Detailed information for compound 78668

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 602.572 | Formula: C30H33Cl2N3O4S
  • H donors: 1 H acceptors: 3 LogP: 4.62 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C)[C@H](NCc1ccc(c(c1)Cl)Cl)COCc1ccccc1
  • InChi: 1S/C30H33Cl2N3O4S/c1-40(37,38)35-21-30(24-9-5-6-10-28(24)35)13-15-34(16-14-30)29(36)27(20-39-19-22-7-3-2-4-8-22)33-18-23-11-12-25(31)26(32)17-23/h2-12,17,27,33H,13-16,18-21H2,1H3/t27-/m1/s1
  • InChiKey: PEIMIJSROKINQZ-HHHXNRCGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0246 0.0409
Loa Loa (eye worm) helicase 0.0013 0.0017 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1288 0.2583
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.1288 0.194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0038 0.0072
Echinococcus multilocularis expressed protein 0.0401 0.4528 0.4528
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0313
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0286 0.043
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0051 0.0593
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1288 0.2583
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0027 0.0112
Schistosoma mansoni cell polarity protein 0.0024 0.0141 0.0276
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0246 0.0657
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Onchocerca volvulus 0.008 0.079 0.1325
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0286 0.0567
Echinococcus granulosus synaptojanin 1 0.0016 0.0051 0.0077
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.053 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0117 0.1225 0.2354
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0614 0.1174
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0128
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.2549 0.512
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.1288 0.6248
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Onchocerca volvulus 0.0051 0.0457 0.0764
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.008 0.079 0.1582
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0286 0.0543
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0286 0.0543
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0269 0.2063
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0512 0.0978
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0051 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0512 0.0984
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.053 0.4097
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.1288 0.2033
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0803 0.1346
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0073 0.014
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0073 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0634 0.0634
Schistosoma mansoni nocturnin 0.0016 0.0051 0.0095
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0051 0.0077
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0246 0.5
Onchocerca volvulus 0.0017 0.0061 0.0097
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Schistosoma mansoni ap endonuclease 0.0081 0.0803 0.1608
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0246 0.1181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0286 0.0475
Onchocerca volvulus 0.0014 0.0027 0.0039
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.1288 0.616
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0151
Onchocerca volvulus 0.0522 0.594 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0061 0.0097
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0195
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0087 0.0131
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Loa Loa (eye worm) RGS-3 protein 0.0021 0.01 0.0193
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0051 0.0128
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0286 0.0567
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0225
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi nuclear receptor RXR 0.0019 0.0085 0.0157
Echinococcus granulosus geminin 0.0382 0.4305 0.6486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0023
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0067 0.01
Plasmodium vivax SET domain protein, putative 0.0066 0.0634 0.7885
Onchocerca volvulus 0.0014 0.0027 0.0039
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0051 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0061 0.0118
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0017 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Loa Loa (eye worm) phosphofructokinase 0.0123 0.1288 0.2475
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1735 0.8388
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0614 0.1228
Onchocerca volvulus 0.0014 0.0027 0.0039
Onchocerca volvulus 0.0013 0.0017 0.0023
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0073 0.0073
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0106 0.0198
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.053 0.256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0107 0.0107
Schistosoma mansoni nuclear receptor 0.0017 0.0061 0.0116
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0141 0.027
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0085 0.0164
Onchocerca volvulus 0.0021 0.0107 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0017 0.0026
Onchocerca volvulus 0.0018 0.0073 0.0117
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0085 0.0085
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.3037
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Toxoplasma gondii hypothetical protein 0.0014 0.0027 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0286 0.0543
Trichomonas vaginalis set domain proteins, putative 0.0522 0.594 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0067 0.0789
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.5203 1
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0051 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0061 0.0111
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0067 0.0127
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0109 0.0177
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0073 0.0073
Onchocerca volvulus 0.0031 0.022 0.0364
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0803 0.3889
Brugia malayi laminin alpha chain 0.0024 0.0141 0.0264
Schistosoma mansoni serine-rich repeat protein 0.0137 0.1453 0.2914
Brugia malayi nuclear hormone receptor 0.0017 0.0061 0.0111
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0107 0.0107
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0027 0.0112
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Echinococcus multilocularis synaptojanin 1 0.0016 0.0051 0.0051
Schistosoma mansoni DNA helicase recq5 0.0021 0.0109 0.0211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0061 0.0092
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0107 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0302 0.3378 0.3378
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.053 0.256
