Detailed information for compound 1063271

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.598 | Formula: C27H37F2N3O2
  • H donors: 4 H acceptors: 2 LogP: 4.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H]([C@@H](CNC1(CCCNC1)c1cccc(c1)C(C)(C)C)O)Cc1cc(F)cc(c1)F
  • InChi: 1S/C27H37F2N3O2/c1-18(33)32-24(13-19-11-22(28)15-23(29)12-19)25(34)16-31-27(9-6-10-30-17-27)21-8-5-7-20(14-21)26(2,3)4/h5,7-8,11-12,14-15,24-25,30-31,34H,6,9-10,13,16-17H2,1-4H3,(H,32,33)/t24-,25+,27?/m0/s1
  • InChiKey: ACQZNRIKGPGXLO-QDSWCARHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin D Starlite/ChEMBL References
Homo sapiens beta-site APP-cleaving enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative Get druggable targets OG5_135830 All targets in OG5_135830
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni memapsin-2 (A01 family) Get druggable targets OG5_135830 All targets in OG5_135830
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin X cathepsin D 412 aa 339 aa 28.9 %
Plasmodium falciparum plasmepsin VII beta-site APP-cleaving enzyme 1 401 aa 352 aa 21.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0029 0.0094
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0062 0.026
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0161 0.0555
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0029 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0156 0.0366
Plasmodium vivax importin-beta 2, putative 0.0028 0.0118 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0006
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0071 0.0167
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0323 0.0756
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0004
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0118 0.0325
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0029 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0327 0.1771
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0455 0.283 0.9492
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.007 0.0239
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0161 0.0555
Onchocerca volvulus 0.0061 0.0327 0.1092
Echinococcus multilocularis FTZ F1 alpha 0.002 0.007 0.0165
Mycobacterium ulcerans hypothetical protein 0.0455 0.283 0.7001
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0323 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.007 0.0239
Leishmania major DNA polymerase eta, putative 0.0019 0.0062 0.026
Echinococcus granulosus muscleblind protein 0.0452 0.281 0.6585
Mycobacterium ulcerans beta-lactamase 0.0248 0.1515 0.3674
Echinococcus multilocularis geminin 0.0337 0.2078 0.4871
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0156 0.0366
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0168 0.3069
Schistosoma mansoni inositol monophosphatase 0.0036 0.0168 0.0393
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0276 0.0647
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0461 0.1081
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0144 0.0146
Brugia malayi beta-lactamase family protein 0.0248 0.1515 0.5255
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.006 0.0323 0.1115
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0161 0.24
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0062 0.0131
Entamoeba histolytica hypothetical protein 0.0023 0.0084 0.0767
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0299 0.0701
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0299 0.0933
Mycobacterium tuberculosis Conserved protein 0.0248 0.1515 0.1462
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0161 0.0625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0327 0.0766
Leishmania major DNA polymerase kappa, putative 0.0019 0.0062 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0026
Schistosoma mansoni alpha glucosidase 0.0035 0.0163 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Schistosoma mansoni thyroid hormone receptor 0.002 0.007 0.0165
Brugia malayi MAP kinase sur-1 0.0057 0.0299 0.1033
Echinococcus granulosus GPCR family 2 0.0031 0.014 0.0328
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0248 0.1515 0.5255
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0065 0.0351 0.0731
Mycobacterium ulcerans esterase/lipase LipP 0.0248 0.1515 0.3674
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0463 0.2881 1
Trypanosoma cruzi hypothetical protein, conserved 0.0248 0.1515 1
Mycobacterium ulcerans hypothetical protein 0.0248 0.1515 0.3674
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.2017 0.4727
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0026
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0004
Leishmania major GTP-binding protein, putative 0.0021 0.0071 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0004
Echinococcus granulosus ornithine aminotransferase 0.0065 0.0351 0.0823
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0474
Loa Loa (eye worm) hypothetical protein 0.0452 0.281 0.9752
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0029 0.0069
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0029 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0029 0.0097
Echinococcus multilocularis Smad4 0.0017 0.0048 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.026
Onchocerca volvulus 0.0479 0.298 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0946 0.2217
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.026
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0065 0.0351 0.1939
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0023 0.0076
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0029 0.0097
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0071 0.0167
Loa Loa (eye worm) hypothetical protein 0.0452 0.281 0.9752
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.014 0.0328
Plasmodium falciparum importin beta, putative 0.0028 0.0118 0.1249
Mycobacterium tuberculosis Probable lipase LipE 0.0248 0.1515 0.1462
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.014 0.0481
Mycobacterium leprae conserved hypothetical protein 0.0248 0.1515 0.3635
Echinococcus multilocularis dna polymerase eta 0.0019 0.0062 0.0145
Brugia malayi Pre-SET motif family protein 0.0421 0.2612 0.9065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.1755
