Detailed information for compound 815104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.535 | Formula: C24H31N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.54 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1CN1CCc2n(CC1)c(nn2)C(C(C)C)NC(=O)c1cocc1
  • InChi: 1S/C24H31N5O3/c1-4-32-20-8-6-5-7-18(20)15-28-11-9-21-26-27-23(29(21)13-12-28)22(17(2)3)25-24(30)19-10-14-31-16-19/h5-8,10,14,16-17,22H,4,9,11-13,15H2,1-3H3,(H,25,30)
  • InChiKey: SMKXUACUFKKAHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0011 0.002 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0014
Brugia malayi hypothetical protein 0.012 0.0837 0.2445
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.008 0.0134
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.0326 0.0545
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.0326 0.0545
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0039 0.0066
Echinococcus granulosus tubulin gamma 1 chain 0.002 0.0086 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0025
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0014
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0285 0.3343
Schistosoma mansoni alpha tubulin 0.002 0.0086 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0307 0.2541
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.0326 0.0545
Echinococcus multilocularis hypothetical protein 0.002 0.0086 0.0144
Echinococcus multilocularis tubulin alpha chain 0.002 0.0086 0.0144
Echinococcus multilocularis dnaJ subfamily B 0.0801 0.5969 1
Schistosoma mansoni cpg binding protein 0.0056 0.0358 0.0599
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0014
Echinococcus granulosus tubulin alpha chain 0.002 0.0086 0.0144
Schistosoma mansoni hypothetical protein 0.0046 0.0283 0.0474
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.002 0.0166
Plasmodium falciparum alpha tubulin 1 0.002 0.0086 0.2648
Echinococcus multilocularis tubulin alpha chain 0.002 0.0086 0.0144
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.3423 0.5735
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Leishmania major beta tubulin 0.0052 0.0326 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0025
Echinococcus multilocularis beta tubulin 0.0052 0.0326 0.0545
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0065 0.0109
Schistosoma mansoni polycystin 1-related 0.0019 0.0078 0.0131
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0065 0.0109
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.008 0.0664
Schistosoma mansoni tubulin subunit alpha 0.002 0.0086 0.0144
Echinococcus granulosus intermediate filament protein 0.0079 0.0529 0.0887
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0011 0.002 0.0166
Leishmania major beta tubulin 0.0052 0.0326 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0052 0.0326 0.0951
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0398 0.1162
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0009 0 0.5
Loa Loa (eye worm) tubulin beta-4 chain 0.0052 0.0326 0.0951
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0285 0.0478
Trypanosoma cruzi epsilon tubulin, putative 0.002 0.0086 0.2648
Loa Loa (eye worm) BEN-1 protein 0.0052 0.0326 0.0951
Trichomonas vaginalis tubulin beta chain, putative 0.0011 0.002 0.0166
Trypanosoma brucei alpha tubulin 0.002 0.0086 0.2648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Loa Loa (eye worm) BEN-1 protein 0.0052 0.0326 0.0951
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0307 0.9427
Leishmania major beta tubulin 0.0052 0.0326 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.0326 0.0545
Schistosoma mansoni rab6-interacting 0.0019 0.0078 0.0131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0014
Echinococcus granulosus tubulin alpha chain 0.002 0.0086 0.0144
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.0247
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.1038 0.3031
Echinococcus granulosus RUN 0.0019 0.0078 0.0131
Echinococcus multilocularis cpg binding protein 0.0059 0.0382 0.064
Schistosoma mansoni cpg binding protein 0.0059 0.0382 0.064
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0234
Plasmodium vivax tubulin beta chain, putative 0.0052 0.0326 1
Echinococcus granulosus peroxisome assembly protein 26 0.002 0.0086 0.0144
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0228
Loa Loa (eye worm) intermediate filament protein 0.0079 0.0529 0.1546
Loa Loa (eye worm) hypothetical protein 0.0463 0.3423 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0837 0.2445
Leishmania major gamma-tubulin 0.002 0.0086 0.2648
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0014
Entamoeba histolytica tubulin family protein 0.0052 0.0326 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1319 0.221
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0358 0.1045
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0086 0.0144
Giardia lamblia Beta tubulin 0.0052 0.0326 1
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.0326 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0398 0.0666
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0737 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0078 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Toxoplasma gondii alpha tubulin TUBA1 0.002 0.0086 0.117
Brugia malayi mbt repeat family protein 0.0047 0.0285 0.0834
Loa Loa (eye worm) RecQ helicase 0.0019 0.008 0.0234
Echinococcus granulosus tubulin beta 1 chain 0.0052 0.0326 0.0545
Echinococcus granulosus tubulin alpha chain 0.002 0.0086 0.0144
