Detailed information for compound 73642

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.496 | Formula: C26H26N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC1CCCC1)C1(Cc2cc[n+](cc2)[O-])C(=O)Nc2c1cccc2
  • InChi: 1S/C26H26N2O4/c1-31-23-11-10-19(16-24(23)32-20-6-2-3-7-20)26(17-18-12-14-28(30)15-13-18)21-8-4-5-9-22(21)27-25(26)29/h4-5,8-16,20H,2-3,6-7,17H2,1H3,(H,27,29)
  • InChiKey: AHQFNBBFTLKREF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0547 0.7425 0.7425
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0066 0.0664 0.8827
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Loa Loa (eye worm) hypothetical protein 0.0116 0.1371 0.1925
Loa Loa (eye worm) cytochrome P450 0.0027 0.0115 0.0162
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0183 0.2312 0.304
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0115 0.0227
Onchocerca volvulus 0.0028 0.0125 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0121 0.0826
Brugia malayi nuclear hormone receptor 0.0086 0.0952 0.1337
Loa Loa (eye worm) hypothetical protein 0.004 0.0305 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.2542 0.2542
Brugia malayi hypothetical protein 0.0097 0.1097 0.1541
Brugia malayi Death domain containing protein 0.0033 0.0196 0.0275
Echinococcus multilocularis ecdysone induced protein 78C 0.0183 0.2312 0.2312
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.02 0.2542 0.3571
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0097 0.1097 0.1541
Brugia malayi RNA, U transporter 1 0.0097 0.1103 0.1549
Echinococcus granulosus thyroid hormone receptor alpha 0.0086 0.0952 0.1251
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0121 0.0281
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0115 0.1223
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0183 0.2312 0.3247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0199 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0749 1
Brugia malayi Nuclear hormone receptor E75 0.0086 0.0952 0.1337
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0664 0.5336
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0708 0.0995
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0316 0.0415
Brugia malayi Uncoordinated protein 44 0.0033 0.0196 0.0275
Brugia malayi Cytochrome P450 family protein 0.0067 0.0677 0.095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0038
Onchocerca volvulus 0.0102 0.1165 0.176
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0121 0.0248
Brugia malayi MAP kinase sur-1 0.006 0.0586 0.0823
Loa Loa (eye worm) hypothetical protein 0.0344 0.4572 0.6422
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0586 0.461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0125 0.1357
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Toxoplasma gondii PAN/Apple domain-containing protein 0.0066 0.066 0.4686
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0127 0.0726
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Schistosoma mansoni nuclear hormone receptor 0.0086 0.0952 0.0952
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.003
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0708 0.0932
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0183 0.2312 0.304
Schistosoma mansoni nuclear hormone receptor 0.0086 0.0952 0.0952
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1306 0.1718
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.1306 0.1306
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0708 0.0995
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0115 0.0698
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0183 0.2312 0.2312
Loa Loa (eye worm) hypothetical protein 0.0097 0.1097 0.1541
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0586 0.461
Loa Loa (eye worm) steroid hormone receptor 0.0183 0.2312 0.3247
Schistosoma mansoni zinc finger protein 0.0086 0.0952 0.0952
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Schistosoma mansoni netrin receptor unc5 0.0033 0.0196 0.0196
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0125 0.1357
Brugia malayi Trypsin family protein 0.0021 0.003 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0091 0.0127
Onchocerca volvulus 0.0066 0.066 0.0978
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0316 0.2095
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.066 0.0928
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0316 0.0316
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0433 0.3568
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.1115 0.1567
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0115 0.1223
Brugia malayi orphan nuclear receptor NR2E1 0.0086 0.0952 0.1337
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0749 0.0749
Schistosoma mansoni ap endonuclease 0.0041 0.0316 0.0316
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.1306 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0183 0.2312 0.3247
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0316 0.3644
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0115 0.1223
Brugia malayi nuclear receptor RXR 0.0097 0.1097 0.1541
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.0952 0.0952
Schistosoma mansoni hypothetical protein 0.0033 0.0196 0.0196
Entamoeba histolytica hypothetical protein 0.0075 0.079 1
Loa Loa (eye worm) CYP4Cod1 0.0066 0.0664 0.0933
Brugia malayi hypothetical protein 0.0027 0.0121 0.017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0127 0.0726
Schistosoma mansoni ap endonuclease 0.0041 0.0316 0.0316
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0148 0.0207
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.1097 0.1541
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0316 0.2095
Onchocerca volvulus Bile acid receptor homolog 0.0183 0.2312 0.3539
Toxoplasma gondii subtilisin SUB12 0.0066 0.066 0.4686
Onchocerca volvulus 0.0066 0.066 0.0978
