Detailed information for compound 826482

Basic information

Technical information
  • TDR Targets ID: 826482
  • Name: 2-(2-chlorophenyl)-1-(2-methylpropyl)benzimid azole
  • MW: 284.783 | Formula: C17H17ClN2
  • H donors: 0 H acceptors: 1 LogP: 4.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c(nc2c1cccc2)c1ccccc1Cl)C
  • InChi: 1S/C17H17ClN2/c1-12(2)11-20-16-10-6-5-9-15(16)19-17(20)13-7-3-4-8-14(13)18/h3-10,12H,11H2,1-2H3
  • InChiKey: AMHKWBXBESGKMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-chlorophenyl)-1-isobutyl-benzimidazole
  • 2-(2-chlorophenyl)-1-isobutylbenzimidazole
  • T5457803
  • D011-4986
  • NCGC00114776-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0078 0.0117 1
Brugia malayi Prion-like- 0.0045 0.0049 0.0134
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0018 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0045 0.0391
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0208 0.039 0.0383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0015
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0032 0.0068
Brugia malayi serine/threonine kinase 12 0.0483 0.0965 0.3081
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0045 0.0391
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0045 0.0184
Trypanosoma cruzi polo-like protein kinase, putative 0.1448 0.2988 0.9584
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0106 0.0333
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0045 0.0128
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0188 0.0347 0.0487
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0027 0.0011 0.0006
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0052 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.1438 0.2048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Trypanosoma cruzi cytochrome P450, putative 0.034 0.0665 0.2108
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0191 0.0606
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.008 0.0234
Schistosoma mansoni vesicular amine transporter 0.0211 0.0395 0.0389
Entamoeba histolytica serine/threonine protein kinase, putative 0.1448 0.2988 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0045 0.0184
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0052 0.0132
Schistosoma mansoni glutamate receptor AMPA 0.0161 0.029 0.0283
Echinococcus granulosus contactin 0.0045 0.0049 0.006
Schistosoma mansoni chromobox protein 0.0073 0.0106 0.0099
Schistosoma mansoni cell adhesion molecule 0.0234 0.0443 0.0437
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0078 0.0117 0.1809
Echinococcus multilocularis glutamate receptor NMDA 0.0081 0.0123 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0472 0.156
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0212 0.0397 0.7288
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0191 0.062
Brugia malayi Glutamate receptor 1 precursor 0.0161 0.029 0.091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0033 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0052 0.0152
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Loa Loa (eye worm) cytochrome P450 0.0212 0.0397 0.1254
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0191 0.0581
Loa Loa (eye worm) hypothetical protein 0.0254 0.0485 0.1538
Brugia malayi glutathione reductase 0.0049 0.0055 0.0155
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0052 0.0166
Echinococcus multilocularis titin 0.0033 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0212 0.0397 0.7288
Loa Loa (eye worm) glutamate receptor 1 0.0161 0.029 0.091
Mycobacterium ulcerans glutaminase 0.0281 0.0541 0.8039
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0212 0.0397 0.7288
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0483 0.0965 0.3206
Schistosoma mansoni glutaminase 0.0281 0.0541 0.0535
Schistosoma mansoni hypothetical protein 0.0079 0.0118 0.0111
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0045 0.0537
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0095 0.0273
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0212 0.0397 0.7288
Loa Loa (eye worm) cytochrome P450 family protein 0.034 0.0665 0.2118
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0208 0.039 0.0548
Schistosoma mansoni protein kinase 0.0032 0.0021 0.0014
Leishmania major protein kinase, putative 0.0032 0.0021 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.004 0.0106
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0055 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0212 0.0397 0.7288
Schistosoma mansoni titin 0.0033 0.0023 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0045 0.0391
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0045 0.0391
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0045 0.0128
Trypanosoma cruzi aurora B kinase, putative 0.0483 0.0965 0.3073
Echinococcus multilocularis hemicentin 1 0.0045 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0045 0.0131
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0011 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0079 0.0118 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Trichomonas vaginalis AGC family protein kinase 0.0483 0.0965 0.3216
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0033 0.0089
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0018 0.0038
Onchocerca volvulus 0.0043 0.0045 0.0114
Schistosoma mansoni nephrin 0.0045 0.0049 0.0042
