Detailed information for compound 1015768

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.517 | Formula: C21H32N6O4
  • H donors: 5 H acceptors: 6 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NC1CCCCC1)nc2NC1CCCC1
  • InChi: 1S/C21H32N6O4/c28-10-14-16(29)17(30)20(31-14)27-11-22-15-18(23-12-8-4-5-9-12)25-21(26-19(15)27)24-13-6-2-1-3-7-13/h11-14,16-17,20,28-30H,1-10H2,(H2,23,24,25,26)/t14-,16-,17-,20-/m1/s1
  • InChiKey: JKIBJPQLGMADCS-WVSUBDOOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0026 0.0012
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0197 0.0507 0.5149
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0051 0.0453
Entamoeba histolytica hypothetical protein 0.008 0.0158 0.3116
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0026 0.0139
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0148 0.0362 0.0348
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0206 0.0534 0.116
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Onchocerca volvulus Peroxidasin homolog 0.0138 0.0332 0.2141
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0057 0.0096
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0361 0.116
Echinococcus granulosus GPCR family 2 0.0052 0.0076 0.0138
Plasmodium vivax thioredoxin reductase, putative 0.0205 0.0531 0.5394
Schistosoma mansoni hypothetical protein 0.0535 0.1508 0.3336
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0051 0.0534
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0036 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0468 0.1311 0.4711
Leishmania major cysteine peptidase A (CPA) 0.0039 0.0037 0.0387
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0715
Brugia malayi ImpB/MucB/SamB family protein 0.0071 0.0133 0.096
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.0133 0.1397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Loa Loa (eye worm) carboxylesterase 0.0066 0.0118 0.0844
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0046 0.031
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0071 0.0133 0.1402
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0123 0.0286 0.2058
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0046 0.0033
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0197 0.0507 0.534
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0077 0.0532
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0036 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.014 0.1015
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0037 0.0153
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0107 0.2102
Onchocerca volvulus 0.00552502 0.5 0.5
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0468 0.1311 0.6793
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0041 0.0043 0.0064
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0036 0.005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0036 0.0218
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0107 0.0207
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0046 0.031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0158 0.0322
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Leishmania major mitochondrial DNA polymerase beta 0.0346 0.095 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Mycobacterium ulcerans fatty-acid-CoA ligase 0.006 0.0101 0.0279
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0057 0.0043
Trichomonas vaginalis rotamase, putative 0.0038 0.0034 0.0229
Echinococcus multilocularis Immunoglobulin 0.0041 0.0043 0.0029
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0026 0.0027
Onchocerca volvulus 0.0148 0.0361 0.2337
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0254 0.189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Trypanosoma cruzi trypanothione reductase, putative 0.0205 0.0531 0.559
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0123 0.0286 0.2865
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0107 0.1047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0036 0.0218
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0107 0.0759
Loa Loa (eye worm) fibroinase 0.0039 0.0037 0.0221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Echinococcus granulosus phd:f box containing protein 0.0035 0.0026 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0037 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0107 0.0209
Plasmodium vivax SET domain protein, putative 0.0067 0.0121 0.1165
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Schistosoma mansoni tar DNA-binding protein 0.0073 0.014 0.0281
Plasmodium vivax acyl-CoA synthetase, putative 0.006 0.0101 0.0959
Entamoeba histolytica hypothetical protein 0.008 0.0158 0.3116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0121 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0037 0.0221
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0081 0.0161 0.0614
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0107 0.1122
Echinococcus multilocularis neuroglian 0.0041 0.0043 0.0029
Echinococcus multilocularis phosphoglycerate kinase 1 0.0197 0.0507 0.0494
Echinococcus granulosus peroxidasin 0.0151 0.0371 0.0798
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0046 0.031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0133 0.1402
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.006 0.0101 0.0188
Plasmodium vivax vivapain-2 0.0039 0.0037 0.0297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0051 0.0534
Toxoplasma gondii exonuclease III APE 0.0062 0.0107 0.1017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0036 0.005
Leishmania major DNA polymerase kappa, putative 0.0043 0.0051 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Schistosoma mansoni microtubule-associated protein tau 0.1541 0.4493 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0051 0.0534
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0051 0.0338
Schistosoma mansoni alpha-glucosidase 0.0163 0.0404 0.0871
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0409 0.4301
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0107 0.0759
Onchocerca volvulus Dual oxidase homolog 0.00552502 0.5 0.5
Echinococcus granulosus neuroglian 0.0041 0.0043 0.0064
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0026 0.0187
Onchocerca volvulus Peroxidase homolog 0.00552502 0.5 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0294 0.0795 0.0783
Mycobacterium ulcerans phosphoglycerate kinase 0.0197 0.0507 0.2532
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0057 0.0599
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0043 0.0029
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0233 0.0614 0.2106
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0206 0.0534 0.3498
