Detailed information for compound 794914

Basic information

Technical information
  • TDR Targets ID: 794914
  • Name: 2-amino-1-(3-chloro-2-methylphenyl)-4-(4-chlo rophenyl)-5-oxo-4,6,7,8-tetrahydroquinoline-3 -carbonitrile
  • MW: 424.322 | Formula: C23H19Cl2N3O
  • H donors: 1 H acceptors: 2 LogP: 5.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)N(C2=C(C1c1ccc(cc1)Cl)C(=O)CCC2)c1cccc(c1C)Cl
  • InChi: 1S/C23H19Cl2N3O/c1-13-17(25)4-2-5-18(13)28-19-6-3-7-20(29)22(19)21(16(12-26)23(28)27)14-8-10-15(24)11-9-14/h2,4-5,8-11,21H,3,6-7,27H2,1H3
  • InChiKey: LTNFTJNMUKDULU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-1-(3-chloro-2-methyl-phenyl)-4-(4-chlorophenyl)-5-oxo-4,6,7,8-tetrahydroquinoline-3-carbonitrile
  • 2-amino-1-(3-chloro-2-methyl-phenyl)-4-(4-chlorophenyl)-5-keto-4,6,7,8-tetrahydroquinoline-3-carbonitrile
  • Oprea1_140418
  • AG-205/36868031
  • A1277/0058410

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0056 0.004
Echinococcus multilocularis chromobox protein 1 0.0076 0.0681 0.0868
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0163 0.0163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0288 0.0288
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0025 0.001
Schistosoma mansoni ap endonuclease 0.0081 0.0741 0.0741
Schistosoma mansoni tar DNA-binding protein 0.0147 0.1458 0.1458
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.1033 0.1033
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0147 0.0278
Leishmania major T-complex protein 1, beta subunit, putative 0.0028 0.0158 0.0302
Plasmodium falciparum heat shock protein 90 0.0067 0.0584 0.7797
Echinococcus granulosus sterol regulatory element binding protein 0.0095 0.0893 0.1138
Onchocerca volvulus 0.0146 0.1456 0.5587
Schistosoma mansoni chromobox protein 0.0076 0.0681 0.0681
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0444 0.5843
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0147 0.1702
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0765 0.2784
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0085 0.0109
Trypanosoma brucei C-8 sterol isomerase, putative 0.0415 0.4412 1
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Loa Loa (eye worm) solute carrier family 6 member 4 0.017 0.1719 0.1719
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0032
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0307 0.0307
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0025 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Entamoeba histolytica heat shock protein 90, putative 0.0067 0.0584 0.2467
Loa Loa (eye worm) RNA binding protein 0.0147 0.1458 0.1458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0313
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0433 0.0418
Schistosoma mansoni glutaminase 0.0922 1 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0029 0.0163 0.0207
Schistosoma mansoni kinase 0.0055 0.0448 0.0448
Echinococcus multilocularis serotonin transporter 0.017 0.1719 0.2191
Loa Loa (eye worm) beta-lactamase 0.004 0.0288 0.0288
Toxoplasma gondii thioredoxin reductase 0.0037 0.0248 0.3108
Loa Loa (eye worm) fli-1 protein 0.026 0.2706 0.2706
Loa Loa (eye worm) hypothetical protein 0.017 0.1719 0.1719
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Echinococcus multilocularis synaptojanin 1 0.0016 0.0025 0.0032
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.2682 1
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0028 0.0158 0.0584
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0288 0.099
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0298 0.0282
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0444 0.0953
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0288 0.0367
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0085 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1247 0.1247
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0025 0.0032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0741 1
Brugia malayi hypothetical protein 0.0035 0.0231 0.0231
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0211 0.0269
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0085 0.0109
Echinococcus multilocularis heat shock protein 90 0.0053 0.0433 0.0552
Onchocerca volvulus 0.003 0.0174 0.0578
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0444 0.5843
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0288 0.0288
Mycobacterium tuberculosis Conserved protein 0.004 0.0288 0.099
Echinococcus multilocularis protein dispatched 1 0.0109 0.1041 0.1327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0076 0.0115
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0163 0.0207
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0248 0.3108
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0147 0.0476
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0085 0.0109
Leishmania major heat shock protein, putative 0.0027 0.0147 0.0278
Trichomonas vaginalis esterase, putative 0.004 0.0288 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0076 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0288 0.0368
Loa Loa (eye worm) hypothetical protein 0.0146 0.1456 0.1456
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0741 0.0945
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0765 0.2784
Toxoplasma gondii hypothetical protein 0.0029 0.0163 0.1916
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0089 0.0114
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0076 0.006
Echinococcus multilocularis GA binding protein alpha chain 0.0086 0.0787 0.1003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.0163
Echinococcus multilocularis chromobox protein 1 0.0076 0.0681 0.0868
Brugia malayi glutathione reductase 0.0037 0.0248 0.0248
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0741 0.1632
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0025
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.017 0.1719 0.1719
Schistosoma mansoni gabp alpha 0.0086 0.0787 0.0787
Loa Loa (eye worm) heat shock protein 90 0.0067 0.0584 0.0584
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Treponema pallidum sodium- and chloride- dependent transporter 0.017 0.1719 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0741 0.1672
