Detailed information for compound 829331

Basic information

Technical information
  • TDR Targets ID: 829331
  • Name: 2-[methyl-(7-methyl-5-oxo-[1,3,4]thiadiazolo[ 4,5-a]pyrimidin-2-yl)amino]-N-(3-propan-2-ylo xypropyl)acetamide
  • MW: 353.44 | Formula: C15H23N5O3S
  • H donors: 1 H acceptors: 2 LogP: 0.97 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(c1nn2c(s1)nc(cc2=O)C)C)NCCCOC(C)C
  • InChi: 1S/C15H23N5O3S/c1-10(2)23-7-5-6-16-12(21)9-19(4)15-18-20-13(22)8-11(3)17-14(20)24-15/h8,10H,5-7,9H2,1-4H3,(H,16,21)
  • InChiKey: CFRJJBDRDFERBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-isopropoxypropyl)-2-[methyl-(7-methyl-5-oxo-[1,3,4]thiadiazolo[4,5-a]pyrimidin-2-yl)amino]acetamide
  • N-(3-isopropoxypropyl)-2-[(5-keto-7-methyl-[1,3,4]thiadiazolo[4,5-a]pyrimidin-2-yl)-methyl-amino]acetamide
  • 2-[methyl-(7-methyl-5-oxo-[1,3,4]thiadiazolo[4,5-a]pyrimidin-2-yl)amino]-N-(3-propan-2-yloxypropyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thymidylate synthase 0.0231 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0099 0.0241 0.0241
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Brugia malayi notch-like transmembrane receptor 0.0174 0.0451 0.045
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0088 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0217 0.0216
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0045 0.0044
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Loa Loa (eye worm) notch protein 0.0174 0.0451 0.0451
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0217 0.0216
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0325 0.0876 0.0875
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0263 0.0702 0.0701
Onchocerca volvulus 0.0424 0.1157 0.194
Loa Loa (eye worm) PAN domain-containing protein 0.0424 0.1157 0.1157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0049 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0014 0.0012
Brugia malayi CUB domain containing protein 0.0205 0.0538 0.0537
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Schistosoma mansoni flap endonuclease-1 0.0027 0.0037 0.0036
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0205 0.0538 0.0537
Onchocerca volvulus 0.0547 0.1504 0.2529
Brugia malayi Kelch motif family protein 0.0205 0.0538 0.0537
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0702 0.0701
Brugia malayi CUB domain containing protein 0.0205 0.0538 0.0537
Schistosoma mansoni notch 0.0174 0.0451 0.045
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0049 0.0047
Echinococcus multilocularis slit 2 protein 0.0174 0.0451 0.045
Echinococcus granulosus microtubule associated protein 2 0.1376 0.3844 0.3843
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Brugia malayi Flap endonuclease-1 0.003 0.0045 0.0044
Loa Loa (eye worm) CUB domain-containing protein 0.0205 0.0538 0.0538
Echinococcus multilocularis microtubule associated protein 2 0.1376 0.3844 0.3843
Brugia malayi CHE-14 protein 0.1464 0.4093 0.4093
Echinococcus granulosus fibropellin Ia 0.0174 0.0451 0.045
Echinococcus granulosus dnaJ subfamily B 0.0475 0.13 0.1299
Brugia malayi hypothetical protein 0.0547 0.1504 0.1503
Echinococcus multilocularis Niemann Pick C1 protein 0.1464 0.4093 0.4093
Schistosoma mansoni hypothetical protein 0.0547 0.1504 0.1503
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0263 0.0702 0.0701
Brugia malayi Trypsin family protein 0.0547 0.1504 0.1503
Schistosoma mansoni hypothetical protein 0.0473 0.1297 0.1295
Schistosoma mansoni hypothetical protein 0.0473 0.1297 0.1295
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.011 0.027 0.0268
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0094 0.0225 0.3676
Echinococcus granulosus X box binding protein 1 0.0334 0.0904 0.0902
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0547 0.1504 0.1503
Loa Loa (eye worm) hypothetical protein 0.1618 0.4528 0.4528
Schistosoma mansoni hypothetical protein 0.0068 0.0152 0.015
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0424 0.1157 0.1957
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0205 0.0538 0.0538
Onchocerca volvulus 0.0424 0.1157 0.194
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0205 0.0538 0.0537
Echinococcus granulosus neurogenic locus notch protein 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus multilocularis notch 0.0174 0.0451 0.045
Echinococcus granulosus neural cadherin 0.0174 0.0451 0.045
Brugia malayi Trypsin family protein 0.0547 0.1504 0.1503
Loa Loa (eye worm) dihydrofolate reductase 0.0094 0.0225 0.0225
Brugia malayi basement membrane proteoglycan precursor 0.0263 0.0702 0.0701
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0263 0.0702 0.1169
Chlamydia trachomatis dihydrofolate reductase 0.0094 0.0225 1
Schistosoma mansoni hypothetical protein 0.0205 0.0538 0.0537
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0045 0.0044
Onchocerca volvulus 0.0424 0.1157 0.194
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Echinococcus granulosus sterol regulatory element binding protein 0.1464 0.4093 0.4093
