Detailed information for compound 870295

Basic information

Technical information
  • TDR Targets ID: 870295
  • Name: 6-methylbenzimidazolo[1,2-c]quinazoline
  • MW: 233.268 | Formula: C15H11N3
  • H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2ccccc2c2n1c1ccccc1n2
  • InChi: 1S/C15H11N3/c1-10-16-12-7-3-2-6-11(12)15-17-13-8-4-5-9-14(13)18(10)15/h2-9H,1H3
  • InChiKey: NQIDXSKSTZTFTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5677-78-1
  • ST5336720
  • BIM-0005950.P001
  • 6-Methyl-benzo[4,5]imidazo[1,2-c]quinazoline
  • BAS 00268526
  • 6-Methylbenzimidazo[1,2-c]quinazoline
  • SMR000103807
  • CBMicro_006039
  • ZINC00172854
  • EU-0041562
  • MLS000107843

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Echinococcus granulosus single minded 2 0.0038 0.0179 0.016
Toxoplasma gondii tubulin, putative 0.0057 0.0355 0.0317
Brugia malayi intermediate filament protein 0.0033 0.0129 0.009
Echinococcus multilocularis tubulin alpha 3 chain 0.084 0.7496 0.7491
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0039 0.0039
Leishmania major beta tubulin 0.1115 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1115 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0227 0.0208
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0489 0.0471
Echinococcus granulosus Tubulin beta 2C chain 0.1115 1 1
Schistosoma mansoni tubulin subunit delta 0.0288 0.2454 0.2454
Trypanosoma brucei alpha tubulin 0.084 0.7496 0.7496
Schistosoma mansoni ap endonuclease 0.0023 0.0039 0.0039
Echinococcus granulosus Tubulin alpha 1 chain 0.084 0.7496 0.7491
Trichomonas vaginalis tubulin epsilon chain, putative 0.1115 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0179 0.016
Leishmania major DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0019 0.0019
Trypanosoma brucei epsilon tubulin 0.0627 0.5552 0.5552
Leishmania major beta tubulin 0.1115 1 1
Leishmania major beta tubulin 0.1115 1 1
Schistosoma mansoni lamin 0.0033 0.0129 0.0129
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0137 0.0118
Schistosoma mansoni tubulin subunit epsilon 0.0685 0.6076 0.6076
Schistosoma mansoni hypothetical protein 0.0205 0.1698 0.1698
Toxoplasma gondii hypothetical protein 0.0059 0.0368 0.0331
Leishmania major beta tubulin 0.1115 1 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.008 0.008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0501 0.4398 0.4377
Plasmodium vivax tubulin gamma chain, putative 0.0685 0.6083 0.6068
Echinococcus multilocularis tubulin alpha 1C chain 0.084 0.7496 0.7491
Brugia malayi Tubulin alpha chain 0.084 0.7496 0.7486
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0044 0.0044
Loa Loa (eye worm) BEN-1 protein 0.1115 1 1
Loa Loa (eye worm) BEN-1 protein 0.1115 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0137 0.0118
Toxoplasma gondii beta-1 tubulin, putative 0.1115 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0553 0.4873 0.4863
Toxoplasma gondii alpha tubulin TUBA1 0.084 0.7496 0.7486
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0299 0.0299
Trypanosoma brucei beta tubulin 0.0627 0.5552 0.5552
Loa Loa (eye worm) tubulin gamma chain 0.0685 0.6083 0.6076
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Trypanosoma brucei tubulin delta chain 0.0647 0.5735 0.5735
Trypanosoma brucei zeta tubulin, putative 0.0889 0.7939 0.7939
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0553 0.4873 0.4853
Loa Loa (eye worm) tubulin alpha 2 0.0553 0.4873 0.4863
Loa Loa (eye worm) tubulin beta-1 chain 0.1115 1 1
Echinococcus multilocularis tubulin alpha chain 0.084 0.7496 0.7491
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3158 0.3158
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0084 0.0045
Schistosoma mansoni ap endonuclease 0.0023 0.0039 0.0039
Giardia lamblia DINP protein human, muc B family 0.0023 0.0044 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0084 0.0064
Echinococcus granulosus lamin dm0 0.0033 0.0129 0.0109
Echinococcus multilocularis lamin 0.0033 0.0129 0.0109
Loa Loa (eye worm) hypothetical protein 0.084 0.7496 0.7491
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0447 0.0447
Toxoplasma gondii beta-tubulin, putative 0.1115 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.1115 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.034 0.2929 0.2902
Trypanosoma brucei epsilon tubulin 0.0685 0.6076 0.6076