Echinococcus granulosus expressed conserved protein 0.0208 0.214 0.2728
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.0163
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0158 0.0158
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0076 0.0097
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0163 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0288 0.0214
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Plasmodium vivax endoplasmin, putative 0.0067 0.0584 0.7797
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0025 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0288 0.06
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Giardia lamblia Heat shock protein HSP 90-alpha 0.0067 0.0584 0.554
Loa Loa (eye worm) hypothetical protein 0.0415 0.4412 0.4412
Mycobacterium tuberculosis Probable reductase 0.0084 0.0765 0.2784
Echinococcus multilocularis heat shock protein 90 0.0067 0.0584 0.0744
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0085 0.007
Giardia lamblia Kinase, PLK 0.0108 0.1033 1
Schistosoma mansoni ets-related 0.026 0.2706 0.2706
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Plasmodium falciparum transporter, putative 0.0029 0.0163 0.1916
Brugia malayi heat shock protein 90 0.0067 0.0584 0.0584
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0248 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.1519 0.1937
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0147 0.0325
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Echinococcus granulosus chromobox protein 1 0.0076 0.0681 0.0868
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0248 0.0838
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0021 0.0005
Loa Loa (eye worm) glutaminase 0.0922 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0025 0.0025
Onchocerca volvulus Alhambra homolog 0.0033 0.0211 0.0725
Trypanosoma brucei unspecified product 0.0021 0.0076 0.0163
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.1916
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0248 0.0507
Brugia malayi beta-lactamase 0.004 0.0288 0.0288
Schistosoma mansoni cpg binding protein 0.0032 0.0192 0.0192
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0868 1
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0085 0.0109
Loa Loa (eye worm) hypothetical protein 0.0222 0.2288 0.2288
Schistosoma mansoni tar DNA-binding protein 0.0147 0.1458 0.1458
Plasmodium falciparum amino acid transporter, putative 0.0029 0.0163 0.1916
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1033 0.2297
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0163 0.0207
Leishmania major trypanothione reductase 0.0037 0.0248 0.0507
Loa Loa (eye worm) hypothetical protein 0.0057 0.0473 0.0473
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0025 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0741 0.0727
Loa Loa (eye worm) norepinephrine transporter 0.017 0.1719 0.1719
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0433 0.0418
Trypanosoma brucei heat shock protein 90, putative 0.0067 0.0584 0.1314
Schistosoma mansoni hypothetical protein 0.0033 0.0211 0.0211
Onchocerca volvulus 0.004 0.0288 0.1027
Trypanosoma brucei trypanothione reductase 0.0037 0.0248 0.0553
Schistosoma mansoni synaptojanin 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0211 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0176 0.0161
Plasmodium falciparum endoplasmin, putative 0.0041 0.0298 0.3805
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0065 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0163 0.1916
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0163 0.0207
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0741 0.1632
Onchocerca volvulus 0.004 0.0288 0.1027
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0085 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0089 0.0089
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0147 0.1702
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0053 0.0433 0.0552
Loa Loa (eye worm) TAR-binding protein 0.0147 0.1458 0.1458
Trypanosoma cruzi heat shock protein 90, putative 0.0053 0.0433 0.0929
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0147 0.1702
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0053 0.0433 0.1534
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0085 0.0109
Mycobacterium ulcerans heat shock protein 90 0.0053 0.0433 0.036
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0085 0.0085
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0741 0.2694
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Brugia malayi Heterochromatin protein 1 0.0076 0.0681 0.0681
Onchocerca volvulus 0.004 0.0288 0.1027
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0085 0.0085
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0089 0.0114
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0056 0.004
Onchocerca volvulus 0.0029 0.0163 0.0535
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0868 0.317
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0095 0.0893 0.0893
Schistosoma mansoni cript-related 0.0016 0.0025 0.0025
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0444 0.5843
Schistosoma mansoni endoplasmin 0.0067 0.0584 0.0584
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0085 0.0085
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0163 0.0163
Mycobacterium ulcerans hypothetical protein 0.004 0.0288 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0868 0.317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Echinococcus granulosus heat shock protein 0.0067 0.0584 0.0744
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0288 0.06
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0158 0.0158
Trichomonas vaginalis glutaminase, putative 0.0922 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0313 0.0298
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.017 0.1719 0.1719
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0085 0.0085
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0086 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0076 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0307 0.0307
