Detailed information for compound 757493

Basic information

Technical information
  • TDR Targets ID: 757493
  • Name: 2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl )sulfanyl]-N-[3-(trifluoromethyl)phenyl]aceta mide
  • MW: 445.461 | Formula: C21H18F3N5OS
  • H donors: 1 H acceptors: 4 LogP: 4.49 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2ccccc2c2c1nc(SCC(=O)Nc1cccc(c1)C(F)(F)F)nn2
  • InChi: 1S/C21H18F3N5OS/c1-2-10-29-16-9-4-3-8-15(16)18-19(29)26-20(28-27-18)31-12-17(30)25-14-7-5-6-13(11-14)21(22,23)24/h3-9,11H,2,10,12H2,1H3,(H,25,30)
  • InChiKey: LMRVUEMCGHVMTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[(5-propyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]ethanamide
  • AG-205/37081204
  • A1692/0072195

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Schistosoma mansoni tar DNA-binding protein 0.019 0.0709 0.1067
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0388 0.8798
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0004 0.0047
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0324 1
Brugia malayi N-terminal motif family protein 0.0176 0.0653 0.0983
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0099 0.0332 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.0598 0.2074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1862 0.6462
Leishmania major phosphatidylinositol kinase related protein, putative 0.0088 0.0284 0.1013
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0047 0.007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1761 0.6113
Leishmania major phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.1013
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.019 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6268
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0004 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0199 0.0746 0.1123
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0324 0.0488
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0047 0.007
Trichomonas vaginalis set domain proteins, putative 0.0711 0.2881 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0088 0.0284 0.0986
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0065 0.0231
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1614 0.6644 1
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0124 0.3739
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0324 0.0488
Trichomonas vaginalis esterase, putative 0.0035 0.0065 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0004 0.0022
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0004 0.0047
Brugia malayi hypothetical protein 0.0027 0.0029 0.0044
Plasmodium falciparum glutathione reductase 0.0049 0.0124 0.3739
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.0427
Toxoplasma gondii ABC1 family protein 0.0035 0.0065 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Schistosoma mansoni tar DNA-binding protein 0.019 0.0709 0.1067
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0477 0.1906 0.6801
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0324 0.1157
Echinococcus multilocularis expressed conserved protein 0.0092 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.025 0.096 0.3424
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.0578 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.1105 0.1663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0183 0.0276
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.0709 0.2529
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0199 0.0746 0.259
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1614 0.6644 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0294 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1761 0.6113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.1105 0.1105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0123 0.0429 0.0646
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0088 0.0284 0.0284
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0199 0.0746 0.259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.1105 0.1663
Loa Loa (eye worm) hypothetical protein 0.0137 0.0491 0.1751
Loa Loa (eye worm) phosphatidylinositol 3 0.0276 0.1068 0.3811
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0477 0.1906 0.2869
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0135 0.0481 0.2399
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0294 0.0442
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0388 0.4539
Schistosoma mansoni tar DNA-binding protein 0.019 0.0709 0.1067
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0251 0.0964 0.145
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0332 0.1794
Giardia lamblia Hypothetical protein 0.0088 0.0284 0.149
Echinococcus multilocularis Zinc finger, PHD finger 0.0099 0.0332 0.0332
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0123 0.0429 0.149
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0065 0.1389
Mycobacterium leprae conserved hypothetical protein 0.0088 0.0284 0.6413
Brugia malayi RNA recognition motif domain containing protein 0.019 0.0709 0.1067
Brugia malayi Pre-SET motif family protein 0.009 0.0294 0.0442
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0124 0.0187
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0276
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0477 0.1906 0.6801
Loa Loa (eye worm) hypothetical protein 0.025 0.096 0.3424
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0093 0.014
Leishmania major hypothetical protein, conserved 0.0088 0.0284 0.1013
Loa Loa (eye worm) hypothetical protein 0.009 0.0294 0.1048
Mycobacterium leprae Probable lipase LipE 0.0035 0.0065 0.1389
Mycobacterium ulcerans beta-lactamase 0.0035 0.0065 0.1894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0324 0.0488
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1614 0.6644 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0099 0.0332 0.1655
Loa Loa (eye worm) phosphatidylinositol kinase 0.0088 0.0284 0.1013
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.0332 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1862 0.6462
Brugia malayi Thioredoxin reductase 0.0049 0.0124 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6268
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0199 0.0746 0.259
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0004 0.0047
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0065 0.0756
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0063 0.0226
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0124 0.0124
Echinococcus granulosus cpg binding protein 0.003 0.0044 0.0066
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0199 0.0746 0.1123
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0501 0.2005 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0442 0.1761 0.6283
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0004 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Loa Loa (eye worm) cytochrome P450 0.0021 0.0004 0.0014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0477 0.1906 0.2869
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0294 0.0442
Echinococcus granulosus tar DNA binding protein 0.019 0.0709 0.1067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0324 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0756 0.1138
Onchocerca volvulus 0.0035 0.0065 0.0224
Loa Loa (eye worm) hypothetical protein 0.0088 0.0284 0.1013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.1906 0.6617
Onchocerca volvulus 0.009 0.0294 0.1019
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0111 0.0381 0.2
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0441 0.5153
