Detailed information for compound 1118485

Basic information

Technical information
  • TDR Targets ID: 1118485
  • Name: 2,7-di(phenyl)-6-phenylsulfonylpyrazolo[1,5-a ]pyrimidine
  • MW: 411.476 | Formula: C24H17N3O2S
  • H donors: 0 H acceptors: 4 LogP: 4.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1cnc2n(c1c1ccccc1)nc(c2)c1ccccc1)c1ccccc1
  • InChi: 1S/C24H17N3O2S/c28-30(29,20-14-8-3-9-15-20)22-17-25-23-16-21(18-10-4-1-5-11-18)26-27(23)24(22)19-12-6-2-7-13-19/h1-17H
  • InChiKey: KHPCUWVZYLONPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,7-di(phenyl)-6-phenylsulfonyl-pyrazolo[1,5-a]pyrimidine
  • AJ-916/40876432
  • ZINC00988028

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0056 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0056 0.008
Brugia malayi CXXC zinc finger family protein 0.0028 0.0131 0.0202
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.038 0.0474
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0288 0.1859
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0285
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.008
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0178 0.1076
Schistosoma mansoni Smad4 0.0017 0.0014 0.002
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.0562 0.0868
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.3969 0.4946
Echinococcus granulosus geminin 0.0689 0.704 1
Echinococcus granulosus Smad4 0.0017 0.0014 0.002
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0178 0.0151
Echinococcus granulosus muscleblind protein 0.0635 0.6479 0.9204
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0178 0.1076
Trichomonas vaginalis esterase, putative 0.0152 0.1431 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0124 0.0693
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.034 0.3391 0.4816
Brugia malayi jmjC domain containing protein 0.02 0.1932 0.2982
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0479 0.3125
Schistosoma mansoni jumonji domain containing protein 0.0159 0.1502 0.2134
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0047 0.0058
Brugia malayi PHD-finger family protein 0.0022 0.0066 0.0102
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.0562 0.3724
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0593 0.0843
Brugia malayi PHD-finger family protein 0.0061 0.0479 0.074
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0014 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.139 0.1732
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.0087
Brugia malayi cytochrome P450 0.0032 0.0178 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0178 0.0151
Leishmania major hypothetical protein, conserved 0.0152 0.1431 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0834 0.5042
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1431 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0178 0.0151
Echinococcus granulosus smad 0.0017 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0479 0.3125
Brugia malayi Smad1 0.0017 0.0014 0.0022
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0022
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.005 0.0019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0152 0.1431 0.2209
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0022
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.005 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0456 0.0704
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0047 0.0067
Onchocerca volvulus 0.0028 0.0131 0.0543
Plasmodium vivax hypothetical protein, conserved 0.0152 0.1431 1
Trypanosoma brucei unspecified product 0.0043 0.0288 0.1742
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0178 0.1076
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0047 0.0067
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0288 0.0445
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Loa Loa (eye worm) hypothetical protein 0.0079 0.0664 0.1025
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.0562 0.2531
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0562 0.0868
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0664 0.4458
Loa Loa (eye worm) cytochrome P450 0.0032 0.0178 0.0275
Loa Loa (eye worm) hypothetical protein 0.0635 0.6479 1
Entamoeba histolytica protein kinase, putative 0.0069 0.0562 0.2531
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0147 0.1372 0.2117
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0288 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0056 0.0087
Brugia malayi hypothetical protein 0.0016 0.0006 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.139 0.1975
Echinococcus granulosus ferritin 0.0018 0.0027 0.0038
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0178 0.1076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Echinococcus multilocularis protein dispatched 1 0.0047 0.0327 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0593 0.0843
Loa Loa (eye worm) beta-lactamase 0.0152 0.1431 0.2209
Onchocerca volvulus 0.0152 0.1431 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0152 0.1431 0.1408
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0178 0.0948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.0087
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0047 0.0067
Brugia malayi serine/threonine kinase 12 0.0069 0.0562 0.0868
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0288 0.0262
Schistosoma mansoni apoferritin-2 0.0018 0.0027 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0056 0.0087
Trypanosoma brucei polo-like protein kinase 0.0147 0.1372 0.9572
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.0562 0.2531
Loa Loa (eye worm) hypothetical protein 0.0095 0.0834 0.1288
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0178 0.0151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0056 0.008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0152 0.1431 0.2209
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0178 0.1076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.139 0.2145
Schistosoma mansoni hypothetical protein 0.0032 0.0178 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.1431 0.2033
Mycobacterium ulcerans hypothetical protein 0.0152 0.1431 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.2384 0.3679
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.1599 0.1993
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0097 0.0364