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0076 0.0191
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0444 0.0997
Onchocerca volvulus 0.017 0.1719 0.6612
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0147 0.0188
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0288 0.099
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0025 0.0048
Plasmodium vivax amine transporter, putative 0.0029 0.0163 0.1916
Schistosoma mansoni hypothetical protein 0.0092 0.0855 0.0855
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0288 0.0273
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.1033 0.2297
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0085 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0025 0.001
Onchocerca volvulus 0.0033 0.0212 0.0728
Echinococcus granulosus cpg binding protein 0.0032 0.0192 0.0245
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0085 0.0085
Leishmania major DNA polymerase kappa, putative 0.0021 0.0076 0.0115
Brugia malayi MH2 domain containing protein 0.0127 0.1247 0.1247
Trypanosoma brucei polo-like protein kinase 0.0108 0.1033 0.2334
Echinococcus granulosus Niemann Pick C1 protein 0.0317 0.3337 0.4253
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0076 0.0097
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0681 0.0681
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1033 0.1033
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Schistosoma mansoni tar DNA-binding protein 0.0147 0.1458 0.1458
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0076 0.0191
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0741 0.067
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0741 0.0741
Echinococcus granulosus dnaJ subfamily B 0.0426 0.4533 0.5778
Trypanosoma cruzi heat shock protein 85, putative 0.0067 0.0584 0.1272
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0025 0.0032
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0025
Loa Loa (eye worm) endoplasmin 0.0067 0.0584 0.0584
Echinococcus granulosus dna polymerase kappa 0.0021 0.0076 0.0097
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0076 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Loa Loa (eye worm) hypothetical protein 0.0052 0.0414 0.0414
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0025 0.0032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0288 0.099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1519 0.1519
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0288 0.099
Mycobacterium tuberculosis Conserved protein 0.004 0.0288 0.099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.1519 0.1937
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.0444
Toxoplasma gondii ABC1 family protein 0.004 0.0288 0.3675
Brugia malayi beta-lactamase family protein 0.004 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0726 0.7846 0.7846
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0085 0.0085
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1033 0.2297
Mycobacterium ulcerans lipase LipD 0.004 0.0288 0.0214
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0025 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Loa Loa (eye worm) glutathione reductase 0.0037 0.0248 0.0248
Schistosoma mansoni sodium/chloride dependent transporter 0.017 0.1719 0.1719
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0085 0.0085
Plasmodium vivax hypothetical protein, conserved 0.004 0.0288 0.3675
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.1916
Loa Loa (eye worm) hypothetical protein 0.0212 0.2179 0.2179
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.1033 0.3933
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0349 0.0334
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0085 0.0109
Brugia malayi CXXC zinc finger family protein 0.003 0.0174 0.0174
Giardia lamblia DINP protein human, muc B family 0.0021 0.0076 0.0503
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0444 0.0953
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0085 0.0109
Leishmania major hypothetical protein, conserved 0.004 0.0288 0.06
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0025 0.0048
Brugia malayi Fli-1 protein 0.026 0.2706 0.2706
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0076 0.0115
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0288 0.0214
Toxoplasma gondii exonuclease III APE 0.0081 0.0741 1
Echinococcus multilocularis vesicular acetylcholine transporter 0.0249 0.2587 0.3297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.1519 0.1937
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0076 0.006
Brugia malayi hypothetical protein 0.0054 0.0444 0.0444
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0024 0.0113 0.0113
Toxoplasma gondii heat shock protein HSP90 0.0067 0.0584 0.7797
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0225 0.2326 0.2326
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0288 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0025 0.0032
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0029 0.0163 0.0207
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0415 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0288 0.0288
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0741 0.7105
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0868 0.317
Brugia malayi PHD-finger family protein 0.0033 0.0211 0.0211
Echinococcus multilocularis dna polymerase eta 0.0021 0.0076 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1247 0.1247
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0288 0.0273
Echinococcus granulosus peregrin 0.0033 0.0211 0.0269
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0025 0.0048
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0163 0.0207
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0085 0.0085
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0076 0.0163
Schistosoma mansoni hypothetical protein 0.0092 0.0855 0.0855
Trypanosoma cruzi heat shock protein 90, putative 0.0067 0.0584 0.1272
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Schistosoma mansoni synaptojanin 0.0016 0.0025 0.0025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1046 0.1333
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0414 0.0414