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.336 0.6993 1
Brugia malayi metabotropic glutamate receptor type 2 0.0027 0.0011 0.0012
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0212 0.0397 0.5755
Schistosoma mansoni lamin 0.0028 0.0012 0.0005
Echinococcus granulosus titin 0.0033 0.0023 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0045 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0106 0.0333
Echinococcus granulosus roundabout 2 0.0254 0.0485 0.0684
Schistosoma mansoni glutamate receptor AMPA 0.0161 0.029 0.0283
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0045 0.0121
Echinococcus multilocularis neuroglian 0.0228 0.0432 0.0608
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0023 0.0016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0188 0.0347 0.0487
Echinococcus multilocularis hemicentin 1 0.0045 0.0049 0.006
Schistosoma mansoni inositol monophosphatase 0.0038 0.0033 0.0026
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0033 0.0037
Mycobacterium tuberculosis Probable reductase 0.0111 0.0185 0.3149
Echinococcus granulosus defective proboscis extension response 0.0208 0.039 0.0548
Echinococcus granulosus hemicentin 1 0.0045 0.0049 0.006
Onchocerca volvulus Serine\/threonine kinase homolog 0.1448 0.2988 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0019 0.0017
Schistosoma mansoni protein kinase 0.0032 0.0021 0.0014
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0079 0.0118 0.0159
Leishmania major trypanothione reductase 0.0049 0.0055 0.0143
Loa Loa (eye worm) hypothetical protein 0.0772 0.157 0.5027
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0095 0.0127
Schistosoma mansoni ATP-binding cassette transporter 0.0161 0.029 0.0283
Schistosoma mansoni titin 0.0045 0.0049 0.0042
Brugia malayi Thioredoxin reductase 0.0049 0.0055 0.0155
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0185 0.3149
Loa Loa (eye worm) hypothetical protein 0.0128 0.0222 0.0692
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.047 0.1491
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0212 0.0397 0.5755
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0212 0.0397 0.7288
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0052 0.0132
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0079 0.0118 0.0159
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0212 0.0397 0.5755
Echinococcus multilocularis Immunoglobulin 0.0208 0.039 0.0548
Brugia malayi beta-lactamase 0.0043 0.0045 0.0121
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0045 0.0184
Schistosoma mansoni glutamate receptor kainate 0.0161 0.029 0.0283
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0018 0.0005
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0036 0.0041
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0212 0.0397 0.5755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Loa Loa (eye worm) hypothetical protein 0.006 0.008 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0536 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0032 0.0084
Echinococcus granulosus tyrosine kinase 0.0046 0.005 0.0062
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1448 0.2988 0.9585
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0212 0.0397 0.5755
Echinococcus multilocularis 0.0212 0.0397 0.0558
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0019 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0045 0.0288
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0039 0.0035 0.004
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0212 0.0397 0.5755
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0033 0.0037
Entamoeba histolytica protein kinase, putative 0.0483 0.0965 0.3206
Mycobacterium leprae Probable lipase LipE 0.0043 0.0045 0.0537
Schistosoma mansoni inositol monophosphatase 0.0038 0.0033 0.0026
Brugia malayi Inositol-1 0.0038 0.0033 0.0084
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0212 0.0397 0.5755
Echinococcus multilocularis lamin 0.0028 0.0012 0.0007
Mycobacterium ulcerans beta-lactamase 0.0043 0.0045 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Trypanosoma brucei cytochrome P450, putative 0.034 0.0665 0.2135
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0095 0.0285
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0027 0.0011 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Trypanosoma brucei aurora B kinase 0.0483 0.0965 0.3097
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0212 0.0397 0.7288
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0045 0.0049 0.006
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0027 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Loa Loa (eye worm) glutaminase 0.0281 0.0541 0.1719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Echinococcus multilocularis chromobox protein 1 0.0073 0.0106 0.0142
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0033 0.0072
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0483 0.0965 0.3206
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0037 0.0104
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0483 0.0965 0.3206
Brugia malayi intermediate filament protein 0.0028 0.0012 0.0015
Schistosoma mansoni tyrosine kinase 0.0046 0.005 0.0044
Plasmodium vivax glutathione reductase, putative 0.0049 0.0055 0.04
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0027 0.0011 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0191 0.062