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0286 0.0549
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0803 0.6223
Schistosoma mansoni loxhd1 0.0021 0.0107 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0803 0.1346
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0269 0.1289
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0141 0.0264
Schistosoma mansoni hypothetical protein 0.0137 0.1453 0.2914
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0117 0.0884
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Echinococcus granulosus Chromo domain 0.0013 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0073 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.024 0.0399
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0073 0.014
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0109 0.0177
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0165 0.1254
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0017 0.0026
Onchocerca volvulus 0.0017 0.0061 0.0097
Schistosoma mansoni hypothetical protein 0.0382 0.4305 0.8652
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0073 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0087 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0295 0.0444
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0051 0.0095
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Schistosoma mansoni nuclear receptor 0.0017 0.0061 0.0116
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0109 0.0209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0099 0.016
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0067 0.01
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0598 0.0901
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Onchocerca volvulus Putative nachr subunit 0.0018 0.0073 0.0117
Onchocerca volvulus 0.0014 0.0027 0.0039
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0278 0.0535
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0067 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0286 0.0543
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3698 1
Brugia malayi Protein cec-1. 0.0013 0.0017 0.0026
Brugia malayi 6-phosphofructokinase 0.0123 0.1288 0.247
Onchocerca volvulus 0.0014 0.0027 0.0039
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0061 0.0118
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0073 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Plasmodium vivax JmjC domain containing protein 0.0018 0.0067 0.0789
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0117 0.0117
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.2059 0.4134
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0051 0.0593
Echinococcus multilocularis Chromo domain 0.0013 0.0017 0.0017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Brugia malayi Protein kinase domain containing protein 0.0022 0.0117 0.0218
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.053 0.4097
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0817 0.137
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0614 0.0614
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0437 0.0731
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0107 0.0162
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.021 0.0403
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0109 0.0202
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0107 0.0107
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0073 0.0139
Brugia malayi phosphofructokinase 0.0123 0.1288 0.247
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0582 0.6637 0.6637
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0073 0.011
Brugia malayi Cytochrome P450 family protein 0.0023 0.0124 0.0232
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0286 0.043
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0269 0.2063
Onchocerca volvulus 0.0018 0.0073 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0061 0.0116
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.01
Echinococcus multilocularis geminin 0.0382 0.4305 0.4305
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0286 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0278 0.0463
Echinococcus granulosus lamin 0.0056 0.0512 0.0771
Echinococcus multilocularis slit 2 protein 0.0024 0.0141 0.0141
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Schistosoma mansoni cript-related 0.0016 0.0051 0.0095
Brugia malayi hypothetical protein 0.0017 0.0061 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0061 0.0061
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0109 0.0158
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Schistosoma mansoni hypothetical protein 0.0382 0.4305 0.8652
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0186
Brugia malayi hypothetical protein 0.0019 0.0085 0.0157
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0593
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.2059 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0286 0.0549
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0803 0.6223
Echinococcus granulosus tumor protein p63 0.035 0.3935 0.5929
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0051 0.0051
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0286 0.0543
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0051 0.0051
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.3037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0286 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0124 0.0238
Brugia malayi hypothetical protein 0.0026 0.0165 0.031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0017 0.0171
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0653 0.0984
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0803 0.121
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0397 0.0662
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Toxoplasma gondii microneme protein, putative 0.0014 0.0027 0.0112
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0286 0.0475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0286 0.0286
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.0073
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus multilocularis nAChR subunit 0.0018 0.0073 0.0073
Schistosoma mansoni chromobox protein 0.0013 0.0017 0.0028
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0061 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0165 0.0316
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0051 0.0051
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0141 0.0276
Brugia malayi SET domain containing protein 0.0017 0.0053 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0286 0.0549
Schistosoma mansoni coup transcription factor 0.0036 0.0286 0.0567
Schistosoma mansoni hypothetical protein 0.0022 0.0117 0.0228
Onchocerca volvulus 0.0013 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0051 0.0369
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0017 0.0067
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0073 0.0073
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0151
