Detailed information for compound 1151492

Basic information

Technical information
  • TDR Targets ID: 1151492
  • Name: (E)-2-methyl-3-[5-(pyridin-3-ylmethyl)thiophe n-2-yl]prop-2-enoic acid
  • MW: 259.324 | Formula: C14H13NO2S
  • H donors: 1 H acceptors: 3 LogP: 2.85 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C(=C/c1ccc(s1)Cc1cccnc1)/C
  • InChi: 1S/C14H13NO2S/c1-10(14(16)17)7-12-4-5-13(18-12)8-11-3-2-6-15-9-11/h2-7,9H,8H2,1H3,(H,16,17)/b10-7+
  • InChiKey: MQLCVRLQZNBDGI-JXMROGBWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-2-methyl-3-[5-(3-pyridylmethyl)-2-thienyl]prop-2-enoic acid
  • (E)-2-methyl-3-[5-(3-pyridylmethyl)-2-thienyl]acrylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0077 0.4052
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.018 0.2743
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.0026 0.0173
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0059
Schistosoma mansoni smad 0.0024 0.0032 0.0249
Leishmania major hypothetical protein, conserved 0.0032 0.0055 0.289
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0069 0.1052
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0065 0.0118
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0079 0.0782
Brugia malayi MH1 domain containing protein 0.0024 0.0032 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0191 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0065 0.0118
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0118
Loa Loa (eye worm) hypothetical protein 0.0499 0.1468 0.6691
Echinococcus multilocularis musashi 0.0027 0.004 0.0029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0069 0.1052
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0065 0.0118
Schistosoma mansoni ets-related 0.0221 0.0627 0.7068
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0069 0.04
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.2389
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0112 0.5865
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.018 0.3472
Leishmania major hypothetical protein, conserved 0.0035 0.0065 0.3398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0101 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0179 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0003 0.0045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0101 0.1033
Brugia malayi Latrophilin receptor protein 2 0.0129 0.0349 0.1589
Loa Loa (eye worm) hypothetical protein 0.0407 0.119 0.5424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.018 0.116
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0029 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0523 0.5874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Loa Loa (eye worm) hypothetical protein 0.032 0.0926 0.422
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0039 0.0077 0.404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Brugia malayi hypothetical protein 0.002 0.0018 0.0083
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.018 0.9357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus multilocularis geminin 0.017 0.0473 0.0463
Leishmania major importin beta-1 subunit, putative 0.0023 0.0029 0.1532
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.018 0.2743
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0039 0.0077 0.0067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.0518 0.0508
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.099
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0079 0.4126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0026 0.0117
Schistosoma mansoni lamin 0.0027 0.004 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.018 0.941
Echinococcus granulosus tar DNA binding protein 0.0191 0.0538 0.3619
Entamoeba histolytica protein kinase rad3, putative 0.0022 0.0026 0.0496
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0069 0.1052
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0538 0.6047
Brugia malayi Inositol-1 0.0073 0.018 0.0819
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0065 0.0296
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.1193
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0538 0.6047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Onchocerca volvulus 0.002 0.0018 0.0197
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0454 0.3043
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0069 0.0058
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0039 0.0077 0.1491
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0039 0.0077 0.404
Leishmania major phosphatidylinositol kinase related protein, putative 0.0039 0.0077 0.4052
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0182
Plasmodium falciparum importin beta, putative 0.0029 0.0046 0.1704
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.0349 0.2319
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0635 0.149
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0267 0.1216
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0359
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0191 1
Leishmania major GTP-binding protein, putative 0.0021 0.0023 0.1193
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0039 0.0077 0.404
Brugia malayi Bromodomain containing protein 0.008 0.02 0.091
Echinococcus granulosus lamin dm0 0.0027 0.004 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0538 0.6047
Onchocerca volvulus 0.023 0.0655 0.7076
Echinococcus granulosus geminin 0.017 0.0473 0.3174
Schistosoma mansoni Smad4 0.0024 0.0032 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0029 0.1532
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.099
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0729
Onchocerca volvulus 0.0027 0.004 0.0432
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0032 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0157 0.0223
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0112 0.5865
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0065 0.2805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0112 0.0102