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0233 0.0614 0.2106
Leishmania major DNA polymerase eta, putative 0.0041 0.0044 0.0465
Onchocerca volvulus 0.0148 0.0361 0.2337
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0078
Loa Loa (eye worm) prolyl oligopeptidase 0.0206 0.0534 0.4043
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0037 0.0223
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.0161 0.17
Brugia malayi Animal haem peroxidase family protein 0.00552502 0.5 0.5
Schistosoma mansoni peptidase Clp (S14 family) 0.0356 0.0978 0.2152
Leishmania major trypanothione reductase 0.0205 0.0531 0.559
Mycobacterium ulcerans lipase LipD 0.0148 0.0361 0.1721
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0036 0.005
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0197 0.0507 0.2043
Leishmania major cathepsin L-like protease 0.0039 0.0037 0.0387
Schistosoma mansoni peroxidasin 0.00552502 0.5 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0164 0.0409 0.4253
Entamoeba histolytica hypothetical protein 0.008 0.0158 0.3116
Loa Loa (eye worm) animal heme peroxidase 0.0138 0.0332 0.2492
Echinococcus multilocularis Immunoglobulin 0.0041 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0131 0.0445
Brugia malayi Animal haem peroxidase family protein 0.0138 0.0332 0.2492
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0069 0.0128 0.1235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0036 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.052 0.1466 0.529
Onchocerca volvulus 0.0138 0.0332 0.2141
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0071 0.0133 0.1291
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0069 0.0128 0.1345
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0361 0.3801
Echinococcus granulosus snurportin 1 0.0345 0.0946 0.2081
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0356 0.0978 0.0965
Brugia malayi Peroxidasin 0.0151 0.0371 0.2794
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0128 0.0921
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0091 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0107 0.0711
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0071 0.0133 0.0266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0407 0.307
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0071 0.0133 0.0367
Mycobacterium leprae Probable lipase LipE 0.0148 0.0361 0.118
Brugia malayi beta-lactamase 0.0148 0.0361 0.2716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.0473 0.309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Schistosoma mansoni jumonji domain containing protein 0.0131 0.0312 0.0665
Brugia malayi nuclear hormone receptor 0.0038 0.0036 0.0218
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0312 0.0665
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0361 0.3801
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0044 0.0373
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0356 0.0978 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0118 0.0844
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0076 0.052
Schistosoma mansoni hypothetical protein 0.0052 0.0076 0.0138
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0188 0.371
Entamoeba histolytica phosphoglycerate kinase, putative 0.0197 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0026 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0123 0.0286 0.2865
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0206 0.0534 0.116
Schistosoma mansoni hypothetical protein 0.0112 0.0254 0.0535
Loa Loa (eye worm) animal heme peroxidase 0.00552502 0.5 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Brugia malayi Animal haem peroxidase family protein 0.0138 0.0332 0.2492
Echinococcus multilocularis expressed protein 0.0039 0.0037 0.0023
Schistosoma mansoni phosphoglycerate kinase 0.0197 0.0507 0.1101
Onchocerca volvulus Dual oxidase homolog 0.0138 0.0332 0.2141
Toxoplasma gondii hypothetical protein 0.0123 0.0286 0.2865
Trypanosoma brucei unspecified product 0.003 0.0011 0.003
Toxoplasma gondii cathepsin CPL 0.0039 0.0037 0.0297
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0026 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0036 0.0218
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0018 0.0108
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0139
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0197 0.0507 0.5149
Brugia malayi Animal haem peroxidase family protein 0.00552502 0.5 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.0161 0.3183
Onchocerca volvulus 0.0055 0.0086 0.0486
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0071 0.0133 0.1291
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0026 0.0012
Trypanosoma brucei phosphoglycerate kinase 0.0197 0.0507 0.53
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Loa Loa (eye worm) hypothetical protein 0.0066 0.0118 0.0844
Brugia malayi Pre-SET motif family protein 0.0467 0.1308 1
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0086 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0036 0.0022
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0651 0.1854 0.6739
Leishmania major hypothetical protein, conserved 0.0029 0.0008 0.0084
Loa Loa (eye worm) hypothetical protein 0.0067 0.0121 0.0869
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0036 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0051 0.0534
Mycobacterium ulcerans hypothetical protein 0.0081 0.0161 0.0614
Brugia malayi Thioredoxin reductase 0.0205 0.0531 0.4024
Schistosoma mansoni peroxidasin 0.00552502 0.5 0.5
Brugia malayi jmjC domain containing protein 0.0035 0.0026 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0073 0.014 0.0281
Schistosoma mansoni hypothetical protein 0.0349 0.0956 0.2104
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0715
Giardia lamblia Phosphoglycerate kinase 0.0197 0.0507 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0109 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Brugia malayi ecdysteroid receptor 0.0038 0.0036 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Chlamydia trachomatis phosphoglycerate kinase 0.0197 0.0507 0.4634
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0133 0.0305
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Trypanosoma brucei phosphoglycerate kinase, putative 0.0072 0.0137 0.1369
Loa Loa (eye worm) animal heme peroxidase 0.0138 0.0332 0.2492
Brugia malayi Carboxylesterase family protein 0.0066 0.0118 0.0844
Schistosoma mansoni tar DNA-binding protein 0.0073 0.014 0.0281
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0071 0.0133 0.0119
Brugia malayi Pre-SET motif family protein 0.0067 0.0121 0.0869