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0286 0.0567
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0151
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.022 0.0423
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.2549 0.4899
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0073 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3378 0.6787
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0803 0.5
Echinococcus granulosus chromobox protein 1 0.0082 0.0817 0.1231
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0051 0.0593
Schistosoma mansoni chromobox protein 0.0082 0.0817 0.1636
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0653 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0017 0.0171
Brugia malayi hypothetical protein 0.0019 0.0085 0.0157
Brugia malayi hypothetical protein 0.0013 0.0017 0.0026
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0051 0.023
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0107 0.0206
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1288 0.2475
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0017 0.0171
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0067 0.0127
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Brugia malayi nuclear receptor NHR-88 0.0017 0.0061 0.0111
Brugia malayi Kringle domain containing protein 0.0022 0.0117 0.0218
Echinococcus granulosus phd:f box containing protein 0.0018 0.0067 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0141 0.0264
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.2059 0.4134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Echinococcus multilocularis lamin dm0 0.0056 0.0512 0.0512
Brugia malayi nuclear receptor RXR 0.0017 0.0061 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0209
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0067 0.0067
Echinococcus granulosus voltage dependent calcium channel subunit 0.0582 0.6637 1
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0106 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Schistosoma mansoni chromobox protein 0.0013 0.0017 0.0028
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0117 0.0176
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0286 0.0567
Onchocerca volvulus 0.0022 0.0117 0.0191
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2969
Echinococcus granulosus RUN 0.0021 0.0107 0.0162
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0017 0.0171
Schistosoma mansoni ap endonuclease 0.0081 0.0803 0.1608
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0286 0.043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0286 0.0543
Loa Loa (eye worm) hypothetical protein 0.0055 0.05 0.0961
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0109 0.1314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0286 0.0567
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0067 0.0067
Brugia malayi ecdysteroid receptor 0.0036 0.0286 0.0543
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0061 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.01 0.0186
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0027 0.0112
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0051 0.0095
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0085 0.0164
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0051 0.0369
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0073 0.011
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0067 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0051 0.0128
Onchocerca volvulus 0.0018 0.0073 0.0117
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0051 0.0369
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0593
Schistosoma mansoni hypothetical protein 0.0439 0.4975 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0512 0.1022
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0073 0.014
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0017 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0803 0.2163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0511
Echinococcus granulosus chromobox protein 2 0.0013 0.0017 0.0026
Brugia malayi EGF-like domain containing protein 0.0024 0.0141 0.0264
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0286 0.0567
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.053 0.053
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0051 0.0593
Brugia malayi nuclear hormone receptor 0.0036 0.0286 0.0543
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Brugia malayi ecdysone receptor 0.0017 0.0061 0.0111
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.1288 0.1288
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0563 0.1082
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.1288 0.6248
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0051 0.0369
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.2549 0.3841
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Echinococcus multilocularis tumor protein p63 0.035 0.3935 0.3935
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0027 0.0112
Echinococcus granulosus dnaJ subfamily B 0.0439 0.4975 0.7496
Brugia malayi Cache domain containing protein 0.0117 0.1225 0.2349
Echinococcus multilocularis chromobox protein 1 0.0082 0.0817 0.0817
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.011
Toxoplasma gondii microneme protein MIC4 0.0014 0.0027 0.0112
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0511
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0175 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Toxoplasma gondii exonuclease III APE 0.0081 0.0803 0.3889
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.2953 0.2953
Brugia malayi Doublecortin family protein 0.0021 0.0107 0.0199
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0286 0.0549
Schistosoma mansoni lamin 0.0056 0.0512 0.1022
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Trichomonas vaginalis rotamase, putative 0.0035 0.0269 0.0446
Echinococcus granulosus expressed protein 0.0036 0.0278 0.0419
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0254 0.2817 0.5659
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0295 0.0585
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Brugia malayi hypothetical protein 0.0017 0.0057 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0653 0.1307
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0803 1
Schistosoma mansoni hypothetical protein 0.0265 0.2953 0.5932
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0803 0.2062
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0051 0.0369
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0633 0.0954
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.2059 0.3102
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0265 0.2943 0.2943
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.01 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0651 0.1301
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0051 0.0369
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0073 0.011
Brugia malayi hypothetical protein 0.0021 0.0107 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0286 0.0549