Trichomonas vaginalis tubulin alpha chain, putative 0.0627 0.5552 0.5535
Trichomonas vaginalis tubulin epsilon chain, putative 0.084 0.7496 0.7486
Leishmania major beta tubulin 0.1115 1 1
Leishmania major gamma-tubulin 0.0685 0.6083 0.6083
Schistosoma mansoni hypothetical protein 0.0205 0.1698 0.1698
Schistosoma mansoni lamin 0.0033 0.0129 0.0129
Echinococcus multilocularis tubulin alpha chain 0.084 0.7496 0.7491
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0137 0.0137
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0044 0.0025
Leishmania major beta tubulin 0.1115 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.084 0.7496 0.7491
Entamoeba histolytica tubulin gamma chain 0.0685 0.6083 0.6068
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.008 0.0061
Brugia malayi beta-tubulin, identical 0.1115 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0529 0.0511
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0179 0.0141
Echinococcus granulosus alpha tubulin 0.084 0.7496 0.7491
Echinococcus multilocularis tubulin alpha 0.0627 0.5552 0.5544
Echinococcus multilocularis Tubulin alpha 1 chain 0.084 0.7496 0.7491
Echinococcus granulosus dna polymerase eta 0.0023 0.0044 0.0025
Echinococcus multilocularis Tubulin alpha 1 chain 0.084 0.7496 0.7491
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Trypanosoma cruzi tubulin delta chain 0.0647 0.5735 0.5735
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0044 0.0044
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Brugia malayi tubulin alpha chain - mouse 0.084 0.7496 0.7486
Entamoeba histolytica tubulin family protein 0.1115 1 1
Echinococcus multilocularis tumor protein p63 0.0408 0.3553 0.3541
Plasmodium falciparum alpha tubulin 1 0.084 0.7496 0.7486
Giardia lamblia Beta tubulin 0.1115 1 1
Brugia malayi Tubulin alpha-2 chain 0.084 0.7496 0.7486
Loa Loa (eye worm) RNA binding protein 0.0076 0.0529 0.0511
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0227 0.0208
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0019 0.0019
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0179 0.0581
Trypanosoma brucei zeta tubulin 0.0889 0.7939 0.7939
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0529 0.0529
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Entamoeba histolytica hypothetical protein 0.0076 0.0528 0.0491
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0025 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0299 0.0299
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0288 0.2454 1
Brugia malayi Bromodomain containing protein 0.0046 0.0253 0.0216
Schistosoma mansoni tubulin subunit alpha 0.0288 0.2454 0.2454
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.008 0.0061
Trichomonas vaginalis tubulin, putative 0.1115 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0288 0.2454 0.2425
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0084 0.0065
Trypanosoma brucei tubulin gamma chain 0.0685 0.6083 0.6083
Plasmodium vivax tubulin alpha chain, putative 0.084 0.7496 0.7486
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0039 0.0039
Echinococcus multilocularis lamin dm0 0.0033 0.0129 0.0109
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0084 0.0084
Trypanosoma brucei alpha tubulin 0.084 0.7496 0.7496
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0137 0.0408
Trichomonas vaginalis tubulin alpha chain, putative 0.034 0.2929 0.2902
Trypanosoma brucei alpha tubulin 0.084 0.7496 0.7496
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.2454 0.2425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0129 0.0109
Leishmania major cathepsin L-like protease 0.0068 0.0447 0.0447
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Mycobacterium leprae cell division protein FtsZ 0.0288 0.2454 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.2067 0.2052
Leishmania major cathepsin L-like protease 0.0068 0.0447 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Echinococcus multilocularis Tubulin beta 2C chain 0.1115 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0529 0.0529
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0529 0.0492
Echinococcus granulosus tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0137 0.0118
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0137 0.0099
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0044 0.0005