Brugia malayi Animal haem peroxidase family protein 0.00552502 0.5 0.5
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0071 0.0133 0.1402
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Onchocerca volvulus 0.00552502 0.5 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0071 0.0133 0.0888
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0207 0.0537 0.1819
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0715
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0026 0.0012
Echinococcus granulosus Immunoglobulin 0.0041 0.0043 0.0064
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0041 0.0043 0.0064
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0197 0.0507 0.3383
Echinococcus multilocularis roundabout 2 0.0054 0.0082 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0036 0.0218
Echinococcus multilocularis dna polymerase eta 0.0071 0.0133 0.0119
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Brugia malayi RNA, U transporter 1 0.0092 0.0195 0.1438
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0131 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Trypanosoma brucei glucosidase, putative 0.0042 0.0046 0.0409
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0014 0.0046
Trypanosoma brucei DNA polymerase eta, putative 0.0071 0.0133 0.1324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0091 0.0151
Brugia malayi nuclear receptor NHR-88 0.0038 0.0036 0.0218
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0118 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.0161 0.0614
Brugia malayi Probable ClpP-like protease 0.0356 0.0978 0.746
Mycobacterium ulcerans hypothetical protein 0.0182 0.0464 0.229
Brugia malayi Animal haem peroxidase family protein 0.0138 0.0332 0.2492
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.0482 0.3649
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0131 0.0445
Mycobacterium tuberculosis Probable dehydrogenase 0.0468 0.1311 0.4711
Loa Loa (eye worm) beta-lactamase 0.0148 0.0361 0.2716
Loa Loa (eye worm) blistered cuticle protein 3 0.0138 0.0332 0.2492
Plasmodium falciparum glutathione reductase 0.0071 0.0133 0.1291
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Onchocerca volvulus 0.0532 0.1499 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0086 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0091 0.0151
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0057 0.0599
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0014 0.0046
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0034 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0036 0.0218
Mycobacterium ulcerans hypothetical protein 0.0148 0.0361 0.1721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0294 0.0795 0.1745
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0133 0.096
Onchocerca volvulus Peroxidasin homolog 0.00552502 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0776
Echinococcus multilocularis cysteine protease 0.0039 0.0037 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0036 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0133 0.1402
Mycobacterium ulcerans beta-lactamase 0.0148 0.0361 0.1721
Echinococcus multilocularis thioredoxin glutathione reductase 0.0205 0.0531 0.0518
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0036 0.0218
Onchocerca volvulus 0.0081 0.0161 0.0993
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0039 0.0037 0.0221
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0058 0.0093 0.0653
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.0727 0.0714
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0361 0.2716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0121 0.0239
Mycobacterium tuberculosis Conserved protein 0.0148 0.0361 0.116
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0361 0.118
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0046 0.0917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0037 0.0051
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.0482 0.1046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0046 0.031
Echinococcus granulosus geminin 0.0535 0.1508 0.3336
Echinococcus multilocularis peptidase Clp (S14 family) 0.0233 0.0614 0.0601
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0118 0.0104
Leishmania major DNA polymerase eta, putative 0.0071 0.0133 0.1397
Brugia malayi jmjC domain containing protein 0.0035 0.0026 0.0139
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0118 0.0104
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0081 0.0161 0.0614
Trypanosoma brucei unspecified product 0.0043 0.0051 0.0453
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0036 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0037 0.0387
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0356 0.0978 0.4824
Echinococcus multilocularis snurportin 1 0.0345 0.0946 0.0933
Onchocerca volvulus Chorion peroxidase homolog 0.0138 0.0332 0.2141
Onchocerca volvulus 0.0067 0.0121 0.072
Brugia malayi glutathione reductase 0.0205 0.0531 0.4024
Schistosoma mansoni hypothetical protein 0.0055 0.0086 0.0162
Trichomonas vaginalis rotamase, putative 0.0039 0.0037 0.0247
Onchocerca volvulus Peroxidase homolog 0.00552502 0.5 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0361 0.0775
Loa Loa (eye worm) blistered cuticle protein 3 0.00552502 0.5 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0294 0.0795 0.0783
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0137 0.1442
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0036 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0361 0.116
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0034 0.0361
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0026 0.0139
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0072 0.0137 0.1442
Echinococcus granulosus lysine specific demethylase 5A 0.0131 0.0312 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Onchocerca volvulus 0.0138 0.0332 0.2141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0468 0.1311 0.4711
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0356 0.0978 1
Leishmania major hypothetical protein, conserved 0.0148 0.0361 0.3801
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0107 0.1017
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0197 0.0507 0.4599
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0051 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Echinococcus multilocularis cysteine protease 0.0039 0.0037 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0036 0.0151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0076 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Plasmodium falciparum importin beta, putative 0.0032 0.0018 0.0105
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0069 0.0128 0.0114
