Detailed information for compound 757890

Basic information

Technical information
  • TDR Targets ID: 757890
  • Name: N-(3-cyanophenyl)-1-(4-methoxyphenyl)-2,5-dio xo-7,8-dihydro-6H-quinoline-3-carboxamide
  • MW: 413.425 | Formula: C24H19N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c2CCCC(=O)c2cc(c1=O)C(=O)Nc1cccc(c1)C#N
  • InChi: 1S/C24H19N3O4/c1-31-18-10-8-17(9-11-18)27-21-6-3-7-22(28)19(21)13-20(24(27)30)23(29)26-16-5-2-4-15(12-16)14-25/h2,4-5,8-13H,3,6-7H2,1H3,(H,26,29)
  • InChiKey: PISWZKKGGBKFAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyanophenyl)-2,5-diketo-1-(4-methoxyphenyl)-7,8-dihydro-6H-quinoline-3-carboxamide
  • ST5027276
  • ZINC00809721
  • BAS 07464507

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0418 0.0699
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0032 0.0086 0.0073
Schistosoma mansoni hypothetical protein 0.0299 0.2295 0.3776
Echinococcus granulosus smad 0.0033 0.0095 0.0159
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0078 0.0462 0.0525
Echinococcus multilocularis lamin dm0 0.0054 0.0266 0.0407
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Loa Loa (eye worm) hypothetical protein 0.0065 0.0356 0.0404
Mycobacterium ulcerans DNA polymerase IV 0.0128 0.0883 0.2158
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.009 0.014
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0095 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0028
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0713 0.1197
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0883 0.3608
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0232 0.0355
Schistosoma mansoni ap endonuclease 0.0078 0.0461 0.0681
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Loa Loa (eye worm) hypothetical protein 0.01 0.065 0.074
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0085 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0356 0.0544
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0232 0.0764
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0072 0.0415 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0461 0.1765
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0116 0.0153
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.3878 0.4423
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0713 0.1197
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.028 0.0974
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0168 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0713 0.641
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2343 1
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0213 0.0325
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0156 0.111 1
Echinococcus granulosus peregrin 0.0059 0.0304 0.0508
Echinococcus granulosus dnaJ subfamily B 0.0744 0.5982 1
Echinococcus granulosus intermediate filament protein 0.0054 0.0266 0.0444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0356 0.0404
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1407 0.2152
Brugia malayi Protein kinase domain containing protein 0.0078 0.0462 0.0525
Toxoplasma gondii exonuclease III APE 0.0078 0.0461 0.3834
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0232 0.0764
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.009 0.1299
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0168 0.1611
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0232 0.0764
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0462 0.0682
Loa Loa (eye worm) hypothetical protein 0.0048 0.0213 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.028 0.0974
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0713 0.1197
Echinococcus granulosus survival motor neuron protein 1 0.0716 0.5748 0.9609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0176 0.0309
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0102 0.0667 0.0759
Echinococcus granulosus cpg binding protein 0.0055 0.0276 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0713 0.2866
Schistosoma mansoni terminal deoxycytidyl transferase 0.0105 0.0692 0.107
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0461 0.0706
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0461 0.0524
Echinococcus multilocularis musashi 0.0054 0.0266 0.0407
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0713 0.1714
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0232 0.2561
Brugia malayi jmjC domain containing protein 0.0192 0.1407 0.1603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Echinococcus multilocularis GPCR, family 2 0.0065 0.0356 0.0544
Schistosoma mansoni cpg binding protein 0.0055 0.0276 0.0369
Schistosoma mansoni hypothetical protein 0.0744 0.5982 1
Entamoeba histolytica protein kinase, putative 0.0078 0.0462 0.1587
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.009 0.014
Echinococcus granulosus geminin 0.0707 0.5675 0.9487
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2343 1
Loa Loa (eye worm) Smad1 0.0033 0.0095 0.0107
Brugia malayi beta-lactamase family protein 0.0108 0.0713 0.0811
Giardia lamblia DINP protein human, muc B family 0.0111 0.0739 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0043 0.0176 0.0275
Treponema pallidum licC protein (licC) 0.009 0.0563 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.043 0.0719
Trypanosoma brucei unspecified product 0.0073 0.0421 0.1589
