Detailed information for compound 88098

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.555 | Formula: C28H29FN4
  • H donors: 1 H acceptors: 1 LogP: 6.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1c(NC2CCN(CC2)C/C=C/c2ccccc2)nc2c1cccc2
  • InChi: 1S/C28H29FN4/c29-24-14-12-23(13-15-24)21-33-27-11-5-4-10-26(27)31-28(33)30-25-16-19-32(20-17-25)18-6-9-22-7-2-1-3-8-22/h1-15,25H,16-21H2,(H,30,31)/b9-6+
  • InChiKey: WVOZXGZNQPYOQX-RMKNXTFCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.2262
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0106 0.4547
Leishmania major cytochrome p450-like protein 0.0018 0.0053 0.011
Entamoeba histolytica hypothetical protein 0.0019 0.0063 0.0541
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0091 0.08
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0156 0.0537
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0106 0.4547
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0161 0.7495
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0175 0.0154
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0161 0.0327
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.4291 0.4279
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0106 0.064
Brugia malayi glutathione reductase 0.0037 0.0172 0.0593
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0357 0.1166
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0106 0.064
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Trypanosoma brucei trypanothione reductase 0.0037 0.0172 0.0523
Brugia malayi beta-lactamase family protein 0.0035 0.0161 0.0554
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0468 0.3374
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0172 0.114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0091 0.1032
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0469 0.2902 0.2887
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0106 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0193 0.0595
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0106 0.1123
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0106 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0053 0.0239
Echinococcus granulosus nibrin 0.0019 0.0063 0.0099
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0468 0.3374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0193
Mycobacterium ulcerans hypothetical protein 0.0035 0.0161 0.2075
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0193 0.9196
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0063 0.0218
Schistosoma mansoni cpg binding protein 0.0029 0.0122 0.0237
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0161 0.0554
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0053 0.0469
Loa Loa (eye worm) hypothetical protein 0.0149 0.0883 0.2957
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0357 0.1166
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0195
Schistosoma mansoni hypothetical protein 0.0073 0.0405 0.0899
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0053 0.011
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0182 0.0161
Loa Loa (eye worm) hypothetical protein 0.0465 0.2875 0.9903
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0193 0.2993
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0063 0.0376
Plasmodium falciparum glutathione reductase 0.0037 0.0172 1
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0694 0.1577
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0035 0.0732
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0161 0.1056
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0164 0.0976 0.8529
Leishmania major cytochrome p450-like protein 0.0026 0.0108 0.0301
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0053 0.0469
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0035 0.0732
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0063 0.4974
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0021 0.0073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0325 0.0712
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0108 0.0301
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0694 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.1032
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0208 0.0187
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0156 0.0316
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0053 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.2262
Loa Loa (eye worm) hypothetical protein 0.0098 0.0562 0.1838
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0053 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0259 0.0557
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0053 0.0471
Schistosoma mansoni pyruvate dehydrogenase 0.0469 0.2902 0.6747
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0161 0.1056
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0108 0.0301
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0161 0.0439
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0091 0.1059
Onchocerca volvulus 0.0029 0.0122 0.1933
Onchocerca volvulus 0.0024 0.0091 0.1395
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0694 0.6011
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0161 0.1056
Loa Loa (eye worm) glutathione reductase 0.0037 0.0172 0.0478
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0063
Brugia malayi cytochrome P450 0.0018 0.0053 0.0182
Entamoeba histolytica hypothetical protein 0.0074 0.0408 0.7073
Schistosoma mansoni alpha-glucosidase 0.0154 0.0916 0.2096
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0193 0.9196
Brugia malayi Muscleblind-like protein 0.0149 0.0883 0.3042
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0193 0.9196
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.1032
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0106 0.0085
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0053 0.0239
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0193 0.055
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Brugia malayi Cytochrome P450 family protein 0.0026 0.0108 0.0372
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0091 0.1059
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0106 0.0294
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0106 0.4547
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Trichomonas vaginalis esterase, putative 0.0035 0.0161 0.7495
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0063 0.0099
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0106 0.064
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0106 0.0294
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0063 0.0099
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.019 0.1141 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0208 1