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0086 0.0952 0.1337
Echinococcus granulosus geminin 0.056 0.7605 1
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Schistosoma mansoni nuclear receptor 0.0086 0.0952 0.0952
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0148 0.0207
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0115 0.0201
Brugia malayi Thioredoxin reductase 0.0049 0.0433 0.0608
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Echinococcus multilocularis tissue type plasminogen activator 0.0102 0.1165 0.1165
Trypanosoma brucei protein kinase, putative 0.006 0.0586 0.8017
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0218 0.2053
Schistosoma mansoni hypothetical protein 0.0547 0.7425 0.7425
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0183 0.2312 0.3247
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.1097 0.1541
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0148 0.0207
Plasmodium falciparum cysteine repeat modular protein 1 0.0102 0.1165 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0086 0.0952 0.0952
Echinococcus granulosus enteropeptidase 0.0021 0.003 0.0039
Schistosoma mansoni ran 0.0025 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0115 0.1223
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0196 0.0196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0183 0.2312 0.2312
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.02 0.2542 0.3571
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0115 0.0698
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0749 0.0749
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0097 0.1097 0.1541
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.1115 0.1567
Echinococcus granulosus lamin dm0 0.0029 0.0148 0.0194
Brugia malayi hypothetical protein 0.048 0.6478 0.9099
Loa Loa (eye worm) hypothetical protein 0.0097 0.1097 0.1541
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.003 0.003
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0115 0.1223
Leishmania major importin beta-1 subunit, putative 0.0028 0.0127 0.0335
Schistosoma mansoni lozenge 0.006 0.0583 0.0583
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0952 0.0952
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.066 0.0928
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.2542 0.3343
Echinococcus multilocularis Ankyrin 0.0033 0.0199 0.0199
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1306 0.1306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0183 0.2312 0.3247
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.003 0.0039
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0115 0.0227
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.066 0.0928
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0218 0.2053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0148 0.0207
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0299 0.0299
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0091 0.0091
Echinococcus multilocularis geminin 0.056 0.7605 0.7605
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0027 0.0106
Plasmodium vivax glutathione reductase, putative 0.0049 0.0433 0.3568
Schistosoma mansoni importin beta-1 0.0034 0.0218 0.0218
Onchocerca volvulus 0.0086 0.0952 0.143
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0115 0.0698
Loa Loa (eye worm) hypothetical protein 0.0097 0.1097 0.1541
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0183 0.2312 0.2312
Brugia malayi nuclear hormone receptor family member nhr-6 0.0086 0.0952 0.1337
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0586 0.0586
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0115 0.0698
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Schistosoma mansoni coup transcription factor 0.0183 0.2312 0.2312
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0121 0.0488
Onchocerca volvulus 0.0066 0.066 0.0978
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0433 0.0569
Echinococcus granulosus FTZ F1 alpha 0.0183 0.2312 0.304
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0125 0.0488
Schistosoma mansoni hypothetical protein 0.056 0.7605 0.7605
Echinococcus granulosus tumor protein p63 0.0386 0.516 0.6785
Loa Loa (eye worm) hypothetical protein 0.0034 0.0218 0.0306
Brugia malayi nuclear hormone receptor family member odr-7 0.0086 0.0952 0.1337
Loa Loa (eye worm) hypothetical protein 0.0112 0.1306 0.1835
Loa Loa (eye worm) nuclear hormone receptor 0.0086 0.0952 0.1337
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0183 0.2312 0.3247
Brugia malayi tailless protein 0.0086 0.0952 0.1337
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0433 0.3186
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0125 0.1357
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1501 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0708 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0125 0.0318
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0316 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0183 0.2312 0.3247
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0167 0.2084 0.2084
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0115 0.1223
Brugia malayi hypothetical protein 0.0278 0.3641 0.5114
Echinococcus granulosus nuclear receptor nhr 48 0.0086 0.0952 0.1251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.2542 0.2542
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0708 0.5751
Schistosoma mansoni nuclear receptor nhr-48 0.0086 0.0952 0.0952
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0531 0.0531
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0116 0.1371 0.1371
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0115 0.1223
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0115 0.1223
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0749 0.0749
Brugia malayi glutathione reductase 0.0049 0.0433 0.0608
