Detailed information for compound 932113

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.316 | Formula: C19H14BrN5OS
  • H donors: 1 H acceptors: 2 LogP: 4.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1nn(cc1/C=N\NC1=NC(=O)CS1)c1ccccc1
  • InChi: 1S/C19H14BrN5OS/c20-15-8-6-13(7-9-15)18-14(10-21-23-19-22-17(26)12-27-19)11-25(24-18)16-4-2-1-3-5-16/h1-11H,12H2,(H,22,23,26)/b21-10-
  • InChiKey: WFPMYCBPVMDNJN-FBHDLOMBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Ovis aries Cyclooxygenase-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0144 0.083 0.1312
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0037 0.0147 0.0233
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0032 0.0051
Trypanosoma brucei PAB1-binding protein , putative 0.0031 0.011 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0247 0.1489 0.2336
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0009 0.0014
Trichomonas vaginalis hypothetical protein 0.0468 0.2901 0.4589
Onchocerca volvulus 0.0048 0.0215 0.123
Trypanosoma brucei transcription factor BTF3, putative 0.002 0.0039 0.0022
Onchocerca volvulus 0.0082 0.0433 0.2732
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0032 0.0114 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0042 0.0179 0.0285
Echinococcus multilocularis beta LACTamase domain containing family member 0.0247 0.1489 0.2367
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0046
Brugia malayi hypothetical protein 0.0031 0.011 0.0167
Brugia malayi transcription factor E74 isoform 0.002 0.0035 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0144 0.083 0.132
Echinococcus multilocularis ETS transcription factor Elf 2 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Loa Loa (eye worm) blistered cuticle protein 3 0.0048 0.0215 0.0337
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0075 0.0391 0.0584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Onchocerca volvulus Peroxidase homolog 0.0048 0.0215 0.123
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0149 0.0865 0.1375
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.1489 0.2336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0076 0.0121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0349 0.0555
Schistosoma mansoni 6-phosphofructokinase 0.0104 0.0578 0.0918
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.0269 0.042
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0416 0.257 0.4084
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.1489 0.2336
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0086 0.0127
Brugia malayi Bromodomain containing protein 0.0082 0.0437 0.0687
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0015 0.0009 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0149 0.0865 0.1375
Echinococcus granulosus lamin dm0 0.0028 0.0088 0.014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.009 0.1175
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0998 0.6292 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Schistosoma mansoni elf1 0.002 0.0035 0.0056
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0121
Schistosoma mansoni cpg binding protein 0.0088 0.0474 0.0753
Entamoeba histolytica phosphofructokinase, putative 0.0104 0.0578 0.0881
Giardia lamblia Methionyl-tRNA synthetase 0.0032 0.0114 0.147
Schistosoma mansoni intermediate filament proteins 0.0028 0.0088 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.002 0.0035 0.0052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.008 0.042 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0104 0.0578 0.0881
Mycobacterium ulcerans esterase/lipase LipP 0.0247 0.1489 0.8676
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0247 0.1489 0.1468
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0072 0.0368 0.0344
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0111 0.0136
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Brugia malayi Peroxidasin 0.0048 0.0215 0.0333
Toxoplasma gondii hypothetical protein 0.0086 0.0462 0.2982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0045 0.0071
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0998 0.6292 1
Echinococcus granulosus 6 phosphofructokinase 0.0104 0.0578 0.0918
Echinococcus granulosus ETS transcription factor Elf 5 0.002 0.0035 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.002 0.0035 0.0052
Schistosoma mansoni gabp alpha 0.0135 0.0773 0.1228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0262 0.1589 0.2525
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.0215 0.0337
Brugia malayi Animal haem peroxidase family protein 0.0048 0.0215 0.0333
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.002 0.0036 0.0053
Loa Loa (eye worm) ets-domain-containing protein 0.002 0.0035 0.0052
Echinococcus multilocularis ETS domain containing protein Elk 1 0.002 0.0035 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0077 0.0119
