Detailed information for compound 939704

Basic information

Technical information
  • TDR Targets ID: 939704
  • Name: [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-fluorooxo lan-2-yl]methanol
  • MW: 253.233 | Formula: C10H12FN5O2
  • H donors: 2 H acceptors: 4 LogP: -0.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1F)n1cnc2c1ncnc2N
  • InChi: 1S/C10H12FN5O2/c11-5-1-7(18-6(5)2-17)16-4-15-8-9(12)13-3-14-10(8)16/h3-7,17H,1-2H2,(H2,12,13,14)/t5-,6+,7+/m0/s1
  • InChiKey: CTDUJDNZPPZTAV-RRKCRQDMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-fluoro-tetrahydrofuran-2-yl]methanol
  • [(2R,3S,5R)-5-(6-amino-9-purinyl)-3-fluoro-2-tetrahydrofuranyl]methanol
  • [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-fluoro-oxolan-2-yl]methanol
  • 87418-35-7
  • 9-(3-Fluoro-2,3-dideoxy-beta-D-erythro-pentofuranosyl)adenine
  • 3'-FddA (*.beta.-D-Erythro*)
  • 3'-FddAdo
  • 9-(3-Fluoro-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl)adenine
  • AIDS-000010
  • AIDS000010
  • 3'-FddA (beta-D-Erythro)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cpg binding protein 0.0035 0.0093 0.0075
Echinococcus multilocularis geminin 0.1052 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.0283 0.0265
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0359 0.0918
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.3778 0.3767
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0148 0.013
Trypanosoma brucei unspecified product 0.0037 0.0119 0.0728
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0199 0.0181
Brugia malayi Pre-SET motif family protein 0.0062 0.0357 0.0914
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Loa Loa (eye worm) hypothetical protein 0.0149 0.1204 0.2467
Echinococcus granulosus aryl hydrocarbon receptor 0.0133 0.1048 0.1032
Onchocerca volvulus 0.0104 0.0771 0.1687
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0131 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus granulosus lysine specific demethylase 6a 0.0051 0.025 0.0232
Schistosoma mansoni fad oxidoreductase 0.0044 0.0184 0.0166
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0186
Onchocerca volvulus 0.0029 0.0039 0.0047
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0442 0.0905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.017 0.1089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0694 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0288
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0727 0.6836 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0336 0.0689
Loa Loa (eye worm) ACC-1 protein 0.0033 0.0075 0.0153
Plasmodium falciparum JmjC domain-containing protein, putative 0.0051 0.025 0.7028
Brugia malayi Muscleblind-like protein 0.0149 0.1204 0.3081
Brugia malayi hypothetical protein 0.0068 0.0422 0.1079
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0954 0.1954
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0044 0.0184 0.119
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.1013
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.4754
Loa Loa (eye worm) hypothetical protein 0.017 0.1411 0.2891
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0148 0.013
Echinococcus granulosus nAChR subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0044 0.0184 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0544 0.3778
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0563 0.0546
Schistosoma mansoni hypothetical protein 0.0413 0.3778 0.3767
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Brugia malayi PHD-finger family protein 0.0052 0.0265 0.0679
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.017 0.1411 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.0623
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Brugia malayi excitatory GABA receptor EXP-1A 0.0033 0.0075 0.0191
Echinococcus granulosus chromobox protein 1 0.007 0.0442 0.0424
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0304 0.0287
Schistosoma mansoni bromodomain containing protein 0.013 0.1024 0.1008
Trichomonas vaginalis set domain proteins, putative 0.0485 0.448 0.6544
Plasmodium vivax RNA helicase-1, putative 0.0053 0.0271 0.7226
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.0544 0.0772
Echinococcus multilocularis chromobox protein 1 0.007 0.0442 0.0424
Brugia malayi mbt repeat family protein 0.0049 0.0238 0.0608
Echinococcus multilocularis chromobox protein 1 0.007 0.0442 0.0424
Loa Loa (eye worm) ACC-1 protein 0.0033 0.0075 0.0153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0336 0.2131
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0148 0.0191
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0148 0.013
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.0283 0.0579
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0218 0.0201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Echinococcus granulosus jun protein 0.0087 0.0603 0.0586
Leishmania major DNA polymerase kappa, putative 0.0061 0.0348 0.2134
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0033 0.0075 0.0191
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0148 0.0191
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.0075 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0148 0.013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.036 0.2306
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0359 0.2216
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0131 0.6188
Loa Loa (eye worm) hypothetical protein 0.0096 0.0694 0.1423
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0138
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0313 0.2804 0.2791
Echinococcus granulosus dnaJ subfamily B 0.0413 0.3778 0.3767
