Detailed information for compound 869074

Basic information

Technical information
  • TDR Targets ID: 869074
  • Name: 3-[(3,4-dimethylphenyl)amino]-4-(4-propan-2-y lphenyl)cyclobut-3-ene-1,2-dione
  • MW: 319.397 | Formula: C21H21NO2
  • H donors: 1 H acceptors: 2 LogP: 4.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=O)C(=C1c1ccc(cc1)C(C)C)Nc1ccc(c(c1)C)C
  • InChi: 1S/C21H21NO2/c1-12(2)15-6-8-16(9-7-15)18-19(21(24)20(18)23)22-17-10-5-13(3)14(4)11-17/h5-12,22H,1-4H3
  • InChiKey: XIYDSQUCICJJOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3,4-dimethylphenyl)amino]-4-(4-isopropylphenyl)cyclobut-3-ene-1,2-dione
  • 3-[(3,4-dimethylphenyl)amino]-4-(4-isopropylphenyl)cyclobut-3-ene-1,2-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0431 0.0454
Brugia malayi Cation transporter family protein 0.0012 0.0019 0.0021
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.2523 0.2508
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Schistosoma mansoni nuclear receptor 0.0041 0.0431 0.0454
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0222 0.2973
Brugia malayi steroid hormone receptor 0.0086 0.1086 0.1239
Onchocerca volvulus 0.0033 0.0327 0.0309
Onchocerca volvulus 0.0028 0.0245 0.0226
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0245 0.0279
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0222 0.5
Brugia malayi Cation transporter family protein 0.0012 0.0019 0.0021
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0222 0.013
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0136 0.1807 0.1906
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0379 0.0399
Loa Loa (eye worm) hypothetical protein 0.0045 0.0501 0.0571
Leishmania major cathepsin L-like protease 0.0033 0.0327 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.1086 0.1239
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0379 0.5081
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0115
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0567 0.0645
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.021
Echinococcus granulosus glycine receptor subunit beta 0.0058 0.0684 0.0721
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0119 0.0125
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0222 0.013
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0222 0.2143
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.1086 0.1239
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0379 0.0572
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0246 0.028
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0019 0.002
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Leishmania major DNA topoisomerase ii 0.0026 0.0222 0.0335
Schistosoma mansoni retinoic acid receptor RXR 0.0181 0.2463 0.2598
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0124 0.0187
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus multilocularis dna polymerase eta 0.0014 0.0047 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0743 0.0783
Loa Loa (eye worm) hypothetical protein 0.0469 0.662 0.755
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0238 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0746 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Echinococcus granulosus cathepsin L 0.0017 0.0094 0.0098
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0222 0.2973
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.0128
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0746 0.1126
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0222 0.2973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0469 0.662 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0113 0.0128
Echinococcus granulosus dna polymerase eta 0.0014 0.0047 0.0049
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0693 0.0731
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0019 0.0021
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0019 0.0021
Brugia malayi Pre-SET motif family protein 0.0089 0.1133 0.1291
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0222 0.2143
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0327 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0431 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0001 0.0002
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0222 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0767 0.0808
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0435 0.0459
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0124 0.1069
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0222 0.0335
Echinococcus granulosus lamin 0.0028 0.0245 0.0258
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0094 0.014
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0113 0.0118
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0019 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.1133 0.1195
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0019 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0113 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0379 0.0399
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0222 0.068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0168 0.0191
Schistosoma mansoni loxhd1 0.0059 0.0693 0.0731
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0767 0.1157
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0327 0.3896
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0327 0.0345
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0501 0.0528
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Schistosoma mansoni cathepsin s 0.0011 0.0005 0.0004
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0052 0.0603 0.0687
Trichomonas vaginalis esterase, putative 0.0037 0.0379 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus granulosus heat shock protein 0.0026 0.0222 0.0234
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0222 0.0335
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0693 0.6107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0017
Schistosoma mansoni rab6-interacting 0.0059 0.0693 0.0731
Schistosoma mansoni ap endonuclease 0.0019 0.0124 0.013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0693 0.0731
Onchocerca volvulus 0.0041 0.0431 0.0412
Plasmodium vivax vivapain-1 0.0017 0.0094 0.0789
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0222 0.5851
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0094 0.014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Schistosoma mansoni DNA polymerase eta 0.0014 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.0045 0.0501 0.0571
Loa Loa (eye worm) hypothetical protein 0.0059 0.0693 0.079
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.9478 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0113 0.0118
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.0128
Loa Loa (eye worm) hypothetical protein 0.0059 0.0693 0.079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0379 0.5081
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0019 0.0021
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0222 0.1928
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0168 0.0191
Echinococcus granulosus glycine receptor subunit beta 0.0058 0.0684 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0119 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.1086 0.1239
