Detailed information for compound 1033058

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 571.064 | Formula: C29H35ClN4O6
  • H donors: 1 H acceptors: 3 LogP: 3.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1c(C)[nH]c2c1C1CCN(C1=CC2C(=O)ON1CCN(CC1)C)C(=O)/C=C/c1ccc(cc1)OC.Cl
  • InChi: 1S/C29H34N4O6.ClH/c1-18-25(29(36)38-4)26-21-11-12-33(24(34)10-7-19-5-8-20(37-3)9-6-19)23(21)17-22(27(26)30-18)28(35)39-32-15-13-31(2)14-16-32;/h5-10,17,21-22,30H,11-16H2,1-4H3;1H/b10-7+;
  • InChiKey: DGOLKDVBUXVVCW-HCUGZAAXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0153 0.1078 0.1078
Schistosoma mansoni tyrosine kinase 0.0614 0.4648 0.4648
Echinococcus granulosus tyrosine protein kinase Src42A 0.0531 0.4012 0.4012
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0021 0.0061 0.0061
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0061 0.0369 0.0376
Echinococcus multilocularis suppressor of cytokine signaling 7 0.007 0.0443 0.0443
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0126 0.0126
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0394 0.0394
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Toxoplasma gondii thioredoxin reductase 0.0038 0.0194 0.0992
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0349 0.0349
Schistosoma mansoni methylthioadenosine phosphorylase 0.0266 0.1954 0.1954
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0266 0.1954 0.1988
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0021 0.0061 0.0061
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0068 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0068 0.0068
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0361
Schistosoma mansoni ephrin receptor 0.0021 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0068 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0068 0.0069
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0021 0.0061 0.0062
Plasmodium falciparum protein kinase, putative 0.0021 0.0061 0.0311
Echinococcus granulosus retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Echinococcus granulosus c src tyrosine kinase 0.0153 0.1078 0.1078
Echinococcus multilocularis tyrosine protein kinase HCK 0.0482 0.363 0.363
Schistosoma mansoni tyrosine kinase 0.0092 0.0607 0.0607
Echinococcus multilocularis suppressor of cytokine signaling 6 0.007 0.0443 0.0443
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0369 0.1889
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Onchocerca volvulus 0.0092 0.0607 0.0559
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0061 0.0369 0.0369
Entamoeba histolytica protein kinase, putative 0.0071 0.0444 0.1074
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0614 0.4648 0.4648
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis snurportin 1 0.0325 0.241 0.241
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0266 0.1954 1
Brugia malayi Importin beta-1 subunit 0.003 0.0133 0.0135
Echinococcus multilocularis integrin linked protein kinase 0.0021 0.0061 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0133 0.0679
Echinococcus multilocularis muscleblind protein 0.0316 0.2346 0.2346
Schistosoma mansoni uridine phosphorylase 0.0266 0.1954 0.1954
Trypanosoma brucei conserved protein 0.0061 0.0369 0.1889
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0071 0.0444 0.1074
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Toxoplasma gondii phosphorylase family protein 0.0266 0.1954 1
Echinococcus multilocularis activin receptor type 0.0021 0.0062 0.0062
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Echinococcus granulosus geminin 0.0352 0.262 0.262
Echinococcus granulosus suppressor of cytokine signaling 7 0.007 0.0443 0.0443
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0068 0.0069
Loa Loa (eye worm) glutathione reductase 0.0038 0.0194 0.0245
Echinococcus granulosus tyrosine protein kinase Blk 0.0553 0.4176 0.4176
Schistosoma mansoni protein kinase 0.0021 0.0062 0.0062
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.5306 0.5306
Echinococcus granulosus nostrin 0.0061 0.0369 0.0369
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase shark 0.0429 0.3218 0.3218
Schistosoma mansoni serine/threonine RGC 0.0021 0.0061 0.0061
Chlamydia trachomatis AMP nucleosidase 0.0266 0.1954 1
Brugia malayi Protein kinase domain containing protein 0.0092 0.0607 0.0617
Echinococcus granulosus methylthioadenosine phosphorylase 0.0266 0.1954 0.1954
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.1283 0.983 1
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Echinococcus granulosus tyrosine protein kinase csk 0.0021 0.0061 0.0061
Onchocerca volvulus 0.0028 0.0117 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0012
Echinococcus multilocularis raf serine:threonine protein kinase 0.0026 0.0098 0.0098
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0075 0.048 0.0613
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0215 0.0215
Plasmodium vivax hypothetical protein, conserved 0.003 0.0126 0.0646
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0394 0.0502
Mycobacterium leprae probable uridine phosphorylase 0.0266 0.1954 0.1491
Echinococcus multilocularis tyrosine protein kinase csk 0.0021 0.0061 0.0061
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0068 0.0069
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0068 0.0068
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Echinococcus multilocularis tensin 0.007 0.0443 0.0443
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Onchocerca volvulus 0.0022 0.0068 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.0369 0.0864
Echinococcus multilocularis SH2 motif 0.007 0.0443 0.0443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0068 0.0068
Treponema pallidum pfs protein (pfs) 0.0266 0.1954 1
Entamoeba histolytica hypothetical protein 0.0266 0.1954 0.5304
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0614 0.4648 0.4648
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0117 0.0117
Plasmodium falciparum thioredoxin reductase 0.0038 0.0194 0.0992
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0266 0.1954 0.5304
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0394 0.0502
Brugia malayi Furin-like cysteine rich region family protein 0.0139 0.0973 0.099
Brugia malayi tRNA modification GTPase TrmE family protein 0.007 0.0443 0.0451
Brugia malayi SH3 domain containing protein 0.0061 0.0369 0.0376
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0021 0.0061 0.0062
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0088 0.0451
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Mycobacterium tuberculosis Probable reductase 0.0087 0.0574 0.0584