Leishmania major DNA polymerase eta, putative 0.0079 0.0474 0.1819
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0474 0.3951
Brugia malayi beta-lactamase 0.0108 0.0713 0.0811
Schistosoma mansoni survival motor neuron protein 0.0146 0.1028 0.1638
Plasmodium vivax SET domain protein, putative 0.0156 0.111 1
Brugia malayi follicle stimulating hormone receptor 0.0233 0.175 0.1995
Schistosoma mansoni hypothetical protein 0.014 0.0979 0.1555
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1407 0.2352
Loa Loa (eye worm) hypothetical protein 0.0077 0.0455 0.0517
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0667 1
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0356 0.0595
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0267 0.0447
Schistosoma mansoni gabp alpha 0.0072 0.0418 0.0609
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0037
Mycobacterium ulcerans hypothetical protein 0.009 0.0563 0.1323
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0266 0.0301
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.043 0.0489
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0218 0.0271
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.082 0.0933
Schistosoma mansoni inositol monophosphatase 0.0036 0.0116 0.0098
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0474 0.1819
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0266 0.0301
Leishmania major DNA polymerase kappa, putative 0.0033 0.009 0.014
Echinococcus granulosus tumor protein p63 0.0329 0.2547 0.4258
Leishmania major DNA polymerase kappa, putative 0.0111 0.0739 0.2981
Echinococcus multilocularis Smad4 0.0033 0.0095 0.0146
Echinococcus multilocularis microtubule associated protein 2 0.0658 0.5272 0.8064
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0713 0.1106
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.0301
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0461 0.1056
Leishmania major DNA damage repair protein, putative 0.0033 0.009 0.014
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0213 0.0261
Onchocerca volvulus 0.0108 0.0713 0.0659
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0461 0.69
Brugia malayi Pre-SET motif family protein 0.108 0.8765 1
Onchocerca volvulus 0.0054 0.0266 0.0209
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0356 0.0544
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Trichomonas vaginalis set domain proteins, putative 0.1229 1 1
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0494 0.0825
Plasmodium vivax pyruvate kinase, putative 0.0029 0.0058 0.049
Trypanosoma brucei protein kinase, putative 0.005 0.0232 0.0764
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0713 0.1192
Toxoplasma gondii hypothetical protein 0.0049 0.0226 0.1598
Mycobacterium ulcerans hypothetical protein 0.016 0.1149 0.2854
Onchocerca volvulus 0.0054 0.0266 0.0209
Onchocerca volvulus 0.0052 0.0252 0.0195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0043 0.0176 0.0275
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0028
Brugia malayi CXXC zinc finger family protein 0.0052 0.0252 0.0285
Trichomonas vaginalis DNA polymerase eta, putative 0.0128 0.0883 0.0829
Brugia malayi hypothetical protein 0.0299 0.2295 0.2617
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0461 0.0406
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0111 0.0739 0.1245
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0418 0.0475
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0168 0.011
Leishmania major DNA polymerase eta, putative 0.0152 0.1076 0.4454
Loa Loa (eye worm) hypothetical protein 0.0716 0.5748 0.6557
Mycobacterium ulcerans hypothetical protein 0.009 0.0563 0.1323
Schistosoma mansoni intermediate filament proteins 0.0054 0.0266 0.0351
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.049 0.3879 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0304 0.0415
Brugia malayi Bromodomain containing protein 0.0059 0.0304 0.0344
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0116 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0132 0.0125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0461 0.1765
Mycobacterium ulcerans lipase LipD 0.0108 0.0713 0.1714
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0713 0.1714
Brugia malayi Pyruvate kinase, M2 isozyme 0.0029 0.0058 0.0064
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0304 0.0508
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0713 0.1197
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0667 0.5993
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.043 0.0629
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0174 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0692 0.1159
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.009 0.014
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0325 0.1169
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.043 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0168 0.0189
Echinococcus multilocularis dual specificity 0.0078 0.0462 0.0707
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0232 0.0355
Toxoplasma gondii leucyl aminopeptidase LAP 0.0101 0.0653 0.5653
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Echinococcus granulosus dna polymerase kappa 0.0128 0.0883 0.1475