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Echinococcus multilocularis lamin dm0 0.0028 0.0245 0.0258
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0019 0.0021
Mycobacterium tuberculosis Conserved protein 0.0026 0.0222 0.068
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0431 0.0454
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0379 0.1163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0379 0.1163
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0431 0.0412
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0245 0.0278
Trichomonas vaginalis cdc25c, putative 0.0055 0.0635 0.0547
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0379 0.3321
Mycobacterium ulcerans beta-lactamase 0.0037 0.0379 0.5081
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.1133 0.1195
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0047 0.0071
Brugia malayi intermediate filament protein 0.0028 0.0245 0.0279
Schistosoma mansoni cpg binding protein 0.0028 0.0246 0.0259
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0635 0.0724
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0019 0.0021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0746 0.0786
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0418 0.0631
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0222 0.013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0379 0.1163
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.1086 0.1146
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.0018
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.057 0.0861
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0019 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0168 0.1677
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.1086 0.1239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.1086 0.1146
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0635 0.0724
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0222 0.0253
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0019 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0094 0.014
Onchocerca volvulus 0.0089 0.1133 0.1116
Trichomonas vaginalis CMGC family protein kinase 0.005 0.057 0.0481
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.1086 0.1146
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0164 0.2214 0.8545
Schistosoma mansoni lipoxygenase 0.0059 0.0693 0.0731
Loa Loa (eye worm) DR-78 0.0041 0.0431 0.0491
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0222 0.2195
Trichomonas vaginalis CMGC family protein kinase 0.005 0.057 0.0481
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0746 1
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Schistosoma mansoni hypothetical protein 0.0047 0.0518 0.0546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0501 0.0571
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0019 0.0021
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0435 0.0657
Schistosoma mansoni hypothetical protein 0.0037 0.0379 0.0399
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0019 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.057 0.0601
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0038 0.004
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0113 0.0118
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0113 0.0118
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0058 0.0684 0.0779
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0518 0.0591
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0094 0.0643
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0431 0.0454
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0327 0.0309
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0222 0.0203
Leishmania major hypothetical protein, conserved 0.0026 0.0222 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0327 0.0236
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0113 0.0118
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0431 0.0491
Brugia malayi follicle stimulating hormone receptor 0.0238 0.328 0.3741
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0222 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021
Echinococcus granulosus cpg binding protein 0.0029 0.0269 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0379 0.0432
Loa Loa (eye worm) hypothetical protein 0.0052 0.0603 0.0687
Echinococcus multilocularis cysteine protease 0.0033 0.0327 0.0345
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0035
Entamoeba histolytica cysteine protease, putative 0.0033 0.0327 0.3892
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0222 0.0335
Brugia malayi kinase, mitochondrial precursor 0.0469 0.662 0.755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.0128
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0222 0.0234
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0222 0.1928
Echinococcus multilocularis lamin 0.0028 0.0245 0.0258
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.1086 0.1146
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0222 0.2431
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0118
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0055 0.0635 0.067
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.057 0.2202
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0222 0.013
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0094 0.014
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0379 0.0399
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0746 0.0786
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0113 0.0128
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Brugia malayi N-terminal motif family protein 0.0185 0.2523 0.2876
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0379 0.0399
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.2214 0.3343
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0746 0.2879
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1682 0.254
Brugia malayi hypothetical protein 0.0037 0.0379 0.0431
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0279 0.0318
Schistosoma mansoni lamin 0.0028 0.0245 0.0258
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0019 0.002
Echinococcus multilocularis glycine receptor subunit beta 0.0058 0.0684 0.0721
Brugia malayi Doublecortin family protein 0.0059 0.0693 0.079
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0501 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0222 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.1086 0.1069
Loa Loa (eye worm) ctsf protein 0.0033 0.0327 0.0373
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0222 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.1133 0.4372
Brugia malayi nuclear receptor NHR-88 0.0041 0.0431 0.0491
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0222 0.0335
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0222 0.0857
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0693 0.0731
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0222 0.068
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0222 0.0203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.1086 0.1146
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0222 0.0857
