TDR Targets

Basic information

Technical information

TDR Targets ID: 705570
Name: N-(3-methoxyphenyl)-1-phenyl-N'-propylpyrazol o[4,5-e]pyrimidine-4,6-diamine
MW: 374.439 | Formula: C21H22N6O
H donors: 2 H acceptors: 3 LogP: 4.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCNc1nc(Nc2cccc(c2)OC)c2c(n1)n(nc2)c1ccccc1
InChi: 1S/C21H22N6O/c1-3-12-22-21-25-19(24-15-8-7-11-17(13-15)28-2)18-14-23-27(20(18)26-21)16-9-5-4-6-10-16/h4-11,13-14H,3,12H2,1-2H3,(H2,22,24,25,26)
InChiKey: JSISRSYRSNZKJJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-methoxyphenyl)-1-phenyl-N'-propyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine
(3-methoxyphenyl)-(1-phenyl-6-propylamino-pyrazolo[4,5-e]pyrimidin-4-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0292	0.1557	1
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0024	0.006	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0427	0.2317	1
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0024	0.006	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.026	0.1125
Schistosoma mansoni	histidyl-tRNA synthetase	0.0014	0.0006	0.0021
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.015	0.0646
Onchocerca volvulus		0.006	0.026	0.208
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0037	0.049
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Plasmodium vivax	threonine--tRNA ligase, putative	0.0024	0.006	0.0054
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0085	0.0367
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0044	0.0186
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0068	0.0305	0.1321
Leishmania major	ATP-dependent phosphofructokinase	0.0127	0.0636	0.8399
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0044	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	carboxylesterase	0.0068	0.0305	0.1316
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0037	0.025
Leishmania major	hypothetical protein, conserved	0.006	0.026	0.3384
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Plasmodium falciparum	calcium-dependent protein kinase 3	0.013	0.0656	0.065
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0638	0.2754
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.1279	0.552
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0016	0.0064
Echinococcus granulosus	solute carrier family 22	0.006	0.026	0.1125
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0118	0.0507
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0066	0.0294	0.3837
Onchocerca volvulus		0.004	0.0148	0.1178
Schistosoma mansoni	cpg binding protein	0.0063	0.0277	0.1199
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Brugia malayi	Thioredoxin reductase	0.0038	0.0138	0.0591
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Toxoplasma gondii	facilitative glucose transporter GT1	0.0424	0.2299	0.346
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0148	0.0756	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.013	0.0656	0.0981
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	Sugar transporter ERD6 protein	0.006	0.026	0.1125
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.008	0.0376	0.561
Loa Loa (eye worm)	carboxylesterase	0.0401	0.2167	0.9354
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus granulosus	cpg binding protein	0.0063	0.0277	0.1199
Trichomonas vaginalis	myo-inositol transporter, putative	0.006	0.026	0.1125
Leishmania major	trypanothione reductase	0.0038	0.0138	0.1764
Schistosoma mansoni	sodium/chloride dependent transporter	0.0049	0.0198	0.0856
Entamoeba histolytica	protein kinase, putative	0.013	0.0656	1
Echinococcus multilocularis	acetylcholinesterase	0.0401	0.2167	0.9427
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1243	0.5366
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0024	0.006	0.0161
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0029	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0016	0.007
Leishmania major	glucose transporter, lmgt3	0.0132	0.0662	0.8747
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0148	0.0788
Brugia malayi	amine oxidase, flavin-containing family protein	0.0021	0.0041	0.0171
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0024	0.0061	0.0083
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0132	0.0662	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0271	0.1442	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Brugia malayi	Dopamine receptor protein 1	0.0427	0.2317	1
Toxoplasma gondii	protein kinase, putative	0.1199	0.6633	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0292	0.1557	1
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0045	0.0178	0.1106
Treponema pallidum	sodium- and chloride- dependent transporter	0.0235	0.1243	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.002	0.0038	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0485	0.2104
Treponema pallidum	glycyl-tRNA synthetase	0.0014	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.006	0.026	0.1125
Brugia malayi	Carboxylesterase family protein	0.0401	0.2167	0.9353
Echinococcus granulosus	calcium dependent protein kinase	0.0122	0.0608	0.2639
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0037	0.0413
Loa Loa (eye worm)	carboxylesterase	0.0068	0.0305	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Onchocerca volvulus		0.006	0.026	0.208
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0041	0.0467
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0068	0.0305	0.1906
Entamoeba histolytica	histidyl-tRNA synthetase, putative	0.0014	0.0006	0.0005
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.013	0.0656	0.8662
Schistosoma mansoni	glycyl-tRNA synthetase	0.0024	0.006	0.0253
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0148	0.0788
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0148	0.0914
Echinococcus multilocularis	solute carrier family 22	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Schistosoma mansoni	hypothetical protein	0.0166	0.0857	0.3724
Entamoeba histolytica	hypothetical protein	0.0042	0.0161	0.2387
Brugia malayi	MH2 domain containing protein	0.0131	0.0661	0.2848
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0118	0.0169
Brugia malayi	hypothetical protein	0.0021	0.0041	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0024	0.006	0.0258
Loa Loa (eye worm)	hypothetical protein	0.002	0.0038	0.0164
Loa Loa (eye worm)	6-phosphofructokinase	0.0127	0.0636	0.2745
