TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 406.412 | Formula: C14H15N4NaO5S2
H donors: 2 H acceptors: 5 LogP: 1.37 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(c1ccc(cc1)/N=N/c1cccc(c1)S(=O)(=O)N)CS(=O)(=O)[O-].[Na+]
InChi: 1S/C14H16N4O5S2.Na/c1-18(10-24(19,20)21)13-7-5-11(6-8-13)16-17-12-3-2-4-14(9-12)25(15,22)23;/h2-9H,10H2,1H3,(H2,15,22,23)(H,19,20,21);/q;+1/p-1/b17-16+;
InChiKey: LMFUVMZOQGPKKM-CMBBICFISA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)		References
Homo sapiens	carbonic anhydrase IX	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase XII	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Mycobacterium ulcerans	integral membrane transporter	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Plasmodium yoelii	sulfate permease family protein	Get druggable targets OG5_129533	All targets in OG5_129533
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Mycobacterium leprae	Probable transmembrane transport protein	Get druggable targets OG5_129533	All targets in OG5_129533
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Plasmodium vivax	sulfate transporter, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Chlamydia trachomatis	sulfate transporter	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_129533	All targets in OG5_129533
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Neospora caninum	hypothetical protein	Get druggable targets OG5_129533	All targets in OG5_129533
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma congolense	hypothetical protein, conserved	Get druggable targets OG5_129533	All targets in OG5_129533
Babesia bovis	sulfate transporter, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Plasmodium berghei	inorganic anion antiporter, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma congolense	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Mycobacterium tuberculosis	Probable conserved transmembrane protein	Get druggable targets OG5_129533	All targets in OG5_129533
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	Get druggable targets OG5_129533	All targets in OG5_129533
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	Get druggable targets OG5_129533	All targets in OG5_129533
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	Get druggable targets OG5_129533	All targets in OG5_129533
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Plasmodium knowlesi	sulfate transporter, putative	Get druggable targets OG5_129533	All targets in OG5_129533
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	Get druggable targets OG5_129533	All targets in OG5_129533
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Theileria parva	sulfate transporter, putative	Get druggable targets OG5_129533	All targets in OG5_129533

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	carbonic anhydrase XII	354 aa	295 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.048	0.3787	0.5112
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.047	0.0632
Plasmodium vivax	sulfate transporter, putative	0.0039	0.016	0.1169
Trichomonas vaginalis	set domain proteins, putative	0.0933	0.7518	0.7518
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0665	0.0853
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0034	0.0114	0.0138
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0034	0.0114	0.0138
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0567	0.4507	0.6545
Echinococcus multilocularis	geminin	0.0854	0.6866	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1642	0.2203
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0126	0.0891
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.051	0.051
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0371	0.213
Schistosoma mansoni	hypothetical protein	0.004	0.0165	0.0211
Schistosoma mansoni	hypothetical protein	0.004	0.0165	0.0211
Brugia malayi	CHE-14 protein	0.0041	0.0177	0.0189
Trichomonas vaginalis	glucosylceramidase, putative	0.0371	0.2895	0.2895
Trypanosoma brucei	ISWI complex protein	0.0079	0.0484	0.2853
Echinococcus multilocularis	chromobox protein 2	0.0034	0.0114	0.0111
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.1806
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.1079	0.1079
Echinococcus granulosus	chromobox protein 1	0.0206	0.1533	0.2189
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0151	0.1079	0.1524
Echinococcus granulosus	geminin	0.0854	0.6866	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0185	0.1358	0.1932
Schistosoma mansoni	pyruvate kinase	0.0033	0.0106	0.0126
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.005	0.0246	0.1329
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0039	0.016	0.0778
Onchocerca volvulus		0.0091	0.0582	0.0643
Mycobacterium ulcerans	esterase/lipase LipP	0.0151	0.1079	0.0984
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0223	0.1395
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0331	0.0448
Echinococcus granulosus	Chromobox protein 3	0.0034	0.0114	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0039	0.016	0.1169
