TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 316.247 | Formula: C12H17N2O6P
H donors: 4 H acceptors: 6 LogP: -1.17 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(O)C)CCC(P(=O)(O)O)NC(=O)c1ccccc1
InChi: 1S/C12H17N2O6P/c1-14(17)11(15)8-7-10(21(18,19)20)13-12(16)9-5-3-2-4-6-9/h2-6,10,17H,7-8H2,1H3,(H,13,16)(H2,18,19,20)
InChiKey: DIHZMVOBBRRTTG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	glutaminase DH11.1	0.0269	0.2407	0.2378
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4747	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0156	0.1345	0.1792
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0084	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	hypothetical protein	0.017	0.1479	0.483
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0249	0.2213	0.2183
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	g-protein coupled receptor	0.0156	0.1345	0.1792
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1017	0.0982
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0563	0.184
Onchocerca volvulus		0.0156	0.1345	0.6337
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0156	0.1345	0.4394
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0468	0.0537
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0084	0.0045
Brugia malayi	Pre-SET motif family protein	0.0031	0.0176	0.0139
Schistosoma mansoni	amine GPCR	0.0156	0.1345	0.4394
Brugia malayi	Cytochrome P450 family protein	0.0055	0.0406	0.0369
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0084	0.0045
Mycobacterium leprae	putative cytochrome p450	0.0037	0.0236	0.01
Brugia malayi	hypothetical protein	0.0026	0.0134	0.0096
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0037	0.0236	0.0023
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0037	0.0236	0.3757
Echinococcus granulosus	GPCR family 2	0.0079	0.0626	0.2044
Loa Loa (eye worm)	cytochrome P450	0.0037	0.0236	0.0198
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0468	0.0537
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0037	0.0236	0.0023
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0037	0.0236	0.0023
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0563	0.1266
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0037	0.0236	0.0023
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0156	0.1345	0.1312
Schistosoma mansoni	hypothetical protein	0.0156	0.1345	0.4394
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0156	0.1345	0.4394
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0055	0.0406	0.0401
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0079	0.0626	0.2044
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.046	0.4186	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0037	0.0236	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0037	0.0236	0.0475
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0084	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0176	0.0139
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0084	0.0045
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0084	0.0273
Brugia malayi	G-protein coupled receptor	0.0156	0.1345	0.1312
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0134	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0626	0.059
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4747	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0468	0.1035
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0176	0.0576
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0134	0.182
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Echinococcus multilocularis	neuropeptide receptor	0.0156	0.1345	0.1792
Brugia malayi	putative neuropeptide receptor	0.0156	0.1345	0.1312
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0084	0.0112
Mycobacterium leprae	Conserved hypothetical protein	0.0037	0.0236	0.01
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0156	0.1345	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	histamine h1 receptor	0.0156	0.1345	0.4394
Brugia malayi	steroid hormone receptor	0.0021	0.0084	0.0045
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0037	0.0236	0.0475
Echinococcus granulosus	tm gpcr rhodopsin	0.0156	0.1345	0.4394
Brugia malayi	Inositol-1	0.0036	0.0225	0.0187
Loa Loa (eye worm)	CYP4Cod1	0.0055	0.0406	0.0369
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0084	0.0273
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0156	0.1345	0.4394
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0037	0.0236	0.0475
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0137	0.1168	0.1134
Echinococcus granulosus	g protein coupled receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0084	0.0273
Echinococcus granulosus	somatostatin receptor	0.0156	0.1345	0.4394
Brugia malayi	neuropeptide F receptor	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	neuropeptide receptor	0.0156	0.1345	0.4394
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0563	0.1115
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0156	0.1345	0.1792
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0388	0.0517
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0037	0.0236	0.0023
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0156	0.1345	0.1792
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0563	0.0748
Schistosoma mansoni	tar DNA-binding protein	0.0319	0.2869	0.9373
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0084	0.0112
Schistosoma mansoni	hypothetical protein	0.0079	0.0626	0.2044
Brugia malayi	Serotonin receptor	0.0156	0.1345	0.1312
Echinococcus multilocularis	neuropeptide receptor A26	0.0156	0.1345	0.1792
Onchocerca volvulus		0.0156	0.1345	0.6337
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0037	0.0236	0.0023
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0037	0.0236	0.3757
Echinococcus multilocularis	neuropeptide Y receptor	0.0156	0.1345	0.1792
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0037	0.0236	0.0023
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0037	0.0236	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0084	0.0045
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0468	0.818
