Detailed information for compound 1109110

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.498 | Formula: C21H25FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC(=O)NC[C@@H]1CCCc2c1ccc(c2)S(=O)(=O)c1cccc(c1)F)C
  • InChi: 1S/C21H25FN2O3S/c1-24(2)14-21(25)23-13-16-6-3-5-15-11-19(9-10-20(15)16)28(26,27)18-8-4-7-17(22)12-18/h4,7-12,16H,3,5-6,13-14H2,1-2H3,(H,23,25)/t16-/m0/s1
  • InChiKey: HGAWOQUMCZNLBM-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0381 0.3586 0.3586
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Echinococcus granulosus protein kinase C gamma type 0.0047 0.0148 0.0148
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0661 0.2038
Brugia malayi RNA binding protein 0.013 0.1002 0.1108
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0428 0.407 0.45
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0042 0.0101 0.0101
Schistosoma mansoni tyrosine kinase 0.0166 0.1375 0.2932
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.005 0.0178 0.2896
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0047 0.0148 0.0148
Echinococcus granulosus CDC7 cell division cycle 7 0.0124 0.0944 0.0944
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0661 0.141
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0091 0.0602 0.251
Loa Loa (eye worm) TAR-binding protein 0.013 0.1002 0.1108
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1005 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0661 0.2808
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.009 0.0597 0.0597
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0998 0.9938 0.9938
Brugia malayi Fibronectin type III domain containing protein 0.0076 0.0448 0.0495
Brugia malayi SRC-1 0.0042 0.0101 0.0112
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0036 0.0041 0.0041
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0661 0.0731
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0178 0.0615
Brugia malayi p70 ribosomal S6 kinase beta 0.0116 0.0857 0.0947
Schistosoma mansoni histone deacetylase 0.0067 0.036 0.0768
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Loa Loa (eye worm) cytochrome P450 family protein 0.0132 0.1024 0.1132
Echinococcus granulosus geminin 0.0175 0.1465 0.1465
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.005 0.0178 0.0615
Echinococcus granulosus cyclin dependent kinase 0.0097 0.0661 0.0661
Echinococcus multilocularis insulin receptor 0.0381 0.3586 0.3586
Brugia malayi Furin-like cysteine rich region family protein 0.0442 0.421 0.4654
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Brugia malayi Tyrosine-protein kinase abl-1 0.0042 0.0101 0.0112
Loa Loa (eye worm) hypothetical protein 0.0242 0.216 0.2388
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.005 0.0178 1
Entamoeba histolytica protein kinase, putative 0.0121 0.0913 0.2816
Entamoeba histolytica serine/threonine protein kinase, putative 0.0249 0.2234 0.6887
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0097 0.0661 0.0731
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0013
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0091 0.0602 0.251
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0348 0.3243 0.3585
Entamoeba histolytica protein kinase, putative 0.0106 0.0762 0.2349
Leishmania major protein kinase A catalytic subunit 0.0091 0.0602 0.251
Brugia malayi follicle stimulating hormone receptor 0.0246 0.2194 0.2426
Giardia lamblia Kinase, CMGC CLK 0.0254 0.2279 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.2933 0.3243
Echinococcus granulosus dual specificity protein kinase clk2 0.0254 0.2279 0.2279
Brugia malayi serine/threonine-protein kinase plk-2 0.0249 0.2234 0.2469
Schistosoma mansoni serine/threonine kinase 0.0047 0.0148 0.0316
Entamoeba histolytica hypothetical protein 0.0035 0.0031 0.0096
Echinococcus multilocularis geminin 0.0175 0.1465 0.1465
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.005 0.0178 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0091 0.0602 0.251
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0661 0.0731
Schistosoma mansoni inositol monophosphatase 0.0038 0.006 0.0128
Brugia malayi Histone deacetylase 1 0.0067 0.036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0091 0.0602 0.0666
Schistosoma mansoni protein kinase 0.0036 0.0041 0.0087
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.2279 1
Echinococcus multilocularis c src tyrosine kinase 0.0042 0.0101 0.0101
Entamoeba histolytica PH domain containing protein kinase, putative 0.0086 0.0552 0.1702
Echinococcus granulosus nervana 2 0.0069 0.0377 0.0377
Brugia malayi Cytochrome P450 family protein 0.0078 0.0469 0.0518
Schistosoma mansoni hypothetical protein 0.005 0.0178 0.038
Leishmania major protein kinase, putative 0.0254 0.2279 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0488 0.469 0.5185
Loa Loa (eye worm) hypothetical protein 0.009 0.0597 0.066
Loa Loa (eye worm) hypothetical protein 0.0067 0.036 0.0398
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.005 0.0178 0.2896
Schistosoma mansoni protein kinase 0.0036 0.0041 0.0087
Schistosoma mansoni tyrosine kinase 0.0381 0.3586 0.7646
Onchocerca volvulus 0.0124 0.0944 0.2013