Schistosoma mansoni hypothetical protein 0.0041 0.0198 0.0414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0106 0.0294
Echinococcus multilocularis expressed conserved protein 0.0092 0.0524 0.0504
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0172 0.0523
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0828 0.0809
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0357 0.1166
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0053 0.0239
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0106 0.0757
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0106 0.1655
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0106 0.4547
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0106 0.0294
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0035 0.0445
Schistosoma mansoni topbp1 0.0019 0.0063 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0091 0.0241
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0035 0.0047
Brugia malayi beta-lactamase family protein 0.0035 0.0161 0.0554
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0053 0.0469
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0526 0.3818
Schistosoma mansoni hypothetical protein 0.0041 0.0198 0.0414
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0106 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0122 0.0305
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0193 0.0172
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0053 0.0469
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0161 0.0327
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0106 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0357 0.1124
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0063 0.0376
Schistosoma mansoni endoplasmin 0.0026 0.0106 0.0198
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0035 0.0047
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0106 0.1259
Entamoeba histolytica hypothetical protein 0.0074 0.0408 0.7073
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0106 0.0757
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0106 0.0248
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0053 0.0239
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0091 0.0241
Echinococcus granulosus muscleblind protein 0.0149 0.0883 0.2018
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0208 0.0436
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0357 0.0787
Echinococcus granulosus GPCR family 2 0.0034 0.0156 0.0316
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0106 0.562
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0193 0.9196
Echinococcus multilocularis protein patched 0.0042 0.0208 0.0187
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0108 0.1289
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0106 0.1655
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0053 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0063
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0053 0.011
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0053 0.0282
Schistosoma mansoni cpg binding protein 0.003 0.0133 0.0261
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0193 0.0664
Plasmodium falciparum heat shock protein 90 0.0026 0.0106 0.562
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0053 0.0469
Brugia malayi kinase, mitochondrial precursor 0.0469 0.2902 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0035 0.0732
Brugia malayi CHE-14 protein 0.0042 0.0208 0.0715
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Schistosoma mansoni hypothetical protein 0.0095 0.054 0.1214
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0106 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0193 0.9196
Trypanosoma brucei developmentally regulated phosphoprotein 0.0469 0.2902 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0259 0.0893
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0053 0.0469
Schistosoma mansoni DNA ligase IV 0.0019 0.0063 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0259 0.0557
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0156 0.0537
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0106 0.1123
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0106 1
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.252 0.2504
Brugia malayi Endoplasmin precursor 0.0026 0.0106 0.0365
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Schistosoma mansoni hypothetical protein 0.0408 0.252 0.5851
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0106 0.1259
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0106 0.4547
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0694 0.0675
Entamoeba histolytica hypothetical protein 0.0074 0.0408 0.7073
Schistosoma mansoni cytochrome P450 0.0018 0.0053 0.0074
Onchocerca volvulus 0.0095 0.054 0.9032
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0208 0.0436
Leishmania major hypothetical protein, conserved 0.0035 0.0161 0.0485
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0035 0.0047
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0468 0.3374
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0694 0.1577
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0053 0.2102
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0106 0.1259
Schistosoma mansoni survival motor neuron protein 0.0095 0.054 0.1214
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0313
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0063 0.0042
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0106 0.064
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0828 0.189
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0106 0.0365
Leishmania major developmentally regulated phosphoprotein-like protein 0.0469 0.2902 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0193
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0106 0.1123
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0063 0.2796
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0106 0.562
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0106 0.064
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0035 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0694 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0053 0.0239
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Onchocerca volvulus 0.0035 0.0161 0.259
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0053 0.0239
Schistosoma mansoni hypothetical protein 0.0074 0.0408 0.0905
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0053 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0161 0.9262
Plasmodium falciparum thioredoxin reductase 0.0037 0.0172 1
Schistosoma mansoni heat shock protein 0.0026 0.0106 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0316
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0106 0.1349
