Detailed information for compound 695372

Basic information

Technical information
  • TDR Targets ID: 695372
  • Name: 2-[9-(3-chlorophenyl)-1-methyl-2,4-dioxo-7,8- dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetam ide
  • MW: 388.808 | Formula: C17H17ClN6O3
  • H donors: 1 H acceptors: 4 LogP: 1.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Cn1c(=O)n(C)c2c(c1=O)n1CCCN(c1n2)c1cccc(c1)Cl
  • InChi: 1S/C17H17ClN6O3/c1-21-14-13(15(26)24(17(21)27)9-12(19)25)23-7-3-6-22(16(23)20-14)11-5-2-4-10(18)8-11/h2,4-5,8H,3,6-7,9H2,1H3,(H2,19,25)
  • InChiKey: ZJWQIUBMDIDLHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[9-(3-chlorophenyl)-2,4-diketo-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]acetamide
  • 2-[9-(3-chlorophenyl)-1-methyl-2,4-dioxo-7,8-dihydro-6H-purino[8,7-b]pyrimidin-3-yl]ethanamide
  • BAS 12521550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.008 0.112
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0119 0.0714 0.1529
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0179 0.1099
Leishmania major DNA polymerase kappa, putative 0.0025 0.0094 0.0285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Onchocerca volvulus 0.0099 0.0579 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.008 0.0599
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0077 0.0077
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.0898
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0446
Onchocerca volvulus 0.008 0.0451 0.7644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.008 0.0049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0946
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0072 0.0541
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.008 0.0485
Echinococcus multilocularis dnaJ subfamily B 0.0917 0.5982 0.597
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0318 0.4632
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0017 0.0036 0.0005
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0017 0.0036 0.0005
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0103 0.102
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0115 0.0688 0.7968
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0599
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.0055
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0179 0.0238
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0688 0.1467
Trypanosoma brucei Aph-1 protein, putative 0.0083 0.0474 0.5443
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Mycobacterium ulcerans hypothetical protein 0.0025 0.0094 0.0033
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0556 0.0527
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0556 0.0556
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0072 0.119
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0669 0.7843
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0072 0.0041
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0318 0.0624
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0017 0.0036 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.008 0.0000095728
Trypanosoma brucei unspecified product 0.0057 0.0299 0.3295
Entamoeba histolytica hypothetical protein 0.0016 0.0031 0.0518
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.008 0.1326
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0094 0.0879
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0179 0.2114
Echinococcus granulosus pyruvate kinase 0.0038 0.0179 0.0148
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0337 0.2088
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0179 0.0238
Schistosoma mansoni DNA helicase recq1 0.0022 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.008 0.0052
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0897
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.6107
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0094 0.0768
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0451 0.7493
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0451 0.0944
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Brugia malayi gamma-secretase subunit pen-2 0.0084 0.048 0.2974
Schistosoma mansoni sodium-dependent amino acid transporter 0.0017 0.0036 0.0036
Leishmania major DNA polymerase kappa, putative 0.009 0.0517 0.5767
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0102 0.0602 0.3747
Schistosoma mansoni hypothetical protein 0.038 0.2435 0.2435
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0106
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0083 0.0471 0.644
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0094 0.1281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Onchocerca volvulus 0.0064 0.0351 0.5789
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0072 0.0041
Toxoplasma gondii hypothetical protein 0.0017 0.0036 0.0499
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.098
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0055 0.0805
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0287 0.4621
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0077 0.0469
Giardia lamblia Pyruvate kinase 0.0038 0.0179 0.2665
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.008 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0103 0.0881
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.008 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0946
Echinococcus granulosus gamma secretase subunit aph 1 0.0213 0.1333 0.1306
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0517 0.5978
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0688 1
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0688 0.0659
Schistosoma mansoni pyruvate kinase 0.0038 0.0179 0.0179
Brugia malayi ImpB/MucB/SamB family protein 0.0139 0.0845 0.5247
Chlamydia trachomatis pyruvate kinase 0.0038 0.0179 0.2182
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.5958
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.008 0.008
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Brugia malayi Protein kinase domain containing protein 0.0102 0.0602 0.3739
Schistosoma mansoni hypothetical protein 0.038 0.2435 0.2435
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.008 0.0532
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.008 0.0897
Brugia malayi polk-prov protein 0.0056 0.0295 0.1827
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.008 0.0049
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0072 0.0041
Entamoeba histolytica protein kinase, putative 0.0102 0.0602 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.008 0.1093
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.008 0.0052
Onchocerca volvulus 0.0023 0.008 0.08
Schistosoma mansoni terminal deoxycytidyl transferase 0.0082 0.0467 0.0467
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.0898
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0055 0.0757
Trypanosoma brucei DNA polymerase eta, putative 0.0139 0.0845 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0082 0.0467 0.2907
Toxoplasma gondii hypothetical protein 0.0031 0.0132 0.1809
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0256 0.0225