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Echinococcus granulosus lamin dm0 0.0056 0.0307 0.0289
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Schistosoma mansoni alpha glucosidase 0.0036 0.0112 0.0094
Schistosoma mansoni alpha-glucosidase 0.0142 0.1135 0.112
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0044 0.0184 0.0166
Schistosoma mansoni phd/f-box containing protein 0.0051 0.025 0.0232
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0094 0.0076
Treponema pallidum fructose-bisphosphate aldolase 0.0727 0.6836 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0105 0.0128
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0094 0.0076
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0238 0.0487
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0562 0.0545
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0357 0.034
Leishmania major DNA polymerase eta, putative 0.008 0.0532 0.3502
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0033 0.0075 0.0057
Schistosoma mansoni single-minded 0.0061 0.0355 0.0337
Echinococcus granulosus zinc finger protein 0.0041 0.016 0.0142
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0053 0.0271 0.0253
Loa Loa (eye worm) hypothetical protein 0.0117 0.0893 0.1829
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.017 0.1411 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0825 0.0809
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.0283 0.0265
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0148 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0178 0.1491 0.1475
Onchocerca volvulus 0.0068 0.0422 0.0904
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Brugia malayi phosphofructokinase 0.011 0.0825 0.2112
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0033 0.0075 0.0153
Brugia malayi Bromodomain containing protein 0.0078 0.0514 0.1315
Plasmodium falciparum phd finger protein, putative 0.006 0.0336 1
Schistosoma mansoni d-amino acid oxidase 0.0526 0.4881 0.4871
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0053 0.0271 0.0253
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Schistosoma mansoni lamin 0.0056 0.0307 0.0289
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0544 0.059
Echinococcus granulosus intermediate filament protein 0.0056 0.0307 0.0289
Loa Loa (eye worm) hypothetical protein 0.0144 0.1155 0.2366
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0359 0.0341
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0307 0.0628
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0329 0.0312
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.0953 0.0937
Echinococcus granulosus single minded 2 0.0045 0.0199 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0348 0.2366
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0044 0.0184 0.0166
Onchocerca volvulus 0.0485 0.448 1
Trypanosoma brucei ISWI complex protein 0.0031 0.0059 0.0295
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0825 0.0809
Schistosoma mansoni intermediate filament proteins 0.0056 0.0307 0.0289
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0138
Brugia malayi Cation transporter family protein 0.0033 0.0075 0.0191
Echinococcus granulosus lamin 0.0056 0.0307 0.0289
Brugia malayi 6-phosphofructokinase 0.011 0.0825 0.2112
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0148 0.0379
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0238 0.022
Echinococcus granulosus nmda type glutamate receptor 0.0133 0.1052 0.1036
Plasmodium vivax SET domain protein, putative 0.0062 0.0357 1
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0044 0.0184 0.0186
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0044 0.0184 0.0243
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.0075 0.0057
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0428 0.0602
Brugia malayi cDNA sequence BC016226 0.0044 0.0184 0.047
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0563 0.0546
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0526 0.4881 0.5452
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.0075 0.0057
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0033 0.0075 0.0191
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0238 0.022
Echinococcus multilocularis expressed protein 0.0036 0.0105 0.0087
Chlamydia trachomatis glutamine binding protein 0.0038 0.0131 0.6188
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0085 0.058 0.1189
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0051 0.025 0.1498
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0141 0.0275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0044 0.0184 0.0371
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1689 0.1674
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0118
Loa Loa (eye worm) hypothetical protein 0.0132 0.1043 0.2137
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0825 0.0905
Leishmania major eukaryotic initiation factor 4a, putative 0.0053 0.0271 0.1566
Trypanosoma brucei DNA polymerase eta, putative 0.008 0.0532 0.3693
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0033 0.0075 0.0153
Loa Loa (eye worm) LGC-31 protein 0.0033 0.0075 0.0153
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0218 0.0201
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0336 0.0319
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0051 0.025 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Loa Loa (eye worm) hypothetical protein 0.0133 0.1057 0.2165
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0199 0.051
Onchocerca volvulus 0.0033 0.0075 0.0127
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0094 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0238 0.022
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0051 0.0131
