Detailed information for compound 757890

Basic information

Technical information
  • TDR Targets ID: 757890
  • Name: N-(3-cyanophenyl)-1-(4-methoxyphenyl)-2,5-dio xo-7,8-dihydro-6H-quinoline-3-carboxamide
  • MW: 413.425 | Formula: C24H19N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c2CCCC(=O)c2cc(c1=O)C(=O)Nc1cccc(c1)C#N
  • InChi: 1S/C24H19N3O4/c1-31-18-10-8-17(9-11-18)27-21-6-3-7-22(28)19(21)13-20(24(27)30)23(29)26-16-5-2-4-15(12-16)14-25/h2,4-5,8-13H,3,6-7H2,1H3,(H,26,29)
  • InChiKey: PISWZKKGGBKFAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyanophenyl)-2,5-diketo-1-(4-methoxyphenyl)-7,8-dihydro-6H-quinoline-3-carboxamide
  • ST5027276
  • ZINC00809721
  • BAS 07464507

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0059 0.0304 0.0344
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.049 0.3879 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0232 0.0764
Mycobacterium ulcerans leucyl aminopeptidase 0.0101 0.0653 0.1557
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.0301
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1516 0.1727
Toxoplasma gondii leucyl aminopeptidase LAP 0.0101 0.0653 0.5653
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0304 0.0465
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0667 1
Echinococcus multilocularis Smad4 0.0033 0.0095 0.0146
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0101 0.0653 0.1426
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0689 0.5531 1
Mycobacterium leprae Probable lipase LipE 0.0108 0.0713 0.1714
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0101 0.0653 0.1557
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0176 0.0309
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0304 0.2336
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Schistosoma mansoni cpg binding protein 0.0055 0.0276 0.0369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Brugia malayi MH2 domain containing protein 0.0033 0.0095 0.0107
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1149 0.1993
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0461 0.1765
Brugia malayi MH1 domain containing protein 0.0033 0.0095 0.0107
Onchocerca volvulus 0.0048 0.0213 0.0156
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0149 0.1054 0.1761
Onchocerca volvulus 0.0054 0.0266 0.0209
Entamoeba histolytica acyl-CoA synthetase, putative 0.0043 0.0176 0.0275
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0168 0.028
Brugia malayi MH1 domain containing protein 0.0033 0.0095 0.0107
Brugia malayi hypothetical protein 0.0102 0.0667 0.0759
Echinococcus multilocularis dnaJ subfamily B 0.0744 0.5982 0.9151
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0252 0.0285
Echinococcus multilocularis musashi 0.0054 0.0266 0.0407
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0713 0.0811
Schistosoma mansoni cpg binding protein 0.0055 0.0276 0.0369
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0667 0.2664
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Schistosoma mansoni inositol monophosphatase 0.0036 0.0116 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.0739 0.2981
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0043 0.0176 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0713 0.2866
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.17 0.1937
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0101 0.0653 0.2603
Giardia lamblia DINP protein human, muc B family 0.0111 0.0739 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0189
Leishmania major DNA damage repair protein, putative 0.0033 0.009 0.014
Echinococcus multilocularis cpg binding protein 0.0055 0.0276 0.0423
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0156 0.111 0.1698
Brugia malayi hypothetical protein 0.0066 0.0366 0.0416
Brugia malayi beta-lactamase family protein 0.0108 0.0713 0.0811
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0304 0.0508
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0168 0.028
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0213 0.0325
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0043 0.0176 0.0309
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0232 0.0388
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0356 0.0404
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0474 0.1819
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0105 0.0692 0.1157
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0168 0.0256
Echinococcus multilocularis pyruvate kinase 0.0029 0.0058 0.0089
Schistosoma mansoni transcription factor LCR-F1 0.0299 0.2295 0.3776
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Brugia malayi mbt repeat family protein 0.0048 0.0213 0.0241
Loa Loa (eye worm) MBCTL1 0.0054 0.0267 0.0303
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.049 0.3879 1
Brugia malayi hypothetical protein 0.0299 0.2295 0.2617
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0168 0.0185
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0105 0.0692 0.107
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.049 0.3879 1
Mycobacterium ulcerans hypothetical protein 0.016 0.1149 0.2854
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0418 0.0699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0461 0.0917
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0176 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.108 0.8765 1
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0494 0.0825
Loa Loa (eye worm) hypothetical protein 0.0059 0.0304 0.0344
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0461 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.028 0.0974
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.009 0.014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0461 0.69
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0232 0.0764
Echinococcus multilocularis dna polymerase eta 0.0152 0.1076 0.1646
Echinococcus multilocularis pyruvate kinase 0.0023 0.0008 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0325 0.0451
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0325 0.254
