Detailed information for compound 81446

Basic information

Technical information
  • TDR Targets ID: 81446
  • Name: 3-[(5-chlorothiophen-2-yl)methyl]-1H-imidazol e-2-thione
  • MW: 230.738 | Formula: C8H7ClN2S2
  • H donors: 0 H acceptors: 1 LogP: 2.77 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(s1)Cn1ccnc1S
  • InChi: 1S/C8H7ClN2S2/c9-7-2-1-6(13-7)5-11-4-3-10-8(11)12/h1-4H,5H2,(H,10,12)
  • InChiKey: HUBGMTPUQDQWMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(5-chloro-2-thienyl)methyl]-1H-imidazole-2-thione
  • 1-[(5-chloro-2-thienyl)methyl]-4-imidazoline-2-thione
  • 1-[(5-chlorothiophen-2-yl)methyl]-3H-imidazole-2-thione
  • 1-[(5-chloro-2-thienyl)methyl]-3H-imidazole-2-thione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Dopamine beta-hydroxylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni dopamine-beta-monooxygenase Get druggable targets OG5_129281 All targets in OG5_129281
Schistosoma japonicum ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative Get druggable targets OG5_129281 All targets in OG5_129281
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0583 0.2155 0.4976
Onchocerca volvulus 0.002 0.0021 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0046 0.0818
Brugia malayi Protein kinase domain containing protein 0.0025 0.0037 0.0103
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Brugia malayi nuclear receptor NHR-88 0.0018 0.001 0.0018
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Leishmania major hypothetical protein, conserved 0.0027 0.0046 0.0321
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0084 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0015 0.0035
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0197 0.5026
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0018 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0095 0.0085
Echinococcus granulosus nAChR subunit 0.0019 0.0015 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Schistosoma mansoni dopamine-beta-monooxygenase 0.0283 0.1016 0.2347
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0415 0.4461
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Brugia malayi hypothetical protein 0.002 0.0018 0.0043
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0071 0.1516
Onchocerca volvulus 0.0018 0.001 0.0016
Loa Loa (eye worm) DOMON domain-containing protein 0.0029 0.0052 0.0149
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0015 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0084 0.0075
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Loa Loa (eye worm) leukotriene A4 hydrolase 0.024 0.0856 0.2651
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0266 0.0953 0.2201
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2521
Schistosoma mansoni hypothetical protein 0.0049 0.013 0.03
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0135 0.0408
Brugia malayi nuclear hormone receptor 0.0037 0.0084 0.025
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0375 0.1155
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0084 0.0075
Echinococcus granulosus cpg binding protein 0.0031 0.0062 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0127 0.0384
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0015 0.0005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0197 0.5026
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0055 0.0045
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.009 0.0209
Schistosoma mansoni DNA helicase recq1 0.0029 0.0055 0.0127
Echinococcus granulosus voltage dependent calcium channel subunit 0.1205 0.4517 0.4512
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0049 0.013 0.5111
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Onchocerca volvulus 0.0982 0.3669 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0011
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0074 0.0173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Echinococcus granulosus lamin 0.0086 0.0271 0.0262
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.009 0.204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0084 0.0075
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0149 0.051 0.1177
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.001 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0046 0.0818
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.093 0.0921
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0071 0.1899
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0049 0.013 0.0393
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1094 0.2527
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Onchocerca volvulus 0.0019 0.0015 0.0031
Echinococcus granulosus tumor protein p63 0.0364 0.1326 0.1318
Schistosoma mansoni lamin 0.0086 0.0271 0.0626
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Echinococcus multilocularis cpg binding protein 0.0031 0.0062 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0958
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0095 0.0283
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0375 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0084 0.0075
Schistosoma mansoni peptidylglycine monooxygenase 0.0149 0.051 0.1177
Brugia malayi hypothetical protein 0.0027 0.0046 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0084 0.025
Onchocerca volvulus 0.0019 0.0015 0.0031
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0043
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0071 0.1516
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.009 0.008
Brugia malayi Cation transporter family protein 0.0019 0.0015 0.0035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0084 0.025
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0095 0.0085
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0375 0.0866
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0071 0.0594
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1156 0.433 1
Brugia malayi hypothetical protein 0.0018 0.0011 0.0022
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0055 0.0045
Onchocerca volvulus 0.0025 0.0037 0.009
Echinococcus multilocularis pikachurin 0.0048 0.0127 0.0118
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0084 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Toxoplasma gondii microneme protein MIC17C 0.0016 0.0004 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0065 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0084 0.025
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0025 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.066 0.245 0.7613
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0015 0.0035
Brugia malayi Cytochrome P450 family protein 0.0073 0.0219 0.067
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0033 0.0091