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0061 0.0111
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.2059 0.2059
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0107 0.1298
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0067 0.0067
Onchocerca volvulus 0.0014 0.0027 0.0039
Brugia malayi nuclear receptor NHR-88 0.0036 0.0286 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0286 0.0549
Echinococcus multilocularis expressed protein 0.0036 0.0278 0.0278
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0269 0.1289
Brugia malayi CHD4 protein 0.0015 0.0038 0.0066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.3037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0202
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1288 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0151
Echinococcus granulosus bloom syndrome protein 0.0021 0.0109 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0061 0.0061
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0269 0.2063
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0061 0.0097
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0022 0.0117 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0038 0.0038
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0157
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.01 0.0193
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0186
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Schistosoma mansoni polycystin 1-related 0.0021 0.0107 0.0209
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0278 0.0529
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.01 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0017 0.0028
Onchocerca volvulus 0.0056 0.0512 0.0856
Brugia malayi hypothetical protein 0.0021 0.01 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Schistosoma mansoni cpg binding protein 0.0031 0.022 0.0435
Trichomonas vaginalis chromobox protein, putative 0.005 0.0437 0.0731
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0286 0.0567
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0004 0.0007
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0803 1
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0286 0.0543
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Schistosoma mansoni lamin 0.0056 0.0512 0.1022
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0165 0.1254
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0073 0.0073
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0056 0.0512 0.0984
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.053 0.1018
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.053 0.4097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0109 0.0109
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0067 0.0127
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0246 0.0536
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0286 0.0567
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0295 0.0295
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0017 0.0023
Brugia malayi CXXC zinc finger family protein 0.0031 0.022 0.0416
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0803 0.3744
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0017 0.0171
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0109 0.0177
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0073 0.0139
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0061 0.0092
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0061 0.0111
Echinococcus multilocularis pikachurin 0.0024 0.0141 0.0141
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0073 0.011
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0209
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0109 0.0164
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0246 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0073 0.011
Onchocerca volvulus 0.0021 0.0107 0.0175
Onchocerca volvulus 0.0016 0.0051 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.3698 0.5993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0055 0.0087
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0051 0.0369
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0551 0.0551
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0511
Onchocerca volvulus 0.0036 0.0281 0.0467
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0073 0.0073
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.053 0.4097
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0313
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0106 0.0106
Brugia malayi jmjC domain containing protein 0.0068 0.0653 0.125
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0061 0.0116
Schistosoma mansoni synaptojanin 0.0016 0.0051 0.0095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0061 0.0097
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0109 0.0284
Toxoplasma gondii hypothetical protein 0.0014 0.0027 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0457 0.0912
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0817 0.137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0109 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.054
Loa Loa (eye worm) DR-78 0.0017 0.0061 0.0118
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.3037
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0117 0.1421
Echinococcus granulosus slit 2 protein 0.0024 0.0141 0.0212
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0017 0.0026
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.4975 0.4975
Leishmania major hypothetical protein, conserved 0.0018 0.0067 0.0307
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0061 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0165 0.1254
Brugia malayi jmjC domain containing protein 0.0066 0.0633 0.121
Echinococcus granulosus pikachurin 0.0024 0.0141 0.0212
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.01
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0106 0.016
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0551 0.083
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0017 0.0028
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.01 0.0195
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Trichomonas vaginalis hypothetical protein 0.0013 0.0017 0.0023
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0073 0.0133
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0186
Brugia malayi hypothetical protein 0.0037 0.0295 0.056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0803 0.6223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0037 0.0295 0.0585
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0085 0.0128
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0341 0.3827 0.7356
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0061 0.0111
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0286 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Schistosoma mansoni cpg binding protein 0.0033 0.024 0.0476
Onchocerca volvulus 0.0018 0.0073 0.0117
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0026 0.0165 0.0784