Leishmania major hypothetical protein, conserved 0.0035 0.0026 0.0275
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0346 0.095 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0039 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0376
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0086 0.0603
Brugia malayi jmjC domain containing protein 0.0131 0.0312 0.2337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0036 0.005
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0468 0.1311 0.4711
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0067 0.0624
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0361 0.3748
Giardia lamblia Fructose-bisphosphate aldolase 0.0141 0.034 0.6333
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0148 0.0362 0.7131
Brugia malayi hypothetical protein 0.00552502 0.5 0.5
Onchocerca volvulus 0.0038 0.0036 0.0151
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0036 0.005
Plasmodium vivax JmjC domain containing protein 0.0035 0.0026 0.0187
Onchocerca volvulus Peroxidasin homolog 0.0138 0.0332 0.2141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0715
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0361 0.116
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0468 0.1311 0.4711
Plasmodium vivax vivapain-2 0.0039 0.0037 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0131 0.1268
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0051 0.0329
Loa Loa (eye worm) animal heme peroxidase 0.00552502 0.5 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0141 0.034 0.6699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Brugia malayi jmjC domain containing protein 0.0035 0.0026 0.0139
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0026 0.0275
Echinococcus multilocularis microtubule associated protein 2 0.1541 0.4493 0.4485
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0361 0.2408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0503 0.3353
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0131 0.0261
Echinococcus granulosus acetylcholinesterase 0.0066 0.0118 0.0232
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0161 0.1181
Brugia malayi Animal haem peroxidase family protein 0.0138 0.0332 0.2492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0036 0.0151
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0036 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.052
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0071 0.0133 0.0308
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.0161 0.17
Mycobacterium tuberculosis Probable reductase 0.0468 0.1311 0.4711
Brugia malayi RNA binding protein 0.0073 0.014 0.1015
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0057 0.0096
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0482 0.0469
Entamoeba histolytica cysteine protease, putative 0.0039 0.0037 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0046 0.031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0036 0.0022
Brugia malayi steroid hormone receptor 0.0038 0.0036 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0467 0.1308 1
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0161 0.1181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0158 0.0144
Schistosoma mansoni peroxidasin 0.0151 0.0371 0.0798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0051 0.0534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0294 0.0795 0.1745
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0086 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0036 0.0022
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0482 0.0469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0026 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0361 0.116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0121 0.0239
Onchocerca volvulus Cathepsin F homolog 0.0039 0.0037 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0036 0.0022
Schistosoma mansoni phosphoglycerate kinase 0.0197 0.0507 0.1101
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0057 0.0043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0233 0.0614 0.2675
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0359 0.3775
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0121 0.0239
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0051 0.0453
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.0946 0.7217
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0076 0.052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0036 0.0022
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0039 0.0037 0.0297
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.0053 0.0079 0.0549
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0039 0.0037 0.0023
Loa Loa (eye worm) ctsf protein 0.0039 0.0037 0.0221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0036 0.005
Leishmania major cathepsin L-like protease 0.0147 0.0359 0.3775
Brugia malayi Blistered cuticle protein 3 0.00552502 0.5 0.5
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0026 0.0027
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.052 0.1466 0.529
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0409 0.4301
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 0.5142
Schistosoma mansoni cell adhesion molecule 0.0054 0.0082 0.0152
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0651 0.1854 1
Schistosoma mansoni coup transcription factor 0.0038 0.0036 0.005
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0206 0.0534 0.052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0043 0.0266
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0197 0.0507 0.534
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0107 0.031
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0109 0.0095
Loa Loa (eye worm) glutathione reductase 0.0205 0.0531 0.4024
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0026 0.0027
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0118 0.0232
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.0321 0.3376
Echinococcus multilocularis peroxidasin 0.00552502 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0076 0.052
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.0312 0.2337
Brugia malayi Animal haem peroxidase family protein 0.00552502 0.5 0.5
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0034 0.0361
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0026 0.0275
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221
Schistosoma mansoni hypothetical protein 0.0052 0.0076 0.0138
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Mycobacterium tuberculosis Conserved protein 0.0148 0.0361 0.116