Echinococcus granulosus jumonji domain containing 1A 0.0051 0.025 0.0232
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0238 0.022
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0482 0.4453 0.4973
Echinococcus granulosus phd:f box containing protein 0.0051 0.025 0.0232
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0033 0.0075 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0033 0.0075 0.0057
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0131 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0694 0.0678
Trypanosoma cruzi ISWI complex protein 0.0031 0.0059 0.0295
Loa Loa (eye worm) hypothetical protein 0.0078 0.0515 0.1056
Echinococcus granulosus cpg binding protein 0.0035 0.0093 0.0075
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0357 0.2284
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 1
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0359 0.0341
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0372
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0131 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0283 0.0724
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0532 0.1363
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0039 0.008
Echinococcus multilocularis phd:f box containing protein 0.0051 0.025 0.0232
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0825 0.0809
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0942 0.8937 1
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0825 0.0905
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0056 0.0304 0.0286
Trichomonas vaginalis rotamase, putative 0.0035 0.0097 0.0116
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0764 0.5261
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0148 0.0191
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.017 0.091
Brugia malayi intermediate filament protein 0.0056 0.0307 0.0784
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1689 0.1674
Schistosoma mansoni hypothetical protein 0.1052 1 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0153
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Leishmania major DNA polymerase eta, putative 0.0042 0.017 0.0818
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0304 0.0287
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0562 0.0545
Echinococcus granulosus microtubule associated protein 2 0.075 0.7063 0.7057
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0044 0.0184 0.047
Leishmania major hypothetical protein, conserved 0.0044 0.0184 0.0922
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0676
Brugia malayi jmjC domain containing protein 0.0195 0.166 0.4249
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0727 0.6836 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.017 0.034
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0112 0.023
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0764 0.0747
Echinococcus granulosus dna polymerase kappa 0.0081 0.0544 0.0527
Onchocerca volvulus 0.0073 0.0469 0.1012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0097 0.0116
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0033 0.0075 0.0057
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0097 0.0567
Onchocerca volvulus 0.0049 0.0238 0.0492
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0467 0.045
Mycobacterium ulcerans hypothetical protein 0.017 0.1411 0.1562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0033 0.0075 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0181 0.1173
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Giardia lamblia DINP protein human, muc B family 0.0061 0.0348 0.0445
Echinococcus multilocularis dna polymerase eta 0.008 0.0532 0.0515
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.166 0.1645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0377 0.036
Schistosoma mansoni zinc finger protein 0.0031 0.0059 0.0041
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Giardia lamblia PHD finger protein 15 0.006 0.0336 0.0429
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.0283 0.0265
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0044 0.0184 0.0186
Echinococcus granulosus dna polymerase eta 0.008 0.0532 0.0515
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0112 0.0138
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.4435
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.018
Echinococcus multilocularis lamin dm0 0.0056 0.0307 0.0289
Onchocerca volvulus 0.0056 0.0307 0.0647
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0283 0.0579
Schistosoma mansoni hypothetical protein 0.1052 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Echinococcus multilocularis jun protein 0.0087 0.0603 0.0586
Schistosoma mansoni cpg binding protein 0.0035 0.0093 0.0075
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0033 0.0075 0.0153
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0024
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0238 0.0492
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0112 0.0287
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0104 0.0771 0.0754
Trichomonas vaginalis chromobox protein, putative 0.0042 0.017 0.0223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0045
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0112 0.0138
Schistosoma mansoni NAD dehydrogenase 0.0044 0.0184 0.0166
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0044 0.0184 0.0243
Brugia malayi jmjC domain containing protein 0.0313 0.2804 0.7174
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0105 0.0269
Schistosoma mansoni zinc finger protein 0.0041 0.016 0.0142
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.0075 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.0283 0.0388
