Detailed information for compound 80241

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 602.572 | Formula: C30H33Cl2N3O4S
  • H donors: 1 H acceptors: 3 LogP: 4.62 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C)C(NCc1ccc(c(c1)Cl)Cl)COCc1ccccc1
  • InChi: 1S/C30H33Cl2N3O4S/c1-40(37,38)35-21-30(24-9-5-6-10-28(24)35)13-15-34(16-14-30)29(36)27(20-39-19-22-7-3-2-4-8-22)33-18-23-11-12-25(31)26(32)17-23/h2-12,17,27,33H,13-16,18-21H2,1H3
  • InChiKey: PEIMIJSROKINQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0246 0.0536
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0067 0.0127
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Brugia malayi CXXC zinc finger family protein 0.0031 0.022 0.0416
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0017 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0295 0.0295
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0286 0.0567
Loa Loa (eye worm) hypothetical protein 0.0056 0.0512 0.0984
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0073 0.0073
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0165 0.1254
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0073 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Schistosoma mansoni lamin 0.0056 0.0512 0.1022
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0803 1
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0286 0.0543
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0186
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.053 0.4097
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.053 0.1018
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0073 0.0073
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.053 0.4097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Onchocerca volvulus 0.0036 0.0281 0.0467
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0511
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0551 0.0551
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0051 0.0369
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.3698 0.5993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0055 0.0087
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0817 0.137
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0457 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Toxoplasma gondii hypothetical protein 0.0014 0.0027 0.0112
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0109 0.0284
Brugia malayi jmjC domain containing protein 0.0068 0.0653 0.125
Schistosoma mansoni synaptojanin 0.0016 0.0051 0.0095
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0061 0.0097
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0061 0.0116
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0313
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0061 0.0092
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0073 0.0139
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0109 0.0177
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0017 0.0171
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0803 0.3744
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Onchocerca volvulus 0.0016 0.0051 0.008
Onchocerca volvulus 0.0021 0.0107 0.0175
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0073 0.011
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0246 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0209
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0109 0.0164
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0128
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0061 0.0111
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0073 0.011
Echinococcus multilocularis pikachurin 0.0024 0.0141 0.0141
Onchocerca volvulus 0.0014 0.0027 0.0039
Brugia malayi nuclear receptor NHR-88 0.0036 0.0286 0.0543
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0067 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0107 0.1298
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.2059 0.2059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0061 0.0061
Echinococcus granulosus bloom syndrome protein 0.0021 0.0109 0.0164
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0151
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1288 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0202
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.3037
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0269 0.1289
Brugia malayi CHD4 protein 0.0015 0.0038 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0286 0.0549
Echinococcus multilocularis expressed protein 0.0036 0.0278 0.0278
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0633 0.0954
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0051 0.0369
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0803 0.2062
Schistosoma mansoni hypothetical protein 0.0265 0.2953 0.5932
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0803 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0286 0.0549
Brugia malayi hypothetical protein 0.0021 0.0107 0.0199
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0073 0.011
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0051 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0651 0.1301
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.01 0.01
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.2059 0.3102
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0265 0.2943 0.2943
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Trichomonas vaginalis chromobox protein, putative 0.005 0.0437 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Schistosoma mansoni cpg binding protein 0.0031 0.022 0.0435
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0286 0.0567
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Brugia malayi hypothetical protein 0.0021 0.01 0.0186
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0017 0.0028
Onchocerca volvulus 0.0056 0.0512 0.0856
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.01 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0278 0.0529
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Schistosoma mansoni polycystin 1-related 0.0021 0.0107 0.0209
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0186
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.01 0.0193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Leishmania major hypothetical protein, conserved 0.0022 0.0117 0.0553
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0061 0.0097
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0269 0.2063
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0157
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0038 0.0038
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Brugia malayi 6-phosphofructokinase 0.0123 0.1288 0.247
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.01
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0634 0.1218
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0195
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0061 0.0092
Onchocerca volvulus 0.0014 0.0027 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0286 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0286 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Echinococcus multilocularis aminopeptidase N 0.0012 0.0004 0.0004
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0051 0.0369
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0286 0.0567
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.053 0.1313
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0099 0.016