Echinococcus granulosus heat shock protein 90 0.0067 0.0584 0.0744
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0349 0.0334
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0158 0.0158
Echinococcus granulosus GPCR family 2 0.0016 0.0025 0.0032
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.1916
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0025 0.0048
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0085 0.0085
Schistosoma mansoni heat shock protein 0.0027 0.0147 0.0147
Schistosoma mansoni cpg binding protein 0.0032 0.0192 0.0192
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0025 0.001
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0433 0.0418
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Schistosoma mansoni patched 1 0.0095 0.0893 0.0893
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0025 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0288 0.0288
Loa Loa (eye worm) T-complex protein 1 0.0028 0.0158 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0147 0.1458 0.1458
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Schistosoma mansoni vesicular acetylcholine transporter 0.0249 0.2587 0.2587
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0741 1
Onchocerca volvulus 0.0029 0.0163 0.0535
Loa Loa (eye worm) hypothetical protein 0.017 0.1719 0.1719
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Giardia lamblia Grp94/Hsp90 0.0053 0.0433 0.4046
Echinococcus multilocularis protein patched 0.0095 0.0893 0.1138
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.1033 0.1033
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0288 0.0273
Brugia malayi CCR4 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0117 0.1129 0.1129
Schistosoma mansoni nocturnin 0.0016 0.0025 0.0025
Echinococcus multilocularis peregrin 0.0033 0.0211 0.0269
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0025 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0028 0.0158 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0076 0.0224
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0085 0.0085
Echinococcus granulosus tar DNA binding protein 0.0147 0.1458 0.1858
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0893 0.0879
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0602 0.0602
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0147 0.1458 0.1458
Entamoeba histolytica heat shock protein 90, putative 0.0067 0.0584 0.2467
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0765 0.8226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0234
Schistosoma mansoni endoplasmin 0.0067 0.0584 0.0584
Schistosoma mansoni hypothetical protein 0.0092 0.0855 0.0855
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Echinococcus multilocularis GPCR, family 2 0.0016 0.0025 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.1519 0.1937
Brugia malayi Thioredoxin reductase 0.0037 0.0248 0.0248
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0433 0.0418
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0025 0.0032
Echinococcus multilocularis sterol regulatory element binding protein 0.0095 0.0893 0.1138
Toxoplasma gondii t-complex protein beta subunit 0.0028 0.0158 0.1848
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0414 0.0414
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0444 0.5843
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0029 0.0163 0.0207
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0085 0.0109
Loa Loa (eye worm) hypothetical protein 0.0073 0.065 0.065
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0025 0.0032
Trypanosoma brucei Heat shock protein 83, putative 0.0067 0.0584 0.1314
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0288 0.0645
Giardia lamblia TCP-1 chaperonin subunit beta 0.0028 0.0158 0.1313
Brugia malayi CHE-14 protein 0.0095 0.0893 0.0893
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0166 0.0166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0076 0.0115
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0158 0.0158
Brugia malayi TAR-binding protein 0.0147 0.1458 0.1458
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0085 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Echinococcus granulosus heat shock protein 90 0.0053 0.0433 0.0552
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0076 0.0115
Mycobacterium ulcerans beta-lactamase 0.004 0.0288 0.0214
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0158 0.0158
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0032
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0089 0.0089
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0147 0.0188
Loa Loa (eye worm) glutaminase 2 0.0922 1 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0147 0.0538
Schistosoma mansoni heat shock protein 0.0067 0.0584 0.0584
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0433 0.0418
Giardia lamblia Heat shock protein HSP 90-alpha 0.0053 0.0433 0.4046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0765 0.2784
Plasmodium falciparum phd finger protein, putative 0.0033 0.0211 0.2595
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0022 0.0085 0.0266
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.0163
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0076 0.0076
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0211 0.0269
Toxoplasma gondii heat shock protein 90, putative 0.0067 0.0584 0.7797
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0234 0.0234
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0799 0.0799
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Echinococcus granulosus serotonin transporter 0.017 0.1719 0.2191
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0313 0.1124
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0253 0.0323
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0163 0.0163
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0281 0.0582
Loa Loa (eye worm) hypothetical protein 0.004 0.0288 0.0288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0288 0.099
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0076 0.0163
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0147 0.1702