Echinococcus multilocularis	g protein coupled receptor	0.0156	0.1345	0.1792
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0155	0.0505
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0225	0.3555
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0468	0.0912
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0563	0.2298
Brugia malayi	beta-lactamase family protein	0.0072	0.0563	0.0527
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0037	0.0236	0.0419
Schistosoma mansoni	tar DNA-binding protein	0.0319	0.2869	0.9373
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0247	0.033
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0079	0.0626	0.059
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Echinococcus multilocularis	g protein coupled receptor	0.0156	0.1345	0.1792
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Onchocerca volvulus		0.0072	0.0563	0.2409
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0563	0.1266
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0176	0.0293
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0037	0.0236	0.0475
Echinococcus multilocularis	dro:myosuppressin receptor	0.0156	0.1345	0.1792
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0328	0.1227
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0156	0.1345	0.1312
Schistosoma mansoni	biogenic amine receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	neuropeptides capa receptor	0.0156	0.1345	0.1792
Brugia malayi	nuclear hormone receptor	0.0021	0.0084	0.0045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0156	0.1345	0.4394
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0037	0.0236	0.0475
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	neuropeptide receptor	0.0156	0.1345	0.1792
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0037	0.0236	0.0023
Echinococcus granulosus	serotonin receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	TYRA-2 protein	0.0156	0.1345	0.1312
Echinococcus granulosus	hypothetical protein	0.0156	0.1345	0.4394
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0084	0.0045
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0084	0.0112
Onchocerca volvulus		0.0156	0.1345	0.6337
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0507	0.8924
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0068	0.0221
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0507	0.8924
Echinococcus granulosus	neuropeptide FF receptor 2	0.0156	0.1345	0.4394
Echinococcus granulosus	dro:myosuppressin receptor	0.0156	0.1345	0.4394
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0176	0.0235
Onchocerca volvulus		0.0156	0.1345	0.6337
Echinococcus granulosus	g-protein coupled receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0084	0.0112
Brugia malayi	latrophilin 2 splice variant baaae	0.017	0.1479	0.1446
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0037	0.0236	0.0475
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0328	0.0437
Entamoeba histolytica	hypothetical protein	0.0073	0.0576	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0176	0.0576
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0156	0.1345	0.1312
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.1811	0.1779
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0156	0.1345	0.1312
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0156	0.1345	0.4394
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0156	0.1345	0.1312
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0038	0.0051
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1017	0.0982
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0035	0.0114
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0037	0.0236	0.3757
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0563	0.184
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0037	0.0236	0.0475
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0084	0.0045
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0084	0.0273
Brugia malayi	neuropeptide F receptor	0.0156	0.1345	0.1312
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0156	0.1345	0.1792
Onchocerca volvulus		0.0156	0.1345	0.6337
Onchocerca volvulus		0.0058	0.043	0.1737
Brugia malayi	Latrophilin receptor protein 2	0.0079	0.0626	0.059
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0156	0.1345	0.4394
Loa Loa (eye worm)	neuropeptide F receptor	0.0156	0.1345	0.1312
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0507	0.8924
Brugia malayi	G-protein coupled receptor	0.0156	0.1345	0.1312
Entamoeba histolytica	hypothetical protein	0.0073	0.0576	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0084	0.0273
Schistosoma mansoni	coup transcription factor	0.0021	0.0084	0.0273
Echinococcus multilocularis	GPCR, family 2	0.0079	0.0626	0.0834
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0084	0.0273
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Leishmania major	cytochrome p450-like protein	0.0037	0.0236	0.3757
Loa Loa (eye worm)	glutaminase	0.0269	0.2407	0.2378
Schistosoma mansoni	cpg binding protein	0.0058	0.043	0.1403
Schistosoma mansoni	hypothetical protein	0.0284	0.2547	0.8318
Echinococcus granulosus	G protein coupled receptor 139	0.0156	0.1345	0.4394
Echinococcus multilocularis	allatostatin A receptor	0.0156	0.1345	0.1792
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0134	0.182
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0388	0.0517
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0084	0.0045
Schistosoma mansoni	opsin-like receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Schistosoma mansoni	hypothetical protein	0.0079	0.0626	0.2044
Trypanosoma cruzi	cytochrome P450, putative	0.0055	0.0406	0.7007
Echinococcus granulosus	orexin receptor type 2	0.0156	0.1345	0.4394
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0468	0.0537
Echinococcus multilocularis	somatostatin receptor	0.0156	0.1345	0.1792
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	myosin xvIII	0.0156	0.1345	0.4394
Brugia malayi	CXXC zinc finger family protein	0.0058	0.043	0.0393
Brugia malayi	hypothetical protein	0.0017	0.0048	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0035	0.0047
