Detailed information for compound 79855

Basic information

Technical information
  • TDR Targets ID: 79855
  • Name: 4-[2-(3-chloro-4-fluorophenyl)-4,5-difluoroph enyl]benzenesulfonamide
  • MW: 397.799 | Formula: C18H11ClF3NO2S
  • H donors: 1 H acceptors: 2 LogP: 4.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(c2ccc(c(c2)Cl)F)c(cc1F)c1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C18H11ClF3NO2S/c19-15-7-11(3-6-16(15)20)14-9-18(22)17(21)8-13(14)10-1-4-12(5-2-10)26(23,24)25/h1-9H,(H2,23,24,25)
  • InChiKey: QZOXMKNWQZCVDE-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[2-(3-chloro-4-fluoro-phenyl)-4,5-difluoro-phenyl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0136 0.2656 0.2577
Schistosoma mansoni RAR-like nuclear receptor 0.0106 0.199 0.252
Echinococcus multilocularis notch 0.0021 0.0107 0.0103
Brugia malayi hypothetical protein 0.0025 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Schistosoma mansoni notch 0.0021 0.011 0.0106
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0066 0.005
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0757 0.1026
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0285 0.0285
Echinococcus granulosus jun protein 0.0174 0.3476 0.4851
Brugia malayi Muscle positioning protein 4 0.0021 0.0107 0.0107
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0027 0.0027
Echinococcus granulosus protein jagged 1 0.0021 0.0107 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2774 0.3525
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.2373 1
Brugia malayi Animal haem peroxidase family protein 0.0063 0.1053 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0106 0.199 0.1937
Loa Loa (eye worm) hypothetical protein 0.01 0.1856 0.1802
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0498 0.0498
Echinococcus granulosus geminin 0.0171 0.3408 0.4755
Brugia malayi protein kinase C II. 0.0033 0.0383 0.0383
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Onchocerca volvulus Peroxidase homolog 0.0063 0.1053 0.0956
Echinococcus multilocularis protein jagged 2 0.0021 0.0107 0.0103
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0019 0.0066 0.005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0727 0.0899
Brugia malayi ecdysteroid receptor 0.0106 0.199 0.199
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0498 0.419
Schistosoma mansoni hypothetical protein 0.0022 0.0137 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1856 0.2348
Loa Loa (eye worm) hypothetical protein 0.01 0.1856 0.1802
Echinococcus multilocularis protein jagged 1 0.0021 0.0107 0.0103
Schistosoma mansoni retinoic acid receptor RXR 0.0106 0.199 0.252
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0106 0.199 0.199
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Schistosoma mansoni lozenge 0.0059 0.0953 0.1188
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0757 0.0695
Plasmodium falciparum thioredoxin reductase 0.0049 0.0727 1
Onchocerca volvulus Peroxidase homolog 0.0063 0.1053 0.0956
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0498 0.666
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.21 0.8837
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0106 0.199 0.199
Brugia malayi nuclear receptor NHR-67 0.005 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Schistosoma mansoni notch 0.0021 0.0107 0.0103
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0106 0.199 0.199
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0137 0.0471
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0498 0.673
Onchocerca volvulus 0.0106 0.199 0.1904
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0137 0.1561
Brugia malayi Protein kinase c protein 2 0.0053 0.0823 0.0823
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0497 0.0603
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0498 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0019 0.0066 0.0347
Brugia malayi Protein kinase domain containing protein 0.0019 0.0066 0.0066
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0107 0.000000019679
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.1053 0.0993
Schistosoma mansoni hypothetical protein 0.0265 0.5485 0.7004
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.199 0.199
Loa Loa (eye worm) hypothetical protein 0.047 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0727 0.6226
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0207 0.2573
Onchocerca volvulus 0.0063 0.1053 0.0956
Echinococcus granulosus neural cadherin 0.0021 0.0107 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0137 0.0471
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0735 0.0673
Loa Loa (eye worm) hypothetical protein 0.0056 0.0889 0.0828
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0757 0.0937
Loa Loa (eye worm) hypothetical protein 0.0056 0.0889 0.0828
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0106 0.199 0.252
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0285 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0137 0.0471
Schistosoma mansoni notch 0.0021 0.0107 0.0103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0889 0.1106
Brugia malayi Trypsin family protein 0.01 0.1856 0.1856
Echinococcus multilocularis peroxidasin 0.0063 0.1053 0.1316
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.2774 0.2774
Echinococcus granulosus protein kinase c iota type 0.0032 0.0356 0.0463