Schistosoma mansoni inositol monophosphatase 0.0036 0.0116 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Loa Loa (eye worm) hypothetical protein 0.0072 0.0415 0.0471
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0213 0.0356
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Echinococcus granulosus dual specificity 0.0078 0.0462 0.0772
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0043 0.0176 0.0309
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0267 0.0353
Brugia malayi Pyruvate kinase, muscle isozyme 0.0029 0.0058 0.0064
Loa Loa (eye worm) MBCTL1 0.0054 0.0267 0.0303
Echinococcus multilocularis cpg binding protein 0.0055 0.0276 0.0423
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0713 0.0811
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0299 0.2295 0.3511
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.009 0.0054
Brugia malayi MH1 domain containing protein 0.0033 0.0095 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.009 0.014
Plasmodium falciparum pyruvate kinase 0.0029 0.0058 0.0817
Loa Loa (eye worm) hypothetical protein 0.0077 0.0455 0.0517
Loa Loa (eye worm) hypothetical protein 0.0056 0.028 0.0318
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0267 0.0409
Mycobacterium ulcerans hypothetical protein 0.0108 0.0713 0.1714
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0078 0.0462 0.1769
Echinococcus granulosus microtubule associated protein 2 0.0658 0.5272 0.8813
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0035 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0304 0.2711
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0667 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0667 0.2664
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0713 0.2866
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0232 0.0388
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0979 0.1115
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0157 0.0176
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0267 0.0409
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0168 0.048
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0325 0.254
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.009 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.009 0.014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0095 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0095 0.0107
Brugia malayi MAP kinase sur-1 0.005 0.0232 0.0263
Giardia lamblia PHD finger protein 15 0.0059 0.0304 0.3607
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0213 0.0356
Brugia malayi intermediate filament protein 0.0054 0.0266 0.0301
Echinococcus granulosus GPCR family 2 0.0065 0.0356 0.0595
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0462 0.1587
Schistosoma mansoni cpg binding protein 0.0055 0.0276 0.0369
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0189
Brugia malayi MH2 domain containing protein 0.0033 0.0095 0.0107
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0095 0.0159
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0713 0.1197
Schistosoma mansoni lamin 0.0054 0.0266 0.0351
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.009 0.014
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0692 0.0787
Echinococcus granulosus Smad4 0.0033 0.0095 0.0159
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0029 0.006 0.0066
Mycobacterium ulcerans hypothetical protein 0.0033 0.009 0.0084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.17 0.1937
Onchocerca volvulus 0.0146 0.1028 0.0976
Onchocerca volvulus 0.0072 0.0415 0.0359
Brugia malayi polk-prov protein 0.0056 0.028 0.0318
Trypanosoma brucei unspecified product 0.0123 0.0835 0.3401
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0713 0.1106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0176 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.108 0.8765 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0168 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Brugia malayi mbt repeat family protein 0.0048 0.0213 0.0241
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0325 0.0488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.17 0.26
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.3878 0.4423
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1014 0.4182
Echinococcus granulosus lamin 0.0054 0.0266 0.0444
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0168 0.0185
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0667 0.2664
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Brugia malayi Ets-domain containing protein 0.0072 0.0418 0.0475
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0461 0.0771
Mycobacterium ulcerans hypothetical protein 0.0043 0.0176 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Echinococcus multilocularis survival motor neuron protein 1 0.0716 0.5748 0.8793
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Schistosoma mansoni hypothetical protein 0.0065 0.0356 0.0503
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0299 0.2295 0.3837
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.009 0.0779
Plasmodium falciparum M17 leucyl aminopeptidase 0.0101 0.0653 0.9788
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0713 0.1091
Brugia malayi jmjC domain containing protein 0.0074 0.043 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1014 0.4182