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0051 0.008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Brugia malayi nuclear receptor NHR-67 0.0017 0.0061 0.0111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.1288 1
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0614 0.2969
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Brugia malayi conserved hypotetical protein 0.0017 0.0061 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0286 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0286 0.0549
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0017 0.0028
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0073 0.0139
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0023
Onchocerca volvulus 0.0036 0.0286 0.0475
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi tailless protein 0.0017 0.0061 0.0111
Schistosoma mansoni lipoxygenase 0.0021 0.0107 0.0209
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0206
Schistosoma mansoni rab6-interacting 0.0021 0.0107 0.0209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.2059 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0246 0.1181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0017 0.0026
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0614 0.0925
Echinococcus granulosus aminopeptidase N 0.0012 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0286 0.0543
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0051 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0569 0.2752
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1735 0.8425
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.01 0.0195
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0017 0.0028
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0551 0.083
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0073 0.0133
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trichomonas vaginalis hypothetical protein 0.0013 0.0017 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0017 0.0026
Loa Loa (eye worm) DR-78 0.0017 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0281 0.054
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.3037
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0117 0.1421
Echinococcus granulosus slit 2 protein 0.0024 0.0141 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0109 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0073 0.014
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0106 0.016
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0165 0.1254
Echinococcus granulosus pikachurin 0.0024 0.0141 0.0212
Brugia malayi jmjC domain containing protein 0.0066 0.0633 0.121
Leishmania major hypothetical protein, conserved 0.0018 0.0067 0.0307
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.4975 0.4975
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0061 0.0118
Echinococcus granulosus voltage dependent calcium channel subunit 0.0265 0.2943 0.4434
Leishmania major hypothetical protein, conserved 0.0026 0.0165 0.0784
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0051 0.0051
Schistosoma mansoni cpg binding protein 0.0033 0.024 0.0476
Onchocerca volvulus 0.0018 0.0073 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Echinococcus granulosus lamin dm0 0.0056 0.0512 0.0771
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0051 0.0077
Schistosoma mansoni lipoxygenase 0.0059 0.0551 0.1101
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0165 0.0784
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0286 0.043
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Loa Loa (eye worm) RecQ helicase 0.0021 0.0109 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0085 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Schistosoma mansoni hypothetical protein 0.0037 0.0295 0.0585
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0803 0.6223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi hypothetical protein 0.0037 0.0295 0.056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.01 0.0186
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0286 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0341 0.3827 0.7356
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0073 0.0133
Brugia malayi hypothetical protein 0.0131 0.1383 0.2652
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0038 0.0069
Echinococcus granulosus nAChR subunit 0.0018 0.0073 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0286 0.0549
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0051 0.0128
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0539 0.6136 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0397 0.0662
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3378 0.6787
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0286 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.024 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0286 0.0543
Brugia malayi steroid hormone receptor 0.0036 0.0286 0.0543
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.2953 0.4449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0109 0.0109
Brugia malayi Heterochromatin protein 1 0.0082 0.0817 0.1564
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0286 0.0286
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0141 0.0276
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0051 0.0593
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0246 0.1181
Brugia malayi hypothetical protein 0.0021 0.0107 0.0199
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Schistosoma mansoni hypothetical protein 0.0016 0.0051 0.0095
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0067 0.0307
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0073 0.0133
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0106 0.0205
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Echinococcus multilocularis chromobox protein 1 0.0082 0.0817 0.0817
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0073 0.014
Schistosoma mansoni rab6-interacting 0.0021 0.0107 0.0209
Onchocerca volvulus 0.0016 0.0051 0.008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0109 0.0109
Schistosoma mansoni DNA helicase recq1 0.0021 0.0109 0.0211
Schistosoma mansoni axis inhibition protein axin 0.0021 0.01 0.0195
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0175 0.0264
Echinococcus granulosus chromobox protein 1 0.0082 0.0817 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0397 0.0662
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Echinococcus granulosus expressed protein 0.0401 0.4528 0.6822
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.021 0.0396
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0151
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1288 0.2475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0051 0.0369
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2969
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0109 0.1314
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0051 0.0051
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.053 0.256
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0286 0.0475
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0061 0.0097
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0286 0.043
Schistosoma mansoni chromobox protein 0.0082 0.0817 0.1636
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.01
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0051 0.0077
Brugia malayi Pre-SET motif family protein 0.0459 0.5203 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0061 0.0111
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0141 0.0212