Schistosoma mansoni	glucose transporter	0.006	0.026	0.1125
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0014	0.0006	0.002
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.0617	0.8142
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0148	0.0756	0.1132
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.041	0.6181
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.015	0.0646
Onchocerca volvulus		0.004	0.0148	0.1178
Plasmodium falciparum	protoporphyrinogen oxidase	0.0021	0.0041	0.0035
Entamoeba histolytica	hypothetical protein	0.0042	0.0161	0.2387
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Brugia malayi	major facilitator superfamily protein	0.006	0.026	0.1116
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.008	0.0376	0.2412
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0127	0.0638	0.9729
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0041	0.0035
Toxoplasma gondii	hypothetical protein	0.004	0.015	0.0217
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0731	0.3176
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Schistosoma mansoni	lysyl-tRNA synthetase	0.0095	0.0456	0.1978
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0014	0.0006	0.0005
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0258	0.1114
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0148	0.189
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.006	0.026	0.1636
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0148	0.0756	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0068	0.0305	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Leishmania major	lysyl-tRNA synthetase, putative	0.0095	0.0456	0.5997
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0021	0.0041	0.0035
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Trypanosoma cruzi	hexose transporter, putative	0.006	0.026	0.3384
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0064
Trichomonas vaginalis	sugar transport protein, putative	0.006	0.026	0.1125
Giardia lamblia	Kinase, CMGC MAPK	0.0066	0.0294	0.4553
Schistosoma mansoni	lamin	0.0028	0.0085	0.0364
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0009	0.0031
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0118	0.0169
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Mycobacterium leprae	Probable lipase LipE	0.004	0.0148	0.1788
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Schistosoma mansoni	ap endonuclease	0.002	0.0037	0.0155
Plasmodium falciparum	threonine--tRNA ligase	0.0024	0.006	0.0054
Trypanosoma cruzi	hexose transporter, putative	0.0132	0.0662	0.8747
Schistosoma mansoni	cpg binding protein	0.0059	0.0258	0.1117
Echinococcus granulosus	caspase 8	0.002	0.0038	0.0159
Echinococcus granulosus	mitogen activated protein kinase	0.0066	0.0294	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0647
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0127	0.0636	0.8399
Trypanosoma brucei	metacaspase	0.002	0.0038	0.0427
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.015	0.0646
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.006	0.026	0.1636
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0016	0.0064
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0085	0.0361
Schistosoma mansoni	threonyl-tRNA synthetase	0.0014	0.0006	0.0021
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.0294	0.3837
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0127	0.0636	0.8399
Onchocerca volvulus		0.0021	0.0041	0.0319
Trypanosoma brucei	trypanothione reductase	0.0038	0.0138	0.1764
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0709	0.3078
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0009	0.0031
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0163	0.0237
Loa Loa (eye worm)	histidyl-tRNA synthetase	0.0014	0.0006	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0485	0.2104
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.015	0.0646
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0037	0.0155
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.015	0.0646
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0068	0.0305	0.1906
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.015	0.0646
Entamoeba histolytica	hypothetical protein	0.0095	0.0456	0.6924
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0118	0.1723
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0485	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.0636	0.9696
Schistosoma mansoni	hypothetical protein	0.0166	0.0857	0.3724
Brugia malayi	Carboxylesterase family protein	0.0068	0.0305	0.131
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0127	0.0636	0.5091
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.006	0.026	0.1585
Plasmodium falciparum	glutathione reductase	0.0038	0.0138	0.0132
Echinococcus multilocularis	acetylcholinesterase	0.0401	0.2167	0.9427
Leishmania major	glycyl tRNA synthetase, putative	0.0014	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.013	0.0656	0.283
Onchocerca volvulus		0.006	0.026	0.208
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0041	0.0467
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.002	0.0038	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0187	0.0806
Echinococcus multilocularis	cpg binding protein	0.0063	0.0277	0.1199
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0001	0.0006
Plasmodium vivax	calcium-dependent protein kinase, putative	0.013	0.0656	0.065
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Plasmodium falciparum	proline--tRNA ligase	0.0148	0.0756	0.075
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0037	0.016
Schistosoma mansoni	protein kinase	0.013	0.0656	0.2847
Trypanosoma cruzi	hexose transporter, putative	0.0072	0.0328	0.4299
Schistosoma mansoni	acetylcholinesterase	0.0068	0.0305	0.1321
Onchocerca volvulus		0.006	0.026	0.208
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0123	0.0617	0.4124
Echinococcus multilocularis	carboxylesterase 5A	0.0401	0.2167	0.9427
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0235	0.1243	0.5405
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Schistosoma mansoni	glucose transport protein	0.0424	0.2299	1
Brugia malayi	glycyl-tRNA synthetase	0.0024	0.006	0.0251
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.006	0.026	0.1585
Schistosoma mansoni	6-phosphofructokinase	0.0127	0.0636	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0638	0.2754