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.008 0.0946
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0287 0.0257
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Brugia malayi follicle stimulating hormone receptor 0.0255 0.1608 1
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0094 0.1362
Plasmodium falciparum pyruvate kinase 2 0.002 0.0055 0.029
Onchocerca volvulus 0.0023 0.008 0.08
Schistosoma mansoni sodium/chloride dependent transporter 0.0099 0.0579 0.0579
Brugia malayi gamma-secretase subunit aph-1 0.0213 0.1333 0.8289
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0103 0.1496
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0337 0.0307
Giardia lamblia DINP protein human, muc B family 0.009 0.0517 1
Mycobacterium ulcerans hypothetical protein 0.0119 0.0714 0.1529
Treponema pallidum sodium- and chloride- dependent transporter 0.0099 0.0579 0.8118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0179 0.2114
Echinococcus multilocularis dna polymerase eta 0.0139 0.0845 0.0816
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0688 0.1467
Schistosoma mansoni hypothetical protein 0.0917 0.5982 0.5982
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.0434
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0072 0.0541
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0474 0.5612
Echinococcus granulosus dnaJ subfamily B 0.0917 0.5982 0.597
Plasmodium falciparum pyruvate kinase 0.0038 0.0179 0.2182
Echinococcus granulosus bloom syndrome protein 0.0022 0.0072 0.0041
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0094 0.1109
Echinococcus granulosus nicalin 0.0016 0.0031 0.0000087646
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0094 0.0768
Entamoeba histolytica presenilin 1 peptidase, putative 0.0089 0.0516 0.8562
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0451 0.0897
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0337 0.0307
Echinococcus multilocularis sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0688 0.9404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0179 0.1811
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0102 0.0602 0.6867
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0106
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0094 0.0768
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0451 0.7493
Echinococcus granulosus sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0179 0.1099
Mycobacterium ulcerans hypothetical protein 0.0119 0.0714 0.1529
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0916
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0451 0.0897
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0072 0.0446
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0451 0.0897
Echinococcus multilocularis dual specificity 0.0102 0.0602 0.0573
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0072 0.0041
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0103 0.0403
Loa Loa (eye worm) hypothetical protein 0.0095 0.0556 0.3459
Brugia malayi hypothetical protein 0.0017 0.0036 0.0214
Trichomonas vaginalis Nicastrin precursor, putative 0.0044 0.0213 0.2957
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0077 0.0077
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.008 0.0946
Echinococcus multilocularis pyruvate kinase 0.003 0.0125 0.0094
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.008 0.0052
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0179 0.2421
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0077 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.008 0.0497
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0139 0.0845 0.5253
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Plasmodium vivax amine transporter, putative 0.0017 0.0036 0.053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0094 0.1109
Loa Loa (eye worm) hypothetical protein 0.0056 0.0295 0.1837
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.008 0.1327
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.008 0.0947
Echinococcus multilocularis pyruvate kinase 0.002 0.0055 0.0024
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0094 0.0768
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0227
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.077
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Loa Loa (eye worm) norepinephrine transporter 0.0099 0.0579 0.3603
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0017 0.0036 0.0005
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0084 0.048 0.2983
Trypanosoma brucei unspecified product 0.0057 0.0299 0.3295
Toxoplasma gondii hypothetical protein 0.0017 0.0036 0.0499
Loa Loa (eye worm) MBCTL1 0.0062 0.0337 0.2098
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0017 0.0036 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0318 0.0576
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.008 0.0485
Echinococcus multilocularis nicalin 0.0016 0.0031 0.0000087646
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Echinococcus multilocularis pyruvate kinase 0.0038 0.0179 0.0148
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.008 0.0947
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.008 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0318 0.4331
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0221 0.1383 0.1356
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.0688 0.1466
Brugia malayi Presenilin family protein 0.0089 0.0516 0.32
Brugia malayi mbt repeat family protein 0.0055 0.0287 0.1776
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0094 0.1109
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0055 0.0332
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.008 0.0052
Echinococcus multilocularis dna polymerase kappa 0.0113 0.0669 0.064
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0103 0.1407
Echinococcus multilocularis cpg binding protein 0.0068 0.0375 0.0345
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0256 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Leishmania major DNA polymerase eta, putative 0.0139 0.0845 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0017 0.0036 0.0005
Schistosoma mansoni DNA helicase recq5 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.111
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7133
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Echinococcus granulosus cpg binding protein 0.0068 0.0375 0.0345
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0651 0.4224 1
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0669 0.1422
Leishmania major DNA polymerase eta, putative 0.0083 0.0471 0.5165
Echinococcus multilocularis gamma secretase subunit aph 1 0.0213 0.1333 0.1306
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0082 0.0467 0.0438
Echinococcus granulosus dna polymerase kappa 0.0113 0.0669 0.064
Schistosoma mansoni ap endonuclease 0.0023 0.008 0.008
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.0055
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0089 0.0516 0.0516
Schistosoma mansoni ap endonuclease 0.0023 0.008 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0256 0.1591