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.084 0.7496 0.7486
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0137 0.0137
Leishmania major beta tubulin 0.1115 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1115 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0044 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Leishmania major beta tubulin 0.1115 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0685 0.6076 0.6076
Echinococcus granulosus tubulin alpha chain 0.084 0.7496 0.7491
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0044 0.0005
Echinococcus multilocularis beta tubulin 0.1115 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Echinococcus granulosus geminin 0.0205 0.1698 0.1682
Schistosoma mansoni bromodomain containing protein 0.0076 0.0528 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Leishmania major beta tubulin 0.1115 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.034 0.2929 0.2902
Giardia lamblia Gamma tubulin 0.0685 0.6083 0.6068
Trichomonas vaginalis tubulin epsilon chain, putative 0.0288 0.2454 0.2425
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0647 0.5735 0.5718
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0394 0.0394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Plasmodium vivax delta tubulin, putative 0.0288 0.2454 0.2425
Echinococcus granulosus tubulin epsilon chain 0.0685 0.6076 0.6068
Echinococcus multilocularis Tubulin beta 2C chain 0.1115 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0528 0.0509
Plasmodium falciparum tubulin epsilon chain, putative 0.0685 0.6076 0.606
Echinococcus granulosus tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus multilocularis tubulin beta 1 chain 0.1115 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Echinococcus multilocularis hypothetical protein 0.084 0.7496 0.7491
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0044 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1406 0.1406
Brugia malayi isocitrate dehydrogenase 0.0034 0.0137 0.0099
Echinococcus multilocularis tubulin delta chain 0.0288 0.2454 0.244
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Schistosoma mansoni alpha tubulin 0.084 0.7496 0.7496
Schistosoma mansoni single-minded 0.0051 0.0301 0.0301
Trichomonas vaginalis tubulin alpha chain, putative 0.1115 1 1
Trypanosoma cruzi zeta tubulin, putative 0.0889 0.7939 0.7939
Trypanosoma brucei epsilon tubulin 0.0685 0.6076 0.6076
Treponema pallidum cell division protein FtsZ 0.0288 0.2454 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0039 0.0039
Onchocerca volvulus 0.006 0.0376 0.0884
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0026 0.0007
Trichomonas vaginalis tubulin alpha chain, putative 0.034 0.2929 0.2902
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0084 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0137 0.0118
Loa Loa (eye worm) tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus granulosus tubulin subunit beta 0.1115 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0685 0.6083 0.6076
Echinococcus granulosus tubulin alpha 0.0627 0.5552 0.5544
Echinococcus multilocularis tubulin alpha 3 chain 0.084 0.7496 0.7491
Trypanosoma brucei beta tubulin 0.1115 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0402 0.0402
Trypanosoma brucei beta tubulin 0.1115 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.084 0.7496 0.7486
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Echinococcus granulosus Tubulin beta 2C chain 0.1115 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0447 0.0447
Loa Loa (eye worm) alpha-tubulin 0.084 0.7496 0.7491
Loa Loa (eye worm) tubulin alpha 2 0.0213 0.1775 0.1759
Echinococcus multilocularis tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus granulosus intermediate filament protein 0.0033 0.0129 0.0109
Plasmodium falciparum alpha tubulin 2 0.084 0.7496 0.7486
Trichomonas vaginalis tubulin epsilon chain, putative 0.084 0.7496 0.7486
Echinococcus multilocularis tubulin epsilon chain 0.0685 0.6076 0.6068
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0084 0.0084
Echinococcus granulosus tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0528 0.0509
Loa Loa (eye worm) alpha-tubulin 0.084 0.7496 0.7491
Schistosoma mansoni tubulin subunit alpha 0.084 0.7496 0.7496
