TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 490.698 | Formula: C27H42N2O4S
H donors: 2 H acceptors: 3 LogP: 6.74 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CSCCC(C(=O)NC(C(=O)OC)C(C)C)NC(=O)c1ccc(cc1)C1CCC(CC1)CCC
InChi: 1S/C27H42N2O4S/c1-6-7-19-8-10-20(11-9-19)21-12-14-22(15-13-21)25(30)28-23(16-17-34-5)26(31)29-24(18(2)3)27(32)33-4/h12-15,18-20,23-24H,6-11,16-17H2,1-5H3,(H,28,30)(H,29,31)
InChiKey: MGVLMDONNTXTJH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0034	0.0032	0.006
Echinococcus multilocularis	liprin alpha 2	0.0051	0.0128	0.0211
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.0656	0.371	0.6171
Echinococcus multilocularis	histone acetyltransferase myst4	0.0034	0.0032	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Brugia malayi	cask-interacting protein 2	0.0051	0.0128	0.0242
Entamoeba histolytica	hypothetical protein	0.0038	0.0052	0.5
Schistosoma mansoni	sex comb on midleg homolog	0.0533	0.298	0.298
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0034	0.0032	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0917	0.525	1
Schistosoma mansoni	cpg binding protein	0.0091	0.0368	0.0368
Echinococcus granulosus	TAF3 RNA polymerase II TATA box binding protein	0.0034	0.0032	0.0053
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0772	0.4393	0.4392
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.1046	0.6011	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0031
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0006	0.0045
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0035	0.0376
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0242	0.1257	0.2091
Brugia malayi	PHD-finger family protein	0.0044	0.0089	0.0168
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.1077	0.2051
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0002	0.0002
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0917	0.525	1
Brugia malayi	hypothetical protein	0.0239	0.1239	0.2359
Echinococcus granulosus	chromobox protein 2	0.0395	0.2166	0.3603
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0051	0.0128	0.0211
Brugia malayi	mbt repeat family protein	0.0917	0.525	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0192	0.0965	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1239	0.2359
Brugia malayi	Hypothetical C28H8.9 in chromosome III	0.0034	0.0032	0.006
Echinococcus granulosus	snurportin 1	0.0311	0.1665	0.277
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Brugia malayi	Pre-SET motif family protein	0.0031	0.0014	0.0026
Brugia malayi	hypothetical protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0037	0.0046	0.0082
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0116	0.0116
Schistosoma mansoni	DNAj-like protein	0.0051	0.0128	0.0127
Schistosoma mansoni	cpg binding protein	0.0057	0.0165	0.0164
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0031
Schistosoma mansoni	myst histone acetyltransferase	0.0034	0.0032	0.0031
Echinococcus granulosus	remodeling and spacing factor 1	0.0034	0.0032	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0032	0.006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0014	0.0013
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0032	0.1364
Trypanosoma brucei	Ring finger domain/PHD-finger, putative	0.0034	0.0032	0.2459
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Echinococcus granulosus	Sterile alpha motif type	0.0051	0.0128	0.0212
Echinococcus multilocularis	liprin alpha 2	0.0051	0.0128	0.0211
Brugia malayi	Bromodomain containing protein	0.0029	0.0002	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0035	0.5
Brugia malayi	beta-lactamase	0.0035	0.0035	0.0066
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0034	0.0032	0.0053
Echinococcus multilocularis	uro adherence factor A	0.0034	0.0032	0.0052
Brugia malayi	Bromodomain associated family protein	0.0034	0.0032	0.006
Echinococcus granulosus	liprin alpha 2	0.0051	0.0128	0.0212
Schistosoma mansoni	jumonji domain containing protein	0.0128	0.0582	0.0582
Schistosoma mansoni	cpg binding protein	0.0091	0.0368	0.0368
Toxoplasma gondii	PLU-1 family protein	0.0088	0.035	0.7399
Brugia malayi	Bromodomain containing protein	0.0034	0.0032	0.006
Echinococcus granulosus	SAM and MBT domain containing protein	0.0772	0.4393	0.7308
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0002	0.0083
Schistosoma mansoni	zinc finger protein	0.0034	0.0032	0.0031
Brugia malayi	bicaudal-C	0.0051	0.0128	0.0242
Echinococcus multilocularis	phd finger protein 12	0.0034	0.0032	0.0052
Schistosoma mansoni	zinc finger protein	0.0034	0.0032	0.0031
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.0548	0.0548
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.0282
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.115	1
Schistosoma mansoni	hypothetical protein	0.0397	0.2178	0.2178
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0051	0.0128	0.0127
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0225	0.1162	0.1161
Schistosoma mansoni	zinc finger protein	0.0034	0.0032	0.0031
Schistosoma mansoni	phd finger protein	0.0085	0.0331	0.033
Echinococcus multilocularis	histone acetyltransferase myst3	0.0085	0.0331	0.055
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0031
