Detailed information for compound 73815

Basic information

Technical information
  • TDR Targets ID: 73815
  • Name: 1,3-dipropyl-8-(3-noradamantyl)xanthine
  • MW: 356.462 | Formula: C20H28N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3
  • InChi: 1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)
  • InChiKey: PJBFVWGQFLYWCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 136199-02-5
  • HMR-4902
  • KW-3902
  • MK-7418
  • Rolofylline
  • 1,3-Dnax
  • 1H-Purine-2,6-dione, 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-
  • 8-(3-Noradamantyl)-1,3-dipropylxanthine
  • 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
  • 8-(Noradamantan-3-yl)-1,3-dipropylxanthine
  • KW 3902

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 22 (organic anion transporter), member 6 Starlite/ChEMBL References
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References
Cavia porcellus Adenosine A2a receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Cavia porcellus Adenosine A1 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References
Mus musculus adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens solute carrier family 22 (organic anion transporter), member 8 Starlite/ChEMBL References
Rattus norvegicus Adenosine A2 receptor Starlite/ChEMBL References
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2b receptor References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Solute carrier family 22 5 Get druggable targets OG5_142702 All targets in OG5_142702
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Adenosine A2a receptor   409 aa 355 aa 20.6 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Brugia malayi major facilitator superfamily protein solute carrier family 22 (organic anion transporter), member 8 542 aa 523 aa 30.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Brugia malayi major facilitator superfamily protein solute carrier family 22 (organic anion transporter), member 6 563 aa 539 aa 30.6 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0074 0.0418 0.1154
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni opsin-like receptor 0.0062 0.0338 0.0373
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0412 0.1683
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0722 0.297
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0168
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0147 0.0773
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Loa Loa (eye worm) norepinephrine transporter 0.0092 0.0548 0.2251
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0659 0.1817
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0124 0.0771 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Echinococcus multilocularis peptidase Clp (S14 family) 0.0045 0.0212 0.0222
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus Protein Wnt-04 0.0016 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0045 0.0212 0.0234
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0418 0.2196
Echinococcus granulosus allatostatin A receptor 0.0062 0.0338 0.0338
Onchocerca volvulus 0.0108 0.0659 0.444
Brugia malayi neuropeptide F receptor 0.0062 0.0338 0.0933
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0338 0.1378
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0307 0.0339
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0338 0.0338
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0418 0.2154
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0221 0.0609
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0023 0.0062 0.1637
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.0338 0.0373
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0007 0.0037
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0037
Brugia malayi ecdysone receptor 0.0022 0.0049 0.0135
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0087 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0323 0.7732
Schistosoma mansoni peptidase Clp (S14 family) 0.0068 0.0378 0.0417
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Echinococcus granulosus serotonin receptor 0.0062 0.0338 0.0338
Brugia malayi RE15519p 0.0062 0.0338 0.0933
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Brugia malayi Dopamine receptor protein 2 0.0062 0.0338 0.0933
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0659 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0338 0.0338
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0221 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0412 0.0454
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus granulosus nAChR subunit 0.0058 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0108 0.0661 0.2719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.1941 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0118 0.0462
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0659 0.2037
Onchocerca volvulus 0.0108 0.0659 0.444
Echinococcus granulosus orexin receptor type 2 0.0062 0.0338 0.0338
Onchocerca volvulus 0.005 0.0248 0.1642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0221 0.0609
Brugia malayi CXXC zinc finger family protein 0.0031 0.0118 0.0324
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor 0.0062 0.0338 0.0338
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.0338 0.0338
Schistosoma mansoni acetylcholine receptor subunit beta 0.005 0.0248 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0178 0.0935
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0099 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0244 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0221 0.089
Brugia malayi G-protein coupled receptor 0.0062 0.0338 0.0933
Loa Loa (eye worm) acetylcholine receptor protein 0.005 0.0248 0.1002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.0156
Onchocerca volvulus 0.0062 0.0338 0.2258
Brugia malayi wnt family protein 0.0016 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.0062 0.0338 0.0373
Treponema pallidum sodium- and chloride- dependent transporter 0.0092 0.0548 0.2825
Brugia malayi Serotonin receptor 0.0062 0.0338 0.0933
Brugia malayi Wnt-2 protein precursor 0.0016 0.0006 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0338 0.0354
Schistosoma mansoni nuclear receptor 0.0022 0.0049 0.0054
Echinococcus granulosus p2X purinoceptor 4 0.0638 0.4415 0.4415
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0099 0.0109
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0221 0.0231
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0108 0.0659 0.2709
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0108 0.0659 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.0338 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Echinococcus granulosus nAChR subunit 0.0108 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0254
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0244 0.0244
Schistosoma mansoni wnt related 0.0016 0.0006 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0895 0.2768
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.0338 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0659 0.0659
Echinococcus multilocularis wnt family member wnt11 2 0.0016 0.0006 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0418 0.2196
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0067 0.0067
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0221 0.0244
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0045 0.0212 0.18
Echinococcus granulosus zinc finger transcription factor gli2 0.0356 0.2414 0.2414
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0418 0.4276
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0108 0.0659 0.2709
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0197 0.0608
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0221 0.0244
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0661 0.3381
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0338 0.0338
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0099 0.0104
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0028
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.005 0.0248 0.0248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0131