Giardia lamblia GTOR 0.0477 0.1906 1
Schistosoma mansoni tar DNA-binding protein 0.019 0.0709 0.1067
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0653 0.2268
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0064 0.0183 0.0653
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0088 0.0284 0.0427
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0123 0.0429 0.149
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0036 0.0068 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0004 0.0047
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0029 0.088
Loa Loa (eye worm) phosphatidylinositol 3 0.0477 0.1906 0.6801
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0088 0.0284 0.0427
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0294 0.0294
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0388 0.4539
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0004 0.0047
Toxoplasma gondii FATC domain-containing protein 0.0251 0.0964 0.5208
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0047 0.0166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0324 0.1157
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.0964 0.145
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0099 0.0332 0.1152
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0324 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0065 0.0756
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0065 0.1894
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0326 0.0491
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0692 0.2803 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0093 0.0332
Schistosoma mansoni hypothetical protein 0.0346 0.1359 0.2045
Entamoeba histolytica hypothetical protein 0.0088 0.0284 0.1416
Echinococcus granulosus geminin 0.0346 0.1359 0.2045
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0284 0.1013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0429 0.214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0037 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0272 0.1053 0.3654
Loa Loa (eye worm) hypothetical protein 0.0158 0.0578 0.2063
Entamoeba histolytica protein kinase rad3, putative 0.0251 0.0964 0.4805
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0441 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0299 0.1165 0.1754
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0183 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0047 0.0166
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0099 0.0332 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0124 0.3739
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0692 0.2803 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0093 0.0332
Entamoeba histolytica hypothetical protein 0.0036 0.0068 0.0337
Brugia malayi Cytochrome P450 family protein 0.0031 0.0047 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0388 0.4539
Echinococcus multilocularis cpg binding protein 0.003 0.0044 0.0044
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0004 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0068 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0477 0.1906 0.2869
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0111 0.038 0.1896
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0466 0.1862 0.6643
Toxoplasma gondii thioredoxin reductase 0.0049 0.0124 0.0671
Leishmania major phosphatidylinositol 3-kinase, putative 0.0099 0.0332 0.1184
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0285 0.1105 0.3943
Loa Loa (eye worm) hypothetical protein 0.0201 0.0756 0.2697
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0332 0.05
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0756 0.1138
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0047 0.0166
Entamoeba histolytica hypothetical protein 0.0036 0.0068 0.0337
Toxoplasma gondii exonuclease III APE 0.0097 0.0324 0.1752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0275 0.1064 0.3694
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0477 0.1906 0.9506
Mycobacterium tuberculosis Conserved hypothetical protein 0.0088 0.0284 0.3321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0184 0.0277
Echinococcus granulosus serine protein kinase ATM 0.0251 0.0964 0.145
Loa Loa (eye worm) TAR-binding protein 0.019 0.0709 0.2529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0088 0.0284 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.1081 0.3754
Onchocerca volvulus 0.0088 0.0284 0.0986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Schistosoma mansoni hypothetical protein 0.0137 0.0491 0.0739
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0088 0.0284 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0004 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0123 0.0429 0.0646
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0332 0.05
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0088 0.0284 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.0429 0.0646
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0477 0.1906 0.2869
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0093 0.0323
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0065 0.0231
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0326 0.0491
Leishmania major cytochrome p450-like protein 0.0031 0.0047 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0964 0.3345
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0299 0.1165 0.1165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0065 0.1894
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.1008 0.3596
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0065 0.0097
Schistosoma mansoni patched 1 0.0042 0.0093 0.014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0183 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0004 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0088 0.0284 0.1416
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0324 0.9766
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0324 0.3791
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0163 0.0598 0.09
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0004 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0284 0.1013
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0088 0.0284 0.0986
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0326 0.1626
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0183 0.0183
Loa Loa (eye worm) beta-lactamase 0.0035 0.0065 0.0231
Onchocerca volvulus 0.0029 0.0037 0.0129
Schistosoma mansoni cytochrome P450 0.0021 0.0004 0.0006
Echinococcus multilocularis geminin 0.0346 0.1359 0.1359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0284 0.0427
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1862 0.6462
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.0097
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0088 0.0284 0.1013
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0099 0.0332 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0029 0.0044
Brugia malayi Cytochrome P450 family protein 0.0065 0.019 0.0285
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0324 0.1125
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0004 0.0047
Echinococcus multilocularis serine protein kinase ATM 0.0251 0.0964 0.0964
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0299 0.1165 0.1754
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0099 0.0332 0.1184
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0964 0.3345
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.8556
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.0097
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0068 0.0068