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Echinococcus granulosus L aminoadipate semialdehyde 0.0072 0.0415 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0267 0.0303
Schistosoma mansoni intermediate filament proteins 0.0054 0.0266 0.0351
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Loa Loa (eye worm) hypothetical protein 0.0152 0.1076 0.1225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0168 0.011
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1014 0.4182
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0168 0.048
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0325 0.0451
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0713 0.1197
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Brugia malayi beta-lactamase 0.0108 0.0713 0.0811
Onchocerca volvulus 0.0072 0.0415 0.0359
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0029 0.006 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0032 0.0086 0.0469
Mycobacterium ulcerans lipase LipD 0.0108 0.0713 0.1714
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0095 0.0107
Loa Loa (eye worm) hypothetical protein 0.0156 0.111 0.1265
Onchocerca volvulus 0.0108 0.0713 0.0659
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0461 0.0406
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0304 0.2336
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Echinococcus multilocularis microtubule associated protein 2 0.0658 0.5272 0.8064
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0667 0.5787
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0304 0.0344
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0267 0.0447
Plasmodium vivax pyruvate kinase, putative 0.0029 0.0058 0.049
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Schistosoma mansoni hypothetical protein 0.0707 0.5675 0.9482
Loa Loa (eye worm) hypothetical protein 0.0056 0.028 0.0318
Brugia malayi Pre-SET motif family protein 0.0156 0.111 0.1265
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0032 0.0086 0.0073
Schistosoma mansoni ap endonuclease 0.0078 0.0461 0.0681
Brugia malayi PHD-finger family protein 0.0059 0.0304 0.0344
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.2343 1
Echinococcus granulosus pyruvate kinase 0.0029 0.0058 0.0097
Treponema pallidum licC protein (licC) 0.009 0.0563 1
Mycobacterium ulcerans hypothetical protein 0.009 0.0563 0.1323
Loa Loa (eye worm) inositol-1 0.0036 0.0116 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Mycobacterium ulcerans hypothetical protein 0.0043 0.0176 0.0309
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0105 0.0692 0.0787
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0232 0.0764
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Schistosoma mansoni lamin 0.0054 0.0266 0.0351
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Schistosoma mansoni DNA polymerase eta 0.0152 0.1076 0.1718
Onchocerca volvulus 0.0108 0.0713 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Loa Loa (eye worm) hypothetical protein 0.0077 0.0455 0.0517
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0035 0.0058
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0128 0.0883 0.0829
Loa Loa (eye worm) hypothetical protein 0.01 0.065 0.074
Brugia malayi Fli-1 protein 0.022 0.1639 0.1868
Loa Loa (eye worm) hypothetical protein 0.0065 0.0356 0.0404
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0356 0.0404
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1516 0.1727
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0461 0.0524
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0563 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0035 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0325 0.0488
Brugia malayi MH2 domain containing protein 0.049 0.3878 0.4423
Echinococcus multilocularis smad 0.0033 0.0095 0.0146
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0078 0.0462 0.0525
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.3878 0.4423
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1501 0.2296
Loa Loa (eye worm) hypothetical protein 0.0062 0.0331 0.0376
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0356 0.0595
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.009 0.0779
Echinococcus multilocularis lamin 0.0054 0.0266 0.0407
Brugia malayi follicle stimulating hormone receptor 0.0233 0.175 0.1995
Onchocerca volvulus Alhambra homolog 0.0059 0.0304 0.0247
Schistosoma mansoni hypothetical protein 0.0744 0.5982 1
Brugia malayi Inositol-1 0.0036 0.0116 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0232 0.0764
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1014 0.4182
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0095 0.0159
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.043 0.0629
Echinococcus multilocularis GPCR, family 2 0.0065 0.0356 0.0544
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0406 0.0621
Schistosoma mansoni ap endonuclease 0.0078 0.0461 0.0681
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.17 0.1937
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0168 0.0185
Onchocerca volvulus 0.0043 0.0176 0.0119
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0325 0.0497
Schistosoma mansoni jumonji domain containing protein 0.0152 0.108 0.1726
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Brugia malayi Pre-SET motif family protein 0.108 0.8765 1
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0494 0.0755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0116 0.0784 0.1225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0032 0.0086 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0072 0.0415 0.0634
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0168 0.1611
Trypanosoma brucei unspecified product 0.0073 0.0421 0.1589
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.175 0.1995
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0085 0.0071
Trichomonas vaginalis esterase, putative 0.0108 0.0713 0.0659
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0713 0.641
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1407 0.2152
Brugia malayi Smad1 0.0033 0.0095 0.0107
Loa Loa (eye worm) hypothetical protein 0.0102 0.0667 0.0759
Echinococcus granulosus geminin 0.0707 0.5675 0.9487
