Detailed information for compound 934754

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.28 | Formula: C17H16N2O4Se
  • H donors: 1 H acceptors: 1 LogP: 2.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1n[se]nc1c1ccc(cc1)O
  • InChi: 1S/C17H16N2O4Se/c1-21-13-8-11(9-14(22-2)17(13)23-3)16-15(18-24-19-16)10-4-6-12(20)7-5-10/h4-9,20H,1-3H3
  • InChiKey: PJNXMZYGOQZUNE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis bmru protein, putative 0.0083 0.0222 0.2136
Schistosoma mansoni hypothetical protein 0.0052 0.0073 0.0073
Schistosoma mansoni survival motor neuron protein 0.0052 0.0073 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Mycobacterium ulcerans diacylglycerol kinase 0.0083 0.0222 0.0222
Brugia malayi Doublecortin family protein 0.0041 0.0023 0.0224
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Schistosoma mansoni diacylglycerol kinase theta 0.0083 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Echinococcus multilocularis ceramide kinase 0.0083 0.0222 0.0222
Schistosoma mansoni polycystin 1-related 0.0041 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.2122 1 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0083 0.0222 0.2136
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0011 0.048
Trypanosoma cruzi cytochrome P450, putative 0.0081 0.0213 0.9569
Mycobacterium ulcerans beta-lactamase 0.0038 0.0011 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.005 0.0065 0.0054
Onchocerca volvulus 0.0057 0.01 0.0956
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0023
Brugia malayi Diacylglycerol kinase protein 2 0.0083 0.0222 0.2136
Echinococcus granulosus Diacylglycerol kinase theta 0.0083 0.0222 0.0222
Trypanosoma brucei cytochrome P450, putative 0.0081 0.0213 0.9569
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0011 0.0102
Onchocerca volvulus Ceramide kinase 1 homolog 0.0083 0.0222 0.2276
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0065 0.2923
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.005 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.005 0.0065 0.0065
Schistosoma mansoni diacylglycerol kinase theta 0.0083 0.0222 0.0222
Onchocerca volvulus 0.0083 0.0222 0.2276
Loa Loa (eye worm) hypothetical protein 0.0083 0.0222 0.0222
Mycobacterium ulcerans hypothetical protein 0.2122 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.1005 0.0995
Loa Loa (eye worm) hypothetical protein 0.0083 0.0222 0.0222
Brugia malayi beta-lactamase 0.0038 0.0011 0.0102
Schistosoma mansoni cytochrome P450 0.005 0.0065 0.0065
Loa Loa (eye worm) cytochrome P450 0.005 0.0065 0.0065
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.1042 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0011 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0806 0.0806
Onchocerca volvulus 0.0041 0.0023 0.0136
Trypanosoma cruzi cytochrome P450, putative 0.0081 0.0213 0.9569
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0011 0.0011
Brugia malayi hypothetical protein 0.0083 0.0222 0.2136
Trypanosoma cruzi diacylglycerol kinase, putative 0.0083 0.0222 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0023 0.0597
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0083 0.0222 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0073 0.0704
Trypanosoma cruzi Sphingosine kinase 0.0083 0.0222 1
Brugia malayi beta-lactamase family protein 0.0038 0.0011 0.0102
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.005 0.0065 0.0054
Schistosoma mansoni rab6-interacting 0.0041 0.0023 0.0023
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0246 0.1006 0.1006
Echinococcus granulosus cytochrome P450 2K1 0.005 0.0065 0.0065
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0083 0.0222 0.0222
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.005 0.0065 0.0065
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1038 0.1038
Trypanosoma cruzi Sphingosine kinase 0.0083 0.0222 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Brugia malayi Ceramide kinase 0.0083 0.0222 0.2136
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.005 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.005 0.0065 0.0054
Brugia malayi diacylglycerol kinase 0.0083 0.0222 0.2136
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.0117 0.0388 0.3725
Toxoplasma gondii ABC1 family protein 0.0038 0.0011 0.048
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0081 0.0213 0.0213
Trypanosoma cruzi diacylglycerol kinase, putative 0.0083 0.0222 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0065 0.2923
Trypanosoma cruzi cytochrome p450-like protein, putative 0.005 0.0065 0.2923
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0053 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Plasmodium falciparum diacylglycerol kinase, putative 0.0083 0.0222 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0213 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.005 0.0065 0.0054
Plasmodium vivax diacylglycerol kinase, putative 0.0083 0.0222 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.005 0.0065 0.0065
Schistosoma mansoni lipoxygenase 0.0246 0.1006 0.1006