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0181 0.1173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0296 0.0607
Echinococcus granulosus glutamate receptor NMDA 0.008 0.0532 0.0515
Schistosoma mansoni rotamase 0.0036 0.0105 0.0087
Trichomonas vaginalis chromobox protein, putative 0.007 0.0442 0.0621
Brugia malayi chromobox protein homolog 3 0.0039 0.0141 0.036
Onchocerca volvulus 0.0031 0.0058 0.0089
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0304 0.0778
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0489
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0336 0.0319
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0044 0.0184 0.0166
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0112 0.0392
Brugia malayi Aldehyde dehydrogenase protein 4 0.0027 0.0018 0.0046
Chlamydia trachomatis D-amino acid dehydrogenase 0.0044 0.0184 1
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0336 0.2131
Brugia malayi polk-prov protein 0.0044 0.0181 0.0464
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0094 0.0076
Toxoplasma gondii hypothetical protein 0.0044 0.0184 0.1013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Echinococcus multilocularis lysine specific demethylase 5A 0.019 0.1606 0.1591
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0304 0.0287
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0106 0.0217
Schistosoma mansoni hypothetical protein 0.0071 0.0445 0.0428
Schistosoma mansoni lamin 0.0056 0.0307 0.0289
Brugia malayi eukaryotic initiation factor 4A 0.0053 0.0271 0.0693
Onchocerca volvulus 0.0056 0.0307 0.0647
Loa Loa (eye worm) hypothetical protein 0.0069 0.0428 0.0877
Echinococcus granulosus JmjC domain containing protein 4 0.0051 0.025 0.0232
Schistosoma mansoni chromobox protein 0.007 0.0442 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.017 0.1411 0.3611
Loa Loa (eye worm) hypothetical protein 0.0104 0.0771 0.1579
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0277 0.0259
Trypanosoma cruzi ISWI complex protein 0.0031 0.0059 0.0295
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0053 0.0271 0.0283
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0562 0.1438
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Echinococcus granulosus nmda type glutamate receptor 0.0087 0.0607 0.059
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0033 0.0075 0.0057
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0348 0.2134
Trichomonas vaginalis rotamase, putative 0.0036 0.0105 0.0128
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0287
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni hypothetical protein 0.0304 0.2718 0.2705
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0148 0.013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0116 0.0887 0.2271
Schistosoma mansoni fad oxidoreductase 0.0044 0.0184 0.0166
Brugia malayi 6-phosphofructokinase 0.011 0.0825 0.2112
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0022 0.0004
Echinococcus multilocularis nmda type glutamate receptor 0.0087 0.0607 0.059
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0112 0.0138
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0287
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0131 0.0126
Echinococcus multilocularis zinc finger protein 0.0041 0.016 0.0142
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0764 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0628
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0165 0.0337
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis JmjC domain containing protein 4 0.0051 0.025 0.0232
Echinococcus multilocularis muscleblind protein 0.0149 0.1204 0.1188
Schistosoma mansoni glutamate receptor NMDA 0.0102 0.0753 0.0736
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.0075 0.0191
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0056 0.0304 0.0286
Echinococcus multilocularis glutamate receptor NMDA 0.008 0.0532 0.0515
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.0544 0.0772
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0053 0.0271 0.0332
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0428 0.0411
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Plasmodium vivax hypothetical protein, conserved 0.006 0.0336 0.933
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0044 0.0184 0.047
Leishmania major hypothetical protein, conserved 0.0051 0.025 0.1412
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0148 0.013
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1204 0.1188
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0027 0.0018 0.0037
Echinococcus multilocularis nmda type glutamate receptor 0.0133 0.1052 0.1036
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Brugia malayi PHD-finger family protein 0.006 0.0336 0.0861
Onchocerca volvulus 0.0046 0.0204 0.0418
Onchocerca volvulus Putative fad oxidoreductase 0.0044 0.0184 0.0371
Schistosoma mansoni jumonji domain containing protein 0.0051 0.025 0.0232
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0033 0.0075 0.0057
Echinococcus granulosus expressed protein 0.0036 0.0105 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.075 0.7063 0.7057
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0336 0.0319
Plasmodium vivax JmjC domain containing protein 0.0051 0.025 0.6557
Brugia malayi Bromodomain containing protein 0.0154 0.1256 0.3213
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.0283 0.0265
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0825 0.1691
Onchocerca volvulus 0.0132 0.1043 0.2297
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0053 0.0271 0.0567
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Brugia malayi RE18450p 0.0044 0.0184 0.047