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0036 0.005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0026 0.0187
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0077 0.0532
Loa Loa (eye worm) RNA binding protein 0.0073 0.014 0.1015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0139
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0071 0.0133 0.0458
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0036 0.0022
Onchocerca volvulus 0.0039 0.0037 0.0153
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0109 0.0776
Loa Loa (eye worm) hypothetical protein 0.0271 0.0727 0.5531
Onchocerca volvulus 0.0039 0.0037 0.0153
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0014 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0361 0.0348
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0086 0.0161
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0133 0.0305
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0086 0.0161
Leishmania major 4-coumarate:coa ligase-like protein 0.0081 0.0161 0.17
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0148 0.0362 0.2721
Onchocerca volvulus Peroxidase homolog 0.0138 0.0332 0.2141
Brugia malayi intermediate filament protein 0.0031 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0568
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0071 0.0133 0.1329
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0008 0.0084
Onchocerca volvulus 0.0148 0.0361 0.2337
Plasmodium falciparum cysteine proteinase falcipain 3 0.0039 0.0037 0.0297
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0139
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0086 0.0161
Plasmodium vivax glutathione reductase, putative 0.0205 0.0531 0.5394
Leishmania major cathepsin L-like protease 0.0039 0.0037 0.0387
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0071 0.0133 0.1329
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0361 0.2408
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0026 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0107 0.1122
Schistosoma mansoni survival motor neuron protein 0.0055 0.0086 0.0162
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0361 0.1721
Trichomonas vaginalis mercuric reductase, putative 0.0071 0.0133 0.0888
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0046 0.0489
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0069 0.0128 0.1271
Onchocerca volvulus 0.0039 0.0037 0.0153
Loa Loa (eye worm) MBCTL1 0.0063 0.0109 0.0776
Toxoplasma gondii NADPH-glutathione reductase 0.0071 0.0133 0.1291
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0086 0.0161
Echinococcus granulosus defective proboscis extension response 0.0041 0.0043 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0098 0.1035
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0131 0.0445
Echinococcus granulosus cathepsin l1 0.0039 0.0037 0.0051
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0026 0.0027
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0057 0.0096
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0197 0.0507 0.3383
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0037 0.0221
Plasmodium falciparum thioredoxin reductase 0.0071 0.0133 0.1291
Brugia malayi Animal haem peroxidase family protein 0.00552502 0.5 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0076 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0294 0.0795 0.1745
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0039 0.0037 0.0245
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0046 0.0296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0294 0.0795 0.6058
Plasmodium falciparum glutathione reductase 0.0205 0.0531 0.5394
Trypanosoma brucei unspecified product 0.003 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0071 0.0133 0.1291
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0051 0.0037
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0131 0.1378
Echinococcus granulosus dna polymerase kappa 0.0043 0.0051 0.0082
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0137 0.1442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0464 0.1543
Onchocerca volvulus 0.00552502 0.5 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0008 0.0084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0046 0.031
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0361 0.2408
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0133 0.1402
Treponema pallidum phosphoglycerate kinase 0.0197 0.0507 0.4599
Leishmania major cathepsin L-like protease 0.0039 0.0037 0.0387
Trichomonas vaginalis esterase, putative 0.0148 0.0361 0.2408
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0945 0.2726 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0037 0.0245
Brugia malayi hypothetical protein 0.0041 0.0043 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0091 0.0151
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0069 0.0128 0.1271
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0181 0.0461 0.3481
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0051 0.0037
Brugia malayi beta-lactamase family protein 0.0148 0.0361 0.2716
Brugia malayi hypothetical protein 0.008 0.0158 0.1154
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0051 0.0082
Trichomonas vaginalis set domain proteins, putative 0.0532 0.1499 1
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Echinococcus granulosus tar DNA binding protein 0.0073 0.014 0.0281
Loa Loa (eye worm) thioredoxin reductase 0.0205 0.0531 0.4024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0071 0.0133 0.1807
Toxoplasma gondii ABC1 family protein 0.0148 0.0361 0.3641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0093 0.0653
Onchocerca volvulus Peroxidasin homolog 0.00552502 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Onchocerca volvulus 0.0039 0.0037 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.052 0.1466 0.529
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0715
Loa Loa (eye worm) animal heme peroxidase 0.0138 0.0332 0.2492
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0207 0.0537 0.2699
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Schistosoma mansoni alpha glucosidase 0.0042 0.0046 0.0073
Echinococcus multilocularis cathepsin L cysteine protease 0.0039 0.0037 0.0023
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Echinococcus granulosus dna polymerase eta 0.0071 0.0133 0.0265
Loa Loa (eye worm) hypothetical protein 0.0112 0.0254 0.189
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0026 0.0027
Schistosoma mansoni hypothetical protein 0.0345 0.0946 0.2081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0207 0.0537 0.5655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Plasmodium vivax importin-beta 2, putative 0.0032 0.0018 0.0105