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0895 0.9388
Schistosoma mansoni neuropeptide receptor 0.0062 0.0338 0.0373
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.0062 0.0338 0.0373
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0156
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0248 0.0259
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0108 0.0659 0.0659
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.0026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.0338 0.0354
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0068 0.0378 0.0395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0997 0.275
Trypanosoma brucei DNA polymerase beta thumb, putative 0.004 0.0178 0.0935
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0221 0.0244
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0283 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Trypanosoma brucei trypanothione reductase 0.0042 0.0197 0.1033
Brugia malayi hypothetical protein 0.0022 0.0049 0.0135
Echinococcus multilocularis orexin receptor type 2 0.0062 0.0338 0.0354
Onchocerca volvulus 0.0062 0.0338 0.2258
Loa Loa (eye worm) serotonin transporter b 0.0092 0.0548 0.2251
Onchocerca volvulus 0.0062 0.0338 0.2258
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni P2X receptor subunit 0.0638 0.4415 0.4873
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0007 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0156
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0007 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0412 0.0454
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0338 0.1378
Plasmodium vivax SET domain protein, putative 0.0029 0.0099 0.2369
Echinococcus granulosus Protein Wnt-5 0.0016 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Mycobacterium tuberculosis Conserved hypothetical protein 0.0149 0.0953 0.2949
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0067 0.0186
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0221 0.0244
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0147 0.0154
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0108 0.0659 0.0689
Echinococcus multilocularis serotonin receptor 0.018 0.1173 0.1228
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.0338 0.0373
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0045 0.0212 0.0655
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0025 0.0662
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0056 0.029 0.0303
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0221 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0067 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.0989 0.1035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Echinococcus granulosus expressed conserved protein 0.0101 0.0615 0.0615
Echinococcus granulosus microtubule associated protein 2 0.1294 0.906 0.906
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0068 0.0378 0.904
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0092 0.0548 0.2251
Schistosoma mansoni biogenic amine (5HT) receptor 0.018 0.1173 0.1295
Mycobacterium tuberculosis Conserved protein 0.0074 0.0418 0.1293
Echinococcus granulosus sex peptide receptor 0.0062 0.0338 0.0338
Onchocerca volvulus 0.0058 0.0307 0.2044
Brugia malayi ORL1-like opioid receptor 0.0062 0.0338 0.0933
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0197 0.4703
Schistosoma mansoni amine GPCR 0.0062 0.0338 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0545 0.0602
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Schistosoma mansoni cpg binding protein 0.0033 0.013 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.0338 0.0338
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0178 0.0935
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0338 0.0338
Echinococcus granulosus p2X purinoceptor 4 0.0638 0.4415 0.4415
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0149 0.0953 0.0997
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0418 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0418 0.1293
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0221 0.1458
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0108 0.0659 0.0659
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0418 0.2154
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0545 0.0602
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0659 0.2709
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0307 0.0846
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.1284 0.5306
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0131
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0659 0.0659
Echinococcus granulosus Protein Wnt-111 0.0016 0.0006 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0338 0.0354
Brugia malayi neuropeptide F receptor 0.0062 0.0338 0.0933
Brugia malayi hypothetical protein 0.0112 0.069 0.1905
Leishmania major mitochondrial DNA polymerase beta 0.0283 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Schistosoma mansoni hypothetical protein 0.0049 0.0244 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0254
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.0338 0.0933
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0108 0.0659 0.1817
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Entamoeba histolytica hypothetical protein 0.0112 0.069 0.3532
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.0338 0.0933
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0418 0.1293
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0582 0.6245
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0418 0.2196
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0016 0.0007 0.0173
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0108 0.0659 0.2709
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0099 0.0099
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.0338 0.0373
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0134 0.0846 0.4444
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0659 0.0659
Onchocerca volvulus 0.0016 0.0007 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0545 0.0571
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0221 0.0231
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0338 0.0373
Echinococcus multilocularis allatostatin A receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.0338 0.1378
Brugia malayi hypothetical protein 0.0024 0.0067 0.0186
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni hypothetical protein 0.0049 0.0244 0.0269
Schistosoma mansoni wnt related 0.0016 0.0006 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0007 0.0156
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0007 0.0003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0338 0.0373
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.0338 0.0338
Onchocerca volvulus 0.0108 0.0659 0.444
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Brugia malayi excitatory GABA receptor EXP-1A 0.0108 0.0659 0.1817
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0147 0.3895
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Onchocerca volvulus Phospholipase A2 homolog 0.0117 0.0728 0.4909
Plasmodium vivax glutathione reductase, putative 0.0042 0.0197 0.4703
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.0338 0.0933
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0221 0.089
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0283 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0728 0.2995
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0722 0.297
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0068 0.0378 0.904
Toxoplasma gondii hypothetical protein 0.0023 0.0062 0.148
Echinococcus granulosus p2X purinoceptor 4 0.0638 0.4415 0.4415
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0058 0.0307 0.0846
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0221 0.0231
Brugia malayi isocitrate dehydrogenase 0.0036 0.0147 0.0406
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0221 0.0244
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0221 0.1458
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0659 0.1817
Brugia malayi G-protein coupled receptor 0.0062 0.0338 0.0933