Echinococcus multilocularis 0.005 0.0178 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0661 0.2773
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.005 0.0178 1
Schistosoma mansoni tyrosine kinase 0.0302 0.2779 0.5926
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Echinococcus multilocularis protein dispatched 1 0.0047 0.0154 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.2279 0.486
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0042 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0097 0.0661 0.0731
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0091 0.0602 0.1263
Leishmania major histone deacetylase, putative 0.0067 0.036 0.1428
Trypanosoma brucei cdc2-related kinase 1 0.0097 0.0661 0.2773
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0076 0.0448 0.0448
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0076 0.0448 0.0955
Echinococcus multilocularis protein kinase shaggy 0.0106 0.0762 0.0762
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0661 0.2039
Giardia lamblia Kinase, CMGC GSK 0.0106 0.0762 0.2093
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.006 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.005 0.0178 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0488 0.469 0.5185
Loa Loa (eye worm) hypothetical protein 0.0085 0.0543 0.06
Echinococcus multilocularis Immunoglobulin 0.0076 0.0448 0.0448
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0944 0.4065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.1002 0.1108
Brugia malayi Protein kinase domain containing protein 0.0488 0.469 0.5185
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0661 0.1569
Brugia malayi hypothetical protein 0.0076 0.0448 0.0495
Schistosoma mansoni serine/threonine-protein kinase 0.0086 0.0552 0.1177
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.018 0.1517 0.1677
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0254 0.2279 1
Toxoplasma gondii histone deacetylase HDAC2 0.0067 0.036 0.1428
Brugia malayi TAR-binding protein 0.013 0.1002 0.1108
Schistosoma mansoni hypothetical protein 0.0035 0.0031 0.0066
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0069 0.0377 0.0377
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0661 0.0661
Echinococcus granulosus NDR protein kinase 0.0047 0.0148 0.0148
Entamoeba histolytica protein kinase domain containing protein 0.0348 0.3243 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0124 0.094 0.094
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.006 0.0185
Echinococcus granulosus protein kinase c epsilon type 0.0047 0.0148 0.0148
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0223 0.1966 0.1966
Brugia malayi Protein kinase domain containing protein 0.0047 0.0148 0.0164
Echinococcus granulosus cyclin dependent kinase 1 0.0097 0.0661 0.0661
Echinococcus granulosus expressed conserved protein 0.0091 0.0601 0.0601
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0091 0.0602 0.251
Echinococcus granulosus hypothetical protein 0.0242 0.216 0.216
Echinococcus multilocularis neuroglian 0.0087 0.0565 0.0565
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0042 0.0101 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0674 0.1438
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.005 0.0178 0.2896
Echinococcus multilocularis histone deacetylase 1 0.0067 0.036 0.036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0235 0.2083 0.2303
Entamoeba histolytica histone deacetylase, putative 0.0067 0.036 0.111
Toxoplasma gondii AGC kinase 0.0116 0.0857 0.3645
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0661 0.2808
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Trichomonas vaginalis AGC family protein kinase 0.0091 0.0602 0.2546
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0047 0.0148 0.0148
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.006 0.0087
Brugia malayi Protein kinase domain containing protein 0.0418 0.3968 0.4387
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.0762 0.2349
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Trypanosoma cruzi histone deacetylase 1, putative 0.0067 0.036 0.1428
Loa Loa (eye worm) TK protein kinase 0.0235 0.2083 0.2303
Echinococcus granulosus Protein kinase C brain isozyme 0.0047 0.0148 0.0148
Echinococcus multilocularis protein kinase c epsilon type 0.0047 0.0148 0.0148
Schistosoma mansoni tyrosine kinase 0.0042 0.0101 0.0216
Echinococcus granulosus neuroglian 0.0087 0.0565 0.0565
Brugia malayi Protein kinase domain containing protein 0.0124 0.0944 0.1044
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0176 0.1477 0.1477
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0042 0.0101 0.0101
Onchocerca volvulus 0.0313 0.2888 0.6157
Loa Loa (eye worm) AGC/PKN protein kinase 0.0047 0.0148 0.0164
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.006 0.006
Echinococcus multilocularis Immunoglobulin 0.0076 0.0448 0.0448
Leishmania major protein kinase A catalytic subunit isoform 2 0.0091 0.0602 0.251
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0047 0.0148 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0762 0.3255
Trypanosoma cruzi Protein kinase B 0.0086 0.0552 0.2285