Trypanosoma cruzi	hexose transporter, putative	0.0132	0.0662	0.8747
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.041	0.2655
Trypanosoma brucei	histidyl-tRNA synthetase	0.0014	0.0006	0.0005
Chlamydia trachomatis	proline--tRNA ligase	0.0045	0.0178	0.3815
Echinococcus granulosus	serotonin transporter	0.0235	0.1243	0.5405
Trichomonas vaginalis	spcc417.12 protein, putative	0.0068	0.0305	0.1321
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0021	0.0041	0.0035
Trypanosoma brucei	metacaspase 5, putative	0.002	0.0038	0.0427
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0014	0.0006	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Plasmodium vivax	amine transporter, putative	0.004	0.015	0.0144
Plasmodium falciparum	transporter, putative	0.004	0.015	0.0144
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0024	0.006	0.0258
Entamoeba histolytica	hypothetical protein	0.0042	0.0161	0.2387
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.0636	0.2762
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0068	0.0305	0.1321
Giardia lamblia	Threonyl-tRNA synthetase	0.0024	0.006	0.0849
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Toxoplasma gondii	ABC1 family protein	0.004	0.0148	0.0214
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0021	0.0041	0.0779
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0127	0.0638	0.2771
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1243	0.5366
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0083	0.0391	0.1694
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0211	0.091
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0014	0.0006	0.0005
Brugia malayi	6-phosphofructokinase	0.0127	0.0636	0.274
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Echinococcus multilocularis	neuroligin	0.0068	0.0305	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Giardia lamblia	Lysyl-tRNA synthetase	0.0095	0.0456	0.7117
Echinococcus multilocularis	musashi	0.0028	0.0085	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0085	0.0367
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0163	0.0703
Onchocerca volvulus		0.0028	0.0085	0.0673
Mycobacterium ulcerans	hypothetical protein	0.004	0.0148	0.0914
Onchocerca volvulus		0.006	0.026	0.208
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0148	0.189
Loa Loa (eye worm)	acetylcholinesterase 1	0.0401	0.2167	0.9354
Trypanosoma cruzi	hexose transporter	0.0132	0.0662	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0148	0.0142
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0016	0.0064
Schistosoma mansoni	ap endonuclease	0.002	0.0037	0.0155
Chlamydia trachomatis	lysine--tRNA ligase	0.0095	0.0456	1
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0029	0.0125
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0148	0.1788
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0037	0.0031
Schistosoma mansoni	caspase-7 (C14 family)	0.0067	0.0299	0.1293
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0132	0.0662	0.8747
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0118	0.0112
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.002	0.0038	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Onchocerca volvulus		0.006	0.026	0.208
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Plasmodium falciparum	calcium-dependent protein kinase 4	0.013	0.0656	0.065
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0009	0.0031
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0217
Echinococcus granulosus	mitogen activated protein kinase 3	0.0066	0.0294	0.1272
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.002	0.0038	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0401	0.2167	0.9354
Brugia malayi	beta-lactamase family protein	0.004	0.0148	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0068	0.0305	0.1321
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0148	0.0756	1
Loa Loa (eye worm)	hypothetical protein	0.0401	0.2167	0.9354
Toxoplasma gondii	exonuclease III APE	0.002	0.0037	0.0047
Schistosoma mansoni	caspase-7 (C14 family)	0.002	0.0038	0.0159
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0024	0.006	0.0253
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.0617	0.0921
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0148	0.0637
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.0636	0.9696
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Plasmodium falciparum	hexose transporter	0.0424	0.2299	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0014	0.0006	0.002
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0143	0.217
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0037	0.0155
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0143	0.2111
Echinococcus granulosus	lamin dm0	0.0028	0.0085	0.0364
Brugia malayi	hypothetical protein	0.006	0.026	0.1116
Leishmania major	histidyl-tRNA synthetase, putative	0.0014	0.0006	0.0005
Schistosoma mansoni	protein kinase	0.013	0.0656	0.2847
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0163	0.0237
Entamoeba histolytica	phosphofructokinase, putative	0.0127	0.0636	0.9696
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0024	0.006	0.0715
Brugia malayi	Major Facilitator Superfamily protein	0.006	0.026	0.1116
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0029	0.0119
Echinococcus granulosus	lysyl tRNA synthetase	0.0095	0.0456	0.1978
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.0636	0.2762
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.002	0.0038	0.0159
Schistosoma mansoni	glucose transport protein	0.0424	0.2299	1
Trypanosoma cruzi	metacaspase 5, putative	0.002	0.0038	0.0427
Onchocerca volvulus		0.006	0.026	0.208
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0021	0.0041	0.0172
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.006	0.026	0.0254
Brugia malayi	beta-lactamase family protein	0.004	0.0148	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0715
Onchocerca volvulus		0.0028	0.0085	0.0673
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0044	0.0508
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.015	0.0646
Echinococcus granulosus	intermediate filament protein	0.0028	0.0085	0.0364
Onchocerca volvulus		0.004	0.015	0.1194
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0024	0.006	0.0312
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0014	0.0006	0.002
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.015	0.0641