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.1097 0.1097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0183 0.2312 0.2312
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0125 0.0318
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.0952 0.1251
Schistosoma mansoni RAR-like nuclear receptor 0.0183 0.2312 0.2312
Onchocerca volvulus 0.0066 0.066 0.0978
Echinococcus multilocularis Mastin 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.056 0.7605 0.7605
Toxoplasma gondii thioredoxin reductase 0.0049 0.0433 0.2815
Echinococcus multilocularis FTZ F1 alpha 0.0183 0.2312 0.2312
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Onchocerca volvulus Netrin receptor homolog 0.0033 0.0196 0.0257
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0125 0.0175
Onchocerca volvulus 0.0029 0.0148 0.0183
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0115 0.0698
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0433 0.2831
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Brugia malayi cytochrome P450 0.0027 0.0115 0.0162
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Schistosoma mansoni hypothetical protein 0.0075 0.079 0.079
Brugia malayi intermediate filament protein 0.0029 0.0148 0.0207
Brugia malayi ecdysone receptor 0.0086 0.0952 0.1337
Echinococcus multilocularis musashi 0.0029 0.0148 0.0148
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0316 0.2095
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0183 0.2312 0.2312
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0677 0.095
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0042
Onchocerca volvulus 0.0056 0.0531 0.0777
Echinococcus multilocularis lamin 0.0029 0.0148 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0183 0.2312 0.2312
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0183 0.2312 0.3539
Trypanosoma brucei cytochrome P450, putative 0.0066 0.0664 0.9279
Mycobacterium tuberculosis Probable reductase 0.0113 0.1324 0.8812
Brugia malayi hypothetical protein 0.0021 0.003 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0218 0.1043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0183 0.2312 0.3247
Loa Loa (eye worm) TAR-binding protein 0.0132 0.1591 0.2234
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0115 0.0698
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0121 0.0281
Leishmania major cytochrome p450-like protein 0.0027 0.0115 0.0227
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0115 0.0698
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0586 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1324 0.8722
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.1165 1
Brugia malayi nuclear receptor RXR 0.0086 0.0952 0.1337
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0433 0.0608
Leishmania major hypothetical protein, conserved 0.0102 0.1165 1
Echinococcus granulosus importin subunit beta 1 0.0034 0.0218 0.0286
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0525 0.7119 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0183 0.2312 0.3247
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0708 0.5751
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1324 0.8812
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0115 0.1223
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0547 0.7425 0.9764
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1306 0.1718
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0749 0.5411
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0115 0.0227
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1501 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0125 0.0488
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0115 0.1223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0116 0.1371 0.1371
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0354 0.4708 0.6191
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0586 0.0586
Schistosoma mansoni hypothetical protein 0.004 0.0305 0.0305
Brugia malayi bZIP transcription factor family protein 0.0354 0.4708 0.6613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0568 0.0797
Toxoplasma gondii hypothetical protein 0.0066 0.066 0.4686
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.079 0.1039
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0042
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0086 0.0952 0.0952
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1324 0.8812
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0183 0.2312 0.3247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0183 0.2312 0.304
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0115 0.0151
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0183 0.2312 0.2312
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0027 0.5
Brugia malayi Trypsin-like protease protein 5 0.0021 0.003 0.0042
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0586 0.461
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0183 0.2312 0.3247
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0125 0.0764
Echinococcus granulosus Mastin 0.0021 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Brugia malayi Steroid receptor seven-up type 2 0.0183 0.2312 0.3247
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0196 0.0196
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0708 0.5751
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0115 0.0698
Schistosoma mansoni steroid hormone receptor ad4bp 0.0183 0.2312 0.2312
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0183 0.2312 0.304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0183 0.2312 0.304
Schistosoma mansoni thyroid hormone receptor 0.073 1 1
Echinococcus multilocularis tar DNA binding protein 0.0132 0.1591 0.1591
Schistosoma mansoni lamin 0.0029 0.0148 0.0148
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0091 0.0127
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0066 0.066 0.4686
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0586 0.4073