Schistosoma mansoni serine/threonine protein kinase 0.005 0.057 0.0601
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0047 0.0071
Mycobacterium leprae Probable lipase LipE 0.0037 0.0379 1
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1289 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.1682 0.254
Schistosoma mansoni thyroid hormone receptor 0.0086 0.1086 0.1146
Leishmania major cathepsin L-like protease 0.0033 0.0327 0.0494
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0047 0.0049
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0164 0.222 0.2342
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0652 0.2516
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0222 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0327 0.0236
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0278
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0094 0.014
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0222 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.1086 0.1239
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.1086 0.1239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0501 0.0571
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Brugia malayi nuclear receptor NHR-67 0.0041 0.0431 0.0491
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0328 0.459 0.4843
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0115
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0124 0.1658
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.057 0.065
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0113 0.0118
Echinococcus granulosus geminin 0.0328 0.459 0.4843
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0431 0.0491
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Mycobacterium ulcerans hypothetical protein 0.0037 0.0379 0.5081
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0005 0.0005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0119 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0431 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0019 0.002
Onchocerca volvulus 0.0055 0.0635 0.0617
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0431 0.0491
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0767 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Brugia malayi nuclear receptor NHR-88 0.0086 0.1086 0.1239
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0094 0.0106
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0327 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0222 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0279 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0077 0.0115
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Plasmodium vivax vivapain-3 0.0017 0.0094 0.0789
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.057 0.0861
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0222 0.2431
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0019 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.1086 0.1239
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0435 0.0459
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0222 0.5
Onchocerca volvulus 0.0028 0.0246 0.0227
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0043
Brugia malayi Cytochrome P450 family protein 0.005 0.0567 0.0645
Loa Loa (eye worm) hypothetical protein 0.0089 0.1133 0.1291
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0222 0.0857
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0053
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0767 0.1157
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0379 0.0399
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0469 0.662 0.6985
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0222 0.1928
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0469 0.662 0.6985
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0222 0.068
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0327 0.0345
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.1086 0.1146
Onchocerca volvulus 0.0028 0.0245 0.0226
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0019 0.0021
Echinococcus multilocularis heat shock protein 0.0026 0.0222 0.0234
Schistosoma mansoni endoplasmin 0.0026 0.0222 0.0234
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.1086 0.1146
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0379 0.1163
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0431 0.0454
Giardia lamblia Pms1-like protein 0.0026 0.0222 0.2195
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0019 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0501 0.0528
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0222 0.068
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0113 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.005 0.057 0.0481
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1086 0.1239
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Mycobacterium tuberculosis Conserved protein 0.0037 0.0379 0.1163
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0635 0.0547
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.1086 0.1146
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.2214 0.3343
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0379 0.1163
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0222 0.2973
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0124 0.051
Leishmania major cathepsin L-like protease 0.0033 0.0327 0.0494
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0119 0.0125
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0222 0.0857
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0019 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.1086 0.1239
Schistosoma mansoni survival motor neuron protein 0.0047 0.0518 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0327 0.3892
Mycobacterium tuberculosis Conserved protein 0.0037 0.0379 0.1163
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0435 0.0657
Onchocerca volvulus 0.0033 0.0327 0.0309
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0124 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0005 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0017
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0094 0.014
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0124 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0418 0.0328
Echinococcus granulosus cathepsin l1 0.0022 0.0168 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.1086 0.1239
Brugia malayi Cathepsin L-like precursor 0.0022 0.0168 0.0191
Onchocerca volvulus 0.0037 0.0379 0.0361
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0222 0.0335
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0379 0.0288
Trichomonas vaginalis cdc25b, putative 0.0055 0.0635 0.0547
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.059 0.0622
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0094 0.0643
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0124 0.0187
Brugia malayi hypothetical protein 0.0059 0.0693 0.079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Schistosoma mansoni cpg binding protein 0.0029 0.0269 0.0283
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0435 0.0459
Echinococcus granulosus FTZ F1 alpha 0.0086 0.1086 0.1146
