TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.459 | Formula: C20H26N6O2
H donors: 2 H acceptors: 1 LogP: 1.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)Cc1[nH]c2c(c1)c(=O)[nH]c(n2)N(C)C
InChi: 1S/C20H26N6O2/c1-24(2)20-22-18-15(19(27)23-20)12-14(21-18)13-25-8-10-26(11-9-25)16-6-4-5-7-17(16)28-3/h4-7,12H,8-11,13H2,1-3H3,(H2,21,22,23,27)
InChiKey: OIAXKPXJNIOPBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Dopamine D1 receptor	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D3	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D4	Starlite/ChEMBL	References
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	5-hydroxytryptamine receptor 1, putative	Get druggable targets OG5_132667	All targets in OG5_132667
Schistosoma japonicum	5-hydroxytryptamine receptor, putative	Get druggable targets OG5_132667	All targets in OG5_132667

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	dopamine receptor D3	400 aa	392 aa	19.9 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Dopamine D1 receptor	446 aa	398 aa	33.9 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Dopamine D1 receptor	446 aa	393 aa	32.3 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Dopamine D1 receptor	446 aa	371 aa	34.5 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Dopamine D1 receptor	446 aa	373 aa	27.1 %
Loa Loa (eye worm)	hypothetical protein	Dopamine D1 receptor	446 aa	370 aa	24.3 %
Onchocerca volvulus		Dopamine D1 receptor	446 aa	359 aa	21.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0015	0.0048	0.011
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0124	0.0121
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	0.0295
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0124	0.012
Schistosoma mansoni	neuropeptide receptor	0.003	0.0124	0.0121
Entamoeba histolytica	hypothetical protein	0.0062	0.0279	0.0275
Onchocerca volvulus		0.003	0.0124	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0051	0.0227	0.0223
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0124	0.012
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0124	0.0121
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0124	0.0121
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.2027	1	1
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0008	0.0004
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0021	0.0077	0.1543
Leishmania major	cytochrome p450-like protein	0.0022	0.0084	0.008
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	acetyltransferase	0.0122	0.0577	0.0573
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0124	0.0121
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2027	1	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0032	0.0131	0.0127
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	g protein coupled receptor	0.003	0.0124	0.0121
Schistosoma mansoni	transcription factor LCR-F1	0.0062	0.0279	0.0276
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0036	0.0151	0.015
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0124	0.0121
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	putative neuropeptide receptor	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Onchocerca volvulus		0.003	0.0124	1
Onchocerca volvulus		0.003	0.0124	1
Brugia malayi	AKH receptor	0.003	0.0124	0.012
Schistosoma mansoni	hypothetical protein	0.003	0.0124	0.0121
Brugia malayi	neuropeptide F receptor	0.003	0.0124	0.012
Echinococcus granulosus	orexin receptor type 2	0.003	0.0124	0.0121
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.2027	1	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0023	0.0086	0.0082
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0039
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0006	0.0004	0.001
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0015	0.0048	0.01
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0124	0.0121
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0036	0.0151	0.0147
Brugia malayi	cytochrome P450	0.0015	0.0048	0.0044
Leishmania major	cytochrome p450-like protein	0.0015	0.0048	0.0044
Brugia malayi	G protein-coupled receptor	0.003	0.0124	0.012
Onchocerca volvulus		0.003	0.0124	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0007	0.0008	0.0004
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0015	0.0048	0.01
Loa Loa (eye worm)	transcription factor SMAD2	0.01	0.0471	0.0467
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0015	0.0048	0.011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0124	0.0121
Schistosoma mansoni	microtubule-associated protein tau	0.0593	0.2906	0.2903
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0042	0.0038
Echinococcus granulosus	hypothetical protein	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0124	0.0121
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0077	0.0072
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0124	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Schistosoma mansoni	hypothetical protein	0.0015	0.0048	0.0044
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0039	0.0168	0.0164
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0124	0.0121
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0168	0.0165
Onchocerca volvulus		0.003	0.0124	1
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0885	0.4351	1
Loa Loa (eye worm)	Smad1	0.0007	0.0008	0.0004
Echinococcus granulosus	neuropeptide receptor	0.003	0.0124	0.0121
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0032	0.0131	0.0127
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0015	0.0048	0.01
Brugia malayi	G-protein coupled receptor	0.003	0.0124	0.012
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0015	0.0048	0.01
Brugia malayi	acetyltransferase, GNAT family protein	0.0122	0.0577	0.0573
Onchocerca volvulus		0.003	0.0124	1
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2027	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0124	0.012
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0006	0.0004	0.001
Schistosoma mansoni	neuropeptide receptor	0.003	0.0124	0.0121
Echinococcus granulosus	cytochrome P450 2K1	0.0015	0.0048	0.0044
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2027	1	1
Onchocerca volvulus		0.003	0.0124	1
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0072
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0014	0.0042	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium leprae	putative cytochrome p450	0.0015	0.0048	0.0929
Echinococcus granulosus	cpg binding protein	0.0026	0.01	0.0097
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0032	0.0131	0.0127
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	Thioredoxin reductase	0.004	0.0171	0.0167
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0011	0.0006