Giardia lamblia GTOR 0.0039 0.0077 0.6379
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0069 0.1052
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0072
Trypanosoma brucei glucosidase, putative 0.0036 0.0069 0.3609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Echinococcus multilocularis Smad4 0.0024 0.0032 0.0022
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0046 0.0099 0.516
Mycobacterium ulcerans beta-lactamase 0.0035 0.0065 0.0118
Mycobacterium ulcerans lipase LipD 0.0035 0.0065 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0121 0.1851
Schistosoma mansoni lamin 0.0027 0.004 0.0338
Schistosoma mansoni survival motor neuron protein 0.0102 0.0267 0.2939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0112 0.1709
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0023 0.0401
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0157 0.0339
Loa Loa (eye worm) hypothetical protein 0.0064 0.0154 0.0702
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0032 0.0147
Echinococcus multilocularis snurportin 1 0.0305 0.0883 0.0873
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.0883 0.4024
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0154 0.0984
Leishmania major phosphatidylinositol 3-kinase, putative 0.0039 0.0077 0.404
Brugia malayi Ets-domain containing protein 0.0073 0.0179 0.0816
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0029 0.0446
Echinococcus multilocularis lamin dm0 0.0027 0.004 0.0029
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0191 1
Brugia malayi MH2 domain containing protein 0.0024 0.0032 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0065 0.0296
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0112 0.5865
Loa Loa (eye worm) hypothetical protein 0.0129 0.0349 0.1589
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.0349 0.1589
Echinococcus granulosus smad 0.0024 0.0032 0.0149
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0069 0.3035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0047 0.1773
Schistosoma mansoni importin beta-1 0.0029 0.0046 0.0402
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0065 0.0118
Echinococcus granulosus importin subunit beta 1 0.0029 0.0046 0.024
Schistosoma mansoni cellular tumor antigen P53 0.005 0.011 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0185 0.1195
Brugia malayi Doublecortin family protein 0.002 0.0018 0.0083
Schistosoma mansoni hypothetical protein 0.0129 0.0349 0.3876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0191 1
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0059
Schistosoma mansoni zinc finger protein 0.0041 0.0082 0.082
Echinococcus granulosus intermediate filament protein 0.0027 0.004 0.0202
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0191 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0112 0.5493
Brugia malayi RNA, U transporter 1 0.0081 0.0205 0.0935
Onchocerca volvulus 0.0027 0.004 0.0432
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.0538 0.2452
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.018 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0079 0.0468
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0016 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0185 0.0174
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0069 0.3609
Entamoeba histolytica hypothetical protein 0.0023 0.0029 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0571 0.2601
Loa Loa (eye worm) hypothetical protein 0.0147 0.0403 0.1838
Loa Loa (eye worm) beta-lactamase 0.0035 0.0065 0.0296
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0077 0.404
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.0349 0.2319
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0112 0.1709
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0018 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.3398
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0825
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.1034 0.4712
Echinococcus multilocularis serine protein kinase ATM 0.0054 0.0121 0.0111
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.1193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0623
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0112 0.0696
Echinococcus granulosus Smad4 0.0024 0.0032 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trichomonas vaginalis esterase, putative 0.0035 0.0065 0.099
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0039 0.0077 0.1491
Echinococcus granulosus zinc finger protein 0.0041 0.0082 0.0491
Onchocerca volvulus Huntingtin homolog 0.0134 0.0363 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Brugia malayi Ets-domain containing protein 0.0073 0.0179 0.0816
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.0518 0.3478
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.1193
Echinococcus granulosus lamin 0.0027 0.004 0.0202
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0104
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0077 0.0352
Onchocerca volvulus 0.002 0.0018 0.0197
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0023 0.0084
Entamoeba histolytica hypothetical protein 0.0054 0.0121 0.2343
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0072
Brugia malayi MH2 domain containing protein 0.0355 0.1034 0.4712
Trypanosoma brucei ISWI complex protein 0.0032 0.0055 0.289
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0063 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.099
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0112 0.0102
Trypanosoma brucei protein kinase, putative 0.0051 0.0112 0.5865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0047 0.0416
Plasmodium vivax importin-beta 2, putative 0.0029 0.0046 0.1704
Toxoplasma gondii FATC domain-containing protein 0.0054 0.0121 0.6021
Schistosoma mansoni hypothetical protein 0.0129 0.0349 0.3876
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0029 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0112 0.1163