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0834 0.1288
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0178 0.0151
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0147 0.1372 0.1949
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0056 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Brugia malayi Cytochrome P450 family protein 0.0059 0.0456 0.0704
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0664 0.0827
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0178 0.1076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0147 0.1372 0.1709
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0056 0.008
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0178 0.1076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0344 0.0531
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.085 0.1207
Brugia malayi serine/threonine-protein kinase plk-2 0.0147 0.1372 0.2117
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.063 0.0973
Leishmania major protein kinase, putative 0.0069 0.0562 0.3724
Schistosoma mansoni protein kinase 0.0069 0.0562 0.0799
Loa Loa (eye worm) hypothetical protein 0.0027 0.0119 0.0184
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0593 0.0916
Schistosoma mansoni jumonji domain containing protein 0.002 0.0047 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.0126 0.1159 0.1789
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0593 0.0843
Schistosoma mansoni ferritin 0.0018 0.0027 0.0038
Brugia malayi jmjC domain containing protein 0.002 0.0047 0.0072
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0456 0.2959
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.1431 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0479 0.074
Echinococcus multilocularis phd:f box containing protein 0.002 0.0047 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Entamoeba histolytica hypothetical protein 0.0112 0.1014 0.6695
Brugia malayi MH2 domain containing protein 0.0243 0.2384 0.3679
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.0562 0.3724
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0664 0.4458
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0014 0.0022
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0178 0.1076
Entamoeba histolytica protein kinase, putative 0.0069 0.0562 0.2531
Echinococcus multilocularis protein patched 0.0041 0.0267 0.0333
Schistosoma mansoni kinase 0.0485 0.4906 0.6969
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0178 0.0151
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0315 0.4341
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Loa Loa (eye worm) hypothetical protein 0.0048 0.0344 0.0531
Leishmania major DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.1431 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Echinococcus granulosus expressed conserved protein 0.0089 0.0774 0.11
Brugia malayi beta-lactamase family protein 0.0152 0.1431 0.2209
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0056 0.008
Echinococcus granulosus aurora kinase A 0.0069 0.0562 0.0799
Brugia malayi Probable ClpP-like protease 0.0079 0.0664 0.1025
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.2384 0.3679
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0288 0.0359
Brugia malayi beta-lactamase 0.0152 0.1431 0.2209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0122 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0364
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0479 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.139 0.1975
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0152 0.1431 0.1408
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.1014 0.144
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0816
Giardia lamblia Kinase, PLK 0.0147 0.1372 1
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0562 0.3812
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.1014 0.1263
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0014 0.0022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.02 0.1932 0.2745
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0593 0.0916
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.002
Brugia malayi RNA binding protein 0.0072 0.0593 0.0916
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0047 0.0058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0124 0.056
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0124 0.1256
Schistosoma mansoni cpg binding protein 0.0029 0.0147 0.0209
Brugia malayi AF-10 protein 0.002 0.005 0.0076
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0267 0.0333
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1261 0.1791
Echinococcus granulosus dnaJ subfamily B 0.0395 0.3969 0.5638
Loa Loa (eye worm) hypothetical protein 0.0635 0.6479 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0288 0.1859
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.063 0.0895
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0178 0.0151
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0178 0.1076
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0178 0.1076
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0178 0.1076
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0047 0.0072
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0358 0.2247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.007
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0067 0.0329
Echinococcus granulosus tar DNA binding protein 0.0072 0.0593 0.0843
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0358 0.2356
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0056 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.139 0.1975
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0288 0.1742
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.139 0.2145
Mycobacterium tuberculosis Probable hydrolase 0.0152 0.1431 0.1408
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0178 0.0151
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.155 0.2201
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0178 0.1076
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0412
Schistosoma mansoni hypothetical protein 0.0112 0.1014 0.144
Schistosoma mansoni ferritin 0.0018 0.0027 0.0038
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0834 0.1185
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0593 0.0739