Loa Loa (eye worm) hypothetical protein 0.0107 0.062 0.204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0208 0.0602
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0091 0.08
Toxoplasma gondii ABC1 family protein 0.0035 0.0161 0.1247
Brugia malayi hypothetical protein 0.0465 0.2875 0.9904
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0469 0.2902 0.6747
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0694 0.2337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1074 0.1055
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0328 0.1021
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0053 0.011
Onchocerca volvulus 0.0035 0.0161 0.259
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0035 0.0732
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0562 0.1936
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0106 0.0757
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0063 0.2262
Loa Loa (eye worm) hypothetical protein 0.0052 0.0268 0.0811
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0063 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0108 0.0255
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0053 0.0469
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0053 0.0469
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0259 0.0783
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0106 0.562
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0106 0.064
Brugia malayi beta-lactamase 0.0035 0.0161 0.0554
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.0976 0.3315
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0161 0.2283
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0106 0.064
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0469 0.2902 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0161 0.1056
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0468 0.3374
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0063 0.0146
Plasmodium vivax glutathione reductase, putative 0.0037 0.0172 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0357 0.6114
Schistosoma mansoni cpg binding protein 0.003 0.0133 0.0261
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0106 0.4547
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.2262
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0053 0.0239
Brugia malayi DKFZp564C0469 protein 0.0019 0.0063 0.0218
Loa Loa (eye worm) endoplasmin 0.0026 0.0106 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.1032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0405 0.1291
Echinococcus granulosus heat shock protein 0.0026 0.0106 0.0198
Brugia malayi hypothetical protein 0.0019 0.0063 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0161 0.7495
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0019 0.0063 0.0223
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0156 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0053 0.0239
Brugia malayi Thioredoxin reductase 0.0037 0.0172 0.0593
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0106 0.0365
Mycobacterium ulcerans beta-lactamase 0.0035 0.0161 0.2075
Schistosoma mansoni endoplasmin 0.0026 0.0106 0.0198
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0193 0.9196
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0106 0.0198
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0053 0.0469
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.2762 0.2747
Schistosoma mansoni pyruvate dehydrogenase 0.0443 0.2738 0.6361
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0694 0.5087
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0468 0.876
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0193 0.2993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.2875 0.6682
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0063
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0053 0.0239
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0193 0.153
Onchocerca volvulus 0.0019 0.0063 0.093
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0053 0.0239
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0161 0.0485
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0161 0.7495
Mycobacterium leprae Probable lipase LipE 0.0035 0.0161 0.2283
Plasmodium vivax endoplasmin, putative 0.0026 0.0106 0.562
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0106 0.064
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0106 0.1349
Echinococcus granulosus dnaJ subfamily B 0.0408 0.252 0.5851
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0053 0.3741
Loa Loa (eye worm) hypothetical protein 0.0469 0.2902 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0106 0.0294
Brugia malayi Cytochrome P450 family protein 0.0026 0.0108 0.0372
Echinococcus multilocularis protein dispatched 1 0.0048 0.0245 0.0224
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0106 0.4547
Schistosoma mansoni alpha glucosidase 0.004 0.0193 0.0401
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0328 0.0718
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0193 0.0595
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0883 0.0864
Treponema pallidum DNA ligase (lig) 0.0019 0.0063 0.4974
Brugia malayi hypothetical protein 0.0019 0.0063 0.0218
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0106 0.0198
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0562 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0328 0.0718
Schistosoma mansoni hypothetical protein 0.0041 0.0198 0.0414
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0106 1
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0316
Leishmania major hypothetical protein, conserved 0.0026 0.0106 0.0294
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0182 0.0376
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0035 0.0732
Leishmania major DNA topoisomerase ii 0.0026 0.0106 0.0294
Schistosoma mansoni heat shock protein 0.0026 0.0106 0.0198
Loa Loa (eye worm) hypothetical protein 0.0149 0.0883 0.2957
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0161 0.0485
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0063 0.2262
Toxoplasma gondii thioredoxin reductase 0.0037 0.0172 0.1347
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.1074 0.2465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0259 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0161 0.0327
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0316
Mycobacterium ulcerans hypothetical protein 0.0024 0.0091 0.1032
Mycobacterium ulcerans putative regultory protein 0.0026 0.0106 0.1259
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0357 0.0337
Mycobacterium tuberculosis Conserved protein 0.0035 0.0161 0.1056
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0106 0.0294
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0091 0.1032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0439