Brugia malayi Sulfatase family protein 0.0018 0.0011 0.0022
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0021 0.009
Brugia malayi ecdysone receptor 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0149 0.051 0.1575
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0149 0.051 0.0501
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0197 0.0601
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0043
Entamoeba histolytica elongation factor-2 kinase, putative 0.0049 0.013 0.3462
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0084 0.025
Schistosoma mansoni coup transcription factor 0.0037 0.0084 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0037 0.0555
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Brugia malayi hypothetical protein 0.002 0.0021 0.0052
Onchocerca volvulus 0.0053 0.0145 0.0387
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0037 0.0899
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.0218
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0095 0.0085
Brugia malayi Pre-SET motif family protein 0.0124 0.0415 0.1279
Loa Loa (eye worm) hypothetical protein 0.0114 0.0374 0.1153
Echinococcus multilocularis tumor protein p63 0.0364 0.1326 0.1318
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.009 0.008
Echinococcus multilocularis expressed protein 0.0777 0.2893 0.2886
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Loa Loa (eye worm) hypothetical protein 0.0124 0.0415 0.1279
Brugia malayi hypothetical protein 0.0039 0.009 0.027
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0095 0.0283
Onchocerca volvulus 0.0086 0.0271 0.0729
Echinococcus granulosus bloom syndrome protein 0.0042 0.0103 0.0093
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0071 0.1516
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0015 0.0005
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0197 0.5251
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0375 0.0366
Toxoplasma gondii hypothetical protein 0.0016 0.0004 0.0039
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.0882 0.2733
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0375 1
Brugia malayi hypothetical protein 0.0049 0.013 0.0393
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0084 0.0075
Schistosoma mansoni axis inhibition protein axin 0.004 0.0095 0.0218
Echinococcus granulosus lamin dm0 0.0086 0.0271 0.0262
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0127 0.0384
Echinococcus multilocularis slit 2 protein 0.0048 0.0127 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0095 0.0085
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0049 0.013 0.2837
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.001 0.0022
Onchocerca volvulus 0.0049 0.013 0.0344
Loa Loa (eye worm) doublecortin family protein 0.002 0.0021 0.0052
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0145 0.0336
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0375 0.3961
Toxoplasma gondii microneme protein MIC17A 0.0016 0.0004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0105 0.0341 0.0788
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0015 0.0035
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0095 0.0283
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0015 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0021 0.0162
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0238 0.2469
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0015 0.0035
Brugia malayi PXA domain containing protein 0.004 0.0095 0.0283
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.001 0.0018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0095 0.0218
Brugia malayi intermediate filament protein 0.0086 0.0271 0.0832
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Loa Loa (eye worm) CUTiclin family member 0.0049 0.013 0.0393
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0021 0.0011
Echinococcus multilocularis lamin dm0 0.0086 0.0271 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0084 0.025
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0127 0.0384
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Loa Loa (eye worm) RecQ helicase 0.0042 0.0103 0.0309
Brugia malayi Nuclear hormone receptor E75 0.0018 0.001 0.0018
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0049 0.013 0.0393
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0149 0.051 0.0501
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0095 0.0283
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0197 0.0187
Plasmodium vivax SET domain protein, putative 0.0124 0.0415 1
Brugia malayi hypothetical protein 0.0253 0.0905 0.2805
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0015 0.0035
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0375 0.1155
Brugia malayi Pre-SET motif family protein 0.0862 0.3217 1
Loa Loa (eye worm) hypothetical protein 0.0533 0.1968 0.6112
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0375 0.0366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0375 0.0721
Schistosoma mansoni cpg binding protein 0.0031 0.0062 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0269
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.0236 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0084 0.025
Loa Loa (eye worm) glutamate receptor 0.0092 0.0293 0.0901
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.093 1
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0049 0.013 0.2837
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.0218
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0046 0.1326
Onchocerca volvulus 0.0049 0.013 0.0344
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0285
Loa Loa (eye worm) hypothetical protein 0.0048 0.0127 0.0384
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.093 0.0921
Schistosoma mansoni lipoxygenase 0.002 0.0021 0.0047
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0015 0.0035
Onchocerca volvulus 0.0086 0.0271 0.0729
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0015 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0018 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0084 0.0075
Brugia malayi follicle stimulating hormone receptor 0.0247 0.0882 0.2733
Toxoplasma gondii microneme protein MIC2 0.0049 0.013 0.1396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0084 0.0075
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0182
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0055 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0395 0.0386
Schistosoma mansoni loxhd1 0.002 0.0021 0.0047
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2649 1 1
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0084 0.0194
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0095 0.0283
Brugia malayi nuclear receptor NHR-88 0.0037 0.0084 0.025