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0028 0.0004
Loa Loa (eye worm) phosphofructokinase 0.0104 0.0578 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Echinococcus granulosus neuropeptide receptor A26 0.0353 0.2166 0.3442
Brugia malayi phosphofructokinase 0.0104 0.0578 0.091
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0028 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0048 0.0077
Brugia malayi MH2 domain containing protein 0.0148 0.0859 0.1357
Brugia malayi beta-lactamase family protein 0.0247 0.1489 0.236
Echinococcus multilocularis survival motor neuron protein 1 0.0144 0.083 0.132
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Schistosoma mansoni zinc finger protein 0.0032 0.0118 0.0187
Loa Loa (eye worm) CXXC zinc finger family protein 0.0082 0.0433 0.0685
Loa Loa (eye worm) fli-1 protein 0.0409 0.2529 0.4017
Schistosoma mansoni microtubule-associated protein tau 0.0399 0.2463 0.3914
Echinococcus multilocularis lamin dm0 0.0028 0.0088 0.014
Mycobacterium ulcerans lipase LipD 0.0247 0.1489 0.8676
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0281
Loa Loa (eye worm) 6-phosphofructokinase 0.0104 0.0578 0.0914
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0026 0.0037
Echinococcus multilocularis GPCR, family 2 0.0026 0.0076 0.0121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0006 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0266 0.1644
Mycobacterium tuberculosis Probable lipase LipE 0.0247 0.1489 0.1468
Plasmodium vivax methionine--tRNA ligase, putative 0.0032 0.0114 0.0173
Entamoeba histolytica aminopeptidase, putative 0.0998 0.6292 1
Plasmodium vivax ataxin-2 like protein, putative 0.0031 0.011 0.0168
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.008 0.042 0.0395
Schistosoma mansoni cpg binding protein 0.0082 0.0433 0.0688
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0262 0.1589 0.2522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0029 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0147 0.0233
Echinococcus multilocularis thioredoxin glutathione reductase 0.0031 0.0111 0.0176
Plasmodium falciparum basic transcription factor 3b, putative 0.002 0.0039 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0076 0.0121
Schistosoma mansoni ets-related 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0075 0.0391 0.0584
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0247 0.1489 0.2364
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Echinococcus multilocularis ETS transcription factor Elf 2 0.002 0.0035 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.011 0.0135
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0077 0.0118
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0998 0.6292 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0262 0.1589 0.2525
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0124 0.0702 0.4621
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0353 0.2166 0.3442
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0535 0.3333 0.5277
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0998 0.6292 0.6283
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0075 0.0391 0.0584
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0199 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0147 0.0233
Schistosoma mansoni hypothetical protein 0.0056 0.0269 0.0428
Brugia malayi acetyltransferase, GNAT family protein 0.0416 0.257 0.4079
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0535 0.3333 0.5277
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0042 0.0179 0.0277
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Trichomonas vaginalis D-aminoacylase, putative 0.0247 0.1489 0.2336
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0077 0.0122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0117 0.0187
Brugia malayi glutathione reductase 0.0031 0.0111 0.0168
Plasmodium falciparum importin beta, putative 0.0056 0.0266 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0039 0.0022
Brugia malayi beta-NAC-like protein 0.002 0.0039 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0026 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0247 0.1489 0.1468
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.007 0.0111
Echinococcus granulosus geminin 0.05 0.3109 0.4941
Toxoplasma gondii thioredoxin reductase 0.0031 0.0111 0.0584
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0205
Onchocerca volvulus Peroxidasin homolog 0.0048 0.0215 0.123
Plasmodium falciparum thioredoxin reductase 0.0031 0.0111 0.0136
Plasmodium falciparum histone acetyltransferase GCN5 0.0112 0.0623 0.0954
Entamoeba histolytica phosphofructokinase, putative 0.0104 0.0578 0.0881
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.009 0.0136