Echinococcus granulosus	lamin dm0	0.0105	0.0703	0.0974
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0223	0.0119
Onchocerca volvulus		0.0917	0.7391	0.9829
Entamoeba histolytica	hypothetical protein	0.0034	0.0114	0.1806
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.0262	0.1991	0.2817
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0106	0.0092
Trichomonas vaginalis	glutathione reductase, putative	0.005	0.0246	0.0246
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0371	0.0487
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0371	0.0505
Onchocerca volvulus		0.0151	0.1082	0.1317
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0665	0.0918
Echinococcus granulosus	pyruvate kinase	0.0033	0.0106	0.0099
Echinococcus multilocularis	Chromobox protein 3	0.0034	0.0114	0.0111
Schistosoma mansoni	hypothetical protein	0.0094	0.0614	0.0851
Loa Loa (eye worm)	PHD-finger family protein	0.0106	0.071	0.0939
Onchocerca volvulus		0.0034	0.0114	0.0011
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.005	0.0246	0.0142
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0214	0.1601	0.2126
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.005	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0072	0.0074
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0537	0.4259	0.5753
Entamoeba histolytica	hypothetical protein	0.0077	0.047	0.7443
Mycobacterium ulcerans	integral membrane transporter	0.0039	0.016	0.0055
Entamoeba histolytica	hypothetical protein	0.0034	0.0114	0.1806
Trypanosoma brucei	trypanothione reductase	0.0144	0.1018	0.6272
Trichomonas vaginalis	penicillin-binding protein, putative	0.0151	0.1079	0.1079
Plasmodium vivax	thioredoxin reductase, putative	0.0144	0.1018	0.9419
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1461	0.1957
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0144	0.1018	0.0971
Loa Loa (eye worm)	glutathione reductase	0.0144	0.1018	0.1358
Echinococcus multilocularis	lamin dm0	0.0105	0.0703	0.0974
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0223	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0917	0.7391	1
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0106	0.0099
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0049	0.0016
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.0114
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0106	0.0649
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0037	0.0137	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0917	0.7391	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0151	0.1079	0.6739
Brugia malayi	Heterochromatin protein 1	0.0206	0.1533	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0147
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0072	0.0327
Schistosoma mansoni	microtubule-associated protein tau	0.0711	0.5692	0.8098
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.005	0.0246	0.1536
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0106	0.066
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0331	0.207
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0371	0.2317
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0126	0.002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0327	0.2533	0.2581
Entamoeba histolytica	hypothetical protein	0.0077	0.047	0.7443
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0665	0.0918
Brugia malayi	Protein cec-1.	0.0034	0.0114	0.0103
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Brugia malayi	hypothetical protein	0.0243	0.184	0.245
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0151	0.1079	0.144
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0327	0.2533	0.8897
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0072	0.0327
Echinococcus granulosus	snurportin 1	0.0262	0.1991	0.2861
Brugia malayi	hypothetical protein	0.0917	0.7391	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0298	0.2293	0.3067
Trichomonas vaginalis	glucosylceramidase, putative	0.0371	0.2895	0.2895
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0072	0.0451
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0665	0.0918
Echinococcus multilocularis	microtubule associated protein 2	0.0711	0.5692	0.8281
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0151	0.1079	0.1415
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Brugia malayi	Bromodomain containing protein	0.0197	0.1458	0.1931
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0106	0.066
Plasmodium falciparum	pyruvate kinase	0.0033	0.0106	0.0689
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0787	0.0787
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.005	0.0246	0.0142
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0114	0.0729
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0088	0.0558	0.0772
Trichomonas vaginalis	chromobox protein, putative	0.0124	0.086	0.086
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0665	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0243	0.184	0.2471