Brugia malayi conserved hypotetical protein 0.0018 0.001 0.0018
Schistosoma mansoni slit 0.0048 0.0127 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0084 0.025
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0197 0.1971
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0055 0.0045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.1094 0.1086
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0015 0.0035
Echinococcus granulosus axis inhibition protein axin 0.004 0.0095 0.0085
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0271 0.0832
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0101 0.0092
Treponema pallidum 76K protein 0.0049 0.013 0.0249
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0139
Echinococcus granulosus slit 2 protein 0.0048 0.0127 0.0118
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0022
Brugia malayi Doublecortin family protein 0.002 0.0021 0.0052
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0017 0.0452
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0238 0.0728
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.006 0.1075
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0038 0.0535
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.0218
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.0953 0.0944
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0011
Brugia malayi nuclear hormone receptor 0.0018 0.001 0.0018
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0095 0.0085
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0049 0.013 0.012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0862 0.3217 1
Onchocerca volvulus 0.0049 0.013 0.0344
Onchocerca volvulus 0.0019 0.0015 0.0031
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0095 0.0085
Onchocerca volvulus 0.0049 0.013 0.0344
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0033 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0018 0.0043
Schistosoma mansoni nuclear receptor 0.0018 0.001 0.0022
Brugia malayi nuclear receptor RXR 0.0018 0.001 0.0018
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0037 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0053
Brugia malayi nuclear receptor RXR 0.002 0.0018 0.0043
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0021 0.0011
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.009 0.0208
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.009 0.0216
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0015 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0084 0.0194
Brugia malayi hypothetical protein 0.0018 0.001 0.0018
Loa Loa (eye worm) RGS-3 protein 0.004 0.0095 0.0283
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0095 0.0283
Brugia malayi ecdysteroid receptor 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Brugia malayi DOMON domain containing protein 0.0029 0.0052 0.0149
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0055 0.0589
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.009 0.008
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.0247 0.0883 0.2735
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.093 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0084 0.025
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0271 0.0832
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0375 0.3961
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0375 0.1155
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0084 0.026 0.0799
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0015 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0036 0.0388
Brugia malayi Cation transporter family protein 0.0019 0.0015 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0084 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0958
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0011 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0084 0.0219
Schistosoma mansoni DNA helicase recq5 0.0029 0.0055 0.0127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0084 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0415 0.0958
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0015 0.0005
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1386 0.5203 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.024 0.0856 0.0847
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0015 0.0035
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0084 0.0075
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0103 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0015 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0084 0.025
Schistosoma mansoni hypothetical protein 0.0622 0.2305 0.5324
Loa Loa (eye worm) hypothetical protein 0.0048 0.0127 0.0384
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.009 0.0081
Plasmodium vivax thrombospondin-related anonymous protein 0.0049 0.013 0.2837
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.006 0.1075
Leishmania major hypothetical protein, conserved 0.0025 0.0037 0.0217
Schistosoma mansoni serine-rich repeat protein 0.0622 0.2305 0.5324
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0304
Brugia malayi hypothetical protein 0.0247 0.0883 0.2735
Schistosoma mansoni intermediate filament proteins 0.0086 0.0271 0.0626
Brugia malayi Cache domain containing protein 0.0533 0.1968 0.6112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Brugia malayi hypothetical protein 0.0018 0.001 0.0019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0095 0.0218
Brugia malayi PXA domain containing protein 0.004 0.0095 0.0283
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0017 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0084 0.0075
Schistosoma mansoni hypothetical protein 0.0039 0.009 0.0209
Echinococcus multilocularis musashi 0.0086 0.0271 0.0262
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0375 1
Schistosoma mansoni hypothetical protein 0.002 0.0021 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0046 0.1326
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.016 0.0151
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0103 0.0093
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0375 0.0866
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Schistosoma mansoni polycystin 1-related 0.002 0.0021 0.0047
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0074 0.0222 0.068
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.0415 0.0406
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1094 0.2527
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0119 0.0358
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0095 0.0229
Schistosoma mansoni nuclear hormone receptor 0.0018 0.001 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0084 0.0194
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.006 0.0642
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0015 0.0005