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.007 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Giardia lamblia Kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0131 0.0915 0.1173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Echinococcus granulosus signal transduction protein lnk realted 0.007 0.0443 0.0443
Schistosoma mansoni tyrosine kinase 0.0084 0.0548 0.0548
Onchocerca volvulus 0.007 0.0443 0.0391
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0068 0.0068
Entamoeba histolytica Ran family GTPase 0.0022 0.007 0.0027
Onchocerca volvulus 0.0061 0.0369 0.0316
Brugia malayi Src substrate cortactin 0.0061 0.0369 0.0376
Plasmodium vivax tyrosine kinase-like protein, putative 0.0021 0.0061 0.0311
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0133 0.0679
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Brugia malayi Thioredoxin reductase 0.0038 0.0194 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0068 0.0069
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0021 0.0061 0.0061
Trypanosoma brucei trypanothione reductase 0.0038 0.0194 0.0992
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Echinococcus granulosus SH2 domain containing adapter protein F 0.007 0.0443 0.0443
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0215 0.0272
Echinococcus granulosus tyrosine protein kinase Srms 0.0092 0.0607 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Brugia malayi hypothetical protein 0.007 0.0443 0.0451
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.007 0.0361
Onchocerca volvulus 0.0061 0.0369 0.0316
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0068 0.0007
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi SH2 domain containing protein 0.0092 0.0607 0.0617
Brugia malayi Protein kinase domain containing protein 0.0092 0.0607 0.0617
Echinococcus granulosus activated cdc42 kinase 1 0.0021 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0063 0.0385 0.0385
Brugia malayi jmjC domain containing protein 0.0041 0.0215 0.0218
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0649 0.0082
Loa Loa (eye worm) protein-tyrosine kinase 0.0061 0.0369 0.0471
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni growth factor receptor-bound protein 0.0131 0.0915 0.0915
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0068 0.0068
Onchocerca volvulus 0.0092 0.0607 0.0559
Onchocerca volvulus 0.007 0.0443 0.0391
Loa Loa (eye worm) TK protein kinase 0.0553 0.4176 0.537
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0061 0.0369 0.0369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0266 0.1954 0.1988
Echinococcus multilocularis tyrosine protein kinase Srms 0.0553 0.4176 0.4176
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0068 0.0068
Echinococcus granulosus integrin linked protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0266 0.1954 0.1954
Toxoplasma gondii STE kinase 0.0021 0.0061 0.0311
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus peregrin 0.003 0.0126 0.0126
Brugia malayi protein-tyrosine kinase 0.0553 0.4176 0.4248
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0062 0.0317
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0023 0.0075 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0266 0.1954 0.1988
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Schistosoma mansoni hypothetical protein 0.0061 0.0369 0.0369
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0021 0.0061 0.0062
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0153 0.1078 0.1078
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0266 0.1954 0.5304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis helicase, putative 0.0021 0.0058 0.0059
Schistosoma mansoni protein tyrosine kinase 0.0021 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Brugia malayi glutathione reductase 0.0038 0.0194 0.0197
Echinococcus granulosus suppressor of cytokine signaling 6 0.007 0.0443 0.0443
Echinococcus granulosus tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus tensin C1 domain containing phosphatase 0.007 0.0443 0.0443
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi RNA binding protein 0.0064 0.0394 0.0401
Brugia malayi hypothetical protein 0.0021 0.0061 0.0062
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Loa Loa (eye worm) TK protein kinase 0.0023 0.0075 0.0093
Entamoeba histolytica hypothetical protein 0.0036 0.0179 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0068 0.0082
Schistosoma mansoni run and tbc1 domain containing 0.0061 0.0369 0.0369
Brugia malayi Protein kinase domain containing protein 0.0092 0.0607 0.0617
Echinococcus multilocularis RNA directed DNA polymerase 0.0031 0.014 0.014
Loa Loa (eye worm) TK/EGFR protein kinase 0.0139 0.0973 0.1248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0553 0.4176 0.4176
Echinococcus granulosus epidermal growth factor receptor 0.0139 0.0973 0.0973
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0061 0.0074
Echinococcus granulosus lamin 0.0028 0.0117 0.0117
Schistosoma mansoni tyrosine kinase 0.0058 0.0349 0.0349
Loa Loa (eye worm) uridine phosphorylase 0.0266 0.1954 0.251
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.1954 0.1988
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0117 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0649 0.066
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Echinococcus multilocularis purine nucleoside phosphorylase 0.1017 0.7773 0.7773
Trypanosoma cruzi protein kinase, putative 0.0021 0.0061 0.0311
Schistosoma mansoni adapter molecule crk 0.0131 0.0915 0.0915
Echinococcus multilocularis transfer RNA-Thr 0.0021 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0036 0.0179 0.0332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0068 0.0068
Brugia malayi steroid hormone receptor 0.0022 0.0068 0.0069
Schistosoma mansoni tyrosine kinase 0.0025 0.0094 0.0094
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0068 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0068 0.0082
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0021 0.0061 0.0074
Echinococcus multilocularis insulin receptor 0.0058 0.0349 0.0349
Echinococcus granulosus protein kinase 0.0021 0.0061 0.0061
Brugia malayi ecdysteroid receptor 0.0022 0.0068 0.0069
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0061 0.0369 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Giardia lamblia UPL-1 0.0266 0.1954 0.1988
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0088 0.009
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0068 0.0082
Brugia malayi Tyrosine-protein kinase abl-1 0.0153 0.1078 0.1097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0068 0.0068
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0068 0.0082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0216 0.0216
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0068 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0021 0.0062 0.0062