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0018 0.0057 0.0641
Onchocerca volvulus 0.0134 0.2601 0.2521
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0137 0.1561
Schistosoma mansoni intermediate filament proteins 0.0029 0.0285 0.0332
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.1053 0.0993
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0757 0.0937
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1135 0.1135
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0137 0.0471
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0207 0.1602
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0106 0.199 0.252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0106 0.199 0.252
Echinococcus granulosus slit 2 protein 0.0021 0.0107 0.0113
Trypanosoma brucei cytochrome P450, putative 0.0049 0.0735 0.6291
Loa Loa (eye worm) RNA binding protein 0.0067 0.1135 0.1076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0757 0.1026
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1224 0.1537
Echinococcus multilocularis lamin dm0 0.0029 0.0285 0.0332
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.011 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.2373 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1135 0.1076
Echinococcus multilocularis ecdysone induced protein 78C 0.0106 0.199 0.252
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0207 0.1602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0246 0.5065 0.5065
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0498 0.0435
Loa Loa (eye worm) hypothetical protein 0.0147 0.2891 0.2844
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0757 0.0937
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Onchocerca volvulus 0.0029 0.0285 0.018
Onchocerca volvulus Peroxidasin homolog 0.0063 0.1053 0.0956
Trypanosoma brucei trypanothione reductase 0.0049 0.0727 0.6226
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0137 0.0155
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1135 0.1076
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0107 0.0107
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.5065 0.5032
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0889 0.0828
Brugia malayi Blistered cuticle protein 3 0.0063 0.1053 0.1053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0106 0.199 0.252
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0106 0.199 0.199
Echinococcus multilocularis jun protein 0.0174 0.3476 0.4426
Schistosoma mansoni hypothetical protein 0.0171 0.3408 0.4339
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0137 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.005
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0137 0.0471
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.199 0.199
Brugia malayi nuclear receptor NHR-88 0.0106 0.199 0.199
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1135 0.1422
Echinococcus granulosus Protein kinase C brain isozyme 0.0071 0.1224 0.1684
Brugia malayi TAR-binding protein 0.0067 0.1135 0.1135
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.1053 0.0993
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2774 0.3862
Loa Loa (eye worm) hypothetical protein 0.0056 0.0889 0.0828
Echinococcus granulosus FTZ F1 alpha 0.0106 0.199 0.2761
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Schistosoma mansoni hypothetical protein 0.0141 0.2761 0.3508
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi Cytochrome P450 family protein 0.0061 0.1002 0.1002
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0107 0.0113
Brugia malayi hypothetical protein 0.0056 0.0889 0.0889
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0137 0.0471
Echinococcus multilocularis protein kinase c iota type 0.0032 0.0356 0.0423
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0137 0.1561
Brugia malayi conserved hypotetical protein 0.005 0.0757 0.0757
Brugia malayi Nuclear hormone receptor E75 0.005 0.0757 0.0757
Onchocerca volvulus Peroxidasin homolog 0.0063 0.1053 0.0956
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1135 0.1422
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0106 0.199 0.1937
Brugia malayi Cadherin domain containing protein 0.0021 0.0107 0.0107
Brugia malayi Thioredoxin reductase 0.0049 0.0727 0.0727
Echinococcus multilocularis FTZ F1 alpha 0.0106 0.199 0.252
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0019 0.0066 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.199 0.252
Brugia malayi Cytochrome P450 family protein 0.0049 0.0735 0.0735
Echinococcus multilocularis geminin 0.0171 0.3408 0.4339
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1135 0.1422
Brugia malayi nuclear receptor RXR 0.005 0.0757 0.0757
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0137 0.1561
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0107 0.0107
Brugia malayi ecdysone receptor 0.005 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0498 0.419
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Mycobacterium tuberculosis Probable reductase 0.0111 0.21 0.8837
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Brugia malayi steroid hormone receptor 0.0106 0.199 0.199
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0107 0.1142
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0496 0.0602
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Echinococcus granulosus protein jagged 1 0.0021 0.0107 0.0113