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.005 0.0065 0.0054
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.1042 0.1042
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.005 0.0065 0.0054
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.005 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.005 0.0065 0.0065
Schistosoma mansoni sphingosine kinase A B 0.2122 1 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.005 0.0065 0.2923
Schistosoma mansoni hypothetical protein 0.0083 0.0222 0.0222
Schistosoma mansoni rab6-interacting 0.0041 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0253 0.1038 0.1038
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0083 0.0222 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0388 0.0388
Leishmania major cytochrome p450-like protein 0.005 0.0065 0.2923
Leishmania major cytochrome p450-like protein 0.005 0.0065 0.2923
Leishmania major sphingosine kinase A, B, putative 0.0083 0.0222 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0053 0.0508
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0083 0.0222 0.2136
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0624 0.6589
Onchocerca volvulus 0.0233 0.0941 1
Mycobacterium tuberculosis Diacylglycerol kinase 0.0083 0.0222 0.0212
Onchocerca volvulus 0.0052 0.0073 0.0674
Mycobacterium leprae putative cytochrome p450 0.005 0.0065 1
Echinococcus multilocularis sphingosine kinase 1 0.2122 1 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.005 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.005 0.0065 0.0065
Entamoeba histolytica diacylglycerol kinase, putative 0.0083 0.0222 0.0222
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0083 0.0222 0.2136
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.005 0.0065 0.0054
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0083 0.0222 0.0222
Echinococcus multilocularis RUN 0.0041 0.0023 0.0023
Brugia malayi Cytochrome P450 family protein 0.0081 0.0213 0.2044
Loa Loa (eye worm) diacylglycerol kinase 2 0.0083 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Plasmodium falciparum diacylglycerol kinase, putative 0.0083 0.0222 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0023 0.0023
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.005 0.0065 0.0054
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0011 0.048
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.005 0.0065 0.0054
Brugia malayi Eye-specific diacylglycerol kinase 0.0083 0.0222 0.2136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.005 0.0065 0.0065
Trichomonas vaginalis diacylglycerol kinase, putative 0.0083 0.0222 0.2136
Echinococcus granulosus RUN 0.0041 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Mycobacterium tuberculosis Conserved protein 0.2122 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.005 0.0065 0.0065
Loa Loa (eye worm) ceramide kinase 0.0083 0.0222 0.0222
Schistosoma mansoni sphingoid long chain base kinase 0.2122 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.01 0.01
Echinococcus multilocularis Diacylglycerol kinase theta 0.0083 0.0222 0.0222
Loa Loa (eye worm) beta-lactamase 0.0038 0.0011 0.0011
Entamoeba histolytica hypothetical protein, conserved 0.2122 1 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.005 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.005 0.0065 0.0054
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.005 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.005 0.0065 0.0054
Leishmania major hypothetical protein, conserved 0.0083 0.0222 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0083 0.0222 0.0222
Trichomonas vaginalis sphingosine kinase, putative 0.0083 0.0222 0.2136
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0011 0.048
Echinococcus granulosus Diacylglycerol kinase zeta 0.0083 0.0222 0.0222
Leishmania major cytochrome p450-like protein 0.0081 0.0213 0.9569
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.005 0.0065 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0011 0.0102
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.005 0.0065 0.0054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0083 0.0222 0.0222
Trichomonas vaginalis esterase, putative 0.0038 0.0011 0.0102
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.005 0.0065 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.005 0.0065 0.0054
Trypanosoma brucei diacylglycerol kinase, putative 0.0083 0.0222 1
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0083 0.0222 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.005 0.0065 0.0065
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0023 0.0023
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.005 0.0065 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0184 0.0709 0.0709
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0038 0.0011 0.048
Brugia malayi Cytochrome P450 family protein 0.0081 0.0213 0.2044
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0083 0.0222 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0011 0.0011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0023 0.0023