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0086 0.2648
Trypanosoma cruzi alpha tubulin, putative 0.002 0.0086 0.2648
Schistosoma mansoni survival motor neuron protein 0.0094 0.0646 0.1081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0338 0.0566
Schistosoma mansoni lipoxygenase 0.0054 0.0338 0.0566
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0307 0.2541
Leishmania major beta tubulin 0.0052 0.0326 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0338 0.0566
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0086 0.0714
Echinococcus multilocularis lamin dm0 0.0079 0.0529 0.0887
Brugia malayi alpha-tubulin 0.002 0.0086 0.0252
Echinococcus granulosus tubulin epsilon chain 0.002 0.0086 0.0144
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0006 0.0172
Loa Loa (eye worm) tubulin beta chain 0.0052 0.0326 0.0951
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0307 0.0897
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Trypanosoma brucei beta tubulin 0.0052 0.0326 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Brugia malayi MAP kinase sur-1 0.005 0.0307 0.0897
Echinococcus multilocularis tubulin subunit TubB 0.002 0.0086 0.0144
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0086 0.0714
Onchocerca volvulus 0.0019 0.0078 0.0842
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Plasmodium falciparum alpha tubulin 2 0.002 0.0086 0.2648
Echinococcus granulosus tubulin beta 4A class IVa 0.0052 0.0326 0.0545
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Echinococcus granulosus tubulin alpha 0.002 0.0086 0.0144
Echinococcus multilocularis peroxisome assembly protein 26 0.002 0.0086 0.0144
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0014
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0307 0.9427
Echinococcus multilocularis tubulin gamma 1 chain 0.002 0.0086 0.0144
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0285 0.0478
Echinococcus granulosus tubulin alpha chain 0.002 0.0086 0.0144
Loa Loa (eye worm) alpha-tubulin 0.002 0.0086 0.0252
Leishmania major beta tubulin 0.0052 0.0326 1
Trichomonas vaginalis tubulin, putative 0.0011 0.002 0.0166
Giardia lamblia Beta tubulin 0.0052 0.0326 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0307 0.9427
Onchocerca volvulus 0.0056 0.0358 0.4214
Trypanosoma brucei alpha tubulin, putative 0.0011 0.002 0.0616
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0086 0.0144
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0014
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0078 0.0131
Brugia malayi CXXC zinc finger family protein 0.0056 0.0358 0.1045
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0283 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0025
Echinococcus granulosus neuropeptide s receptor 0.0456 0.3366 0.5639
Echinococcus multilocularis tubulin subunit beta 0.0052 0.0326 0.0545
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.1038 0.3031
Trypanosoma brucei beta tubulin 0.002 0.0086 0.2648
Brugia malayi tubulin alpha-2 chain 0.002 0.0086 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0398 0.0666
Trypanosoma brucei tubulin gamma chain 0.002 0.0086 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1208 1
Trypanosoma brucei epsilon tubulin 0.002 0.0086 0.2648
Echinococcus granulosus tar DNA binding protein 0.0062 0.0398 0.0666
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0014
Leishmania major beta tubulin 0.0052 0.0326 1
Trypanosoma brucei beta tubulin 0.0052 0.0326 1
Echinococcus multilocularis beta tubulin 0.0052 0.0326 0.0545
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.1038 0.3031
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0086 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.0079 0.0529 0.1546
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0086 0.0144
Echinococcus granulosus lamin 0.0079 0.0529 0.0887
Onchocerca volvulus 0.0019 0.0078 0.0842
Schistosoma mansoni intermediate filament proteins 0.0079 0.0529 0.0887
Trypanosoma brucei beta tubulin 0.0052 0.0326 1
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0086 0.0144
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0039 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0014
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0008 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0398 0.0666
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.008 0.2463
Trypanosoma brucei alpha tubulin 0.002 0.0086 0.2648
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0025
Brugia malayi mbt repeat family protein 0.0047 0.0285 0.0834
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0283 0.0827
Giardia lamblia Gamma tubulin 0.002 0.0086 0.2648
Leishmania major beta tubulin 0.0052 0.0326 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.002 0.0086 0.0252
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0334 0.0976
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0247
Leishmania major beta tubulin 0.0052 0.0326 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0014
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.008 0.0664
Loa Loa (eye worm) tubulin beta-2A chain 0.0052 0.0326 0.0951
Schistosoma mansoni hypothetical protein 0.0046 0.0283 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Leishmania major beta tubulin 0.0052 0.0326 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0078 0.0228
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0086 0.0144
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.5029 0.8425
Leishmania major beta tubulin 0.0052 0.0326 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.0801 0.5969 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0228