Schistosoma mansoni microtubule-associated protein tau 0.075 0.7063 0.7057
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0147
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0051 0.025 0.1498
Onchocerca volvulus 0.0104 0.0771 0.1687
Onchocerca volvulus Alhambra homolog 0.006 0.0336 0.0714
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0092 0.0235
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0603 0.0586
Echinococcus granulosus peregrin 0.0064 0.0383 0.0366
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0942 0.8937 1
Brugia malayi Cation transporter family protein 0.0033 0.0075 0.0191
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0825 0.1149
Echinococcus multilocularis peregrin 0.0064 0.0383 0.0366
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.0075 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0053 0.0271 0.1651
Echinococcus granulosus eukaryotic initiation factor 4A 0.0053 0.0271 0.0253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0038 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Onchocerca volvulus 0.0083 0.0562 0.1219
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0469 0.0452
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.0512
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1359 0.3477
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Schistosoma mansoni hypothetical protein 0.006 0.0336 0.0319
Schistosoma mansoni jumonji domain containing protein 0.0273 0.2413 0.24
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0544 0.059
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0057
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0033 0.0075 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Onchocerca volvulus Putative nachr subunit 0.0033 0.0075 0.0127
Onchocerca volvulus 0.0033 0.0075 0.0127
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0825 0.5796
Trichomonas vaginalis chromobox protein, putative 0.007 0.0442 0.0621
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0942 0.8937 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0238 0.022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0051 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0479 0.3312
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0044 0.0184 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0825 0.1691
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.166 0.1645
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0487
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0825 0.0809
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0532 0.3693
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0336 0.0689
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0044 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Brugia malayi mbt repeat family protein 0.0049 0.0238 0.0608
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0676
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.3908 0.8007
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0376
Loa Loa (eye worm) hypothetical protein 0.0149 0.1204 0.2467
Trypanosoma brucei unspecified product 0.0074 0.0479 0.3312
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0694 0.0678
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0825 0.0905
Loa Loa (eye worm) hypothetical protein 0.0526 0.4881 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Brugia malayi Bromodomain containing protein 0.0064 0.0383 0.0981
Schistosoma mansoni alpha-glucosidase 0.0142 0.1135 0.112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0283 0.0297
Schistosoma mansoni cpg binding protein 0.0035 0.0093 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0199 0.0203
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0307 0.0628
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0053 0.0271 0.0253
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0825 0.5796
Loa Loa (eye worm) hypothetical protein 0.0104 0.0771 0.1579
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Echinococcus granulosus lysine specific demethylase 5A 0.0195 0.166 0.1645
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0544 0.3778
Brugia malayi Cation transporter family protein 0.0104 0.0771 0.1972
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0238 0.022
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0044 0.0184 0.0922
Echinococcus multilocularis musashi 0.0056 0.0307 0.0289
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0044 0.0184 0.0371
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0022 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.0051 0.025 0.0232
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0104 0.0771 0.0754
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.0512
Brugia malayi Melibiase family protein 0.0069 0.0428 0.1096
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Giardia lamblia Fructose-bisphosphate aldolase 0.0727 0.6836 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0148 0.0659
Schistosoma mansoni cpg binding protein 0.0029 0.0039 0.0021
Leishmania major eukaryotic initiation factor 4a, putative 0.0053 0.0271 0.1566
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0428 0.0411
Schistosoma mansoni hypothetical protein 0.0031 0.0059 0.0041
Loa Loa (eye worm) hypothetical protein 0.0083 0.0562 0.1152
Loa Loa (eye worm) hypothetical protein 0.0089 0.0624 0.1278
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0238 0.022
Onchocerca volvulus 0.0033 0.0075 0.0127
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0097 0.0567
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Loa Loa (eye worm) hypothetical protein 0.0083 0.0562 0.1152
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0313 0.2804 0.2791