Schistosoma mansoni suppressor of cytokine signaling 0.007 0.0443 0.0443
Echinococcus multilocularis lamin dm0 0.0028 0.0117 0.0117
Trypanosoma brucei Flagellum attachment zone protein 20 0.0021 0.0061 0.0311
Brugia malayi hypothetical protein 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Trypanosoma brucei uridine phosphorylase 0.0266 0.1954 1
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0061 0.0369 0.0369
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0068 0.0068
Brugia malayi MTAP 0.0266 0.1954 0.1988
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus tyrosine protein kinase Src42A 0.0614 0.4648 0.4648
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0061 0.0369 0.0369
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Brugia malayi Sex muscle abnormal protein 5 0.0131 0.0915 0.0931
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Trichomonas vaginalis TK family protein kinase 0.0021 0.0061 0.0062
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Brugia malayi jmjC domain containing protein 0.0097 0.0647 0.0658
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Loa Loa (eye worm) hypothetical protein 0.0131 0.0915 0.1173
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.007 0.0443 0.0391
Schistosoma mansoni tyrosine kinase 0.0429 0.3218 0.3218
Trypanosoma brucei protein kinase, putative 0.0021 0.0062 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi Bromodomain containing protein 0.003 0.0126 0.0128
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0266 0.1954 0.1988
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0068 0.0068
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0031 0.014 0.014
Loa Loa (eye worm) SH2 domain-containing protein 0.007 0.0443 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus intermediate filament protein 0.0028 0.0117 0.0117
Brugia malayi Protein-tyrosine phosphatase containing protein 0.007 0.0443 0.0451
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0068 0.0068
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.007 0.0443 0.0443
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0021 0.0061 0.0062
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0061 0.0074
Brugia malayi Protein kinase domain containing protein 0.0092 0.0607 0.0617
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Schistosoma mansoni protein kinase 0.0021 0.0062 0.0062
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.007 0.0443 0.0443
Echinococcus granulosus SH2 motif 0.007 0.0443 0.0443
Echinococcus granulosus receptor type guanylyl cyclase 0.0021 0.0061 0.0061
Brugia malayi cytokine inducible SH2-containing protein 5 0.007 0.0443 0.0451
Loa Loa (eye worm) hypothetical protein 0.0092 0.0607 0.0776
Echinococcus multilocularis SHC transforming protein 3 0.007 0.0443 0.0443
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0092 0.0607 0.1529
Echinococcus granulosus expressed protein 0.0061 0.0369 0.0369
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Plasmodium falciparum glutathione reductase 0.0038 0.0194 0.0992
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.007 0.0443 0.0391
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0092 0.0607 0.0607
Schistosoma mansoni tensin 0.007 0.0443 0.0443
Echinococcus granulosus insulin receptor 0.0058 0.0349 0.0349
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Brugia malayi RhoGAP domain containing protein 0.0075 0.048 0.0488
Schistosoma mansoni cell polarity protein 0.0061 0.0369 0.0369
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0194 0.0992
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0068 0.0068
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0021 0.0061 0.0074
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0237 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0021 0.0061 0.0311
Schistosoma mansoni ran 0.0022 0.007 0.007
Schistosoma mansoni tyrosine protein kinase 0.0021 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Schistosoma mansoni tensin-related 0.007 0.0443 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0061 0.0061
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0126 0.0126
Trichomonas vaginalis STE family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0021 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Loa Loa (eye worm) protein kinase domain-containing protein 0.0021 0.0061 0.0074
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0068 0.0069
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.007 0.0443 0.0443
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0141 0.0985 0.1264
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0068 0.0082
Brugia malayi Guanylyl cyclase protein 23 0.0021 0.0061 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.1402 0.1402
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0574 0.0584
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0068 0.0082
Brugia malayi intermediate filament protein 0.0028 0.0117 0.0119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0179 0.0179
Echinococcus granulosus retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0266 0.1954 0.5304
Brugia malayi PHD-finger family protein 0.003 0.0126 0.0128
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.014 0.0175
Schistosoma mansoni methylthioadenosine phosphorylase 0.0266 0.1954 0.1954
Echinococcus granulosus kinase suppressor of Ras 1 0.0021 0.0061 0.0061
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0021 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus tyrosine kinase 0.0021 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi integrin-linked kinase 0.0021 0.0061 0.0062
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0021 0.0061 0.0061
Brugia malayi Variant SH3 domain containing protein 0.0131 0.0915 0.0931
Toxoplasma gondii protein kinase domain-containing protein 0.0021 0.0061 0.0311
Echinococcus multilocularis lamin 0.0028 0.0117 0.0117
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0075 0.0093
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Brugia malayi CXXC zinc finger family protein 0.0092 0.0607 0.0617
Onchocerca volvulus 0.007 0.0443 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0068 0.0069
Echinococcus granulosus tyrosine protein kinase HCK 0.0482 0.363 0.363
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.007 0.0443 0.0443
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Echinococcus granulosus N chimaerin 0.0075 0.048 0.048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0614 0.4648 0.4648
Plasmodium vivax importin-beta 2, putative 0.003 0.0133 0.0679
Echinococcus granulosus SH2 domain containing protein 7 0.007 0.0443 0.0443
Echinococcus granulosus NCK adaptor protein 0.0131 0.0915 0.0915
Entamoeba histolytica SH2 domain containing protein 0.007 0.0443 0.107