Toxoplasma gondii	thioredoxin reductase	0.0144	0.1018	0.9419
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0037	0.0137	0.0135
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0034	0.0114	0.0774
Echinococcus granulosus	expressed conserved protein	0.0091	0.0583	0.0798
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0118	0.0804	0.1122
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0039	0.016	0.0998
Trypanosoma cruzi	ISWI complex protein	0.0079	0.0484	0.3023
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0327	0.2533	0.2581
Mycobacterium tuberculosis	Probable hydrolase	0.0151	0.1079	0.1035
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0143	0.1014	0.1422
Brugia malayi	Pre-SET motif family protein	0.082	0.6585	0.8905
Loa Loa (eye worm)	thioredoxin reductase	0.0144	0.1018	0.1358
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0223	0.0432
Schistosoma mansoni	hypothetical protein	0.004	0.0165	0.0211
Brugia malayi	SET domain containing protein	0.0038	0.015	0.0152
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0034	0.0114	0.0774
Echinococcus multilocularis	snurportin 1	0.0262	0.1991	0.2861
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0567	0.4507	0.6545
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0665	0.0853
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Schistosoma mansoni	zinc finger protein	0.0079	0.0484	0.0666
Echinococcus granulosus	lamin	0.0105	0.0703	0.0974
Leishmania major	hypothetical protein, conserved	0.0079	0.0484	0.3023
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0163	0.1177	0.1549
Schistosoma mansoni	lozenge	0.0115	0.0784	0.1094
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0307	0.2364	0.3406
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0146	0.0158
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0143	0.1014	0.1429
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0205	0.1526	0.218
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0039	0.016	0.0055
Trichomonas vaginalis	Heterochromatin protein, putative	0.0034	0.0114	0.0114
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0094	0.0614	0.0843
Onchocerca volvulus		0.0034	0.0114	0.0011
Leishmania major	carbonic anhydrase-like protein	0.0214	0.1601	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0106	0.0432
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0072	0.0451
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0223	0.0252
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0331	0.0228
Schistosoma mansoni	lipoxygenase	0.008	0.0494	0.0681
Echinococcus multilocularis	polycomb protein SCMH1	0.0143	0.1014	0.1429
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0331	0.0228
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Schistosoma mansoni	hypothetical protein	0.0854	0.6866	0.9773
Brugia malayi	glutathione reductase	0.0144	0.1018	0.1333
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Leishmania major	hypothetical protein, conserved	0.0029	0.0072	0.0451
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0214	0.1601	0.2148
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0665	0.0918
Schistosoma mansoni	patched 1	0.0041	0.0177	0.0228
Schistosoma mansoni	chromobox protein	0.0034	0.0114	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0177	0.0217
Toxoplasma gondii	hypothetical protein	0.0101	0.0665	0.6025
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.006	0.0326	0.0809
Chlamydia trachomatis	sulfate transporter	0.0039	0.016	0.386
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0143	0.1014	0.1225
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0044	0.0195	0.023
Mycobacterium leprae	Probable lipase LipE	0.0151	0.1079	0.3568
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.047	0.0632
Brugia malayi	hypothetical protein	0.0465	0.3661	0.4927
Brugia malayi	hypothetical protein	0.0034	0.0114	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0106	0.0432
Echinococcus granulosus	Chromo domain	0.0034	0.0114	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0223	0.0279
Echinococcus multilocularis	protein patched	0.0041	0.0177	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0298	0.2293	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0051	0.0255	0.0317
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0331	0.2817
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0177	0.0204
Brugia malayi	intermediate filament protein	0.0105	0.0703	0.0905
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0371	0.0487
Brugia malayi	Bromodomain containing protein	0.0386	0.3011	0.4044
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0223	0.0279
Mycobacterium tuberculosis	Conserved protein	0.0151	0.1079	0.1035
Trichomonas vaginalis	chromobox protein, putative	0.0124	0.086	0.086
Schistosoma mansoni	chromobox protein	0.0206	0.1533	0.2163
Mycobacterium leprae	conserved hypothetical protein	0.0151	0.1079	0.3568
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0126	0.0839
Plasmodium vivax	glutathione reductase, putative	0.0144	0.1018	0.9419