Schistosoma mansoni hypothetical protein 0.0175 0.0609 0.1406
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0197 0.0187
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0095 0.0218
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0197 0.0455
Echinococcus granulosus RUN 0.002 0.0021 0.0011
Schistosoma mansoni cpg binding protein 0.0031 0.0062 0.0144
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0883 0.0874
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0095 0.0283
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0065 0.1336
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0197 0.5026
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0015 0.0035
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.001 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.0218
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0095 0.0085
Onchocerca volvulus 0.0049 0.013 0.0344
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0084 0.0219
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.0415 0.0406
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0039
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0074 0.022
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0037 0.0027
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.009 0.0081
Onchocerca volvulus 0.0037 0.0084 0.0219
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0041
Brugia malayi hypothetical protein 0.0018 0.001 0.0018
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0015 0.0035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.313 0.3123
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0238 0.555
Entamoeba histolytica hypothetical protein 0.0039 0.009 0.2409
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.009 0.204
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0071 0.0766
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Mycobacterium ulcerans epimerase 0.002 0.0021 0.0105
Brugia malayi nuclear receptor NHR-67 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0015 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0174 0.1872
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.006 0.1937
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0219 0.067
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0015 0.0035
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.006 0.1593
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.013 0.0393
Loa Loa (eye worm) hypothetical protein 0.0086 0.0271 0.0832
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0015 0.0035
Entamoeba histolytica hypothetical protein 0.0049 0.013 0.3462
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0033 0.0091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0015 0.0035
Onchocerca volvulus Putative nachr subunit 0.0019 0.0015 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.155 0.1542
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0101 0.0092
Brugia malayi Nuclear hormone receptor E75 0.0018 0.001 0.0018
Onchocerca volvulus 0.0019 0.0015 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0095 0.0283
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0018 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.093 0.2147
Entamoeba histolytica hypothetical protein 0.0039 0.009 0.2409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0084 0.025
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0095 0.0085
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.009 0.24
Toxoplasma gondii microneme protein, putative 0.0016 0.0004 0.0039
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.016 0.0151
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0049 0.013 0.2837
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0084 0.025
Echinococcus multilocularis lamin 0.0086 0.0271 0.0262
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2521
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0049 0.013 0.0325
Echinococcus multilocularis RUN 0.002 0.0021 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.009 0.0208
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0017 0.0066
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.009 0.008
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0015 0.0005
Brugia malayi Zona pellucida-like domain containing protein 0.0049 0.013 0.0393
Schistosoma mansoni hypothetical protein 0.005 0.0135 0.0311
Schistosoma mansoni nuclear receptor 0.0018 0.001 0.0022
Onchocerca volvulus 0.005 0.0135 0.0357
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0005 0.0011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0055 0.0159
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.001 0.0018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.093 1
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0095 0.0085
Brugia malayi laminin alpha chain 0.0048 0.0127 0.0384
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.013 0.3462
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.009 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0375 0.0995
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Brugia malayi tailless protein 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0084 0.025
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0084 0.025
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0084 0.025
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0015 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0084 0.025
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.0953 0.0944
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0095 0.0218
Brugia malayi hypothetical protein 0.002 0.0021 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0065 0.1336
Schistosoma mansoni lipoxygenase 0.0057 0.016 0.0369
Brugia malayi Cation transporter family protein 0.0019 0.0015 0.0035
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0049 0.013 0.0393
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0015 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.009 0.0216
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Trichomonas vaginalis rotamase, putative 0.0035 0.0074 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Toxoplasma gondii endonuclease IV APN 0.0078 0.0238 0.2557
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.001 0.0016
Brugia malayi steroid hormone receptor 0.0037 0.0084 0.025
Brugia malayi von Willebrand Factor 0.0049 0.013 0.0393
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0375 0.0995
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0127 0.0293
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0271 0.0832
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.093 0.2147
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0017 0.0066