Onchocerca volvulus		0.003	0.0124	1
Onchocerca volvulus		0.003	0.0124	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0032	0.0131	0.0127
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0032	0.0131	0.0127
Onchocerca volvulus		0.003	0.0124	1
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0084	0.008
Schistosoma mansoni	adenoreceptor	0.003	0.0124	0.0121
Echinococcus multilocularis	serotonin receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0168	0.0165
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0077	0.0072
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0015	0.0048	0.01
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2027	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0101	0.0473	0.1087
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0015	0.0048	0.011
Echinococcus granulosus	Smad4	0.0007	0.0008	0.0004
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0131	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0015	0.0048	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0062	0.0279	0.0276
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0015	0.0048	0.01
Brugia malayi	Dopamine receptor protein 2	0.003	0.0124	0.012
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0124	0.0121
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0124	0.0121
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Onchocerca volvulus		0.003	0.0124	1
Brugia malayi	sulfakinin receptor protein	0.003	0.0124	0.012
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.0423	0.0972
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0051	0.0228	0.0224
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.0423	0.0972
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0171	0.0167
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0171	0.0167
Entamoeba histolytica	hypothetical protein	0.0062	0.0279	0.0275
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0048	0.0044
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	0.0679
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0124	0.012
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0094	0.0089
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0124	0.012
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0011	0.0007
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0168	0.0165
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0015	0.0048	0.011
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0124	0.0121
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0086	0.0082
Schistosoma mansoni	neuropeptide receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0021	0.0077	0.1543
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0101	0.0473	0.1087
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0015	0.0051	0.0107
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0015	0.0048	0.01
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0006	0.0004	0.001
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0007	0.0008	0.0004
Brugia malayi	Melatonin receptor type 1A	0.003	0.0124	0.012
Brugia malayi	RE15519p	0.003	0.0124	0.012
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0021	0.0077	0.0166
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0084	0.008
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0124	0.012
Trichomonas vaginalis	mercuric reductase, putative	0.0014	0.0042	0.0041
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0124	1
Brugia malayi	GnHR receptor homolog	0.003	0.0124	0.012
Echinococcus multilocularis	dnaJ subfamily B	0.0344	0.1676	0.1673
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0168	0.0165
Mycobacterium tuberculosis	Probable reductase	0.0091	0.0423	0.0972
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0007	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus multilocularis	somatostatin receptor	0.003	0.0124	0.0121
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0032	0.0131	0.0127
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0021	0.0077	0.0176
Echinococcus granulosus	peptidase Clp S14 family	0.0043	0.0187	0.0184
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2027	1	1
Entamoeba histolytica	hypothetical protein	0.0062	0.0279	0.0275
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0008	0.0004
Brugia malayi	ORL1-like opioid receptor	0.003	0.0124	0.012
Schistosoma mansoni	amine GPCR	0.003	0.0124	0.0121
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0084	0.008
Schistosoma mansoni	smad1 5 8 and	0.0007	0.0008	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0014	0.0042	0.0088
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0014	0.0042	0.0097
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0124	0.0121
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0032	0.0131	0.013
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0124	0.0121
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0077	0.0072
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0015	0.0048	0.01
Echinococcus granulosus	serotonin receptor	0.003	0.0124	0.0121
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0023	0.0086	0.175
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0014	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	Serotonin receptor	0.003	0.0124	0.012
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	ubiquitin specific protease 41	0.0032	0.0131	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0015	0.0048	0.011
Echinococcus granulosus	ubiquitin specific protease 41	0.0032	0.0131	0.0127
Schistosoma mansoni	biogenic amine receptor	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0015	0.0048	0.011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0046	0.0107
Entamoeba histolytica	acetyltransferase, GNAT family	0.0033	0.0137	0.0133
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0124	0.0121
Leishmania major	cytochrome p450-like protein	0.0015	0.0048	0.0044
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0124	0.0121
Plasmodium falciparum	glutathione reductase	0.0014	0.0042	0.0038
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0015	0.0048	0.01
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0015	0.0048	0.0044
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	1
Loa Loa (eye worm)	glutathione reductase	0.004	0.0171	0.0167
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0124	0.0121
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0124	0.012
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0006	0.0004	0.001
Trichomonas vaginalis	antibiotic synthetase, putative	0.0006	0.0004	0.0003
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0015	0.0048	0.01
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0046	0.0107