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0097 0.1097 0.1443
Brugia malayi follicle stimulating hormone receptor 0.0525 0.7119 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0121 0.0826
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0115 0.1223
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0115 0.1223
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0183 0.2312 0.3247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0125 0.007
Brugia malayi Protein kinase domain containing protein 0.0033 0.0203 0.0285
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0115 0.0698
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0115 0.0698
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0316 0.4004
Schistosoma mansoni retinoic acid receptor RXR 0.0183 0.2312 0.2312
Toxoplasma gondii microneme protein MIC17B 0.0066 0.066 0.4686
Onchocerca volvulus 0.0066 0.066 0.0978
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0183 0.2312 0.3247
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1591 0.1591
Leishmania major cytochrome p450-like protein 0.0066 0.0664 0.5336
Onchocerca volvulus 0.0086 0.0952 0.143
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0125 0.0318
Echinococcus granulosus lamin 0.0029 0.0148 0.0194
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Schistosoma mansoni ran 0.0025 0.0091 0.0091
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0586 0.461
Brugia malayi TAR-binding protein 0.0132 0.1591 0.2234
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0086 0.0952 0.0952
Loa Loa (eye worm) hypothetical protein 0.0027 0.0121 0.017
Schistosoma mansoni thyroid hormone receptor 0.073 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0086 0.0952 0.1337
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1591 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0183 0.2312 0.3247
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0183 0.2312 0.2312
Leishmania major cytochrome p450-like protein 0.0027 0.0115 0.0227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0749 0.6124
Brugia malayi RNA binding protein 0.0132 0.1591 0.2234
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0196 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1591 0.1591
Onchocerca volvulus 0.0066 0.066 0.0978
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1501 1
Echinococcus granulosus snurportin 1 0.0365 0.4864 0.6396
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0091 0.0119
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0586 0.461
Loa Loa (eye worm) glutathione reductase 0.0049 0.0433 0.0608
Onchocerca volvulus 0.048 0.6478 1
Brugia malayi Nuclear hormone receptor E75 0.0086 0.0952 0.1337
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0183 0.2312 0.304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.2542 0.2542
Brugia malayi nuclear hormone receptor 0.0183 0.2312 0.3247
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.1115 0.1467
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0125 0.1357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0127 0.0726
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.003 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.2542 0.3343
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0115 0.0227
Echinococcus granulosus nuclear factor of activated T cells 5 0.0167 0.2084 0.2741
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0115 0.1223
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0115 0.0698
Toxoplasma gondii exonuclease III APE 0.0041 0.0316 0.1851
Schistosoma mansoni lamin 0.0029 0.0148 0.0148
Echinococcus multilocularis jun protein 0.0354 0.4708 0.4708
Echinococcus multilocularis snurportin 1 0.0365 0.4864 0.4864
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0316 0.5
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0115 0.1223
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.1115 0.1115
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0316 0.1851
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0115 0.0698
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0115 0.0698
Loa Loa (eye worm) hypothetical protein 0.048 0.6478 0.9099
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0086 0.0952 0.0952
Loa Loa (eye worm) TK/ROR protein kinase 0.0102 0.1165 0.1636
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0183 0.2312 0.3247
Brugia malayi Nuclear hormone receptor-like 1 0.0183 0.2312 0.3247
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Onchocerca volvulus 0.0066 0.066 0.0978
Schistosoma mansoni nuclear receptor 0.0086 0.0952 0.0952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0568 0.0797
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0086 0.0952 0.1337
Loa Loa (eye worm) DR-78 0.0086 0.0952 0.1337
Schistosoma mansoni cytochrome P450 0.0027 0.0115 0.0115
Onchocerca volvulus 0.0029 0.0148 0.0183
Toxoplasma gondii kringle domain-containing protein 0.0102 0.1165 0.8836
Brugia malayi Kringle domain containing protein 0.0102 0.1165 0.1636
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0125 0.0175
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0183 0.2312 0.2312
Echinococcus granulosus tar DNA binding protein 0.0132 0.1591 0.2091
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0102 0.1165 1
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.066 0.0928
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1324 0.8812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0749 1
Leishmania major trypanothione reductase 0.0049 0.0433 0.3186
Echinococcus granulosus jun protein 0.0354 0.4708 0.6191
Loa Loa (eye worm) hypothetical protein 0.048 0.6478 0.9099
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0115 0.1223
Toxoplasma gondii microneme protein MIC17C 0.0066 0.066 0.4686
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0316 0.0444
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1591 0.1591