Plasmodium falciparum transporter, putative 0.0016 0.0007 0.0173
Onchocerca volvulus 0.0016 0.0007 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0545 0.0571
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0007 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0078
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0007 0.0003
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0108 0.0659 0.0689
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.0338 0.2258
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus multilocularis p2X purinoceptor 4 0.0638 0.4415 0.462
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0147 0.0147
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0338 0.0354
Echinococcus granulosus Protein Wnt-11b 0.0016 0.0006 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0221 0.0609
Brugia malayi Phospholipase A2 family protein 0.0117 0.0728 0.2008
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0338 0.0338
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0307 0.0846
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0067 0.0071
Schistosoma mansoni amine GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0545 0.2238
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.0338 0.0373
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0025 0.0263
Echinococcus granulosus neuropeptide s receptor 0.0062 0.0338 0.0338
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0099 0.0104
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0067 0.0254
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0659 0.0659
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0997 0.275
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0023 0.0062 0.148
Brugia malayi Steroid receptor seven-up type 2 0.0149 0.0953 0.2629
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0049 0.0051
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0108 0.0659 0.1817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.0155 0.0997 0.4112
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0248 0.0683
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Schistosoma mansoni hypothetical protein 0.0049 0.0244 0.0269
Echinococcus granulosus fmrfamide receptor 0.0062 0.0338 0.0338
Brugia malayi conserved hypotetical protein 0.0022 0.0049 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Schistosoma mansoni P2X receptor subunit 0.0638 0.4415 0.4873
Onchocerca volvulus 0.0029 0.0099 0.063
Echinococcus multilocularis wingless type MMTV integration site family 0.0016 0.0006 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.1294 0.906 0.9479
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0221 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.0338 0.0338
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0037
Schistosoma mansoni opsin-like receptor 0.0062 0.0338 0.0373
Brugia malayi Dopamine receptor protein 1 0.0062 0.0338 0.0933
Onchocerca volvulus 0.0074 0.0418 0.2802
Schistosoma mansoni hypothetical protein 0.0388 0.2646 0.2921
Brugia malayi hypothetical protein 0.0016 0.0007 0.0018
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0895 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0244 0.0255
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.032 0.168
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.0989 0.0989
Brugia malayi Cation transporter family protein 0.0108 0.0659 0.1817
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0049 0.0135
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0049 0.0135
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0338 0.0373
Loa Loa (eye worm) zinc finger protein 0.0356 0.2414 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0067 0.0074
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.0846 0.4444
Schistosoma mansoni coup transcription factor 0.0046 0.0221 0.0244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0049 0.0289
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0045 0.0212 0.0655
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0582 0.18
Brugia malayi Serotonin receptor 0.0526 0.3624 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.005 0.0248 0.0259
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.069 0.0762
Echinococcus granulosus g protein coupled receptor 0.0062 0.0338 0.0338
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Onchocerca volvulus 0.0108 0.0659 0.444
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0221 0.0221
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0108 0.0659 0.0659
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0248 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Plasmodium falciparum thioredoxin reductase 0.0042 0.0197 0.5202
Loa Loa (eye worm) hypothetical protein 0.018 0.1173 0.4847
Echinococcus multilocularis p2X purinoceptor 4 0.0638 0.4415 0.462
Loa Loa (eye worm) solute carrier family 6 member 4 0.0092 0.0548 0.2251
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.0338 0.0354
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Toxoplasma gondii thioredoxin reductase 0.0042 0.0197 0.4703
Echinococcus multilocularis WNT 0.0016 0.0006 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.1294 0.906 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.005 0.0248 0.1002
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0248 0.0683
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.0599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0418 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0224 0.1155
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.0338 0.0933
Loa Loa (eye worm) hypothetical protein 0.0056 0.029 0.1177
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0254
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.0156
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0049 0.0051
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Toxoplasma gondii cathepsin CPL 0.0016 0.0007 0.0168
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0418 0.0461
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.0338 0.1378
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0221 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0037
Schistosoma mansoni cpg binding protein 0.0033 0.013 0.0144
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.0338 0.0373
Mycobacterium ulcerans beta-lactamase 0.0074 0.0418 0.4386
Echinococcus granulosus peptidase Clp S14 family 0.0045 0.0212 0.0212
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0244 0.0673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0412 0.1136
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Brugia malayi nuclear hormone receptor 0.0022 0.0049 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0049 0.0054
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0338 0.0354
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0129
Onchocerca volvulus 0.0062 0.0338 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0221 0.089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0221 0.089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0338 0.0373
Mycobacterium ulcerans hypothetical protein 0.0149 0.0953 1
Loa Loa (eye worm) GABA receptor subunit 0.0058 0.0307 0.1248
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0129
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0248 0.0273
Onchocerca volvulus 0.0062 0.0338 0.2258
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.0662
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0338 0.0338
Brugia malayi hypothetical protein 0.005 0.0248 0.0683
Loa Loa (eye worm) DR-78 0.0022 0.0049 0.0178
Entamoeba histolytica hypothetical protein 0.0112 0.069 0.3532
Schistosoma mansoni hypothetical protein 0.0112 0.069 0.0762
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0016 0.0007 0.0007
Echinococcus multilocularis protein Wnt 2 0.0016 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0092 0.0548 0.2251
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 0.3965
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0007 0.0037
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0108 0.0659 0.1817
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0307 0.0846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.005 0.0248 0.0683