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0012 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Loa Loa (eye worm) hypothetical protein 0.0385 0.3633 0.4016
Echinococcus granulosus snurportin 1 0.0317 0.2933 0.2933
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.005 0.0178 0.2896
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2167 0.2396
Brugia malayi Protein kinase domain containing protein 0.0912 0.9045 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.005 0.0178 0.2896
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.005 0.0178 0.2896
Plasmodium vivax glycogen synthase kinase 3, putative 0.0106 0.0762 0.2093
Schistosoma mansoni tar DNA-binding protein 0.013 0.1002 0.2136
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0091 0.0602 0.251
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0661 0.2039
Brugia malayi Inositol-1 0.0038 0.006 0.0066
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Loa Loa (eye worm) hypothetical protein 0.0049 0.0171 0.0189
Echinococcus multilocularis cyclin dependent kinase 5 0.0097 0.0661 0.0661
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0116 0.0857 0.0947
Loa Loa (eye worm) histone deacetylase 3 0.0067 0.036 0.0398
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0039 0.0039
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0091 0.0602 0.0666
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0047 0.0148 0.0148
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.006 0.0087
Entamoeba histolytica protein kinase, putative 0.0121 0.0913 0.2816
Echinococcus multilocularis activin receptor type 0.0036 0.0041 0.0041
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.0762 0.0842
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0106 0.0762 0.1624
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.006 0.0135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0428 0.407 0.45
Entamoeba histolytica protein kinase 2, putative 0.008 0.0495 0.1527
Giardia lamblia Kinase, AGC PKA 0.008 0.0495 0.0704
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.005 0.0178 0.2896
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.005 0.0178 0.0615
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Echinococcus granulosus Glutaredoxin protein 5 0.0069 0.0377 0.0377
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0047 0.0148 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Plasmodium falciparum histone deacetylase 1 0.0067 0.036 0.1428
Entamoeba histolytica hypothetical protein 0.0035 0.0031 0.0096
Plasmodium falciparum protein kinase 5 0.0097 0.0661 0.2773
Echinococcus granulosus defective proboscis extension response 0.0076 0.0448 0.0448
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.005 0.0178 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Echinococcus multilocularis nervana 2 0.0069 0.0377 0.0377
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.008 0.0495 0.0704
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0047 0.0148 0.0164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0148 0.0164
Loa Loa (eye worm) hypothetical protein 0.0102 0.0714 0.079
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.005 0.0178 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0047 0.0148 0.0148
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.036 0.1469
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0661 0.2773
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0602 0.1285
Trypanosoma cruzi rac serine-threonine kinase, putative 0.008 0.0495 0.2031
Leishmania major protein kinase A catalytic subunit isoform 1 0.0091 0.0602 0.251
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.005 0.0178 1
Schistosoma mansoni nephrin 0.0087 0.0565 0.1205
Echinococcus granulosus epidermal growth factor receptor 0.0302 0.2779 0.2779
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0091 0.0602 0.251
Plasmodium vivax protein kinase Crk2 0.0097 0.0661 0.1569
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0223 0.1966 0.1966
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0036 0.0041 0.0041
Schistosoma mansoni vesicular amine transporter 0.0076 0.0448 0.0955
Loa Loa (eye worm) CDC7 protein kinase 0.0124 0.0944 0.1044
Leishmania major cytochrome p450-like protein 0.005 0.0178 0.0615
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0031 0.0031
Echinococcus granulosus Immunoglobulin 0.0076 0.0448 0.0448
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0168
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.005 0.0178 0.2896
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0069 0.0377 0.0377
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0042 0.0101 0.0216
Loa Loa (eye worm) SRC-1 0.0042 0.0101 0.0112
Brugia malayi cytochrome P450 0.005 0.0178 0.0197
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0381 0.3586 0.3586
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.036 0.1469
Trypanosoma cruzi histone deacetylase 1, putative 0.0067 0.036 0.1428
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.006 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.005 0.0178 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0254 0.2279 1
