Detailed information for compound 942722

Basic information

Technical information
  • TDR Targets ID: 942722
  • Name: (6R)-3-(acetyloxymethyl)-7-ethenylidene-5,5,8 -trioxo-5$l^{6}-thia-1-azabicyclo[4.2.0]oct-2 -ene-2-carboxylic acid
  • MW: 313.283 | Formula: C12H11NO7S
  • H donors: 1 H acceptors: 6 LogP: -2.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C=C1C(=O)N2[C@@H]1S(=O)(=O)CC(=C2C(=O)O)COC(=O)C
  • InChi: 1S/C12H11NO7S/c1-3-8-10(15)13-9(12(16)17)7(4-20-6(2)14)5-21(18,19)11(8)13/h11H,1,4-5H2,2H3,(H,16,17)/t11-/m1/s1
  • InChiKey: ZLYQUOKXGNQRIC-LLVKDONJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6R)-3-(acetoxymethyl)-5,5,8-trioxo-7-vinylidene-5$l^{6}-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R)-3-(acetoxymethyl)-5,5,8-triketo-7-vinylidene-5$l^{6}-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0325 0.049
Echinococcus granulosus solute carrier family 22 0.001 0.0008 0.0013
Brugia malayi EGF-like domain containing protein 0.0008 0.0000000053827 0.000000061092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0023
Loa Loa (eye worm) cytochrome P450 0.0014 0.0037 0.0415
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0002 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0037 0.3322
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0325 0.1445
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Onchocerca volvulus 0.0104 0.0624 1
Echinococcus granulosus solute carrier family 22 0.001 0.0008 0.0013
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0184 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.3315
Echinococcus granulosus bloom syndrome protein 0.0021 0.0083 0.0125
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0184 0.0184
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0072 0.0322
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0019 0.059
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0008 0.0096
Schistosoma mansoni sugar transporter 0.001 0.0008 0.0008
Brugia malayi hypothetical protein 0.0104 0.0624 0.7084
Echinococcus multilocularis Ankyrin 0.0014 0.0039 0.0172
Toxoplasma gondii MAPEG family protein 0.0353 0.2249 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0057
Onchocerca volvulus 0.001 0.0008 0.0135
Brugia malayi jmjC domain containing protein 0.0058 0.0325 0.3688
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0002 0.0103
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0037 0.0163
Schistosoma mansoni peroxidasin 0.0104 0.0624 0.0624
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0019 0.059
Schistosoma mansoni DNA helicase recq1 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0037 0.3322
Brugia malayi notch-like transmembrane receptor 0.0008 0.0000000053827 0.000000061092
Echinococcus multilocularis solute carrier family 22 0.001 0.0008 0.0037
Loa Loa (eye worm) sugar transporter 0.001 0.0008 0.0096
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0037 0.3322
Brugia malayi Death domain containing protein 0.0014 0.0038 0.0431
Schistosoma mansoni sugar transporter 0.001 0.0008 0.0008
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0037 0.3322
Onchocerca volvulus 0.001 0.0008 0.0135
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0184 0.8281
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0184 0.2088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0527
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Onchocerca volvulus 0.001 0.0008 0.0135
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0325 0.0325
Schistosoma mansoni sugar transporter 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0072 0.0322
Echinococcus multilocularis RUN 0.002 0.0072 0.0322
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0093 1
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0624 0.7084
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0823
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0093 0.1057
Echinococcus granulosus death domain containing protein 0.0014 0.0038 0.0057
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0624 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0083 0.3516
Brugia malayi Cytochrome P450 family protein 0.0023 0.0093 0.1057
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0038 0.1411
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0046 0.2166
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0325 0.049
Schistosoma mansoni peroxidasin 0.0104 0.0624 0.0624
Echinococcus multilocularis solute carrier family 22 0.001 0.0008 0.0037
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0046 0.007
Onchocerca volvulus 0.001 0.0008 0.0135
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0037 0.3322
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0046 0.0046
Brugia malayi Sugar transporter family protein 0.001 0.0008 0.0096
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0855 0.1289
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0037 0.1604
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Schistosoma mansoni hypothetical protein 0.0168 0.1039 0.1039
Toxoplasma gondii sugar transporter ST1 0.001 0.0008 0.0037
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0037 0.3322
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0184 0.9244
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.022 0.098
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0037 0.1604
Brugia malayi jmjC domain containing protein 0.0016 0.0046 0.0527
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Schistosoma mansoni microsomal glutathione s-transferase 0.0353 0.2249 0.2249
Plasmodium falciparum hexose transporter 0.001 0.0008 0.0326
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0039 0.0039
Brugia malayi Cytochrome P450 family protein 0.0052 0.0283 0.3212
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0037 0.4838
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0008 0.0013
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0093 0.4827
Brugia malayi Blistered cuticle protein 3 0.0104 0.0624 0.7084
Onchocerca volvulus Dual oxidase homolog 0.0104 0.0624 1
Brugia malayi hypothetical protein 0.002 0.0072 0.0823
Onchocerca volvulus Neurogenic locus notch homolog 0.0009 0.0001 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0009
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0002 0.0009
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0038 0.0169
Onchocerca volvulus Chorion peroxidase homolog 0.0104 0.0624 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0008 0.0037
Brugia malayi Protein kinase domain containing protein 0.0014 0.0038 0.0431
Onchocerca volvulus 0.001 0.0008 0.0135
Brugia malayi jmjC domain containing protein 0.0016 0.0046 0.0527
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0046 0.2166
Schistosoma mansoni polycystin 1-related 0.002 0.0072 0.0072
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0046 0.0046
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0046 0.0206
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0197 1
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0000000053827 0.0000000081196
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0184 0.9316
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0624 0.7084
Schistosoma mansoni hypothetical protein 0.0168 0.1039 0.1039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0184 0.8281
Leishmania major cytochrome p450-like protein 0.0014 0.0037 0.1604
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0184 0.0277
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0527