Echinococcus multilocularis dihydrofolate reductase 0.0094 0.0225 0.0224
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0231 0.0611 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Toxoplasma gondii PAN/Apple domain-containing protein 0.0424 0.1157 0.1957
Loa Loa (eye worm) hypothetical protein 0.0379 0.1029 0.1029
Echinococcus granulosus neurogenic locus notch protein 0.0174 0.0451 0.045
Brugia malayi astacin protease protein 30 0.0205 0.0538 0.0537
Loa Loa (eye worm) PAN domain-containing protein 0.0424 0.1157 0.1157
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0263 0.0702 0.0701
Echinococcus multilocularis neurogenic locus protein delta 0.0174 0.0451 0.045
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0001 0.0001
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0205 0.0538 0.0537
Echinococcus multilocularis protein dispatched 1 0.1464 0.4093 0.4093
Brugia malayi Cadherin domain containing protein 0.0174 0.0451 0.045
Onchocerca volvulus 0.2107 0.5907 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Echinococcus granulosus GPCR family 2 0.0031 0.0049 0.0047
Onchocerca volvulus 0.0263 0.0702 0.1169
Toxoplasma gondii calcium binding egf domain-containing protein 0.0456 0.1247 0.2109
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0001 0.0022
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0547 0.1504 0.1503
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Echinococcus multilocularis CUB 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Schistosoma mansoni cpg binding protein 0.0033 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0068 0.0152 0.0152
Echinococcus granulosus tissue type plasminogen activator 0.2107 0.5907 0.5906
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Schistosoma mansoni egf-like domain protein 0.0456 0.1247 0.1245
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0174 0.0451 0.045
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0001 0.0001
Giardia lamblia High cysteine protein 0.0174 0.0451 0.0877
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0001 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0217 0.0217
Brugia malayi Calcium binding EGF domain containing protein 0.0174 0.0451 0.045
Echinococcus granulosus basement membrane specific heparan sulfate 0.0263 0.0702 0.0701
Brugia malayi CUB domain containing protein 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Mycobacterium ulcerans thymidylate synthase 0.0231 0.0611 0.0611
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.066 0.1824 0.1824
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0538 0.1065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0138 0.0232
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Loa Loa (eye worm) PAN domain-containing protein 0.0424 0.1157 0.1157
Echinococcus multilocularis thymidylate synthase 0.0231 0.0611 0.061
Loa Loa (eye worm) hypothetical protein 0.0923 0.2567 0.2567
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0049 0.0047
Brugia malayi hypothetical protein 0.0205 0.0538 0.0537
Onchocerca volvulus 0.1444 0.4037 0.6827
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Schistosoma mansoni hypothetical protein 0.0031 0.0049 0.0047
Onchocerca volvulus 0.0174 0.0451 0.0742
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1669 0.467 1
Onchocerca volvulus 0.0205 0.0538 0.089
Echinococcus multilocularis low density lipoprotein receptor protein 0.0263 0.0702 0.0701
Brugia malayi Calcium binding EGF domain containing protein 0.0456 0.1247 0.1245
Echinococcus granulosus cpg binding protein 0.0035 0.0059 0.0058
Brugia malayi CXXC zinc finger family protein 0.0033 0.0054 0.0053
Loa Loa (eye worm) bone morphogenetic protein 1b 0.066 0.1824 0.1824
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Mycobacterium ulcerans hypothetical protein 0.0019 0.0014 0.0014
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0456 0.1247 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0217 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0001 0.0022
Onchocerca volvulus 0.0424 0.1157 0.194
Onchocerca volvulus Arrow homolog 0.0719 0.1989 0.3352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Onchocerca volvulus 0.0547 0.1504 0.2529
Schistosoma mansoni notch 0.0174 0.0451 0.045
Toxoplasma gondii microneme protein MIC17A 0.0424 0.1157 0.1957
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1015 0.2824 0.2823
Echinococcus granulosus neuropeptide receptor A26 0.0756 0.2093 0.2092
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0014 0.0012
Schistosoma mansoni hypothetical protein 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0456 0.1247 0.1247
Echinococcus multilocularis glycoprotein Antigen 5 0.0547 0.1504 0.1503
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.3557 1 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0001 0.0001
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0702 0.0701
Onchocerca volvulus 0.0547 0.1504 0.2529
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Hypothetical protein 0.011 0.027 0.4414