Onchocerca volvulus Alhambra homolog 0.0061 0.0479 0.3079
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0479 0.0681
Echinococcus granulosus beta LACTamase domain containing family member 0.0152 0.1431 0.2033
Echinococcus multilocularis muscleblind protein 0.0635 0.6479 0.8074
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0047 0.0072
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0178 0.1076
Echinococcus granulosus expressed protein 0.0018 0.0027 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0288 0.0409
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0288 0.1859
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0124 0.1528
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0047 0.0058
Mycobacterium ulcerans esterase/lipase LipP 0.0152 0.1431 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.0087
Echinococcus multilocularis smad 0.0017 0.0014 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0593 0.0843
Schistosoma mansoni hypothetical protein 0.002 0.005 0.007
Toxoplasma gondii aurora kinase 0.0069 0.0562 0.3724
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0178 0.1076
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0288 0.0409
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0056 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.1431 0.2033
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0047 0.0067
Schistosoma mansoni ferritin 0.0018 0.0027 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0149 0.0739
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0056 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 0.5
Mycobacterium tuberculosis Conserved protein 0.0152 0.1431 0.1408
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0149 0.0739
Schistosoma mansoni hypothetical protein 0.0061 0.0479 0.0681
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0562 0.3812
Trypanosoma cruzi polo-like protein kinase, putative 0.0147 0.1372 0.9572
Echinococcus multilocularis ferritin 0.0018 0.0027 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0056 0.0087
Schistosoma mansoni hypothetical protein 0.0689 0.704 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0178 0.0948
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0067 0.0146
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0288 0.1742
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.8025 1
Leishmania major cytochrome p450-like protein 0.0032 0.0178 0.0948
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0131 0.0202
Trypanosoma brucei unspecified product 0.003 0.0149 0.0739
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0288 0.1742
Loa Loa (eye worm) hypothetical protein 0.0043 0.0288 0.0445
Leishmania major cytochrome p450-like protein 0.0032 0.0178 0.0948
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0479 0.3125
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0288 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.0087
Brugia malayi Muscleblind-like protein 0.0635 0.6479 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0358 0.2356
Mycobacterium leprae conserved hypothetical protein 0.0152 0.1431 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.063 0.0895
Schistosoma mansoni ferritin light chain 0.0018 0.0027 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.1431 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0593 0.0843
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.0087
Echinococcus multilocularis dna polymerase eta 0.0043 0.0288 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.0562 0.2531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0479 0.0597
Echinococcus multilocularis muscleblind protein 1 0.0635 0.6479 0.8074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0056 0.008
Schistosoma mansoni hypothetical protein 0.0033 0.0185 0.0262
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 0.4537
Schistosoma mansoni hypothetical protein 0.0689 0.704 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0178 0.0151
Echinococcus multilocularis cpg binding protein 0.0029 0.0147 0.0183
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0664 0.0943
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0022
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0178 0.1076
Brugia malayi nuclear hormone receptor 0.0021 0.0056 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0816
Toxoplasma gondii ABC1 family protein 0.0152 0.1431 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0056 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.139 0.1975
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0056 0.0087
Schistosoma mansoni cpg binding protein 0.0028 0.0131 0.0186
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.038 0.0354
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0056 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0148 0.139 0.2146
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0178 0.0151
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0178 0.0253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0433 0.279
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0097 0.0364
Schistosoma mansoni hypothetical protein 0.0039 0.0252 0.0358
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0267 0.038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.1599 0.2271
Brugia malayi jmjC domain containing protein 0.002 0.0047 0.0072
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0178 0.1076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0014 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.139 0.1975
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0562 0.0868
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0562 0.2531
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0562 0.0799
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0315 0.0247
Loa Loa (eye worm) hypothetical protein 0.0105 0.0936 0.1444
Mycobacterium ulcerans lipase LipD 0.0152 0.1431 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.0087
Echinococcus granulosus peregrin 0.0065 0.0522 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0562 0.3812
Schistosoma mansoni coup transcription factor 0.0021 0.0056 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0056 0.007
Schistosoma mansoni hypothetical protein 0.0039 0.0252 0.0358
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0288 0.0262
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Onchocerca volvulus 0.0152 0.1431 1