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.1727 0.2462
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0032 0.0021 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Echinococcus granulosus metabotropic glutamate receptor 5 0.0027 0.0011 0.0006
Echinococcus multilocularis lamin dm0 0.0028 0.0012 0.0007
Toxoplasma gondii thioredoxin reductase 0.0049 0.0055 0.04
Brugia malayi protein unc-22 0.0033 0.0023 0.0051
Echinococcus multilocularis glutamate receptor 2 0.0109 0.0182 0.0251
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0191 0.0593
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0046 0.005 0.0133
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0212 0.0397 0.1244
Brugia malayi Pre-SET motif family protein 0.0217 0.0409 0.1292
Leishmania major hypothetical protein, conserved 0.003 0.0017 0.0021
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0191 0.0606
Schistosoma mansoni roundabout 0.0045 0.0049 0.0042
Loa Loa (eye worm) glutamate receptor 2 0.0161 0.029 0.091
Plasmodium falciparum serine/threonine protein kinase, putative 0.0483 0.0965 1
Echinococcus multilocularis twitchin 0.0033 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0039 0.0109
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0212 0.0397 0.5755
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0018 0.0005
Echinococcus granulosus tyrosine protein kinase Lyn 0.0032 0.0021 0.002
Echinococcus granulosus glutamate receptor 2 0.0109 0.0182 0.0251
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Mycobacterium ulcerans hypothetical protein 0.0043 0.0045 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0052 0.0152
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0208 0.039 0.0383
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0191 0.3261
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0035 0.009
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0045 0.0049 0.0127
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0274 0.0527 0.0744
Schistosoma mansoni protein kinase 0.0032 0.0021 0.0014
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0188 0.0347 0.0487
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0018 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0012 0.0015
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0212 0.0397 0.5755
Schistosoma mansoni protein kinase 0.0046 0.005 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0188 0.0347 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0025
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0012 0.0015
Brugia malayi Cytochrome P450 family protein 0.034 0.0665 0.2118
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0049 0.0134
Echinococcus multilocularis glutamate receptor 2 0.0188 0.0347 0.0487
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0052 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0045 0.0288
Loa Loa (eye worm) glutaminase 2 0.0281 0.0541 0.1719
Schistosoma mansoni glutamate receptor kainate 0.0161 0.029 0.0283
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0052 0.0166
Leishmania major C-8 sterol isomerase-like protein 0.151 0.3117 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Echinococcus multilocularis peroxidasin 0.0045 0.0049 0.006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0033 0.0165
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0045 0.0109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Brugia malayi Peroxidasin 0.0045 0.0049 0.0134
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0033 0.0037
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0483 0.0965 0.1372
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.0021
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Onchocerca volvulus 0.0043 0.0044 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0338 0.1111
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0045 0.0391
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0055 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Trypanosoma cruzi polo-like protein kinase, putative 0.1448 0.2988 0.9584
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0045 0.0038
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0021 0.0032
Loa Loa (eye worm) inositol-1 0.0038 0.0033 0.0084
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0188 0.0347 0.0487
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0212 0.0397 0.7288
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Schistosoma mansoni serine/threonine protein kinase 0.1448 0.2988 0.2983
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.005 0.014
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0191 0.0593
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0019 0.0017
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0017 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0017
Echinococcus granulosus tyrosine protein kinase otk 0.0045 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0034
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0033 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0191 0.062
Trypanosoma brucei trypanothione reductase 0.0049 0.0055 0.0177
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0055 0.0143
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0018 0.0005
Entamoeba histolytica protein kinase , putative 0.0483 0.0965 0.3206