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0038	0.0032
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0127	0.0638	0.2771
Onchocerca volvulus		0.0068	0.0305	0.2443
Schistosoma mansoni	gliotactin	0.0068	0.0305	0.1321
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0021	0.0041	0.0172
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.0617	0.2678
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0001	0.0006
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0041	0.0035
Echinococcus granulosus	acetylcholinesterase	0.0401	0.2167	0.9427
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Mycobacterium tuberculosis	Conserved protein	0.004	0.0148	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0211	0.091
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Plasmodium falciparum	protein kinase 7	0.1199	0.6633	0.6631
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0211	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Onchocerca volvulus	Cell death protein 3 homolog	0.0067	0.0299	0.2393
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0138	0.1764
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus granulosus	dnaJ subfamily B	0.0414	0.2243	0.9754
Trichomonas vaginalis	sugar transporter, putative	0.0132	0.0662	0.2876
Echinococcus multilocularis	calcium dependent protein kinase	0.0122	0.0608	0.2639
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0037	0.1221
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0014	0.0006	0.0022
Echinococcus multilocularis	dnaJ subfamily B	0.0414	0.2243	0.9754
Trypanosoma cruzi	metacaspase, putative	0.002	0.0038	0.0427
Schistosoma mansoni	protein kinase	0.013	0.0656	0.2847
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0082	0.0355
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.015	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0121	0.0521
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.0661	0.2852
Trichomonas vaginalis	sugar transporter, putative	0.0132	0.0662	0.2876
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0138	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Toxoplasma gondii	glycyl-tRNA synthetase	0.0024	0.006	0.0081
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0066	0.0294	0.0434
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.013	0.0656	0.0981
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0021	0.0041	0.0172
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.013	0.0656	0.283
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Onchocerca volvulus		0.004	0.0148	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0505	0.2178
Echinococcus multilocularis	glycyl tRNA synthetase	0.0024	0.006	0.0253
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.0294	0.1273
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.002	0.0038	0.0158
Echinococcus multilocularis	serotonin transporter	0.0235	0.1243	0.5405
Echinococcus granulosus	GPCR family 2	0.0016	0.0016	0.0064
Loa Loa (eye worm)	serotonin transporter b	0.0235	0.1243	0.5366
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0148	0.0788
Mycobacterium leprae	conserved hypothetical protein	0.0021	0.0044	0.0052
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.0294	0.3837
Plasmodium vivax	glycine--tRNA ligase, putative	0.0024	0.006	0.0054
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Plasmodium falciparum	calcium-dependent protein kinase 5	0.013	0.0656	0.065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0485	0.2104
Mycobacterium ulcerans	histidyl-tRNA synthetase	0.0014	0.0006	0.0002
Echinococcus granulosus	lamin	0.0028	0.0085	0.0364
Onchocerca volvulus	Putative transporter	0.006	0.026	0.208
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0047	0.0187	0.0806
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0021	0.0041	0.0172
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Schistosoma mansoni	hypothetical protein	0.0424	0.2299	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0068	0.0305	0.1906
Mycobacterium tuberculosis	Probable oxidoreductase	0.0096	0.0464	0.3039
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0021	0.0041	0.0035
Mycobacterium ulcerans	monoamine oxidase	0.0021	0.0041	0.0226
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.015	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.026	0.1125
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0161	0.0695
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0024	0.006	0.0251
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0003	0.0006
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.015	0.0646
Trypanosoma cruzi	metacaspase, putative	0.002	0.0038	0.0427
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0132	0.0662	0.8747
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0148	0.189
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.015	0.0646
Giardia lamblia	Glycyl-tRNA synthetase	0.0024	0.006	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Brugia malayi	lysyl-tRNA synthetase	0.0095	0.0456	0.1962
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0011	0.0049
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0096	0.0464	0.7086
Schistosoma mansoni	hypothetical protein	0.0414	0.2243	0.9754
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0024	0.006	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Entamoeba histolytica	hypothetical protein	0.0042	0.0161	0.2387
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0044	0.0186
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0235	0.1243	0.5363
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0037	0.0413
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0127	0.0638	1
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0014	0.0006	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0294	0.1272
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.0294	0.1273
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0028	0.0113
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.0662	0.2876
Brugia malayi	Major Facilitator Superfamily protein	0.006	0.026	0.1116
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0068	0.0305	0.1321
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0235	0.1243	0.5366
Plasmodium vivax	sugar transporter, putative	0.006	0.026	0.0254
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.015	0.0646