Echinococcus granulosus voltage dependent calcium channel subunit 0.0265 0.2943 0.4434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Loa Loa (eye worm) RecQ helicase 0.0021 0.0109 0.0209
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0286 0.043
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0165 0.0784
Schistosoma mansoni lipoxygenase 0.0059 0.0551 0.1101
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0051 0.0077
Echinococcus granulosus lamin dm0 0.0056 0.0512 0.0771
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0051 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0099 0.016
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.053 0.1313
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0286 0.0567
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1288 1
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Brugia malayi nuclear receptor NHR-67 0.0017 0.0061 0.0111
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0195
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0066 0.0634 0.1218
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.01
Brugia malayi 6-phosphofructokinase 0.0123 0.1288 0.247
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0051 0.0369
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Echinococcus multilocularis aminopeptidase N 0.0012 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0286 0.0286
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0286 0.0543
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0061 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0206
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0004 0.0007
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Schistosoma mansoni lipoxygenase 0.0021 0.0107 0.0209
Brugia malayi tailless protein 0.0017 0.0061 0.0111
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1735 0.8425
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0286 0.0543
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0569 0.2752
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0051 0.008
Echinococcus granulosus aminopeptidase N 0.0012 0.0004 0.0005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0614 0.0925
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.2059 1
Schistosoma mansoni rab6-interacting 0.0021 0.0107 0.0209
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0246 0.1181
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0614 0.2969
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Onchocerca volvulus 0.0036 0.0286 0.0475
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0023
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0017 0.0028
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0073 0.0139
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0286 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0286 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Brugia malayi conserved hypotetical protein 0.0017 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0397 0.0762
Onchocerca volvulus 0.0056 0.0512 0.0856
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0014 0.0027 0.0039
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0061 0.0116
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0061 0.0116
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0073 0.011
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0286 0.043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Brugia malayi CCR4 0.0016 0.0051 0.0091
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0073 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0061 0.0097
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.053 0.256
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0286 0.0475
Onchocerca volvulus 0.0018 0.0073 0.0117
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0246 0.0321
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0141 0.0212
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0061 0.0111
Brugia malayi Pre-SET motif family protein 0.0459 0.5203 1
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0051 0.0077
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Schistosoma mansoni chromobox protein 0.0082 0.0817 0.1636
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0633 0.0633
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0151
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0027 0.0112
Schistosoma mansoni synaptojanin 0.0016 0.0051 0.0095
Schistosoma mansoni cpg binding protein 0.0033 0.024 0.0476
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0803 0.1236
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Echinococcus granulosus Chromobox protein 3 0.0013 0.0017 0.0026
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0061 0.0061
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0803 0.1543
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0512 0.0984
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1735 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.2059 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0117 0.0225
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0051 0.023
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0039 0.0072
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0128 0.1351 0.271
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.053 0.4097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0061 0.0061
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0067 0.0067
Schistosoma mansoni zinc finger protein 0.0017 0.0061 0.0116
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0818
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0061 0.0092
Brugia malayi Pre-SET motif family protein 0.0066 0.0634 0.1212
Onchocerca volvulus 0.0018 0.0073 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0051 0.0593
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0246 0.1181
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0141 0.0276
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0286 0.0286
Brugia malayi Heterochromatin protein 1 0.0082 0.0817 0.1564
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0109 0.0109
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0073 0.014
Echinococcus multilocularis chromobox protein 1 0.0082 0.0817 0.0817
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0106 0.0205
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0073 0.0133
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Schistosoma mansoni hypothetical protein 0.0016 0.0051 0.0095
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0067 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Brugia malayi hypothetical protein 0.0021 0.0107 0.0199
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3378 0.6787
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0539 0.6136 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0397 0.0662
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0051 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0286 0.0549
Echinococcus granulosus nAChR subunit 0.0018 0.0073 0.011
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0038 0.0069