Schistosoma mansoni rab6-interacting 0.002 0.0018 0.0088
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0077 0.404
Echinococcus granulosus serine protein kinase ATM 0.0054 0.0121 0.0759
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0118
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0739 0.2194 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0623
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0079 0.0068
Loa Loa (eye worm) hypothetical protein 0.0134 0.0363 0.1655
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0033 0.1743
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0112 0.5865
Onchocerca volvulus 0.005 0.011 0.1184
Schistosoma mansoni loxhd1 0.002 0.0018 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0077 0.0352
Entamoeba histolytica hypothetical protein 0.0185 0.0518 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0154 0.1644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0523 0.3515
Schistosoma mansoni rab6-interacting 0.002 0.0018 0.0088
Loa Loa (eye worm) hypothetical protein 0.0077 0.0191 0.087
Brugia malayi MH1 domain containing protein 0.0024 0.0032 0.0147
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0069 0.1332
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0018 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.018 0.941
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.0349 0.0338
Schistosoma mansoni hypothetical protein 0.0102 0.0267 0.2939
Schistosoma mansoni hypothetical protein 0.0034 0.0063 0.0602
Echinococcus multilocularis tar DNA binding protein 0.0191 0.0538 0.0528
Loa Loa (eye worm) hypothetical protein 0.0189 0.0532 0.2424
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0112 0.5865
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0039 0.0077 0.404
Mycobacterium ulcerans transcriptional regulator 0.1393 0.4174 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0101 0.0618
Brugia malayi latrophilin 2 splice variant baaae 0.0278 0.0801 0.3649
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.0523 0.2383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trichomonas vaginalis set domain proteins, putative 0.023 0.0655 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0077 0.3504
Brugia malayi TAR-binding protein 0.0191 0.0538 0.2452
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0079 0.1522
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0069 0.1052
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0079 0.0468
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0065 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.004 0.0182
Loa Loa (eye worm) hypothetical protein 0.0134 0.0363 0.1655
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0032 0.0149
Schistosoma mansoni bromodomain containing protein 0.0131 0.0357 0.3967
Schistosoma mansoni ran 0.0021 0.0023 0.014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0825
Trichomonas vaginalis ran, putative 0.0021 0.0023 0.0348
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.0026 0.0015
Echinococcus multilocularis lamin 0.0027 0.004 0.0029
Schistosoma mansoni ran 0.0021 0.0023 0.014
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0296
Entamoeba histolytica Ran family GTPase 0.0021 0.0023 0.044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0047 0.0416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.0349 0.0338
Brugia malayi hypothetical protein 0.005 0.0109 0.0496
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0523 0.0513
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.1468 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0065 0.2805
Schistosoma mansoni smad1 5 8 and 0.0024 0.0032 0.0249
Schistosoma mansoni polycystin 1-related 0.002 0.0018 0.0088
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.018 0.941
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0825
Loa Loa (eye worm) Smad1 0.0024 0.0032 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0523 0.5874
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0066 0.0638
Onchocerca volvulus 0.0102 0.0267 0.2882
Brugia malayi beta-lactamase 0.0035 0.0065 0.0296
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0025 0.0033 0.1
Loa Loa (eye worm) hypothetical protein 0.0278 0.0801 0.3649
Schistosoma mansoni smad1 5 8 and 0.0024 0.0032 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0083
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.0026 0.0104
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1393 0.4174 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0079 0.1203
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0018 0.0053
Brugia malayi follicle stimulating hormone receptor 0.0739 0.2194 1
Leishmania major hypothetical protein, conserved 0.0077 0.0191 1
Brugia malayi MH2 domain containing protein 0.0024 0.0032 0.0147
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0069 0.0314
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0065 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0065 0.3398
Brugia malayi hypothetical protein 0.032 0.0926 0.422
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0054 0.0121 0.6349
Entamoeba histolytica hypothetical protein 0.0185 0.0518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.1034 0.4712
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0039 0.0077 0.404
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0334 0.222
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.007 0.0319
Echinococcus multilocularis GPCR, family 2 0.0129 0.0349 0.0338
Brugia malayi Pre-SET motif family protein 0.0029 0.0047 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0523 0.0513
Schistosoma mansoni hypothetical protein 0.002 0.0018 0.0088
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0065 0.0118
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0179 0.1156
Brugia malayi intermediate filament protein 0.0027 0.004 0.0182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0825
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0039 0.0077 0.0763