Plasmodium falciparum M17 leucyl aminopeptidase 0.0101 0.0653 0.9788
Mycobacterium ulcerans hypothetical protein 0.0033 0.009 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0028
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0232 0.0388
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0232 0.0263
Brugia malayi polk-prov protein 0.0056 0.028 0.0318
Trypanosoma brucei unspecified product 0.0123 0.0835 0.3401
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi DNA polymerase eta, putative 0.0152 0.1076 0.4454
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.049 0.3879 0.6982
Schistosoma mansoni hypothetical protein 0.014 0.0979 0.1555
Echinococcus multilocularis pyruvate kinase 0.0029 0.0058 0.0089
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0713 0.1197
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0095 0.0159
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0116 0.0059
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.0247
Toxoplasma gondii ABC1 family protein 0.0108 0.0713 0.6225
Echinococcus multilocularis peregrin 0.0059 0.0304 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0095 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0043 0.0176 0.0275
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0176 0.0309
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0157 0.0176
Onchocerca volvulus 0.0156 0.111 0.1058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0461 0.1765
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0462 0.0682
Leishmania major hypothetical protein, conserved 0.0108 0.0713 0.2866
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0213 0.0261
Echinococcus multilocularis leucine aminopeptidase protein 0.0101 0.0653 0.0999
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0304 0.0415
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0266 0.0301
Onchocerca volvulus 0.0052 0.0252 0.0195
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0713 0.1714
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.17 0.26
Entamoeba histolytica protein kinase, putative 0.0078 0.0462 0.1587
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0232 0.0764
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0072 0.0415 0.0471
Schistosoma mansoni lamin 0.0054 0.0266 0.0351
Echinococcus granulosus pyruvate kinase 0.0029 0.0058 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.009 0.014
Entamoeba histolytica protein kinase, putative 0.0078 0.0462 0.1587
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Echinococcus granulosus dna polymerase kappa 0.0128 0.0883 0.1475
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0232 0.0764
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0356 0.0544
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0713 0.1714
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0462 0.1587
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0116 0.0178
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Brugia malayi Protein kinase domain containing protein 0.0078 0.0462 0.0525
Loa Loa (eye worm) hypothetical protein 0.0048 0.0213 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Schistosoma mansoni hypothetical protein 0.0059 0.0304 0.0415
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0176 0.0309
Loa Loa (eye worm) Smad1 0.0033 0.0095 0.0107
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0213 0.0356
Echinococcus granulosus Smad4 0.0033 0.0095 0.0159
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0713 0.1197
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0111 0.0739 0.1245
Schistosoma mansoni hypothetical protein 0.0707 0.5675 0.9482
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0218 0.0271
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0095 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0116 0.0059
Leishmania major DNA polymerase eta, putative 0.0152 0.1076 0.4454
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0101 0.0653 0.1087
Onchocerca volvulus 0.0108 0.0713 0.0659
Onchocerca volvulus 0.0048 0.0218 0.0161
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0058 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0156 0.111 0.1856
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.009 0.014
Chlamydia trachomatis cytosol aminopeptidase 0.0101 0.0653 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0232 0.0764
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0213 0.0261
Schistosoma mansoni Smad4 0.0033 0.0095 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.028 0.0974
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0356 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0713 0.1106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.17 0.2841
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.2343 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0116 0.0059
Echinococcus multilocularis tumor protein p63 0.0329 0.2547 0.3896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0461 0.592
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0168 0.0256
Leishmania major hypothetical protein, conserved 0.0102 0.0667 0.2664
Loa Loa (eye worm) hypothetical protein 0.0205 0.1516 0.1727
Echinococcus granulosus dna polymerase eta 0.0152 0.1076 0.1798
Schistosoma mansoni inositol monophosphatase 0.0036 0.0116 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.043 0.0489
Loa Loa (eye worm) hypothetical protein 0.014 0.0979 0.1115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Echinococcus granulosus cpg binding protein 0.0055 0.0276 0.0462
Plasmodium falciparum phd finger protein, putative 0.0059 0.0304 0.4524
Brugia malayi Pyruvate kinase, M2 isozyme 0.0029 0.0058 0.0064
Brugia malayi Ets-domain containing protein 0.0072 0.0418 0.0475
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0213 0.0325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0356 0.0544
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0232 0.0355
Schistosoma mansoni cpg binding protein 0.0052 0.0252 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0095 0.0107
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0713 0.0659
Echinococcus granulosus microtubule associated protein 2 0.0658 0.5272 0.8813