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0337 0.0307
Loa Loa (eye worm) hypothetical protein 0.0044 0.0213 0.1326
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.008 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Echinococcus multilocularis geminin 0.038 0.2435 0.2411
Trypanosoma cruzi Nicastrin, putative 0.0016 0.0031 0.0369
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0256 0.158
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Trichomonas vaginalis Nicastrin precursor, putative 0.0044 0.0213 0.2957
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0077 0.0481
Giardia lamblia DNA damage repair protein 0.0025 0.0094 0.0829
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Loa Loa (eye worm) presenilin spe-4 0.0031 0.0132 0.0822
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0451 0.0897
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0471 0.5575
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0651 0.4224 1
Echinococcus granulosus serotonin transporter 0.0099 0.0579 0.055
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.008 0.0052
Leishmania major DNA damage repair protein, putative 0.0025 0.0094 0.0285
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.008 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0451 0.0897
Echinococcus multilocularis sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0688 0.0659
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0179 0.2442
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0077 0.0481
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0602 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0256 0.0225
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0337 0.0307
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0498
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0221 0.1383 0.1356
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.0025 0.0092 0.075
Trichomonas vaginalis DNA polymerase eta, putative 0.0113 0.0669 1
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0467 0.2898
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0077 0.0469
Echinococcus multilocularis Nicastrin 0.0044 0.0213 0.0183
Trypanosoma cruzi Nicastrin, putative 0.0016 0.0031 0.0369
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Onchocerca volvulus 0.0023 0.008 0.08
Trypanosoma brucei unspecified product 0.0105 0.0619 0.7227
Echinococcus granulosus pyruvate kinase 0.002 0.0055 0.0024
Loa Loa (eye worm) histone methyltransferase 0.002 0.0057 0.0355
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0094 0.0094
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0651 0.4224 1
Brugia malayi cytosol aminopeptidase 0.0023 0.0077 0.0469
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0103 0.0055
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Toxoplasma gondii propionate-CoA ligase 0.0023 0.008 0.1093
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Toxoplasma gondii exonuclease III APE 0.0023 0.008 0.1093
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0497
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0057 0.0026
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0287 0.0287
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.008 0.0668
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Schistosoma mansoni DNA polymerase eta 0.0139 0.0845 0.0845
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0017 0.0036 0.0036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0103 0.0107
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0213 0.1333 0.8291
Entamoeba histolytica hypothetical protein 0.0102 0.0602 1
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0287 0.0287
Echinococcus granulosus geminin 0.038 0.2435 0.2411
Echinococcus granulosus dual specificity 0.0102 0.0602 0.0573
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0451 0.0944
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0179 0.2617
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0688 0.151
Brugia malayi CXXC zinc finger family protein 0.0064 0.0351 0.2171
Brugia malayi mbt repeat family protein 0.0055 0.0287 0.1776
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.077
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0103 0.1441
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0077 0.0046
Brugia malayi Presenilin-like protein At2g29900 0.0031 0.0132 0.0811
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0474 0.5612
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Onchocerca volvulus 0.0095 0.0556 0.9574
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0227
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0077 0.0567
Echinococcus multilocularis Nicastrin 0.0044 0.0213 0.0183
Entamoeba histolytica hypothetical protein 0.0027 0.0103 0.1707
Schistosoma mansoni cpg binding protein 0.0068 0.0375 0.0375
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.008 0.0497
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0556 0.0527
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.008 0.0052
Echinococcus granulosus Nicastrin 0.0044 0.0213 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0256 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0499
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.008 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0089 0.0516 0.7632
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.1608 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000060288 0.00000000037494
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0451 0.4913
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0451 0.0897
Echinococcus multilocularis pyruvate kinase 0.0038 0.0179 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0634
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0517 0.5767
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0099 0.0579 0.3595
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0036 0.053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0297 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Brugia malayi hypothetical protein 0.0044 0.0213 0.1315
Leishmania major pyruvate kinase 0.0038 0.0179 0.1382
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0099 0.0579 0.0579
Brugia malayi AMP-binding enzyme family protein 0.008 0.0451 0.2798
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0916
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0072 0.0434
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0688 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.3725
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.008 0.0052
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0179 0.111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.098
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0651 0.4224 1
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0102 0.1692
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0714 0.1573
Treponema pallidum licC protein (licC) 0.0119 0.0714 1
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0077 0.0046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.008 0.1163