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Echinococcus multilocularis conserved hypothetical protein 0.1364 0.9558 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0221 0.0231
Schistosoma mansoni adenoreceptor 0.0062 0.0338 0.0373
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.024 0.126
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.0338 0.0338
Loa Loa (eye worm) glutathione reductase 0.0042 0.0197 0.079
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0338 0.1378
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0147 0.0406
Echinococcus multilocularis zinc finger transcription factor gli2 0.0356 0.2414 0.2526
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0248 0.0248
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0338 0.0354
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0197 0.1033
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Mycobacterium tuberculosis Conserved protein 0.0074 0.0418 0.1293
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0418 0.4386
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0659 0.2037
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0338 0.1378
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0221 0.0609
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.0338 0.2258
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0418 0.1154
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0197 0.079
Mycobacterium tuberculosis Probable reductase 0.0097 0.0582 0.18
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0149 0.0953 0.0953
Brugia malayi glutathione reductase 0.0042 0.0197 0.0543
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0283 0.1903 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0799 0.3293
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0025 0.0129
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0418 0.1293
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0049 0.0054
Onchocerca volvulus 0.0022 0.0049 0.0289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0338 0.0373
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0659 0.0659
Brugia malayi sulfakinin receptor protein 0.0062 0.0338 0.0933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0659 0.0689
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0062 0.0338 0.1378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0582 0.18
Loa Loa (eye worm) voltage-gated potassium channel 0.0122 0.0756 0.3115
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0049 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.3233 1
Schistosoma mansoni wnt-5 0.0016 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.018 0.1173 0.4847
Schistosoma mansoni hypothetical protein 0.0062 0.0338 0.0373
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0221 0.0244
Onchocerca volvulus 0.0092 0.0548 0.369
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0412 0.0454
Brugia malayi hypothetical protein 0.0024 0.0067 0.0186
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0068 0.0378 0.3794
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0659 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0221 0.0609
Echinococcus granulosus GPCR family 2 0.0049 0.0244 0.0244
Echinococcus multilocularis serotonin receptor 0.018 0.1173 0.1228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Mycobacterium ulcerans lipase LipD 0.0074 0.0418 0.4386
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0007 0.0186
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0659 0.0689
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Schistosoma mansoni histamine h1 receptor 0.0062 0.0338 0.0373
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Brugia malayi G protein-coupled receptor 0.0062 0.0338 0.0933
Brugia malayi beta-lactamase family protein 0.0074 0.0418 0.1154
Brugia malayi Wnt-4 protein precursor 0.0016 0.0006 0.0017
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.0338 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0007 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0412 0.0431
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0221 0.0231
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.0338 0.0354
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0582 0.18
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Brugia malayi wnt family protein 0.0016 0.0006 0.0017
Mycobacterium tuberculosis Conserved protein 0.0074 0.0418 0.1293
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0659 0.2037
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0661 0.1824
Echinococcus granulosus g-protein coupled receptor 0.0062 0.0338 0.0338
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.032 0.168
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Leishmania major cathepsin L-like protease 0.006 0.032 0.168
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1941 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.0131
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0221 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.0338 0.0338
Echinococcus multilocularis protein dispatched 1 0.0053 0.0271 0.0283
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0007 0.0186
Brugia malayi steroid hormone receptor 0.0046 0.0221 0.0609
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0147 0.3521
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0049 0.0135
Onchocerca volvulus 0.0016 0.0007 0.0003
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0049 0.0051
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0224 0.0905
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0108 0.0659 0.0727
Onchocerca volvulus 0.0022 0.0049 0.0289
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0221 0.0244
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Schistosoma mansoni acetylcholine receptor-related 0.005 0.0248 0.0273
Schistosoma mansoni amine GPCR 0.0062 0.0338 0.0373
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.0338 0.0373
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0338 0.0373
Schistosoma mansoni neuropeptide receptor 0.0062 0.0338 0.0373
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0221 0.089
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0147 0.0773
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0418 0.1293
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0007 0.0186
Brugia malayi CHE-14 protein 0.0046 0.0224 0.0618
Brugia malayi Probable ClpP-like protease 0.0068 0.0378 0.1043
Onchocerca volvulus 0.0016 0.0007 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0178 0.0935
Echinococcus multilocularis somatostatin receptor 0.0062 0.0338 0.0354
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0224 0.0224
Brugia malayi larval opioid receptor 0.0062 0.0338 0.0933
Echinococcus granulosus glycine receptor subunit beta 0.0108 0.0659 0.0659
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0147 0.0585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0147 0.0154
Onchocerca volvulus 0.0058 0.0307 0.2044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0221 0.0244
Onchocerca volvulus 0.0062 0.0338 0.2258
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 0.1947
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0418 0.0418
Brugia malayi GnHR receptor homolog 0.0062 0.0338 0.0933
Loa Loa (eye worm) hypothetical protein 0.0068 0.0378 0.1543
Onchocerca volvulus 0.0016 0.0007 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0018
Brugia malayi Cation transporter family protein 0.0108 0.0659 0.1817
Echinococcus multilocularis expressed conserved protein 0.0101 0.0615 0.0643
Loa Loa (eye worm) hypothetical protein 0.0056 0.029 0.1177
Brugia malayi nuclear receptor NHR-67 0.0022 0.0049 0.0135
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0023 0.0062 0.0319
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0582 0.18
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Brugia malayi beta-lactamase family protein 0.0074 0.0418 0.1154
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0049 0.0289
Schistosoma mansoni neurotransmitter gated ion channel 0.0058 0.0307 0.0339
Schistosoma mansoni wnt related 0.0016 0.0006 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0446 0.3055 0.3055