Schistosoma mansoni microtubule-associated protein tau 0.0658 0.5272 0.8801
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0667 0.2664
Onchocerca volvulus 0.0146 0.1028 0.0976
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0105 0.0692 0.1059
Echinococcus granulosus dual specificity 0.0078 0.0462 0.0772
Echinococcus granulosus intermediate filament protein 0.0054 0.0266 0.0444
Echinococcus granulosus smad 0.0033 0.0095 0.0159
Loa Loa (eye worm) beta-lactamase 0.0108 0.0713 0.0811
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.009 0.014
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0267 0.0447
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0713 0.1091
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0072 0.0415 0.0602
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1516 0.1727
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0213 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Echinococcus multilocularis dna polymerase kappa 0.0128 0.0883 0.135
Entamoeba histolytica acyl-coA synthetase, putative 0.0043 0.0176 0.0275
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.009 0.014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0692 0.1159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0461 0.1584
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0667 0.2664
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0325 0.0544
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0713 0.1197
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0461 0.4136
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0461 0.0406
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0137 0.0753
Toxoplasma gondii hypothetical protein 0.0049 0.0226 0.1598
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0116 0.0153
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.6537 1
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0713 0.1197
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0116 0.0194
Leishmania major DNA polymerase kappa, putative 0.0033 0.009 0.014
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0232 0.0295
Loa Loa (eye worm) hypothetical protein 0.0053 0.0258 0.0292
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.082 0.0933
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0474 0.3951
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0267 0.0409
Brugia malayi beta-lactamase family protein 0.0108 0.0713 0.0811
Brugia malayi CXXC zinc finger family protein 0.0052 0.0252 0.0285
Schistosoma mansoni survival motor neuron protein 0.0146 0.1028 0.1638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0461 0.0737
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Plasmodium vivax SET domain protein, putative 0.0156 0.111 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.009 0.1299
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Giardia lamblia PHD finger protein 15 0.0059 0.0304 0.3607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.17 0.26
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.009 0.0304
Echinococcus multilocularis dual specificity 0.0078 0.0462 0.0707
Mycobacterium ulcerans DNA polymerase IV 0.0128 0.0883 0.2158
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0251 0.0847
Brugia malayi ImpB/MucB/SamB family protein 0.0152 0.1076 0.1225
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0883 0.3608
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0356 0.0595
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1014 0.4182
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2343 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0213 0.0261
Brugia malayi jmjC domain containing protein 0.0192 0.1407 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0168 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0686 0.5967
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.1028 0.1171
Mycobacterium ulcerans DNA polymerase IV 0.0128 0.0883 0.2158
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0168 0.011
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0461 0.0524
Onchocerca volvulus 0.0054 0.0266 0.0209
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1501 0.2509
Echinococcus granulosus peregrin 0.0059 0.0304 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0174 0.0507
Plasmodium vivax acyl-CoA synthetase, putative 0.0032 0.0086 0.0742
Mycobacterium ulcerans hypothetical protein 0.009 0.0563 0.1323
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0232 0.1658
Echinococcus granulosus lamin dm0 0.0054 0.0266 0.0444
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0713 0.0811
Trichomonas vaginalis DNA polymerase eta, putative 0.0128 0.0883 0.0829
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0713 0.2866
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Echinococcus granulosus GPCR family 2 0.0065 0.0356 0.0595
Schistosoma mansoni terminal deoxycytidyl transferase 0.0105 0.0692 0.107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0713 0.1106
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0692 0.0787
Brugia malayi jmjC domain containing protein 0.0074 0.043 0.0489
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0101 0.0653 0.2603
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0667 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0156 0.111 0.1776
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0267 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Brugia malayi MAP kinase sur-1 0.005 0.0232 0.0263
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0461 0.1056
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0101 0.0653 0.2603
Trypanosoma brucei protein kinase, putative 0.005 0.0232 0.0764
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.043 0.0629
Loa Loa (eye worm) hypothetical protein 0.0072 0.0415 0.0471
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.009 0.0563 0.4804
Mycobacterium ulcerans hypothetical protein 0.0108 0.0713 0.1714
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0111 0.0739 0.2981
Leishmania major DNA polymerase eta, putative 0.0079 0.0474 0.1819
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0199 0.0333