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0001 0.0001
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0014 0.0222
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0325 0.0876 0.1484
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Entamoeba histolytica Flap nuclease, putative 0.003 0.0045 1
Echinococcus granulosus protein jagged 2 0.0174 0.0451 0.045
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0325 0.0876 0.0875
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0547 0.1504 0.1503
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0031 0.0049 0.0047
Onchocerca volvulus Slit protein homolog 0.0174 0.0451 0.0742
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0049 0.0047
Loa Loa (eye worm) PAN domain-containing protein 0.0424 0.1157 0.1157
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Echinococcus multilocularis Tolloid protein 1 0.066 0.1824 0.1823
Brugia malayi Protein kinase domain containing protein 0.2107 0.5907 0.5906
Schistosoma mansoni septate junction protein 0.0174 0.0451 0.045
Brugia malayi dihydrofolate reductase family protein 0.0094 0.0225 0.0224
Echinococcus multilocularis cubilin 0.0205 0.0538 0.0537
Loa Loa (eye worm) DOMON domain-containing protein 0.1444 0.4037 0.4037
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1464 0.4093 0.4093
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0205 0.0538 0.0538
Onchocerca volvulus 0.0263 0.0702 0.1169
Schistosoma mansoni hypothetical protein 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.1464 0.4093 0.4093
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.3557 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0752 0.2082 0.2081
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0094 0.0225 0.369
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0014 0.0012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0049 0.0047
Echinococcus granulosus flap endonuclease 1 0.003 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Loa Loa (eye worm) Notch2 0.0174 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Echinococcus multilocularis cpg binding protein 0.0035 0.0059 0.0058
Brugia malayi thymidylate synthase 0.0231 0.0611 0.061
Echinococcus granulosus Niemann Pick C1 protein 0.1464 0.4093 0.4093
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0174 0.0451 0.045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0014 0.02
Echinococcus multilocularis fibrillin 1 0.0456 0.1247 0.1245
Brugia malayi Nematode astacin protease protein 30 0.0205 0.0538 0.0537
Echinococcus multilocularis neurogenic locus notch protein 0.0174 0.0451 0.045
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0019 0.0033
Loa Loa (eye worm) cytochrome P450 0.0015 0.0001 0.0001
Brugia malayi Trypsin family protein 0.0547 0.1504 0.1503
Onchocerca volvulus 0.0205 0.0538 0.089
Onchocerca volvulus Putative cubilin 0.0379 0.1029 0.1723
Brugia malayi Nematode astacin protease protein 30 0.0205 0.0538 0.0537
Echinococcus granulosus glycoprotein Antigen 5 0.0547 0.1504 0.1503
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0014 0.0014
Echinococcus granulosus thymidylate synthase 0.0231 0.0611 0.061
Toxoplasma gondii calcium binding egf domain-containing protein 0.0456 0.1247 0.2109
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0325 0.0876 0.1484
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0702
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0014 0.0014
Echinococcus granulosus laminin 0.0456 0.1247 0.1245
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.13 0.1299
Toxoplasma gondii microneme protein MIC4 0.0424 0.1157 0.1957
Loa Loa (eye worm) hypothetical protein 0.0468 0.128 0.128
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.1444 0.4037 0.4036
Onchocerca volvulus 0.0424 0.1157 0.194
Onchocerca volvulus 0.0263 0.0702 0.1169
Onchocerca volvulus 0.0263 0.0702 0.1169
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Schistosoma mansoni notch 0.0174 0.0451 0.045
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957
Brugia malayi hypothetical protein 0.011 0.027 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0014 0.0222
Loa Loa (eye worm) TK/ROR protein kinase 0.2107 0.5907 0.5907
Schistosoma mansoni hypothetical protein 0.0031 0.0049 0.0047
Echinococcus granulosus protein jagged 1 0.0174 0.0451 0.045
Echinococcus granulosus neurogenic locus protein delta 0.0174 0.0451 0.045
Brugia malayi Cytochrome P450 family protein 0.0045 0.0088 0.0086
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0325 0.0876 0.0875
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0001 0.0001
Echinococcus granulosus protein jagged 2 0.0174 0.0451 0.045
Echinococcus granulosus notch 0.0174 0.0451 0.045
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0702
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.066 0.1824 0.1823
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0045 0.0074
Echinococcus multilocularis laminin 0.0456 0.1247 0.1245
Toxoplasma gondii kringle domain-containing protein 0.2107 0.5907 1