Brugia malayi Spectrin alpha chain 0.0061 0.0369 0.0376
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0068 0.0068
Echinococcus multilocularis tensin 0.007 0.0443 0.0443
Schistosoma mansoni tyrosine kinase 0.0153 0.1078 0.1078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0068 0.0068
Plasmodium falciparum protein kinase, putative 0.0021 0.0061 0.0311
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0266 0.1954 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0394 0.0394
Echinococcus multilocularis cpg binding protein 0.0097 0.0647 0.0647
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0061 0.0061
Toxoplasma gondii Purine nucleoside phosphorylase 0.0266 0.1954 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0068 0.0069
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) SRC-1 0.0614 0.4648 0.5978
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0126 0.0646
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.0015 0.0078
Schistosoma mansoni lamin 0.0028 0.0117 0.0117
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Schistosoma mansoni C-fyn 0.0061 0.0369 0.0369
Echinococcus granulosus growth factor receptor bound protein 2 0.0131 0.0915 0.0915
Schistosoma mansoni purine nucleoside phosphorylase 0.1283 0.983 0.983
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0012 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi PHD-finger family protein 0.0015 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0394 0.0394
Echinococcus multilocularis expressed protein 0.0061 0.0369 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0068 0.0069
Onchocerca volvulus Tyrosine kinase homolog 0.0133 0.0924 0.0884
Brugia malayi Protein kinase domain containing protein 0.0092 0.0607 0.0617
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0266 0.1954 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0021 0.0061 0.0061
Schistosoma mansoni methylthioadenosine phosphorylase 0.0266 0.1954 0.1954
Echinococcus granulosus SHC transforming protein 3 0.007 0.0443 0.0443
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Toxoplasma gondii phosphorylase family protein 0.0266 0.1954 1
Brugia malayi Muscleblind-like protein 0.0316 0.2346 0.2386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0088 0.009
Entamoeba histolytica protein kinase, putative 0.0061 0.0369 0.0864
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.007 0.0443 0.0566
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0237 0.0237
Schistosoma mansoni hypothetical protein 0.003 0.0126 0.0126
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Echinococcus multilocularis N chimaerin 0.0075 0.048 0.048
Loa Loa (eye worm) SH2 domain-containing protein 0.007 0.0443 0.0566
Entamoeba histolytica protein kinase, putative 0.0482 0.363 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0061 0.0369 0.0369
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.241 0.3097
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0533 0.0533
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis intersectin 2 0.0062 0.0377 0.0377
Schistosoma mansoni apoptosis stimulating of P53 0.0061 0.0369 0.0369
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.007 0.0443 0.0443
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0075 0.048 0.048
Schistosoma mansoni sorting nexin 0.0061 0.0369 0.0369
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis signal transduction protein lnk realted 0.007 0.0443 0.0443
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus multilocularis transfer RNA-Ala 0.0061 0.0369 0.0369
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0021 0.0061 0.0061
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Leishmania major protein kinase, putative 0.0021 0.0062 0.0317
Brugia malayi Myosin tail family protein 0.0061 0.0369 0.0376
Schistosoma mansoni tyrosine kinase 0.0358 0.2672 0.2672
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0021 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.1283 0.983 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0.0061 0.0062
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0126 0.0646
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0607 0.0776
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0266 0.1954 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0021 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0266 0.1954 0.5304
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0179 0.0179
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0548 0.0548
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis uridine phosphorylase 1 0.0266 0.1954 0.1954
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Brugia malayi Guanylate kinase family protein 0.0061 0.0369 0.0376
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0117 0.0146
Loa Loa (eye worm) TK/DDR protein kinase 0.0021 0.0061 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0075 0.0077
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0061 0.0369 0.0369
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0015 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0058 0.0059
Schistosoma mansoni protein kinase 0.0021 0.0062 0.0062
Loa Loa (eye worm) TK/ALK protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Entamoeba histolytica unconventional myosin IB 0.0061 0.0369 0.0864
Echinococcus multilocularis protein KINase family member (kin 25) 0.0021 0.0061 0.0061
Schistosoma mansoni tensin-related 0.007 0.0443 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0061 0.0369 0.0369
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0647 0.0647
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0179 0.0179
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0614 0.4648 0.4648
Onchocerca volvulus 0.0092 0.0607 0.0559
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0073 0.0073
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0068 0.0068
Loa Loa (eye worm) TK/ACK protein kinase 0.0021 0.0061 0.0074
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0649 0.066
Brugia malayi nuclear hormone receptor 0.0022 0.0068 0.0069
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0021 0.0061 0.0061
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0194 0.0197
Echinococcus multilocularis ephrin type A receptor 4 A 0.0021 0.0061 0.0061
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0574 0.0584
Echinococcus granulosus tyrosine protein kinase pr2 0.0021 0.0061 0.0061
Plasmodium falciparum protein kinase, putative 0.0021 0.0062 0.0317
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Echinococcus multilocularis nostrin 0.0061 0.0369 0.0369
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0614 0.4648 0.4648
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0117 0.0119
Echinococcus granulosus uridine phosphorylase 1 0.0266 0.1954 0.1954