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Toxoplasma gondii	histone lysine-specific demethylase	0.0021	0.0041	0.0053
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0148	0.0632
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.0001	0.0006
Toxoplasma gondii	transporter, major facilitator family protein	0.006	0.026	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus multilocularis	caspase 8	0.002	0.0038	0.0159
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	solute carrier family 22	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0127	0.0638	0.2749
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0485	0.2104
Echinococcus granulosus	solute carrier family 22	0.006	0.026	0.1125
Echinococcus granulosus	apoptotic protease activating factor 1	0.0047	0.0187	0.0806
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0686	0.3763	0.567
Echinococcus multilocularis	lysyl tRNA synthetase	0.0095	0.0456	0.1978
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0041	0.0172
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0217
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.0001	0.0006
Onchocerca volvulus		0.0068	0.0305	0.2443
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.0132	0.0662	0.2876
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0148	0.0637
Schistosoma mansoni	histidyl-tRNA synthetase	0.0014	0.0006	0.0021
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0118	0.2488
Echinococcus multilocularis	caspase 2	0.0067	0.0299	0.1293
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0014	0.0006	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.026	0.1125
Schistosoma mansoni	6-phosphofructokinase	0.0127	0.0636	0.2762
Trypanosoma cruzi	sugar transporter, putative	0.006	0.026	0.3384
Loa Loa (eye worm)	major facilitator superfamily transporter	0.006	0.026	0.1121
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0085	0.0367
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.0661	0.2852
Mycobacterium tuberculosis	Conserved protein	0.004	0.0148	0.0788
Trypanosoma cruzi	metacaspase, putative	0.002	0.0038	0.0427
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.013	0.0656	0.2825
Schistosoma mansoni	glucose transport protein	0.0424	0.2299	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0021	0.0041	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0299	0.1289
Brugia malayi	Sugar transporter family protein	0.0424	0.2299	0.9922
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Brugia malayi	major facilitator superfamily protein	0.006	0.026	0.1116
Trypanosoma brucei	glucose transporter 1E	0.0132	0.0662	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0148	0.0637
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.0001	0.0006
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0126	0.063	0.2736
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0456	0.1967
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.006	0.026	0.3384
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus granulosus	caspase 2	0.0067	0.0299	0.1293
Brugia malayi	Aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0731	0.3176
Leishmania major	glucose transporter, lmgt1	0.0132	0.0662	0.8747
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.015	0.0646
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0009	0.0031
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0024	0.006	0.0253
Echinococcus multilocularis	lamin dm0	0.0028	0.0085	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.0132	0.0662	0.2876
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.004	0.015	0.3196
Onchocerca volvulus		0.0047	0.0187	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0001	0.0006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0485	0.2087
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0016	0.0064
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0011	0.0043
Plasmodium vivax	hexose transporter	0.0424	0.2299	0.2294
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Schistosoma mansoni	cpg binding protein	0.0063	0.0277	0.1199
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0401	0.2167	0.9427
Echinococcus granulosus	geminin	0.0166	0.0857	0.3724
Brugia malayi	hypothetical protein	0.0042	0.0161	0.0689
Brugia malayi	Sugar transporter family protein	0.006	0.026	0.1116
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	carboxylesterase 5A	0.0401	0.2167	0.9427
Echinococcus granulosus	solute carrier family 22	0.006	0.026	0.1125
Treponema pallidum	prolyl-tRNA synthetase	0.0045	0.0178	0.1387
Onchocerca volvulus		0.004	0.015	0.1194
Brugia malayi	Carboxylesterase family protein	0.0068	0.0305	0.131
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0095	0.0456	0.6947
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0041	0.0172
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.015	0.0646
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.0617	0.3936
Echinococcus multilocularis	solute carrier family 22	0.006	0.026	0.1125
Brugia malayi	Carboxylesterase family protein	0.0068	0.0305	0.131
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0024	0.006	0.2114
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0148	0.0788
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0037	0.0155
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	sugar transporter	0.0424	0.2299	0.9922
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0068	0.0305	0.1321
Schistosoma mansoni	BC026374 protein (S09 family)	0.0068	0.0305	0.1321
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Toxoplasma gondii	sugar transporter ST2	0.006	0.026	0.0383
Echinococcus multilocularis	histidyl tRNA synthetase	0.0014	0.0006	0.0021
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.015	0.0646
Loa Loa (eye worm)	norepinephrine transporter	0.0235	0.1243	0.5366
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.0001	0.0006
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.015	0.0646
Leishmania major	glucose transporter, lmgt2	0.0132	0.0662	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.013	0.0656	0.283
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.041	0.2655
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0138	0.02
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0041	0.0177
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0066	0.0294	0.1272
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0148	0.0637
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.0636	0.2762
