Detailed information for compound 1088813

Basic information

Technical information
  • TDR Targets ID: 1088813
  • Name: methyl 4-[3-(2,5-dimethoxyphenyl)-3-oxoprop-1 -enyl]benzoate
  • MW: 326.343 | Formula: C19H18O5
  • H donors: 0 H acceptors: 2 LogP: 3.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)C(=O)/C=C/c1ccc(cc1)C(=O)OC)OC
  • InChi: 1S/C19H18O5/c1-22-15-9-11-18(23-2)16(12-15)17(20)10-6-13-4-7-14(8-5-13)19(21)24-3/h4-12H,1-3H3/b10-6+
  • InChiKey: KGDRLXFEHIQGHY-UXBLZVDNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-[(E)-3-(2,5-dimethoxyphenyl)-3-oxoprop-1-enyl]benzoate
  • methyl 4-[3-(2,5-dimethoxyphenyl)-3-oxo-prop-1-enyl]benzoate
  • methyl 4-[(E)-3-(2,5-dimethoxyphenyl)-3-oxo-prop-1-enyl]benzoate
  • 4-[(E)-3-(2,5-dimethoxyphenyl)-3-oxoprop-1-enyl]benzoic acid methyl ester
  • 4-[3-(2,5-dimethoxyphenyl)-3-oxoprop-1-enyl]benzoic acid methyl ester
  • 4-[3-(2,5-dimethoxyphenyl)-3-keto-prop-1-enyl]benzoic acid methyl ester
  • 4-[(E)-3-(2,5-dimethoxyphenyl)-3-keto-prop-1-enyl]benzoic acid methyl ester
  • ZINC05129436

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0303 0.2176 0.2176
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Brugia malayi RNA, U transporter 1 0.0081 0.0503 0.1307
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.1085 0.2752
Leishmania major hypothetical protein, conserved 0.0071 0.0426 0.1026
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Schistosoma mansoni tubulin subunit gamma 0.0318 0.2286 0.2286
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Trichomonas vaginalis tubulin, putative 0.0526 0.3849 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0035 0.0035
Echinococcus multilocularis pyruvate kinase 0.0033 0.014 0.014
Echinococcus multilocularis geminin 0.0165 0.1134 0.1134
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0426 0.0426
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0109 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.023 0.023
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0158 0.1085 0.2752
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Mycobacterium ulcerans hypothetical protein 0.0071 0.0426 0.381
Echinococcus multilocularis tubulin subunit TubB 0.0388 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0033 0.014 0.0364
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.281 0.281
Leishmania major importin beta-1 subunit, putative 0.0023 0.0069 0.0089
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0988 0.0988
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0899 0.2266
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Schistosoma mansoni tubulin subunit alpha 0.0388 0.281 0.281
Trypanosoma cruzi tubulin delta chain 0.0296 0.2117 0.5458
Echinococcus multilocularis tubulin gamma 1 chain 0.0318 0.2286 0.2286
Loa Loa (eye worm) hypothetical protein 0.0431 0.3133 0.814
Plasmodium vivax delta tubulin, putative 0.0134 0.0899 0.2294
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0426 0.1204
Loa Loa (eye worm) tubulin alpha-2 chain 0.0388 0.281 0.73
Brugia malayi PHD-finger family protein 0.0028 0.0109 0.0282
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0011
Trypanosoma cruzi tubulin delta chain 0.0296 0.2117 0.5458
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0426 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0117 0.0304
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0814 0.0814
Leishmania major pyruvate kinase 0.0033 0.014 0.0276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0207 0.0451
Echinococcus multilocularis Tubulin beta 2C chain 0.0526 0.3849 0.3849
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0955 0.2481
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0053 0.0083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.026 0.0675
Brugia malayi beta-lactamase family protein 0.0071 0.0426 0.1108
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0036
Schistosoma mansoni survival motor neuron protein 0.0094 0.0605 0.0605
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0117 0.0117
Leishmania major beta tubulin 0.0526 0.3849 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0426 0.1058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0117 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0426 0.381
Loa Loa (eye worm) tubulin beta chain 0.0134 0.0899 0.2337
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.1806 0.4692
Echinococcus granulosus Tubulin beta 2C chain 0.0526 0.3849 0.3849
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0117 0.0304
Schistosoma mansoni jumonji domain containing protein 0.0074 0.045 0.045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0127 0.0276
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Giardia lamblia Delta tubulin 0.0134 0.0899 0.2294
Trypanosoma brucei beta tubulin 0.0292 0.2089 0.5384
Giardia lamblia Alpha-tubulin 0.0388 0.281 0.7285
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0944 0.2383