Entamoeba histolytica hypothetical protein 0.0035 0.0031 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.005 0.0178 1
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0168
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.036 0.1469
Schistosoma mansoni tar DNA-binding protein 0.013 0.1002 0.2136
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0469 0.0518
Loa Loa (eye worm) hypothetical protein 0.0385 0.3633 0.4016
Echinococcus granulosus nervana 2 0.0069 0.0377 0.0377
Echinococcus granulosus cyclin dependent kinase 5 0.0097 0.0661 0.0661
Giardia lamblia Kinase, AGC PKA 0.0091 0.0602 0.1263
Brugia malayi Protein kinase domain containing protein 0.0169 0.1402 0.155
Trypanosoma brucei cdc2-related kinase 3 0.0097 0.0661 0.2773
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0488 0.469 0.469
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.005 0.0178 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0223 0.1966 0.1966
Schistosoma mansoni hypothetical protein 0.0317 0.2933 0.6254
Schistosoma mansoni tar DNA-binding protein 0.013 0.1002 0.2136
Entamoeba histolytica protein kinase, putative 0.0047 0.0148 0.0457
Brugia malayi Cytochrome P450 family protein 0.0132 0.1024 0.1132
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0661 0.0731
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.0148 0.0148
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0148 0.0527
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0079 0.0484 0.0484
Trypanosoma brucei protein kinase, putative 0.0106 0.0762 0.3222
Echinococcus multilocularis protein patched 0.0041 0.0094 0.0094
Leishmania major histone deacetylase, putative 0.0067 0.036 0.1428
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.005 0.0178 1
Brugia malayi Hr1 repeat family protein 0.0047 0.0148 0.0164
Loa Loa (eye worm) AGC/PKA protein kinase 0.0091 0.0602 0.0666
Plasmodium falciparum glycogen synthase kinase 3 0.0106 0.0762 0.3222
Loa Loa (eye worm) cytochrome P450 0.005 0.0178 0.0197
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0469 0.0518
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0944 0.4065
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Loa Loa (eye worm) inositol-1 0.0038 0.006 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.008 0.0495 0.2031
Echinococcus granulosus twitchin 0.0099 0.0684 0.0684
Schistosoma mansoni inositol monophosphatase 0.0038 0.006 0.0128
Brugia malayi CHE-14 protein 0.0041 0.0094 0.0104
Mycobacterium leprae putative cytochrome p450 0.005 0.0178 1
Onchocerca volvulus 0.0289 0.2644 0.5638
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0254 0.2279 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.005 0.0178 0.2896
Giardia lamblia Kinase, CMGC GSK 0.0106 0.0762 0.2093
Echinococcus multilocularis 0.0128 0.098 0.098
Echinococcus granulosus serine:threonine protein kinase N2 0.0047 0.0148 0.0148
Schistosoma mansoni cytochrome P450 0.005 0.0178 0.038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0031 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.005 0.0178 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0091 0.0602 0.251
Echinococcus granulosus tar DNA binding protein 0.013 0.1002 0.1002
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1087 0.1087
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Schistosoma mansoni tyrosine kinase 0.0051 0.0188 0.0402
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0047 0.0148 0.0164
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0091 0.0602 0.251
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0042 0.0101 0.0101
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0047 0.0148 0.0148
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0254 0.2279 1
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.2234 0.4763
Brugia malayi Cytochrome P450 family protein 0.005 0.0178 0.0197
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0106 0.0762 0.3222
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0047 0.0148 0.0148
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0348 0.3243 0.3243
Echinococcus granulosus fibroblast growth factor receptor 4 0.0223 0.1966 0.1966
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.005 0.0178 0.2896
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.075 0.3203
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0094 0.0094
Schistosoma mansoni tyrosine kinase 0.0042 0.0101 0.0216
Brugia malayi intracellular kinase 0.0106 0.0762 0.0842
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.2763 0.5891
Echinococcus granulosus c src tyrosine kinase 0.0042 0.0101 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0148 0.0527
Brugia malayi Protein kinase domain containing protein 0.0254 0.2279 0.252
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0913 0.3929
Brugia malayi Protein kinase domain containing protein 0.0047 0.0148 0.0164
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0076 0.0448 0.0955
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0148 0.0527
Echinococcus multilocularis rho associated protein kinase 0.0301 0.2763 0.2763
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.006 0.0135