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0088 0.0284 0.0427
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0047 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0286 0.1109 0.3849
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0004 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0284 0.0986
Trypanosoma brucei trypanothione reductase 0.0049 0.0124 0.0443
Echinococcus multilocularis protein patched 0.0042 0.0093 0.0093
Brugia malayi beta-lactamase 0.0035 0.0065 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0284 0.0986
Loa Loa (eye worm) hypothetical protein 0.0191 0.0715 0.2553
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0065 0.0756
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0004 0.0047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1614 0.6644 0.6644
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0756
Brugia malayi RNA binding protein 0.019 0.0709 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6268
Echinococcus multilocularis tar DNA binding protein 0.019 0.0709 0.0709
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0756
Leishmania major cytochrome p450-like protein 0.0021 0.0004 0.0014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0477 0.1906 0.2869
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0099 0.0332 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0123 0.0429 0.149
Plasmodium falciparum thioredoxin reductase 0.0049 0.0124 0.3739
Loa Loa (eye worm) RNA binding protein 0.019 0.0709 0.2529
Loa Loa (eye worm) hypothetical protein 0.0176 0.0653 0.2331
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Entamoeba histolytica hypothetical protein 0.0251 0.0964 0.4805
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0163 0.0597 0.2072
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0088 0.0284 0.8556
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0065 0.0756
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.029 0.1126 0.4018
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0088 0.0284 0.0427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0964 0.145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1862 0.6462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.1906 0.6617
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.0224
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0124 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0672 0.2331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0272 0.1053 0.3654
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0131
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0477 0.1906 0.6801
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0101 0.0337 0.0508
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0491 0.0739
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0004 0.0047
Schistosoma mansoni cpg binding protein 0.0029 0.0037 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0199 0.0746 0.1123
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0224
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0324 0.17
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0251 0.0964 0.3438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0294 0.0442
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0231
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0388 0.4539
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0324 0.9766
Loa Loa (eye worm) hypothetical protein 0.0279 0.1081 0.3858
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0251 0.0964 0.145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0183 0.0276
Entamoeba histolytica hypothetical protein 0.0088 0.0284 0.1416
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0099 0.0332 0.05
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0324 0.1616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.1906 0.6617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.2005 0.696
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.0715 0.2483
Trypanosoma cruzi target of rapamycin kinase 3 0.0466 0.1862 0.2802
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0332 0.1794
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.0578 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0099 0.0332 0.1152
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0251 0.0964 0.0964
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0251 0.0964 0.145
Loa Loa (eye worm) hypothetical protein 0.0098 0.0326 0.1164
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0466 0.1862 0.6643
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.1008 0.1517
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0306
Entamoeba histolytica hypothetical protein 0.0175 0.0649 0.3236
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Entamoeba histolytica hypothetical protein 0.0036 0.0068 0.0337
Echinococcus multilocularis GPCR, family 2 0.0064 0.0183 0.0183
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0088 0.0284 0.0284
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0251 0.0964 0.3438
Schistosoma mansoni ap endonuclease 0.0097 0.0324 0.0488
Schistosoma mansoni ap endonuclease 0.0097 0.0324 0.0488
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0004 0.0014
Echinococcus multilocularis 0.0088 0.0284 0.0284
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0756 0.2697
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0099 0.0332 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0633 0.2197
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0294 0.0442
Loa Loa (eye worm) glutathione reductase 0.0049 0.0124 0.0443
Entamoeba histolytica hypothetical protein 0.0036 0.0068 0.0337
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.8556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1182 0.4103
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0004 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0328 0.114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0456 0.1817 0.6307
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0442 0.1761 0.6283
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0324 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.1105 0.1663
Brugia malayi CHE-14 protein 0.0042 0.0093 0.014
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1614 0.6644 1
Brugia malayi Cytochrome P450 family protein 0.0021 0.0004 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0324 0.1157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0285 0.1105 0.1663
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0004 0.0047
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0441 0.5153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.1806 0.6267
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0088 0.0284 0.0427
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0285 0.1105 0.1663
Onchocerca volvulus 0.0088 0.0284 0.0986
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0501 0.0501
Brugia malayi hypothetical protein 0.0036 0.0068 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Onchocerca volvulus 0.0035 0.0065 0.0224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0284 0.0427
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0633 0.2197
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0004 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.1862 0.6462
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0093 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.185 0.6422
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0088 0.0284 0.8556
Entamoeba histolytica hypothetical protein 0.0088 0.0284 0.1416
Brugia malayi Pre-SET motif family protein 0.0625 0.2522 0.3796
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0163 0.0597 0.2072