Brugia malayi hypothetical protein 0.0431 0.3133 0.814
Onchocerca volvulus Alhambra homolog 0.0028 0.0109 0.0347
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0151 0.0305
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0336 0.0872
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0114 0.0114
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0261 0.0678
Brugia malayi hypothetical protein 0.0119 0.0791 0.2055
Brugia malayi tubulin alpha-2 chain 0.0388 0.281 0.73
Onchocerca volvulus 0.0026 0.0093 0.0296
Brugia malayi Pre-SET motif family protein 0.0031 0.0127 0.033
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.2286 0.5901
Trypanosoma brucei beta tubulin 0.0526 0.3849 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0109 0.0229
Trypanosoma cruzi tubulin gamma chain 0.0318 0.2286 0.5901
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0069 0.0089
Brugia malayi Cell division protein ftsZ 0.0134 0.0899 0.2337
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0426 0.1108
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0137
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.014 0.0311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0117 0.0117
Echinococcus granulosus alpha tubulin 0.0388 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Toxoplasma gondii exonuclease III APE 0.0019 0.0035 0.0036
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.5823 0.5823
Leishmania major gamma-tubulin 0.0318 0.2286 0.5901
Brugia malayi beta-NAC-like protein 0.0034 0.0151 0.0393
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0955 0.0955
Loa Loa (eye worm) acetyltransferase 0.0141 0.0955 0.2481
Brugia malayi hypothetical protein 0.0463 0.3376 0.877
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0378 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.033
Echinococcus granulosus tubulin beta 1 chain 0.0526 0.3849 0.3849
Toxoplasma gondii beta-1 tubulin, putative 0.0526 0.3849 1
Giardia lamblia Gamma tubulin 0.0318 0.2286 0.5916
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.0035
Trypanosoma brucei beta tubulin 0.0526 0.3849 1
Brugia malayi Muscleblind-like protein 0.0145 0.0988 0.2566
Echinococcus multilocularis Tubulin beta 2C chain 0.0526 0.3849 0.3849
Leishmania major beta tubulin 0.0526 0.3849 1
Trichomonas vaginalis ran, putative 0.0021 0.0053 0.0047
Schistosoma mansoni tubulin subunit epsilon 0.0318 0.2283 0.2283
Schistosoma mansoni alpha tubulin 0.0388 0.281 0.281
Brugia malayi nuclear hormone receptor 0.0029 0.0117 0.0304
Echinococcus granulosus tubulin subunit beta 0.0526 0.3849 0.3849
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0117 0.0117
Echinococcus granulosus snurportin 1 0.0303 0.2176 0.2176
Mycobacterium ulcerans pyruvate kinase 0.0033 0.014 0.1025
Entamoeba histolytica hypothetical protein 0.007 0.0421 0.1012
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2176 0.5653
Echinococcus granulosus beta tubulin 0.0526 0.3849 0.3849
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.2283 0.5893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0117 0.0304
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0013 0.0033
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0093 0.0241
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0013 0.0013
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.281 0.73
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0066 0.0172
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0117 0.0304
Giardia lamblia Beta tubulin 0.0526 0.3849 1
Plasmodium falciparum alpha tubulin 2 0.0388 0.281 0.7285
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0254 0.1806 0.4692
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.0376
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0134 0.0899 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0426 0.1108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1062 0.3159
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0117 0.0304
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0033
Trichomonas vaginalis tubulin, putative 0.0158 0.1085 0.2752
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Trypanosoma brucei tubulin gamma chain 0.0318 0.2286 0.5901
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.014 0.0276
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0127 0.0127
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0207 0.0207
Echinococcus granulosus pyruvate kinase 0.0033 0.014 0.014
Echinococcus granulosus tubulin epsilon chain 0.0318 0.2283 0.2283
Brugia malayi Tubulin alpha-2 chain 0.0388 0.281 0.73
Echinococcus multilocularis tubulin subunit beta 0.0526 0.3849 0.3849
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.281 0.7285
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0035 0.0091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0117 0.0117
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.281 0.281
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0106 0.0274