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.1283 0.983 1
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Schistosoma mansoni tensin 0.007 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0068 0.0068
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0266 0.1954 0.1988
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0068 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0068 0.0068
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0061 0.0369 0.0471
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Schistosoma mansoni protein kinase 0.0021 0.0061 0.0061
Echinococcus granulosus activated cdc42 kinase 1 0.0021 0.0061 0.0061
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0266 0.1954 1
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0073 0.0073
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0189 0.0192
Echinococcus multilocularis tyrosine protein kinase 0.0021 0.0061 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Echinococcus multilocularis SH2 motif 0.007 0.0443 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0068 0.0069
Brugia malayi Raf kinase 0.0021 0.0061 0.0062
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0266 0.1954 1
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Schistosoma mansoni purine nucleoside phosphorylase 0.1283 0.983 0.983
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0068 0.0068
Echinococcus multilocularis protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0061 0.0369 0.0369
Echinococcus granulosus fibroblast growth factor receptor 4 0.0021 0.0061 0.0061
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Schistosoma mansoni eps8-related protein 0.0061 0.0369 0.0369
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni coup transcription factor 0.0022 0.0068 0.0068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0117 0.0147
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0061 0.0369 0.0369
Onchocerca volvulus Alhambra homolog 0.003 0.0126 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Brugia malayi Fes/CIP4 homology domain containing protein 0.0061 0.0369 0.0376
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0153 0.1078 0.1078
Echinococcus multilocularis 0.007 0.0443 0.0443
Entamoeba histolytica protein kinase domain containing protein 0.0021 0.0062 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0394 0.0394
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Onchocerca volvulus 0.0061 0.0369 0.0316
Echinococcus granulosus tyrosine protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis c src tyrosine kinase 0.0153 0.1078 0.1078
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0068 0.0068
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.1283 0.983 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0088 0.0451
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Giardia lamblia PHD finger protein 15 0.003 0.0126 0.0128
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0068 0.0068
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0021 0.0061 0.0062
Echinococcus granulosus fch and double sh3 domains protein 2 0.0061 0.0369 0.0369
Echinococcus granulosus natriuretic peptide receptor 1 0.0021 0.0061 0.0061
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0021 0.0061 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0068 0.0069
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Loa Loa (eye worm) RNA binding protein 0.0064 0.0394 0.0502
Onchocerca volvulus 0.007 0.0443 0.0391
Echinococcus multilocularis musashi 0.0028 0.0117 0.0117
Echinococcus multilocularis purine nucleoside phosphorylase 0.1017 0.7773 0.7773
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0036 0.0179 0.0179
Echinococcus granulosus snurportin 1 0.0325 0.241 0.241
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0058 0.0059
Leishmania major hypothetical protein, conserved 0.0061 0.0369 0.1889
Loa Loa (eye worm) hypothetical protein 0.0036 0.0177 0.0223
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Leishmania major trypanothione reductase 0.0038 0.0194 0.0992
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0394 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Onchocerca volvulus 0.0028 0.0117 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0166
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0075 0.048 0.048
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0062 0.0317
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus intersectin 2 0.0062 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Schistosoma mansoni growth factor receptor-bound protein 0.0131 0.0915 0.0915
Echinococcus granulosus tyrosine protein kinase csk 0.0021 0.0061 0.0061
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Src64B 0.0614 0.4648 0.4648
Brugia malayi nuclear receptor NHR-88 0.0022 0.0068 0.0069
Entamoeba histolytica BAR/SH3 domain containing protein 0.0061 0.0369 0.0864
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0061 0.0074
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0266 0.1954 1
Echinococcus granulosus muscleblind protein 0.0316 0.2346 0.2346
Schistosoma mansoni cpg binding protein 0.0097 0.0647 0.0647
Loa Loa (eye worm) STAT protein 0.007 0.0443 0.0566
Plasmodium falciparum phd finger protein, putative 0.003 0.0126 0.0646
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0068 0.0068
Echinococcus multilocularis serine threonine protein kinase 0.0039 0.02 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Brugia malayi protein-tyrosine kinase 0.0061 0.0369 0.0376
Schistosoma mansoni formin binding protein and related proteins 0.0061 0.0369 0.0369
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0266 0.1954 0.5304
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0133 0.0679
Echinococcus multilocularis natriuretic peptide receptor 1 0.0021 0.0061 0.0061
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0215 0.0215
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0003 0.0003
Brugia malayi TAR-binding protein 0.0064 0.0394 0.0401
Echinococcus granulosus protein kinase C gamma type 0.0039 0.02 0.02
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0068 0.0007
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0025 0.0088 0.0076
Echinococcus multilocularis importin subunit beta 1 0.003 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Schistosoma mansoni ran 0.0022 0.007 0.007
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0072
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0068 0.0069
Brugia malayi ephrin receptor 1 precursor 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Loa Loa (eye worm) TK/EPH protein kinase 0.0021 0.0061 0.0074
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0237 0.0237
Schistosoma mansoni intermediate filament proteins 0.0028 0.0117 0.0117