Trypanosoma cruzi beta tubulin, putative 0.1115 1 1
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Echinococcus multilocularis zinc finger protein 0.0024 0.0047 0.0028
Plasmodium falciparum tubulin beta chain 0.1115 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0085 0.061 0.0592
Brugia malayi TAR-binding protein 0.0076 0.0529 0.0492
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0025
Schistosoma mansoni DNA polymerase eta 0.0023 0.0044 0.0044
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0345 0.2978 0.2951
Brugia malayi Tubulin gamma chain 0.0685 0.6083 0.6068
Plasmodium falciparum tubulin gamma chain 0.0685 0.6083 0.6068
Echinococcus multilocularis tubulin alpha chain 0.084 0.7496 0.7491
Echinococcus multilocularis musashi 0.0033 0.0129 0.0109
Echinococcus multilocularis geminin 0.0205 0.1698 0.1682
Onchocerca volvulus 0.034 0.2929 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0044 0.0025
Onchocerca volvulus 0.0038 0.0179 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Brugia malayi Bromodomain containing protein 0.0091 0.0658 0.0621
Brugia malayi hypothetical protein 0.0173 0.1407 0.1374
Trypanosoma cruzi epsilon tubulin, putative 0.0685 0.6076 0.6076
Echinococcus granulosus tubulin alpha chain 0.084 0.7496 0.7491
Loa Loa (eye worm) tubulin beta chain 0.0288 0.2454 0.244
Brugia malayi hypoxia-induced factor 1 0.0159 0.1285 0.1251
Echinococcus granulosus tubulin subunit TubB 0.084 0.7496 0.7491
Leishmania major zeta tubulin, putative 0.0889 0.7939 0.7939
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3158 0.3158
Trypanosoma brucei beta tubulin 0.1115 1 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0529 0.0511
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0299 0.0299
Loa Loa (eye worm) tubulin alpha chain 0.084 0.7496 0.7491
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Trichomonas vaginalis tubulin gamma chain, putative 0.0685 0.6083 0.6068
Echinococcus multilocularis tubulin alpha 1C chain 0.084 0.7496 0.7491
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0129 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0039 0.0039
Echinococcus granulosus beta tubulin 0.1115 1 1
Leishmania major epsilon tubulin, putative 0.0685 0.6076 0.6076
Loa Loa (eye worm) hypothetical protein 0.0049 0.028 0.0261
Echinococcus granulosus tumor protein p63 0.0408 0.3553 0.3541
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.1285 0.1268
Trypanosoma cruzi tubulin delta chain 0.0647 0.5735 0.5735
Trypanosoma cruzi alpha tubulin, putative 0.084 0.7496 0.7496
Trypanosoma cruzi zeta tubulin, putative 0.0889 0.7939 0.7939
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0137 0.0099
Schistosoma mansoni intermediate filament proteins 0.0033 0.0129 0.0129
Brugia malayi PHD-finger family protein 0.003 0.0106 0.0067
Echinococcus granulosus tubulin delta chain 0.0288 0.2454 0.244
Echinococcus granulosus Tubulin beta 2C chain 0.1115 1 1
Brugia malayi PAS domain containing protein 0.0051 0.0301 0.0263
Brugia malayi Cell division protein ftsZ 0.0288 0.2454 0.2425
Trypanosoma brucei alpha tubulin, putative 0.034 0.2929 0.2929
Trichomonas vaginalis tubulin, putative 0.034 0.2929 0.2902
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0044 0.0022
Loa Loa (eye worm) tubulin alpha-3 chain 0.0501 0.4398 0.4387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Leishmania major beta tubulin 0.1115 1 1
Brugia malayi Tubulin beta chain 0.0288 0.2454 0.2425
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Toxoplasma gondii beta tubulin 0.1115 1 1
Schistosoma mansoni tubulin subunit alpha 0.084 0.7496 0.7496
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0447 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0137 0.0118
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0316 0.0316
Plasmodium vivax tubulin alpha chain, putative 0.084 0.7496 0.7486
Leishmania major beta tubulin 0.1115 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Trichomonas vaginalis tubulin epsilon chain, putative 0.1115 1 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0288 0.2454 0.2425
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0104
Brugia malayi alpha-tubulin 0.084 0.7496 0.7486
Entamoeba histolytica hypothetical protein 0.0076 0.0528 0.0491
Brugia malayi hypothetical protein 0.0028 0.0084 0.0045
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0044 0.0005