Trypanosoma cruzi alpha tubulin, putative 0.0388 0.281 0.7275
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.014 0.0276
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.014 0.0364
Loa Loa (eye worm) hypothetical protein 0.023 0.1621 0.4211
Toxoplasma gondii beta tubulin 0.0526 0.3849 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0944 0.2383
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0119 0.0791 0.2055
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0378 0.09
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0035 0.0035
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0207 0.0452
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0117 0.0117
Brugia malayi Importin beta-1 subunit 0.0028 0.0109 0.0284
Echinococcus granulosus Tubulin beta 2C chain 0.0526 0.3849 0.3849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0011
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0241
Giardia lamblia Beta tubulin 0.0526 0.3849 1
Onchocerca volvulus 0.0031 0.0127 0.0405
Schistosoma mansoni hypothetical protein 0.0094 0.0605 0.0605
Schistosoma mansoni cpg binding protein 0.003 0.0117 0.0117
Echinococcus granulosus Tubulin beta 2C chain 0.0526 0.3849 0.3849
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0035 0.0091
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.281 0.7275
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0109 0.0109
Brugia malayi hypothetical protein 0.0016 0.0013 0.0033
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Giardia lamblia Epsilon tubulin 0.0159 0.1094 0.2802
Entamoeba histolytica Ran family GTPase 0.0021 0.0053 0.0047
Giardia lamblia Alpha-tubulin 0.0388 0.281 0.7285
Schistosoma mansoni cpg binding protein 0.0028 0.0106 0.0106
Onchocerca volvulus 0.0071 0.0426 0.1361
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0109 0.0109
Leishmania major beta tubulin 0.0526 0.3849 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0106 0.0274
Trypanosoma brucei alpha tubulin 0.0388 0.281 0.7275
Schistosoma mansoni importin beta-1 0.0028 0.0109 0.0109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0426 0.381
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0899 0.2266
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0172
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.281 0.281
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0033 0.0145 0.0145
Schistosoma mansoni lozenge 0.0054 0.0302 0.0302
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0426 0.1026
Onchocerca volvulus 0.0028 0.0106 0.0337
Echinococcus multilocularis musashi 0.0026 0.0093 0.0093
Trypanosoma brucei alpha tubulin, putative 0.0158 0.1085 0.2752
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0117 0.0304
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0093 0.0241
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0109 0.023
Leishmania major beta tubulin 0.0526 0.3849 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0038 0.0098
Schistosoma mansoni hypothetical protein 0.0398 0.2885 0.2885
Loa Loa (eye worm) pyruvate kinase 0.0033 0.014 0.0364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0165 0.1134 0.1134
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0117 0.0304
Brugia malayi Tubulin gamma chain 0.0318 0.2286 0.5938
Leishmania major beta tubulin 0.0526 0.3849 1
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0117 0.0304
Schistosoma mansoni lamin 0.0026 0.0093 0.0093
Echinococcus granulosus beta tubulin 0.0526 0.3849 0.3849
Onchocerca volvulus 0.0158 0.1085 0.3462
Entamoeba histolytica tubulin alpha-1 chain 0.0388 0.281 0.7275
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0117 0.0304
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0127 0.0127
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0159 0.1094 0.2802
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0207 0.0451
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0814 0.0814
Echinococcus multilocularis Tubulin beta 2C chain 0.0526 0.3849 0.3849
Echinococcus granulosus pyruvate kinase 0.0017 0.0021 0.0021
Trichomonas vaginalis tubulin, putative 0.0158 0.1085 0.2752
Echinococcus multilocularis hypothetical protein 0.0388 0.281 0.281
Trichomonas vaginalis tubulin epsilon chain, putative 0.0526 0.3849 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.281 0.281
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.014 0.0447
Brugia malayi Bromodomain containing protein 0.0032 0.0135 0.035
Plasmodium falciparum phd finger protein, putative 0.0028 0.0109 0.0229
Onchocerca volvulus 0.0094 0.0605 0.1932
Loa Loa (eye worm) beta-tubulin 0.0526 0.3849 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.3286 1
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0117 0.0117
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0151 0.0305
Mycobacterium leprae cell division protein FtsZ 0.0134 0.0899 1
