pI: 5.2261 |
Length (AA): 523 |
MW (Da): 54683 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
222 | 500 | 1inl (A) | 7 | 290 | 23.00 | 0 | 1 | 0.761561 | -0.12 |
223 | 500 | 2o06 (A) | 10 | 295 | 26.00 | 0 | 1 | 0.856649 | -0.66 |
258 | 471 | 2hte (B) | 31 | 244 | 35.00 | 0 | 1 | 0.709078 | -0.47 |
288 | 506 | 2i7c (A) | 63 | 282 | 25.00 | 0.022 | 1 | 0.768538 | -0.9 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase, Dormant phase. | hasan murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127074)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G23820 | spermidine synthase 1 |
Arabidopsis thaliana | AT1G70310 | Spermidine synthase 2 |
Arabidopsis thaliana | AT5G19530 | Thermospermine synthase ACAULIS5 |
Brugia malayi | Bm1_44015 | Spermidine synthase |
Candida albicans | CaO19.2250 | spermidine synthase |
Candida albicans | CaO19.9790 | spermidine synthase |
Caenorhabditis elegans | CELE_Y46G5A.19 | Protein SPDS-1, isoform B |
Dictyostelium discoideum | DDB_G0268630 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8327 | Spermidine Synthase |
Escherichia coli | b0121 | spermidine synthase (putrescine aminopropyltransferase) |
Echinococcus granulosus | EgrG_000485300 | spermidine synthase |
Echinococcus multilocularis | EmuJ_000485300 | spermidine synthase |
Homo sapiens | ENSG00000116649 | spermidine synthase |
Leishmania braziliensis | LbrM.04.0630 | spermidine synthase, putative |
Leishmania donovani | LdBPK_040570.1 | spermidine synthase, putative |
Leishmania infantum | LinJ.04.0570 | spermidine synthase, putative |
Leishmania major | LmjF.04.0580 | spermidine synthase |
Leishmania mexicana | LmxM.04.0580 | spermidine synthase, putative |
Loa Loa (eye worm) | LOAG_01004 | spermidine synthase |
Mus musculus | ENSMUSG00000006442 | spermidine synthase |
Mycobacterium tuberculosis | Rv2601 | Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) |
Mycobacterium ulcerans | MUL_1708 | spermidine synthase |
Oryza sativa | 4328835 | Os02g0237100 |
Oryza sativa | 4342996 | Os07g0408700 |
Plasmodium berghei | PBANKA_0919300 | spermidine synthase, putative |
Plasmodium falciparum | PF3D7_1129000 | spermidine synthase |
Plasmodium knowlesi | PKNH_0927000 | spermidine synthase, putative |
Plasmodium vivax | PVX_092065 | spermidine synthase, putative |
Plasmodium yoelii | PY04977 | spermidine synthase-related |
Saccharomyces cerevisiae | YLR146C | spermine synthase |
Saccharomyces cerevisiae | YPR069C | spermidine synthase |
Schmidtea mediterranea | mk4.005944.00 | Spermidine synthase |
Schmidtea mediterranea | mk4.000519.03 | Spermidine synthase |
Schmidtea mediterranea | mk4.010072.02 | Spermidine synthase |
Trypanosoma brucei gambiense | Tbg972.9.4260 | spermidine synthase, putative |
Trypanosoma brucei | Tb927.9.7770 | spermidine synthase |
Trypanosoma congolense | TcIL3000_9_2680 | spermidine synthase |
Trypanosoma cruzi | TcCLB.504033.130 | spermidine synthase, putative |
Trypanosoma cruzi | TcCLB.510339.50 | spermidine synthase, putative |
Trypanosoma cruzi | TcCLB.510337.40 | spermidine synthase, putative |
Trypanosoma cruzi | TcCLB.503855.20 | spermidine synthase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2645 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb09.v1.0380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.v1.0380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.v1.0380 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.v1.0380 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0121 | Escherichia coli | non-essential | goodall |
PBANKA_0919300 | Plasmodium berghei | Essential | plasmo |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | spermidine synthase | Compounds | References |
Trypanosoma cruzi | spermidine synthase, putative | Compounds | References |
Rattus norvegicus | Spermidine synthase | Compounds | References |
Sus scrofa | Spermidine synthase | Compounds | References |
Plasmodium falciparum | spermidine synthase | Compounds | References |
2 literature references were collected for this gene.