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1516 0.1727
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.17 0.2841
Echinococcus multilocularis dna polymerase eta 0.0152 0.1076 0.1646
Mycobacterium ulcerans beta-lactamase 0.0108 0.0713 0.1714
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0101 0.0653 0.5866
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0232 0.0295
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0111 0.0739 0.2981
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1501 0.2296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0689 0.5531 1
Echinococcus multilocularis smad 0.0033 0.0095 0.0146
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0078 0.0462 0.1769
Loa Loa (eye worm) hypothetical protein 0.0062 0.0331 0.0376
Plasmodium falciparum phd finger protein, putative 0.0059 0.0304 0.4524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Entamoeba histolytica hypothetical protein 0.0078 0.0462 0.1587
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0156 0.111 0.1776
Mycobacterium leprae Probable lipase LipE 0.0108 0.0713 0.1714
Schistosoma mansoni smad1 5 8 and 0.0033 0.0095 0.0063
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0168 0.011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.17 0.2772
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0032 0.0086 0.0469
Brugia malayi ImpB/MucB/SamB family protein 0.0152 0.1076 0.1225
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.009 0.0563 0.1323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.1028 0.1171
Echinococcus multilocularis geminin 0.0707 0.5675 0.8682
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1014 0.4182
Echinococcus multilocularis lamin 0.0054 0.0266 0.0407
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0563 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0168 0.048
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0168 0.0256
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0116 0.0059
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0304 0.0465
Brugia malayi Fli-1 protein 0.022 0.1639 0.1868
Schistosoma mansoni ap endonuclease 0.0078 0.0461 0.0681
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0176 0.0309
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0105 0.0692 0.1059
Schistosoma mansoni microtubule-associated protein tau 0.0658 0.5272 0.8801
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0101 0.0653 0.2603
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0325 0.0544
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0713 0.0659
Onchocerca volvulus 0.0108 0.0713 0.0659
Echinococcus granulosus pyruvate kinase 0.0029 0.0058 0.0097
Onchocerca volvulus 0.0156 0.111 0.1058
Trypanosoma cruzi DNA polymerase eta, putative 0.0152 0.1076 0.4454
Brugia malayi Ets-domain containing protein 0.0072 0.0418 0.0475
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0713 0.0659
Loa Loa (eye worm) hypothetical protein 0.014 0.0979 0.1115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0325 0.0497
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0232 0.0764
Echinococcus multilocularis pyruvate kinase 0.0029 0.0058 0.0089
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0461 0.0524
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0058 0.0064
Brugia malayi hypothetical protein 0.0716 0.5748 0.6557
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.009 0.014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1516 0.1727
Brugia malayi MH2 domain containing protein 0.049 0.3878 0.4423
Plasmodium falciparum acyl-CoA synthetase 0.0032 0.0086 0.1238
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0461 0.1765
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0461 0.1584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0085 0.0071
Onchocerca volvulus 0.0108 0.0713 0.0659
Toxoplasma gondii ABC1 family protein 0.0108 0.0713 0.6225
Loa Loa (eye worm) hypothetical protein 0.0205 0.1516 0.1727
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1149 0.1993
Loa Loa (eye worm) inositol-1 0.0036 0.0116 0.013
Giardia lamblia DNA damage repair protein 0.0033 0.009 0.0469
Loa Loa (eye worm) fli-1 protein 0.022 0.1639 0.1868
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0032 0.0086 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0356 0.0595
Entamoeba histolytica deoxycytidyl transferase, putative 0.0105 0.0692 0.2643
Brugia malayi MH2 domain containing protein 0.0033 0.0095 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0128 0.0883 0.2158
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus multilocularis leucine aminopeptidase protein 0.0101 0.0653 0.0999
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0213 0.0261
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0116 0.0178
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0713 0.1197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0266 0.0301
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.009 0.014
Loa Loa (eye worm) hypothetical protein 0.0053 0.0258 0.0292
Echinococcus granulosus histone lysine methyltransferase setb 0.0156 0.111 0.1856
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0101 0.0653 0.1557
Echinococcus multilocularis L aminoadipate semialdehyde 0.0072 0.0415 0.0634