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0456 0.2959
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0178 0.0151
Echinococcus multilocularis Smad4 0.0017 0.0014 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0288 0.1742
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0288 0.0409
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0315 0.0247
Echinococcus granulosus phd:f box containing protein 0.002 0.0047 0.0067
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0056 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0056 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0479 0.0681
Mycobacterium ulcerans beta-lactamase 0.0152 0.1431 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0056 0.008
Schistosoma mansoni phd/f-box containing protein 0.002 0.0047 0.0067
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0178 0.1076
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0178 0.1076
Loa Loa (eye worm) hypothetical protein 0.005 0.0363 0.0561
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0014 0.002
Entamoeba histolytica hypothetical protein 0.0112 0.1014 0.6695
Loa Loa (eye worm) hypothetical protein 0.0152 0.1431 0.2209
Brugia malayi serine/threonine protein kinase 6 0.0069 0.0562 0.0868
Mycobacterium tuberculosis Conserved protein 0.0152 0.1431 0.1408
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0178 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0056 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.0087
Toxoplasma gondii hypothetical protein 0.0027 0.0124 0.056
Onchocerca volvulus Serine\/threonine kinase homolog 0.0147 0.1372 0.9569
Echinococcus multilocularis geminin 0.0689 0.704 0.8772
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0288 0.1859
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Brugia malayi ecdysteroid receptor 0.0021 0.0056 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Entamoeba histolytica serine/threonine protein kinase, putative 0.0147 0.1372 1
Brugia malayi Cytochrome P450 family protein 0.0032 0.0178 0.0275
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0178 0.0948
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0358 0.2247
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0047 0.0072
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0178 0.0151
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.038 0.054
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0178 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0562 0.3812
Brugia malayi jmjC domain containing protein 0.002 0.0047 0.0072
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0456 0.2959
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 0.5
Brugia malayi Bromodomain containing protein 0.0065 0.0522 0.0806
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0178 0.1076
Schistosoma mansoni patched 1 0.0041 0.0267 0.038
Schistosoma mansoni hypothetical protein 0.0039 0.0252 0.0358
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1261 0.1571
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0097 0.0364
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0063 0.0079
Loa Loa (eye worm) Smad1 0.0017 0.0014 0.0022
Echinococcus multilocularis expressed conserved protein 0.0089 0.0774 0.0965
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.0562 0.8352
Mycobacterium tuberculosis Probable lipase LipE 0.0152 0.1431 0.1408
Schistosoma mansoni cpg binding protein 0.0029 0.0147 0.0209
Brugia malayi nuclear receptor NHR-88 0.0021 0.0056 0.0087
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0834 0.104
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0267 0.0412
Echinococcus granulosus dna polymerase eta 0.0043 0.0288 0.0409
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 0.4537
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Loa Loa (eye worm) acetyltransferase 0.0168 0.1599 0.2468
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.1431 1
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0138 0.0213
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0178 0.0948
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.038 0.2516
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.008
Schistosoma mansoni ferritin light chain 0.0018 0.0027 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.139 0.1732
Mycobacterium leprae putative cytochrome p450 0.0032 0.0178 0.1076
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0056 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0344 0.0531
Leishmania major cytochrome p450-like protein 0.0059 0.0456 0.2959
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0178 0.0151
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.0614 0.0765
Schistosoma mansoni protein phosphatase 2C 0.002 0.0047 0.0067
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.038 0.0354
Giardia lamblia Aurora kinase 0.0069 0.0562 0.2531
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0014 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0456 0.0704
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0056 0.007
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.063 0.0895
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0147 0.1372 0.9572
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0288 0.1742
Brugia malayi Cytochrome P450 family protein 0.0059 0.0456 0.0704
Brugia malayi hypothetical protein 0.0112 0.1014 0.1564
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.0562 0.0799
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0149 0.0739
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.034 0.3391 0.4225
Echinococcus granulosus jumonji domain containing protein 0.0085 0.0729 0.1036
Brugia malayi Cytochrome P450 family protein 0.0148 0.139 0.2146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.02 0.1932 0.2408
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1431 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0056 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0056 0.008
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0178 0.0948
Trypanosoma cruzi polo-like protein kinase, putative 0.0147 0.1372 0.9572
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Schistosoma mansoni apoferritin-2 0.0018 0.0027 0.0038
Mycobacterium tuberculosis Conserved protein 0.0152 0.1431 0.1408
Brugia malayi jmjC domain containing protein 0.0076 0.063 0.0973