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0175 0.036
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0106 0.562
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0063 0.0626
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0106 0.4547
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0193
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0293 0.0901
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0063 0.0146
Echinococcus granulosus microtubule associated protein 2 0.0689 0.4291 1
Onchocerca volvulus 0.0104 0.0596 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0053 0.0469
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0053 0.0469
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0053 0.0469
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0469 0.2902 0.2887
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0172 1
Brugia malayi topoisomerase 0.0019 0.0063 0.0218
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0106 0.1259
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0106 0.562
Loa Loa (eye worm) beta-lactamase 0.0035 0.0161 0.0439
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0106 0.4547
Mycobacterium tuberculosis Conserved protein 0.0026 0.0106 0.064
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0357 0.1166
Brugia malayi Cytochrome P450 family protein 0.0018 0.0053 0.0182
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0053 0.2102
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0063 0.0218
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0091 0.1059
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0526 0.3818
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.2262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0106 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0172 0.0478
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0106 0.0294
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0694 0.1577
Echinococcus granulosus tar DNA binding protein 0.0061 0.0328 0.0718
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0106 0.0294
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0284 0.2349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0195
Brugia malayi Cytochrome P450 family protein 0.0056 0.0293 0.1011
Echinococcus multilocularis cpg binding protein 0.003 0.0133 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0328 0.0718
Mycobacterium tuberculosis Conserved protein 0.0035 0.0161 0.1056
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.4291 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0328 0.0718
Loa Loa (eye worm) cytochrome P450 0.0018 0.0053 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0408 0.0905
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0053 0.011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0161 0.1056
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0328 0.0307
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0106 0.0294
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0035 0.0732
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0035 0.0732
Echinococcus multilocularis heat shock protein 90 0.0026 0.0106 0.0085
Echinococcus granulosus neuropeptide s receptor 0.0447 0.2762 0.6419
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0106 0.562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0259 0.0557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0035 0.012
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0063 0.2262
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0526 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0193 0.9196
Echinococcus multilocularis muscleblind protein 0.0149 0.0883 0.0864
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.0976 0.3315
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0161 0.7495
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.2875 0.2859
Echinococcus granulosus heat shock protein 90 0.0026 0.0106 0.0198
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0063 0.2262
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0053 0.0239
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0106 0.0365
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0053 0.0469
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0063
Brugia malayi TAR-binding protein 0.0061 0.0328 0.1129
Schistosoma mansoni alpha-glucosidase 0.0154 0.0916 0.2096
Schistosoma mansoni hypothetical protein 0.0018 0.0053 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0053 0.0239
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0106 0.1259
Brugia malayi hypothetical protein 0.0074 0.0408 0.1404
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0106 0.4547
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0328 0.1129
Entamoeba histolytica hypothetical protein 0.0074 0.0408 0.7073
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0526 0.3818
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0161 0.1056
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.1074 0.3701
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0328 0.1021
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0053 0.0469
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0053 0.0469
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0106 0.1259
Mycobacterium tuberculosis Conserved protein 0.0035 0.0161 0.1056
Leishmania major trypanothione reductase 0.0037 0.0172 0.0523
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0571 0.1289
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0106 0.0294
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0063 0.0541
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0161 0.014
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0106 0.4547
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0035 0.0732
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0106 0.0294
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0106 0.0248
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0106 0.562
Echinococcus multilocularis GPCR, family 2 0.0034 0.0156 0.0135
Echinococcus granulosus expressed conserved protein 0.0092 0.0524 0.1178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0156 0.0135
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0248
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0106 0.1349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0063 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0053 0.0239
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0106 0.0294
Schistosoma mansoni patched 1 0.0042 0.0208 0.0436
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0091 0.1032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.062 0.2136
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0106 0.064
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0106 0.0294
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0106 0.1655