Plasmodium falciparum	amino acid transporter, putative	0.004	0.015	0.0144
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0044	0.0051
Echinococcus multilocularis	synaptic vesicle 2 protein	0.006	0.026	0.1125
Echinococcus multilocularis	geminin	0.0166	0.0857	0.3724
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0064
Leishmania major	metacaspase, putative	0.002	0.0038	0.0427
Trypanosoma cruzi	hexose transporter, putative	0.0132	0.0662	0.8747
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.006	0.026	0.1125
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Brugia malayi	Cam kinase protein 1	0.013	0.0656	0.2825
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Trypanosoma brucei	sugar transporter, putative	0.006	0.026	0.3384
Giardia lamblia	Hexose transporter	0.006	0.026	0.4016
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.015	0.0646
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0148	0.0637
Mycobacterium ulcerans	integral membrane transport protein	0.006	0.026	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0034	0.0118	0.0905
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0132	0.0662	0.8747
Schistosoma mansoni	sugar transporter	0.006	0.026	0.1125
Trichomonas vaginalis	interferon-induced, double-stranded RNA-activated protein kinase, putative	0.0014	0.0006	0.0022
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0044	0.0508
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.015	0.0646
Entamoeba histolytica	protein kinase, putative	0.013	0.0656	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.013	0.0656	0.0981
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.015	0.0646
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.002	0.0038	0.0048
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0148	0.0788
Leishmania major	hypothetical protein, conserved	0.004	0.0148	0.189
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0044	0.0508
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.041	0.2655
Trichomonas vaginalis	sugar transporter, putative	0.0132	0.0662	0.2876
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0211	0.0904
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.0617	0.2678
Brugia malayi	hypothetical protein	0.006	0.026	0.1116
Brugia malayi	phosphofructokinase	0.0127	0.0636	0.274
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0095	0.0456	0.1978
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0127	0.0638	0.2771
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0037	0.0031
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.0294	0.1273
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0148	0.0637
Schistosoma mansoni	sugar transporter	0.006	0.026	0.1125
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0003	0.0006
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0041	0.0029
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.006	0.026	1
Brugia malayi	hypothetical protein	0.004	0.015	0.0641
Plasmodium vivax	hypothetical protein, conserved	0.004	0.015	0.0144
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0138	0.0132
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0138	0.0132
Echinococcus granulosus	General substrate transporter	0.0365	0.1965	0.8548
Schistosoma mansoni	sugar transporter	0.006	0.026	0.1125
Onchocerca volvulus		0.006	0.026	0.208
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0003	0.0013
Brugia malayi	Carboxylesterase family protein	0.0068	0.0305	0.131
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0095	0.0456	0.29
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0148	0.0637
Mycobacterium ulcerans	lipase LipD	0.004	0.0148	0.0914
Mycobacterium ulcerans	carboxylesterase, LipT	0.0068	0.0305	0.1927
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0066	0.0294	0.3837
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0715
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0014	0.0006	0.002
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1243	0.5366
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0485	0.2104
Echinococcus granulosus	caspase	0.002	0.0038	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus multilocularis	para nitrobenzyl esterase	0.0068	0.0305	0.1321
Mycobacterium ulcerans	beta-lactamase	0.004	0.0148	0.0914
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.0041	0.0029
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0141	0.0608
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.006	0.026	0.1125
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.015	0.0646
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0485	0.2092
Plasmodium falciparum	calcium-dependent protein kinase 1	0.013	0.0656	0.065
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.0617	0.3936
Onchocerca volvulus		0.0235	0.1243	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.013	0.0656	0.065
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0066	0.0294	0.1268
Echinococcus multilocularis	General substrate transporter	0.0365	0.1965	0.8548
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0148	0.0788
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0016	0.0064
Trypanosoma brucei	metacaspase MCA3	0.002	0.0038	0.0427
Schistosoma mansoni	hypothetical protein	0.0042	0.0161	0.0695
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.013	0.0656	0.2847
Giardia lamblia	Prolyl-tRNA synthetase	0.0127	0.0638	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0095	0.0456	0.5997
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0305	0.1316
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Echinococcus granulosus	neuroligin	0.0068	0.0305	0.1321
Brugia malayi	beta-lactamase	0.004	0.0148	0.0632
Mycobacterium ulcerans	sugar transporter	0.006	0.026	0.1636
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0161	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0066	0.0294	0.3837
Schistosoma mansoni	lysyl-tRNA synthetase	0.0095	0.0456	0.1978
Echinococcus multilocularis	mitogen activated protein kinase	0.0066	0.0294	0.1272
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0038	0.016
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0641
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0118	0.0169
Schistosoma mansoni	hypothetical protein	0.0035	0.0121	0.0519
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0715
Treponema pallidum	threonyl-tRNA synthetase	0.0024	0.006	0.0434