Brugia malayi Tubulin beta chain 0.0134 0.0899 0.2337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0117 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0117 0.0117
Brugia malayi beta-lactamase 0.0071 0.0426 0.1108
Mycobacterium tuberculosis Cell division protein FtsZ 0.0134 0.0899 0.2659
Echinococcus granulosus intermediate filament protein 0.0026 0.0093 0.0093
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0426 0.1204
Brugia malayi hypothetical protein 0.0016 0.0013 0.0033
Plasmodium vivax SET domain protein, putative 0.0031 0.0127 0.0276
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0117 0.0304
Echinococcus multilocularis tubulin beta 1 chain 0.0526 0.3849 0.3849
Giardia lamblia Beta tubulin 0.0526 0.3849 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0151 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0117 0.0304
Brugia malayi Tubulin alpha chain 0.0388 0.281 0.73
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0195
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0089
Entamoeba histolytica tubulin alpha chain, putative 0.0388 0.281 0.7275
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0328 0.0801
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0207 0.0452
Trypanosoma brucei epsilon tubulin 0.0318 0.2283 0.5893
Trichomonas vaginalis tubulin epsilon chain, putative 0.0526 0.3849 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.0791 0.2525
Loa Loa (eye worm) hypothetical protein 0.0145 0.0988 0.2566
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0117 0.0373
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0207 0.0486
Loa Loa (eye worm) BEN-1 protein 0.0526 0.3849 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.026 0.0675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.023 0.023
Brugia malayi jmjC domain containing protein 0.0093 0.0594 0.1542
Brugia malayi hypothetical protein 0.007 0.0421 0.1094
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.3376 0.3376
Echinococcus multilocularis tubulin alpha chain 0.0388 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Trichomonas vaginalis tubulin, putative 0.016 0.1096 0.2783
Entamoeba histolytica hypothetical protein 0.0034 0.0151 0.0305
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0151 0.034
Treponema pallidum cell division protein FtsZ 0.0134 0.0899 1
Brugia malayi Tubulin alpha-2 chain 0.0388 0.281 0.73
Echinococcus multilocularis beta tubulin 0.0526 0.3849 0.3849
Entamoeba histolytica tubulin family protein 0.0526 0.3849 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.026 0.0675
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2885 0.2885
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.1035 0.1035
Brugia malayi tubulin alpha chain - mouse 0.0388 0.281 0.73
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0011
Leishmania major beta tubulin 0.0526 0.3849 1
Trypanosoma brucei epsilon tubulin 0.0292 0.2089 0.5384
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.0089
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0426 0.1204
Schistosoma mansoni tubulin subunit alpha 0.0388 0.281 0.281
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.281 0.281
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0181 0.0418
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0426 0.1204
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0155 0.1062 1
Echinococcus multilocularis cpg binding protein 0.003 0.0117 0.0117
Leishmania major pyruvate kinase 0.0033 0.014 0.0276
Echinococcus granulosus geminin 0.0165 0.1134 0.1134
Onchocerca volvulus 0.0071 0.0426 0.1361
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0083
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0594 0.0594
Onchocerca volvulus 0.024 0.1699 0.5423
Plasmodium vivax tubulin beta chain, putative 0.0526 0.3849 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0089
Loa Loa (eye worm) hypothetical protein 0.0431 0.3133 0.814
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.1345 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0166 0.0166
Echinococcus multilocularis lamin dm0 0.0026 0.0093 0.0093
Echinococcus multilocularis tubulin epsilon chain 0.0318 0.2283 0.2283
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.014 0.0276
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0117 0.0117
Brugia malayi steroid hormone receptor 0.0029 0.0117 0.0304
Echinococcus granulosus tubulin alpha chain 0.0388 0.281 0.281
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0028
Echinococcus multilocularis muscleblind protein 0.0145 0.0988 0.0988
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0207 0.0451
Trypanosoma brucei tubulin delta chain 0.0296 0.2117 0.5458
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0117 0.0117
Echinococcus granulosus lamin 0.0026 0.0093 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0944 0.2383
Plasmodium falciparum tubulin gamma chain 0.0318 0.2286 0.5916
Leishmania major beta tubulin 0.0526 0.3849 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.023 0.0597