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0161 0.2075
Brugia malayi heat shock protein 90 0.0026 0.0106 0.0365
Schistosoma mansoni pyruvate dehydrogenase 0.0443 0.2738 0.6361
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0316
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0357 0.123
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0053 0.0469
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0106 0.1259
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.054 0.1859
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0106 1
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0063 0.2796
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0106 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0193 0.0595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0259 0.0239
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0313
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0063 0.2262
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0106 0.0294
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0063 0.4974
Giardia lamblia Pms1-like protein 0.0026 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0108 0.0301
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0422
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0091 0.1032
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0357 0.0787
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0106 0.064
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0468 0.3374
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0063 0.0146
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0106 0.1259
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0259 0.0557
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0106 0.064
Schistosoma mansoni topbp1 0.0019 0.0063 0.0099
Loa Loa (eye worm) RNA binding protein 0.0061 0.0328 0.1021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0208 0.0602
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.1074 0.3624
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0106 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.2262
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0106 0.1123
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0313
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0053 0.0239
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.2762 0.2747
Echinococcus multilocularis 0.0018 0.0053 0.0032
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Echinococcus multilocularis heat shock protein 0.0026 0.0106 0.0085
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0106 0.0757
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.062 0.204
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0106 0.0757
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0053 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0161 0.0485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.062 0.2136
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1345 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0122 0.0421
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0106 0.064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0156 0.0422
Echinococcus multilocularis nibrin 0.0019 0.0063 0.0042
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0053 0.0469
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0562 0.0542
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0156 0.0316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0694 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0053 0.0469
Leishmania major cytochrome p450-like protein 0.0018 0.0053 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0091 0.0525
Plasmodium falciparum endoplasmin, putative 0.0026 0.0106 0.562
Echinococcus granulosus cpg binding protein 0.003 0.0133 0.0261
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0108 0.0255
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0106 0.0294
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0053 0.0239
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0108 0.0255
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0106 0.4547
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.2762 0.6419
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0193 0.0401
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0408 0.0387
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0053 0.0469
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0408 0.0905
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0248
Leishmania major heat shock protein 83-1 0.0026 0.0106 0.0294
Brugia malayi RNA binding protein 0.0061 0.0328 0.1129
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0193 0.9196
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0161 0.7495
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0161 0.2075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Trypanosoma brucei heat shock protein, putative 0.0026 0.0106 0.0294
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0106 0.1259
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0091 0.0525
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0099
Chlamydia trachomatis DNA ligase 0.0019 0.0063 0.4974
Onchocerca volvulus 0.0035 0.0161 0.259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0053 0.024
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0053 0.0074
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0106 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0164 0.0976 0.3315
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0053 0.0239
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0161 0.1056
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1074 0.1055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0193
Mycobacterium ulcerans lipase LipD 0.0035 0.0161 0.2075
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0405 0.1396
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0193 0.9196
Schistosoma mansoni hypothetical protein 0.0041 0.0198 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0259 0.0557
Trypanosoma brucei glucosidase, putative 0.004 0.0193 0.0595
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0053 0.0469
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0091 0.0241
Mycobacterium tuberculosis Probable reductase 0.0083 0.0468 0.3374
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0562 0.1266

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.25 mg kg-1 In vivo antihistaminic activity using compound 48/80 induced lethality test after 1 hr of subcutaneous administration in rat ChEMBL. 3934386
ED50 (functional) > 2.5 mg kg-1 In vivo antihistaminic activity using compound 48/80 induced lethality test in rat after 2 hr of oral administration ChEMBL. 3934386

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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