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0124	0.0121
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0168	0.0165
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0015	0.0051	0.0116
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0042	0.0038
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0124	0.012
Echinococcus multilocularis	serotonin receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0077	0.0176
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0039	0.0168	0.0164
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Brugia malayi	MH2 domain containing protein	0.0007	0.0008	0.0004
Brugia malayi	neuropeptide F receptor	0.003	0.0124	0.012
Plasmodium vivax	glutathione reductase, putative	0.004	0.0171	0.0167
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0066	0.03	0.0296
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0122	0.0577	0.0574
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0077	0.0072
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2027	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0021	0.0077	0.0072
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0124	0.0121
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0004	0.001
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0024	0.002
Mycobacterium ulcerans	hypothetical protein	0.0885	0.4351	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0124	0.0121
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Echinococcus granulosus	g protein coupled receptor	0.003	0.0124	0.0121
Onchocerca volvulus		0.003	0.0124	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0039
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0015	0.0048	0.0044
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0124	0.012
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0007	0.0008	0.0004
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0124	0.012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0007	0.0008	0.0004
Schistosoma mansoni	cpg binding protein	0.0026	0.01	0.0097
Brugia malayi	larval opioid receptor	0.003	0.0124	0.012
Brugia malayi	MH2 domain containing protein	0.0007	0.0008	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0124	0.012
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0006	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0046
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0015	0.0048	0.011
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0124	0.0121
Brugia malayi	MH1 domain containing protein	0.0007	0.0008	0.0004
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0004	0.001
Brugia malayi	Dopamine receptor protein 1	0.003	0.0124	0.012
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0021	0.0077	0.0072
Schistosoma mansoni	biogenic amine receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0046
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0015	0.0048	0.011
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0021	0.0077	0.0166
Plasmodium falciparum	thioredoxin reductase	0.004	0.0171	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Schistosoma mansoni	smad	0.0007	0.0008	0.0004
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0015	0.0048	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Echinococcus multilocularis	Smad4	0.0007	0.0008	0.0004
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0039
Toxoplasma gondii	aldehyde dehydrogenase	0.0051	0.0227	0.0223
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0227	0.0512
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0124	0.0121
Onchocerca volvulus		0.0021	0.0077	0.602
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.2027	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0124	1
Schistosoma mansoni	amine GPCR	0.003	0.0124	0.0121
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0124	0.0121
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0168	0.0165
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0046	0.0107
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0077	0.0072
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0046	0.0107
Loa Loa (eye worm)	histone methyltransferase	0.0007	0.0011	0.0007
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0066	0.03	0.0296
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0171	0.0167
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	smad	0.0007	0.0008	0.0004
Loa Loa (eye worm)	MH1 domain-containing protein	0.0007	0.0008	0.0004
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0124	0.0121
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0014	0.0042	0.0038
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0015	0.0048	0.01
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	1
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0015	0.0048	0.01
Echinococcus granulosus	microtubule associated protein 2	0.0593	0.2906	0.2903
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0124	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Trichomonas vaginalis	glutathione reductase, putative	0.0014	0.0042	0.0041
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0014	0.0042	0.0038
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0046
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0011	0.0006
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0032	0.0131	0.0089
Leishmania major	trypanothione reductase	0.004	0.0171	0.0167
Schistosoma mansoni	neuropeptide receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0124	0.0121
Echinococcus granulosus	fmrfamide receptor	0.003	0.0124	0.0121
Entamoeba histolytica	hypothetical protein	0.0062	0.0279	0.0275
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0032	0.0131	0.013
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0015	0.0048	0.01
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.2027	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0015	0.0048	0.01
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.0171	0.0393
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0015	0.0048	0.01
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0171	0.0167
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0066	0.03	0.6299
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	0.0679
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0077	0.0166
Brugia malayi	Cytochrome P450 family protein	0.0047	0.0207	0.0202
Toxoplasma gondii	hypothetical protein	0.0023	0.0086	0.0082
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2027	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0021	0.0077	0.0072
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0015	0.0048	0.01
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	MH2 domain-containing protein	0.01	0.0471	0.0467
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.0207	0.0202