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0192	0.0965	0.0965
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Echinococcus multilocularis	dnaJ subfamily B	0.0397	0.2178	0.3624
Schistosoma mansoni	spingomyelin synthetase-related	0.0051	0.0128	0.0127
Plasmodium falciparum	EELM2 domain-containing protein, putative	0.0034	0.0032	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0002	0.0004
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0035	0.0066
Onchocerca volvulus		0.0051	0.0128	0.0238
Toxoplasma gondii	AP2 domain transcription factor AP2VIIa-7	0.0034	0.0032	0.0662
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0014	0.0013
Schistosoma mansoni	hypothetical protein	0.0311	0.1665	0.1664
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Echinococcus granulosus	phd finger protein 10	0.0034	0.0032	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Schistosoma mansoni	requim req/dpf2	0.0034	0.0032	0.0031
Onchocerca volvulus		0.024	0.1249	0.2375
Plasmodium falciparum	SNF2 helicase, putative	0.0034	0.0032	0.1364
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0034	0.0032	0.0052
Echinococcus granulosus	polycomb protein SCMH1	0.0533	0.298	0.4958
Trypanosoma cruzi	Kinesin-13 5, putative	0.0051	0.0128	1
Echinococcus granulosus	zinc finger protein	0.0034	0.0032	0.0053
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0035	0.5
Trypanosoma cruzi	hypothetical protein	0.0051	0.0128	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0006	0.0045
Schistosoma mansoni	polyhomeotic	0.0051	0.0128	0.0127
Plasmodium vivax	JmjC domain containing protein	0.0068	0.0229	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0035	0.0066
Schistosoma mansoni	hypothetical protein	0.0051	0.0128	0.0127
Schistosoma mansoni	phd finger protein	0.0034	0.0032	0.0031
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0051	0.0128	0.0212
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.1239	0.2061
Echinococcus granulosus	importin subunit beta 1	0.0029	0	0.0001
Onchocerca volvulus		0.0051	0.0128	0.0238
Brugia malayi	hypothetical protein	0.0051	0.0128	0.0242
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0165	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus granulosus	lysine specific demethylase 5A	0.0225	0.1162	0.1933
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Schistosoma mansoni	dpf3	0.0034	0.0032	0.0031
Plasmodium vivax	protein kinase, putative	0.0051	0.0128	0.5548
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus multilocularis	Zinc finger, DBF type	0.0034	0.0032	0.0052
Trichomonas vaginalis	set domain proteins, putative	0.024	0.1249	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0014	0.0026
Echinococcus multilocularis	phd finger protein 10	0.0034	0.0032	0.0052
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0068	0.0229	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0147	0.07	0.1164
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0035	0.0282
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0772	0.4393	0.7308
Schistosoma mansoni	sex comb on midleg homolog	0.0533	0.298	0.298
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0035	0.2743
Echinococcus granulosus	histone acetyltransferase MYST2	0.0192	0.0965	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Plasmodium falciparum	histone-lysine N-methyltransferase, H3 lysine-4 specific	0.0034	0.0032	0.1364
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0032	0.0662
Brugia malayi	PHD-finger family protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0051	0.0128	0.0238
Onchocerca volvulus		0.0054	0.015	0.0282
Brugia malayi	Shank2E	0.0051	0.0128	0.0242
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0051	0.0128	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0311	0.1665	0.317
Onchocerca volvulus		0.0057	0.0165	0.0309
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.0282
Echinococcus multilocularis	lysine specific demethylase 5A	0.0191	0.0958	0.1594
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0054	0.015	0.015
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0035	0.0066
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0051	0.0128	0.0211
Trichomonas vaginalis	inhibitor of growth, putative	0.0034	0.0032	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0032	0.0662
Brugia malayi	F/Y-rich N-terminus family protein	0.0059	0.0179	0.0339
Toxoplasma gondii	hypothetical protein	0.0051	0.0132	0.2785
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0035	0.0376
Schistosoma mansoni	hypothetical protein	0.0051	0.0128	0.0127
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0014	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Echinococcus multilocularis	TAF3 RNA polymerase II, TATA box binding protein	0.0034	0.0032	0.0052
Trichomonas vaginalis	esterase, putative	0.0035	0.0035	0.0282
Echinococcus multilocularis	PHD and RING finger domain containing protein 1	0.0034	0.0032	0.0052
Onchocerca volvulus	Tankyrase homolog	0.0051	0.0128	0.0238
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0051	0.0128	0.0212
Plasmodium vivax	SNF2 family N-terminal domain containing protein	0.0034	0.0032	0.1364
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0057	0.0168	0.0279