Toxoplasma gondii EGF family domain-containing protein 0.0174 0.0451 0.0761
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0045 0.0045
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Toxoplasma gondii microneme protein, putative 0.0424 0.1157 0.1957
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0159 0.0158
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0547 0.1504 0.1503
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0001 0.0022
Onchocerca volvulus 0.0424 0.1157 0.194
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0045 0.0077
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0547 0.1504 0.2529
Brugia malayi Calcium binding EGF domain containing protein 0.0174 0.0451 0.045
Echinococcus multilocularis geminin 0.0473 0.1297 0.1295
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0205 0.0538 0.0537
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Onchocerca volvulus 0.0231 0.0611 0.1014
Toxoplasma gondii microneme protein MIC17B 0.0424 0.1157 0.1957
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0001 0.0022
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Echinococcus granulosus CUB 0.0205 0.0538 0.0537
Onchocerca volvulus 0.0424 0.1157 0.194
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0263 0.0702 0.0701
Echinococcus multilocularis transmembrane protease serine 3 0.0547 0.1504 0.1503
Onchocerca volvulus 0.1444 0.4037 0.6827
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Schistosoma mansoni hypothetical protein 0.0334 0.0904 0.0902
Echinococcus multilocularis neural cadherin 0.0174 0.0451 0.045
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Echinococcus granulosus enteropeptidase 0.0547 0.1504 0.1503
Echinococcus granulosus low density lipoprotein receptor ldl 0.0263 0.0702 0.0701
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0217 0.0216
Onchocerca volvulus 0.0424 0.1157 0.194
Echinococcus multilocularis tissue type plasminogen activator 0.2107 0.5907 0.5906
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Onchocerca volvulus 0.0547 0.1504 0.2529
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0205 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1669 0.467 1
Onchocerca volvulus 0.0424 0.1157 0.194
Brugia malayi Lectin C-type domain containing protein 0.0205 0.0538 0.0537
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0001 0.0022
Echinococcus multilocularis protein jagged 1 0.0174 0.0451 0.045
Schistosoma mansoni notch 0.0174 0.0451 0.045
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0001 0.0001
Echinococcus granulosus slit 2 protein 0.0174 0.0451 0.045
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0001 0.0022
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Schistosoma mansoni cpg binding protein 0.0035 0.0059 0.0058
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0001 0.0022
Onchocerca volvulus 0.0424 0.1157 0.194
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0719 0.1989 0.1989
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Echinococcus multilocularis neuropeptide s receptor 0.0756 0.2093 0.2092
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0001 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0014 0.0014
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0456 0.1247 0.1247
Schistosoma mansoni hypothetical protein 0.2107 0.5907 0.5906
Onchocerca volvulus 0.0263 0.0702 0.1169
Schistosoma mansoni cell polarity protein 0.0174 0.0451 0.045
Onchocerca volvulus 0.0174 0.0451 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0152 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0217 0.0216
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Loa Loa (eye worm) hypothetical protein 0.3557 1 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0702 0.0701
Echinococcus multilocularis flap endonuclease 1 0.003 0.0045 0.0044
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0001 0.0001
Echinococcus multilocularis fibropellin Ia 0.0174 0.0451 0.045
Echinococcus multilocularis neurogenic locus notch protein 0.0174 0.0451 0.045
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0001 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0217 0.0216
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0205 0.0538 0.0537
Schistosoma mansoni hypothetical protein 0.0205 0.0538 0.0537
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus multilocularis neuropeptide receptor A26 0.0756 0.2093 0.2092
Brugia malayi Delta serrate ligand family protein 0.0174 0.0451 0.045
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0014 0.0014
Onchocerca volvulus 0.0424 0.1157 0.194
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1669 0.467 1
Onchocerca volvulus 0.0033 0.0054 0.0069
Echinococcus granulosus Tolloid protein 1 0.066 0.1824 0.1823
Echinococcus granulosus Mastin 0.0547 0.1504 0.1503
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0205 0.0538 0.0537
Plasmodium falciparum cysteine repeat modular protein 1 0.2107 0.5907 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0241 0.0241