Echinococcus granulosus methionine tRNA synthetase 0.0032 0.0114 0.018
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Mycobacterium tuberculosis Probable dehydrogenase 0.0072 0.0368 0.0344
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0028 0.0018
Brugia malayi Pre-SET motif family protein 0.014 0.0806 0.1273
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0039 0.0022
Schistosoma mansoni bromodomain containing protein 0.0072 0.037 0.0588
Echinococcus granulosus peroxidasin 0.0048 0.0215 0.0341
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0998 0.6292 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.002 0.0035 0.0056
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0124 0.0702 0.1109
Trichomonas vaginalis importin beta-1, putative 0.0045 0.0199 0.0277
Echinococcus granulosus importin subunit beta 1 0.0056 0.0266 0.0423
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0147 0.0233
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0136
Plasmodium vivax thioredoxin reductase, putative 0.0031 0.0111 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0048 0.0077
Echinococcus granulosus methyl CpG binding domain protein 2 0.0015 0.0009 0.0014
Leishmania major cytochrome p450-like protein 0.0026 0.0077 0.0082
Echinococcus multilocularis aspartyl aminopeptidase 0.0998 0.6292 1
Trypanosoma brucei trypanothione reductase 0.0031 0.0111 0.0136
Brugia malayi Thioredoxin reductase 0.0031 0.0111 0.0168
Loa Loa (eye worm) transcription factor SMAD2 0.0148 0.0859 0.1362
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0045 0.0071
Brugia malayi Ets-domain containing protein 0.0135 0.0773 0.122
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0349 0.0555
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0262 0.1589 0.2518
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.009 0.0103
Onchocerca volvulus 0.0048 0.0215 0.123
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0077 0.0305
Brugia malayi Ets-domain containing protein 0.002 0.0035 0.0047
Schistosoma mansoni ap endonuclease 0.0018 0.0026 0.0041
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0135 0.0773 0.1225
Echinococcus granulosus zinc finger protein 0.0032 0.0118 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0039 0.0022
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0468 0.2901 0.4589
Echinococcus granulosus histone acetyltransferase KAT2B 0.0402 0.2482 0.3945
Onchocerca volvulus 0.0048 0.0215 0.123
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0124 0.0702 0.1079
Entamoeba histolytica hypothetical protein 0.002 0.0039 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0262 0.1589 0.2525
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0144 0.083 0.1316
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.0215 0.0337
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.033
Loa Loa (eye worm) hypothetical protein 0.0735 0.461 0.7326
Brugia malayi Blistered cuticle protein 3 0.0048 0.0215 0.0333
Giardia lamblia Histone acetyltransferase GCN5 0.0112 0.0623 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0247 0.1489 0.2361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.0436 0.0684
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Mycobacterium tuberculosis Probable oxidoreductase 0.008 0.042 0.0395
Loa Loa (eye worm) 6-phosphofructokinase 0.0104 0.0578 0.0914
Brugia malayi Pre-SET motif family protein 0.0022 0.0048 0.0068
Schistosoma mansoni methionine-tRNA synthetase 0.0032 0.0114 0.018
Brugia malayi Cytochrome P450 family protein 0.0026 0.0077 0.0114
Leishmania major basic transcription factor 3a, putative 0.002 0.0039 0.0022
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.0215 0.0337
Brugia malayi DNA-binding protein D-ETS-3 0.002 0.0035 0.0047
Plasmodium vivax glutathione reductase, putative 0.0031 0.0111 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0048 0.0077
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0077 0.0122
Onchocerca volvulus Dual oxidase homolog 0.0048 0.0215 0.123
Echinococcus granulosus lamin 0.0028 0.0088 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0229
Trichomonas vaginalis helicase, putative 0.0019 0.0029 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Brugia malayi Fli-1 protein 0.0409 0.2529 0.4014
Brugia malayi hypothetical protein 0.002 0.0039 0.0054
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0032 0.0114 0.0177
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.009 0.0443
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0077 0.0119
Brugia malayi Animal haem peroxidase family protein 0.0048 0.0215 0.0333
Brugia malayi mbt repeat family protein 0.0037 0.0147 0.0224
Onchocerca volvulus 0.0037 0.0147 0.0762
Echinococcus granulosus ETS transcription factor Elf 1 0.002 0.0035 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0247 0.1489 0.2336