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0563	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0123	0.1043	0.3408
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0563	0.1266
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0563	0.1266
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0038	0.0126
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0563	0.184
Schistosoma mansoni	neuropeptide receptor	0.0156	0.1345	0.4394
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0037	0.0236	0.0023
Brugia malayi	Cytochrome P450 family protein	0.0116	0.0979	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Brugia malayi	Serotonin receptor	0.0156	0.1345	0.1312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0156	0.1345	0.1792
Brugia malayi	Dopamine receptor protein 2	0.0156	0.1345	0.1312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Schistosoma mansoni	hypothetical protein	0.0037	0.0236	0.077
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0507	0.047
Onchocerca volvulus		0.0072	0.0563	0.2409
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0156	0.1345	0.1792
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0084	0.0273
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0249	0.2213	0.2183
Echinococcus granulosus	g protein coupled receptor	0.0156	0.1345	0.4394
Echinococcus granulosus	tm gpcr rhodopsin	0.0156	0.1345	0.4394
Schistosoma mansoni	biogenic amine receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	glutaminase	0.0269	0.2407	0.7863
Echinococcus granulosus	biogenic amine 5HT receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0507	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	Cytochrome P450 family protein	0.0037	0.0236	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	cytochrome P450	0.0037	0.0236	0.0198
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0507	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Entamoeba histolytica	hypothetical protein	0.0073	0.0576	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0328	0.1071
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0084	0.0112
Brugia malayi	Cytochrome P450 family protein	0.0055	0.0406	0.0369
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0156	0.1345	0.1792
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0037	0.0236	0.0023
Echinococcus multilocularis	neuropeptide Y receptor	0.0156	0.1345	0.1792
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0079	0.0626	0.059
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Leishmania major	cytochrome p450-like protein	0.0055	0.0406	0.7007
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	cpg binding protein	0.0061	0.046	0.0613
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0156	0.1345	0.1312
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0084	0.0045
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0563	0.0527
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0037	0.0236	0.0023
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0328	0.1071
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0084	0.0273
Schistosoma mansoni	amine GPCR	0.0156	0.1345	0.4394
Brugia malayi	mbt repeat family protein	0.0047	0.0328	0.0291
Schistosoma mansoni	neuropeptide receptor	0.0156	0.1345	0.4394
Brugia malayi	RNA binding protein	0.0319	0.2869	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus granulosus	7tm_1 domain containing protein	0.0156	0.1345	0.4394
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0037	0.0236	0.0475
Loa Loa (eye worm)	G-protein coupled receptor	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0035	0.0047
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0388	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Schistosoma mansoni	hypothetical protein	0.0156	0.1345	0.4394
Schistosoma mansoni	growth hormone secretagogue receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0038	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Onchocerca volvulus		0.0156	0.1345	0.6337
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0507	0.8027
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0247	0.0808
Loa Loa (eye worm)	G-protein coupled receptor	0.0156	0.1345	0.1312
Schistosoma mansoni	adenoreceptor	0.0156	0.1345	0.4394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Plasmodium vivax	SET domain protein, putative	0.0031	0.0176	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0184	0.1613	0.5267
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0328	0.0291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.1168	0.3816
Loa Loa (eye worm)	neuropeptide F receptor	0.0156	0.1345	0.1312
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0035	0.0114
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0156	0.1345	0.4394
Brugia malayi	mbt repeat family protein	0.0047	0.0328	0.0291
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0084	0.0273
Trypanosoma cruzi	cytochrome P450, putative	0.0055	0.0406	0.7007
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0037	0.0236	0.0475
Onchocerca volvulus		0.0156	0.1345	0.6337
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0563	0.2298
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0563	0.0527
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0084	0.0273
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0084	0.0045
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4747	1
Echinococcus granulosus	g protein coupled receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0563	0.0527
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0079	0.0626	0.0834
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0388	0.1269
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0507	0.8924
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0176	0.0576
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0084	0.0273
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0134	0.0203
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0137	0.1168	0.1557
Entamoeba histolytica	hypothetical protein	0.0073	0.0576	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2213	0.2183