Brugia malayi hypothetical protein 0.0131 0.1383 0.2652
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0004 0.0007
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.2953 0.4449
Brugia malayi steroid hormone receptor 0.0036 0.0286 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0286 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.024 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0286 0.0543
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1288 0.2475
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.021 0.0396
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0151
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Echinococcus granulosus expressed protein 0.0401 0.4528 0.6822
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0051 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2969
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0109 0.1314
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0051 0.0369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0175 0.0264
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0195
Schistosoma mansoni DNA helicase recq1 0.0021 0.0109 0.0211
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0109 0.0109
Onchocerca volvulus 0.0016 0.0051 0.008
Schistosoma mansoni rab6-interacting 0.0021 0.0107 0.0209
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0397 0.0662
Echinococcus granulosus chromobox protein 1 0.0082 0.0817 0.1231
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0206
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0051 0.0077
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0073 0.011
Onchocerca volvulus 0.0014 0.0027 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0653 0.1256
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.01 0.0151
Brugia malayi intermediate filament protein 0.0056 0.0512 0.0978
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0067 0.0307
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0633 0.0633
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0017 0.0017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0286 0.0286
Brugia malayi MAP kinase sur-1 0.0057 0.053 0.1012
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Brugia malayi chromobox protein homolog 3 0.0046 0.0397 0.0756
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0051 0.0593
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0634 0.3066
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0107 0.0162
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0286 0.0286
Trichomonas vaginalis rotamase, putative 0.0036 0.0278 0.0463
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0633 0.1266
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0803 0.1537
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Onchocerca volvulus 0.0014 0.0027 0.0039
Schistosoma mansoni rotamase 0.0036 0.0278 0.0553
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0803 0.0803
Toxoplasma gondii subtilisin SUB12 0.0014 0.0027 0.0112
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0051 0.0457 0.0878
Echinococcus multilocularis cpg binding protein 0.0033 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0073 0.011
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0141 0.0141
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0107 0.1298
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0085 0.0164
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0269 0.0717
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0634 0.0955
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0061 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Brugia malayi hypothetical protein 0.0021 0.01 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0067 0.01
Brugia malayi hypothetical protein 0.0106 0.1097 0.2102
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.2549 0.2549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0051 0.0369
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0202
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.01 0.0151
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0286 0.0286
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0017 0.0171
Echinococcus multilocularis chromobox protein 2 0.0013 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0051 0.0369
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0073 0.0133
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.01
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0051 0.0098
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0017 0.0017
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0017 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.053 0.1058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0051 0.023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Echinococcus multilocularis lamin 0.0056 0.0512 0.0512
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0051 0.008
Schistosoma mansoni slit 0.0024 0.0141 0.0276
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.01 0.0186
Trypanosoma brucei protein kinase, putative 0.0057 0.053 0.4097
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0817 0.157
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0286 0.0543
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0286 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0286 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2804
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.01 0.0186
Brugia malayi hypothetical protein 0.0017 0.0061 0.0111
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.01 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis RUN 0.0021 0.0107 0.0107
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0061 0.0111
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0051 0.0095
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0051 0.0593
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0073 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.01 0.0195
Trichomonas vaginalis chromobox protein, putative 0.005 0.0437 0.0731
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0803 0.3889
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.053 0.0798
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.01 0.01
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0117 0.0553
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0117 0.1421
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0038 0.0057
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Echinococcus granulosus cpg binding protein 0.0033 0.024 0.0362
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0073 0.0133
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Echinococcus multilocularis musashi 0.0056 0.0512 0.0512
Echinococcus granulosus intermediate filament protein 0.0056 0.0512 0.0771

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 42 nM Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells ChEMBL. 9873445
IC50 (binding) = 42 nM Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells ChEMBL. 9873445

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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