Mycobacterium tuberculosis Conserved protein 0.0071 0.0426 0.1204
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0207 0.0486
Trypanosoma brucei pyruvate kinase 1 0.0033 0.014 0.0276
Plasmodium vivax tubulin gamma chain, putative 0.0318 0.2286 0.5916
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0426 0.1204
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0013 0.0033
Leishmania major basic transcription factor 3a, putative 0.0034 0.0151 0.0305
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0426 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0117 0.0304
Entamoeba histolytica hypothetical protein 0.007 0.0421 0.1012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0117 0.0117
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Echinococcus multilocularis pyruvate kinase 0.0026 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0117 0.0304
Trichomonas vaginalis tubulin gamma chain, putative 0.0134 0.0899 0.2266
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0013 0.0013
Loa Loa (eye worm) BEN-1 protein 0.0526 0.3849 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0175 0.0175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0349 0.0349
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0378 0.0378
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0175 0.0175
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0066 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0117 0.0304
Loa Loa (eye worm) tubulin beta-1 chain 0.0526 0.3849 1
Brugia malayi beta-tubulin, identical 0.0526 0.3849 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.281 0.7275
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0426 0.1026
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0109 0.0282
Schistosoma mansoni tubulin subunit alpha 0.0388 0.281 0.281
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0378 0.0378
Toxoplasma gondii ABC1 family protein 0.0071 0.0426 0.1058
Trichomonas vaginalis tubulin epsilon chain, putative 0.0134 0.0899 0.2266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.211 0.5441
Brugia malayi nuclear receptor NHR-88 0.0029 0.0117 0.0304
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1035 0.1035
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.281 0.281
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0117 0.0117
Loa Loa (eye worm) alpha-tubulin 0.0388 0.281 0.73
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.281 0.281
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0207 0.0486
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.023 0.0597
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0296 0.2117 0.5474
Onchocerca volvulus 0.0026 0.0093 0.0296
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0463 0.3376 0.877
Schistosoma mansoni cpg binding protein 0.003 0.0117 0.0117
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus granulosus tubulin alpha chain 0.0388 0.281 0.281
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0605 0.1573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.023 0.023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0013 0.0013
Loa Loa (eye worm) tubulin beta chain 0.0526 0.3849 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.014 0.0311
Echinococcus multilocularis tubulin alpha chain 0.0388 0.281 0.281
Mycobacterium tuberculosis Conserved protein 0.0071 0.0426 0.1204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.023 0.023
Leishmania major zeta tubulin, putative 0.0404 0.2934 0.7602
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.281 0.281
Trypanosoma brucei beta tubulin 0.0526 0.3849 1
Echinococcus multilocularis microtubule associated protein 2 0.1345 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.281 0.281
Schistosoma mansoni transcription factor btf3 0.0034 0.0151 0.0151
Trichomonas vaginalis tubulin beta chain, putative 0.0526 0.3849 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0151 0.0393
Toxoplasma gondii alpha tubulin TUBA1 0.0388 0.281 0.7285
Echinococcus granulosus cpg binding protein 0.003 0.0117 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0426 0.1204
Brugia malayi jmjC domain containing protein 0.0036 0.0166 0.043
Schistosoma mansoni hypothetical protein 0.0122 0.0814 0.0814
Plasmodium falciparum tubulin beta chain 0.0526 0.3849 1
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0109 0.0229
Schistosoma mansoni pyruvate kinase 0.0033 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0145 0.0988 0.2566
Brugia malayi Pre-SET motif family protein 0.0211 0.1481 0.3847
Plasmodium vivax tubulin epsilon chain, putative 0.0318 0.2283 0.5908
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0151 0.034
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0378 0.0378
Giardia lamblia PHD finger protein 15 0.0028 0.0109 0.0229
Echinococcus multilocularis Tubulin beta 2C chain 0.0526 0.3849 0.3849
Schistosoma mansoni tubulin subunit delta 0.0134 0.0899 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0117 0.0304