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0101 0.0653 0.1426
Schistosoma mansoni hypothetical protein 0.0146 0.1028 0.1638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.17 0.1937
Echinococcus multilocularis pyruvate kinase 0.0029 0.0058 0.0089
Schistosoma mansoni transcription factor LCR-F1 0.0299 0.2295 0.3776
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0461 0.1765
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0105 0.0692 0.0787
Schistosoma mansoni hypothetical protein 0.0305 0.2343 0.3858
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0563 0.0924
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0251 0.0847
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0043 0.0176 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0356 0.0404
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0461 0.0406
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0156 0.111 0.1698
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0267 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0461 0.4136
Brugia malayi mbt repeat family protein 0.0048 0.0213 0.0241
Schistosoma mansoni ets-related 0.022 0.1639 0.2669
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0199
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0058 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Loa Loa (eye worm) hypothetical protein 0.0152 0.1076 0.1225
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0101 0.0653 0.2603
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0304 0.2336
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0176 0.0199
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0116 0.0194
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0667 0.5787
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Schistosoma mansoni Smad4 0.0033 0.0095 0.0063
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0168 0.028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0095 0.0159
Mycobacterium tuberculosis Conserved protein 0.0108 0.0713 0.1197
Echinococcus granulosus L aminoadipate semialdehyde 0.0072 0.0415 0.0693
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0406 0.0621
Entamoeba histolytica acyl-CoA synthetase, putative 0.0043 0.0176 0.0275
Loa Loa (eye worm) hypothetical protein 0.0108 0.0713 0.0811
Loa Loa (eye worm) beta-lactamase 0.0108 0.0713 0.0811
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0105 0.0692 0.1157
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0116 0.0554
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0213 0.0261
Trypanosoma brucei DNA polymerase eta, putative 0.0152 0.1076 0.4454
Loa Loa (eye worm) hypothetical protein 0.0156 0.111 0.1265
Trichomonas vaginalis esterase, putative 0.0108 0.0713 0.0659
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0232 0.0388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0176 0.0216
Echinococcus granulosus leucine aminopeptidase protein 0.0101 0.0653 0.1091
Echinococcus multilocularis pyruvate kinase 0.0023 0.0008 0.0012
Echinococcus granulosus dna polymerase eta 0.0152 0.1076 0.1798
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.17 0.26
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.049 0.3879 1
Schistosoma mansoni hypothetical protein 0.0046 0.0199 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0232 0.0176
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0168 0.028
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0713 0.1714
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0267 0.0303
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0213 0.0156
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0325 0.0451
Onchocerca volvulus 0.0048 0.0218 0.0161
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0252 0.0285
Leishmania major hypothetical protein, conserved 0.0108 0.0713 0.2866
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0232 0.0764
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0043 0.0176 0.0216
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0095 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Brugia malayi Pre-SET motif family protein 0.0156 0.111 0.1265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Schistosoma mansoni lamin 0.0054 0.0266 0.0351
Schistosoma mansoni hypothetical protein 0.0707 0.5675 0.9482
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Brugia malayi hypothetical protein 0.0066 0.0366 0.0416
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0095 0.0063
Leishmania major hypothetical protein, conserved 0.0102 0.0667 0.2664
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0667 0.2664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0071 0.0024
Brugia malayi MH1 domain containing protein 0.0033 0.0095 0.0107
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0713 0.0659
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.175 0.1995
Brugia malayi PHD-finger family protein 0.0059 0.0304 0.0344
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0325 0.0451
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0232 0.1658
Echinococcus multilocularis dna polymerase kappa 0.0128 0.0883 0.135
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0156 0.111 0.1698
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0176 0.0309
Onchocerca volvulus 0.0043 0.0176 0.0119