Echinococcus multilocularis	GPCR, family 2	0.0094	0.0614	0.0843
Brugia malayi	beta-lactamase family protein	0.0151	0.1079	0.1415
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0177	0.0204
Treponema pallidum	NADH oxidase	0.005	0.0246	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0688	0.0909
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0151	0.1079	0.1035
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0223	0.0252
Brugia malayi	CHD4 protein	0.0044	0.0195	0.0213
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0106	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.1234	1	1
Schistosoma mansoni	hypothetical protein	0.004	0.0165	0.0211
Plasmodium falciparum	carbonic anhydrase	0.0101	0.0665	0.6397
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.005	0.0246	0.1996
Trypanosoma cruzi	ISWI complex protein	0.0079	0.0484	0.3023
Loa Loa (eye worm)	beta-lactamase	0.0151	0.1079	0.144
Schistosoma mansoni	importin beta-1	0.0025	0.0038	0.003
Schistosoma mansoni	lipoxygenase	0.0114	0.0778	0.1085
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Echinococcus granulosus	polycomb protein SCMH1	0.0143	0.1014	0.1429
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.005	0.0246	0.0149
Schistosoma mansoni	hypothetical protein	0.0101	0.0665	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0147
Brugia malayi	Valyl-tRNA synthetase	0.0034	0.0114	0.0103
Schistosoma mansoni	hypothetical protein	0.0106	0.071	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0631	0.0833
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0972	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0024	0.0009
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0106	0.012
Echinococcus granulosus	pyruvate kinase	0.0033	0.0106	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1526	0.2046
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0665	0.0925
Schistosoma mansoni	chromobox protein	0.0034	0.0114	0.0138
Onchocerca volvulus		0.0173	0.1261	0.1559
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0371	0.2317
Echinococcus granulosus	GPCR family 2	0.0094	0.0614	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.005	0.0246	0.5
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0583	0.0798
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0151	0.1079	0.1035
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Loa Loa (eye worm)	mbt repeat family protein	0.0143	0.1014	0.1351
Brugia malayi	beta-lactamase	0.0151	0.1079	0.1415
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0038	0.0028
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.005	0.0246	0.2119
Loa Loa (eye worm)	transcription factor SMAD2	0.0259	0.1968	0.2646
Leishmania major	pyruvate kinase	0.0033	0.0106	0.066
Onchocerca volvulus		0.0151	0.1079	0.1313
Echinococcus multilocularis	Protein lozenge	0.0115	0.0784	0.1092
Mycobacterium tuberculosis	Conserved protein	0.0151	0.1079	0.1035
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.005	0.0246	0.1329
Brugia malayi	RNA, U transporter 1	0.007	0.041	0.0506
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.005	0.0246	0.1536
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0034	0.0114	0.0729
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0151	0.1079	0.1035
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0151	0.1079	0.1515
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0072	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.1381	0.1945
Schistosoma mansoni	hypothetical protein	0.0094	0.0614	0.0851
Leishmania major	carbonic anhydrase family protein, putative	0.006	0.0326	0.2039
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0034	0.0114	0.0111
Onchocerca volvulus		0.0143	0.1014	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Loa Loa (eye worm)	intermediate filament protein	0.0105	0.0703	0.093
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0246	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0254	0.0321
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.005	0.0246	0.0142
Mycobacterium tuberculosis	Probable dehydrogenase	0.0327	0.2533	0.2581
Schistosoma mansoni	hypothetical protein	0.0204	0.1516	0.2138
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.1381	0.1966
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0185	0.1358	0.1932
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0331	0.024
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.011	0.0004
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0331	0.0448
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0106	0.012
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0665	0.0879
Onchocerca volvulus		0.0095	0.0616	0.0689
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0223	0.3539
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0088	0.0558	0.0762
Mycobacterium ulcerans	lipase LipD	0.0151	0.1079	0.0984
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0344	0.2672	0.2729
Schistosoma mansoni	survival motor neuron protein	0.0095	0.0616	0.0855