Brugia malayi steroid hormone receptor 0.0183 0.2312 0.3247
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0316 0.5
Entamoeba histolytica hypothetical protein 0.0028 0.0127 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0316 0.4545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0183 0.2312 0.3247
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0586 0.8017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0749 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0568 0.0797
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0097 0.1097 0.1097
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1306 0.1306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0316 0.2539
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.079 0.079
Onchocerca volvulus 0.0183 0.2312 0.3539
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.0952 0.143
Echinococcus multilocularis Protein lozenge 0.006 0.0583 0.0583
Echinococcus granulosus Ankyrin 0.0033 0.0199 0.0262
Entamoeba histolytica hypothetical protein 0.0075 0.079 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0952 0.1251
Brugia malayi Trypsin family protein 0.0021 0.003 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1501 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0097 0.1097 0.1097
Onchocerca volvulus 0.0278 0.3641 0.56
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0125 0.1357
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0127 0.0335
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Onchocerca volvulus 0.0095 0.1078 0.1625
Trypanosoma brucei trypanothione reductase 0.0049 0.0433 0.554
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Echinococcus granulosus death domain containing protein 0.0033 0.0196 0.0257
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Echinococcus multilocularis enteropeptidase 0.0021 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0066 0.0664 0.0933
Toxoplasma gondii hypothetical protein 0.0066 0.066 0.4686
Echinococcus multilocularis tumor protein p63 0.0386 0.516 0.516
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0115 0.1223
Loa Loa (eye worm) hypothetical protein 0.0033 0.0196 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0115 0.0698
Loa Loa (eye worm) hypothetical protein 0.0056 0.0531 0.0746
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0749 0.4949
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0354 0.4708 0.4708
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0183 0.2312 0.304
Mycobacterium ulcerans hypothetical protein 0.0021 0.003 0.0042
Loa Loa (eye worm) runx1 0.006 0.0583 0.0819
Brugia malayi hypothetical protein 0.0086 0.0952 0.1337
Echinococcus multilocularis 0.0027 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0183 0.2312 0.3247
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0316 0.2539
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0316 0.2045
Echinococcus granulosus ecdysone induced protein 78C 0.0183 0.2312 0.304
Brugia malayi conserved hypotetical protein 0.0086 0.0952 0.1337
Brugia malayi ecdysteroid receptor 0.0183 0.2312 0.3247
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0115 0.0698
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.003 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0125 0.1357
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.079 0.079
Toxoplasma gondii microneme protein MIC4 0.0066 0.066 0.4686
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0749 0.0984
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0708 0.8836
Onchocerca volvulus 0.0066 0.066 0.0978
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0196 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0115 0.0698
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0115 0.1223
Loa Loa (eye worm) trypsin family protein 0.0021 0.003 0.0042
Echinococcus granulosus tissue type plasminogen activator 0.0102 0.1165 0.1532
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1591 0.1591
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.0952 0.143
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0708 0.0708
Toxoplasma gondii microneme protein MIC17A 0.0066 0.066 0.4686
Schistosoma mansoni hypothetical protein 0.0102 0.1165 0.1165
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0365 0.4864 0.6832
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.066 0.0928
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0115 0.1223
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0183 0.2312 0.2312
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0183 0.2312 0.2312
Brugia malayi Cytochrome P450 family protein 0.0066 0.0664 0.0933
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0115 0.0698
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.003 0.0039
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0086 0.0952 0.0952
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0121 0.0826
Brugia malayi Trypsin family protein 0.0021 0.003 0.0042
Echinococcus granulosus intermediate filament protein 0.0029 0.0148 0.0194
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0196 0.0257
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0586 0.077
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0125 0.0175
Echinococcus granulosus transcription factor Dp 1 0.004 0.0299 0.0394
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0175
Brugia malayi nuclear receptor NHR-67 0.0086 0.0952 0.1337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0183 0.2312 0.3247
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0091 0.0561
Schistosoma mansoni hypothetical protein 0.0287 0.3777 0.3777
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.003 0.003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0086 0.0952 0.1251
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0115 0.0698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.2542 0.2542