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0498 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0106 0.199 0.199
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0757 0.0937
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.2774 0.2726
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0137 0.1561
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0757 0.0695
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0137 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.199 0.199
Entamoeba histolytica hypothetical protein 0.0038 0.0496 0.3958
Schistosoma mansoni nuclear receptor 0.005 0.0757 0.0937
Echinococcus granulosus lamin 0.0029 0.0285 0.0363
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0107 0.0103
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0174 0.3476 0.4426
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0019 0.0066 0.0055
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0107 0.0107
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0038 0.0497 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2774 0.3525
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1152 0.1152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.199 0.252
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0727 0.2985
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.1375 0.1896
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0107 0.0113
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0757 0.1026
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0137 0.0982
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0106 0.199 0.2761
Echinococcus granulosus protein kinase c epsilon type 0.0033 0.0383 0.0501
Echinococcus multilocularis fibropellin Ia 0.0021 0.0107 0.0103
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0498 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0498 0.419
Brugia malayi nuclear hormone receptor 0.0106 0.199 0.199
Schistosoma mansoni notch 0.0021 0.0107 0.0103
Echinococcus granulosus intermediate filament protein 0.0029 0.0285 0.0363
Schistosoma mansoni nuclear hormone receptor 0.005 0.0757 0.0937
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0137 0.1577
Entamoeba histolytica hypothetical protein 0.0038 0.0496 0.3958
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0137 0.0471
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0107 0.0103
Onchocerca volvulus 0.0093 0.1713 0.1623
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1135 0.1422
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0137 0.1561
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0106 0.199 0.2761
Schistosoma mansoni lamin 0.0029 0.0285 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0106 0.199 0.1937
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0498 0.0663
Brugia malayi Protein kinase domain containing protein 0.0019 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Schistosoma mansoni hypothetical protein 0.0171 0.3408 0.4339
Echinococcus granulosus lamin dm0 0.0029 0.0285 0.0363
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Entamoeba histolytica hypothetical protein 0.0038 0.0496 0.3958
Schistosoma mansoni hypothetical protein 0.0038 0.0496 0.0602
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0735 1
Leishmania major cytochrome p450-like protein 0.0022 0.0137 0.0982
Toxoplasma gondii exonuclease III APE 0.0038 0.0498 0.673
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1152 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0498 0.673
Leishmania major cytochrome p450-like protein 0.0022 0.0137 0.0982
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0106 0.199 0.252
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0137 0.0471
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0757 0.0937
Onchocerca volvulus 0.0029 0.0285 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0727 0.0666
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0727 0.0985
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0757 0.1026
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0137 0.1561
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0757 0.0757
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0735 0.0673
Schistosoma mansoni notch 0.0021 0.0107 0.0103
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0889 0.1212
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0498 0.2009
Brugia malayi Peroxidasin 0.0063 0.1053 0.1053
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.005
Loa Loa (eye worm) Notch2 0.0021 0.0107 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2774 0.3862
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.199 0.199
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.199 0.199
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0106 0.199 0.252
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0497 0.0661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0106 0.199 0.1937
Echinococcus multilocularis serine threonine protein kinase 0.0058 0.0934 0.1164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.199 0.2761
Echinococcus multilocularis musashi 0.0029 0.0285 0.0332
Loa Loa (eye worm) notch protein 0.0021 0.0107 0.0041
Brugia malayi notch-like transmembrane receptor 0.0021 0.0107 0.0107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0498 0.419
Loa Loa (eye worm) DR-78 0.005 0.0757 0.0695
Brugia malayi RNA binding protein 0.0067 0.1135 0.1135