Schistosoma mansoni vav2 0.0075 0.048 0.048
Plasmodium vivax tyrosine kinase-like protein, putative 0.0021 0.0061 0.0311
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0021 0.0061 0.0061
Toxoplasma gondii protein kinase 0.0021 0.0061 0.0311
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Echinococcus multilocularis endophilin A3 0.0061 0.0369 0.0369
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0086
Schistosoma mansoni shc transforming protein 0.007 0.0443 0.0443
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0237 0.0237
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Echinococcus multilocularis activated cdc42 kinase 1 0.0021 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Schistosoma mansoni tyrosine-protein kinase zap-70 0.007 0.0443 0.0443
Schistosoma mansoni cpg binding protein 0.0097 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0051 0.029 0.0368
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0068 0.0069
Loa Loa (eye worm) protein-tyrosine phosphatase 0.007 0.0443 0.0566
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0215 0.0215
Trichomonas vaginalis p67phox protein, putative 0.0061 0.0369 0.0376
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Schistosoma mansoni importin beta-1 0.003 0.0133 0.0133
Brugia malayi hypothetical protein 0.0036 0.0179 0.0182
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0072
Brugia malayi hypothetical protein 0.0092 0.0607 0.0617
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0553 0.4176 0.4176
Echinococcus multilocularis 0.0037 0.0181 0.0181
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0063 0.0385 0.0385
Schistosoma mansoni lamin 0.0028 0.0117 0.0117
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0021 0.0061 0.0062
Echinococcus multilocularis receptor type guanylyl cyclase 0.0021 0.0061 0.0061
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0349 0.0444
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0266 0.1954 0.1988
Brugia malayi Variant SH3 domain containing protein 0.0131 0.0915 0.0931
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0131 0.0915 0.0915
Brugia malayi SH2 domain containing protein 0.0092 0.0607 0.0617
Echinococcus multilocularis heat shock protein 70 0.0021 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Lyn 0.0614 0.4649 0.4649
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Echinococcus granulosus activin receptor type 0.0021 0.0062 0.0062
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Schistosoma mansoni uridine phosphorylase 0.0266 0.1954 0.1954
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Echinococcus multilocularis tyrosine protein kinase Abl 0.0153 0.1078 0.1078
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Brugia malayi Tyrosine-protein kinase PR2 0.0021 0.0061 0.0062
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0061 0.0369 0.0369
Echinococcus granulosus src region 0.0061 0.0369 0.0369
Onchocerca volvulus 0.0061 0.0369 0.0316
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0369 0.0376
Brugia malayi Protein kinase c protein 2 0.0037 0.0186 0.0189
Toxoplasma gondii histone lysine methyltransferase SET1 0.0174 0.1241 0.6352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus granulosus RNA directed DNA polymerase 0.0031 0.014 0.014
Onchocerca volvulus 0.0092 0.0607 0.0559
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Plasmodium vivax protein kinase, putative 0.0021 0.0061 0.0311
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0647 0.0647
Echinococcus multilocularis tyrosine protein kinase csk 0.0021 0.0061 0.0061
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0198 0.0198
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0266 0.1954 0.1988
Brugia malayi C-terminal src kinase protein 1 0.0021 0.0061 0.0062
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0061 0.0369 0.0369
Echinococcus multilocularis protein tyrosine kinase 0.0021 0.0061 0.0061
Schistosoma mansoni suppressor of cytokine signaling 0.007 0.0443 0.0443
Schistosoma mansoni SH2A 0.007 0.0443 0.0443
Echinococcus granulosus expressed conserved protein 0.007 0.0443 0.0443
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0021 0.0061 0.0061
Echinococcus multilocularis dnaJ subfamily B 0.1305 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0061 0.0369 0.0471
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0021 0.0061 0.0311
Echinococcus granulosus purine nucleoside phosphorylase 0.1283 0.983 0.983
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0493 0.0493
Schistosoma mansoni signal transduction protein lnk-related 0.007 0.0443 0.0443
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0021 0.0061 0.0061
Plasmodium falciparum importin beta, putative 0.003 0.0133 0.0679
Echinococcus multilocularis SH2 motif 0.007 0.0443 0.0443
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0061 0.0369 0.0369
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0548 0.0548
Onchocerca volvulus 0.011 0.0746 0.0701
Echinococcus granulosus tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Loa Loa (eye worm) TK/ABL protein kinase 0.0092 0.0607 0.0776
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0068 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Schistosoma mansoni cpg binding protein 0.0092 0.0607 0.0607
Echinococcus multilocularis epidermal growth factor receptor 0.0139 0.0973 0.0973
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0394 0.0401
Echinococcus granulosus tyrosine kinase 0.0092 0.0607 0.0607
Loa Loa (eye worm) TK/Met protein kinase 0.0021 0.0061 0.0074
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0126 0.0126
Echinococcus granulosus raf serine:threonine protein kinase 0.0026 0.0098 0.0098
Trypanosoma brucei Pseudokinase, putative 0.0021 0.0061 0.0311
Brugia malayi Variant SH3 domain containing protein 0.0075 0.048 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0021 0.0061 0.0074
Brugia malayi Tensin 0.007 0.0443 0.0451
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.1017 0.7773 0.7773
Loa Loa (eye worm) hypothetical protein 0.0316 0.2346 0.3015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0015 0.0015
Echinococcus granulosus hypothetical protein 0.007 0.0443 0.0443
Echinococcus granulosus ephrin type A receptor 4 A 0.0021 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0614 0.4648 0.4648
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0021 0.0061 0.0061
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0071 0.0451 0.0576
Schistosoma mansoni nck2/grb4 0.0131 0.0915 0.0915
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0032 0.0149 0.0187
Echinococcus multilocularis FL cytokine receptor 0.0021 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0092 0.0607 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0068 0.0082