Echinococcus multilocularis transcription factor Dp 1 0.0086 0.0177 0.0163
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0362 0.3808
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0568
Brugia malayi Carboxylesterase family protein 0.0066 0.0118 0.0844
Leishmania major cathepsin L-like protease 0.0039 0.0037 0.0387
Onchocerca volvulus 0.0055 0.0086 0.0487
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0057 0.0043
Echinococcus granulosus twitchin 0.0041 0.0043 0.0064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0312 0.0665
Loa Loa (eye worm) hypothetical protein 0.0081 0.0161 0.1181
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0071 0.0133 0.0458
Trypanosoma cruzi major cysteine proteinase, putative 0.0116 0.0265 0.2792
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0356 0.0978 0.2152
Brugia malayi TAR-binding protein 0.0073 0.014 0.1015
Loa Loa (eye worm) hypothetical protein 0.009 0.0188 0.1386
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0118 0.0844
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0036 0.005
Brugia malayi jmjC domain containing protein 0.0131 0.0312 0.2337
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0123 0.0286 0.0735
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0069 0.0128 0.0254
Plasmodium falciparum phosphoglycerate kinase 0.0197 0.0507 0.5149
Trypanosoma cruzi cruzipain precursor, putative 0.0147 0.0359 0.3775
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0037 0.0223
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0036 0.005
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0034 0.0361
Echinococcus granulosus microtubule associated protein 2 0.1541 0.4493 1
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0294 0.0795 0.1745
Schistosoma mansoni nephrin 0.0041 0.0043 0.0064
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0346 0.095 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0294 0.0795 0.6058
Brugia malayi Phosphoglycerate kinase 0.0197 0.0507 0.3841
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0081 0.0161 0.0414
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0036 0.0218
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0034 0.028
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0057 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0133 0.1329
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0051 0.0082
Trypanosoma brucei trypanothione reductase 0.0205 0.0531 0.5553
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0148 0.0362 0.0776
Mycobacterium tuberculosis Conserved protein 0.0148 0.0361 0.116
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0057 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0026 0.0027
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0057 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0131 0.0312 0.0298
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0361 0.1721
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Leishmania major cathepsin L-like protease 0.0147 0.0359 0.3775
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0207 0.0537 0.1168
Schistosoma mansoni ap endonuclease 0.0062 0.0107 0.0207
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0026 0.0027
Onchocerca volvulus 0.0109 0.0246 0.1563
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.052 0.1466 0.7709
Toxoplasma gondii hypothetical protein 0.0056 0.0088 0.0825
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0107 0.0093
Loa Loa (eye worm) hypothetical protein 0.0151 0.0371 0.2794
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0036 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Loa Loa (eye worm) hypothetical protein 0.0031 0.0014 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0037 0.0247
Plasmodium falciparum thioredoxin reductase 0.0205 0.0531 0.5394
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0361 0.0775
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0051 0.1
Brugia malayi Animal haem peroxidase family protein 0.0138 0.0332 0.2492
Schistosoma mansoni rotamase 0.0039 0.0037 0.0051
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0069 0.0128 0.1345
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0036 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.0762 0.508
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0046 0.031
Brugia malayi MH2 domain containing protein 0.0138 0.0332 0.2496
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0051 0.0329
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0359 0.3775
Schistosoma mansoni importin beta-1 0.0032 0.0018 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0036 0.0218
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0067 0.0703
Brugia malayi mbt repeat family protein 0.0055 0.0086 0.0602
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0161 0.1181
Echinococcus multilocularis geminin 0.0535 0.1508 0.1496
Treponema pallidum fructose-bisphosphate aldolase 0.0141 0.034 0.2677
Plasmodium falciparum acyl-CoA synthetase 0.006 0.0101 0.0959
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0076 0.0062
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0044 0.0465
Schistosoma mansoni peroxidasin 0.0138 0.0332 0.071
Brugia malayi jmjC domain containing protein 0.0035 0.0026 0.0139
Echinococcus multilocularis lysine specific demethylase 5A 0.0131 0.0312 0.0298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0036 0.005
Brugia malayi hypothetical protein 0.0138 0.0332 0.2492
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0036 0.0218
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Onchocerca volvulus 0.0039 0.0037 0.0153
Echinococcus granulosus cathepsin l cysteine peptidase 0.0039 0.0037 0.0051
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0069 0.0128 0.1345
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0039 0.0037 0.0245
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0071 0.0133 0.0266
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0207 0.0537 0.4072
Loa Loa (eye worm) cysteine protease 0.0039 0.0037 0.0221
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0207 0.0537 0.2699
Echinococcus granulosus Dipeptidyl peptidase 9 0.0069 0.0128 0.0254
Leishmania major phosphoglycerate kinase C, glycosomal 0.0197 0.0507 0.534
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0065 0.0114 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.0161 0.3183
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0121 0.0239
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0057 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0361 0.2408
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Plasmodium vivax phosphoglycerate kinase, putative 0.0197 0.0507 0.5149