Brugia malayi mbt repeat family protein 0.0037 0.0147 0.0224
Toxoplasma gondii histone lysine methyltransferase SET1 0.0168 0.0984 0.6547
Loa Loa (eye worm) beta-lactamase 0.0247 0.1489 0.2364
Schistosoma mansoni importin beta-1 0.0056 0.0266 0.0423
Echinococcus multilocularis geminin 0.05 0.3109 0.4941
Mycobacterium ulcerans beta-lactamase 0.0247 0.1489 0.8676
Toxoplasma gondii ABC1 family protein 0.0247 0.1489 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0535 0.3333 0.5277
Schistosoma mansoni ets-related 0.0409 0.2529 0.4019
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Echinococcus granulosus GPCR family 2 0.0026 0.0076 0.0121
Entamoeba histolytica transcription factor BTF3, putative 0.002 0.0039 0.0022
Entamoeba histolytica hypothetical protein 0.0045 0.0199 0.0277
Echinococcus multilocularis polycomb protein SCMH1 0.0037 0.0147 0.0233
Loa Loa (eye worm) hypothetical protein 0.0115 0.0648 0.1026
Loa Loa (eye worm) D-ets-2 protein 0.002 0.0035 0.0052
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0104 0.0578 0.0751
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0594 0.3712 0.5898
Leishmania major hypothetical protein, conserved 0.0247 0.1489 0.2336
Loa Loa (eye worm) hypothetical protein 0.0082 0.0436 0.0689
Loa Loa (eye worm) thioredoxin reductase 0.0031 0.0111 0.0173
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.007 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0174 0.1024 0.1627
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0077 0.0082
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0076 0.0113
Mycobacterium tuberculosis Probable hydrolase 0.0247 0.1489 0.1468
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.009 0.0443
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0029 0.0098 0.0147
Onchocerca volvulus 0.0028 0.0088 0.036
Plasmodium falciparum methionine--tRNA ligase 0.0032 0.0114 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Echinococcus granulosus polycomb protein SCMH1 0.0037 0.0147 0.0233
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0076 0.0121
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0072 0.0368 0.0412
Echinococcus multilocularis methionine tRNA synthetase 0.0032 0.0114 0.018
Brugia malayi Animal haem peroxidase family protein 0.0048 0.0215 0.0333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.0436 0.0689
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0076 0.0113
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0104 0.0578 1
Leishmania major trypanothione reductase 0.0031 0.0111 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.011 0.0135
Schistosoma mansoni hypothetical protein 0.0594 0.3712 0.5899
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0121
Trichomonas vaginalis phosphofructokinase, putative 0.0104 0.0578 0.0881
Schistosoma mansoni 6-phosphofructokinase 0.0104 0.0578 0.0918
Echinococcus granulosus ETS transcription factor Elf 2 0.002 0.0035 0.0056
Brugia malayi methionyl-tRNA synthetase 0.0032 0.0114 0.0172
Loa Loa (eye worm) hypothetical protein 0.0735 0.461 0.7326
Schistosoma mansoni bromodomain containing protein 0.0019 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0056 0.0269 0.0424
Loa Loa (eye worm) hypothetical protein 0.0998 0.6292 1
Onchocerca volvulus Peroxidase homolog 0.0048 0.0215 0.123
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Trypanosoma cruzi importin beta-1 subunit, putative 0.0045 0.0199 0.0277
Brugia malayi CXXC zinc finger family protein 0.0082 0.0433 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Brugia malayi RNA, U transporter 1 0.0158 0.0923 0.1459
Plasmodium vivax basic transcription factor 3b, putative 0.002 0.0039 0.0055
Loa Loa (eye worm) hypothetical protein 0.0064 0.0318 0.0502
Schistosoma mansoni lamin 0.0028 0.0088 0.014
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0266 0.0423
Onchocerca volvulus 0.0028 0.0088 0.036
Brugia malayi Ets-domain containing protein 0.0135 0.0773 0.122
Leishmania major methionyl-tRNA synthetase, putative 0.0032 0.0114 0.014
Onchocerca volvulus 0.0247 0.1489 1
Brugia malayi Bromodomain containing protein 0.0045 0.0196 0.0303
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Echinococcus granulosus ewsr:fli fusion protein type 0.002 0.0035 0.0056
Echinococcus multilocularis muscleblind protein 0.0735 0.461 0.7327
Schistosoma mansoni lamin 0.0028 0.0088 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.2901 0.4589
Loa Loa (eye worm) aspartyl aminopeptidase 0.0998 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0131
Echinococcus multilocularis cpg binding protein 0.0088 0.0474 0.0753
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0077 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0253 0.153 0.24
Loa Loa (eye worm) MH2 domain-containing protein 0.0148 0.0859 0.1362