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.211 0.5441
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0117 0.0117
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Loa Loa (eye worm) tubulin alpha 2 0.0096 0.0617 0.1603
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.023 0.023
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0134 0.0899 0.2266
Trypanosoma cruzi zeta tubulin, putative 0.0404 0.2934 0.7602
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.014 0.0447
Leishmania major GTP-binding protein, putative 0.0021 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Schistosoma mansoni pyruvate kinase 0.0033 0.014 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0117 0.0304
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0117 0.0117
Plasmodium falciparum importin beta, putative 0.0028 0.0109 0.023
Schistosoma mansoni hypothetical protein 0.0165 0.1134 0.1134
Echinococcus granulosus tubulin delta chain 0.0134 0.0899 0.0899
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0151 0.0305
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.281 0.281
Plasmodium falciparum pyruvate kinase 0.0033 0.014 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0426 0.1026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Brugia malayi ecdysteroid receptor 0.0029 0.0117 0.0304
Brugia malayi alpha-tubulin 0.0388 0.281 0.73
Echinococcus multilocularis tubulin alpha chain 0.0388 0.281 0.281
Schistosoma mansoni intermediate filament proteins 0.0026 0.0093 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0117 0.0117
Echinococcus granulosus peroxisome assembly protein 26 0.0388 0.281 0.281
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0117 0.0304
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Schistosoma mansoni tubulin subunit alpha 0.0134 0.0899 0.0899
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.1806 0.4692
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0594 0.0594
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.281 0.281
Trypanosoma brucei epsilon tubulin 0.0318 0.2283 0.5893
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.281 0.7285
Mycobacterium ulcerans cell division protein FtsZ 0.0134 0.0899 0.8416
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0426 0.0426
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0011 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.014 0.0447
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0195
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0117 0.0117
Trichomonas vaginalis tubulin beta chain, putative 0.0158 0.1085 0.2752
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0047
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0151 0.0305
Echinococcus granulosus peregrin 0.0032 0.0135 0.0135
Leishmania major beta tubulin 0.0526 0.3849 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0003
Echinococcus granulosus transcription factor btf3 0.0034 0.0151 0.0151
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0117 0.0373
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0151 0.034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0378 0.09
Loa Loa (eye worm) pyruvate kinase 0.0033 0.014 0.0364
Brugia malayi Tubulin beta chain 0.0158 0.1085 0.2818
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0526 0.3849 0.3849
Chlamydia trachomatis pyruvate kinase 0.0033 0.014 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.0526 0.3849 0.3849
Echinococcus multilocularis Protein lozenge 0.0054 0.0302 0.0302
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.281 0.281
Echinococcus granulosus pyruvate kinase 0.0033 0.014 0.014
Loa Loa (eye worm) runx1 0.0054 0.0302 0.0784
Brugia malayi nuclear receptor RXR 0.0016 0.0013 0.0033
Onchocerca volvulus 0.0431 0.3133 1
Schistosoma mansoni alpha tubulin 0.0388 0.281 0.281
Leishmania major beta tubulin 0.0526 0.3849 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0117 0.0304
Echinococcus granulosus tubulin subunit TubB 0.0388 0.281 0.281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0117 0.0117
Mycobacterium leprae Probable lipase LipE 0.0071 0.0426 0.3769
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2885 0.2885
Toxoplasma gondii beta-tubulin, putative 0.0526 0.3849 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0151 0.0305
Plasmodium falciparum tubulin epsilon chain, putative 0.0318 0.2283 0.5908
Trypanosoma brucei alpha tubulin 0.0388 0.281 0.7275
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Plasmodium falciparum tubulin delta chain, putative 0.0134 0.0899 0.2294
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.211 0.5441
Echinococcus granulosus muscleblind protein 0.0145 0.0988 0.0988
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0109 0.0109
Leishmania major beta tubulin 0.0526 0.3849 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.1085 0.2752