Plasmodium falciparum endoplasmin, putative 0.0026 0.0222 0.2143
Giardia lamblia DINP protein human, muc B family 0.002 0.0139 0.0341
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0005 0.0006
Brugia malayi CXXC zinc finger family protein 0.0028 0.0246 0.028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.057 0.0481
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.3146 0.3319
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0635 0.0547
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0431 0.0454
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0058 0.0684 0.0721
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0019 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0618 0.8768 1
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0435 0.0657
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0094 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.005 0.0574 0.0654
Brugia malayi ecdysone receptor 0.0041 0.0431 0.0491
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0047 0.0143
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0693 0.0731
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0327 0.3896
Brugia malayi ecdysteroid receptor 0.0086 0.1086 0.1239
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0222 0.0335
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0222 0.0335
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0019 0.002
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0418 0.5607
Onchocerca volvulus 0.0055 0.0635 0.0617
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0124 0.106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Echinococcus granulosus microtubule associated protein 2 0.0667 0.9478 1
Schistosoma mansoni pyruvate dehydrogenase 0.0443 0.6244 0.6587
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0094 0.0643
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0327 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0119 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0113 0.0118
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0055 0.0635 0.067
Loa Loa (eye worm) beta-lactamase 0.0037 0.0379 0.0432
Schistosoma mansoni heat shock protein 0.0026 0.0222 0.0234
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0693 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Echinococcus granulosus lamin dm0 0.0028 0.0245 0.0258
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0379 0.1163
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0327 0.0345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0228 0.3146 0.3587
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.1086 0.1239
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0327 0.0373
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Giardia lamblia Kinase, CMGC MAPK 0.005 0.057 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.1086 0.1146
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0222 0.068
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0119 0.0135
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0118
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0113 0.0128
Brugia malayi heat shock protein 90 0.0026 0.0222 0.0253
Brugia malayi Pre-SET motif family protein 0.0618 0.8768 1
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0222 0.0335
Echinococcus granulosus dna polymerase kappa 0.004 0.0418 0.0441
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0124 0.038
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0222 0.2973
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0379 0.0432
Onchocerca volvulus 0.0037 0.0379 0.0361
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0245 0.0257
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0222 0.0335
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0379 0.04
Onchocerca volvulus 0.0033 0.0327 0.0309
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0222 0.0335
Onchocerca volvulus 0.0055 0.0635 0.0617
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0431 0.0491
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0139 0.021
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0431 0.0491
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0418 0.0328
Leishmania major cathepsin L-like protease 0.0033 0.0327 0.0494
Leishmania major cathepsin L-like protease 0.0127 0.1682 0.254
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0222 0.013
Schistosoma mansoni hypothetical protein 0.0059 0.0693 0.0731
Onchocerca volvulus 0.0033 0.0327 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0635 0.0724
Leishmania major hypothetical protein, conserved 0.0037 0.0379 0.0572
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0019 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.1086 0.1069
Echinococcus multilocularis RUN 0.0059 0.0693 0.0731
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.3146 0.3319
Schistosoma mansoni thyroid hormone receptor 0.0086 0.1086 0.1146
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0635 0.0547
Brugia malayi hypothetical protein 0.0019 0.0113 0.0128
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0222 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0379 0.0288
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0431 0.0454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0019 0.0021
Schistosoma mansoni polycystin 1-related 0.0059 0.0693 0.0731
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.1086 0.1146
Echinococcus multilocularis glycine receptor subunit beta 0.0058 0.0684 0.0721
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0222 0.0234
Trypanosoma brucei protein kinase, putative 0.005 0.057 0.0861
Trichomonas vaginalis cdc25b, putative 0.0055 0.0635 0.0547
Onchocerca volvulus 0.0022 0.0168 0.0149
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0379 0.0288
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0019 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0222 0.2431
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0418 0.0631
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0222 0.2143
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0094 0.0643
Onchocerca volvulus 0.0059 0.0693 0.0676
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0222 0.068
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0222 0.5851
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0327 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.1086 0.1146
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0222 0.013
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0168 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.057 0.0601
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.1086 0.1146
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0435 0.0459
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0746 0.2289
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0574 0.0654
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0113 0.0118
Plasmodium vivax endoplasmin, putative 0.0026 0.0222 0.1928
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0113 0.0118
Schistosoma mansoni lipoxygenase 0.0164 0.222 0.2342
Entamoeba histolytica hypothetical protein 0.0037 0.0379 0.4609