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0027 0.0253 0.0188
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0757 0.0695
Toxoplasma gondii AGC kinase 0.0019 0.0066 0.0558
Onchocerca volvulus Dual oxidase homolog 0.0063 0.1053 0.0956
Schistosoma mansoni serine/threonine kinase 0.0019 0.0066 0.005
Schistosoma mansoni nuclear hormone receptor 0.0106 0.199 0.252
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0137 0.0471
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0056 0.0889 0.0828
Brugia malayi Hr1 repeat family protein 0.0019 0.0066 0.0066
Schistosoma mansoni ap endonuclease 0.0038 0.0498 0.0605
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0137 0.0471
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0137 0.1561
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0497 0.0603
Echinococcus granulosus fibropellin Ia 0.0021 0.0107 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi hypothetical protein 0.005 0.0757 0.0757
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.2373 1
Brugia malayi hypothetical protein 0.0063 0.1053 0.1053
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0033 0.0383 0.0319
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0106 0.199 0.1904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0106 0.199 0.1937
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0757 0.0937
Onchocerca volvulus 0.005 0.0751 0.0651
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1152 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1152 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2774 0.3525
Schistosoma mansoni slit 0.0021 0.0107 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0383 0.0457
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0522 0.0696
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0889 0.1106
Schistosoma mansoni nuclear hormone receptor 0.005 0.0757 0.0937
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0751 0.0929
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0137 0.1561
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0207 0.2573
Leishmania major trypanothione reductase 0.0049 0.0727 0.6226
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0735 0.0673
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0107 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0498 1
Schistosoma mansoni nuclear receptor 0.005 0.0757 0.0937
Schistosoma mansoni peroxidasin 0.0063 0.1053 0.1316
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi p70 ribosomal S6 kinase beta 0.0019 0.0066 0.0066
Echinococcus granulosus peroxidasin 0.0063 0.1053 0.1442
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0889 0.1106
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.21 0.878
Loa Loa (eye worm) cytochrome P450 0.0022 0.0137 0.0072
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0134 0.2601 0.2552
Brugia malayi Animal haem peroxidase family protein 0.0063 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0106 0.199 0.252
Brugia malayi hypothetical protein 0.0136 0.2656 0.2656
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0019 0.0066 0.005
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.1375 0.173
Brugia malayi glutathione reductase 0.0049 0.0727 0.0727
Echinococcus multilocularis Protein lozenge 0.0059 0.0953 0.1188
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.5485 0.7004
Echinococcus granulosus delta-like protein 1 0.0021 0.0107 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0137 0.0982
Onchocerca volvulus 0.005 0.0757 0.0657
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.199 0.199
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1152 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi Cytochrome P450 family protein 0.0022 0.0137 0.0137
Plasmodium vivax glutathione reductase, putative 0.0049 0.0727 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.21 0.8837
Schistosoma mansoni septate junction protein 0.0021 0.0107 0.0103
Echinococcus multilocularis serine:threonine protein kinase 38 0.0019 0.0066 0.005
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0019 0.0066 0.0055
Brugia malayi photoreceptor-specific nuclear receptor 0.0106 0.199 0.199
Schistosoma mansoni jun-related protein 0.0141 0.2761 0.3508
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.1053 0.0993
Plasmodium falciparum glutathione reductase 0.0049 0.0727 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Brugia malayi Animal haem peroxidase family protein 0.0063 0.1053 0.1053
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0103
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0066 0.005
Brugia malayi bZIP transcription factor family protein 0.0174 0.3476 0.3476
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Loa Loa (eye worm) hypothetical protein 0.0134 0.2601 0.2552
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.199 0.2761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.005
Onchocerca volvulus Bile acid receptor homolog 0.0106 0.199 0.1904
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0137 0.0982
Loa Loa (eye worm) hypothetical protein 0.0056 0.0889 0.0828
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Brugia malayi Animal haem peroxidase family protein 0.0063 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0107 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.199 0.199
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0019 0.0066 0.005