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0348 0.3243 0.3243
Trypanosoma brucei polo-like protein kinase 0.0249 0.2234 0.9797
Echinococcus multilocularis roundabout 2 0.0102 0.0714 0.0714
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0254 0.2279 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0674 0.0746
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0254 0.2279 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0661 0.0661
Onchocerca volvulus Serine\/threonine kinase homolog 0.0249 0.2234 0.4763
Loa Loa (eye worm) histone deacetylase 1 0.0067 0.036 0.0398
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0097 0.0661 0.2773
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0661 0.0661
Brugia malayi histone deacetylase 1 (HD1) 0.0067 0.036 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0023 0.005
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0176 0.1477 0.1477
Schistosoma mansoni cell adhesion molecule 0.009 0.0597 0.1274
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.005 0.0178 0.2896
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.008 0.0495 0.0495
Schistosoma mansoni tyrosine kinase 0.0381 0.3586 0.7646
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0106 0.0762 0.3222
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0097 0.0661 0.2773
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0094 0.0104
Echinococcus granulosus rho-associated protein kinase 1 0.0301 0.2763 0.2763
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0469 0.1912
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0171 0.0189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0171 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2167 0.2396
Schistosoma mansoni atypical protein kinase C 0.0047 0.0148 0.0316
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.0448 0.0495
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0674 0.0674
Brugia malayi hypothetical protein 0.0035 0.0031 0.0034
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0039 0.0039
Plasmodium vivax serine/threonine kinase-1, putative 0.0254 0.2279 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0254 0.2279 0.252
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.006 0.0135
Echinococcus granulosus activin receptor type 0.0036 0.0041 0.0041
Trypanosoma brucei rac serine-threonine kinase, putative 0.0121 0.0913 0.3899
Brugia malayi RNA, U transporter 1 0.0085 0.0538 0.0595
Schistosoma mansoni tar DNA-binding protein 0.013 0.1002 0.2136
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0106 0.0762 0.0762
Echinococcus granulosus cytochrome P450 2K1 0.005 0.0178 0.0178
Echinococcus multilocularis cyclin dependent kinase 0.0097 0.0661 0.0661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0674 0.1438
Echinococcus multilocularis epidermal growth factor receptor 0.0442 0.421 0.421
Schistosoma mansoni tyrosine kinase 0.0278 0.2526 0.5385
Entamoeba histolytica protein kinase domain containing protein 0.0036 0.0041 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0661 0.141
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0168
Schistosoma mansoni histone deacetylase 0.0067 0.036 0.0768
Schistosoma mansoni tyrosine kinase 0.0042 0.0101 0.0216
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0488 0.469 0.5185
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.006 0.0087
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0249 0.2234 0.9797
Loa Loa (eye worm) RNA binding protein 0.013 0.1002 0.1108
Echinococcus granulosus serine threonine protein kinase nrc 0.008 0.0495 0.0495
Toxoplasma gondii AGC kinase 0.0091 0.0602 0.251
Giardia lamblia Kinase, CDC7 0.0124 0.0944 0.3043
Schistosoma mansoni tyrosine kinase 0.0278 0.2526 0.5385
Schistosoma mansoni patched 1 0.0041 0.0094 0.0201
Entamoeba histolytica protein kinase, putative 0.0116 0.0857 0.2641
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0042 0.0101 0.0101
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0661 0.2808
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0042 0.0101 0.0101
Onchocerca volvulus Huntingtin homolog 0.0385 0.3633 0.7746
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0097 0.0661 0.2773
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.005 0.0178 1
Schistosoma mansoni tyrosine kinase 0.0302 0.2779 0.5926
Loa Loa (eye worm) AGC/AKT protein kinase 0.0121 0.0913 0.101
Schistosoma mansoni kinase 0.0268 0.2424 0.5168
Trypanosoma cruzi polo-like protein kinase, putative 0.0249 0.2234 0.9797
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0602 0.1285
Giardia lamblia Kinase, PLK 0.0249 0.2234 0.9763
Brugia malayi MH2 domain containing protein 0.0243 0.2167 0.2396
Echinococcus granulosus tyrosine protein kinase Src64B 0.0042 0.0101 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0674 0.0674
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0091 0.0602 0.0602
Onchocerca volvulus Tyrosine kinase homolog 0.0349 0.3258 0.6948
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.005 0.0178 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0042 0.0101 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0488 0.469 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.005 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.1148 0.127