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Schistosoma mansoni cell adhesion molecule 0.0045 0.0049 0.0042
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0033 0.0037
Leishmania major cytochrome p450-like protein 0.0212 0.0397 0.1244
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0212 0.0397 0.7288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0079 0.0118 0.0159
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0049 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0032 0.0084
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0035 0.009
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0052 0.0138
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0212 0.0397 0.1244
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0191 0.062
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0212 0.0397 0.5755
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0185 0.3149
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.034 0.0665 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0052 0.0045
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0011 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0028 0.0071
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0188 0.0347 0.0487
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0318 0.1032
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.0509 0.1614
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0191 0.0606
Echinococcus multilocularis Immunoglobulin 0.0208 0.039 0.0548
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0483 0.0965 1
Echinococcus granulosus lamin dm0 0.0028 0.0012 0.0007
Echinococcus multilocularis roundabout 2 0.0045 0.0049 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0483 0.0965 0.0959
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0039 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0212 0.0397 0.7288
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0338 0.1111
Entamoeba histolytica protein kinase domain containing protein 0.0483 0.0965 0.3206
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0032 0.0021 0.002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0052 0.0132
Giardia lamblia GTOR 0.0047 0.0052 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Giardia lamblia Aurora kinase 0.0483 0.0965 0.319
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0055 0.04
Echinococcus granulosus chromobox protein 1 0.0073 0.0106 0.0142
Mycobacterium tuberculosis Conserved protein 0.0043 0.0045 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0052 0.0144
Onchocerca volvulus 0.0033 0.0023 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0011 0.0006
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0011 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0212 0.0397 0.7288
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0019 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.008 0.0234
Loa Loa (eye worm) hypothetical protein 0.0234 0.0443 0.1403
Brugia malayi phosphofructokinase 0.0113 0.0191 0.0593
Onchocerca volvulus 0.1159 0.2381 0.7963
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0185 0.3149
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.1438 0.1432
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0045 0.0143
Loa Loa (eye worm) glutamate receptor 0.0027 0.0011 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.1411 0.2911 0.9337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0409 0.1292
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0095 0.0306
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0212 0.0397 0.1244
Echinococcus granulosus tumor protein p63 0.0353 0.0693 0.0981
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0191 0.4475
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0045 0.0128
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0049 0.006
Leishmania major cytochrome p450-like protein 0.034 0.0665 0.2108
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0095 0.0127
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.004 0.0033
Brugia malayi Receptor family ligand binding region containing protein 0.0046 0.005 0.014
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0033 0.0072
Mycobacterium tuberculosis Conserved protein 0.0043 0.0045 0.0391
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0191 0.2503
Onchocerca volvulus 0.0046 0.005 0.0133
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1448 0.2988 0.4266
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0052 0.0144
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0045 0.0391
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0032 0.0102
Brugia malayi Fibronectin type III domain containing protein 0.0208 0.039 0.1232
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.336 0.6993 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0212 0.0397 0.7288
Brugia malayi hypothetical protein 0.0208 0.039 0.1232
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0188 0.0347 0.0487
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0212 0.0397 0.5755
Onchocerca volvulus 0.0043 0.0045 0.0114
Brugia malayi serine/threonine-protein kinase 6 0.0483 0.0965 0.3081
Echinococcus multilocularis receptor type guanylyl cyclase 0.0046 0.005 0.0062
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0191 0.0264
Echinococcus granulosus activin receptor type 0.0032 0.0021 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Toxoplasma gondii aurora kinase 0.0483 0.0965 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0017