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0371	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0665	0.0879
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0034	0.0114	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1261	0.1687
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.051	0.051
Echinococcus multilocularis	survival motor neuron protein 1	0.0465	0.3661	0.5306
Echinococcus multilocularis	musashi	0.0105	0.0703	0.0974
Loa Loa (eye worm)	bromodomain containing protein	0.0091	0.0584	0.0769
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.082	0.6585	0.8908
Brugia malayi	MH2 domain containing protein	0.0259	0.1968	0.2625
Mycobacterium tuberculosis	Probable oxidoreductase	0.0364	0.2834	0.2901
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0116	0.0791	0.1102
Onchocerca volvulus	Glucosylceramidase homolog	0.0352	0.2738	0.3552
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Trypanosoma brucei	hypothetical protein, conserved	0.0151	0.1079	0.6659
Loa Loa (eye worm)	heterochromatin protein 1	0.0206	0.1533	0.2056
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0223	0.1395
Trypanosoma cruzi	trypanothione reductase, putative	0.0144	0.1018	0.6361
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0327	0.2533	0.2581
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0116	0.0791	0.1104
Onchocerca volvulus	Huntingtin homolog	0.0243	0.184	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0034	0.0114	0.0729
Brugia malayi	follicle stimulating hormone receptor	0.048	0.3787	0.5098
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0223	0.0252
Onchocerca volvulus		0.0105	0.0703	0.0806
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0223	0.0125
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Schistosoma mansoni	sex comb on midleg homolog	0.0143	0.1014	0.1422
Loa Loa (eye worm)	helicase	0.0034	0.0114	0.0131
Schistosoma mansoni	carbonic anhydrase	0.006	0.0326	0.0441
Echinococcus granulosus	intermediate filament protein	0.0105	0.0703	0.0974
Schistosoma mansoni	sex comb on midleg homolog	0.0143	0.1014	0.1422
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0146	0.0158
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0116	0.0787	0.092
Onchocerca volvulus		0.0247	0.1867	0.2377
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0582	0.0766
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0327	0.2533	0.2581
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0223	0.0119
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0114	0.0778	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0147
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.0114
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0371	0.5876
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.005	0.0246	0.2119
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0094	0.0614	0.0809
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0631	0.0807
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0223	0.1395
Schistosoma mansoni	hypothetical protein	0.0077	0.047	0.0646
Schistosoma mansoni	pyruvate kinase	0.0033	0.0106	0.0126
Schistosoma mansoni	intermediate filament proteins	0.0105	0.0703	0.0979
Echinococcus granulosus	chromobox protein 2	0.0034	0.0114	0.0111
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0088	0.0558	0.0762
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0205	0.1526	0.2153
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1601	0.226
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0239	0.03
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0298	0.2293	0.3087
Loa Loa (eye worm)	MH2 domain-containing protein	0.0259	0.1968	0.2646
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1601	0.226
Echinococcus multilocularis	carbonic anhydrase II	0.0214	0.1601	0.2289
Brugia malayi	hypothetical protein	0.0029	0.0072	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0223	0.0279
Trichomonas vaginalis	conserved hypothetical protein	0.1234	1	1
Mycobacterium ulcerans	beta-lactamase	0.0151	0.1079	0.0984
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0205	0.1526	0.2153
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0665	0.0853
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0056	0.0301	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0147
Echinococcus multilocularis	zinc finger protein	0.0101	0.0665	0.0918
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0144	0.1023	0.1443
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.1806
Brugia malayi	latrophilin 2 splice variant baaae	0.0204	0.1516	0.201
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0039	0.016	0.0998
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0223	0.3539
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0537	0.4259	0.5741
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0223	0.0119
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0665	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0703	0.093
Entamoeba histolytica	hypothetical protein	0.0077	0.047	0.7443