Brugia malayi hypothetical protein 0.0076 0.0421 0.1458
Mycobacterium tuberculosis Probable esterase LipL 0.0248 0.1515 0.1462
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0084 0.041
Trypanosoma brucei hypothetical protein, conserved 0.0248 0.1515 1
Schistosoma mansoni ran 0.0021 0.0071 0.0167
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0062 0.026
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0276 0.0647
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.184 0.6385
Brugia malayi hypothetical protein 0.0011 0.0009 0.0026
Schistosoma mansoni hypothetical protein 0.0337 0.2078 0.4871
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.0328
Schistosoma mansoni zinc finger protein 0.001 0.0002 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0048 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0421 0.9313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0327 0.0766
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0327 0.0766
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0029 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Loa Loa (eye worm) hypothetical protein 0.0061 0.0327 0.113
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0168 0.0489
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0327 0.0766
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0011 0.0034
Brugia malayi steroid hormone receptor 0.002 0.007 0.0239
Schistosoma mansoni memapsin-2 (A01 family) 0.0535 0.3334 0.7815
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0421 0.2426
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0946 0.2217
Schistosoma mansoni DNA polymerase eta 0.0019 0.0062 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.007 0.0239
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0029 0.0069
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0455 0.283 0.7001
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0065 0.0351 0.0673
Entamoeba histolytica hypothetical protein 0.0108 0.0624 0.7523
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0029 0.0069
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0796
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0048 0.016
Onchocerca volvulus 0.0035 0.0161 0.0537
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.007 0.0231
Loa Loa (eye worm) hypothetical protein 0.008 0.0447 0.1548
Trichomonas vaginalis set domain proteins, putative 0.0479 0.298 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.002 0.007 0.0231
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.021
Schistosoma mansoni inositol monophosphatase 0.0036 0.0168 0.0393
Brugia malayi beta-lactamase family protein 0.0248 0.1515 0.5255
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0029 0.0021
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0029 0.0097
Echinococcus granulosus smad 0.0017 0.0048 0.0112
Onchocerca volvulus 0.0029 0.0124 0.0413
Entamoeba histolytica Ran family GTPase 0.0021 0.0071 0.06
Loa Loa (eye worm) hypothetical protein 0.0031 0.014 0.0481
Echinococcus granulosus expressed protein 0.0014 0.0029 0.0069
Loa Loa (eye worm) hypothetical protein 0.0068 0.0372 0.1286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0009 0.0021
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0161 0.0625
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0029 0.0069
Plasmodium falciparum plasmepsin V 0.0035 0.0161 0.24
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.016
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0642 0.4016 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.007 0.0239
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.008 0.0447 0.1048
Schistosoma mansoni cpg binding protein 0.0031 0.0135 0.0316
Schistosoma mansoni hypothetical protein 0.0337 0.2078 0.4871
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0029 0.0069
Echinococcus multilocularis muscleblind protein 1 0.0452 0.281 0.6585
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0029 0.0069
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0455 0.283 0.2785
Trichomonas vaginalis esterase, putative 0.0248 0.1515 0.5044
Schistosoma mansoni cpg binding protein 0.0029 0.0124 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0163 0.0562
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.007 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.2017 0.4727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.007 0.0239
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0048 0.0112
Echinococcus multilocularis smad 0.0017 0.0048 0.0112
Echinococcus multilocularis cpg binding protein 0.0031 0.0135 0.0316
Schistosoma mansoni cathepsin D (A01 family) 0.0195 0.1177 0.2758
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0065 0.0351 0.0731
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0327 0.0766
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.007 0.0239
Toxoplasma gondii ABC1 family protein 0.0248 0.1515 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0029 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0248 0.1515 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0299 0.1579
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.2017 0.4727
Plasmodium vivax aspartyl proteinase, putative 0.008 0.0447 0.2605
Mycobacterium tuberculosis Probable lipase LipD 0.0248 0.1515 0.1462
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0048 0.016
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0011 0.0031
Onchocerca volvulus 0.0053 0.0276 0.0922
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.007 0.0165
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0029 0.0021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.007 0.0165
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0009 0.0021
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0161 0.0555
Plasmodium falciparum plasmepsin VII 0.0035 0.0161 0.24
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.007 0.0165
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.0447 0.1048
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.0328
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.007 0.0165
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1518 0.5266
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0163 0.0939