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0325 0.1169
Loa Loa (eye worm) hypothetical protein 0.0054 0.0267 0.0303
Plasmodium falciparum pyruvate kinase 0.0029 0.0058 0.0817
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0168 0.0189
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0168 0.028
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.043 0.0719
Toxoplasma gondii exonuclease III APE 0.0078 0.0461 0.3834
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0156 0.111 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Trichomonas vaginalis set domain proteins, putative 0.1229 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0713 0.2866
Schistosoma mansoni gabp alpha 0.0072 0.0418 0.0609
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0085 0.005
Schistosoma mansoni hypothetical protein 0.0046 0.0199 0.0239
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0213 0.0356
Schistosoma mansoni hypothetical protein 0.0299 0.2295 0.3776
Echinococcus multilocularis lamin dm0 0.0054 0.0266 0.0407
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.17 0.2841
Loa Loa (eye worm) hypothetical protein 0.0716 0.5748 0.6557
Brugia malayi MH2 domain containing protein 0.0033 0.0095 0.0107
Brugia malayi intermediate filament protein 0.0054 0.0266 0.0301
Echinococcus granulosus dnaJ subfamily B 0.0744 0.5982 1
Plasmodium falciparum acyl-CoA synthetase 0.0032 0.0086 0.1238
Echinococcus granulosus lamin 0.0054 0.0266 0.0444
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0667 0.5993
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0418 0.064
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0058 0.0064
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.009 0.014
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0266 0.0301
Schistosoma mansoni hypothetical protein 0.0305 0.2343 0.3858
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0266 0.0301
Loa Loa (eye worm) hypothetical protein 0.0077 0.0455 0.0517
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0199 0.0305
Echinococcus granulosus leucine aminopeptidase protein 0.0101 0.0653 0.1091
Echinococcus multilocularis survival motor neuron protein 1 0.0716 0.5748 0.8793
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0132 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0078 0.0462 0.1769
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0095 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.3878 0.4423
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0713 0.0659
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0213 0.0241
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0299 0.2295 0.3511
Schistosoma mansoni ets-related 0.022 0.1639 0.2669
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0713 0.1197
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0713 0.1197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0176 0.0216
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1407 0.2352
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Brugia malayi Pyruvate kinase, muscle isozyme 0.0029 0.0058 0.0064
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.009 0.0563 0.1323
Echinococcus multilocularis geminin 0.0707 0.5675 0.8682
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.009 0.014
Trypanosoma brucei unspecified product 0.0073 0.0421 0.1589
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0156 0.111 0.1698
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0461 0.0706
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0101 0.0653 0.2603
Echinococcus granulosus survival motor neuron protein 1 0.0716 0.5748 0.9609
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0713 0.1192
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0461 0.1765
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0461 0.1765
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0043 0.0176 0.0216
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Entamoeba histolytica hypothetical protein 0.0078 0.0462 0.1587
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2343 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.009 0.014
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0168 0.0236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0299 0.2295 0.3837
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0267 0.0353
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Trypanosoma brucei DNA polymerase eta, putative 0.0152 0.1076 0.4454
Echinococcus granulosus tumor protein p63 0.0329 0.2547 0.4258
Giardia lamblia DNA damage repair protein 0.0033 0.009 0.0469
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0116 0.0554
Loa Loa (eye worm) fli-1 protein 0.022 0.1639 0.1868
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0563 0.0924
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0232 0.0355
Brugia malayi hypothetical protein 0.0716 0.5748 0.6557
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.009 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.0835 0.3401
Mycobacterium ulcerans beta-lactamase 0.0108 0.0713 0.1714
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0101 0.0653 0.5866
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.009 0.014
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0713 0.1714
Entamoeba histolytica deoxycytidyl transferase, putative 0.0105 0.0692 0.2643
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0232 0.2561
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0168 0.0256
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0979 0.1115
Brugia malayi Ets-domain containing protein 0.0072 0.0418 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0304 0.2711
Brugia malayi mbt repeat family protein 0.0048 0.0213 0.0241
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0418 0.0475
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Leishmania major DNA polymerase kappa, putative 0.0111 0.0739 0.2981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Schistosoma mansoni smad 0.0033 0.0095 0.0063
Schistosoma mansoni hypothetical protein 0.0146 0.1028 0.1638

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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