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.047	0.0646
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Schistosoma mansoni	bromodomain containing protein	0.0325	0.2515	0.3565
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0262	0.1991	0.2677
Entamoeba histolytica	carbonic anhydrase, putative	0.006	0.0326	0.5171
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0163	0.1177	0.1668
Brugia malayi	Associated with TFs and helicases family protein	0.0034	0.0114	0.0103
Echinococcus granulosus	fetal alzheimer antigen falz	0.0116	0.0791	0.1102
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0177	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0787	0.0787
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0094	0.0614	0.0783
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0223	0.0119
Leishmania major	trypanothione reductase	0.0144	0.1018	0.6361
Plasmodium falciparum	glutathione reductase	0.005	0.0246	0.2119
Entamoeba histolytica	hypothetical protein	0.0034	0.0114	0.1806
Schistosoma mansoni	hypothetical protein	0.0034	0.0114	0.0138
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.011	0.0004
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1601	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.0114
Schistosoma mansoni	zinc finger protein	0.0101	0.0665	0.0924
Plasmodium vivax	SET domain protein, putative	0.0118	0.0804	0.7362
Trypanosoma cruzi	hypothetical protein, conserved	0.0151	0.1079	0.6739
Plasmodium falciparum	heterochromatin protein 1	0.0034	0.0114	0.0774
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0126	0.0021
Schistosoma mansoni	hypothetical protein	0.0854	0.6866	0.9773
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0665	0.0925
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.005	0.0246	0.0304
Brugia malayi	mbt repeat family protein	0.0143	0.1014	0.1327
Onchocerca volvulus		0.0933	0.7518	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0787	0.1044
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0665	0.0879
Loa Loa (eye worm)	MBCTL1	0.0163	0.1177	0.1572
Loa Loa (eye worm)	carbonic anhydrase 3	0.0214	0.1601	0.2148
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0034	0.0114	0.0138
Giardia lamblia	NADH oxidase lateral transfer candidate	0.005	0.0246	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.1381	0.1945
Entamoeba histolytica	hypothetical protein	0.0077	0.047	0.7443
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0188	0.1381	0.1849
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.005	0.0246	0.1329
Brugia malayi	chromobox protein homolog 3	0.0116	0.0787	0.1019
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0371	0.2317
Trichomonas vaginalis	glucosylceramidase, putative	0.0537	0.4259	0.4259
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.0114
Mycobacterium ulcerans	carbonic anhydrase	0.006	0.0326	0.0223
Toxoplasma gondii	ABC1 family protein	0.0151	0.1079	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0371	0.048
Mycobacterium tuberculosis	Probable lipase LipE	0.0151	0.1079	0.1035
Brugia malayi	Pre-SET motif family protein	0.0118	0.0804	0.1042
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0118	0.0804	0.7362
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0298	0.2293	0.3067
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0331	0.0429
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0024	0.0383
Echinococcus granulosus	survival motor neuron protein 1	0.0465	0.3661	0.5306
Echinococcus granulosus	thioredoxin glutathione reductase	0.0144	0.1023	0.1443
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0072	0.0347
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0614	0.0809
Echinococcus multilocularis	chromobox protein 1	0.0206	0.1533	0.2189
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Trypanosoma brucei	carbonic anhydrase-like protein	0.0214	0.1601	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0095	0.0616	0.0786
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1177	0.1572
Echinococcus granulosus	microtubule associated protein 2	0.0711	0.5692	0.8281
Schistosoma mansoni	hypothetical protein	0.0094	0.0614	0.0851
Brugia malayi	mbt repeat family protein	0.0143	0.1014	0.1327
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0223	0.3539
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0223	0.0119
Brugia malayi	cytoplasmic intermediate filament protein	0.0056	0.0301	0.0357
Brugia malayi	hypothetical protein	0.0077	0.047	0.0587
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.005	0.0246	0.1996
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0106	0.012
Brugia malayi	PHD-finger family protein	0.0128	0.0891	0.116
Brugia malayi	beta-lactamase family protein	0.0151	0.1079	0.1415
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0631	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0143	0.1014	0.1429
Trichomonas vaginalis	mercuric reductase, putative	0.005	0.0246	0.0246
Mycobacterium tuberculosis	Probable lipase LipD	0.0151	0.1079	0.1035