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0081 0.0161 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0503 0.3353
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0086 0.0602
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 1
Schistosoma mansoni vesicular amine transporter 0.0041 0.0043 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0133 0.1329
Brugia malayi Phosphoglycerate kinase 0.0072 0.0137 0.0992
Loa Loa (eye worm) hypothetical protein 0.0081 0.0161 0.1181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0356 0.0978 0.5142
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0067 0.0703
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0158 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0039 0.0037 0.0023
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0148 0.0362 0.2721
Brugia malayi hypothetical protein 0.0053 0.0079 0.0549
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0361 0.116
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0362 0.3808
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0026 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0036 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0073 0.014 0.0281
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0148 0.0362 0.3755
Schistosoma mansoni hypothetical protein 0.0052 0.0076 0.0138
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0205 0.0531 0.1796
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0361 0.116
Brugia malayi beta-lactamase family protein 0.0148 0.0361 0.2716
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0361 0.3641
Brugia malayi Importin beta-1 subunit 0.0032 0.0018 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0361 0.0775
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0118 0.0232
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0332 0.2496
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0011 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0036 0.0218
Leishmania major cathepsin L-like protease 0.0039 0.0037 0.0387
Brugia malayi Fibronectin type III domain containing protein 0.0041 0.0043 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0036 0.005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.0482 0.3649
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0131 0.0312 0.0665
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.0161 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0011 0.003
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.0727 0.1592
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Echinococcus granulosus roundabout 2 0.0054 0.0082 0.0152
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0046 0.0397
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0121 0.1165
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0346 0.095 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0107 0.1122
Onchocerca volvulus 0.0039 0.0037 0.0153
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0081 0.0161 0.0614
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0107 0.1224
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0141 0.034 0.6699
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Trypanosoma brucei phosphoglycerate kinase 0.0072 0.0137 0.1369
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0036 0.005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0109 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0036 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0121 0.0239
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0046 0.031
Echinococcus granulosus expressed protein 0.0039 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Onchocerca volvulus 0.0039 0.0037 0.0153
Loa Loa (eye worm) hypothetical protein 0.0356 0.0978 0.746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0036 0.0218
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0067 0.0703
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0036 0.0218
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0107 0.1017
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0109 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Schistosoma mansoni hypothetical protein 0.0535 0.1508 0.3336
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0131 0.0261
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0131 0.0261
Leishmania major cathepsin L-like protease 0.0147 0.0359 0.3775
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0057 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0046 0.0489
Schistosoma mansoni ap endonuclease 0.0062 0.0107 0.0207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0361 0.2716
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0148 0.0362 0.3808
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0071 0.0133 0.1291
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.0359 0.3775
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0137 0.1442
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0026 0.0187
Echinococcus granulosus thioredoxin glutathione reductase 0.0205 0.0531 0.1154
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0361 0.2408
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0294 0.0795 0.1745
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0107 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0018 0.0105
Echinococcus granulosus endonuclease exonuclease phosphatase 0.023 0.0606 0.1321
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0148 0.0362 0.0776
Entamoeba histolytica acyl-coA synthetase, putative 0.0081 0.0161 0.3183
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0026 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0046 0.0489
Schistosoma mansoni alpha-glucosidase 0.0163 0.0404 0.0871
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0188 0.371
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0086 0.0072
Loa Loa (eye worm) hypothetical protein 0.0138 0.0332 0.2492
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0071 0.0133 0.1291
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0036 0.0218
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0071 0.0133 0.0458
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0137 0.1442
Echinococcus granulosus peptidase Clp S14 family 0.0233 0.0614 0.134
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.0762 0.5798
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0046 0.0917
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0071 0.0133 0.0963
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0037 0.0725
Toxoplasma gondii thioredoxin reductase 0.0205 0.0531 0.5394
Loa Loa (eye worm) hypothetical protein 0.0148 0.0361 0.2716
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0036 0.0022