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0375 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0238 0.6129
Echinococcus granulosus geminin 0.0175 0.0609 0.06
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.093 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0265 0.0813
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0084 0.0194
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0015 0.0035
Onchocerca volvulus 0.0029 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Schistosoma mansoni nuclear hormone receptor 0.0018 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Brugia malayi 6-phosphofructokinase 0.0114 0.0375 0.1155
Echinococcus multilocularis geminin 0.0175 0.0609 0.06
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.006 0.0134
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.0218
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0018 0.0008
Brugia malayi metabotropic glutamate receptor type 2 0.0045 0.0114 0.0343
Brugia malayi hypothetical protein 0.004 0.0095 0.0283
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0127 0.0118
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0095 0.0283
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0095 0.0085
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0114 0.0374 0.0365
Loa Loa (eye worm) DOMON domain-containing protein 0.0029 0.0052 0.0149
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0084 0.0194
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0095 0.0085
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0017 0.0767
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0084 0.0219
Toxoplasma gondii microneme protein MIC17B 0.0016 0.0004 0.0039
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0037 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Onchocerca volvulus 0.0029 0.0052 0.0131
Echinococcus granulosus transcription factor Dp 1 0.0039 0.009 0.008
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0103 0.0252
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0065 0.1727
Onchocerca volvulus 0.0019 0.0015 0.0031
Echinococcus granulosus expressed protein 0.0035 0.0074 0.0065
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.013 0.3462
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.006 0.0115
Echinococcus granulosus pikachurin 0.0048 0.0127 0.0118
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Entamoeba histolytica hypothetical protein 0.0039 0.009 0.2409
Schistosoma mansoni survival motor neuron protein 0.005 0.0135 0.0311
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0074 0.022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0084 0.025
Entamoeba histolytica hypothetical protein 0.004 0.0095 0.2521
Brugia malayi EGF-like domain containing protein 0.0048 0.0127 0.0384
Brugia malayi DOMON domain containing protein 0.0029 0.0052 0.0149
Brugia malayi DOMON domain containing protein 0.0029 0.0052 0.0149
Onchocerca volvulus 0.003 0.0056 0.0142
Toxoplasma gondii hypothetical protein 0.0016 0.0004 0.0039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0084 0.0075
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0091
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Trichomonas vaginalis rotamase, putative 0.0034 0.0071 0.0165
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0055 0.0159
Echinococcus granulosus dnaJ subfamily B 0.0423 0.155 0.1542
Schistosoma mansoni hypothetical protein 0.0049 0.013 0.03
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0084 0.025
Brugia malayi phosphofructokinase 0.0114 0.0375 0.1155
Toxoplasma gondii microneme protein MIC4 0.0016 0.0004 0.0039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0015 0.0035
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0015 0.0005
Schistosoma mansoni metabotropic glutamate receptor 0.0045 0.0114 0.0263
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.009 0.0216
Onchocerca volvulus 0.0049 0.013 0.0344
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0127 0.0384
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0119 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.02 0.0461
Brugia malayi CXXC zinc finger family protein 0.003 0.0056 0.0163
Onchocerca volvulus 0.0124 0.0415 0.1122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0084 0.0194
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0065 0.0524
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0046 0.0497
Plasmodium vivax hypothetical protein, conserved 0.0049 0.013 0.2837
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0375 1
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0084 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0084 0.025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0103
Schistosoma mansoni hypothetical protein 0.0423 0.155 0.358
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.006 0.0642
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.009 0.08
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0015 0.0005
Echinococcus multilocularis nAChR subunit 0.0019 0.0015 0.0005
Echinococcus granulosus collagen alpha 1VII chain 0.0049 0.013 0.012
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Onchocerca volvulus 0.0019 0.0015 0.0031
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0021 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.013 0.0393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0084 0.0075
Toxoplasma gondii subtilisin SUB12 0.0016 0.0004 0.0039
Schistosoma mansoni nAChR subunit 0.0019 0.0015 0.0035
Onchocerca volvulus 0.0049 0.013 0.0344
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0084 0.0194
Echinococcus granulosus intermediate filament protein 0.0086 0.0271 0.0262
Loa Loa (eye worm) hypothetical protein 0.0078 0.0238 0.0728
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0043
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0145 0.0441
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0015 0.0005
Echinococcus granulosus leukotriene A 4 hydrolase 0.024 0.0856 0.0847
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0015 0.0005
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0018
Echinococcus granulosus metabotropic glutamate receptor 2 0.0077 0.0236 0.0227
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0055 0.0589
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0103 0.0252
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0127 0.0118
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0037 0.0499
Mycobacterium ulcerans endonuclease IV 0.0078 0.0238 0.2469
Schistosoma mansoni regulator of G protein signaling 0.004 0.0095 0.0218
Brugia malayi hypothetical protein 0.0111 0.0363 0.1117
Brugia malayi Metabotropic glutamate receptor precursor. 0.0092 0.0293 0.0901
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0283
Plasmodium falciparum thrombospondin-related anonymous protein 0.0049 0.013 0.5111