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0325 0.3688
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0008 0.0037
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0046 0.0206
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0046 0.0046
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0037 0.4838
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0037 0.1604
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0037 0.1604
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0008 0.0013
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0037 0.3322
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0037 0.4838
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0184 0.0818
Onchocerca volvulus 0.001 0.0008 0.0135
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.2745
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0037 0.4838
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.022 1
Echinococcus granulosus peroxidasin 0.0104 0.0624 0.0942
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.3315
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0302 0.0455
Brugia malayi cytochrome P450 0.0014 0.0037 0.0415
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0083 0.0941
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0046 0.0527
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0008 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0046 0.0527
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0046 0.0206
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0037 0.3322
Onchocerca volvulus 0.001 0.0008 0.0135
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0823
Schistosoma mansoni glucose transport protein 0.001 0.0008 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0037 0.4838
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0037 0.4838
Onchocerca volvulus Peroxidase homolog 0.0104 0.0624 1
Echinococcus granulosus geminin 0.0168 0.1039 0.1568
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0008 0.0013
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0037 0.3322
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0184 1
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0046 0.007
Onchocerca volvulus 0.001 0.0008 0.0135
Leishmania major cytochrome p450-like protein 0.0023 0.0093 0.4827
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0037 0.4838
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0037 0.3322
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0046 0.0206
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0008 0.0096
Brugia malayi hypothetical protein 0.001 0.0008 0.0096
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0037 0.3322
Schistosoma mansoni loxhd1 0.002 0.0072 0.0072
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0037 0.4838
Schistosoma mansoni glucose transport protein 0.001 0.0008 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0002 0.0009
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0037 0.3322
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0067
Schistosoma mansoni rab6-interacting 0.002 0.0072 0.0072
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0002 0.0023
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0037 0.3322
Schistosoma mansoni cytochrome P450 0.0014 0.0037 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0093 0.4827
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0072 0.3022
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0038 0.0038
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0019 0.0488
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0083 0.3516
Schistosoma mansoni hypothetical protein 0.0014 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0037 0.4838
Toxoplasma gondii sugar transporter ST3 0.001 0.0008 0.0037
Echinococcus multilocularis peroxidasin 0.0104 0.0624 0.2775
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.022 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0046 0.0046
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0072 0.0109
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0046 0.0046
Loa Loa (eye worm) doublecortin family protein 0.002 0.0072 0.0823
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0037 0.3322
Echinococcus granulosus Solute carrier family 22 5 0.1024 0.6629 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Schistosoma mansoni notch 0.0009 0.0001 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0067 0.0296
Onchocerca volvulus 0.001 0.0008 0.0135
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0046 0.0206
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0527
Echinococcus granulosus RUN 0.002 0.0072 0.0109
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0008 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0067 0.3315
Schistosoma mansoni glucose transport protein 0.001 0.0008 0.0008
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0184 0.0277
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0046 0.0206
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0325 0.0325
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0184 0.0277
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0421 0.0635
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0067 0.0756
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0000000053827 0.000000086237
Schistosoma mansoni sugar transporter 0.001 0.0008 0.0008
Brugia malayi major facilitator superfamily protein 0.001 0.0008 0.0096
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0046 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0067 0.6867
Onchocerca volvulus 0.001 0.0008 0.0135
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0881 0.3917
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0037 0.3322
Schistosoma mansoni glucose transporter 0.001 0.0008 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0037 0.0165
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0008 0.0013
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0197 1
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0353 0.2249 1
Schistosoma mansoni netrin receptor unc5 0.0014 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.002 0.0072 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0037 0.4838
Echinococcus granulosus solute carrier family 22 0.001 0.0008 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0046 0.0527
Plasmodium vivax JmjC domain containing protein 0.0016 0.0046 0.1793
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0431
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0625
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0002 0.0003
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0624 0.7084
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Schistosoma mansoni hypothetical protein 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0184 0.8281
Echinococcus granulosus phd:f box containing protein 0.0016 0.0046 0.007
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0093 0.4827
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0037 0.4838
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0067 0.2677
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0037 0.4838
Loa Loa (eye worm) sugar transporter 0.001 0.0008 0.0096
Leishmania major cytochrome p450-like protein 0.0014 0.0037 0.1604
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0046 0.2166
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0038 0.0057
Loa Loa (eye worm) RecQ helicase 0.0021 0.0083 0.0941
Brugia malayi Doublecortin family protein 0.002 0.0072 0.0823