Mycobacterium leprae Probable lipase LipE 0.0248 0.1515 0.3635
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0062 0.0145
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0571 0.1979
Brugia malayi Smad1 0.0017 0.0048 0.016
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0168 0.0969
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0276 0.0647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0327 0.2017 0.4727
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0455 0.283 0.6982
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0299 0.0933
Schistosoma mansoni hypothetical protein 0.0322 0.1982 0.4646
Onchocerca volvulus 0.0248 0.1515 0.508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.014 0.0328
Schistosoma mansoni ran 0.0021 0.0071 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0421 0.2426
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0009 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0624 0.1462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0555
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0065 0.0351 0.0731
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0029 0.0069
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0084 0.0207
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0323 0.0756
Brugia malayi RNA, U transporter 1 0.008 0.0446 0.1544
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.007 0.0165
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0276 0.0647
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0087 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0248 0.1515 0.5044
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0087 0.0063
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0139 0.0821 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0405
Trypanosoma brucei unspecified product 0.0013 0.0024 0.0006
Entamoeba histolytica hypothetical protein 0.0108 0.0624 0.7523
Entamoeba histolytica hypothetical protein 0.0108 0.0624 0.7523
Echinococcus granulosus importin subunit beta 1 0.0028 0.0118 0.0277
Schistosoma mansoni hypothetical protein 0.0414 0.2564 0.601
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0029 0.0097
Plasmodium vivax aspartyl protease, putative 0.0035 0.0161 0.0625
Plasmodium falciparum plasmepsin IV 0.008 0.0447 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0163 0.0474
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0071 0.0321
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0009 0.0021
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0065 0.0351 0.0673
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0207
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0309 0.0723
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0026
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0065 0.0351 0.0291
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0248 0.1515 0.355
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0029 0.0069
Plasmodium falciparum ornithine aminotransferase 0.0065 0.0351 0.7441
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0276 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.007 0.0239
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0065 0.0351 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0276 0.0922
Trypanosoma brucei glucosidase, putative 0.0035 0.0163 0.0939
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0299 0.0933
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0026
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0029 0.0097
Brugia malayi hypothetical protein 0.0035 0.0161 0.0555
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0029 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0029 0.0069
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0004
Loa Loa (eye worm) Smad1 0.0017 0.0048 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0571 0.1979
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0474
Brugia malayi Latrophilin receptor protein 2 0.0031 0.014 0.0481
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.007 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.007 0.0239
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0029 0.0069
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0029 0.0097
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0168 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.007 0.0239
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.007 0.0231
Echinococcus granulosus Aminotransferase class III 0.0065 0.0351 0.0823
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.007 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.007 0.0165
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.1755
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.4267 1
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0029 0.0021
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0276 0.0647
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0026
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0029 0.0069
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0144 0.0083
Plasmodium vivax plasmepsin IV, putative 0.008 0.0447 0.2605
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0163 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.007 0.0239
Loa Loa (eye worm) MBCTL1 0.006 0.0323 0.1115
Brugia malayi MH2 domain containing protein 0.0249 0.1518 0.5266
Brugia malayi hypothetical protein 0.0011 0.0009 0.0026
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0029 0.0097
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0029 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.007 0.0239
Echinococcus granulosus beta LACTamase domain containing family member 0.0248 0.1515 0.355
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0087 0.0416
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0112
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0168 0.0969
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.007 0.0165
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.014 0.0328
Brugia malayi Importin beta-1 subunit 0.0028 0.0118 0.0405
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0327 0.2017 0.7
Schistosoma mansoni coup transcription factor 0.002 0.007 0.0165
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0065 0.0351 0.0731