Echinococcus multilocularis sterol regulatory element binding protein 0.1464 0.4093 0.4093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0217 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0014 0.0012
Schistosoma mansoni dihydrofolate reductase 0.0094 0.0225 0.0224
Echinococcus granulosus neuropeptide s receptor 0.0756 0.2093 0.2092
Brugia malayi Trypsin-like protease protein 5 0.0547 0.1504 0.1503
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Brugia malayi GCC2 and GCC3 family protein 0.0174 0.0451 0.045
Echinococcus granulosus geminin 0.0473 0.1297 0.1295
Onchocerca volvulus 0.0263 0.0702 0.1169
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.3557 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0059 0.0058
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0019 0.003
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.3557 1 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Loa Loa (eye worm) PAN domain-containing protein 0.0424 0.1157 0.1157
Brugia malayi hypothetical protein 0.0021 0.0019 0.0018
Echinococcus multilocularis X box binding protein 1 0.0334 0.0904 0.0902
Echinococcus multilocularis protein jagged 1 0.0174 0.0451 0.045
Brugia malayi enteropeptidase precursor 0.0263 0.0702 0.0701
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0049 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0241 0.0239
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Schistosoma mansoni microtubule-associated protein tau 0.1376 0.3844 0.3843
Schistosoma mansoni laminin gamma-3 chain 0.0174 0.0451 0.045
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0263 0.0702 0.0701
Schistosoma mansoni patched 1 0.1464 0.4093 0.4093
Plasmodium falciparum flap endonuclease 1 0.003 0.0045 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0217 0.0216
Echinococcus multilocularis cubilin 0.0205 0.0538 0.0537
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0205 0.0538 0.0538
Loa Loa (eye worm) trypsin family protein 0.0547 0.1504 0.1504
Onchocerca volvulus 0.1618 0.4528 0.766
Toxoplasma gondii hypothetical protein 0.0424 0.1157 0.1957
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0001 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Leishmania major hypothetical protein, conserved 0.2107 0.5907 0.5906
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0014 0.02
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0001 0.0022
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0001 0.0001
Echinococcus multilocularis Mastin 0.0547 0.1504 0.1503
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Schistosoma mansoni notch 0.0174 0.0451 0.045
Schistosoma mansoni hypothetical protein 0.0205 0.0538 0.0537
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Plasmodium vivax cysteine repeat modular protein 1, putative 0.2107 0.5907 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0231 0.0611 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0019 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0054 0.0054
Brugia malayi Kringle domain containing protein 0.2107 0.5907 0.5906
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0001 0.0001
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0702 0.0701
Onchocerca volvulus 0.1444 0.4037 0.6827
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0241 0.0239
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0094 0.0225 0.0225
Brugia malayi CUB domain containing protein 0.0205 0.0538 0.0537
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0001 0.0022
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0424 0.1157 0.1957
Echinococcus granulosus basement membrane specific heparan sulfate 0.0263 0.0702 0.0701
Echinococcus multilocularis fat cadherin tumor suppressor 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.2107 0.5907 0.5907
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Onchocerca volvulus 0.0205 0.0538 0.089
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Brugia malayi Dihydrofolate reductase 0.0094 0.0225 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0019 0.0018
Brugia malayi Cadherin domain containing protein 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.1444 0.4037 0.4037
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.3557 1 1
Onchocerca volvulus 0.0174 0.0451 0.0742
Schistosoma mansoni hypothetical protein 0.0174 0.0451 0.045
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0719 0.1989 0.1989
Schistosoma mansoni slit 0.0174 0.0451 0.045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.1504 0.1503
Mycobacterium ulcerans hypothetical protein 0.0547 0.1504 0.1504
Brugia malayi Trypsin family protein 0.0547 0.1504 0.1503
Schistosoma mansoni hypothetical protein 0.0475 0.13 0.1299
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0019 0.0018
Leishmania major hypothetical protein, conserved 0.0021 0.0019 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1464 0.4093 0.4093
Echinococcus granulosus dihydrofolate reductase 0.0094 0.0225 0.0224
Echinococcus multilocularis protein jagged 2 0.0174 0.0451 0.045