Giardia lamblia Beta tubulin 0.1115 1 1
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0447 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0529 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0529 0.0529
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0489 0.0471
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0044 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0039 0.0019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0137 0.0099
Echinococcus granulosus tar DNA binding protein 0.0076 0.0529 0.0511
Echinococcus granulosus Tubulin beta 2C chain 0.1115 1 1
Giardia lamblia Beta tubulin 0.1115 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0137 0.0118
Leishmania major beta tubulin 0.1115 1 1
Echinococcus granulosus beta tubulin 0.1115 1 1
Brugia malayi Tubulin alpha chain 0.0288 0.2454 0.2425
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.034 0.2929 0.2902
Leishmania major beta tubulin 0.1115 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0627 0.5552 0.5535
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0137 0.0137
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0529 0.0511
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1406 0.1406
Loa Loa (eye worm) tubulin beta-2A chain 0.1115 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0137 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0137 0.0099
Loa Loa (eye worm) hypothetical protein 0.0173 0.1407 0.139
Leishmania major beta tubulin 0.1115 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0039 0.0019
Loa Loa (eye worm) hypothetical protein 0.0501 0.4398 0.4387
Echinococcus granulosus tubulin alpha 3 chain 0.084 0.7496 0.7491
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1115 1 1
Brugia malayi RNA binding protein 0.0076 0.0529 0.0492
Echinococcus granulosus tubulin alpha 1C chain 0.084 0.7496 0.7491
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.2454 0.2425
Giardia lamblia Alpha-tubulin 0.084 0.7496 0.7486
Leishmania major delta tubulin, putative 0.0647 0.5735 0.5735
Trichomonas vaginalis tubulin gamma chain, putative 0.1115 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0553 0.4873 0.4863
Loa Loa (eye worm) beta-tubulin 0.1115 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3158 0.3158
Leishmania major beta tubulin 0.1115 1 1
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1406 0.1406
Brugia malayi follicle stimulating hormone receptor 0.0245 0.2067 0.2037
Echinococcus granulosus lamin 0.0033 0.0129 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0129 0.0109
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Schistosoma mansoni alpha tubulin 0.084 0.7496 0.7496
Loa Loa (eye worm) hypothetical protein 0.0046 0.0254 0.0235
Brugia malayi Tubulin beta chain 0.034 0.2929 0.2902
Toxoplasma gondii alpha-tubulin I, putative 0.084 0.7496 0.7486
Echinococcus granulosus tubulin beta 1 chain 0.1115 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.084 0.7496 0.7491
Echinococcus granulosus Tubulin beta 2C chain 0.1115 1 1
Entamoeba histolytica tubulin alpha chain, putative 0.084 0.7496 0.7486
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Echinococcus multilocularis tubulin alpha chain 0.084 0.7496 0.7491
Leishmania major beta tubulin 0.1115 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0059 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0528 0.0528
Entamoeba histolytica tubulin family protein 0.1115 1 1
Schistosoma mansoni tubulin subunit gamma 0.0685 0.6083 0.6083
Trypanosoma brucei beta tubulin 0.1115 1 1
Giardia lamblia Delta tubulin 0.0288 0.2454 0.2425
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0044 0.0025
Plasmodium vivax tubulin epsilon chain, putative 0.0685 0.6076 0.606
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0044 0.0005
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0044 0.0022
Echinococcus multilocularis tubulin subunit beta 0.1115 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Schistosoma mansoni alpha tubulin 0.084 0.7496 0.7496
Trypanosoma brucei unspecified product 0.0023 0.0044 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0044 0.0044
Loa Loa (eye worm) tubulin beta-4 chain 0.1115 1 1
Trichomonas vaginalis tubulin, putative 0.034 0.2929 0.2902
Trypanosoma brucei alpha tubulin 0.084 0.7496 0.7496