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0299 0.1849
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.0351 0.0823
Echinococcus granulosus dna polymerase kappa 0.0019 0.0062 0.0145
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0946 0.328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0161 0.0555
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0372 0.1286
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0065 0.0351 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0029 0.0097
Plasmodium vivax plasmepsin V, putative 0.0035 0.0161 0.0625
Brugia malayi Steroid receptor seven-up type 2 0.002 0.007 0.0239
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.0636
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0323 0.0756
Brugia malayi nuclear receptor NHR-88 0.002 0.007 0.0239
Echinococcus granulosus dna polymerase eta 0.0019 0.0062 0.0145
Mycobacterium ulcerans L-lysine aminotransferase 0.0065 0.0351 0.0731
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.0328
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0062 0.0131
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0327 0.2017 0.7
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.026
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0299 0.0701
Trypanosoma brucei unspecified product 0.0013 0.0024 0.0006
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0065 0.0351 0.0673
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0071 0.0321
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0323 0.0756
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0065 0.0351 0.1214
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0004
Mycobacterium ulcerans acetylornithine aminotransferase 0.0065 0.0351 0.0731
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0048 0.0112
Brugia malayi nuclear receptor RXR 0.0011 0.0009 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.007 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Schistosoma mansoni alpha-glucosidase 0.0136 0.0806 0.1889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.007 0.0239
Plasmodium falciparum plasmepsin I 0.008 0.0447 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0139 0.0821 1
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Brugia malayi hypothetical protein 0.0035 0.0161 0.0555
Giardia lamblia Fructose-bisphosphate aldolase 0.0139 0.0821 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.007 0.0165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.007 0.0165
Mycobacterium tuberculosis Conserved protein 0.0248 0.1515 0.1462
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0163 0.0939
Brugia malayi Muscleblind-like protein 0.0452 0.281 0.9752
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0161 0.0555
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0029 0.0069
Onchocerca volvulus 0.0092 0.0522 0.1747
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0048 0.0112
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0323 0.1115
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0002 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.007 0.0165
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0087 0.0108
Echinococcus granulosus FTZ F1 alpha 0.002 0.007 0.0165
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0071 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.014 0.0481
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.007 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0299 0.0701
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0124 0.0427
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2612 0.9065
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0118 0.0636
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0029 0.0069
Schistosoma mansoni hypothetical protein 0.0068 0.0372 0.0871
Plasmodium vivax hypothetical protein, conserved 0.0248 0.1515 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0299 0.1849
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0118 0.0277
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.0351 0.0823
Brugia malayi CXXC zinc finger family protein 0.0029 0.0124 0.0427
Trypanosoma brucei protein kinase, putative 0.0057 0.0299 0.1849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0327 0.2017 0.4727
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0026
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0421 0.2669
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0065 0.0351 0.0291
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0023 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Mycobacterium tuberculosis Probable aminotransferase 0.0455 0.283 0.2785
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0299 0.1849
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0642 0.4016 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0163 0.0474
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0087 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0299 0.0933
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0029 0.0021
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0029 0.0097
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0163 0.0562
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0461 0.1081
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0248 0.1515 0.1462
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0624 0.1462
Schistosoma mansoni cpg binding protein 0.0031 0.0135 0.0316
Schistosoma mansoni hypothetical protein 0.0108 0.0624 0.1462
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0299 0.0701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Echinococcus granulosus dnaJ subfamily B 0.0414 0.2564 0.601
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.007 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.007 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0327 0.0766
Loa Loa (eye worm) steroid hormone receptor 0.002 0.007 0.0239
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0029 0.0069
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0029 0.0021
Echinococcus granulosus Smad4 0.0017 0.0048 0.0112
Leishmania major hypothetical protein, conserved 0.0248 0.1515 1
Onchocerca volvulus 0.0014 0.0029 0.0094
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0161 0.0625