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0344 0.0531
Schistosoma mansoni cytochrome P450 0.0032 0.0178 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.1431 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0178 0.1076
Onchocerca volvulus 0.0152 0.1431 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.0562 0.0701
Schistosoma mansoni ferritin 0.0018 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0014 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0056 0.0087
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0664 0.0943
Entamoeba histolytica hypothetical protein 0.0112 0.1014 0.6695
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0056 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0152 0.1431 0.1783
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Schistosoma mansoni DNA polymerase eta 0.0043 0.0288 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0056 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0056 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0072
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0664 0.4537
Entamoeba histolytica hypothetical protein 0.0112 0.1014 0.6695
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0178 0.0151
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0562 0.0868
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 1
Brugia malayi steroid hormone receptor 0.0021 0.0056 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0056 0.0087
Mycobacterium tuberculosis Probable esterase LipL 0.0152 0.1431 0.1408
Echinococcus multilocularis expressed protein 0.0018 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.1431 1
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0456 0.0704
Giardia lamblia PHD finger protein 15 0.0061 0.0479 0.1766
Schistosoma mansoni hypothetical protein 0.0395 0.3969 0.5638
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0056 0.0087
Schistosoma mansoni hypothetical protein 0.0039 0.0252 0.0358
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0152 0.1431 0.1408
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0056 0.008
Entamoeba histolytica protein kinase , putative 0.0069 0.0562 0.2531
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0178 0.0151
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.002
Schistosoma mansoni smad 0.0017 0.0014 0.002
Echinococcus granulosus cpg binding protein 0.0029 0.0147 0.0209
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0178 0.0151
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0664 1
Mycobacterium tuberculosis Probable lipase LipD 0.0152 0.1431 0.1408
Trypanosoma brucei aurora B kinase 0.0069 0.0562 0.3724
Plasmodium falciparum phd finger protein, putative 0.0061 0.0479 0.7009
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1372 0.1949
Brugia malayi hypothetical protein 0.0025 0.0097 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0087
Echinococcus granulosus dna polymerase kappa 0.0043 0.0288 0.0409
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0056 0.008
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.005 0.0019
Trypanosoma brucei unspecified product 0.003 0.0149 0.0739
Brugia malayi TAR-binding protein 0.0072 0.0593 0.0916
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0178 0.1076
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0593 0.0916
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0056 0.0087
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0288 0.0359
Leishmania major DNA polymerase eta, putative 0.0043 0.0288 0.1742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0288 0.1742
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0056 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0664 0.4458
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.005 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0178 0.0151
Brugia malayi beta-lactamase family protein 0.0152 0.1431 0.2209
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0056 0.008
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0456 0.3058
Mycobacterium leprae Probable lipase LipE 0.0152 0.1431 1
Echinococcus multilocularis jumonji domain containing protein 0.0085 0.0729 0.0909
Loa Loa (eye worm) RNA binding protein 0.0072 0.0593 0.0916
Brugia malayi jmjC domain containing protein 0.002 0.0047 0.0072
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0063 0.009
Echinococcus multilocularis peregrin 0.0065 0.0522 0.0651
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0358 0.0508
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.1599 0.2468
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0178 0.0151
Echinococcus multilocularis 0.0032 0.0178 0.0222
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0267 0.038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0056 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.1431 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0185 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0456 0.0647
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0056 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0288 0.1742
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0267 0.1711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.0087
Leishmania major hypothetical protein, conserved 0.0025 0.0097 0.0364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.1014 0.144
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1372 0.9578
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0056 0.008
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0358 0.2247
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0047 0.0067
Echinococcus multilocularis aurora kinase A 0.0069 0.0562 0.0701
Brugia malayi CHE-14 protein 0.0041 0.0267 0.0412
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0178 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0056 0.0087

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.27 ug ml-1 Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B method ChEMBL. 21664013
IC50 (binding) = 0.051 uM Inhibition of GST-tagged Aurora A kinase expressed in insect cells assessed as inhibition of [33P]gamma-ATP incorporation in substrate after 60 mins by scintillation counting ChEMBL. 21664013

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21664013

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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