Onchocerca volvulus		0.0151	0.1079	0.1313
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.005	0.0246	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1516	0.2032
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0034	0.0114	0.0111
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.1381	0.1966
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0044	0.0195	0.023
Trichomonas vaginalis	chromobox protein, putative	0.0206	0.1533	0.1533
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1079	0.144
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.005	0.0246	0.1996
Echinococcus granulosus	histone lysine methyltransferase setb	0.0205	0.1526	0.218
Leishmania major	hypothetical protein, conserved	0.0151	0.1079	0.6739
Mycobacterium ulcerans	hypothetical protein	0.0151	0.1079	0.0984
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0094	0.0614	0.0843
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.011	0.0004
Brugia malayi	Thioredoxin reductase	0.0144	0.1018	0.1333
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0034	0.0114	0.0114
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0223	0.0119
Echinococcus granulosus	beta LACTamase domain containing family member	0.0151	0.1079	0.1524
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0114	0.0729
Onchocerca volvulus		0.0105	0.0703	0.0806
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0039	0.016	0.0055
Brugia malayi	Intermediate filament tail domain containing protein	0.0105	0.0703	0.0905
Echinococcus granulosus	chromobox protein 1	0.0206	0.1533	0.2189
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0364	0.2834	0.2901
Schistosoma mansoni	lamin	0.0105	0.0703	0.0979
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0124	0.086	0.1017
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0177	0.0177
Plasmodium vivax	hypothetical protein, conserved	0.0151	0.1079	1
Echinococcus multilocularis	chromobox protein 1	0.0206	0.1533	0.2189
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0118	0.0804	0.1123
Trichomonas vaginalis	glucosylceramidase, putative	0.0352	0.2738	0.2738
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0151	0.1079	0.1515
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.1175	0.951	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0964	0.7775	0.8155
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0255	0.0322
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.011	0.0004
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0364	0.2834	0.2901
Echinococcus multilocularis	Chromo domain	0.0034	0.0114	0.0111
Echinococcus granulosus	histone acetyltransferase MYST2	0.0163	0.1177	0.1668
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0072	0.0347
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0285	0.2182	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.005	0.0246	0.1536
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0331	0.0228
Leishmania major	pyruvate kinase	0.0033	0.0106	0.066
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0051	0.0255	0.0317
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.005	0.0246	0.0283
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0151	0.1082	0.1519
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Onchocerca volvulus	Putative sulfate transporter	0.0247	0.1867	0.2377
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0223	0.0125
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.0114
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Brugia malayi	Latrophilin receptor protein 2	0.0094	0.0614	0.0783
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0044	0.0195	0.0253
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0177	0.0217
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0631	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0465	0.3661	0.4942
Echinococcus multilocularis	lamin	0.0105	0.0703	0.0974
Mycobacterium leprae	Probable transmembrane transport protein	0.0285	0.2182	0.7612
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0094	0.0614	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0243	0.184	0.2471
Trichomonas vaginalis	chromobox protein, putative	0.0206	0.1533	0.1533
Trichomonas vaginalis	esterase, putative	0.0151	0.1079	0.1079
Plasmodium falciparum	thioredoxin reductase	0.005	0.0246	0.2119
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0226	0.0275
Loa Loa (eye worm)	runx1	0.0115	0.0784	0.104
Schistosoma mansoni	hypothetical protein	0.0094	0.0614	0.0851
Echinococcus granulosus	zinc finger protein	0.0101	0.0665	0.0918
Schistosoma mansoni	hypothetical protein	0.0873	0.7025	1
Onchocerca volvulus		0.0151	0.1079	0.1313
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0034	0.0114	0.1806
Trichomonas vaginalis	penicillin-binding protein, putative	0.0151	0.1079	0.1079
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.1381	0.1966
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0188	0.1381	0.1826
Mycobacterium tuberculosis	Probable esterase LipL	0.0151	0.1079	0.1035