Loa Loa (eye worm) TK/ALK protein kinase 0.0262 0.236 0.2609
Toxoplasma gondii histone deacetylase HDAC3 0.0067 0.036 0.1428
Loa Loa (eye worm) TK/EGFR protein kinase 0.0442 0.421 0.4654
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0674 0.1438
Echinococcus multilocularis CDC7 cell division cycle 7 0.0124 0.0944 0.0944
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0042 0.0101 0.0101
Echinococcus granulosus tyrosine protein kinase Src42A 0.0042 0.0101 0.0101
Brugia malayi RNA recognition motif domain containing protein 0.013 0.1002 0.1108
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.005 0.0178 1
Echinococcus multilocularis serine threonine protein kinase 0.0047 0.0148 0.0148
Echinococcus multilocularis dual specificity protein kinase clk2 0.0254 0.2279 0.2279
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0469 0.1912
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0661 0.1569
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0254 0.2279 1
Brugia malayi Protein kinase domain containing protein 0.0097 0.0661 0.0731
Schistosoma mansoni serine/threonine-protein kinase 0.0086 0.0552 0.1177
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0249 0.2234 0.2234
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0488 0.469 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0674 0.0674
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0249 0.2234 0.2234
Echinococcus multilocularis epidermal growth factor receptor 0.0302 0.2779 0.2779
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0094 0.0094
Brugia malayi Protein kinase domain containing protein 0.0121 0.0913 0.101
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0168
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.005 0.0178 0.2896
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0944 0.2013
Echinococcus granulosus protein kinase c iota type 0.0047 0.0148 0.0148
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.008 0.0495 0.0495
Schistosoma mansoni protein kinase 0.0036 0.0041 0.0087
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0348 0.3243 0.3585
Echinococcus multilocularis expressed conserved protein 0.0091 0.0601 0.0601
Entamoeba histolytica PH domain containing protein kinase, putative 0.0096 0.0659 0.2032
Trypanosoma cruzi polo-like protein kinase, putative 0.0249 0.2234 0.9797
Leishmania major cytochrome p450-like protein 0.005 0.0178 0.0615
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0249 0.2234 0.2469
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0079 0.0484 0.0484
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0469 0.1912
Brugia malayi Protein kinase domain containing protein 0.0262 0.2361 0.261
Echinococcus multilocularis protein kinase c iota type 0.0047 0.0148 0.0148
Echinococcus granulosus protein kinase shaggy 0.0106 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0209 0.1815 0.2006
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.0762 0.2349
Toxoplasma gondii AGC kinase 0.0091 0.0602 0.251
Schistosoma mansoni serine/threonine protein kinase 0.0348 0.3243 0.6915
Echinococcus multilocularis serine:threonine protein kinase N2 0.0047 0.0148 0.0148
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0469 0.0518
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0418 0.3968 0.4387
Entamoeba histolytica PH domain containing protein kinase, putative 0.0096 0.0659 0.2032
Echinococcus multilocularis tar DNA binding protein 0.013 0.1002 0.1002
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.005 0.0178 0.2896
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0488 0.469 0.469
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.006 0.0087
Entamoeba histolytica hypothetical protein 0.0035 0.0031 0.0096
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0078 0.0469 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0171 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0674 0.0674
Onchocerca volvulus Huntingtin homolog 0.0385 0.3633 0.7746
Schistosoma mansoni tyrosine kinase 0.0442 0.421 0.8977
Schistosoma mansoni hypothetical protein 0.0175 0.1465 0.3125
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0676 0.1442
Schistosoma mansoni tyrosine kinase 0.0278 0.2526 0.5385
Entamoeba histolytica PH domain containing protein kinase, putative 0.0086 0.0552 0.1702
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.005 0.0178 0.2896
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0047 0.0148 0.0148
Toxoplasma gondii cytochrome p450 superfamily protein 0.005 0.0178 0.0615
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Leishmania major protein kinase, putative 0.0254 0.2279 1
Echinococcus granulosus insulin receptor 0.0381 0.3586 0.3586
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Echinococcus granulosus histone deacetylase 3 0.0067 0.036 0.036
Echinococcus multilocularis Glutaredoxin protein 5 0.0069 0.0377 0.0377
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0661 0.2773
Brugia malayi protein kinase C II. 0.0047 0.0148 0.0164
Loa Loa (eye worm) AGC/NDR protein kinase 0.0047 0.0148 0.0164
Echinococcus granulosus histone deacetylase 1 0.0067 0.036 0.036