Echinococcus granulosus roundabout 2 0.0045 0.0049 0.006
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.0509 0.1614
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0039 0.0035 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0012 0.0015
Echinococcus granulosus peroxidasin 0.0045 0.0049 0.006
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0019 0.0038
Plasmodium vivax SET domain protein, putative 0.0031 0.0019 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0045 0.0038
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0212 0.0397 0.5755
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0032 0.0021 0.002
Giardia lamblia Kinase, PLK 0.1448 0.2988 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.005 0.014
Echinococcus granulosus glutamate receptor 2 0.0188 0.0347 0.0487
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0023 0.0051
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0052 0.0152
Plasmodium falciparum glutathione reductase 0.0049 0.0055 0.04
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0039 0.0095
Echinococcus multilocularis activin receptor type 0.0032 0.0021 0.002
Echinococcus multilocularis chromobox protein 1 0.0073 0.0106 0.0142
Echinococcus granulosus roundabout 2 0.0045 0.0049 0.006
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0045 0.0054
Echinococcus multilocularis nmda type glutamate receptor 0.0237 0.0451 0.0635
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0191 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.0021
Onchocerca volvulus Tyrosine kinase homolog 0.1198 0.2463 0.8236
Chlamydia trachomatis glutamine binding protein 0.0078 0.0117 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0078 0.0117 0.5724
Schistosoma mansoni tyrosine kinase 0.0064 0.0088 0.0082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0049 0.0134
Echinococcus granulosus twitchin 0.0241 0.0459 0.0647
Brugia malayi ERG2 and Sigma1 receptor like protein 0.151 0.3117 1
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0516 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Loa Loa (eye worm) beta-lactamase 0.0043 0.0045 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.004 0.0033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0059 0.0076 0.0223
Brugia malayi Heterochromatin protein 1 0.0073 0.0106 0.0318
Schistosoma mansoni cytochrome P450 0.0212 0.0397 0.039
Schistosoma mansoni protein kinase 0.0483 0.0965 0.0959
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0212 0.0397 0.7288
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0045 0.0121
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0212 0.0397 0.5755
Brugia malayi cytochrome P450 0.0212 0.0397 0.1254
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0033 0.0084
Echinococcus granulosus nmda type glutamate receptor 0.0237 0.0451 0.0635
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0212 0.0397 0.7288
Onchocerca volvulus 0.0043 0.0045 0.0114
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0212 0.0397 0.7288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0032 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0062 0.0055
Echinococcus multilocularis nmda type glutamate receptor 0.0108 0.018 0.0248
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0191 0.0264
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0212 0.0397 0.1244
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0045 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0019 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0211 0.3655
Schistosoma mansoni metabotropic glutamate receptor 0.0027 0.0011 0.0004
Entamoeba histolytica protein kinase, putative 0.0483 0.0965 0.3206
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0033 0.0089
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0033 0.0023 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0019
Echinococcus granulosus glutamate receptor NMDA 0.0081 0.0123 0.0166
Echinococcus granulosus Immunoglobulin 0.0208 0.039 0.0548
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0188 0.0347 0.0487
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0027 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0023 0.0016
Brugia malayi Glutamate receptor 2 precursor 0.0161 0.029 0.091
Brugia malayi Immunoglobulin I-set domain containing protein 0.0208 0.039 0.1232
Onchocerca volvulus 0.0032 0.002 0.0033
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0212 0.0397 0.5755
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0045 0.0049 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0055 0.0599
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0212 0.0397 0.7288
Trypanosoma cruzi C-8 sterol isomerase, putative 0.151 0.3117 1
Trichomonas vaginalis esterase, putative 0.0043 0.0045 0.0128
Brugia malayi beta-lactamase family protein 0.0043 0.0045 0.0121
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0185 0.3149
Loa Loa (eye worm) cytochrome P450 family protein 0.077 0.1566 0.5015
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0018 0.0024
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0191 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Schistosoma mansoni septate junction protein 0.0045 0.0049 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0212 0.0397 0.7288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Brugia malayi beta-lactamase family protein 0.0043 0.0045 0.0121