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0137	0.1168	0.3816
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0563	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0576	0.1881
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	hypothetical protein	0.0156	0.1345	0.4394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0084	0.0045
Schistosoma mansoni	cytochrome P450	0.0037	0.0236	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0156	0.1345	0.4394
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0084	0.0045
Echinococcus multilocularis	serotonin receptor	0.0156	0.1345	0.1792
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0225	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0084	0.0045
Schistosoma mansoni	tar DNA-binding protein	0.0319	0.2869	0.9373
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0576	0.0767
Brugia malayi	beta-lactamase family protein	0.0072	0.0563	0.0527
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0563	0.2298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Brugia malayi	GnHR receptor homolog	0.0156	0.1345	0.1312
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0563	0.2298
Onchocerca volvulus		0.0072	0.0563	0.2409
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0084	0.0045
Echinococcus multilocularis	g protein coupled receptor	0.0156	0.1345	0.1792
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0084	0.0273
Brugia malayi	G protein-coupled receptor F59B2.13	0.0156	0.1345	0.1312
Onchocerca volvulus		0.0031	0.0176	0.0466
Onchocerca volvulus		0.0156	0.1345	0.6337
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0225	0.3555
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0084	0.0045
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0225	0.0735
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0134	0.182
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0134	0.0203
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.019	0.0366
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0084	0.0112
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0225	0.0885
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0084	0.0273
Leishmania major	hypothetical protein, conserved	0.0072	0.0563	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0062	0.0023
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0563	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0037	0.0236	0.0475
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0084	0.0045
Onchocerca volvulus		0.0156	0.1345	0.6337
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0037	0.0236	0.0475
Schistosoma mansoni	hypothetical protein	0.0079	0.0626	0.2044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0084	0.0045
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0184	0.1613	0.2149
Mycobacterium ulcerans	glutaminase	0.0269	0.2407	0.4826
Schistosoma mansoni	cpg binding protein	0.0061	0.046	0.1503
Schistosoma mansoni	hypothetical protein	0.0156	0.1345	0.4394
Echinococcus granulosus	neuropeptide s receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus granulosus	neuropeptides capa receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	inositol-1	0.0036	0.0225	0.0187
Schistosoma mansoni	cpg binding protein	0.0061	0.046	0.1503
Echinococcus multilocularis	geminin	0.0339	0.3062	0.4079
Echinococcus multilocularis	sex peptide receptor	0.0156	0.1345	0.1792
Onchocerca volvulus		0.0156	0.1345	0.6337
Echinococcus multilocularis	G protein coupled receptor 139	0.0156	0.1345	0.1792
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0563	0.0819
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0468	0.1528
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.043	0.0393
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0037	0.0236	0.0023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0084	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0815	0.7505	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Loa Loa (eye worm)	hypothetical protein	0.017	0.1479	0.1446
Brugia malayi	G protein-coupled receptor	0.0156	0.1345	0.1312
Echinococcus multilocularis	fmrfamide receptor	0.0156	0.1345	0.1792
Toxoplasma gondii	histone lysine methyltransferase SET1	0.011	0.0921	0.1875
Echinococcus multilocularis	serotonin receptor	0.0156	0.1345	0.1792
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0084	0.0045
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0563	0.0748
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0576	0.1881
Echinococcus granulosus	biogenic amine 5HT receptor	0.0156	0.1345	0.4394
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0084	0.0273
Schistosoma mansoni	hypothetical protein	0.0339	0.3062	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0225	0.3555
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0328	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1513	0.148
Brugia malayi	Dopamine receptor protein 1	0.0156	0.1345	0.1312
Echinococcus granulosus	neuropeptide receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0319	0.2869	0.2842
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0037	0.0236	0.0023
Schistosoma mansoni	neuropeptide F-like receptor	0.0156	0.1345	0.4394
Brugia malayi	putative neuropeptide receptor NPR1	0.0156	0.1345	0.1312
Onchocerca volvulus		0.0156	0.1345	0.6337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.1168	0.3816
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0156	0.1345	0.4394
Onchocerca volvulus		0.0234	0.2074	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0225	0.3555
Echinococcus granulosus	neuropeptide Y receptor	0.0156	0.1345	0.4394
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0037	0.0236	0.3757
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Schistosoma mansoni	amine GPCR	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0079	0.0626	0.0834
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0156	0.1345	0.4394
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0563	0.1266
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0249	0.2213	0.2183
Brugia malayi	RE15519p	0.0156	0.1345	0.1312
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0156	0.1345	0.1792