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.026	0.1125
Mycobacterium tuberculosis	Conserved protein	0.004	0.0148	0.0788
Leishmania major	hypothetical protein, conserved	0.0021	0.0044	0.0508
Onchocerca volvulus		0.006	0.026	0.208
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0024	0.006	0.0258
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0118	0.0112
Echinococcus multilocularis		0.0021	0.0041	0.0172
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0731	0.3151
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0037	0.0413
Echinococcus multilocularis	solute carrier family 22	0.006	0.026	0.1125
Onchocerca volvulus		0.0068	0.0305	0.2443
Brugia malayi	Cell death protein 3 precursor	0.0067	0.0299	0.1283
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Plasmodium vivax	proline--tRNA ligase, putative	0.0148	0.0756	0.075
Brugia malayi	hypothetical protein	0.006	0.026	0.1116
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0037	0.0413
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0148	0.0637
Trichomonas vaginalis	phosphofructokinase, putative	0.0127	0.0636	0.2762
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.013	0.0656	0.065
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0118	0.1771
Echinococcus granulosus	BC026374 protein S09 family	0.0068	0.0305	0.1321
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0148	0.0637
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0014	0.0006	0.002
Loa Loa (eye worm)	63kd antigen	0.0014	0.0006	0.0026
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Plasmodium falciparum	lysine--tRNA ligase	0.0095	0.0456	0.045
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.1279	0.5517
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0686	0.3763	0.376
Toxoplasma gondii	histidyl-tRNA synthetase (HisRS), putative	0.0014	0.0006	0.0001
Loa Loa (eye worm)	phosphofructokinase	0.0127	0.0636	0.2745
Trypanosoma cruzi	glucose transporter, putative	0.006	0.026	0.3384
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0127	0.0638	0.2749
Loa Loa (eye worm)	sugar transporter	0.006	0.026	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0021	0.0041	0.0035
Brugia malayi	hypothetical protein	0.0068	0.0305	0.131
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Echinococcus granulosus	acetylcholinesterase	0.0401	0.2167	0.9427
Schistosoma mansoni	lamin	0.0028	0.0085	0.0364
Echinococcus multilocularis	solute carrier family 22	0.006	0.026	0.1125
Onchocerca volvulus		0.004	0.015	0.1194
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0641
Brugia malayi	Sugar transporter family protein	0.006	0.026	0.1116
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.0001	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.013	0.0656	0.2847
Brugia malayi	Carboxylesterase family protein	0.0401	0.2167	0.9353
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0143	0.0137
Schistosoma mansoni	sodium/chloride dependent transporter	0.0235	0.1243	0.5405
Schistosoma mansoni	amine oxidase	0.0021	0.0041	0.0172
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.0617	0.3936
Trypanosoma brucei	metacaspase MCA2	0.002	0.0038	0.0427
Echinococcus granulosus	histidyl tRNA synthetase	0.0014	0.0006	0.0021
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.0294	0.1273
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0686	0.3763	0.376
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.0662	0.2876
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.2299	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Loa Loa (eye worm)	6-phosphofructokinase	0.0127	0.0636	0.2745
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0037	0.02
Brugia malayi	glutathione reductase	0.0038	0.0138	0.0591
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0066	0.0294	0.3837
Loa Loa (eye worm)	major facilitator superfamily transporter	0.006	0.026	0.1121
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0096	0.0464	0.3039
Trichomonas vaginalis	CAMK family protein kinase	0.013	0.0656	0.2848
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0014	0.0006	0.002
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Brugia malayi	MAP kinase sur-1	0.0066	0.0294	0.1262
Toxoplasma gondii	sugar transporter ST3	0.006	0.026	0.0383
Loa Loa (eye worm)	beta-lactamase	0.004	0.0148	0.0638
Schistosoma mansoni	sugar transporter	0.006	0.026	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0096	0.0464	0.3039
Onchocerca volvulus		0.006	0.026	0.208
Loa Loa (eye worm)	hypothetical protein	0.004	0.015	0.0647
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0148	0.0638
Leishmania major	hypothetical protein, conserved	0.0021	0.0044	0.0508
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0138	0.0721
Onchocerca volvulus		0.006	0.026	0.208
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0148	0.0756	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0163	0.0703
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0016	0.007
Mycobacterium ulcerans	oxidoreductase	0.0021	0.0041	0.0226
Brugia malayi	SWIRM domain containing protein	0.0021	0.0041	0.0171
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0016	0.0064
Mycobacterium ulcerans	dehydrogenase	0.0021	0.0041	0.0226
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0118	0.0112
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0638
Plasmodium falciparum	calcium-dependent protein kinase 2	0.013	0.0656	0.065
Toxoplasma gondii	hypothetical protein	0.004	0.015	0.0217
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0148	0.0788
Schistosoma mansoni	amine oxidase	0.0021	0.0041	0.0172
Onchocerca volvulus		0.0059	0.0258	0.2066
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0163	0.0157
Leishmania major	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0715
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0044	0.0508
Onchocerca volvulus		0.006	0.026	0.208
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0037	0.0154
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.0617	0.2678
Echinococcus multilocularis	lamin	0.0028	0.0085	0.0364
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0127	0.0636	0.9965
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0068	0.0305	0.1321
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0024	0.006	0.0081
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0024	0.006	0.2114
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0095	0.0456	0.29