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.023 0.023
Echinococcus granulosus tubulin gamma 1 chain 0.0318 0.2286 0.2286
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0292 0.2089 0.5401
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0426 0.1026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Echinococcus granulosus tubulin alpha chain 0.0388 0.281 0.281
Echinococcus multilocularis peregrin 0.0032 0.0135 0.0135
Trichomonas vaginalis tubulin gamma chain, putative 0.0526 0.3849 1
Schistosoma mansoni hypothetical protein 0.007 0.0421 0.0421
Brugia malayi Tubulin beta-1 chain 0.0526 0.3849 1
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.281 0.281
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.281 0.73
Echinococcus granulosus importin subunit beta 1 0.0028 0.0109 0.0109
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0145 0.0376
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0378 0.09
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0117 0.0117
Toxoplasma gondii tubulin, putative 0.0026 0.009 0.0179
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0378 0.0982
Echinococcus granulosus lamin dm0 0.0026 0.0093 0.0093
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0117 0.0373
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0421 0.0421
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.2283 0.5893
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0117 0.0304
Mycobacterium tuberculosis Conserved protein 0.0071 0.0426 0.1204
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0117 0.0304
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0304
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0275 0.063
Echinococcus multilocularis peroxisome assembly protein 26 0.0388 0.281 0.281
Toxoplasma gondii alpha-tubulin I, putative 0.0388 0.281 0.7285
Giardia lamblia Pyruvate kinase 0.0033 0.014 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0028 0.0109 0.0109
Trypanosoma brucei alpha tubulin 0.0388 0.281 0.7275
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0011 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0421 0.0421
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0093 0.0241
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0117 0.0117
Onchocerca volvulus 0.0029 0.0117 0.0373
Trichomonas vaginalis esterase, putative 0.0071 0.0426 0.1026
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Echinococcus multilocularis transcription factor btf3 0.0034 0.0151 0.0151
Trypanosoma brucei alpha tubulin 0.0388 0.281 0.7275
Echinococcus granulosus tubulin alpha chain 0.0388 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0282
Mycobacterium ulcerans lipase LipD 0.0071 0.0426 0.381
Schistosoma mansoni coup transcription factor 0.0029 0.0117 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1035 0.1035
Loa Loa (eye worm) pyruvate kinase 0.0033 0.014 0.0364
Echinococcus granulosus Tubulin beta 2C chain 0.0526 0.3849 0.3849
Onchocerca volvulus Huntingtin homolog 0.0119 0.0791 0.2525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0166 0.0166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0117 0.0117
Trypanosoma cruzi zeta tubulin, putative 0.0404 0.2934 0.7602
Echinococcus multilocularis tubulin alpha chain 0.0388 0.281 0.281
Echinococcus multilocularis Tubulin beta 2C chain 0.0526 0.3849 0.3849
Leishmania major alpha tubulin 0.0388 0.281 0.7275
Echinococcus multilocularis tubulin alpha 0.0292 0.2089 0.2089
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0181 0.0384
Loa Loa (eye worm) hypothetical protein 0.0119 0.0791 0.2055
Schistosoma mansoni alpha tubulin 0.0388 0.281 0.281
Mycobacterium ulcerans beta-lactamase 0.0071 0.0426 0.381
Trypanosoma brucei zeta tubulin, putative 0.0404 0.2934 0.7602
Loa Loa (eye worm) alpha-tubulin 0.0388 0.281 0.73
Echinococcus granulosus Tubulin beta 2C chain 0.0526 0.3849 0.3849
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0048 0.0253 0.0605
Loa Loa (eye worm) hypothetical protein 0.0048 0.026 0.0675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.023 0.023
Entamoeba histolytica hypothetical protein 0.007 0.0421 0.1012
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0426 0.1026
Loa Loa (eye worm) hypothetical protein 0.0388 0.281 0.73
Echinococcus multilocularis tubulin alpha chain 0.0388 0.281 0.281
Leishmania major epsilon tubulin, putative 0.0318 0.2283 0.5893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0232
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0053 0.0083
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Loa Loa (eye worm) tubulin beta-2A chain 0.0526 0.3849 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0117 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0013 0.0033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1481 0.3847
Plasmodium falciparum alpha tubulin 1 0.0388 0.281 0.7285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0117 0.0117