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.2027	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0171	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0066	0.03	0.0295
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0014	0.0042	0.0038
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0051	0.0227	0.0223
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0032	0.0131	0.0127
Schistosoma mansoni	cytochrome P450	0.0015	0.0048	0.0044
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0015	0.0048	0.011
Schistosoma mansoni	opsin-like receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Brugia malayi	G-protein coupled receptor	0.003	0.0124	0.012
Schistosoma mansoni	hypothetical protein	0.0062	0.0279	0.0276
Onchocerca volvulus		0.003	0.0124	1
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0124	0.0121
Echinococcus granulosus	somatostatin receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0.0084	0.0184
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0015	0.0048	0.011
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0124	0.0121
Schistosoma mansoni	biogenic amine receptor	0.003	0.0124	0.0121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0077	0.0166
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0066	0.03	0.0295
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0038
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0049	0.0215	0.0211
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0004	0.001
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0043	0.0187	0.0431
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0006	0.0004	0.001
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0227	0.0223
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0015	0.0048	0.01
Echinococcus granulosus	neuropeptide receptor	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0015	0.0048	0.011
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0124	0.012
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0084	0.008
Echinococcus granulosus	mothers against decapentaplegic 5	0.0007	0.0008	0.0004
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0032	0.0131	0.0127
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Plasmodium vivax	acyl-CoA synthetase, putative	0.0015	0.0051	0.0046
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0015	0.0048	0.011
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0124	0.0121
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0124	0.012
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0015	0.0048	0.01
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0124	0.0121
Trichomonas vaginalis	antibiotic synthetase, putative	0.0006	0.0004	0.0003
Plasmodium falciparum	acyl-CoA synthetase	0.0015	0.0051	0.0046
Trypanosoma cruzi	trypanothione reductase, putative	0.0014	0.0042	0.0038
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0015	0.0048	0.01
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0036	0.0151	0.0147
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.0423	0.0972
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0124	0.0121
Schistosoma mansoni	amine GPCR	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0015	0.0048	0.011
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0062	0.0279	0.0276
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0015	0.0048	0.01
Echinococcus multilocularis	smad	0.0007	0.0008	0.0004
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0066	0.03	0.0295
Schistosoma mansoni	histamine h1 receptor	0.003	0.0124	0.0121
Onchocerca volvulus		0.003	0.0124	1
Trypanosoma brucei	cytochrome P450, putative	0.0022	0.0084	0.008
Brugia malayi	MH1 domain containing protein	0.0007	0.0008	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Plasmodium falciparum	histone acetyltransferase GCN5	0.0033	0.0137	0.0133
Onchocerca volvulus		0.003	0.0124	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0227	0.0512
Plasmodium falciparum	glutathione reductase	0.004	0.0171	0.0167
Echinococcus granulosus	sex peptide receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Plasmodium falciparum	thioredoxin reductase	0.0014	0.0042	0.0038
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0119	0.056	0.0557
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0124	0.012
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0015	0.0048	0.011
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0124	0.0121
Toxoplasma gondii	thioredoxin reductase	0.004	0.0171	0.0167
Brugia malayi	Probable ClpP-like protease	0.0066	0.03	0.0295
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0014	0.0042	0.0088
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0091	0.0423	0.8932
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0051	0.0227	0.0521
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0015	0.0048	0.0044
Brugia malayi	Serotonin receptor	0.003	0.0124	0.012
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.0423	0.0972
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0032	0.0131	0.0127
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0124	0.012
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0124	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0168	0.0165
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0084	0.008
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0227	0.0223
Loa Loa (eye worm)	CYP4Cod1	0.0022	0.0084	0.008
Echinococcus multilocularis	sex peptide receptor	0.003	0.0124	0.0121
Mycobacterium leprae	Conserved hypothetical protein	0.0015	0.0048	0.0929
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0124	0.0121
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0014	0.0042	0.0038
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Toxoplasma gondii	NADPH-glutathione reductase	0.0014	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0124	0.0121
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0014	0.0042	0.0038
Trypanosoma brucei	trypanothione reductase	0.004	0.0171	0.0167
Schistosoma mansoni	cpg binding protein	0.0026	0.01	0.0097
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0124	0.012
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0014	0.0042	0.0038
Schistosoma mansoni	hypothetical protein	0.003	0.0124	0.0121
Echinococcus multilocularis		0.2027	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0072
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0124	0.012
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	cpg binding protein	0.0026	0.01	0.0097
Schistosoma mansoni	amine GPCR	0.003	0.0124	0.0121
Schistosoma mansoni	amine GPCR	0.003	0.0124	0.0121
Schistosoma mansoni	opsin-like receptor	0.003	0.0124	0.0121
Schistosoma mansoni	peptidase Clp (S14 family)	0.0066	0.03	0.0296