Brugia malayi hypothetical protein 0.0041 0.0023 0.0224
Loa Loa (eye worm) CYP4Cod1 0.0081 0.0213 0.0213
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0083 0.0222 0.2136
Brugia malayi cytochrome P450 0.005 0.0065 0.0624
Leishmania major diacylglycerol kinase-like protein 0.0083 0.0222 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0388 0.0388
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0053 0.0053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0246 0.1006 0.1006
Mycobacterium ulcerans hypothetical protein 0.0038 0.0011 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.005 0.0065 0.0054
Echinococcus granulosus ceramide kinase 0.0083 0.0222 0.0222
Echinococcus multilocularis tumor protein p63 0.039 0.1694 0.1694
Mycobacterium leprae Conserved hypothetical protein 0.005 0.0065 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0053 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0053 0.0053
Trichomonas vaginalis bmru protein, putative 0.0083 0.0222 0.2136
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0083 0.0222 0.0222
Plasmodium vivax diacylglycerol kinase, putative 0.0083 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0222 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.005 0.0065 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.005 0.0065 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0057 0.01 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0011 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.005 0.0065 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.005 0.0065 0.0054
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.005 0.0065 0.0065
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0083 0.0222 1
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0083 0.0222 0.0222
Echinococcus granulosus tumor protein p63 0.039 0.1694 0.1694
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0222 0.2136
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0011 0.0102
Brugia malayi diacylglycerol kinase 0.0083 0.0222 0.2136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0053 0.0053
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0023 0.0023
Schistosoma mansoni lipoxygenase 0.0172 0.0651 0.0651
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0667 0.64
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0083 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0083 0.0222 1
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1038 0.1038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0011 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0053 0.0053
Onchocerca volvulus 0.0041 0.0023 0.0136
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0023 0.0023
Brugia malayi Pre-SET motif family protein 0.0204 0.0806 0.7735
Leishmania major lanosterol 14-alpha-demethylase, putative 0.005 0.0065 0.2923
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Brugia malayi Cytochrome P450 family protein 0.005 0.0065 0.0624
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0083 0.0222 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.005 0.0065 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0941 0.9034
Leishmania major diacylglycerol kinase, putative 0.0083 0.0222 1
Schistosoma mansoni hypothetical protein 0.005 0.0065 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0053 0.0053
Echinococcus multilocularis 0.005 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.005 0.0065 0.0065
Toxoplasma gondii cytochrome p450 superfamily protein 0.005 0.0065 0.2923
Brugia malayi Cytochrome P450 family protein 0.0184 0.0709 0.6806
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.005 0.0065 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0624 0.5987
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0667 0.64
Entamoeba histolytica diacylglycerol kinase, putative 0.0083 0.0222 0.0222
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0023 0.0023
Brugia malayi hypothetical protein 0.0253 0.1038 0.9965
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1042 1
Trichomonas vaginalis sphingosine kinase, putative 0.0083 0.0222 0.2136
Mycobacterium ulcerans lipase LipD 0.0038 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0038 0.0011 0.0102
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0102
Trypanosoma brucei Sphingosine kinase 0.0083 0.0222 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0011 0.0102
Schistosoma mansoni loxhd1 0.0041 0.0023 0.0023
Entamoeba histolytica diacylglycerol kinase, putative 0.0083 0.0222 0.0222
Toxoplasma gondii diacylglycerol kinase, putative 0.0083 0.0222 1
Brugia malayi hypothetical protein 0.0041 0.0023 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0222 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.005 0.0065 0.0065

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 15.81 uM Antiproliferative activity against human KB cells after 72 hrs by MTT assay ChEMBL. 25233100

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25233100

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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