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0093 0.3445
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0055 0.1714
Entamoeba histolytica hypothetical protein 0.0039 0.009 0.2409
Brugia malayi Kringle domain containing protein 0.0025 0.0037 0.0103
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0132
Schistosoma mansoni axis inhibition protein axin 0.004 0.0095 0.0218
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0077 0.0236 0.0227
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0015 0.0005
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0095 0.0085
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.006 0.0134
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.009 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0021 0.0105
Brugia malayi 6-phosphofructokinase 0.0114 0.0375 0.1155
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0883 0.0874
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.001 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0095 0.0218
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0393
Echinococcus granulosus metabotropic glutamate receptor 5 0.0114 0.0374 0.0365
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0084 0.0075
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0015 0.0005
Schistosoma mansoni rab6-interacting 0.002 0.0021 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0375 0.0995
Schistosoma mansoni rotamase 0.0035 0.0074 0.0172
Brugia malayi hypothetical protein 0.002 0.0018 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0046 0.0736
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.0105
Schistosoma mansoni cpg binding protein 0.003 0.0056 0.0129
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0055 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.093 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1205 0.4517 0.4512
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0016 0.0004 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0149 0.051 0.1575
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.024 0.0856 0.1976
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.093 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0095 0.0229
Echinococcus granulosus axis inhibition protein axin 0.004 0.0095 0.0085
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0095 0.0085
Schistosoma mansoni cell polarity protein 0.0048 0.0127 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0415 0.0958
Loa Loa (eye worm) glutamate receptor 0.0036 0.0081 0.024
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.009 0.008
Echinococcus granulosus expressed protein 0.0777 0.2893 0.2886
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0004 0.0039
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0197 0.0601
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0046 0.0818
Toxoplasma gondii PAN/Apple domain-containing protein 0.0016 0.0004 0.0039
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0015 0.0005
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0037 0.0396
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.009 0.008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0084 0.0075
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.006 0.0642
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.006 0.1937
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.006 0.6175
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.025
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0056 0.0163
Onchocerca volvulus 0.0018 0.001 0.0016
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0375 0.0995
Brugia malayi von Willebrand factor type A domain containing protein 0.0049 0.013 0.0393
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0049 0.013 0.5111
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.001 0.0018
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0015 0.0035
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0015 0.0035
Brugia malayi hypothetical protein 0.004 0.0095 0.0283
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0046 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0415 0.0406
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0018 0.0041
Schistosoma mansoni zinc finger protein 0.0018 0.001 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0015 0.0005
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0095 0.0283
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0049 0.013 0.1396
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0018 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.009 0.204
Trichomonas vaginalis set domain proteins, putative 0.0982 0.3669 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0084 0.025
Mycobacterium ulcerans hypothetical protein 0.002 0.0021 0.0105
Onchocerca volvulus 0.002 0.0021 0.0046
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0375 0.3921
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0127 0.0293
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0007
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0076 0.0231 0.0706
Loa Loa (eye worm) DOMON domain-containing protein 0.0029 0.0052 0.0149
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0095 0.0085
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0375 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.001 0.0018
Loa Loa (eye worm) DR-78 0.0018 0.001 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Schistosoma mansoni lamin 0.0086 0.0271 0.0626
Treponema pallidum hypothetical protein 0.0049 0.013 0.0249
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0149 0.051 0.1575
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0035
Schistosoma mansoni hypothetical protein 0.0175 0.0609 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0084 0.025
Loa Loa (eye worm) hypothetical protein 0.0149 0.051 0.1575
Loa Loa (eye worm) CUTiclin-Like family member 0.0049 0.013 0.0393
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.001 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0015 0.0035
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0017
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0055 0.5552
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.001 0.0016
Chlamydia trachomatis endonuclease IV 0.0078 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0052
Echinococcus multilocularis expressed protein 0.0035 0.0074 0.0065

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1000 nM Inhibitory activity against bovine adrenal dopamine beta-hydroxylase(DBH) ChEMBL. 2362264
IC50 (binding) = 1000 nM Inhibitory activity against bovine adrenal dopamine beta-hydroxylase(DBH) ChEMBL. 2362264

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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