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0077 0.404
Schistosoma mansoni hypothetical protein 0.0185 0.0518 0.5813
Onchocerca volvulus 0.032 0.0926 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0407 0.119 0.5424
Loa Loa (eye worm) hypothetical protein 0.0046 0.0099 0.0449
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.024
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0018 0.0143
Trypanosoma cruzi ISWI complex protein 0.0032 0.0055 0.289
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.018 0.0394
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0089 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0033 0.0508
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0022 0.0026 0.0496
Schistosoma mansoni alpha-glucosidase 0.0141 0.0385 0.4294
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0079 0.0068
Schistosoma mansoni inositol monophosphatase 0.0073 0.018 0.1939
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Brugia malayi MAP kinase sur-1 0.0051 0.0112 0.051
Brugia malayi hypothetical protein 0.002 0.0018 0.0083
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0023 0.0401
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0032 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0538 0.6047
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0063 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus granulosus snurportin 1 0.0305 0.0883 0.5984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Onchocerca volvulus 0.0095 0.0245 0.265
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0069 0.1052
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0454 0.0444
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.018 0.2743
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0032 0.0022
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0054 0.0121 0.6349
Loa Loa (eye worm) TAR-binding protein 0.0191 0.0538 0.2452
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0454 0.207
Loa Loa (eye worm) hypothetical protein 0.0089 0.0227 0.1035
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0066 0.0638
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0112 0.051
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0065 0.0118
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.0518 0.5813
Schistosoma mansoni alpha glucosidase 0.0036 0.0069 0.0669
Echinococcus multilocularis tumor protein p63 0.034 0.0988 0.0978
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0454 0.207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0039 0.0077 0.404
Onchocerca volvulus 0.0035 0.0065 0.0701
Echinococcus multilocularis neuropeptide s receptor 0.0499 0.1468 0.1459
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0066 0.0382
Entamoeba histolytica hypothetical protein 0.0185 0.0518 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0121 0.0553
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0454 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus granulosus GPCR family 2 0.0129 0.0349 0.2319
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0313 0.2075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0069 0.1332
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0191 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0079 0.0782
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0079 0.0068
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0179 0.0816
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0112 0.5865
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0112 0.1709
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0069 0.1052
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0016 0.0304
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.018 0.0169
Echinococcus multilocularis neuropeptide receptor A26 0.0499 0.1468 0.1459
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1393 0.4174 1
Schistosoma mansoni hypothetical protein 0.017 0.0473 0.5305
Schistosoma mansoni smad1 5 8 and 0.0024 0.0032 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0011 0.0161
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0104
Loa Loa (eye worm) intermediate filament protein 0.0027 0.004 0.0182
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0079 0.4126
Schistosoma mansoni zinc finger protein 0.0032 0.0055 0.0512
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0032 0.0147
Onchocerca volvulus 0.0035 0.0065 0.0701
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.004 0.0182
Loa Loa (eye worm) hypothetical protein 0.0062 0.0147 0.0671
Onchocerca volvulus 0.0029 0.0047 0.0506
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.018 0.941
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0069 0.0314
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0523 0.3515
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0189 0.0532 0.2424
Schistosoma mansoni inositol monophosphatase 0.0073 0.018 0.1939
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0154 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0069 0.1052
Schistosoma mansoni gabp alpha 0.0073 0.0179 0.1932
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0046 0.1704
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0079 0.4126
Trypanosoma cruzi ISWI complex protein 0.0032 0.0055 0.289
Echinococcus granulosus tumor protein p63 0.034 0.0988 0.6702
Loa Loa (eye worm) doublecortin family protein 0.002 0.0018 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0039 0.0077 0.404
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0313 0.0303
Onchocerca volvulus 0.0035 0.0065 0.0701
Brugia malayi RNA binding protein 0.0191 0.0538 0.2452
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.0516 0.7879
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0018 0.0053
Schistosoma mansoni intermediate filament proteins 0.0027 0.004 0.0338
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0112 0.0696
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0044 0.0227
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1393 0.4174 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0005