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1359 0.2784
Trichomonas vaginalis chromobox protein, putative 0.0042 0.017 0.0223
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0033 0.0075 0.0191
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0825 0.5669
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0033 0.0075 0.0191
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.0075 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.0953 0.0937
Loa Loa (eye worm) phosphofructokinase 0.011 0.0825 0.1691
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0357 0.034
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) MBCTL1 0.0056 0.0304 0.0623
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0133 0.1048 0.1032
Echinococcus granulosus muscleblind protein 0.0149 0.1204 0.1188
Echinococcus granulosus chromobox protein 1 0.007 0.0442 0.0424
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Leishmania major hypothetical protein, conserved 0.0044 0.0184 0.0922
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0053 0.0271 0.0253
Echinococcus multilocularis lysine specific demethylase 6a 0.0051 0.025 0.0232
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.0075 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0467 0.045
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Onchocerca volvulus 0.0104 0.0771 0.1687
Loa Loa (eye worm) jmjC domain-containing protein 0.0195 0.166 0.3402
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0097 0.0567
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0053 0.0271 0.0371
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0148 0.0191
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.004 0.0148 0.0304
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0562 0.0545
Echinococcus multilocularis nAChR subunit 0.0033 0.0075 0.0057
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Loa Loa (eye worm) hypothetical protein 0.0088 0.0616 0.1262
Trypanosoma brucei glucosidase, putative 0.0036 0.0112 0.0676
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0033 0.0075 0.0057
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0033 0.0075 0.0191
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis lamin 0.0056 0.0307 0.0289
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni DNA polymerase eta 0.008 0.0532 0.0515
Brugia malayi Pre-SET motif family protein 0.0426 0.3908 1
Echinococcus multilocularis dna polymerase kappa 0.0081 0.0544 0.0527
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0033 0.0075 0.0057
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0105 0.0216
Onchocerca volvulus 0.0095 0.0683 0.1491
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0694 0.0678
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0097 0.028
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0526 0.4881 0.5452
Treponema pallidum ATP-dependent RNA helicase 0.0053 0.0271 0.0332
Plasmodium falciparum eukaryotic initiation factor 4A 0.0053 0.0271 0.7746
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0112 0.0094
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0033 0.0075 0.0191
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0097 0.0378
Loa Loa (eye worm) hypothetical protein 0.0053 0.0271 0.0555
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0148 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0053 0.0271 0.0253
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0348 0.037
Echinococcus multilocularis jumonji domain containing 1A 0.0051 0.025 0.0232
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.0075 0.0057
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0764 0.0747
Brugia malayi PAS domain containing protein 0.0061 0.0355 0.0907
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0603 0.0586
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0359 0.0341
Schistosoma mansoni protein phosphatase 2C 0.0051 0.025 0.0232
Entamoeba histolytica steroid 5-alpha reductase, putative 0.017 0.1411 0.2043
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0204
Brugia malayi bZIP transcription factor family protein 0.0087 0.0603 0.1544
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.017 0.1411 1
Brugia malayi Heterochromatin protein 1 0.007 0.0442 0.113
Schistosoma mansoni jun-related protein 0.0071 0.0445 0.0428
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0112 0.0094
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0218 0.0201
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0148 0.013
Loa Loa (eye worm) hypothetical protein 0.008 0.0532 0.1091
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0112 0.0138
Schistosoma mansoni chromobox protein 0.007 0.0442 0.0424
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0307 0.0784
Trypanosoma brucei unspecified product 0.0037 0.0119 0.0728
Brugia malayi CXXC zinc finger family protein 0.0029 0.0039 0.01

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 557 uM Cytotoxic dose in MT-4 cells ChEMBL. 2754700
CD50 (functional) = 557 uM Cytotoxicity was determined as the dose required to reduce the viability of uninfected MT-4 cells by 50% ChEMBL. 3499515
CD50 (functional) > 625 uM Cytotoxicity was determined as the dose required to reduce the viability of uninfected MT-4 cells by 50% ChEMBL. 3499515
ED50 (functional) = 50 uM Inhibitory activity against HIV-1 replication in MT-4 cells ChEMBL. 2754700
ED50 (functional) = 50 uM Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction ChEMBL. 3499515
ED50 (functional) = 221 uM Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction ChEMBL. 3499515
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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