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0197 0.0507 0.1707
Loa Loa (eye worm) hypothetical protein 0.00552502 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.0407 0.307
Echinococcus granulosus transcription factor Dp 1 0.0086 0.0177 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0051 0.0453
Echinococcus granulosus peroxidasin 0.00552502 0.5 0.5
Brugia malayi Blistered cuticle protein 3 0.0138 0.0332 0.2492
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0076 0.0062
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0131 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0046 0.031
Onchocerca volvulus Chorion peroxidase homolog 0.00552502 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Echinococcus granulosus cathepsin L cysteine proteinase 0.0039 0.0037 0.0051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0086 0.0486
Brugia malayi Peroxidasin 0.00552502 0.5 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0361 0.116
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.023 0.0606 0.0592
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0057 0.1122
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0036 0.0218
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0651 0.1854 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0057 0.038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0036 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0037 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0036 0.0218
Leishmania major phosphoglycerate kinase B, cytosolic 0.0197 0.0507 0.534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Echinococcus multilocularis tar DNA binding protein 0.0073 0.014 0.0126
Schistosoma mansoni DNA polymerase eta 0.0071 0.0133 0.0265
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0018 0.0108
Loa Loa (eye worm) hypothetical protein 0.0081 0.0161 0.1181
Brugia malayi mbt repeat family protein 0.0055 0.0086 0.0602
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1449 0.422 0.939
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0051 0.0453
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0207 0.0537 0.0524
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0081 0.0161 0.0414
Entamoeba histolytica hypothetical protein 0.008 0.0158 0.3116
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0051 0.0338
Echinococcus granulosus phosphoglycerate kinase 1 0.0197 0.0507 0.1101
Onchocerca volvulus 0.0138 0.0332 0.2141
Schistosoma mansoni hypothetical protein 0.008 0.0158 0.0322
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0473 0.3155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0037 0.0245
Brugia malayi prolyl oligopeptidase family protein 0.0206 0.0534 0.4043
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.014 0.1015
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0036 0.0218
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0039 0.0037 0.0297
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0568
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0266
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0218
Schistosoma mansoni hypothetical protein 0.0052 0.0076 0.0138
Onchocerca volvulus 0.005 0.0069 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.0161 0.0614
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0036 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0332 0.2496
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0054 0.0082 0.0152
Echinococcus multilocularis GPCR, family 2 0.0052 0.0076 0.0062
Loa Loa (eye worm) TAR-binding protein 0.0073 0.014 0.1015
Loa Loa (eye worm) animal heme peroxidase 0.00552502 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0197 0.0507 0.3841
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0141 0.034 0.2267
Echinococcus granulosus importin subunit beta 1 0.0032 0.0018 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0407 0.307
Echinococcus granulosus acetylcholinesterase 0.0066 0.0118 0.0232
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0356 0.0978 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0109 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0073 0.014 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.038
Treponema pallidum NADH oxidase 0.0071 0.0133 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0138 0.0332 0.2492
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0034 0.0272
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0046 0.0073
Loa Loa (eye worm) animal heme peroxidase 0.00552502 0.5 0.5
Trypanosoma brucei phosphoglycerate kinase 0.0197 0.0507 0.53
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0036 0.005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0037 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0011 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0036 0.0218
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0137 0.1442
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0057 0.0599
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0133 0.1402
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0121 0.0107
Echinococcus multilocularis peroxidasin 0.0151 0.0371 0.0358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0407 0.307
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.0762 0.5798
Onchocerca volvulus Peroxidase homolog 0.0138 0.0332 0.2141
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0046 0.0296
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0207 0.0537 0.1168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.0359 0.3722
Brugia malayi hypothetical protein 0.0271 0.0727 0.5531
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0057 0.038
Brugia malayi Cathepsin L-like precursor 0.0039 0.0037 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.49 uM Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 infected in mouse macrophage by reporter dye assay ChEMBL. 17698622
IC50 (functional) = 0.85 uM Antitrypanosomal activity against tbat1 knockout Trypanosoma cruzi BS221 infected in mouse macrophage by reporter dye assay ChEMBL. 17698622
IC50 (functional) = 1.26 uM Antitrypanosomal activity against wild type Trypanosoma cruzi BS221 infected in mouse macrophage by reporter dye assay ChEMBL. 17698622
IC50 (functional) = 9.05 uM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay ChEMBL. 17698622
Ratio IC50 (functional) = 0.67 Resistance factor, ratio of IC50 for tbat1 knock out Trypanosoma cruzi BS221 to IC50 for wild type Trypanosoma cruzi BS221 ChEMBL. 17698622

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 17698622
Trypanosoma cruzi ChEMBL23 17698622
Trypanosoma brucei gambiense 17698622

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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