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0021	0.0044	0.0508
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Chlamydia trachomatis	histidine--tRNA ligase	0.0014	0.0006	0.0008
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0016	0.0064
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0138	0.0132
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0021	0.0044	0.0058
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0037	0.0477
Toxoplasma gondii	lysine-tRNA ligase	0.0095	0.0456	0.0679
Trypanosoma brucei	glucose transporter 2A	0.0132	0.0662	0.8747
Trypanosoma cruzi	metacaspase, putative	0.002	0.0038	0.0427
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0037	0.0155
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0024	0.006	0.0826
Trypanosoma brucei	glucose transporter, putative	0.0132	0.0662	0.8747
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0138	0.0597
Trypanosoma brucei	protein kinase, putative	0.0066	0.0294	0.3837
Echinococcus multilocularis	6 phosphofructokinase	0.0127	0.0636	0.2762
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.015	0.0646
Plasmodium falciparum	metacaspase-like protein	0.002	0.0038	0.0032
Echinococcus granulosus	glycyl tRNA synthetase	0.0024	0.006	0.0253
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0121	0.0515
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0148	0.0756	1
Brugia malayi	6-phosphofructokinase	0.0127	0.0636	0.274
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0001	0.0006
Plasmodium vivax	lysine--tRNA ligase, putative	0.0095	0.0456	0.045
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0161	0.0695
Echinococcus granulosus	6 phosphofructokinase	0.0127	0.0636	0.2762
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0253	0.1342	0.9284
Brugia malayi	intermediate filament protein	0.0028	0.0085	0.0361
Trypanosoma cruzi	histidyl-tRNA synthetase	0.0014	0.0006	0.0005
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0014	0.0006	0.002
Mycobacterium ulcerans	6-phosphofructokinase	0.0127	0.0636	0.4061
Toxoplasma gondii	anticodon binding domain-containing protein	0.0014	0.0006	0.0001
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.0617	0.2678
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0118	0.0507
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0116	0.0575	0.0858
Onchocerca volvulus		0.006	0.026	0.208
Plasmodium vivax	metacaspase 1, putative	0.002	0.0038	0.0032
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.041	0.2655
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0044	0.0186
Loa Loa (eye worm)	hypothetical protein	0.006	0.026	0.1121
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0258	0.1108
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.013	0.0656	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Onchocerca volvulus		0.006	0.026	0.208
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0009	0.0031
Onchocerca volvulus		0.0068	0.0305	0.2443
Brugia malayi	hypothetical protein	0.0047	0.0187	0.08
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0068	0.0305	0.1321
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0085	0.0364
Leishmania major	myo-inositol/proton symporter (MIT)	0.006	0.026	0.3384
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0068	0.0305	0.1321
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0118	0.0112
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Trypanosoma brucei	Metacaspase-4	0.002	0.0038	0.0427
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.013	0.0656	0.065
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Schistosoma mansoni	hypothetical protein	0.0047	0.0187	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0001	0.0006
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0066	0.0294	0.3837
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Brugia malayi	Major Facilitator Superfamily protein	0.006	0.026	0.1116
Mycobacterium tuberculosis	Probable reductase	0.0087	0.041	0.2655
Toxoplasma gondii	sugar transporter ST1	0.006	0.026	0.0383
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1801	1	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0148	0.0914
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0127	0.0638	0.2771
Plasmodium falciparum	metacaspase 1	0.002	0.0038	0.0032
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0424	0.2299	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0141	0.0608
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0485	0.2104
Chlamydia trachomatis	threonine--tRNA ligase	0.0024	0.006	0.1193
Leishmania major	UDP-galactopyranose mutase	0.0021	0.0041	0.0467
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0731	0.3156
Echinococcus multilocularis	caspase	0.002	0.0038	0.0159
Schistosoma mansoni	caspase-3 (C14 family)	0.002	0.0038	0.0159
Onchocerca volvulus		0.006	0.026	0.208
Onchocerca volvulus		0.0068	0.0305	0.2443
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0127	0.0638	0.2771
Onchocerca volvulus		0.006	0.026	0.208
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0118	0.2488
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0424	0.2299	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.008	0.0376	0.2412
Trichomonas vaginalis	esterase, putative	0.004	0.0148	0.0637
Trypanosoma cruzi	metacaspase 5, putative	0.002	0.0038	0.0427
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.015	0.0647
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.041	0.2655
Wolbachia endosymbiont of Brugia malayi	histidyl-tRNA synthetase	0.0014	0.0006	0.0014
Echinococcus granulosus	synaptic vesicle 2 protein	0.006	0.026	0.1125
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0095	0.0456	0.5997
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0127	0.0636	0.4262
Giardia lamblia	Sugar-proton symporter	0.006	0.026	0.4016
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0014	0.0006	0.002
Trichomonas vaginalis	sugar transporter, putative	0.006	0.026	0.1125
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.002	0.0038	0.016
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0064
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0163	0.0703
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0024	0.006	0.0826
Leishmania major	protein kinase, putative	0.013	0.0656	0.8662
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0052	0.0218	0.0943

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 705570