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0191 0.0715 0.1077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0104
Schistosoma mansoni hypothetical protein 0.0088 0.0284 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0272 0.1053 0.3654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0456 0.1817 0.6307
Schistosoma mansoni hypothetical protein 0.0191 0.0715 0.1077
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0501 0.0754
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0029 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0285 0.1105 0.1105
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0124 0.0187
Echinococcus multilocularis 0.0021 0.0004 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0065 0.0097
Giardia lamblia Phosphatidylinositol 4-kinase 0.0088 0.0284 0.149
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0324 0.1125
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0332 0.05
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0477 0.1906 0.6801
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0756
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0004 0.0047
Echinococcus multilocularis protein dispatched 1 0.0048 0.0118 0.0118
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0099 0.0332 0.05
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0473
Loa Loa (eye worm) phosphatidylinositol 3 0.0692 0.2803 1
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0284 0.8556
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0004 0.0047
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0088 0.0284 0.8556
Schistosoma mansoni cpg binding protein 0.003 0.0044 0.0066
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0068 0.0102
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.014 0.05 0.2621
Echinococcus granulosus expressed conserved protein 0.0092 0.0301 0.0454
Schistosoma mansoni cpg binding protein 0.003 0.0044 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0199 0.0746 0.3721
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0175 0.0649 0.3236
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0855 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0157 0.085
Brugia malayi CXXC zinc finger family protein 0.0029 0.0037 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0029 0.088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.2522 0.8997
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0088 0.0284 0.0427
Leishmania major cytochrome p450-like protein 0.0021 0.0004 0.0014
Mycobacterium ulcerans hypothetical protein 0.0035 0.0065 0.1894
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0477 0.1906 0.1906
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0097
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0109 0.0373 0.1332
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0124 0.1451
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0332 0.1184
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0477 0.1906 0.9506
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.0429 0.214
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0294 0.1587
Echinococcus granulosus GPCR family 2 0.0064 0.0183 0.0276
Plasmodium vivax SET domain protein, putative 0.009 0.0294 0.8848
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0063 0.0095
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0279 0.1081 0.5845
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0065 0.1948
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0065 0.0756
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0088 0.0284 0.0427
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0065 0.0756
Leishmania major hypothetical protein, conserved 0.0035 0.0065 0.0231
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0099 0.0332 0.1184
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0388 0.4539
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0029 0.0104
Schistosoma mansoni fkbp-rapamycin associated protein 0.0251 0.0964 0.145
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0099 0.0332 0.1655
Leishmania major trypanothione reductase 0.0049 0.0124 0.0443
Brugia malayi TAR-binding protein 0.019 0.0709 0.1067
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0284 0.1013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0088 0.0284 0.1535
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.0332 0.05
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0029 0.0158
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0004 0.0047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0277 0.0417
Brugia malayi Cytochrome P450 family protein 0.0031 0.0047 0.007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0441 0.5153
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0088 0.0284 0.0427
Schistosoma mansoni hypothetical protein 0.0346 0.1359 0.2045
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0047 0.1331
Mycobacterium tuberculosis Probable reductase 0.0113 0.0388 0.4539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0285 0.1105 0.1663
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0123 0.0429 0.1531
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0004 0.0014
Mycobacterium ulcerans lipase LipD 0.0035 0.0065 0.1894
Onchocerca volvulus 0.0711 0.2881 1
Leishmania major hypothetical protein, conserved 0.0027 0.0029 0.0104
Leishmania major hypothetical protein, unknown function 0.0088 0.0284 0.1013
Loa Loa (eye worm) hypothetical protein 0.0163 0.0598 0.2132
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0065 0.0756
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0964 0.145
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0284 0.1013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0183 0.0653
Brugia malayi glutathione reductase 0.0049 0.0124 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0158 0.0578 0.087
Toxoplasma gondii target of rapamycin (TOR), putative 0.0464 0.185 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1761 0.6113
Schistosoma mansoni tar DNA-binding protein 0.019 0.0709 0.1067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0294 0.0294
Brugia malayi FAT domain containing protein 0.0191 0.0715 0.1077
Onchocerca volvulus 0.0035 0.0065 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0224
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1614 0.6644 1
Brugia malayi cytochrome P450 0.0021 0.0004 0.0006
Leishmania major phosphatidylinositol kinase, putative 0.0088 0.0284 0.1013
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0672 0.2331
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0284 0.1013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0183 0.0276
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.1008 0.3498
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0097 0.0324 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0088 0.0284 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.1761 0.6113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.2803 0.9728
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0191 0.0715 0.0715
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0088 0.0284 0.1535
Schistosoma mansoni hypothetical protein 0.0064 0.0183 0.0276
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0284 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0029 0.088
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0598 0.2074
Plasmodium vivax hypothetical protein 0.0088 0.0284 0.8556
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0004 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.0224

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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