Brugia malayi SEA domain containing protein 0.1444 0.4037 0.4036
Echinococcus granulosus neurogenic locus notch protein 4 0.0174 0.0451 0.045
Onchocerca volvulus 0.0174 0.0451 0.0742
Echinococcus multilocularis neurogenic locus notch protein 4 0.0174 0.0451 0.045
Echinococcus multilocularis neurogenic locus protein delta 0.0174 0.0451 0.045
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Loa Loa (eye worm) CUB domain-containing protein 0.0205 0.0538 0.0538
Echinococcus granulosus protein jagged 1 0.0174 0.0451 0.045
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0001 0.0022
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0001 0.0001
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0325 0.0876 0.1482
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0263 0.0702 0.1169
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0001 0.0022
Loa Loa (eye worm) DPY-31 protein 0.0205 0.0538 0.0538
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0231 0.0611 0.061
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0001 0.0022
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.3557 1 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0702 0.0702
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0014 0.0012
Brugia malayi Muscle positioning protein 4 0.1618 0.4528 0.4527
Echinococcus granulosus cubilin 0.0205 0.0538 0.0537
Echinococcus granulosus low density lipoprotein receptor ldl 0.0263 0.0702 0.0701
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0049 0.0047
Brugia malayi CUB domain containing protein 0.0468 0.128 0.1279
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0014 0.0014
Brugia malayi Calcium binding EGF domain containing protein 0.0379 0.1029 0.1027
Onchocerca volvulus 0.0205 0.0538 0.089
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0701
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0019 0.0018
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1669 0.467 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0547 0.1504 0.1503
Schistosoma mansoni hypothetical protein 0.0263 0.0702 0.0701
Echinococcus granulosus cubilin 0.0205 0.0538 0.0537
Onchocerca volvulus Neurogenic locus notch homolog 0.0174 0.0451 0.0742
Loa Loa (eye worm) hypothetical protein 0.0424 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus granulosus low density lipoprotein receptor protein 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0019 0.0033
Toxoplasma gondii subtilisin SUB12 0.0424 0.1157 0.1957
Trichomonas vaginalis conserved hypothetical protein 0.011 0.027 0.0485
Schistosoma mansoni notch 0.0174 0.0451 0.045
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.3557 1 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0001 0.0001
Onchocerca volvulus 0.1444 0.4037 0.6827
Brugia malayi EGF-like domain containing protein 0.0174 0.0451 0.045
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0702 0.0701
Echinococcus granulosus Protein patched homolog 1 0.1464 0.4093 0.4093
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0205 0.0538 0.0537
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0205 0.0538 0.0538
Toxoplasma gondii microneme protein MIC17C 0.0424 0.1157 0.1957
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Echinococcus multilocularis enteropeptidase 0.0547 0.1504 0.1503
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0174 0.0451 0.0742
Echinococcus granulosus transmembrane protease serine 3 0.0547 0.1504 0.1503
Echinococcus multilocularis protein patched 0.1464 0.4093 0.4093
Brugia malayi Fibulin-1 precursor 0.0456 0.1247 0.1245
Echinococcus granulosus delta-like protein 1 0.0174 0.0451 0.045
Onchocerca volvulus 0.0547 0.1504 0.2529
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.3557 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.2107 0.5907 0.5906
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Echinococcus multilocularis GPCR, family 2 0.0031 0.0049 0.0047
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0547 0.1504 0.1503
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.1504 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.1464 0.4093 0.8753
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0719 0.1989 0.1988
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0263 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0263 0.0702 0.0701
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0205 0.0538 0.0537
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957
Loa Loa (eye worm) hypothetical protein 0.0174 0.0451 0.0451
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0049 0.0047
Brugia malayi PAN domain containing protein 0.0424 0.1157 0.1156
Brugia malayi Calcium binding EGF domain containing protein 0.0263 0.0702 0.0701
Loa Loa (eye worm) hypothetical protein 0.0547 0.1504 0.1504
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0001 0.0022
Toxoplasma gondii PAN domain-containing protein 0.0424 0.1157 0.1957

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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