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0207 0.1602
Onchocerca volvulus 0.0063 0.1053 0.0956
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0727 1
Schistosoma mansoni atypical protein kinase C 0.0032 0.0356 0.0423
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Schistosoma mansoni peroxidasin 0.0063 0.1053 0.1316
Loa Loa (eye worm) steroid hormone receptor 0.0106 0.199 0.1937
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0137 0.0982
Echinococcus multilocularis tumor protein p63 0.034 0.7139 0.9126
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0498 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0106 0.199 0.1904
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.1002 0.0943
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0137 0.0471
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.1053 0.0956
Onchocerca volvulus 0.047 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Onchocerca volvulus 0.0063 0.1053 0.0956
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0522 0.0635
Brugia malayi Animal haem peroxidase family protein 0.0063 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0137 0.1561
Schistosoma mansoni cytochrome P450 0.0022 0.0137 0.0142
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0735 0.6291
Echinococcus multilocularis 0.0022 0.0137 0.0142
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0757 0.0937
Echinococcus granulosus protein jagged 2 0.0021 0.0107 0.0113
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0107 0.0103
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.1053 0.0993
Brugia malayi Delta serrate ligand family protein 0.0021 0.0107 0.0107
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0757 0.1026
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0207 0.2573
Brugia malayi nuclear receptor RXR 0.0056 0.0889 0.0889
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0757 0.0657
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0106 0.199 0.252
Leishmania major hypothetical protein, conserved 0.0025 0.0207 0.1602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Echinococcus multilocularis neural cadherin 0.0021 0.0107 0.0103
Brugia malayi cytochrome P450 0.0022 0.0137 0.0137
Loa Loa (eye worm) glutathione reductase 0.0049 0.0727 0.0666
Schistosoma mansoni cell polarity protein 0.0021 0.0107 0.0103
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0107 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0106 0.199 0.252
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0106 0.199 0.2761
Echinococcus granulosus protein kinase C gamma type 0.0058 0.0934 0.1276
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0757 0.0657
Echinococcus multilocularis lamin 0.0029 0.0285 0.0332
Schistosoma mansoni thyroid hormone receptor 0.0371 0.782 1
Brugia malayi hypothetical protein 0.0038 0.0496 0.0496
Loa Loa (eye worm) runx1 0.0059 0.0953 0.0893
Toxoplasma gondii thioredoxin reductase 0.0049 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0787 0.0726
Brugia malayi nuclear hormone receptor 0.005 0.0757 0.0757
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2774 0.3525
Echinococcus granulosus serine:threonine protein kinase N2 0.0019 0.0066 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1224 0.1537
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0285 0.0221
Brugia malayi Protein kinase domain containing protein 0.0019 0.0066 0.0066
Brugia malayi tailless protein 0.005 0.0757 0.0757
Onchocerca volvulus 0.01 0.1856 0.1768
Schistosoma mansoni notch 0.0021 0.0107 0.0103
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0735 0.6291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.199 0.199
Echinococcus multilocularis slit 2 protein 0.0021 0.0107 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2774 0.3525
Echinococcus granulosus protein jagged 2 0.0021 0.0107 0.0113
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0106 0.199 0.199
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0137 0.1561
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Onchocerca volvulus 0.005 0.0757 0.0657
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0137 0.0471
Echinococcus granulosus notch 0.0021 0.0107 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0106 0.199 0.199
Schistosoma mansoni thyroid hormone receptor 0.0371 0.782 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0174 0.3476 0.4851
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Loa Loa (eye worm) hypothetical protein 0.0025 0.0207 0.0142
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1152 0.1582
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0889 0.0889
Echinococcus granulosus ecdysone induced protein 78C 0.0106 0.199 0.2761
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0757 0.1026
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.21 0.8837
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Brugia malayi hypothetical protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0274 0.0209
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0496 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Echinococcus multilocularis protein kinase c epsilon type 0.0033 0.0383 0.0457
Loa Loa (eye worm) hypothetical protein 0.005 0.0757 0.0695
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0137 0.1561
Echinococcus granulosus NDR protein kinase 0.0019 0.0066 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0137 0.0471