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0065 0.0351 0.0291
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0299 0.1849
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Plasmodium vivax aspartyl protease, putative 0.0035 0.0161 0.0625
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0048 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0345 0.0809
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0062 0.0145
Brugia malayi ecdysteroid receptor 0.002 0.007 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0168 0.067
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0168 0.0268
Echinococcus granulosus cpg binding protein 0.0031 0.0135 0.0316
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.2564 0.601
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.007 0.0165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.014 0.0328
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1518 0.5266
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Mycobacterium ulcerans lipase LipD 0.0248 0.1515 0.3674
Leishmania major importin beta-1 subunit, putative 0.0023 0.0084 0.041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0248 0.1515 0.3674
Trypanosoma brucei unspecified product 0.0019 0.0062 0.026
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0299 0.3122
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0461 0.1597
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0029 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0168 0.0393
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0248 0.1515 0.1462
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Treponema pallidum fructose-bisphosphate aldolase 0.0139 0.0821 1
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0029 0.0097
Schistosoma mansoni thyroid hormone receptor 0.002 0.007 0.0165
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Trichomonas vaginalis penicillin-binding protein, putative 0.0248 0.1515 0.5044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.007 0.0165
Echinococcus granulosus microtubule associated protein 2 0.0682 0.4267 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0248 0.1515 0.1462
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0139 0.0821 0.2699
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.008 0.0447 0.1434
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0087 0.0426
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0168 0.0489
Plasmodium vivax SET domain protein, putative 0.0061 0.0327 0.1771
Onchocerca volvulus 0.0014 0.0029 0.0094
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0087 0.0063
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0299 0.1033
Brugia malayi mbt repeat family protein 0.0053 0.0276 0.0954
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0303 0.1608
Plasmodium falciparum plasmepsin III 0.0035 0.0161 0.24
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0248 0.1515 0.5255
Onchocerca volvulus 0.0248 0.1515 0.508
Echinococcus granulosus geminin 0.0337 0.2078 0.4871
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0062 0.026
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0421 0.9313
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.0328
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0112
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0276 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Echinococcus multilocularis GPCR, family 2 0.0031 0.014 0.0328
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0029 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.007 0.0239
Plasmodium falciparum plasmepsin X 0.0035 0.0161 0.24
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0239
Brugia malayi hypothetical protein 0.0108 0.0624 0.2161
Onchocerca volvulus 0.0082 0.0461 0.1544
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0161 0.0555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0026
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0366
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0071 0.0321
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0461 0.1081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.007 0.0165
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.007 0.0165
Plasmodium falciparum plasmepsin II 0.008 0.0447 1
Brugia malayi mbt repeat family protein 0.0053 0.0276 0.0954
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0163 0.0939
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0276 0.0647
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0004
Loa Loa (eye worm) beta-lactamase 0.0248 0.1515 0.5255
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0163 0.0383
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0474
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0009 0.0026
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.016
Plasmodium vivax ornithine aminotransferase, putative 0.0065 0.0351 0.1939
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0327 0.0766
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0029 0.0097
Mycobacterium tuberculosis Probable hydrolase 0.0248 0.1515 0.1462
Mycobacterium tuberculosis Conserved protein 0.0248 0.1515 0.1462
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1264 0.2962
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0624 0.1462
Onchocerca volvulus 0.0248 0.1515 0.508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.007 0.0165
Plasmodium falciparum plasmepsin IX 0.0035 0.0161 0.24
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0029 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0161 0.0378
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0168 0.0969
Schistosoma mansoni smad 0.0017 0.0048 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0299 0.1849
Schistosoma mansoni nuclear hormone receptor 0.002 0.007 0.0165
Plasmodium vivax aspartyl protease, putative 0.0035 0.0161 0.0625
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0571 0.1979
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Echinococcus granulosus snurportin 1 0.0299 0.184 0.4312
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.007 0.0239
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0029 0.0069
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0029 0.0069