Schistosoma mansoni septate junction protein 0.0045 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0103
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0036 0.0041
Echinococcus granulosus cytochrome P450 2K1 0.0212 0.0397 0.0558
Onchocerca volvulus 0.0028 0.0012 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0161 0.029 0.0405
Schistosoma mansoni hypothetical protein 0.0212 0.0397 0.039
Leishmania major protein kinase, putative 0.0483 0.0965 0.3073
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Toxoplasma gondii cytochrome p450 superfamily protein 0.0212 0.0397 0.4006
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0212 0.0397 0.5755
Echinococcus granulosus titin 0.0033 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Echinococcus granulosus receptor type guanylyl cyclase 0.0046 0.005 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.0509 0.1685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.034 0.0665 0.2108
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0079 0.0118 0.0159
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0049 0.0134
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0078 0.0117 0.5724
Schistosoma mansoni hypothetical protein 0.0041 0.004 0.0033
Echinococcus granulosus microtubule associated protein 2 0.0708 0.1438 0.2048
Onchocerca volvulus 0.0028 0.0012 0.0003
Onchocerca volvulus 0.0052 0.0062 0.0171
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1411 0.2911 0.9337
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0211 0.5016
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0049 0.0042
Echinococcus granulosus nmda type glutamate receptor 0.0108 0.018 0.0248
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0045 0.0391
Schistosoma mansoni glutamate receptor kainate 0.0161 0.029 0.0283
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0106 0.0318
Brugia malayi 6-phosphofructokinase 0.0113 0.0191 0.0593
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0045 0.0109
Entamoeba histolytica protein kinase domain containing protein 0.0032 0.0021 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0211 0.3655
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0021 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0483 0.0965 0.3216
Echinococcus multilocularis NMDA receptor 0.0079 0.0118 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0052 0.0138
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0191 0.0185
Echinococcus granulosus intermediate filament protein 0.0028 0.0012 0.0007
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0021 0.0066
Echinococcus multilocularis aurora kinase A 0.0483 0.0965 0.1372
Onchocerca volvulus 0.0247 0.0472 0.1548
Loa Loa (eye worm) TK protein kinase 0.0039 0.0035 0.009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0211 0.3655
Plasmodium falciparum thioredoxin reductase 0.0049 0.0055 0.04
Loa Loa (eye worm) AUR protein kinase 0.0483 0.0965 0.3081
Loa Loa (eye worm) cytochrome P450 family protein 0.034 0.0665 0.2118
Echinococcus multilocularis tumor protein p63 0.0353 0.0693 0.0981
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0079 0.0118 0.0159
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0212 0.0397 0.5755
Echinococcus granulosus neuroglian 0.0045 0.0049 0.006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0095 0.0089
Echinococcus granulosus glutamate NMDA receptor subunit 0.0274 0.0527 0.0744
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0033 0.0089
Brugia malayi serine/threonine-protein kinase plk-2 0.1448 0.2988 0.9585
Echinococcus multilocularis neuroglian 0.0045 0.0049 0.006
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0095 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0483 0.0965 0.3216
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0121
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0038
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0234 0.0443 0.0625
Mycobacterium leprae putative cytochrome p450 0.0212 0.0397 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0027 0.0011 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Brugia malayi 6-phosphofructokinase 0.0113 0.0191 0.0593
Schistosoma mansoni tyrosine kinase 0.0046 0.005 0.0044
Schistosoma mansoni cell adhesion molecule 0.0045 0.0049 0.0042
Echinococcus granulosus lachesin 0.0045 0.0049 0.006
Echinococcus granulosus aurora kinase A 0.0483 0.0965 0.1372
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0095 0.0273
Loa Loa (eye worm) AUR protein kinase 0.0483 0.0965 0.3081
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0212 0.0397 0.1274
Trypanosoma brucei protein kinase, putative 0.0032 0.0021 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0017 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0045 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0014 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0012 0.0019
Schistosoma mansoni intermediate filament proteins 0.0028 0.0012 0.0005
Trypanosoma brucei polo-like protein kinase 0.1448 0.2988 0.9586
Leishmania major cytochrome p450-like protein 0.0212 0.0397 0.1244
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0049 0.006
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0212 0.0397 0.7288
Brugia malayi glutaminase DH11.1 0.0281 0.0541 0.1719