Onchocerca volvulus 0.0018 0.0073 0.0117
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0246 0.0321
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0073 0.011
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0061 0.0116
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0061 0.0116
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Onchocerca volvulus 0.0056 0.0512 0.0856
Loa Loa (eye worm) hypothetical protein 0.0046 0.0397 0.0762
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Brugia malayi CCR4 0.0016 0.0051 0.0091
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0286 0.043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0067 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0061 0.0061
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0818
Schistosoma mansoni zinc finger protein 0.0017 0.0061 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.053 0.4097
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0039 0.0072
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0128 0.1351 0.271
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Onchocerca volvulus 0.0018 0.0073 0.0117
Brugia malayi Pre-SET motif family protein 0.0066 0.0634 0.1212
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0061 0.0092
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0803 0.1236
Schistosoma mansoni cpg binding protein 0.0033 0.024 0.0476
Schistosoma mansoni synaptojanin 0.0016 0.0051 0.0095
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0027 0.0112
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0151
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0633 0.0633
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0051 0.023
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0117 0.0225
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1735 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.2059 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0512 0.0984
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0803 0.1543
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0061 0.0061
Echinococcus granulosus Chromobox protein 3 0.0013 0.0017 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0286 0.0543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0073 0.0133
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0286 0.0567
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0336
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0817 0.157
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.01 0.0186
Schistosoma mansoni slit 0.0024 0.0141 0.0276
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0051 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Trypanosoma brucei protein kinase, putative 0.0057 0.053 0.4097
Echinococcus multilocularis lamin 0.0056 0.0512 0.0512
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.01 0.01
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.01 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2804
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0286 0.0543
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0017 0.0017
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0051 0.0098
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0073 0.0133
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.01 0.01
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0051 0.0369
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0017 0.0171
Echinococcus multilocularis chromobox protein 2 0.0013 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.01 0.0151
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0051 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.053 0.1058
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0017 0.0067
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0038 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0117 0.0553
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0117 0.1421
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.01 0.01
Echinococcus granulosus intermediate filament protein 0.0056 0.0512 0.0771
Echinococcus multilocularis musashi 0.0056 0.0512 0.0512
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0027 0.0051
Echinococcus granulosus cpg binding protein 0.0033 0.024 0.0362
Echinococcus multilocularis RUN 0.0021 0.0107 0.0107
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.01 0.0193
Brugia malayi hypothetical protein 0.0017 0.0061 0.0111
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.053 0.0798
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0803 0.3889
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.01 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Trichomonas vaginalis chromobox protein, putative 0.005 0.0437 0.0731
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0073 0.014
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0051 0.0593
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0051 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Trichomonas vaginalis rotamase, putative 0.0036 0.0278 0.0463
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0286 0.0286
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0634 0.3066
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0051 0.0593
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0107 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Brugia malayi chromobox protein homolog 3 0.0046 0.0397 0.0756
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0803 0.1537
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0633 0.1266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0085 0.0157
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0073 0.011
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0051 0.0077
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0206
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0073 0.0073
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0286 0.0286
Brugia malayi MAP kinase sur-1 0.0057 0.053 0.1012
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0017 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0633 0.0633
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0067 0.0307
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.01 0.0151
Onchocerca volvulus 0.0014 0.0027 0.0039
Brugia malayi intermediate filament protein 0.0056 0.0512 0.0978
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0653 0.1256
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0269 0.0717
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0634 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0051 0.0369
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0067 0.01
Brugia malayi hypothetical protein 0.0106 0.1097 0.2102
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0165 0.2016
Brugia malayi hypothetical protein 0.0021 0.01 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0061 0.0092
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0073 0.011
Echinococcus multilocularis cpg binding protein 0.0033 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Loa Loa (eye worm) hypothetical protein 0.0051 0.0457 0.0878
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Schistosoma mansoni rotamase 0.0036 0.0278 0.0553
Toxoplasma gondii subtilisin SUB12 0.0014 0.0027 0.0112
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0803 0.0803
Brugia malayi Cation transporter family protein 0.0018 0.0073 0.0133
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0085 0.0164
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0107 0.1298