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0037	0.0236	0.0475
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0156	0.1345	0.1792
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2074	0.861
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0156	0.1345	0.6337
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0156	0.1345	0.6337
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0084	0.0112
Echinococcus granulosus	neuropeptide Y receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0084	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	tar DNA binding protein	0.0319	0.2869	0.3823
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.4747	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0328	0.0437
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0137	0.1168	0.3816
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0563	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0563	0.2298
Schistosoma mansoni	neuropeptide receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis		0.0037	0.0236	0.0314
Loa Loa (eye worm)	RNA binding protein	0.0319	0.2869	0.2842
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0084	0.0273
Echinococcus granulosus	neuropeptide receptor A26	0.0156	0.1345	0.4394
Echinococcus multilocularis	fmrfamide receptor	0.0156	0.1345	0.1792
Brugia malayi	Melatonin receptor type 1A	0.0156	0.1345	0.1312
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0084	0.0273
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0134	0.0203
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0174	0.1513	0.148
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0563	0.0748
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0156	0.1345	0.1792
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0468	0.0623
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0037	0.0236	0.3757
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0156	0.1345	0.4394
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0084	0.0045
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1082	1	1
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0563	0.1266
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0037	0.0236	0.0475
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0137	0.1168	0.1557
Brugia malayi	RNA recognition motif domain containing protein	0.0319	0.2869	0.2842
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0035	0.0114
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0038	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0134	0.0096
Schistosoma mansoni	opsin-like receptor	0.0156	0.1345	0.4394
Onchocerca volvulus		0.0156	0.1345	0.6337
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.4747	1
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0037	0.0236	0.0475
Onchocerca volvulus		0.0156	0.1345	0.6337
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0084	0.0112
Onchocerca volvulus		0.0156	0.1345	0.6337
Echinococcus granulosus	tm gpcr rhodopsin	0.0156	0.1345	0.4394
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0328	0.1071
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0037	0.0236	0.0023
Schistosoma mansoni	hypothetical protein	0.0339	0.3062	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0156	0.1345	0.1312
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0225	0.0735
Leishmania major	hypothetical protein, conserved	0.0026	0.0134	0.182
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	biogenic amine receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	MBCTL1	0.0053	0.0388	0.0351
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.4747	1
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0037	0.0236	0.0023
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0225	0.0885
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0507	0.047
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0156	0.1345	0.1792
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0388	0.1269
Trichomonas vaginalis	esterase, putative	0.0072	0.0563	0.2298
Brugia malayi	ecdysteroid receptor	0.0021	0.0084	0.0045
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0468	0.1528
Mycobacterium ulcerans	lipase LipD	0.0072	0.0563	0.0748
Echinococcus granulosus	cytochrome P450 2K1	0.0037	0.0236	0.077
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0563	0.1266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0225	0.0396
Echinococcus granulosus	sex peptide receptor	0.0156	0.1345	0.4394
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0037	0.0236	0.0023
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.1059	0.2461
Schistosoma mansoni	amine GPCR	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0084	0.0045
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0328	0.1071
Schistosoma mansoni	amine GPCR	0.0156	0.1345	0.4394
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0176	0.0576
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0156	0.1345	0.1312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	AKH receptor	0.0156	0.1345	0.1312
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0388	0.1269
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0156	0.1345	0.1792
Schistosoma mansoni	neuropeptide F-like receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	Pre-SET motif family protein	0.0205	0.1811	0.1779
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0156	0.1345	0.1792
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0563	0.0748
Loa Loa (eye worm)	cytochrome P450 family protein	0.0116	0.0979	0.0944
Echinococcus granulosus	allatostatin A receptor	0.0156	0.1345	0.4394
Brugia malayi	larval opioid receptor	0.0156	0.1345	0.1312
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	tar DNA-binding protein	0.0319	0.2869	0.9373
Echinococcus granulosus	geminin	0.0339	0.3062	1
Brugia malayi	hypothetical protein	0.0073	0.0576	0.054
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Toxoplasma gondii	ABC1 family protein	0.0072	0.0563	0.1115
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	neuropeptide f receptor 76f	0.0156	0.1345	0.4394