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0163	0.1177	0.1668
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0105	0.0703	0.093
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.0665	0.0879
Schistosoma mansoni	chromobox protein	0.0206	0.1533	0.2163
Loa Loa (eye worm)	CHromoDomain protein family member	0.0044	0.0195	0.0241
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0223	0.0119
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0665	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0364	0.283	0.3815
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0665	0.0925
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0126	0.1417
Plasmodium vivax	heterochromatin protein 1, putative	0.0034	0.0114	0.0729
Trichomonas vaginalis	D-aminoacylase, putative	0.0151	0.1079	0.1079
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0114
Brugia malayi	hypothetical protein	0.0173	0.1261	0.1663
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0644	0.0894
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.005	0.0246	0.0326
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0364	0.2834	1
Trichomonas vaginalis	hypothetical protein	0.0034	0.0114	0.0114
Trichomonas vaginalis	chromobox protein, putative	0.0034	0.0114	0.0114
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0106	0.012
Trichomonas vaginalis	chromobox protein, putative	0.0034	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0331	0.0429
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0223	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1014	0.1351
Mycobacterium tuberculosis	Probable reductase	0.0327	0.2533	0.2581
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.005	0.0246	0.0304
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0034	0.0114	0.0103
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0795	0.6384	0.9295
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0307	0.2364	0.3406
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.005	0.0246	0.1329
Plasmodium falciparum	glutathione reductase	0.0144	0.1018	1
Plasmodium falciparum	thioredoxin reductase	0.0144	0.1018	1
Mycobacterium tuberculosis	Conserved protein	0.0151	0.1079	0.1035
Onchocerca volvulus	Huntingtin homolog	0.0243	0.184	0.2339
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0106	0.0649
Echinococcus granulosus	carbonic anhydrase II	0.0214	0.1601	0.2289
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.1381	0.1945
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1601	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.005	0.0246	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0209	0.1561	0.2093
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0106	0.0092
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0088	0.0558	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0126	0.0147
Brugia malayi	M-phase phosphoprotein, mpp8	0.0034	0.0114	0.0103
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0665	0.0918
Schistosoma mansoni	lamin	0.0105	0.0703	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0239	0.03
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0114	0.0131
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0972	0.1368
Toxoplasma gondii	NADPH-glutathione reductase	0.005	0.0246	0.1996
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.1381	0.1966
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0163	0.1177	0.1668
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0631	0.0869
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0024	0.0009
Schistosoma mansoni	hypothetical protein	0.0079	0.0484	0.0666
Onchocerca volvulus		0.0047	0.0223	0.0159
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0151	0.1079	0.0984
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0039	0.016	0.1241
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0163	0.1177	0.1654
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.005	0.0246	0.1536
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0214	0.1601	0.2126
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0114	0.0778	0.1083
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0113	0.0769	0.107
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0094	0.0614	0.0843
Schistosoma mansoni	carbonic anhydrase	0.0101	0.0665	0.0925
Schistosoma mansoni	hypothetical protein	0.0095	0.0616	0.0855
Trichomonas vaginalis	chromobox protein, putative	0.0034	0.0114	0.0114

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 7.4 nM	Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	ChEMBL.	19773173
Ki (binding)	= 63 nM	Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	ChEMBL.	19773173
Ki (binding)	= 0.109 uM	Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay	ChEMBL.	19651511
Ki (binding)	= 7.4 uM	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay	ChEMBL.	19651511
Ki (binding)	= 63 uM	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay	ChEMBL.	19651511

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL569350

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1067261