Schistosoma mansoni	Smad4	0.0007	0.0008	0.0004
Schistosoma mansoni	hypothetical protein	0.0344	0.1676	0.1673
Schistosoma mansoni	cpg binding protein	0.0024	0.0094	0.009
Echinococcus granulosus	g protein coupled receptor	0.003	0.0124	0.0121
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0086	0.1708
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0042	0.0038
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0043	0.0187	0.0431
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0124	0.0121
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0006	0.0004	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0015	0.0048	0.0044
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0036	0.0151	0.015
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0124	0.0121
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0051	0.0227	0.0223
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0036	0.0151	0.0148
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2027	1	1
Brugia malayi	hypothetical protein	0.003	0.0124	0.012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0124	0.0121
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0024	0.002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0077	0.0166
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0015	0.0051	0.0323
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0077	0.0166
Loa Loa (eye worm)	cytochrome P450	0.0015	0.0048	0.0044
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0124	0.0121
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0124	0.0121
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0043	0.0187	0.0184
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Brugia malayi	hypothetical protein	0.0062	0.0279	0.0275
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0015	0.0048	0.0044
Schistosoma mansoni	hypothetical protein	0.003	0.0124	0.0121
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0015	0.0048	0.0044
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0124	0.0121
Brugia malayi	Smad1	0.0007	0.0008	0.0004
Brugia malayi	MH2 domain containing protein	0.01	0.0471	0.0467
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0014	0.0042	0.0038
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0124	0.0121
Echinococcus granulosus	allatostatin A receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0077	0.0166
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0043	0.0187	0.3908
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0124	0.012
Entamoeba histolytica	acyl-coA synthetase, putative	0.0021	0.0077	0.0072
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0077	0.0072
Echinococcus granulosus	dnaJ subfamily B	0.0344	0.1676	0.1673
Onchocerca volvulus		0.003	0.0124	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0032	0.0131	0.0127
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.2027	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0015	0.0048	0.011
Schistosoma mansoni	myosin xvIII	0.003	0.0124	0.0121
Echinococcus multilocularis	microtubule associated protein 2	0.0593	0.2906	0.2903
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0124	0.0121
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0036	0.0151	0.0147
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.0423	0.0972
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0124	0.0121
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0011	0.0007
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0014	0.0042	0.0088
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.2027	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0084	0.008
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0032	0.0131	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0015	0.0048	0.011
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0015	0.0048	0.011
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0046
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.012
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0124	0.0121
Brugia malayi	Dopamine receptor	0.003	0.0124	0.012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0066	0.03	1
Onchocerca volvulus		0.003	0.0124	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0033	0.0137	0.0095
Echinococcus multilocularis		0.0015	0.0048	0.0044
Onchocerca volvulus		0.0024	0.0094	0.7445
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0066	0.03	0.0295
Schistosoma mansoni	opsin-like receptor	0.003	0.0124	0.0121
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0051	0.0227	0.0512
Mycobacterium tuberculosis	Probable oxidoreductase	0.0101	0.0473	0.1087
Brugia malayi	glutathione reductase	0.004	0.0171	0.0167
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0077	0.0166
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0124	0.0121
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0094	0.0089
Schistosoma mansoni	hypothetical protein	0.003	0.0124	0.0121
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0101	0.0473	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0122	0.0577	0.0574
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0032	0.0131	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0015	0.0048	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0124	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0124	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0131	0.013
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0124	0.0121

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 0 %	Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cells at 100 nM	ChEMBL.	19481941
Activity (binding)	= 20 %	Displacement of [3H]SCH23390 from pig dopamine D1 receptor at 100 nM	ChEMBL.	19481941
Activity (binding)	= 20 %	Displacement of [3H]spiperone from human cloned dopamine D2 long receptor expressed in CHO cells at 100 nM	ChEMBL.	19481941
Activity (binding)	= 60 %	Displacement of [3H]spiperone from human cloned dopamine D4.4 receptor expressed in CHO cells at 100 nM	ChEMBL.	19481941
Ki (binding)	= 2.4 nM	Displacement of [3H]spiroperidol from human cloned dopamine D4.4 receptor expressed in CHO cells	ChEMBL.	19481941
Ki (binding)	= 130 nM	Displacement of [3H]SCH23390 from human cloned dopamine D2 long receptor expressed in CHO cells	ChEMBL.	19481941
Ki (binding)	= 170 nM	Displacement of [3H]spiroperidol from human cloned dopamine D2 short receptor expressed in CHO cells	ChEMBL.	19481941
Ki (binding)	= 960 nM	Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor expressed in CHO cells	ChEMBL.	19481941
Ki (binding)	= 8400 nM	Displacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL.	19481941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL552268

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1049871