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0002	0.0004
Onchocerca volvulus		0.0035	0.0035	0.0063
Giardia lamblia	Kinesin-13	0.0051	0.0128	1
Echinococcus multilocularis	Sterile alpha motif SAM	0.0051	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0034	0.0032	0.0056
Echinococcus granulosus	PHD and RING finger domain containing protein 1	0.0034	0.0032	0.0053
Echinococcus granulosus	lysine specific demethylase 5B	0.0034	0.0032	0.0053
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0032	0.0662
Schistosoma mansoni	SET domain protein	0.0037	0.0046	0.0045
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0035	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Echinococcus granulosus	pdz domain containing protein	0.0051	0.0128	0.0212
Trypanosoma cruzi	Kinesin-13 5, putative	0.0051	0.0128	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0052	0.0136	0.2874
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.0472	1
Echinococcus granulosus	PHD finger protein 14	0.0034	0.0032	0.0053
Echinococcus multilocularis	polyhomeotic protein 2	0.0051	0.0128	0.0211
Echinococcus multilocularis	pdz domain containing protein	0.0051	0.0128	0.0211
Echinococcus granulosus	cpg binding protein	0.0091	0.0368	0.0612
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0035	0.0066
Echinococcus multilocularis	remodeling and spacing factor 1	0.0034	0.0032	0.0052
Schistosoma mansoni	hypothetical protein	0.0656	0.371	0.3709
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0051	0.0128	0.0127
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0035	0.0035
Echinococcus multilocularis	polycomb protein SCMH1	0.0533	0.298	0.4957
Schistosoma mansoni	hypothetical protein	0.0029	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0031
Echinococcus granulosus	dnaJ subfamily B	0.0397	0.2178	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0965	0.1837
Brugia malayi	AIDA-1b	0.0051	0.0128	0.0242
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0014	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Brugia malayi	beta-lactamase family protein	0.0035	0.0035	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0002	0.0004
Loa Loa (eye worm)	jmjC domain-containing protein	0.0314	0.1683	0.3204
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0032	0.0662
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0192	0.0965	0.1837
Schistosoma mansoni	myst-related protein	0.0038	0.0052	0.0052
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0071	0.0117
Schistosoma mansoni	PHD zinc finger protein XAP135-related	0.0034	0.0032	0.0031
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0051	0.0128	0.0212
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0014	0.0013
Echinococcus granulosus	histone acetyltransferase myst3	0.0085	0.0331	0.055
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0035	0.0059
Brugia malayi	Sphingomyelin synthase-related 1	0.0051	0.0128	0.0242
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.0051	0.0128	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0035	0.0282
Echinococcus granulosus	histone acetyltransferase myst4	0.0034	0.0032	0.0053
Schistosoma mansoni	bromodomain containing protein	0.0034	0.0032	0.0031
Onchocerca volvulus		0.0049	0.0116	0.0217
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0116	0.022
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.1046	0.6011	1
Schistosoma mansoni	fyve-containing	0.0034	0.0032	0.0031
Echinococcus multilocularis	chromobox protein 2	0.0395	0.2166	0.3603
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0014	0.0023
Onchocerca volvulus		0.0034	0.0032	0.0056
Echinococcus granulosus	uro adherence factor A	0.0034	0.0032	0.0053
Echinococcus granulosus	Zinc finger DBF type	0.0034	0.0032	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Brugia malayi	RNA, U transporter 1	0.0083	0.0318	0.0604
Schistosoma mansoni	chromobox protein	0.0395	0.2166	0.2165
Loa Loa (eye worm)	MBCTL1	0.0192	0.0965	0.1837
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Brugia malayi	Pre-SET motif family protein	0.0211	0.1077	0.2051
Plasmodium vivax	SET domain protein, putative	0.0031	0.0014	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0057	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Echinococcus multilocularis	zinc finger protein	0.0034	0.0032	0.0052
Trichomonas vaginalis	cgi-62, putative	0.0051	0.0128	0.102
Brugia malayi	CHD4 protein	0.0057	0.0168	0.0319
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0051	0.0128	0.102
Echinococcus granulosus	liprin alpha 2	0.0051	0.0128	0.0212
Echinococcus granulosus	fetal alzheimer antigen falz	0.0034	0.0032	0.0053
Echinococcus granulosus	Sterile alpha motif SAM	0.0051	0.0128	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0089	0.0168
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0165	0.0313
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0034	0.0032	0.0052
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0074	0.0268	0.568
Brugia malayi	PHD-finger family protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0034	0.0032	0.0056
Onchocerca volvulus		0.0035	0.0035	0.0063
Brugia malayi	Liprin-alpha 2	0.0051	0.0128	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0192	0.0965	0.1605