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1448 0.2988 0.9584
Trichomonas vaginalis CAMK family protein kinase 0.1448 0.2988 1
Schistosoma mansoni neuroglian 0.0045 0.0049 0.0042
Echinococcus granulosus neuroglian 0.0228 0.0432 0.0608
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0185 0.432
Echinococcus multilocularis tyrosine kinase 0.0046 0.005 0.0062
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0055 0.0155
Brugia malayi Cytochrome P450 family protein 0.077 0.1566 0.5015
Schistosoma mansoni metabotropic glutamate receptor 0.0027 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0045 0.0117
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0157 0.0282 0.0393
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0016 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0185 0.3149
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0033 0.5
Loa Loa (eye worm) hypothetical protein 0.0254 0.0485 0.1538
Brugia malayi Cytochrome P450 family protein 0.034 0.0665 0.2118
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0045 0.0049 0.006
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0049 0.006
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0191 0.0593
Schistosoma mansoni chromobox protein 0.0073 0.0106 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.005 0.014
Trypanosoma brucei C-8 sterol isomerase, putative 0.151 0.3117 1
Echinococcus multilocularis lachesin 0.0045 0.0049 0.006
Schistosoma mansoni lamin 0.0028 0.0012 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0028 0.0071
Loa Loa (eye worm) AUR protein kinase 0.0483 0.0965 0.3081
Schistosoma mansoni nephrin 0.0228 0.0432 0.0425
Echinococcus granulosus lamin 0.0028 0.0012 0.0007
Loa Loa (eye worm) CAMK protein kinase 0.0033 0.0023 0.0051
Echinococcus multilocularis roundabout 2 0.0045 0.0049 0.006
Brugia malayi chromobox protein homolog 3 0.0041 0.0039 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0044 0.0037
Loa Loa (eye worm) CYP4Cod1 0.034 0.0665 0.2118
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0018 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0095 0.0273
Leishmania major hypothetical protein, conserved 0.0043 0.0045 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0049 0.0134
Loa Loa (eye worm) hypothetical protein 0.0046 0.005 0.014
Loa Loa (eye worm) hypothetical protein 0.0208 0.039 0.1232
Schistosoma mansoni cell adhesion molecule 0.0045 0.0049 0.0042
Echinococcus multilocularis musashi 0.0028 0.0012 0.0007
Echinococcus granulosus chromobox protein 1 0.0073 0.0106 0.0142
Brugia malayi hypothetical protein 0.003 0.0017 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0212 0.0397 0.7288
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0033 0.0106
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1448 0.2988 0.4266
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0045 0.0049 0.0042
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0212 0.0397 0.5755
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0078 0.0117 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0176
Loa Loa (eye worm) glutathione reductase 0.0049 0.0055 0.0155
Mycobacterium leprae Conserved hypothetical protein 0.0212 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.151 0.3117 1
Brugia malayi serine/threonine protein kinase 6 0.0483 0.0965 0.3081
Schistosoma mansoni glutamate receptor NMDA 0.0274 0.0527 0.052
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0191 0.0614
Echinococcus multilocularis roundabout 2 0.0254 0.0485 0.0684
Trichomonas vaginalis AGC family protein kinase 0.0483 0.0965 0.3216
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0212 0.0397 0.5755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0032 0.0084
Echinococcus granulosus metabotropic glutamate receptor 2 0.0027 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0106
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0191 0.0185
Brugia malayi follicle stimulating hormone receptor 0.0247 0.047 0.1491
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0483 0.0965 0.1372
Trichomonas vaginalis glutaminase, putative 0.0281 0.0541 0.1794
Brugia malayi Guanylyl cyclase protein 23 0.0046 0.005 0.014
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0052 0.0064
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0079 0.0118 0.0159
Plasmodium falciparum protein kinase, putative 0.0032 0.0021 0.0035
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0212 0.0397 0.5755
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0212 0.0397 0.7288
Brugia malayi hypothetical protein 0.0027 0.0011 0.0012
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0018 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.0044
Echinococcus multilocularis tyrosine protein kinase otk 0.0045 0.0049 0.006
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0212 0.0397 0.5755
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0095 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.008 0.0234
Brugia malayi Cytochrome P450 family protein 0.0212 0.0397 0.1254
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0033 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0018 0.0038
Mycobacterium tuberculosis Conserved protein 0.0043 0.0045 0.0391
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0318 0.1045

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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