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0049 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0418 0.4386
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0221 0.1458
Plasmodium vivax amine transporter, putative 0.0016 0.0007 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Brugia malayi nuclear receptor RXR 0.0022 0.0049 0.0135
Brugia malayi MH2 domain containing protein 0.0117 0.0722 0.1991
Onchocerca volvulus 0.0031 0.0118 0.0756
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0092 0.0548 0.1513
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0221 0.0244
Brugia malayi wnt family protein 0.0016 0.0006 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0418 0.2154
Schistosoma mansoni nuclear receptor 0.0022 0.0049 0.0054
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Trichomonas vaginalis set domain proteins, putative 0.0223 0.1475 0.76
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0156
Loa Loa (eye worm) ACC-1 protein 0.0108 0.0659 0.2709
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0056 0.029 0.1177
Brugia malayi TAR-binding protein 0.0073 0.0412 0.1136
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.0338 0.0354
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0338 0.0338
Entamoeba histolytica hypothetical protein 0.0112 0.069 0.3532
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0988
Brugia malayi Melatonin receptor type 1A 0.0062 0.0338 0.0933
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0049 0.0054
Brugia malayi nuclear receptor NHR-88 0.0046 0.0221 0.0609
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0229 0.1203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.005 0.0248 0.0683
Onchocerca volvulus 0.0108 0.0659 0.444
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0661 0.0692
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.0846 0.4444
Loa Loa (eye worm) fibroinase 0.0016 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0221 0.0609
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0221 0.0609
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.0338 0.0354
Echinococcus granulosus somatostatin receptor 0.0062 0.0338 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0221 0.0609
Echinococcus granulosus cathepsin l1 0.0016 0.0007 0.0007
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0108 0.0659 0.0659
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0221 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0108 0.0659 0.0659
Brugia malayi hypothetical protein 0.005 0.0248 0.0683
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0049 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0997 0.4112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0221 0.0609
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0108 0.0659 0.1817
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0221 0.0231
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0418 0.0437
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.005 0.0248 0.0683
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.069 0.069
Schistosoma mansoni zinc finger protein 0.0022 0.0049 0.0054
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Onchocerca volvulus 0.0062 0.0338 0.2258
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.069 0.0722
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0062 0.0338 0.0933
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Toxoplasma gondii hypothetical protein 0.0046 0.022 0.5251
Loa Loa (eye worm) hypothetical protein 0.0106 0.0648 0.2666
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0673 0.0743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Brugia malayi follicle stimulating hormone receptor 0.0062 0.0338 0.0933
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0147 0.0154
Echinococcus multilocularis protein patched 0.0046 0.0224 0.0234
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) LGC-31 protein 0.0108 0.0659 0.2709
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0648 0.1789
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0338 0.0354
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0108 0.0659 0.1817
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Brugia malayi hypothetical protein 0.005 0.0248 0.0683
Entamoeba histolytica hypothetical protein 0.0058 0.0307 0.155
Onchocerca volvulus 0.0062 0.0338 0.2258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0545 0.1505
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0025 0.0093
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.0338 0.0373
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0659 0.7164
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0659 0.0727
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.0338 0.0354
Plasmodium falciparum amino acid transporter, putative 0.0016 0.0007 0.0173
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0248 0.1002
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0338 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0099 0.0109
Loa Loa (eye worm) hypothetical protein 0.0074 0.0418 0.171
Onchocerca volvulus 0.0108 0.0659 0.444
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Onchocerca volvulus 0.0074 0.0418 0.2802
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0147 0.0773
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0254
Onchocerca volvulus 0.0016 0.0007 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0001
Brugia malayi AKH receptor 0.0062 0.0338 0.0933
Brugia malayi ecdysteroid receptor 0.0046 0.0221 0.0609
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0056 0.029 0.029
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0108 0.0659 0.0689
Echinococcus granulosus g protein coupled receptor 0.0062 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0388 0.2646 0.2921
Leishmania major hypothetical protein, conserved 0.0074 0.0418 0.2196
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0037
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.0131
Schistosoma mansoni hypothetical protein 0.0045 0.0212 0.0234
Echinococcus granulosus g protein coupled receptor 0.0062 0.0338 0.0338
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.0338 0.0354
Schistosoma mansoni cpg binding protein 0.0031 0.0118 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.3055 0.3196
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Echinococcus multilocularis nAChR subunit 0.0108 0.0659 0.0689
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0108 0.0659 0.0689
Brugia malayi tailless protein 0.0022 0.0049 0.0135
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0058 0.0307 0.0339
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0221 0.0609
Schistosoma mansoni hypothetical protein 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Echinococcus multilocularis protein Wnt 1 0.0016 0.0006 0.0007
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.005 0.0248 0.0259
Brugia malayi Thioredoxin reductase 0.0042 0.0197 0.0543
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0338 0.0338
Echinococcus multilocularis GPCR, family 2 0.0049 0.0244 0.0255
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0068 0.0378 0.904
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0108 0.0659 0.0727
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0025 0.0129
Toxoplasma gondii ABC1 family protein 0.0074 0.0418 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.0338 0.0373
Onchocerca volvulus Putative nachr subunit 0.0108 0.0659 0.444
Loa Loa (eye worm) hypothetical protein 0.0046 0.0224 0.0905
Onchocerca volvulus 0.0016 0.0007 0.0003
Echinococcus granulosus geminin 0.0388 0.2646 0.2646
Brugia malayi nuclear receptor RXR 0.0024 0.0067 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0124 0.0771 0.2128
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0124 0.0771 0.0851
Leishmania major trypanothione reductase 0.0042 0.0197 0.1033
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.0338 0.0933
Brugia malayi Dopamine receptor 0.0062 0.0338 0.0933
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0418 0.171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0108 0.0659 0.1817