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus multilocularis heat shock protein 90 0.0026 0.0222 0.0234
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0047 0.0053
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0435 0.0496
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0222 0.1928
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0222 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.1086 0.1239
Entamoeba histolytica hypothetical protein 0.0037 0.0379 0.4609
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0435 0.0657
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0059 0.0067
Onchocerca volvulus 0.0059 0.0693 0.0676
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0113 0.0118
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Brugia malayi hypothetical protein 0.0059 0.0693 0.079
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0635 0.8176
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0431 0.0491
Schistosoma mansoni pyruvate dehydrogenase 0.0469 0.662 0.6985
Brugia malayi polk-prov protein 0.003 0.0279 0.0318
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0019 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0435 0.0345
Echinococcus multilocularis geminin 0.0328 0.459 0.4843
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0019 0.002
Echinococcus multilocularis dna polymerase kappa 0.004 0.0418 0.0441
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0222 0.2973
Leishmania major DNA polymerase eta, putative 0.0014 0.0047 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1086 0.1146
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.2214 0.3343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0767 0.0808
Echinococcus multilocularis nAChR subunit 0.0012 0.0019 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1086 0.1146
Echinococcus granulosus mitogen activated protein kinase 0.005 0.057 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0767 0.0808
Loa Loa (eye worm) hypothetical protein 0.0045 0.0501 0.0571
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0746 1
Schistosoma mansoni cpg binding protein 0.0029 0.0269 0.0283
Brugia malayi beta-lactamase 0.0037 0.0379 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0094 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Echinococcus multilocularis expressed protein 0.0361 0.5055 0.5334
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.0128
Echinococcus granulosus dnaJ subfamily B 0.0395 0.5555 0.586
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.1133 0.1195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0767 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0635 0.0547
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0253
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0124 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0222 0.0335
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0327 0.0373
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0019 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0047 0.0049
Trypanosoma brucei developmentally regulated phosphoprotein 0.0469 0.662 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0327 0.0494
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0222 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0746 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.1133 0.1195
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.019 0.2591 1
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0113 0.0118
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0222 0.0253
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0164 0.222 0.2342
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0005
Trypanosoma brucei unspecified product 0.0033 0.0326 0.0492
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0222 0.2973
Entamoeba histolytica hypothetical protein 0.0019 0.0113 0.0911
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0469 0.662 0.6985
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0094 0.0098
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0418 0.0631
Leishmania major DNA polymerase kappa, putative 0.002 0.0139 0.021
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0222 0.0857
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0635 0.8176
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.0128
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0245 0.0257
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0222 0.0335
Mycobacterium ulcerans lipase LipD 0.0037 0.0379 0.5081
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0418 0.5607
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.0373
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0168 0.0191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1086 0.1239
Onchocerca volvulus 0.0033 0.0327 0.0309
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0181 0.2463 0.2598
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0047 0.0049
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.057 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0279 0.0421
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0703 1 1
Brugia malayi Cation transporter family protein 0.0058 0.0684 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.1086 0.1239
Schistosoma mansoni ap endonuclease 0.0019 0.0124 0.013
Onchocerca volvulus 0.0086 0.1086 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0094 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0379 0.0288
Brugia malayi nuclear hormone receptor 0.0086 0.1086 0.1239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.1086 0.1239
Brugia malayi hypothetical protein 0.0041 0.0431 0.0491
Echinococcus granulosus intermediate filament protein 0.0028 0.0245 0.0258
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0431 0.0454
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0693 0.0731
Loa Loa (eye worm) fibroinase 0.0033 0.0327 0.0373
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0245 0.0279
Brugia malayi conserved hypotetical protein 0.0041 0.0431 0.0491
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0222 0.5851
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0222 0.013
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.5555 0.586
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0431 0.0412
Schistosoma mansoni coup transcription factor 0.0086 0.1086 0.1146
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0222 0.0253
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0435 0.5395
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.1086 0.1239
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Plasmodium vivax vivapain-2 0.0033 0.0327 0.2861
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0327 0.0309
Plasmodium vivax SET domain protein, putative 0.0089 0.1133 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0222 0.068
Plasmodium vivax vivapain-2 0.0033 0.0327 0.2861
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi nuclear receptor RXR 0.0045 0.0501 0.0571
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0222 0.068
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0118
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Leishmania major cathepsin L-like protease 0.0127 0.1682 0.254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.1086 0.1239