Echinococcus multilocularis tubulin alpha 0.002 0.0086 0.0144
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.008 0.0134
Brugia malayi tubulin alpha chain - mouse 0.002 0.0086 0.0252
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0114
Entamoeba histolytica recQ family DNA helicase 0.001 0.0008 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0025
Brugia malayi Tubulin beta chain 0.0011 0.002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0037 0.021 0.0614
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1336 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.012 0.0837 0.2445
Loa Loa (eye worm) tubulin alpha 2 0.0011 0.002 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0247
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0078 0.0131
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0086 0.0144
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0014
Echinococcus multilocularis lamin 0.0079 0.0529 0.0887
Trichomonas vaginalis tubulin, putative 0.0011 0.002 0.0166
Plasmodium falciparum tubulin beta chain 0.0052 0.0326 1
Schistosoma mansoni tubulin subunit alpha 0.002 0.0086 0.0144
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.008 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0025
Onchocerca volvulus 0.0079 0.0529 0.6285
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.008 0.2463
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Brugia malayi follicle stimulating hormone receptor 0.0454 0.3354 0.9799
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.0326 0.0545
Trypanosoma cruzi tubulin gamma chain 0.002 0.0086 0.2648
Schistosoma mansoni hypothetical protein 0.0046 0.0283 0.0474
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.0326 0.0545
Giardia lamblia Beta tubulin 0.0052 0.0326 1
Trypanosoma brucei alpha tubulin 0.002 0.0086 0.2648
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1319 0.221
Loa Loa (eye worm) RNA binding protein 0.0062 0.0398 0.1162
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0174 0.1244 0.3633
Leishmania major beta tubulin 0.0052 0.0326 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0307 0.9427
Schistosoma mansoni hypothetical protein 0.0046 0.0283 0.0474
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0014
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.008 0.0134
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.008 0.1088
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.002 0.0086 0.0714
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0307 0.0514
Echinococcus multilocularis tubulin beta 1 chain 0.0052 0.0326 0.0545
Schistosoma mansoni DNA helicase recq1 0.0019 0.008 0.0134
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0086 0.2648
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.008 0.0234
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0259
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.008 0.1088
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0688 0.2011
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0008 0.0259
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0025
Loa Loa (eye worm) tubulin alpha 2 0.0011 0.002 0.0059
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0334 0.056
Trypanosoma brucei alpha tubulin 0.002 0.0086 0.2648
Loa Loa (eye worm) hypothetical protein 0.0037 0.021 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0086 0.0144
Echinococcus granulosus GPCR family 2 0.0046 0.0283 0.0474
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0221 0.037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.008 0.0234
Leishmania major epsilon tubulin, putative 0.002 0.0086 0.2648
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0131
Entamoeba histolytica tubulin gamma chain 0.002 0.0086 0.252
Schistosoma mansoni alpha tubulin 0.002 0.0086 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0833 0.1395
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.008 0.0664
Schistosoma mansoni lamin 0.0079 0.0529 0.0887
Trichomonas vaginalis tubulin alpha chain, putative 0.002 0.0086 0.0714
Schistosoma mansoni loxhd1 0.0019 0.0078 0.0131
Echinococcus multilocularis musashi 0.0079 0.0529 0.0887
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1336 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0283 0.0474
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.008 0.0234
Onchocerca volvulus Huntingtin homolog 0.012 0.0837 1
Brugia malayi hypothetical protein 0.0019 0.0078 0.0228
Schistosoma mansoni tubulin subunit epsilon 0.002 0.0086 0.0144
Echinococcus granulosus tubulin subunit beta 0.0052 0.0326 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0025
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0334 0.056
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0334 0.056
Leishmania major beta tubulin 0.0052 0.0326 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.002 0.0086 0.117
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.002 0.0166
Schistosoma mansoni hypothetical protein 0.0094 0.0646 0.1081
Plasmodium vivax tubulin epsilon chain, putative 0.002 0.0086 0.2648
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0011 0.002 0.0166
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.3423 0.5735
Onchocerca volvulus Huntingtin homolog 0.012 0.0837 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Brugia malayi RNA binding protein 0.0062 0.0398 0.1162
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.0253 0.0738
Trichomonas vaginalis tubulin, putative 0.0052 0.0326 0.2696