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0141 0.0141
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0067 0.01
Plasmodium vivax SET domain protein, putative 0.0066 0.0634 0.7885
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0023
Echinococcus granulosus geminin 0.0382 0.4305 0.6486
Brugia malayi nuclear receptor RXR 0.0019 0.0085 0.0157
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0067 0.0128
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0017 0.0067
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0051 0.023
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0087 0.0131
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0195
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0061 0.0097
Onchocerca volvulus 0.0522 0.594 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.01 0.0151
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.1288 0.616
Onchocerca volvulus 0.0014 0.0027 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0286 0.0475
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0225
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.01 0.01
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0051 0.0128
Loa Loa (eye worm) RGS-3 protein 0.0021 0.01 0.0193
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0286 0.0567
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0017 0.0026
Onchocerca volvulus 0.0018 0.0073 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Onchocerca volvulus 0.0021 0.0107 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0085 0.0164
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0141 0.027
Schistosoma mansoni nuclear receptor 0.0017 0.0061 0.0116
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0107 0.0107
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.3037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0085 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Onchocerca volvulus 0.0014 0.0027 0.0039
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0614 0.1228
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1735 0.8388
Loa Loa (eye worm) phosphofructokinase 0.0123 0.1288 0.2475
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.053 0.256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0106 0.0198
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0073 0.0073
Onchocerca volvulus 0.0013 0.0017 0.0023
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0614 0.1174
Loa Loa (eye worm) hypothetical protein 0.0117 0.1225 0.2354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.053 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0286 0.0567
Echinococcus granulosus synaptojanin 1 0.0016 0.0051 0.0077
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Onchocerca volvulus 0.008 0.079 0.1325
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0246 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.008 0.079 0.1582
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Onchocerca volvulus 0.0051 0.0457 0.0764
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.1288 0.6248
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.2549 0.512
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0038 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.1288 0.194
Loa Loa (eye worm) helicase 0.0013 0.0017 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1288 0.2583
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0246 0.0409
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0027 0.0112
Schistosoma mansoni cell polarity protein 0.0024 0.0141 0.0276
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.1288 0.2583
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0051 0.0593
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0313
Echinococcus multilocularis expressed protein 0.0401 0.4528 0.4528
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0073 0.011
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0803 0.1346
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0073 0.014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.1288 0.2033
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.053 0.0886
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0246 0.1181
Schistosoma mansoni ap endonuclease 0.0081 0.0803 0.1608
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0246 0.5
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0051 0.0077
Onchocerca volvulus 0.0017 0.0061 0.0097
Schistosoma mansoni nocturnin 0.0016 0.0051 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0634 0.0634
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0073 0.014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0286 0.0543
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0286 0.0543
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0023
Entamoeba histolytica hypothetical protein 0.0013 0.0017 0.0037
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.053 0.4097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0512 0.0984
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0051 0.0077
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0512 0.0978
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0269 0.2063
Onchocerca volvulus 0.0014 0.0027 0.0039
Onchocerca volvulus Putative nachr subunit 0.0018 0.0073 0.0117
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0073 0.0139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0598 0.0901
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0067 0.01
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0109 0.0209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0099 0.016
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0061 0.0118
Onchocerca volvulus 0.0014 0.0027 0.0039
Brugia malayi 6-phosphofructokinase 0.0123 0.1288 0.247
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3698 1
Brugia malayi Protein cec-1. 0.0013 0.0017 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0286 0.0543
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0067 0.0127
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0278 0.0535
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0295 0.0444
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0087 0.0087
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0073 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0382 0.4305 0.8652
Onchocerca volvulus 0.0017 0.0061 0.0097
Schistosoma mansoni nuclear receptor 0.0017 0.0061 0.0116
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0051 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.01 0.0195
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0817 0.137
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.053 0.4097
Brugia malayi Protein kinase domain containing protein 0.0022 0.0117 0.0218
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.021 0.0403
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0107 0.0162
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0437 0.0731
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0286 0.0286
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0051 0.0098
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Plasmodium vivax JmjC domain containing protein 0.0018 0.0067 0.0789
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Echinococcus multilocularis Chromo domain 0.0013 0.0017 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.2059 0.4134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0051 0.0593
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0051 0.0051
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0117 0.0117