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0361
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0061 0.0369 0.0369
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0266 0.1954 0.251
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0349 0.0349
Schistosoma mansoni tyrosine kinase 0.0614 0.4648 0.4648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Echinococcus granulosus microtubule associated protein 2 0.0699 0.5306 0.5306
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0061 0.0074
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Onchocerca volvulus 0.0092 0.0607 0.0559
Onchocerca volvulus 0.0092 0.0607 0.0559
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0036 0.0179 0.0332
Schistosoma mansoni tyrosine kinase 0.0063 0.0385 0.0385
Mycobacterium tuberculosis Hypothetical protein 0.0266 0.1954 0.1988
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Schistosoma mansoni tyrosine kinase 0.0084 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0531 0.4012 0.4012
Schistosoma mansoni ephrin receptor 0.0021 0.0061 0.0061
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0126 0.0158
Loa Loa (eye worm) thyroid receptor interactor 0.0061 0.0369 0.0471
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis protein tyrosine kinase, putative 0.0021 0.0061 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis Spectrin alpha actinin 0.0061 0.0369 0.0369
Giardia lamblia Kinase, NEK 0.0021 0.0061 0.0062
Echinococcus granulosus SH2 motif 0.007 0.0443 0.0443
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0131 0.0915 0.1173
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0061 0.0369 0.0369
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Loa Loa (eye worm) serine/threonine protein kinase 0.0021 0.0061 0.0074
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Onchocerca volvulus 0.0061 0.037 0.0317
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Echinococcus multilocularis peregrin 0.003 0.0126 0.0126
Onchocerca volvulus 0.007 0.0443 0.0391
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.0369 0.0864
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.007 0.0361
Brugia malayi Peripheral plasma membrane protein CASK 0.0061 0.0369 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Loa Loa (eye worm) TK/CSK protein kinase 0.0021 0.0061 0.0074
Echinococcus granulosus tyrosine protein kinase ABL1 0.0092 0.0607 0.0607
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.1283 0.983 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.1954 0.1988
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.037 0.0472
Loa Loa (eye worm) TK protein kinase 0.0021 0.0061 0.0074
Onchocerca volvulus Putative cortactin 0.0061 0.0369 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0369 0.1889
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0574 0.0584
Echinococcus multilocularis tyrosine kinase 0.0092 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Echinococcus multilocularis tyrosine protein kinase shark 0.0429 0.3218 0.3218
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0068 0.0068
Echinococcus multilocularis geminin 0.0352 0.262 0.262
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0266 0.1954 0.5304
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0194 0.0245
Echinococcus granulosus tyrosine protein kinase csk 0.0021 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni hypothetical protein 0.1305 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0068 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0073 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0068 0.0068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0068 0.0068
Schistosoma mansoni GTPase activating protein 0.007 0.0443 0.0443
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.5306 0.5306
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Onchocerca volvulus 0.0092 0.0607 0.0559
Echinococcus multilocularis NCK adaptor protein 0.0131 0.0915 0.0915
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0153 0.1078 0.1078
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi bone morphogenetic protein type 1 receptor 0.0021 0.0061 0.0062
Brugia malayi SRC-1 0.0614 0.4648 0.4728
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0023 0.0075 0.0075
Entamoeba histolytica BAR/SH3 domain containing protein 0.0061 0.0369 0.0864
Loa Loa (eye worm) guanylate kinase 0.0061 0.0369 0.0471
Leishmania major GTP-binding protein, putative 0.0022 0.007 0.0361
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus granulosus Spectrin alpha actinin 0.0061 0.0369 0.0369
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0061 0.0369 0.0369
Schistosoma mansoni dreadlocks/dock 0.0061 0.0369 0.0369
Giardia lamblia Protein 21.1 0.0021 0.0061 0.0062
Schistosoma mansoni dynamin-associated protein 0.0061 0.0369 0.0369
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0614 0.4648 0.4648
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0073 0.0073
Plasmodium falciparum tyrosine kinase-like protein 0.0021 0.0061 0.0311
Loa Loa (eye worm) TK/FAK protein kinase 0.0021 0.0061 0.0074
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0117 0.0147
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0075 0.048 0.048
Echinococcus multilocularis SH2 domain containing protein 7 0.007 0.0443 0.0443
Loa Loa (eye worm) TK protein kinase 0.0482 0.363 0.4668
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Loa Loa (eye worm) hypothetical protein 0.0316 0.2346 0.3015
Brugia malayi RNA, U transporter 1 0.0086 0.0567 0.0576
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0021 0.0061 0.0061
Echinococcus granulosus epidermal growth factor receptor kinase 0.0061 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.1017 0.7773 1
Leishmania major methylthioadenosine phosphorylase, putative 0.0266 0.1954 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0068 0.0069
Plasmodium falciparum tyrosine kinase-like protein 0.0021 0.0061 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0068 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Echinococcus multilocularis tyrosine kinase 0.0021 0.0061 0.0061
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0451 0.0458
Schistosoma mansoni hypothetical protein 0.007 0.0443 0.0443
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Echinococcus multilocularis muscleblind protein 1 0.0316 0.2346 0.2346
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0061 0.0369 0.1889
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0092 0.0607 0.0607
Echinococcus multilocularis tyrosine protein kinase csk 0.0021 0.0061 0.0061
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0061 0.0074
Echinococcus multilocularis tyrosine protein kinase pr2 0.0021 0.0061 0.0061