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.009 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.1489 0.2336
Schistosoma mansoni hypothetical protein 0.05 0.3109 0.4941
Leishmania major hypothetical protein, conserved 0.0031 0.011 0.0135
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Echinococcus granulosus cpg binding protein 0.0088 0.0474 0.0753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Echinococcus multilocularis SAM and MBT domain containing protein 0.0037 0.0147 0.0233
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0072 0.0368 0.0344
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Schistosoma mansoni hypothetical protein 0.05 0.3109 0.4941
Loa Loa (eye worm) mbt repeat family protein 0.0037 0.0147 0.0229
Brugia malayi beta-lactamase family protein 0.0247 0.1489 0.236
Brugia malayi 6-phosphofructokinase 0.0104 0.0578 0.091
Echinococcus multilocularis ETS transcription factor Elf 1 0.002 0.0035 0.0056
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0998 0.6292 1
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0998 0.6292 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0247 0.1489 0.236
Mycobacterium tuberculosis Conserved protein 0.0247 0.1489 0.1468
Echinococcus granulosus SAM and MBT domain containing protein 0.0037 0.0147 0.0233
Trichomonas vaginalis bromodomain-containing protein, putative 0.0124 0.0702 0.1079
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Mycobacterium tuberculosis Probable reductase 0.0072 0.0368 0.0344
Mycobacterium tuberculosis Conserved hypothetical protein 0.0282 0.1713 0.1692
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0468 0.2901 0.4589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0262 0.1589 0.2525
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0026 0.0041
Mycobacterium ulcerans 6-phosphofructokinase 0.0104 0.0578 0.3271
Onchocerca volvulus 0.0247 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Trichomonas vaginalis phosphofructokinase, putative 0.0104 0.0578 0.0881
Schistosoma mansoni transcription factor btf3 0.002 0.0039 0.0063
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.009 0.0103
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0088 0.0132
Plasmodium falciparum glutathione reductase 0.0031 0.0111 0.0136
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0032 0.0114 0.0088
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0147 0.0233
Mycobacterium ulcerans hypothetical protein 0.0247 0.1489 0.8676
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0247 0.1489 0.1468
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0468 0.2901 0.4589
Schistosoma mansoni peroxidasin 0.0048 0.0215 0.0341
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0998 0.6292 1
Toxoplasma gondii NAC domain-containing protein 0.002 0.0039 0.0095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0028 0.0004
Trypanosoma cruzi transcription factor btf3, putative 0.002 0.0039 0.0022
Onchocerca volvulus Chorion peroxidase homolog 0.0048 0.0215 0.123
Onchocerca volvulus 0.0247 0.1489 1
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0998 0.6292 1
Echinococcus granulosus aspartyl aminopeptidase 0.0998 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0251 0.0395
Plasmodium vivax importin-beta 2, putative 0.0056 0.0266 0.0416
Toxoplasma gondii LsmAD domain-containing protein 0.0031 0.011 0.058
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0104 0.0578 0.0881
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0037 0.0147 0.0762
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0028 0.0045
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0077 0.0119
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0998 0.6292 1
Brugia malayi intermediate filament protein 0.0028 0.0088 0.0132
Loa Loa (eye worm) acetyltransferase 0.0416 0.257 0.4082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0076 0.0121
Echinococcus granulosus transcription factor btf3 0.002 0.0039 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0262 0.1589 0.2525
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0199 0.0277
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Mycobacterium ulcerans hypothetical protein 0.0282 0.1713 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0028 0.0037
Echinococcus granulosus intermediate filament protein 0.0028 0.0088 0.014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.009 0.0103
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0032 0.0114 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.2901 0.4589
Echinococcus granulosus snurportin 1 0.0594 0.3712 0.5899
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0076 0.0117
Echinococcus multilocularis transcription factor btf3 0.002 0.0039 0.0063
Brugia malayi Importin beta-1 subunit 0.0056 0.0266 0.0415
Trypanosoma cruzi transcription factor btf3, putative 0.002 0.0039 0.0022