Trichomonas vaginalis esterase, putative 0.0074 0.0418 0.2154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0248 0.0683
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0221 0.0221
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Loa Loa (eye worm) hypothetical protein 0.0117 0.0728 0.2995
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0108 0.0659 0.0727
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 0.3965
Schistosoma mansoni nAChR subunit 0.005 0.0248 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0221 0.0609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0338 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus multilocularis serotonin transporter 0.0092 0.0548 0.0574
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0108 0.0659 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0221 0.089
Echinococcus granulosus glycine receptor subunit alpha 1 0.0108 0.0659 0.0659
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0338 0.0354
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0025 0.0077
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Brugia malayi hypothetical protein 0.0022 0.0049 0.0135
Echinococcus granulosus cpg binding protein 0.0033 0.013 0.013
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.0338 0.0354
Onchocerca volvulus 0.0046 0.0221 0.1458
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0221 0.0609
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.0338 0.0354
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0418 0.2154
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0049 0.0178
Echinococcus granulosus Solute carrier family 22 5 0.125 0.8749 0.8749
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.0338 0.0338
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0338 0.0373
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0108 0.0659 0.2709
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.0338 0.0354
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0244 0.0244
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0062 0.0338 0.0373
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.0338 0.0354
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0108 0.0659 0.2709
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.0338 0.1378
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni hypothetical protein 0.0045 0.0212 0.0234
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.1248
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0338 0.0338
Onchocerca volvulus 0.005 0.0248 0.1642
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.0338 0.0338
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0049 0.0178
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus granulosus serotonin transporter 0.0092 0.0548 0.0548
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0049 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus granulosus protein Wnt 2 0.0016 0.0006 0.0006
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0068 0.0378 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0197 0.0197
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0049 0.0054
Leishmania major cathepsin L-like protease 0.006 0.032 0.168
Loa Loa (eye worm) hypothetical protein 0.0057 0.0298 0.1212
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.0025
Brugia malayi Cation transporter family protein 0.0108 0.0659 0.1817
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Brugia malayi Zinc finger, C2H2 type family protein 0.0356 0.2414 0.6662
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0338 0.0373
Schistosoma mansoni neuropeptide receptor 0.0062 0.0338 0.0373
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0412 0.1683
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Schistosoma mansoni nAChR subunit 0.005 0.0248 0.0273
Brugia malayi hypothetical protein 0.005 0.0248 0.0683
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0338 0.0354
Toxoplasma gondii exonuclease III APE 0.0018 0.0025 0.0599
Onchocerca volvulus 0.0074 0.0418 0.2802
Brugia malayi hypothetical protein 0.005 0.0248 0.0683
Brugia malayi RNA binding protein 0.0073 0.0412 0.1136
Echinococcus multilocularis sex peptide receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.0338 0.1378
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0338 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0221 0.0609
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0221 0.089
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0147 0.0773
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0582 0.18
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Schistosoma mansoni biogenic amine receptor 0.0062 0.0338 0.0373
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.0338 0.0933
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0147 0.0154
Echinococcus multilocularis nAChR subunit 0.0058 0.0307 0.0321
Loa Loa (eye worm) hypothetical protein 0.0092 0.0548 0.2251
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0067 0.0074
Schistosoma mansoni hypothetical protein 0.0045 0.0212 0.0234
Echinococcus granulosus neuropeptide receptor 0.0062 0.0338 0.0338
Schistosoma mansoni patched 1 0.0046 0.0224 0.0247
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.1941 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0418 0.2154
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Schistosoma mansoni myosin xvIII 0.0062 0.0338 0.0373
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0224 0.0234
Plasmodium falciparum glutathione reductase 0.0042 0.0197 0.5202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0545 0.0545
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0108 0.0659 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Loa Loa (eye worm) RNA binding protein 0.0073 0.0412 0.1683
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0244 0.0255
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.0338 0.0338
Onchocerca volvulus 0.005 0.0248 0.1642
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0244 0.0673
Brugia malayi Pre-SET motif family protein 0.0029 0.0099 0.0273
Echinococcus granulosus biogenic amine 5HT receptor 0.018 0.1173 0.1173
Schistosoma mansoni hypothetical protein 0.0062 0.0338 0.0373
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0338 0.0338
Loa Loa (eye worm) nuclear hormone receptor 0.0125 0.0781 0.3217
Mycobacterium ulcerans hypothetical protein 0.0074 0.0418 0.4386
Schistosoma mansoni amine GPCR 0.0062 0.0338 0.0373
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.0338 0.0933
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0412 0.0454
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Onchocerca volvulus 0.0062 0.0338 0.2258
Onchocerca volvulus 0.0223 0.1475 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0224 0.0224
Echinococcus multilocularis p2X purinoceptor 4 0.0638 0.4415 0.462
Loa Loa (eye worm) beta-lactamase 0.0074 0.0418 0.171
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0108 0.0659 0.1817
Schistosoma mansoni hypothetical protein 0.0446 0.3055 0.3372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0221 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0418 0.1293
Brugia malayi hypothetical protein 0.0062 0.0338 0.0933
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0338 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0099 0.0109
Leishmania major cathepsin L-like protease 0.006 0.032 0.168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.0338 0.0373
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0049 0.0051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0099 0.2369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0545 0.0545
Schistosoma mansoni hypothetical protein 0.0106 0.0648 0.0716
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.032 0.168
Brugia malayi wnt family protein 0.0016 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Onchocerca volvulus 0.0062 0.0338 0.2258
Schistosoma mansoni hypothetical protein 0.0049 0.0244 0.0269
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0338 0.0354
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0028
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0338 0.0354
Echinococcus multilocularis cpg binding protein 0.0033 0.013 0.0136