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0316 0.4545
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0115 0.1223
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0196 0.0275
Loa Loa (eye worm) hypothetical protein 0.0116 0.1371 0.1925
Brugia malayi Protein kinase domain containing protein 0.0102 0.1165 0.1636
Brugia malayi Cytochrome P450 family protein 0.0027 0.0115 0.0162
Loa Loa (eye worm) hypothetical protein 0.0097 0.1097 0.1541
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.1306 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0433 0.0433
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0183 0.2312 0.2312
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0586 0.461
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0115 0.0395
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0115 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0183 0.2312 0.3247
Brugia malayi hypothetical protein 0.0097 0.1097 0.1541
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0042
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0115 0.1223
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0115 0.0698
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0586 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.0952 0.0952
Schistosoma mansoni jun-related protein 0.0287 0.3777 0.3777
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.1591 0.2234
Loa Loa (eye worm) hypothetical protein 0.0086 0.0952 0.1337
Brugia malayi nuclear receptor NHR-88 0.0183 0.2312 0.3247
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0586 0.4073
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.1591 0.2234
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0183 0.2312 0.2312
Entamoeba histolytica hypothetical protein 0.0075 0.079 1
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0305 0.0428
Loa Loa (eye worm) hypothetical protein 0.0066 0.066 0.0928
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0664 0.0933
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0664 0.5336
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0091 0.0561
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0125 0.0488
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.0952 0.1251
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0664 0.0933
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0218 0.0218
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1324 0.8812
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0586 0.0823
Mycobacterium ulcerans hypothetical protein 0.0028 0.0125 0.1357
Schistosoma mansoni hypothetical protein 0.0027 0.0115 0.0115
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0586 0.077
Plasmodium falciparum importin beta, putative 0.0034 0.0218 0.1675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0183 0.2312 0.3247
Brugia malayi hypothetical protein 0.0086 0.0952 0.1337
Brugia malayi hypothetical protein 0.0075 0.079 0.1109
Plasmodium falciparum glutathione reductase 0.0049 0.0433 0.3568
Brugia malayi nuclear receptor NHR-88 0.0086 0.0952 0.1337
Schistosoma mansoni hypothetical protein 0.0365 0.4864 0.4864
Plasmodium vivax importin-beta 2, putative 0.0034 0.0218 0.1675
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Onchocerca volvulus 0.0066 0.066 0.0978
Onchocerca volvulus 0.0066 0.066 0.0978
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.003 0.003
Brugia malayi PAN domain containing protein 0.0066 0.066 0.0928
Loa Loa (eye worm) hypothetical protein 0.0028 0.0125 0.0175
Loa Loa (eye worm) hypothetical protein 0.0102 0.1165 0.1636
Brugia malayi Trypsin family protein 0.0116 0.1371 0.1925
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0196 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0586 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0316 0.3219
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0125 0.0764
Plasmodium falciparum thioredoxin reductase 0.0049 0.0433 0.3568
Leishmania major hypothetical protein, conserved 0.0027 0.0121 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0183 0.2312 0.3247
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0586 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.003 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0183 0.2312 0.3539
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0125 0.007
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0183 0.2312 0.3247
Onchocerca volvulus 0.0066 0.066 0.0978
Entamoeba histolytica hypothetical protein 0.0075 0.079 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0183 0.2312 0.3247
Brugia malayi Importin beta-1 subunit 0.0034 0.0218 0.0306
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0586 0.0586
Echinococcus multilocularis lamin dm0 0.0029 0.0148 0.0148
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0059 0.0568 0.0797
Schistosoma mansoni intermediate filament proteins 0.0029 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0038
Toxoplasma gondii PAN domain-containing protein 0.0066 0.066 0.4686
Loa Loa (eye worm) RNA binding protein 0.0132 0.1591 0.2234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.2542 0.2542
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1324 0.8812
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0125 0.1357
Toxoplasma gondii microneme protein, putative 0.0066 0.066 0.4686
Onchocerca volvulus 0.0116 0.1371 0.2079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 uM Inhibition of guinea pig macrophage Phosphodiesterase 4 ChEMBL. 9871649
IC50 (binding) = 1.2 uM Inhibition of guinea pig macrophage Phosphodiesterase 4 ChEMBL. 9871649
Ki (binding) > 3.7 uM Displacement of [3H]-rolipram binding to guinea pig brain membrane ChEMBL. 9871649
Ki (binding) > 3.7 uM Displacement of [3H]-rolipram binding to guinea pig brain membrane ChEMBL. 9871649

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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