Schistosoma mansoni serine-rich repeat protein 0.0137 0.1453 0.2914
Brugia malayi laminin alpha chain 0.0024 0.0141 0.0264
Onchocerca volvulus 0.0031 0.022 0.0364
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0803 0.3889
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0109 0.0177
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0073 0.0073
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0067 0.0127
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0107 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0302 0.3378 0.3378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0061 0.0092
Schistosoma mansoni DNA helicase recq5 0.0021 0.0109 0.0211
Echinococcus multilocularis synaptojanin 1 0.0016 0.0051 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0017 0.0023
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0027 0.0112
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0107 0.0107
Brugia malayi nuclear hormone receptor 0.0017 0.0061 0.0111
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0051 0.023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.5203 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0067 0.0789
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0207
Trichomonas vaginalis set domain proteins, putative 0.0522 0.594 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0286 0.0543
Toxoplasma gondii hypothetical protein 0.0014 0.0027 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0021 0.01 0.0195
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0061 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0109 0.0177
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0073 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.024 0.0399
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0073 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus granulosus Chromo domain 0.0013 0.0017 0.0026
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0141 0.027
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.014
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0165 0.1254
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.1288 0.2163
Schistosoma mansoni loxhd1 0.0021 0.0107 0.0209
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0004 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0286 0.0549
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0803 0.6223
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0118
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.3698 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.053 0.256
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0117 0.0884
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0141 0.0264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0099 0.016
Schistosoma mansoni hypothetical protein 0.0137 0.1453 0.2914
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0269 0.1289
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0803 0.1346
Schistosoma mansoni coup transcription factor 0.0036 0.0286 0.0567
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0286 0.0549
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Brugia malayi SET domain containing protein 0.0017 0.0053 0.0096
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0141 0.0276
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0165 0.0316
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0073 0.0073
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0017 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0051 0.0369
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Onchocerca volvulus 0.0013 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0022 0.0117 0.0228
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Toxoplasma gondii microneme protein, putative 0.0014 0.0027 0.0112
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0286 0.0475
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0051 0.008
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0037
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0027 0.0112
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0067 0.0491
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0397 0.0662
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0061 0.0092
Schistosoma mansoni chromobox protein 0.0013 0.0017 0.0028
Echinococcus multilocularis nAChR subunit 0.0018 0.0073 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Onchocerca volvulus 0.0014 0.0027 0.0039
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.0073
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0164
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.1288 0.2475
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0107 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0051 0.0369
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0017 0.0171
Brugia malayi hypothetical protein 0.0013 0.0017 0.0026
Brugia malayi hypothetical protein 0.0019 0.0085 0.0157
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0051 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0128
Brugia malayi Kringle domain containing protein 0.0022 0.0117 0.0218
Brugia malayi nuclear receptor NHR-88 0.0017 0.0061 0.0111
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0017 0.0171
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0067 0.0127
Entamoeba histolytica hypothetical protein 0.0021 0.01 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3378 0.6787
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0073 0.0133
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.2549 0.4899
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.022 0.0423
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.01 0.0151
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0286 0.0567
Schistosoma mansoni nAChR subunit 0.0018 0.0073 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.01 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0653 0.1307
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0051 0.0593
Schistosoma mansoni chromobox protein 0.0082 0.0817 0.1636
Echinococcus granulosus chromobox protein 1 0.0082 0.0817 0.1231
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0803 0.5
Echinococcus granulosus lamin 0.0056 0.0512 0.0771
Echinococcus multilocularis slit 2 protein 0.0024 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0278 0.0463
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0286 0.043
Echinococcus multilocularis geminin 0.0382 0.4305 0.4305
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.01 0.01
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0061 0.0116
Onchocerca volvulus 0.0018 0.0073 0.0117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0269 0.2063
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0109 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0061 0.0061
Brugia malayi hypothetical protein 0.0017 0.0061 0.0111
Schistosoma mansoni cript-related 0.0016 0.0051 0.0095
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0073 0.011
Brugia malayi Cytochrome P450 family protein 0.0023 0.0124 0.0232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.2059 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0582 0.6637 0.6637
Brugia malayi phosphofructokinase 0.0123 0.1288 0.247
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0073 0.0139
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0107 0.0107
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0109 0.0202
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0286 0.043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0286 0.0286