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0147 0.3521
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0221 0.0609
Schistosoma mansoni biogenic amine receptor 0.0062 0.0338 0.0373
Schistosoma mansoni amine GPCR 0.0062 0.0338 0.0373
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0168
Brugia malayi putative neuropeptide receptor 0.0062 0.0338 0.0933
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0283 0.1903 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.1941 1
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.0338 0.1378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0545 0.0602
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.0108 0.0659 0.0727
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0108 0.0659 0.1817
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0197 0.0206
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.0338 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0221 0.089
Schistosoma mansoni neuropeptide receptor 0.0062 0.0338 0.0373
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0108 0.0659 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0036
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0147 0.0773
Schistosoma mansoni wnt related 0.0016 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0178
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0147 0.3521
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0418 0.1293
Mycobacterium leprae Probable lipase LipE 0.0074 0.0418 0.4276
Echinococcus multilocularis geminin 0.0388 0.2646 0.2769
Brugia malayi nuclear receptor NHR-88 0.0022 0.0049 0.0135
Brugia malayi Pre-SET motif family protein 0.0196 0.1284 0.3543
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0069
Onchocerca volvulus 0.0062 0.0338 0.2258
Onchocerca volvulus 0.0062 0.0338 0.2258
Echinococcus granulosus protein Wnt 1 0.0016 0.0006 0.0006
Echinococcus multilocularis glycine receptor subunit beta 0.0108 0.0659 0.0689
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0124 0.0771 0.0771
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0373 0.0412
Loa Loa (eye worm) hypothetical protein 0.005 0.0248 0.1002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0092 0.0548 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0147 0.0154
Schistosoma mansoni P2X receptor subunit 0.0638 0.4415 0.4873
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0221 0.0221
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0007 0.0018
Loa Loa (eye worm) ctsf protein 0.0016 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0221 0.089
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0037
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0385
Schistosoma mansoni sodium/chloride dependent transporter 0.0092 0.0548 0.0605
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0068 0.0378 0.0378
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0108 0.0659 0.2709
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0221 0.0609
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0147 0.0162
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0108 0.0659 0.0689
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.0338 0.0354
Loa Loa (eye worm) hypothetical protein 0.0108 0.0659 0.2709
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Schistosoma mansoni biogenic amine receptor 0.0062 0.0338 0.0373
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0108 0.0659 0.1817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.1941 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.032 0.168
Brugia malayi nuclear hormone receptor 0.0046 0.0221 0.0609
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0108 0.0659 0.0727
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0412 0.0454
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0147 0.0455
Echinococcus granulosus tar DNA binding protein 0.0073 0.0412 0.0412
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0418 0.1293
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.032 0.168
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0049 0.0054
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.1378
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0049 0.0135
Schistosoma mansoni P2X receptor subunit 0.0638 0.4415 0.4873
Echinococcus multilocularis WNT 0.0016 0.0006 0.0007
Onchocerca volvulus Phospholipase A2 homolog 0.0117 0.0728 0.4909
Entamoeba histolytica hypothetical protein 0.0112 0.069 0.3532

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) TP_TRANSPORTER: inhibition of PGF2alpha uptake in OAT2-expressing S2 cells ChEMBL. 12023506
Cr (functional) = 2 mg dl-1 Serum cretinine concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 2.75+/-0.43) ChEMBL. 1501234
Inhibition (functional) = 46 % Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 123.2+/-14.2) ChEMBL. 1501234
Inhibition (functional) = 47 % Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 2.75+/-0.43) ChEMBL. 1501234
Kd (binding) = 0.00000001138 M The A1-StaR receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
Kd (binding) = 0.000000034815 M The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
Kd (binding) = 0.00000013114666666667 M The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
Ki (binding) = 0.145 nM Binding affinity to mouse adenosine A1 receptor ChEMBL. 20188574
Ki (binding) = 0.19 nM Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]-cyclohexyladenosine ChEMBL. 1501234
Ki (binding) = 0.19 nM Binding affinity at bovine Adenosine A1 receptor. ChEMBL. 12383013
Ki (binding) = 0.19 nM Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]-cyclohexyladenosine ChEMBL. 1501234
Ki (binding) = 0.19 nM Binding affinity at bovine Adenosine A1 receptor. ChEMBL. 12383013
Ki (binding) = 0.19 nM Binding affinity to rat adenosine A1 receptor ChEMBL. 20188574
Ki (binding) = 0.295 nM Binding affinity to human adenosine A1 receptor ChEMBL. 20188574
Ki (binding) = 0.72 nM Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptor ChEMBL. 9191953
Ki (binding) = 0.72 nM Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptor ChEMBL. 9191953
Ki (binding) = 1.1 nM Binding affinity for Adenosine A1 receptor from Guinea pig membranes ChEMBL. 9191953
Ki (binding) = 1.1 nM Binding affinity for Adenosine A1 receptor from Guinea pig membranes ChEMBL. 9191953
Ki (binding) = 1.1 nM Binding affinity to guinea pig adenosine A1 receptor ChEMBL. 20188574
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 1.3 nM Binding affinity towards adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranes ChEMBL. 1404238
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]-PIA as radioligand ChEMBL. 1738138
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosine as radioligand in guinea pig forebrain membranes ChEMBL. 1548682
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]-cyclohexyladenosine as radioligand ChEMBL. 1501234
Ki (binding) = 1.3 nM Binding affinity towards adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranes ChEMBL. 1404238
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]-PIA as radioligand ChEMBL. 1738138
Ki (binding) = 1.3 nM Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosine as radioligand in guinea pig forebrain membranes ChEMBL. 1548682
Ki (binding) = 12.6 nM Binding affinity for Adenosine A1 receptor of rat forebrain ChEMBL. 9191953
Ki (binding) = 12.6 nM Binding affinity for Adenosine A1 receptor of rat forebrain ChEMBL. 9191953
Ki (binding) = 108 nM Inhibition of binding to membranes from HEK-293 cells expressing human Adenosine A2 receptor ChEMBL. 9191953
Ki (binding) = 108 nM Inhibition of binding to membranes from HEK-293 cells expressing human Adenosine A2 receptor ChEMBL. 9191953
Ki (binding) = 170 nM Binding affinity to rat adenosine A2A receptor ChEMBL. 20188574
Ki (binding) = 230 nM Binding affinity for Adenosine A2 receptor from Guinea pig membranes ChEMBL. 9191953
Ki (binding) = 230 nM Binding affinity for Adenosine A2 receptor from Guinea pig membranes ChEMBL. 9191953
Ki (binding) = 230 nM Binding affinity to guinea pig adenosine A2A receptor ChEMBL. 20188574
Ki (binding) = 380 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki (binding) = 380 nM Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. ChEMBL. 1548682