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.008 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0283 0.0474
Schistosoma mansoni lipoxygenase 0.0019 0.0078 0.0131
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.008 0.2463
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0025
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0008 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0063 0.0185
Plasmodium falciparum tubulin gamma chain 0.002 0.0086 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0398 0.1162
Schistosoma mansoni tubulin subunit alpha 0.002 0.0086 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0398 0.0666
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0025
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0086 0.0252
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Mycobacterium ulcerans transcriptional regulator 0.1336 1 1
Schistosoma mansoni lamin 0.0079 0.0529 0.0887
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.008 0.2463
Onchocerca volvulus 0.0047 0.0285 0.3343
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0059
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0285 0.0478
Brugia malayi TAR-binding protein 0.0062 0.0398 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0086 0.0252
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0334 0.056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0086 0.0144
Echinococcus multilocularis bloom syndrome protein 0.0019 0.008 0.0134
Echinococcus granulosus dnaJ subfamily B 0.0801 0.5969 1
Entamoeba histolytica tubulin alpha-1 chain 0.002 0.0086 0.252
Brugia malayi hypothetical protein 0.0463 0.3423 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0221 0.037
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0307 0.9427
Schistosoma mansoni rab6-interacting 0.0019 0.0078 0.0131
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0307 0.9427
Trypanosoma brucei epsilon tubulin 0.002 0.0086 0.2648
Trypanosoma cruzi epsilon tubulin, putative 0.002 0.0086 0.2648
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0011 0.002 0.0059
Onchocerca volvulus 0.0079 0.0529 0.6285
Echinococcus granulosus lamin dm0 0.0079 0.0529 0.0887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0285 0.0834
Entamoeba histolytica recQ family helicase, putative 0.0019 0.008 0.2331
Loa Loa (eye worm) tubulin gamma chain 0.002 0.0086 0.0252
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.3366 0.5639
Toxoplasma gondii beta-tubulin, putative 0.0052 0.0326 0.4419
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.0529 0.1546
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0086 0.0144
Schistosoma mansoni tubulin subunit beta 0.0052 0.0326 0.0545
Leishmania major beta tubulin 0.0052 0.0326 1
Brugia malayi Tubulin alpha chain 0.002 0.0086 0.0252
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.3366 0.5639
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0014
Trichomonas vaginalis tubulin epsilon chain, putative 0.0052 0.0326 0.2696
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.002 0.0166
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.0326 0.0545
Leishmania major beta tubulin 0.0052 0.0326 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.008 0.2463
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0025
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0078 0.2402
Loa Loa (eye worm) hypothetical protein 0.0078 0.0518 0.1514
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Brugia malayi Tubulin beta-1 chain 0.0052 0.0326 0.0951
Echinococcus granulosus tubulin alpha chain 0.002 0.0086 0.0144
Giardia lamblia Alpha-tubulin 0.002 0.0086 0.2648
Loa Loa (eye worm) beta-tubulin 0.0052 0.0326 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0307 0.9427
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0078 0.0131
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0307 0.0514
Echinococcus granulosus beta tubulin 0.0052 0.0326 0.0545
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0086 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Leishmania major beta tubulin 0.0052 0.0326 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0646 0.1886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0025
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0398 0.0666
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0398 0.1162
Echinococcus multilocularis tubulin alpha chain 0.002 0.0086 0.0144
Brugia malayi beta-tubulin, identical 0.0052 0.0326 0.0951
Echinococcus granulosus beta tubulin 0.0052 0.0326 0.0545
Schistosoma mansoni alpha tubulin 0.002 0.0086 0.0144
Toxoplasma gondii alpha-tubulin I, putative 0.002 0.0086 0.117
Echinococcus multilocularis tubulin epsilon chain 0.002 0.0086 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0283 0.0474
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0086 0.0714
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0283 0.0474
Trypanosoma brucei protein kinase, putative 0.005 0.0307 0.9427
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0259
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0307 0.0514
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0398 0.0666
Schistosoma mansoni hypothetical protein 0.0284 0.2071 0.347
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0078 0.0131
Trichomonas vaginalis tubulin epsilon chain, putative 0.0052 0.0326 0.2696
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0307 0.2541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0014
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0025