Entamoeba histolytica tubulin family protein 0.0526 0.3849 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0426 0.1026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0117 0.0117
Trichomonas vaginalis set domain proteins, putative 0.024 0.1699 0.4363
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.1085 0.2752
Trichomonas vaginalis tubulin alpha chain, putative 0.0526 0.3849 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Loa Loa (eye worm) tubulin gamma chain 0.0318 0.2286 0.5938
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0166 0.0166
Leishmania major beta tubulin 0.0526 0.3849 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0426 0.3769
Trichomonas vaginalis tubulin alpha chain, putative 0.0292 0.2089 0.5384
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.014 0.0276
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.014 0.0364
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0166 0.043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0083
Schistosoma mansoni tubulin subunit beta 0.0134 0.0899 0.0899
Trypanosoma brucei beta tubulin 0.0526 0.3849 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Brugia malayi intermediate filament protein 0.0026 0.0093 0.0241
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.2283 0.5893
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0378 0.09
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0035 0.0036
Echinococcus multilocularis pyruvate kinase 0.0017 0.0021 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0426 0.1204
Entamoeba histolytica hypothetical protein 0.007 0.0421 0.1012
Echinococcus multilocularis beta tubulin 0.0526 0.3849 0.3849
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0426 0.1026
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.3376 0.3376
Trypanosoma brucei zeta tubulin 0.0404 0.2934 0.7602
Loa Loa (eye worm) tubulin beta-4 chain 0.0526 0.3849 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.014 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0127 0.0127
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.281 0.281
Echinococcus granulosus tubulin alpha 0.0292 0.2089 0.2089
Leishmania major delta tubulin, putative 0.0296 0.2117 0.5458
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0426 0.1108
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0181 0.0418
Leishmania major beta tubulin 0.0526 0.3849 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0117 0.0117
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0117 0.0304
Onchocerca volvulus 0.0071 0.0426 0.1361
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0151 0.0305
Schistosoma mansoni lamin 0.0026 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0254 0.1806 0.4692
Entamoeba histolytica tubulin gamma chain 0.0318 0.2286 0.5901
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0284
Brugia malayi Tubulin alpha chain 0.0134 0.0899 0.2337
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.023 0.1621 0.4158
Trypanosoma cruzi beta tubulin, putative 0.0526 0.3849 1
Echinococcus multilocularis snurportin 1 0.0303 0.2176 0.2176
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0117 0.0117
Echinococcus multilocularis lamin 0.0026 0.0093 0.0093
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0378 0.09
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.014 0.0276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0127 0.0127
Plasmodium vivax importin-beta 2, putative 0.0028 0.0109 0.023
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0109 0.0229
Brugia malayi beta-lactamase family protein 0.0071 0.0426 0.1108
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.211 0.5441
Echinococcus multilocularis tubulin delta chain 0.0134 0.0899 0.0899
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0207 0.0451
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.281 0.7275
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0421 0.0421
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0955 0.0955
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0117 0.0304
Leishmania major beta tubulin 0.0526 0.3849 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0069 0.0089
Echinococcus granulosus tubulin alpha chain 0.0388 0.281 0.281
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0925 0.0925
Schistosoma mansoni tubulin subunit beta 0.0526 0.3849 0.3849
Loa Loa (eye worm) tubulin alpha-3 chain 0.023 0.1621 0.4211
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0254 0.1806 0.4644
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.014 0.0324
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0036
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0388 0.281 0.7275

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.85 uM Cytotoxicity against human PC3 cells after 72 hrs by MTT assay ChEMBL. 20199865

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20199865

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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