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Schistosoma mansoni rab6-interacting 0.0059 0.0693 0.0731
Echinococcus granulosus cysteine protease 0.0017 0.0094 0.0098
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0431 0.0454
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Brugia malayi hypothetical protein 0.0045 0.0501 0.0571
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.9478 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0222 0.0253
Brugia malayi Cathepsin L-like precursor 0.0022 0.0168 0.0191
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0245 0.0278
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.1086 0.1146
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0326 0.0492
Leishmania major developmentally regulated phosphoprotein-like protein 0.0469 0.662 1
Echinococcus granulosus RUN 0.0059 0.0693 0.0731
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0245 0.0257
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Echinococcus multilocularis musashi 0.0028 0.0245 0.0258
Echinococcus granulosus heat shock protein 90 0.0026 0.0222 0.0234
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0435 0.0459
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0635 0.0547
Schistosoma mansoni zinc finger protein 0.0041 0.0431 0.0454
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0379 0.04
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0222 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0113 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0431 0.0454
Brugia malayi MAP kinase sur-1 0.005 0.057 0.065
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.0496
Schistosoma mansoni endoplasmin 0.0026 0.0222 0.0234
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0113 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1086 0.1239
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0222 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0435 0.0459
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0094 0.0643
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0222 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0431 0.0454
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0222 0.013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.059 0.0672
Onchocerca volvulus 0.0037 0.0379 0.0361
Schistosoma mansoni nuclear hormone receptor 0.0086 0.1086 0.1146
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0019 0.002
Onchocerca volvulus 0.0033 0.0327 0.0309
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.1086 0.1239
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0431 0.0454
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0222 0.2973
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.1086 0.1069
Brugia malayi hypothetical protein 0.0228 0.3146 0.3587
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.1086 0.1146
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0168 0.0075
Brugia malayi beta-lactamase family protein 0.0037 0.0379 0.0432
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0431 0.0454
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0222 0.2973
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0435 0.0459
Plasmodium vivax unspecified product 0.0017 0.0094 0.0789
Onchocerca volvulus 0.0041 0.0431 0.0412
Echinococcus granulosus expressed protein 0.0361 0.5055 0.5334
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0055 0.0635 0.067
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0418 0.0631
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.057 0.0861
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.1133 0.1195
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0435 0.6972
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0245 0.0257
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0418 0.0631
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0222 0.0335
Echinococcus granulosus nAChR subunit 0.0012 0.0019 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0222 0.068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.1086 0.1239
Plasmodium falciparum heat shock protein 90 0.0026 0.0222 0.2143
Loa Loa (eye worm) hypothetical protein 0.0086 0.1086 0.1239
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0767 0.1157
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0379 0.0288
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0431 0.0454
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0222 0.068
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0058 0.0684 0.0779
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi hypothetical protein 0.0019 0.0113 0.0128
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0501 0.0528
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0245 0.0257
Brugia malayi hypothetical protein 0.0045 0.0501 0.0571
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0222 0.0335
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0222 0.5851
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0047 0.0049
Loa Loa (eye worm) GABA receptor subunit 0.0052 0.0603 0.0687
Loa Loa (eye worm) hypothetical protein 0.0022 0.0168 0.0191
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0431 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.0128
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0379 1
Brugia malayi nuclear receptor RXR 0.0041 0.0431 0.0491
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0501 0.0571
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0327 0.0494
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0327 0.3896
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.059 0.0622
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0019 0.002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.1133 0.1195
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Brugia malayi beta-lactamase family protein 0.0037 0.0379 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0094 0.0106
Brugia malayi tailless protein 0.0041 0.0431 0.0491
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.1086 0.1146
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0435 0.0459
Toxoplasma gondii cathepsin CPL 0.0033 0.0327 0.1263
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0327 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0418 0.0631
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0253
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0118
Echinococcus multilocularis cathepsin L 0.0017 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.1086 0.1146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0684 0.0721
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.1133 0.1195
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.1086 0.1146
Echinococcus multilocularis thyroid hormone receptor alpha 0.0086 0.1086 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0113 0.0019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0693 0.079
Entamoeba histolytica hypothetical protein 0.0019 0.0113 0.0911
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1682 0.254
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.3257 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.1086 0.1146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0684 0.0721