Schistosoma mansoni hypothetical protein 0.0228 0.1371 0.2179
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Trichomonas vaginalis esterase, putative 0.0247 0.1489 0.2336
Brugia malayi beta-lactamase 0.0247 0.1489 0.236
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.009 0.0103
Loa Loa (eye worm) MBCTL1 0.0042 0.0179 0.0281
Leishmania major importin beta-1 subunit, putative 0.0045 0.0199 0.0277
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0031 0.0111 0.0086
Echinococcus granulosus thioredoxin glutathione reductase 0.0031 0.0111 0.0176
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.009 0.1084
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.009 0.0443
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0042 0.0179 0.0285
Schistosoma mansoni ap endonuclease 0.0018 0.0026 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0266 0.0384
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0028 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0075 0.0391 0.0584
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0028 0.0045
Entamoeba histolytica Ran family GTPase 0.0018 0.0028 0.0004
Toxoplasma gondii methionyl-tRNA synthetase 0.0032 0.0114 0.0601
Schistosoma mansoni ran 0.0018 0.0028 0.0045
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0045 0.0071
Onchocerca volvulus 0.0029 0.0098 0.0426
Loa Loa (eye worm) glutathione reductase 0.0031 0.0111 0.0173
Brugia malayi Aspartyl aminopeptidase 0.0998 0.6292 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0247 0.1489 0.2336
Echinococcus multilocularis histone acetyltransferase MYST2 0.0042 0.0179 0.0285
Echinococcus multilocularis ets variant gene 4 0.002 0.0035 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0262 0.1589 0.2525
Leishmania major ATP-dependent phosphofructokinase 0.0104 0.0578 0.0881
Echinococcus granulosus muscleblind protein 0.0735 0.461 0.7327
Schistosoma mansoni survival motor neuron protein 0.0029 0.0098 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Echinococcus multilocularis neuropeptide s receptor 0.0353 0.2166 0.3442
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0229
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0247 0.1489 0.8676
Loa Loa (eye worm) hypothetical protein 0.0247 0.1489 0.2364
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0117 0.0187
Schistosoma mansoni hypothetical protein 0.0029 0.0098 0.0156
Echinococcus granulosus microtubule associated protein 2 0.0399 0.2463 0.3914
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.007 0.0111
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0029 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.0535 0.3333 0.5277
Onchocerca volvulus 0.0022 0.0048 0.0086
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0077 0.0118
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0998 0.6292 1
Loa Loa (eye worm) ICD-1 protein 0.002 0.0039 0.0059
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0998 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0266 0.0419
Schistosoma mansoni ets 0.002 0.0035 0.0056
Trichomonas vaginalis set domain proteins, putative 0.0159 0.0928 0.144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0247 0.1489 0.2367
Echinococcus multilocularis ETS transcription factor Elf 5 0.002 0.0035 0.0056
Brugia malayi Cytochrome P450 family protein 0.0026 0.0077 0.0114
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0072 0.0368 0.0344
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0088 0.0136
Entamoeba histolytica phosphofructokinase, putative 0.0104 0.0578 0.0881
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.008 0.042 0.0495
Echinococcus granulosus ETS transcription factor Elf 2 0.002 0.0035 0.0056
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0172
Echinococcus multilocularis GA binding protein alpha chain 0.0135 0.0773 0.1228
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0266 0.0384
Plasmodium vivax SET domain protein, putative 0.0022 0.0048 0.0069
Echinococcus granulosus protein C ets 2 0.002 0.0035 0.0056
Echinococcus multilocularis snurportin 1 0.0594 0.3712 0.5899
Echinococcus multilocularis peroxidasin 0.0048 0.0215 0.0341
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0088 0.0136
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0416 0.257 0.4084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0124 0.0702 0.4621
Trichomonas vaginalis ran, putative 0.0018 0.0028 0.0004
Brugia malayi Muscleblind-like protein 0.0735 0.461 0.7324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0262 0.1589 0.2525
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0042 0.0179 0.0285
Echinococcus granulosus histone acetyltransferase MYST2 0.0042 0.0179 0.0285