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0008 0.0096
Onchocerca volvulus 0.001 0.0008 0.0135
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0037 0.1604
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0008 0.0096
Echinococcus multilocularis 0.0014 0.0037 0.0163
Leishmania major hypothetical protein, conserved 0.0016 0.0046 0.2166
Toxoplasma gondii exonuclease III APE 0.0019 0.0067 0.0296
Onchocerca volvulus Putative transporter 0.001 0.0008 0.0135
Brugia malayi jmjC domain containing protein 0.0016 0.0046 0.0527
Schistosoma mansoni lipoxygenase 0.002 0.0072 0.0072
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Onchocerca volvulus 0.001 0.0008 0.0135
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0624 0.7084
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0037 0.4838
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0067 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0046 0.2272
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0184 0.0818
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0008 0.0037
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0624 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0184 0.0818
Echinococcus multilocularis solute carrier family 22 0.001 0.0008 0.0037
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0008 0.0037
Brugia malayi Cytochrome P450 family protein 0.0014 0.0037 0.0415
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0072 0.0109
Brugia malayi Sugar transporter family protein 0.001 0.0008 0.0096
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0046 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0000000053827 0.00000002393
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.022 0.0332
Brugia malayi Cytochrome P450 family protein 0.0023 0.0093 0.1057
Onchocerca volvulus 0.001 0.0008 0.0135
Schistosoma mansoni rab6-interacting 0.002 0.0072 0.0072
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0037 0.3322
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 1
Onchocerca volvulus 0.002 0.0072 0.1161
Loa Loa (eye worm) blistered cuticle protein 3 0.0104 0.0624 0.7084
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0037 0.4838
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Giardia lamblia Hexose transporter 0.001 0.0008 0.0426
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0072 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0037 0.4838
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.022 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.022 0.098
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0038 0.0431
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.2745
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0067 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.2088
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0066 0.3284
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0037 0.3322
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0037 0.4838
Brugia malayi Uncoordinated protein 44 0.0014 0.0038 0.0431
Mycobacterium leprae putative cytochrome p450 0.0014 0.0037 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0302 0.1341
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0008 0.0013
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0008 0.0037
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0038 0.0431
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0067 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0037 0.4838
Onchocerca volvulus 0.0104 0.0624 1
Schistosoma mansoni DNA helicase recq5 0.0009 0.0002 0.0002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0421 0.187
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0008 0.0008
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0038 0.0609
Onchocerca volvulus Peroxidase homolog 0.0104 0.0624 1
Brugia malayi Peroxidasin 0.0104 0.0624 0.7084
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.3304
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0067 0.3315
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0072 0.3604
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0325 0.1445
Onchocerca volvulus 0.001 0.0008 0.0135
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0624 0.7084
Onchocerca volvulus 0.001 0.0008 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0283 0.3212
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0038 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0037 0.4838
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0624 0.7084
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0624 0.7084
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0067 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0037 0.4838
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.044
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0197 1
Echinococcus multilocularis solute carrier family 22 0.001 0.0008 0.0037
Brugia malayi hypothetical protein 0.001 0.0008 0.0096
Onchocerca volvulus 0.0104 0.0624 1
Brugia malayi major facilitator superfamily protein 0.001 0.0008 0.0096
Toxoplasma gondii sugar transporter ST2 0.001 0.0008 0.0037
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0000000053827 0.000000061092
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0067 0.3373
Brugia malayi jmjC domain containing protein 0.0016 0.0046 0.0527
Brugia malayi hypothetical protein 0.001 0.0008 0.0096
Echinococcus granulosus Ankyrin 0.0014 0.0039 0.0058
Giardia lamblia Sugar-proton symporter 0.001 0.0008 0.0426
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0037 0.3322
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0067 0.0756
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0046 0.0206
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0624 0.7084
Schistosoma mansoni lipoxygenase 0.0055 0.0302 0.0302
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0083 0.0369
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0008 0.0326
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0624 0.7084
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0093 0.1057
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0037 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0093 0.1057
Onchocerca volvulus 0.001 0.0008 0.0135
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0037 0.4838
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0325 0.0325
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.2745
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0019 0.059
Brugia malayi jmjC domain containing protein 0.0058 0.0325 0.3688
Onchocerca volvulus 0.002 0.0072 0.1161
Schistosoma mansoni hypothetical protein 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0104 0.0624 0.7084
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0037 0.3322
Echinococcus granulosus microsomal glutathione S transferase 3 0.0353 0.2249 0.3393
Echinococcus multilocularis geminin 0.0168 0.1039 0.4621
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0096
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0037 0.3322
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0023
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0008 0.0037
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0072 0.0322
Loa Loa (eye worm) acetyltransferase 0.0143 0.0881 1
Brugia malayi Sugar transporter family protein 0.001 0.0008 0.0096
Brugia malayi hypothetical protein 0.002 0.0072 0.0823
Echinococcus granulosus solute carrier family 22 0.001 0.0008 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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