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0435 0.0345
Schistosoma mansoni lamin 0.0028 0.0245 0.0258
Echinococcus granulosus cathepsin l1 0.0033 0.0327 0.0345
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0222 0.013
Loa Loa (eye worm) hypothetical protein 0.0185 0.2523 0.2876
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0327 0.0345
Toxoplasma gondii exonuclease III APE 0.0019 0.0124 0.0479
Brugia malayi Cathepsin L-like precursor 0.0033 0.0327 0.0373
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0222 0.068
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0379 0.1163
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0139 0.0426
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0245 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.1086 0.1239
Loa Loa (eye worm) hypothetical protein 0.0055 0.0635 0.0724
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0684 0.0721
Loa Loa (eye worm) endoplasmin 0.0026 0.0222 0.0253
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.328 0.3741
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.1086 0.1239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0124 0.013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0124 0.013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0746 0.0786
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0767 0.0874
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0168 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0086 0.1086 0.1239
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1522 0.2299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.1086 0.1239
Loa Loa (eye worm) hypothetical protein 0.0037 0.0379 0.0432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0124 0.0187
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0045 0.0501 0.0571
Trypanosoma cruzi cruzipain precursor, putative 0.0011 0.0005 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.1086 0.1146
Echinococcus multilocularis cpg binding protein 0.0029 0.0269 0.0283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.1086 0.1146
Schistosoma mansoni hypothetical protein 0.0395 0.5555 0.586
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.1077 0.1136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0431 0.0454
Brugia malayi Endoplasmin precursor 0.0026 0.0222 0.0253
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.0128
Loa Loa (eye worm) cysteine protease 0.0033 0.0327 0.0373
Schistosoma mansoni nuclear receptor 0.0041 0.0431 0.0454
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0693 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0119 0.0135
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.1086 0.1146
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0767 0.1157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0222 0.013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0501 0.0528
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.057 0.0861
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0379 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi nuclear hormone receptor 0.0041 0.0431 0.0491
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0379 0.0572
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0019 0.0021
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0118
Onchocerca volvulus 0.0033 0.0327 0.0309
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0684 0.0721
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0222 0.0335
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0094 0.0643
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0222 0.0335
Leishmania major cathepsin L-like protease 0.0033 0.0327 0.0494
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0058 0.0684 0.0721
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0019 0.0021
Entamoeba histolytica hypothetical protein 0.0037 0.0379 0.4609
Mycobacterium ulcerans putative regultory protein 0.0026 0.0222 0.2973
Schistosoma mansoni nAChR subunit 0.0012 0.0019 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0327 0.0236
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0052 0.059 0.0672
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0435 0.0345
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0019 0.0021
Echinococcus multilocularis cysteine protease 0.0033 0.0327 0.0345
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0055 0.0635 0.0617
Leishmania major cathepsin L-like protease 0.0127 0.1682 0.254
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Schistosoma mansoni hypothetical protein 0.01 0.1293 0.1364
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0245 0.0257
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0113 0.0019
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0019 0.0021
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0431 0.0491
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.057 0.0861
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.057 0.0861
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0119 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0327 0.0236
Toxoplasma gondii ABC1 family protein 0.0037 0.0379 0.1464
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0379 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0019 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0327 0.0345
Entamoeba histolytica cysteine protease, putative 0.0017 0.0094 0.0643
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0124 0.0141
Schistosoma mansoni pyruvate dehydrogenase 0.0443 0.6244 0.6587
Schistosoma mansoni intermediate filament proteins 0.0028 0.0245 0.0258
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0379 0.04
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0222 0.2973
Brugia malayi hypothetical protein 0.0041 0.0431 0.0491
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0222 0.013
Entamoeba histolytica hypothetical protein 0.0019 0.0113 0.0911
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0124 0.0187
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Onchocerca volvulus 0.0047 0.0518 0.05
Loa Loa (eye worm) hypothetical protein 0.0041 0.0431 0.0491
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0015 0.0016
Schistosoma mansoni heat shock protein 0.0026 0.0222 0.0234
Mycobacterium tuberculosis Conserved protein 0.0037 0.0379 0.1163
Brugia malayi cathepsin L-like precursor 0.0022 0.0168 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1682 0.254
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0327 0.3892
Trypanosoma brucei heat shock protein, putative 0.0026 0.0222 0.0335
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0635 0.8176
Leishmania major heat shock protein 83-1 0.0026 0.0222 0.0335
Entamoeba histolytica hypothetical protein 0.0037 0.0379 0.4609
Schistosoma mansoni hypothetical protein 0.0328 0.459 0.4843
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.057 0.0861
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0222 0.0335
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0222 0.2973
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0431 0.0491
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1682 0.254
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0019 0.0021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.