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Echinococcus multilocularis growth factor receptor bound protein 2 0.0131 0.0915 0.0915
Trichomonas vaginalis protein kinase atn1, putative 0.0021 0.0061 0.0062
Echinococcus granulosus protein tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0021 0.0061 0.0061
Trypanosoma cruzi protein kinase, putative 0.0021 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Schistosoma mansoni hypothetical protein 0.0352 0.262 0.262
Echinococcus granulosus lamin dm0 0.0028 0.0117 0.0117
Schistosoma mansoni Dab2-interacting protein-like 0.0061 0.0369 0.0369
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0062 0.0317
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Echinococcus granulosus endophilin A3 0.0061 0.0369 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0058 0.0059
Echinococcus multilocularis kinase suppressor of Ras 1 0.0021 0.0061 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0061 0.0062
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0574 0.0584
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0061 0.0369 0.0369
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0021 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0036 0.0179 0.0332
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Brugia malayi STAT protein, DNA binding domain containing protein 0.007 0.0443 0.0451
Leishmania major nucleoside phosphorylase-like protein 0.0266 0.1954 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0021 0.0061 0.0074
Loa Loa (eye worm) p53BP2 0.0061 0.0369 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0394 0.0394
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0325 0.241 0.241
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0021 0.0061 0.0074
Schistosoma mansoni tensin 0.007 0.0443 0.0443
Schistosoma mansoni tyrosine kinase 0.0058 0.0349 0.0349
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0021 0.0061 0.0074
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus granulosus importin subunit beta 1 0.003 0.0133 0.0133
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0021 0.0062 0.0317
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0548 0.0548
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0361
Echinococcus granulosus cpg binding protein 0.0097 0.0647 0.0647
Plasmodium falciparum purine nucleoside phosphorylase 0.0266 0.1954 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0369 0.0376
Echinococcus granulosus tensin 0.007 0.0443 0.0443
Echinococcus granulosus tyrosine kinase 0.0553 0.4176 0.4176
Treponema pallidum uridine phosphorylase (udp) 0.0266 0.1954 1
Trichomonas vaginalis ran, putative 0.0022 0.007 0.0072
Loa Loa (eye worm) SH2 domain-containing protein 0.007 0.0443 0.0566
Giardia lamblia Kinase, NEK 0.0021 0.0061 0.0062
Plasmodium vivax glutathione reductase, putative 0.0038 0.0194 0.0992
Brugia malayi Immunoglobulin I-set domain containing protein 0.0141 0.0985 0.1003
Echinococcus granulosus tar DNA binding protein 0.0064 0.0394 0.0394
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0058 0.0059
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0574 0.0584
Leishmania major hypothetical protein, conserved 0.0021 0.0061 0.0311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0074
Schistosoma mansoni hypothetical protein 0.0352 0.262 0.262
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0369 0.1889
Echinococcus multilocularis SH2 domain containing adapter protein F 0.007 0.0443 0.0443
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0194 0.0992
Schistosoma mansoni sorbin 0.0061 0.0369 0.0369
Mycobacterium ulcerans purine nucleoside phosphorylase 0.1283 0.983 1
Schistosoma mansoni tyrosine kinase 0.0021 0.0061 0.0061
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0198 0.0198
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Brugia malayi SH2 domain containing protein 0.007 0.0443 0.0451
Brugia malayi Protein kinase domain containing protein 0.0058 0.0349 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0061 0.0062
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0061 0.0369 0.0369
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0075 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Echinococcus multilocularis purine nucleoside phosphorylase 0.1283 0.983 0.983
Schistosoma mansoni hypothetical protein 0.007 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.007 0.0443 0.0566
Echinococcus multilocularis tyrosine protein kinase Blk 0.0553 0.4176 0.4176
Echinococcus multilocularis protein kinase 0.0021 0.0061 0.0061
Echinococcus multilocularis suppressor of cytokine signaling 7 0.007 0.0443 0.0443
Entamoeba histolytica hypothetical protein 0.0061 0.0369 0.0864
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0015 0.0078
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0649 0.066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0147
Leishmania major protein kinase, putative 0.0021 0.0061 0.0311
Onchocerca volvulus 0.007 0.0443 0.0391
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0068 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0021 0.0061 0.0062
Schistosoma mansoni tyrosine kinase 0.0139 0.0973 0.0973
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0614 0.4648 0.4648
Brugia malayi uridine phosphorylase family protein 0.0266 0.1954 0.1988
Echinococcus granulosus retinal guanylyl cyclase 2 0.0021 0.0061 0.0061
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0266 0.1954 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0061 0.0062
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.007 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0061 0.0369 0.0471
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0614 0.4648 0.4648
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.1283 0.983 1
Loa Loa (eye worm) TK/FER protein kinase 0.0092 0.0607 0.0776

Activities

Activity type Activity value Assay description Source Reference
Hematotoxicity (functional) = 25 % Compound was tested for hematotoxicity and the number of peripheral platelets of normal mice on day 7 (percent of control) was determined, expressed as percent of control ChEMBL. 10052974
Hematotoxicity (functional) = 44 % Compound was tested for hematotoxicity and the number of white blood cells of tumor bearing mice on day 4(percent of control) was determined, expressed as percent of control ChEMBL. 10052974
IC50 (functional) = 37 nM Compound was tested in vitro for anticellular activity against HeLa S3 cell growth at 72-hour exposure. ChEMBL. 10052974
IC50 (functional) = 1800 nM Compound was tested in vitro for anticellular activity against HeLa S3 cell growth at 1-hour exposure. ChEMBL. 10052974

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10052974

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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