Echinococcus multilocularis heat shock protein 0.0067 0.0584 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1519 0.1519
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0025 0.0032
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1046 0.1333
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0085 0.0085
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0211 0.2595
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0085 0.0109
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0741 0.0945
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Echinococcus granulosus endoplasmin 0.0053 0.0433 0.0552
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1519 0.1519
Trichomonas vaginalis endoplasmin, putative 0.0041 0.0298 0.0282
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0085 0.0109
Giardia lamblia PHD finger protein 15 0.0033 0.0211 0.1844
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0025 0.0048
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0211 0.0211
Echinococcus multilocularis cpg binding protein 0.0032 0.0192 0.0245
Schistosoma mansoni heat shock protein 0.0067 0.0584 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0085 0.0085
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0741 0.4227
Leishmania major C-8 sterol isomerase-like protein 0.0415 0.4412 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0415 0.4412 0.4412
Plasmodium vivax heat shock protein 86, putative 0.0067 0.0584 0.7797
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Trypanosoma cruzi heat shock protein 85, putative 0.0067 0.0584 0.1272
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0147 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Echinococcus multilocularis tar DNA binding protein 0.0147 0.1458 0.1858
Brugia malayi hypothetical protein 0.0022 0.0085 0.0085
Echinococcus granulosus chromobox protein 1 0.0076 0.0681 0.0868
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0085 0.0085
Brugia malayi Ets-domain containing protein 0.0086 0.0787 0.0787
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.4533 0.5778
Echinococcus multilocularis expressed conserved protein 0.0208 0.214 0.2728
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0163 0.0163
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0025 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1033 0.1019
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0085 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0089 0.0089
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0113 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0076 0.0076
Treponema pallidum heat shock protein 90 0.0053 0.0433 0.2407
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0249 0.2587 0.2587
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Plasmodium vivax glutathione reductase, putative 0.0037 0.0248 0.3108
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0741 0.1632
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0288 0.0368
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0029 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Echinococcus granulosus vesicular acetylcholine transporter 0.0249 0.2587 0.3297
Brugia malayi Sodium:neurotransmitter symporter family protein 0.017 0.1719 0.1719
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0765 0.2784
Plasmodium falciparum T-complex protein 1 subunit beta 0.0028 0.0158 0.1848
Trypanosoma cruzi heat shock protein 85, putative 0.0067 0.0584 0.1272
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0249 0.2587 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0085 0.0109
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0089 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.1519 0.1519
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0085 0.0109
Schistosoma mansoni hypothetical protein 0.0092 0.0855 0.0855
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0741 0.0741
Entamoeba histolytica hypothetical protein 0.0022 0.0085 0.0266
Trichomonas vaginalis heat shock protein, putative 0.0067 0.0584 0.0569
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0174 0.0174
Schistosoma mansoni DNA polymerase eta 0.0021 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0426 0.4533 0.4533
Entamoeba histolytica hypothetical protein 0.0022 0.0085 0.0266
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0147 0.1702
Brugia malayi Niemann-Pick C1 protein precursor 0.0222 0.2288 0.2288
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.0234
Brugia malayi jmjC domain containing protein 0.0109 0.1046 0.1046
Leishmania major DNA polymerase eta, putative 0.0021 0.0076 0.0115
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0029 0.0163 0.0207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0076 0.0097
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0288 0.0273
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0288 0.099
Echinococcus granulosus Protein patched homolog 1 0.0095 0.0893 0.1138
Echinococcus granulosus GA binding protein alpha chain 0.0086 0.0787 0.1003
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0028 0.0158 0.0201
Mycobacterium tuberculosis Conserved protein 0.004 0.0288 0.099
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0085 0.0085
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.1033 0.1316
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0029 0.0163 0.5
Brugia malayi chromobox protein homolog 3 0.0043 0.0313 0.0313
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0741 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.1033 0.1316
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0028 0.0158 0.0302
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0163 0.0207
Echinococcus granulosus dna polymerase eta 0.0021 0.0076 0.0097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0113 0.0144
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0028 0.0158 0.1848
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0025 0.0025
Trypanosoma cruzi Heat shock protein 83, putative 0.0067 0.0584 0.1272
Echinococcus granulosus expressed protein 0.0426 0.4541 0.5787
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0085 0.0085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0095 0.0893 0.0893