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0285 0.0478
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0053 0.0334 0.0976
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.3366 0.5639
Echinococcus granulosus microtubule associated protein 2 0.0676 0.5029 0.8425
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0334 0.056
Brugia malayi Doublecortin family protein 0.0019 0.0078 0.0228
Schistosoma mansoni cpg binding protein 0.0059 0.0382 0.064
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0307 0.2541
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0065 0.019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0307 0.4166
Entamoeba histolytica tubulin family protein 0.0052 0.0326 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0307 0.0514
Plasmodium vivax tubulin gamma chain, putative 0.002 0.0086 0.2648
Echinococcus granulosus tubulin subunit TubB 0.002 0.0086 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0307 0.0514
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0014
Loa Loa (eye worm) alpha-tubulin 0.002 0.0086 0.0252
Echinococcus multilocularis GPCR, family 2 0.0046 0.0283 0.0474
Schistosoma mansoni tubulin subunit gamma 0.002 0.0086 0.0144
Loa Loa (eye worm) hypothetical protein 0.01 0.0688 0.2011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.008 0.2463
Echinococcus granulosus bloom syndrome protein 0.0019 0.008 0.0134
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0078 0.2402
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0052 0.0326 0.0545
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.01 0.0688 0.1153
Trichomonas vaginalis tubulin beta chain, putative 0.0052 0.0326 0.2696
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0454 0.3354 0.9799
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0025
Trypanosoma brucei epsilon tubulin 0.002 0.0086 0.2648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0247
Mycobacterium ulcerans TetR family transcriptional regulator 0.1336 1 1
Trypanosoma brucei beta tubulin 0.0052 0.0326 1
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.0253 0.0738
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0039 0.0066
Brugia malayi intermediate filament protein 0.0079 0.0529 0.1546
Leishmania major beta tubulin 0.0052 0.0326 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0285 0.0478
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0039 0.0066
Trichomonas vaginalis tubulin gamma chain, putative 0.0052 0.0326 0.2696
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0307 0.9427
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Echinococcus granulosus cpg binding protein 0.0059 0.0382 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0247
Echinococcus multilocularis RUN 0.0019 0.0078 0.0131
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.0529 0.1546
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0283 0.0827
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0086 0.0714
Trichomonas vaginalis tubulin alpha chain, putative 0.0052 0.0326 0.2696
Brugia malayi Tubulin gamma chain 0.002 0.0086 0.0252
Leishmania major beta tubulin 0.0052 0.0326 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0174 0.1244 0.3633
Echinococcus multilocularis tubulin alpha chain 0.002 0.0086 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0025
Toxoplasma gondii beta tubulin 0.0052 0.0326 0.4419
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0086 0.0714
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0086 0.0252
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.0326 0.0545
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0014
Schistosoma mansoni DNA helicase recq5 0.0019 0.008 0.0134
Trypanosoma cruzi beta tubulin, putative 0.0052 0.0326 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0078 0.0131
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0086 0.0144
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0086 0.0144
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0285 0.0834
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0014
Leishmania major beta tubulin 0.0052 0.0326 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0283 0.0827
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0076
Brugia malayi hypothetical protein 0.0019 0.0078 0.0228
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0086 0.0144
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0285 0.0478
Entamoeba histolytica tubulin alpha chain, putative 0.002 0.0086 0.252
Brugia malayi Tubulin alpha-2 chain 0.002 0.0086 0.0252
Toxoplasma gondii beta-1 tubulin, putative 0.0052 0.0326 0.4419
Brugia malayi Tubulin alpha-2 chain 0.002 0.0086 0.0252
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0285 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0025
Loa Loa (eye worm) MBCTL1 0.0053 0.0334 0.0976
Echinococcus granulosus alpha tubulin 0.002 0.0086 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0646
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.5029 0.8425
Onchocerca volvulus 0.0094 0.0646 0.769
Echinococcus multilocularis tubulin alpha chain 0.002 0.0086 0.0144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0014
Giardia lamblia Alpha-tubulin 0.002 0.0086 0.2648
Plasmodium falciparum tubulin epsilon chain, putative 0.002 0.0086 0.2648
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.0326 0.0545
Leishmania major alpha tubulin 0.002 0.0086 0.2648
Loa Loa (eye worm) hypothetical protein 0.0146 0.1038 0.3031
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.