.0107
Schistosoma mansoni cpg binding protein 0.0068 0.0375 0.0375
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1093
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0318 0.4632
Brugia malayi Protein kinase domain containing protein 0.0102 0.0602 0.3739
Trypanosoma brucei unspecified product 0.0057 0.0299 0.3295
Echinococcus granulosus sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1162
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.5958
Schistosoma mansoni hypothetical protein 0.038 0.2435 0.2435
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0497
Onchocerca volvulus 0.0099 0.0579 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0714 0.1573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0451 0.0944
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.0295 0.1837
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0094 0.1281
Trypanosoma brucei DNA polymerase eta, putative 0.0139 0.0845 1
Brugia malayi Presenilin-like protein At2g29900 0.0031 0.0132 0.0811
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0119 0.0714 0.976
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0467 0.2898
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0667
Onchocerca volvulus 0.0023 0.008 0.08
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0072 0.0041
Brugia malayi cytosol aminopeptidase 0.0023 0.0077 0.0469
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0467 0.0982
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.0688 0.8141
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0179 0.0238
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0337 0.0307
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0318 0.0576
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0102 0.0602 0.6867
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0103 0.1407
Trypanosoma brucei Aph-1 protein, putative 0.0083 0.0474 0.5443
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0221 0.1383 0.1356
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0221 0.1383 0.1356
Onchocerca volvulus 0.0055 0.0287 0.4621
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.008 0.0000095728
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.008 0.0485
Onchocerca volvulus 0.0023 0.008 0.08
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.008 0.1327
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0072 0.0541
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0094 0.0768
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0055 0.0332
Onchocerca volvulus 0.0023 0.008 0.08
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0102 0.0634
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0451 0.0897
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0497
Toxoplasma gondii hypothetical protein 0.0031 0.0132 0.1809
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7023
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0077 0.0077
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0017 0.0036 0.0214
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0179 0.1811
Echinococcus granulosus serotonin transporter 0.0099 0.0579 0.055
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0688 0.0659
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.008 0.0599
Echinococcus granulosus sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Echinococcus multilocularis presenilin 0.0089 0.0516 0.0486
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.0688 0.8141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Entamoeba histolytica protein kinase, putative 0.0102 0.0602 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0337 0.2088
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.0434
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0669 0.1422
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0017 0.0036 0.0005
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0052
Leishmania major DNA polymerase eta, putative 0.0083 0.0471 0.5165
Loa Loa (eye worm) histone methyltransferase 0.002 0.0057 0.0355
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0084 0.048 0.2983
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.008 0.0497
Onchocerca volvulus 0.008 0.0451 0.7644
Entamoeba histolytica protein kinase, putative 0.0102 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0446
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0451 0.7493
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0946
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0077 0.0469
Trypanosoma cruzi Nicastrin, putative 0.0016 0.0031 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0102 0.1692
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0103 0.102
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0103 0.0403
Loa Loa (eye worm) solute carrier family 6 member 4 0.0099 0.0579 0.3603
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0256 0.0225
Echinococcus multilocularis pyruvate kinase 0.0038 0.0179 0.0148
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1093
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0094 0.0768
Echinococcus granulosus presenilin enhancer 2 0.0084 0.048 0.045
Trichomonas vaginalis Nicastrin precursor, putative 0.0044 0.0213 0.2957
Mycobacterium ulcerans hypothetical protein 0.0025 0.0094 0.0033
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0106
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0072 0.119
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.6107
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0287 0.1787
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.008 0.0947
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.3725
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0451 0.0944
Echinococcus multilocularis sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.0898
Schistosoma mansoni hypothetical protein 0.0044 0.0213 0.0213
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0017 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Echinococcus multilocularis dnaJ subfamily B 0.0917 0.5982 0.597
Toxoplasma gondii exonuclease III APE 0.0023 0.008 0.1093
Schistosoma mansoni pyruvate kinase 0.0038 0.0179 0.0179
Brugia malayi hypothetical protein 0.0044 0.0213 0.1315
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.0688 0.7968
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0256 0.0225
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.0025 0.0092 0.075
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0094 0.0768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0256 0.1591
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0287 0.0257
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.0434
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Echinococcus granulosus dnaJ subfamily B 0.0917 0.5982 0.597
Loa Loa (eye worm) RecQ helicase 0.0022 0.0072 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Schistosoma mansoni DNA helicase recq5 0.0022 0.0072 0.0072
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0556 0.0527
Echinococcus granulosus bloom syndrome protein 0.0022 0.0072 0.0041
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0337 0.0307
Brugia malayi ImpB/MucB/SamB family protein 0.0139 0.0845 0.5247
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0072 0.0041
Echinococcus granulosus gamma secretase subunit aph 1 0.0213 0.1333 0.1306
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0688 0.0659
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0517 0.5978
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Schistosoma mansoni gamma-secretase subunit aph-1 0.0213 0.1333 0.1333
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0474 0.5612
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.008 0.0947
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0287 0.4621
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Schistosoma mansoni DNA helicase recq1 0.0022 0.0072 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0256 0.0225
Toxoplasma gondii hypothetical protein 0.0025 0.0092 0.1261
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0619 0.7227
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Toxoplasma gondii hypothetical protein 0.0017 0.0036 0.0499
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0094 0.0094
Brugia malayi gamma-secretase subunit pen-2 0.0084 0.048 0.2974
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Loa Loa (eye worm) hypothetical protein 0.0044 0.0213 0.1326
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0179 0.2596
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0517 0.1102
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0688 0.151
Echinococcus granulosus dual specificity 0.0102 0.0602 0.0573
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0337 0.0307
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0089 0.0516 0.5746
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0179 0.1811
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0055 0.0757
Echinococcus granulosus dna polymerase kappa 0.0113 0.0669 0.064
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0077 0.0046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0099 0.0579 0.0579
Schistosoma mansoni DNA polymerase eta 0.0139 0.0845 0.0845
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0451 0.0897
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0103 0.0055
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1093
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0556 0.0527
Schistosoma mansoni cpg binding protein 0.0068 0.0375 0.0375
Entamoeba histolytica hypothetical protein 0.0102 0.0602 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Loa Loa (eye worm) hypothetical protein 0.0095 0.0556 0.3459
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0082 0.0467 0.0467
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Echinococcus multilocularis nicalin 0.0016 0.0031 0.0000087646
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0517 0.5767
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0688 0.1467
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0103 0.0881
Treponema pallidum sodium- and chloride- dependent transporter 0.0099 0.0579 0.8118
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0227
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0094 0.1109
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0099 0.0579 0.3595
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0669 0.7843

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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