Brugia malayi G-protein alpha subunit 0.0014 0.0029 0.0097
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.007 0.0239
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0087 0.0108
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0112
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.007 0.0165
Loa Loa (eye worm) hypothetical protein 0.0248 0.1515 0.5255
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0299 0.1849
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.007 0.0165
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0065 0.0351 0.0291
Echinococcus multilocularis muscleblind protein 0.0452 0.281 0.6585
Brugia malayi beta-lactamase 0.0248 0.1515 0.5255
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0168 0.0969
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0163 0.0474
Loa Loa (eye worm) hypothetical protein 0.0099 0.0571 0.1979
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0946 0.328
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.007 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.007 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.2017 0.4727
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0168 0.0489
Brugia malayi hypothetical protein 0.0014 0.0029 0.0097
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0163 0.0383
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0062 0.0485
Toxoplasma gondii aspartyl protease ASP1 0.008 0.0447 0.2605
Loa Loa (eye worm) hypothetical protein 0.0076 0.0421 0.1458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.007 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.007 0.0239
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0163 0.0474
Loa Loa (eye worm) hypothetical protein 0.0053 0.0276 0.0954
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0474
Brugia malayi follicle stimulating hormone receptor 0.0463 0.2881 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0065 0.0351 0.0823
Schistosoma mansoni Smad4 0.0017 0.0048 0.0112
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.008 0.0447 0.2605
Entamoeba histolytica hypothetical protein 0.0108 0.0624 0.7523
Schistosoma mansoni alpha-glucosidase 0.0136 0.0806 0.1889
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0421 0.2669
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0071 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.007 0.0239
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0029 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0248 0.1515 0.5044
Trichomonas vaginalis ran, putative 0.0021 0.0071 0.0162
Brugia malayi nuclear hormone receptor 0.002 0.007 0.0239
Echinococcus multilocularis expressed protein 0.0014 0.0029 0.0069
Brugia malayi Pepsin A precursor 0.0035 0.0161 0.0555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0327 0.2017 0.4727
Brugia malayi hypothetical protein 0.0049 0.0251 0.0866
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.007 0.0165
Toxoplasma gondii aspartyl protease 0.0035 0.0161 0.0625
Echinococcus multilocularis beta LACTamase domain containing family member 0.0248 0.1515 0.355
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0248 0.1515 0.355
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0163 0.0474
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1264 0.2962
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0299 0.1849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.007 0.0239
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.008 0.0447 0.1048
Leishmania major hypothetical protein, conserved 0.0076 0.0421 0.2669
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.4267 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0946 0.2217
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0299 0.0701
Trichomonas vaginalis D-aminoacylase, putative 0.0248 0.1515 0.5044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.0207
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0642 0.4016 0.3978
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0029 0.0069
Echinococcus multilocularis snurportin 1 0.0299 0.184 0.4312
Loa Loa (eye worm) hypothetical protein 0.0082 0.0461 0.1597
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0062 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0248 0.1515 0.5044
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0071 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0026
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0004
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0087 0.0426
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0029 0.0069
Schistosoma mansoni importin beta-1 0.0028 0.0118 0.0277
Loa Loa (eye worm) aspartic protease BmAsp-2 0.008 0.0447 0.1548
Onchocerca volvulus 0.002 0.007 0.0231
Echinococcus multilocularis Aminotransferase class III 0.0065 0.0351 0.0823
Plasmodium falciparum plasmepsin VI 0.008 0.0447 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0097
Onchocerca volvulus 0.0035 0.0161 0.0537
Brugia malayi Pre-SET motif family protein 0.0061 0.0327 0.113
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0002 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.007 0.0165
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0029 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.026
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0421 0.2669
Loa Loa (eye worm) inositol-1 0.0036 0.0168 0.0578
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0168 0.1812
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.021
Schistosoma mansoni hypothetical protein 0.0299 0.184 0.4312
Brugia malayi Inositol-1 0.0036 0.0168 0.0578
Schistosoma mansoni cathepsin D (A01 family) 0.0195 0.1177 0.2758

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 1000 nM Cytotoxicity against HEK293 cells expressing swedish-mutant APP FAD isoform ChEMBL. 19811916
IC50 (binding) = 2327 nM Inhibition of cathepsin D assessed as reduction in polarization after 110 mins by oregon green based fluorescence polarization assay ChEMBL. 19811916
IC50 (binding) > 10000 nM Inhibition of recombinant BACE1 expressed in Escherichia coli after 3 hrs by oregon green based fluorescence polarization assay ChEMBL. 19811916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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