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0207 0.2573
Echinococcus multilocularis thyroid hormone receptor alpha 0.0371 0.782 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0889 0.0889
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.2373 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0533 0.047
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0106 0.199 0.2761
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.21 0.8837
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0137 0.1561
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0757 0.0937
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1152 0.1443
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.1053 0.0993
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0496 0.0659
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.199 0.2761
Leishmania major cytochrome p450-like protein 0.0049 0.0735 0.6291
Brugia malayi Cadherin domain containing protein 0.0021 0.0107 0.0107
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0106 0.199 0.252
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.21 0.8837
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0137 0.0471
Loa Loa (eye worm) hypothetical protein 0.0169 0.3372 0.3328
Entamoeba histolytica hypothetical protein 0.0038 0.0496 0.3958
Brugia malayi nuclear receptor NHR-88 0.005 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0152 0.3011 0.2965
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0757 0.0757
Schistosoma mansoni lamin 0.0029 0.0285 0.0332
Giardia lamblia High cysteine protein 0.0021 0.0107 0.1697
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1856 0.2348
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0071 0.1224 0.1537
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1152 0.1093
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Echinococcus granulosus tumor protein p63 0.034 0.7139 1
Echinococcus multilocularis protein jagged 1 0.0021 0.0107 0.0103
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0137 0.0471
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.5485 0.7675
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1135 0.1422
Brugia malayi hypothetical protein 0.005 0.0757 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0106 0.199 0.1937
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0066 0.0829
Schistosoma mansoni ap endonuclease 0.0038 0.0498 0.0605
Echinococcus granulosus tar DNA binding protein 0.0067 0.1135 0.1558
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.0757 0.0937
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Brugia malayi EGF-like domain containing protein 0.0021 0.0107 0.0107
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1152 0.1443
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1135 0.1422
Brugia malayi intermediate filament protein 0.0029 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.005 0.0751 0.0689
Brugia malayi Cytochrome P450 family protein 0.0049 0.0735 0.0735
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0498 0.3981
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1152 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0757 0.0757
Schistosoma mansoni coup transcription factor 0.0106 0.199 0.252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0041
Loa Loa (eye worm) hypothetical protein 0.0134 0.2601 0.2552
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0137 0.0982
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0106 0.199 0.1937
Brugia malayi hypothetical protein 0.0056 0.0889 0.0889
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0137 0.1561
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.199 0.252
Schistosoma mansoni zinc finger protein 0.005 0.0757 0.0937
Brugia malayi Nuclear hormone receptor E75 0.005 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0029 0.0285 0.0221
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0106 0.199 0.1937

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 94 In vivo oral activity by air pouch assay on Sprague-Dawley rats at dose 2 mg/kg administered intragastrically in a volume of 5 mL/kg 2 hr prior to injection. ChEMBL. 8627608
ED50 (functional) = 0.05 mg kg-1 In vivo activity against rat adjuant-induced arthritis assay ChEMBL. 8627608
ED50 (functional) = 38.7 mg kg-1 In vivo activity against carrageena-induced hyperalgesia assay in rats at a dose of 200 mg/kg ChEMBL. 8627608
IC50 (binding) = 8.7 Inhibition of human Prostaglandin G/H synthase 2 ChEMBL. 11563921
IC50 (binding) = 0.002 uM In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 ChEMBL. 8627608
IC50 (binding) = 0.002 uM In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 ChEMBL. 8627608
IC50 (binding) = 5.5 uM In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 1. ChEMBL. 8627608
IC50 (binding) = 5.5 uM In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 1. ChEMBL. 8627608
Log IC50 (binding) = 8.7 Inhibition of human Prostaglandin G/H synthase 2 ChEMBL. 11563921
Selectivity (binding) = 2750 Ratio of inhibitory concentration of COX-1 and COX-2 measured for their oral activity in an acute inflammation model ChEMBL. 8627608
Selectivity (binding) = 2750 Ratio of inhibitory concentration of COX-1 and COX-2 measured for their oral activity in an acute inflammation model ChEMBL. 8627608

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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