Onchocerca volvulus 0.0301 0.2763 0.5891
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.0762 0.0842
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0097 0.0661 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1517 0.3235
Trypanosoma cruzi cytochrome p450-like protein, putative 0.005 0.0178 0.0615
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1087 0.1087
Loa Loa (eye worm) hypothetical protein 0.0102 0.0714 0.079
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0124 0.094 0.094
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.005 0.0178 1
Brugia malayi Protein kinase domain containing protein 0.0381 0.3586 0.3965
Brugia malayi cell division control protein 2 homolog 0.0097 0.0661 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.005 0.0178 1
Echinococcus granulosus roundabout 2 0.0102 0.0714 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Schistosoma mansoni hypothetical protein 0.0175 0.1465 0.3125
Loa Loa (eye worm) TK/INSR protein kinase 0.0381 0.3586 0.3965
Echinococcus granulosus tyrosine protein kinase Fyn 0.0042 0.0101 0.0101
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0106 0.0762 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0094 0.0287
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.006 0.006
Echinococcus multilocularis rac serine:threonine kinase 0.0086 0.0552 0.0552
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0106 0.0762 0.3222
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0091 0.0602 0.251
Echinococcus multilocularis 0.0242 0.216 0.216
Echinococcus granulosus serine/threonine protein kinase 0.0086 0.0552 0.0552
Echinococcus multilocularis histone deacetylase 3 0.0067 0.036 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.075 0.3203
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.005 0.0178 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.005 0.0178 0.2896
Plasmodium falciparum protein serine/threonine kinase-1 0.0254 0.2279 1
Echinococcus multilocularis snurportin 1 0.0317 0.2933 0.2933
Schistosoma mansoni tar DNA-binding protein 0.013 0.1002 0.2136
Leishmania major cytochrome p450-like protein 0.0078 0.0469 0.1912
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.005 0.0178 0.2896
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.2194 0.2426
Brugia malayi histone deacetylase 3 (HD3) 0.0067 0.036 0.0398
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0912 0.9045 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0448 0.0495
Schistosoma mansoni tyrosine kinase 0.0042 0.0101 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0205 0.078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0094 0.0104
Brugia malayi Cytochrome P450 family protein 0.0078 0.0469 0.0518
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0094 0.0094
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0661 0.2773
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.2234 0.9798
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0674 0.0746
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.005 0.0178 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0053 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0944 0.4065
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.022 0.022
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0086 0.0552 0.2285
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.005 0.0178 0.2896
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.005 0.0178 0.2896
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Leishmania major lanosterol 14-alpha-demethylase, putative 0.005 0.0178 0.0615
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.036 0.1469
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0602 0.1285
Onchocerca volvulus 0.0124 0.0944 0.2013
Brugia malayi hypothetical protein 0.0385 0.3633 0.4016
Trypanosoma brucei histone deacetylase 1 0.0067 0.036 0.1428
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.005 0.0178 0.2896
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0302 0.2779 0.2779
Echinococcus multilocularis nervana 2 0.0069 0.0377 0.0377
Echinococcus granulosus epidermal growth factor receptor 0.0442 0.421 0.421
Schistosoma mansoni tyrosine kinase 0.0223 0.1966 0.4192
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.2279 0.486
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0039 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.021
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.005 0.0178 0.2896
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0148 0.0316
Mycobacterium leprae Conserved hypothetical protein 0.005 0.0178 1
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0762 0.3255
Onchocerca volvulus 0.0106 0.0762 0.1624
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0047 0.0148 0.0164
Loa Loa (eye worm) AGC/PKA protein kinase 0.0091 0.0602 0.0666
Brugia malayi Protein kinase domain containing protein 0.018 0.1517 0.1677

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 9.4 Displacement of [3H]LSD form human recombinant 5HT6 receptor ChEMBL. 20434910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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