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0084	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0068	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0176	0.0576
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0156	0.1345	0.4394
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0038	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0137	0.1168	0.3816
Echinococcus granulosus	rhodopsin orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	MH2 domain containing protein	0.012	0.1017	0.0982
Echinococcus multilocularis	orexin receptor type 2	0.0156	0.1345	0.1792
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0156	0.1345	0.1792
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Echinococcus multilocularis	neuropeptide s receptor	0.0156	0.1345	0.1792
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0084	0.0273
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0156	0.1345	0.1792
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0156	0.1345	0.4394
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0037	0.0236	0.0475
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0507	0.1655
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0038	0.0126
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0225	0.03
Brugia malayi	sulfakinin receptor protein	0.0156	0.1345	0.1312
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0068	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	tar DNA-binding protein	0.0319	0.2869	0.9373
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0156	0.1345	0.4394
Brugia malayi	TAR-binding protein	0.0319	0.2869	0.2842
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0176	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0037	0.0236	0.0475
Onchocerca volvulus		0.0156	0.1345	0.6337
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0037	0.0236	0.0475
Onchocerca volvulus		0.0156	0.1345	0.6337
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0563	0.1266
Echinococcus granulosus	neuropeptides capa receptor	0.0156	0.1345	0.4394
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0156	0.1345	0.4394
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0468	0.1528
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0037	0.0236	0.0023
Schistosoma mansoni	opsin-like receptor	0.0156	0.1345	0.4394
Echinococcus multilocularis	neuropeptides capa receptor	0.0156	0.1345	0.1792
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0084	0.0112
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0037	0.0236	0.0023
Brugia malayi	hypothetical protein	0.0156	0.1345	0.1312
Schistosoma mansoni	hypothetical protein	0.0079	0.0626	0.2044
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Loa Loa (eye worm)	cytochrome P450 family protein	0.0055	0.0406	0.0369
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0037	0.0236	0.0023
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0038	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0563	0.0527
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.1469	0.608
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0084	0.0045
Loa Loa (eye worm)	glutaminase 2	0.0269	0.2407	0.2378
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0066	0.0027
Trypanosoma brucei	cytochrome P450, putative	0.0055	0.0406	0.7007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0084	0.0045
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0079	0.0626	0.2044
Echinococcus granulosus	fmrfamide receptor	0.0156	0.1345	0.4394
Brugia malayi	beta-lactamase	0.0072	0.0563	0.0527
Loa Loa (eye worm)	melatonin receptor type 1A	0.0156	0.1345	0.1312
Echinococcus granulosus	cpg binding protein	0.0061	0.046	0.1503
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0037	0.0236	0.0475
Trichomonas vaginalis	glutaminase, putative	0.0269	0.2407	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0055	0.0406	0.0369
Leishmania major	cytochrome p450-like protein	0.0037	0.0236	0.3757
Onchocerca volvulus		0.0156	0.1345	0.6337
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4747	1
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0328	0.0291
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4747	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0084	0.0273
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0156	0.1345	0.4394
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0084	0.0273
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0137	0.1168	0.1134
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0225	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0388	0.0351
Schistosoma mansoni	hypothetical protein	0.0073	0.0576	0.1881
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0084	0.0045
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0563	0.0819
Brugia malayi	ORL1-like opioid receptor	0.0156	0.1345	0.1312
Loa Loa (eye worm)	TAR-binding protein	0.0319	0.2869	0.2842
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0084	0.0045
Echinococcus granulosus	tar DNA binding protein	0.0319	0.2869	0.9373
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0156	0.1345	0.1792
Echinococcus granulosus	7TM GPCR rhodopsin	0.0156	0.1345	0.4394
Onchocerca volvulus		0.0047	0.0328	0.1227
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0156	0.1345	0.4394
Echinococcus granulosus	neuropeptide receptor	0.0156	0.1345	0.4394
Brugia malayi	Dopamine receptor	0.0156	0.1345	0.1312
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1345	0.1312
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0037	0.0236	0.0475
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0563	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0563	0.1266

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 11 uM	Inhibition of Escherichia coli M15 recombinant IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis	ChEMBL.	25254502
IC50 (functional)	> 50 uM	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA	ChEMBL.	25254502
IC50 (binding)	= 238 uM	Inhibition of Mycobacterium tuberculosis IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis	ChEMBL.	25254502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3342265

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 934844