Brugia malayi hypothetical protein 0.0026 0.0165 0.031
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0124 0.0238
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0286 0.0543
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.3037
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0051 0.0051
Brugia malayi jmjC domain containing protein 0.0018 0.0067 0.0121
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0004 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0803 0.121
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0653 0.0984
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0017 0.0171
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.2059 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0286 0.0549
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0593
Brugia malayi hypothetical protein 0.0019 0.0085 0.0157
Schistosoma mansoni hypothetical protein 0.0382 0.4305 0.8652
Brugia malayi PXA domain containing protein 0.0021 0.01 0.0186
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0286 0.0543
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0818
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0051 0.0051
Echinococcus granulosus tumor protein p63 0.035 0.3935 0.5929
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0803 0.6223
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0563 0.1082
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0051 0.008
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.1288 0.1288
Brugia malayi ecdysone receptor 0.0017 0.0061 0.0111
Entamoeba histolytica hypothetical protein 0.0037 0.0295 0.0788
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0051 0.0593
Brugia malayi nuclear hormone receptor 0.0036 0.0286 0.0543
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.2549 0.3841
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0051 0.0369
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.1288 0.6248
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0803 0.2163
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0017 0.0026
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0073 0.014
Schistosoma mansoni intermediate filament proteins 0.0056 0.0512 0.1022
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.053 0.053
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0286 0.0567
Brugia malayi EGF-like domain containing protein 0.0024 0.0141 0.0264
Echinococcus granulosus chromobox protein 2 0.0013 0.0017 0.0026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0109 0.0511
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.2953 0.2953
Toxoplasma gondii exonuclease III APE 0.0081 0.0803 0.3889
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0193
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0634 0.0634
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0175 0.0175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0653 0.1307
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0073 0.0133
Brugia malayi hypothetical protein 0.0017 0.0057 0.0103
Echinococcus granulosus expressed protein 0.0036 0.0278 0.0419
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0295 0.0585
Trichomonas vaginalis rotamase, putative 0.0035 0.0269 0.0446
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0254 0.2817 0.5659
Leishmania major hypothetical protein, conserved 0.0016 0.0051 0.023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0286 0.0549
Brugia malayi Doublecortin family protein 0.0021 0.0107 0.0199
Schistosoma mansoni lamin 0.0056 0.0512 0.1022
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0073 0.0073
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.053 0.053
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0109 0.0511
Toxoplasma gondii microneme protein MIC4 0.0014 0.0027 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0073 0.011
Echinococcus multilocularis chromobox protein 1 0.0082 0.0817 0.0817
Brugia malayi Cache domain containing protein 0.0117 0.1225 0.2349
Echinococcus multilocularis tumor protein p63 0.035 0.3935 0.3935
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0027 0.0112
Echinococcus granulosus dnaJ subfamily B 0.0439 0.4975 0.7496
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0614 0.2969
Onchocerca volvulus 0.0022 0.0117 0.0191
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0286 0.0567
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0117 0.0176
Schistosoma mansoni chromobox protein 0.0013 0.0017 0.0028
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0286 0.0543
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0286 0.043
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0051 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0017 0.0171
Schistosoma mansoni ap endonuclease 0.0081 0.0803 0.1608
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3698 1
Echinococcus granulosus RUN 0.0021 0.0107 0.0162
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.2059 0.4134
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0141 0.0264
Brugia malayi PAN domain containing protein 0.0014 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.014
Echinococcus granulosus phd:f box containing protein 0.0018 0.0067 0.01
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0106 0.0205
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0051 0.0369
Echinococcus granulosus voltage dependent calcium channel subunit 0.0582 0.6637 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0021 0.0107 0.0209
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.1288 0.3476
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0051 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.01 0.0163
Brugia malayi nuclear receptor RXR 0.0017 0.0061 0.0111
Echinococcus multilocularis lamin dm0 0.0056 0.0512 0.0512
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0073 0.011
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0067 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3698 0.6223
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0051 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.0409
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0085 0.0164
Schistosoma mansoni hypothetical protein 0.0439 0.4975 1
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0051 0.0593
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0051 0.0369
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0286 0.043
Onchocerca volvulus 0.0018 0.0073 0.0117
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0051 0.0128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0549
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0286 0.0567
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0109 0.1314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.05 0.0961
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0051 0.0095
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0027 0.0112
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.01 0.0186
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0061 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0634 0.1268
Brugia malayi ecdysteroid receptor 0.0036 0.0286 0.0543
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0067 0.0067

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12 nM Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells ChEMBL. 9873445
IC50 (binding) = 12 nM Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells ChEMBL. 9873445

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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