Entamoeba histolytica hypothetical protein 0.0076 0.0528 0.0491
Brugia malayi hypothetical protein 0.0076 0.0528 0.0491
Leishmania major beta tubulin 0.1115 1 1
Trichomonas vaginalis tubulin, putative 0.0346 0.2986 0.2958
Loa Loa (eye worm) tubulin beta chain 0.1115 1 1
Giardia lamblia Alpha-tubulin 0.084 0.7496 0.7486
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Mycobacterium ulcerans cell division protein FtsZ 0.0288 0.2454 1
Brugia malayi tubulin alpha-2 chain 0.084 0.7496 0.7486
Trichomonas vaginalis tubulin gamma chain, putative 0.0685 0.6076 0.606
Trypanosoma cruzi tubulin gamma chain 0.0685 0.6083 0.6083
Echinococcus multilocularis dna polymerase eta 0.0023 0.0044 0.0025
Echinococcus multilocularis Tubulin alpha 1 chain 0.084 0.7496 0.7491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0447 0.0447
Brugia malayi Cytochrome P450 family protein 0.0028 0.0084 0.0046
Leishmania major hypothetical protein, conserved 0.0028 0.0084 0.0084
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0044 0.0025
Brugia malayi Tubulin alpha-2 chain 0.084 0.7496 0.7486
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0529 0.0529
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Echinococcus granulosus tubulin alpha 3 chain 0.084 0.7496 0.7491
Echinococcus granulosus tubulin alpha 1C chain 0.084 0.7496 0.7491
Schistosoma mansoni tubulin subunit beta 0.0288 0.2454 0.2454
Loa Loa (eye worm) hypothetical protein 0.006 0.0376 0.0358
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1584 0.6395
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0044
Schistosoma mansoni zinc finger protein 0.0024 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0076 0.0528 0.0528
Echinococcus multilocularis tubulin subunit TubB 0.084 0.7496 0.7491
Schistosoma mansoni tubulin subunit alpha 0.084 0.7496 0.7496
Leishmania major DNA polymerase eta, putative 0.0023 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0052 0.0301 0.0282
Leishmania major cathepsin L-like protease 0.0068 0.0447 0.0447
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0044 0.0044
Echinococcus granulosus Tubulin alpha 1 chain 0.084 0.7496 0.7491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0019 0.0019
Echinococcus granulosus zinc finger protein 0.0024 0.0047 0.0028
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0137 0.0137
Plasmodium vivax tubulin beta chain, putative 0.1115 1 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0376 0.0376
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0044 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0044 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0039 0.0019
Echinococcus multilocularis Tubulin beta 2C chain 0.1115 1 1
Plasmodium falciparum tubulin delta chain, putative 0.0288 0.2454 0.2425
Mycobacterium tuberculosis Cell division protein FtsZ 0.0288 0.2454 1
Trichomonas vaginalis tubulin beta chain, putative 0.084 0.7496 0.7486
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0044 0.0044
Echinococcus multilocularis tubulin gamma 1 chain 0.0685 0.6083 0.6076
Loa Loa (eye worm) hypothetical protein 0.0553 0.4873 0.4863
Leishmania major beta tubulin 0.1115 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0129 0.0109
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0299 0.0299
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0137 0.0137
Echinococcus multilocularis beta tubulin 0.1115 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.084 0.7496 0.7491
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0044 0.0044
Echinococcus multilocularis Tubulin beta 2C chain 0.1115 1 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.1584 0.6395
Giardia lamblia Epsilon tubulin 0.0345 0.2978 0.2951
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0084 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0084 0.0045
Schistosoma mansoni tubulin subunit beta 0.1115 1 1
Entamoeba histolytica hypothetical protein 0.0076 0.0528 0.0491
Echinococcus multilocularis peroxisome assembly protein 26 0.084 0.7496 0.7491
Leishmania major alpha tubulin 0.084 0.7496 0.7496
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3158 0.3158
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0137 0.0099

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 26.8545 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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