Schistosoma mansoni microtubule-associated protein tau 0.1525 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0102 0.0634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Loa Loa (eye worm) hypothetical protein 0.0102 0.0599 0.3725
Echinococcus multilocularis microtubule associated protein 2 0.1525 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0619 0.7227
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0287 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.391
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.0068 0.0375 0.0375
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0849
Schistosoma mansoni hypothetical protein 0.0044 0.0213 0.0213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.008 0.1093
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0451 0.7493
Mycobacterium ulcerans hypothetical protein 0.008 0.0451 0.0897
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0179 0.2421
Brugia malayi Presenilin spe-4 0.0031 0.0132 0.0811
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0017 0.0036 0.0214
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0077 0.0046
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0072 0.0353
Echinococcus multilocularis presenilin enhancer 2 0.0084 0.048 0.045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0467 0.0982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0031 0.0031
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0179 0.2596
Entamoeba histolytica deoxycytidyl transferase, putative 0.0082 0.0467 0.7758
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0057 0.0026
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.008 0.1162
Schistosoma mansoni gamma-secretase subunit aph-1 0.0213 0.1333 0.1333
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0082 0.0467 0.0467
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0082 0.0467 0.0438
Echinococcus granulosus presenilin 0.0089 0.0516 0.0486
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0072 0.077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0295 0.3248
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0017 0.0036 0.0214
Trypanosoma cruzi DNA polymerase eta, putative 0.0139 0.0845 1
Toxoplasma gondii hypothetical protein 0.0025 0.0092 0.1261
Onchocerca volvulus 0.0055 0.0287 0.4621
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.008 0.0667
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0669 0.1422
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0072 0.0041
Entamoeba histolytica protein kinase, putative 0.0102 0.0602 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0287 0.0287
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0072 0.0434
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0089 0.0516 0.5746
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0089 0.0516 0.6107
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0497
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0103 0.102
Echinococcus granulosus sodium and chloride dependent glycine 0.0017 0.0036 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0256 0.0225
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7023
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0077 0.0469
Brugia malayi hypothetical protein 0.0044 0.0213 0.1315
Loa Loa (eye worm) serotonin transporter b 0.0099 0.0579 0.3603
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0103 0.1407
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0669 0.7843
Leishmania major pyruvate kinase 0.0038 0.0179 0.1382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0022 0.00000000093134
Onchocerca volvulus 0.0023 0.008 0.08
Echinococcus granulosus dna polymerase eta 0.0139 0.0845 0.0816
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0351 0.2181
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0144 0.1966
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0094 0.1109
Schistosoma mansoni sodium/chloride dependent transporter 0.0017 0.0036 0.0036
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0074
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0287 0.0257
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0179 0.1811
Loa Loa (eye worm) hypothetical protein 0.0059 0.0318 0.1981
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0602 0.7133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0714 0.1573
Loa Loa (eye worm) hypothetical protein 0.0062 0.0337 0.2098
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0179 0.0288
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0115 0.0688 0.8141
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0119 0.0714 0.976
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.3603
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Plasmodium falciparum M17 leucyl aminopeptidase 0.0115 0.0688 1
Echinococcus multilocularis serotonin transporter 0.0099 0.0579 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0669 0.7843
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0295 0.3248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0669 0.7922
Brugia malayi hypothetical protein 0.0031 0.0132 0.0811
Loa Loa (eye worm) hypothetical protein 0.008 0.0451 0.2808
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0451 0.0897
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0077 0.0567
Loa Loa (eye worm) solute carrier family 6 member 4 0.0099 0.0579 0.3603
Schistosoma mansoni sodium/chloride dependent transporter 0.0017 0.004 0.004
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.008 0.0106
Echinococcus granulosus pyruvate kinase 0.0038 0.0179 0.0148
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0287 0.0257
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0287 0.1787
Echinococcus multilocularis presenilin 0.0089 0.0516 0.0486
Echinococcus granulosus presenilin enhancer 2 0.0084 0.048 0.045
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0103 0.0055
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000093134
Schistosoma mansoni cpg binding protein 0.0064 0.0351 0.0351
Loa Loa (eye worm) RecQ helicase 0.0022 0.0072 0.0446
Loa Loa (eye worm) hypothetical protein 0.0055 0.0287 0.1787
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0115 0.0688 0.8141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0517 0.1102
Brugia malayi AMP-binding enzyme family protein 0.0023 0.008 0.0485
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0318 0.4331
Schistosoma mansoni pyruvate kinase 0.0038 0.0179 0.0179
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0497
Schistosoma mansoni pyruvate kinase 0.002 0.0055 0.0055
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0556 0.3451
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0227
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0113 0.0669 1
Schistosoma mansoni hypothetical protein 0.0338 0.2156 0.2156
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0731 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.00000000093134
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0017 0.0036 0.0036
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0115 0.0688 0.807

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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