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0101 0.0653 0.2603
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0101 0.0653 0.1087
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0072 0.0415 0.0471
Brugia malayi Inositol-1 0.0036 0.0116 0.013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0325 0.0699
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0035 0.0053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0267 0.0303
Plasmodium vivax acyl-CoA synthetase, putative 0.0032 0.0086 0.0742
Schistosoma mansoni cpg binding protein 0.0052 0.0252 0.0327
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.6537 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Onchocerca volvulus 0.0048 0.0213 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0461 0.592
Schistosoma mansoni hypothetical protein 0.0059 0.0304 0.0415
Loa Loa (eye worm) hypothetical protein 0.0032 0.0086 0.0096
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0232 0.0764
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.111 0.1776
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.2343 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0043 0.0176 0.0517
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0149 0.1054 0.1761
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0168 0.028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0199 0.0305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1516 0.1727
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0356 0.0404
Brugia malayi hypothetical protein 0.0102 0.0667 0.0759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.17 0.2841
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0128 0.0883 0.0829
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0494 0.0755
Schistosoma mansoni smad 0.0033 0.0095 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0232 0.0263
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.009 0.0304
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0461 0.0737
Echinococcus granulosus lamin dm0 0.0054 0.0266 0.0444
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0232 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0713 0.2866
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.0739 0.2981
Chlamydia trachomatis cytosol aminopeptidase 0.0101 0.0653 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0213 0.0325
Echinococcus multilocularis tumor protein p63 0.0329 0.2547 0.3896
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0116 0.0784 0.1225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0116 0.0255
Mycobacterium ulcerans leucyl aminopeptidase 0.0101 0.0653 0.1557
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0468 0.1796
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0199 0.0333
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0213 0.0241
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.2343 1
Schistosoma mansoni DNA polymerase eta 0.0152 0.1076 0.1718
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0461 0.0917
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0168 0.0256
Loa Loa (eye worm) hypothetical protein 0.0059 0.0304 0.0344
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0116 0.0059
Trypanosoma brucei unspecified product 0.0073 0.0421 0.1589
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus granulosus pyruvate kinase 0.0029 0.0058 0.0097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0713 0.1197
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0174 0.0507
Brugia malayi beta-lactamase family protein 0.0108 0.0713 0.0811
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0686 0.5967
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0137 0.0753
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1501 0.2509
Echinococcus multilocularis peregrin 0.0059 0.0304 0.0465
Brugia malayi Smad1 0.0033 0.0095 0.0107
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0304 0.0344
Schistosoma mansoni jumonji domain containing protein 0.0152 0.108 0.1726
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0058 0.0064
Echinococcus multilocularis dnaJ subfamily B 0.0744 0.5982 0.9151
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0304 0.2336
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0176 0.0309
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0713 0.0811
Entamoeba histolytica protein kinase, putative 0.0078 0.0462 0.1587
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0168 0.0236
Onchocerca volvulus Alhambra homolog 0.0059 0.0304 0.0247
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.049 0.3879 0.6982
Trypanosoma cruzi DNA polymerase kappa, putative 0.0128 0.0883 0.3608
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0105 0.0692 0.107
Entamoeba histolytica hypothetical protein 0.0299 0.2295 1
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0418 0.064
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.009 0.0563 0.4804
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.0835 0.3401
Schistosoma mansoni hypothetical protein 0.0707 0.5675 0.9482
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0101 0.0653 0.2603
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0168 0.011
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.049 0.3879 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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