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0025 0.0048
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0025 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0765 0.2784
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0025 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0222 0.2288 0.2916
Onchocerca volvulus 0.0029 0.0163 0.0535
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0681 0.0666
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.1519 0.1519
Toxoplasma gondii hypothetical protein 0.0029 0.0163 0.1916
Brugia malayi RNA recognition motif domain containing protein 0.0147 0.1458 0.1458
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0025 0.001
Schistosoma mansoni chromobox protein 0.0076 0.0681 0.0681
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0741 0.3163
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0025 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0543 0.0543
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0222 0.2288 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0053 0.0433 0.0929
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0053 0.0433 0.2495
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0163 0.0163
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0025 0.001
Brugia malayi hypothetical protein 0.0022 0.0085 0.0085
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Brugia malayi RNA binding protein 0.0147 0.1458 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0313 0.0298
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0468 0.6185
Echinococcus multilocularis geminin 0.0726 0.7846 1
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0741 0.0727
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0025 0.0025
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0307 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0085 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0726 0.7846 0.7846
Trypanosoma brucei heat shock protein, putative 0.0067 0.0584 0.1314
Loa Loa (eye worm) hypothetical protein 0.0033 0.0212 0.0212
Brugia malayi Endoplasmin precursor 0.0067 0.0584 0.0584
Brugia malayi PXA domain containing protein 0.0022 0.0085 0.0085
Echinococcus granulosus geminin 0.0726 0.7846 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0029 0.0163 0.0163
Plasmodium falciparum thioredoxin reductase 0.0037 0.0248 0.3108
Brugia malayi vesicular acetylcholine transporter unc-17 0.0249 0.2587 0.2587
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0211 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0414 0.0414
Brugia malayi hypothetical protein 0.0029 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0681 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0307 0.0307
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0085 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0089 0.0089
Brugia malayi Bromodomain containing protein 0.0033 0.0211 0.0211
Echinococcus multilocularis expressed protein 0.0426 0.4541 0.5787
Echinococcus multilocularis Niemann Pick C1 protein 0.0222 0.2288 0.2916
Plasmodium falciparum glutathione reductase 0.0037 0.0248 0.3108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0076 0.0076
Loa Loa (eye worm) serotonin transporter b 0.017 0.1719 0.1719
Plasmodium vivax heat shock protein, putative 0.0027 0.0147 0.1702
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.1033 0.4452
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Trichomonas vaginalis chaperonin, putative 0.0028 0.0158 0.0142
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0433 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0176 0.0161
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0085 0.0109
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0025 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0317 0.3337 0.4253
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0021 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0211 0.2595
Schistosoma mansoni cpg binding protein 0.003 0.0174 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0211 0.2595
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0056 0.004
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0028 0.0158 0.0348
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Echinococcus granulosus synaptojanin 1 0.0016 0.0025 0.0032
Echinococcus multilocularis endoplasmin 0.0053 0.0433 0.0552
Brugia malayi beta-lactamase family protein 0.004 0.0288 0.0288
Schistosoma mansoni ap endonuclease 0.0081 0.0741 0.0741
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0076 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0147 0.1458 0.1458
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0355 0.0452
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0076 0.0076
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Trypanosoma brucei heat shock protein 90, putative 0.0067 0.0584 0.1314
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0076 0.0163
Brugia malayi Hsp90 protein 0.0027 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0025 0.001
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0029 0.0163 0.0207
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0288 0.099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0253 0.0323
Brugia malayi PXA domain containing protein 0.0022 0.0085 0.0085
Brugia malayi hypothetical protein 0.0146 0.1456 0.1456
Mycobacterium ulcerans glutaminase 0.0922 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0349 0.1263
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0028 0.0158 0.0201
Leishmania major hypothetical protein, conserved 0.0054 0.0444 0.0953
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0025 0.001
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0163
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0355 0.0452
Brugia malayi jmjC domain containing protein 0.0042 0.0307 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0076 0.0163
Brugia malayi Ets-domain containing protein 0.0086 0.0787 0.0787
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272
Leishmania major heat shock protein 83-1 0.0067 0.0584 0.1272

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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