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Echinococcus multilocularis	snurportin 1	0.0311	0.1665	0.2769
Loa Loa (eye worm)	F/Y-rich family protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0035	0.0035	0.0063
Echinococcus multilocularis	Sterile alpha motif type	0.0051	0.0128	0.0211
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0147	0.07	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0207	0.0393
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0002	0.0003
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0041	0.0327
Schistosoma mansoni	hepatitis B virus X associated protein hbxa	0.0034	0.0032	0.0031
Brugia malayi	hypothetical protein	0.0051	0.0128	0.0242
Schistosoma mansoni	bromodomain containing protein	0.0034	0.0032	0.0031
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0057	0.0168	0.028
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus multilocularis	lysine specific demethylase 5B	0.0034	0.0032	0.0052
Brugia malayi	PHD-finger family protein	0.0029	0.0002	0.0004
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0071	0.0116
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0002	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0041	0.0327
Schistosoma mansoni	myst-related protein	0.0038	0.0052	0.0052
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0188	0.0356
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0035	0.5
Brugia malayi	coiled-coil like protein 1	0.0051	0.0128	0.0242
Schistosoma mansoni	Protein aveugle	0.0051	0.0128	0.0127
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0034	0.0032	0.0052
Onchocerca volvulus		0.0034	0.0032	0.0056
Loa Loa (eye worm)	CHromoDomain protein family member	0.0057	0.0168	0.0319
Leishmania major	hypothetical protein, conserved	0.0035	0.0035	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0035	0.1522
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0192	0.0965	0.1605
Onchocerca volvulus		0.0051	0.0128	0.0238
Echinococcus granulosus	phd finger protein 12	0.0034	0.0032	0.0053
Brugia malayi	PHD-finger family protein	0.0034	0.0032	0.006
Onchocerca volvulus		0.0051	0.0128	0.0238
Echinococcus granulosus	peregrin	0.0029	0.0002	0.0004
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0051	0.0128	0.0242
Brugia malayi	mbt repeat family protein	0.0555	0.3108	0.5919
Loa Loa (eye worm)	tnks protein	0.0051	0.0128	0.0242
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0035	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Toxoplasma gondii	ABC1 family protein	0.0035	0.0035	0.0739
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0225	0.1162	0.1161
Brugia malayi	SET domain containing protein	0.0037	0.0046	0.0086
Schistosoma mansoni	hypothetical protein	0.0034	0.0032	0.0031
Echinococcus multilocularis	peregrin	0.0029	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0051	0.0128	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0128	0.0242
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.1239	0.2061
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0051	0.0128	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Plasmodium falciparum	zinc finger protein, putative	0.0038	0.0052	0.226
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0035	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0128	0.102
Echinococcus multilocularis	PHD finger protein 14	0.0034	0.0032	0.0052
Schistosoma mansoni	hypothetical protein	0.0049	0.0116	0.0116
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.0656	0.371	0.6172
Schistosoma mansoni	Protein aveugle	0.0051	0.0128	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Brugia malayi	PHD-finger family protein	0.0034	0.0032	0.006
Brugia malayi	PHD-finger family protein	0.0034	0.0032	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0032	0.0253
Brugia malayi	jmjC domain containing protein	0.0147	0.07	0.1332
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0035	0.0035
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0035	0.5
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0035	0.5
Mycobacterium ulcerans	lipase LipD	0.0035	0.0035	0.5
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0051	0.0128	0.0242
Toxoplasma gondii	SWI2/SNF2-containing PHD finger protein	0.0034	0.0032	0.0662
Onchocerca volvulus		0.0605	0.3407	0.6488
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0041	0.0327
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0035	0.5
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0002	0.0083
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0002	0.004
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0034	0.0032	0.0031
Echinococcus multilocularis	cpg binding protein	0.0091	0.0368	0.0612
Loa Loa (eye worm)	AIDA-1b	0.0051	0.0128	0.0242
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0242	0.1257	0.2091
Onchocerca volvulus		0.0051	0.0128	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0032	0.006
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0032	0.006
Echinococcus granulosus	polyhomeotic protein 2	0.0051	0.0128	0.0212
Loa Loa (eye worm)	mbt repeat family protein	0.0555	0.3108	0.5919
Brugia malayi	jmjC domain containing protein	0.0314	0.1683	0.3204

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 780019