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0009 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0029 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0029 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0072 0.0368 0.0344
Loa Loa (eye worm) hypothetical protein 0.0998 0.6292 1
Mycobacterium tuberculosis Conserved protein 0.0247 0.1489 0.1468
Brugia malayi hypothetical protein 0.0048 0.0215 0.0333
Mycobacterium leprae conserved hypothetical protein 0.0247 0.1489 0.2227
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0104 0.0578 0.0881
Onchocerca volvulus 0.0159 0.0928 0.6137
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0032 0.0114 0.014
Mycobacterium tuberculosis Probable esterase LipL 0.0247 0.1489 0.1468
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0032 0.0114 0.014
Leishmania major GTP-binding protein, putative 0.0018 0.0028 0.0004
Brugia malayi Animal haem peroxidase family protein 0.0048 0.0215 0.0333
Brugia malayi Animal haem peroxidase family protein 0.0048 0.0215 0.0333
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0147 0.0233
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0092 0.0497 0.0752
Schistosoma mansoni cpg binding protein 0.0088 0.0474 0.0753
Trichomonas vaginalis phosphofructokinase, putative 0.0104 0.0578 0.0881
Brugia malayi 6-phosphofructokinase 0.0104 0.0578 0.091
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0048 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0247 0.1489 0.2367
Echinococcus granulosus histone acetyltransferase KAT2B 0.0124 0.0702 0.1116
Brugia malayi PHD-finger family protein 0.0037 0.0148 0.0227
Mycobacterium tuberculosis Probable lipase LipD 0.0247 0.1489 0.1468
Loa Loa (eye worm) animal heme peroxidase 0.0048 0.0215 0.0337
Echinococcus multilocularis musashi 0.0028 0.0088 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.0436 0.0684
Echinococcus multilocularis zinc finger protein 0.0032 0.0118 0.0187
Mycobacterium tuberculosis Conserved protein 0.0247 0.1489 0.1468
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.2901 0.4589
Mycobacterium leprae Probable lipase LipE 0.0247 0.1489 0.2227
Echinococcus granulosus beta LACTamase domain containing family member 0.0247 0.1489 0.2367
Echinococcus multilocularis muscleblind protein 1 0.0735 0.461 0.7327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0147 0.0233
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0253 0.153 0.24
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0253 0.153 0.24
Plasmodium falciparum ataxin-2 like protein, putative 0.0031 0.011 0.0135
Trypanosoma cruzi PAB1-binding protein , putative 0.0031 0.011 0.0135
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0998 0.6292 1
Onchocerca volvulus Peroxidasin homolog 0.0048 0.0215 0.123
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0028 0.0004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.009 0.5
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0104 0.0578 0.0553
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0028 0.0004
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.0121
Echinococcus multilocularis lamin 0.0028 0.0088 0.014
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0026 0.0032
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0032 0.0114 0.0521
Entamoeba histolytica acetyltransferase, GNAT family 0.0112 0.0623 0.0954
Echinococcus multilocularis microtubule associated protein 2 0.0399 0.2463 0.3914
Echinococcus granulosus GA binding protein alpha chain 0.0135 0.0773 0.1228
Echinococcus granulosus neuropeptide s receptor 0.0353 0.2166 0.3442
Echinococcus multilocularis protein C ets 2 0.002 0.0035 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0026 0.0041
Echinococcus multilocularis 6 phosphofructokinase 0.0104 0.0578 0.0918
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0998 0.6292 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.014 0.0806 0.1277
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0029 0.0005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0028 0.0036
Echinococcus granulosus ETS domain containing protein Elk 1 0.002 0.0035 0.0056
Schistosoma mansoni ran 0.0018 0.0028 0.0045
Schistosoma mansoni peroxidasin 0.0048 0.0215 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0247 0.1489 0.2336
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0045 0.0071
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0998 0.6292 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0045 0.0071
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.009 0.0103
Loa Loa (eye worm) hypothetical protein 0.0048 0.0215 0.0337
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0077 0.0082

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.66 uM Inhibition of ovine COX2 ChEMBL. 25444084
IC50 (binding) = 66.33 uM Inhibition of ovine COX1 ChEMBL. 25444084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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