Ki (binding) = 380 nM Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine ChEMBL. 1501234
Ki (binding) = 380 nM Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. ChEMBL. 1548682
Ki (binding) = 430 nM Binding affinity for adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide in guinea pig forebrain membranes ChEMBL. 1404238
Ki (binding) = 430 nM Binding affinity for adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide in guinea pig forebrain membranes ChEMBL. 1404238
Ki (binding) = 510 nM Binding affinity for Adenosine A2 receptor from rat striatal membranes ChEMBL. 9191953
Ki (binding) = 510 nM Binding affinity for Adenosine A2 receptor from rat striatal membranes ChEMBL. 9191953
Ki (functional) = 3.7 uM TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells ChEMBL. 11426832
Ki (functional) = 7.82 uM TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells ChEMBL. 11426832
Ki (functional) = 20.7 uM TP_TRANSPORTER: inhibition of E1S uptake in OAT4-expressing S2 cells ChEMBL. 12023506
Ki ratio (binding) = 290 Ratio of Ki at A2 receptor to that of A1 receptor ChEMBL. 1501234
koff (binding) 1.011 min^-1 Competition binding was performed by incubating membranes (10 ug/well) with 1 K4DD. No reference
kon (binding) = 36150 Ms-1 The A1-StaR receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
kon (binding) = 221020 Ms-1 The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
kon (binding) = 451800 Ms-1 The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
kon (binding) 0.02925 nM^-1 min^-1 Competition binding was performed by incubating membranes (10 ug/well) with 1 K4DD. No reference
k_off (binding) = 0.0004114 s-1 The A1-StaR receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
k_off (binding) = 0.015195 s-1 The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
k_off (binding) = 0.0242033333333333 s-1 The A2A-StaR2 receptor has been purified from membranes in n-decyl-beta-D-maltoside as detergent K4DD. No reference
Na (functional) = 0.256 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.005 mg/kg to rats(potassium and sodium excretion in control rat is 0.160+/-0.006) ChEMBL. 1501234
Na (functional) = 0.258 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.0025 mg/kg to rats(potassium and sodium excretion in control rat is 0.146+/-0.006) ChEMBL. 1501234
Na (functional) = 0.331 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.025 mg/kg to rats(potassium and sodium excretion in control rat is 0.183+/-0.012) ChEMBL. 1501234
Na (functional) = 0.334 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.1 mg/kg to rats(potassium and sodium excretion in control rat is 0.143+/-0.013) ChEMBL. 1501234
Na (functional) = 0.384 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 6.25 mg/kg to rats(potassium and sodium excretion in control rat is 0.146+/-0.005) ChEMBL. 1501234
Na (functional) = 0.399 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 1.6 mg/kg to rats(potassium and sodium excretion in control rat is 0.173+/-0.016) ChEMBL. 1501234
Na (functional) = 0.447 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 0.4 mg/kg to rats(potassium and sodium excretion in control rat is 0.261+/-0.008) ChEMBL. 1501234
Na (functional) = 0.457 m equiv 6hr-1 100g-1 Effect of the compound on urinary excretion potassium and sodium after oral administration of 25 mg/kg to rats(potassium and sodium excretion in control rat is 0.138+/-0.008) ChEMBL. 1501234
Na+/K+ (functional) = 1.11 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.005 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.42 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.45 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.025 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.59 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.0025 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.9 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 1.93 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 2.05 Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 25 mg/Kg ChEMBL. 1501234
Na+/K+ (functional) = 2.07 Ratio of sodium ion/potassium ion concentration in urine of rats following 6.25 mg/kg p.o. ChEMBL. 1501234
Ratio (binding) = 40 Selectivity as ratio of Ki against rat adenosine A2a and A1 receptor binding ChEMBL. 9191953
Ratio (binding) = 150 Selectivity as ratio of Ki against human adenosine A2a and A1 receptor binding ChEMBL. 9191953
Ratio (binding) = 210 Selectivity as ratio of Ki against adenosine A2a and A1 receptor binding in guinea pig ChEMBL. 9191953
Ratio (binding) = 290 Ratio of binding to adenosine A2 and A1 receptors ChEMBL. 1404238
Ratio (binding) = 290 Ratio of A2 to A1. ChEMBL. 1738138
Ratio (binding) = 290 Selectivity is defined as the ratio of Ki(A2 adenosine receptor) / Ki(A1 adenosine receptor) ChEMBL. 1548682
Ratio (binding) = 380 nM Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand ChEMBL. 1738138
Ratio (binding) = 380 nM Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand ChEMBL. 1738138
Solubility = 0.5 ug ml-1 Solubility of the compound(10 mg) was measured in water(2.5 mL) at 20 degree celsius for 1 hr ChEMBL. 1404238
Solubility = 0.6 ug ml-1 Solubility of the compound was measured in saline ChEMBL. 1404238
T/C (functional) = 1.6 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.005 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.69 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.0025 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.7 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.76 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.0025 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.81 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.025 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.83 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.005 mg/Kg ChEMBL. 1501234
T/C (functional) = 1.86 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.13 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.025 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.3 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.34 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.61 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.64 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.65 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.1 mg/Kg ChEMBL. 1501234
T/C (functional) = 2.9 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg ChEMBL. 1501234
T/C (functional) = 3.44 Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg ChEMBL. 1501234
T/C (functional) = 4.15 Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg ChEMBL. 1501234
UN (functional) = 66.4 mg dl-1 Urea nitrogen concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 123.2+/-14.2) ChEMBL. 1501234
Urine volume (functional) = 1.39 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.005 mg/kg to rats(control volume is 0.76+/-0.01) ChEMBL. 1501234
Urine volume (functional) = 1.61 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.0025 mg/kg to rats(control volume is 0.95+/-0.12) ChEMBL. 1501234
Urine volume (functional) = 1.75 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.025 mg/kg to rats(control volume is 0.82+/-0.05) ChEMBL. 1501234
Urine volume (functional) = 2.32 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 6.25 mg/kg to rats(control volume is 0.80+/-0.02) ChEMBL. 1501234
Urine volume (functional) = 2.44 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.1 mg/kg to rats(control volume is 0.92+/-0.05) ChEMBL. 1501234
Urine volume (functional) = 2.64 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 0.4 mg/kg to rats(control volume is 1.4+/-0.05) ChEMBL. 1501234
Urine volume (functional) = 2.74 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 25 mg/kg to rats(control volume is 0.66+/-0.04) ChEMBL. 1501234
Urine volume (functional) = 2.77 ml 6hr-1 100g-1 Oral diuretic activity of the compound was measured after oral administration of 1.6 mg/kg to rats(control volume is 1.06+/-0.02) ChEMBL. 1501234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

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