Schistosoma mansoni hypothetical protein 0.0305 0.0883 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0069 0.3609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Brugia malayi hypothetical protein 0.0499 0.1468 0.6691
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0079 0.0468
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0083
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0112 0.5865
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0039 0.0077 0.0763
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0039 0.0077 0.0067
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0079 0.4126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0026 0.0392
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0191 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.0523 0.2383
Schistosoma mansoni hypothetical protein 0.0043 0.0089 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Loa Loa (eye worm) inositol-1 0.0073 0.018 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0069 0.3609
Brugia malayi hypothetical protein 0.0185 0.0518 0.2359
Brugia malayi Pre-SET motif family protein 0.0202 0.0571 0.2601
Schistosoma mansoni lipoxygenase 0.0117 0.0313 0.3467
Brugia malayi PHD-finger family protein 0.0052 0.0116 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.3398
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0023 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0154 0.1644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Mycobacterium ulcerans hypothetical protein 0.0035 0.0065 0.0118
Loa Loa (eye worm) fli-1 protein 0.0221 0.0627 0.2858
Schistosoma mansoni hypothetical protein 0.0129 0.0349 0.3876
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.2389
Brugia malayi hypothetical protein 0.0077 0.0191 0.087
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0039 0.0077 0.0457
Echinococcus multilocularis zinc finger protein 0.0041 0.0082 0.0072
Brugia malayi Fli-1 protein 0.0221 0.0627 0.2858
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0077 0.0352
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0018 0.0008
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0112 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0077 0.0352
Schistosoma mansoni lipoxygenase 0.0082 0.0207 0.2246
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0054 0.0121 0.1269
Schistosoma mansoni hypothetical protein 0.017 0.0473 0.5305
Onchocerca volvulus Huntingtin homolog 0.0134 0.0363 0.3922
Brugia malayi Bromodomain containing protein 0.0156 0.043 0.1961
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0407 0.119 0.5424
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.1468 0.1459
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0026 0.1344
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0032 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0069 0.1052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0079 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0112 0.1709
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0065 0.0373
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0079 0.1203
Echinococcus granulosus neuropeptide s receptor 0.0499 0.1468 0.9997
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0033 0.0508
Entamoeba histolytica hypothetical protein 0.0185 0.0518 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0018 0.0143
Echinococcus multilocularis smad 0.0024 0.0032 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0191 0.0538 0.6047
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0066 0.0056
Mycobacterium ulcerans TetR family transcriptional regulator 0.1393 0.4174 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0077 0.404
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0039 0.0077 0.404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0296
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.099
Loa Loa (eye worm) hypothetical protein 0.0085 0.0215 0.098
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.0349 0.1589
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0117
Echinococcus granulosus neuropeptide receptor A26 0.0499 0.1468 0.9997
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0048
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.0538 0.2452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Brugia malayi Calcitonin receptor-like protein seb-1 0.0407 0.119 0.5424
Schistosoma mansoni hypothetical protein 0.0129 0.0349 0.3876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0077 0.1178
Echinococcus granulosus RUN 0.002 0.0018 0.0053
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0065 0.0054
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0296
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0039 0.0077 0.0457
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0077 0.404
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0208
Brugia malayi Importin beta-1 subunit 0.0029 0.0046 0.0208
Plasmodium vivax SET domain protein, putative 0.0029 0.0047 0.1773
Loa Loa (eye worm) hypothetical protein 0.005 0.011 0.05
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0079 0.1203
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0011
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0039 0.0077 0.404
Brugia malayi FAT domain containing protein 0.0017 0.0011 0.0048
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0523 0.5874
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0047 0.0036
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0046 0.0035
Schistosoma mansoni hypothetical protein 0.0032 0.0055 0.0512
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0018 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0079 0.6549
Echinococcus multilocularis RUN 0.002 0.0018 0.0008
Brugia malayi Smad1 0.0024 0.0032 0.0147
Schistosoma mansoni hypothetical protein 0.0278 0.0801 0.9058
Loa Loa (eye worm) RNA binding protein 0.0191 0.0538 0.2452
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0065 0.0118
Schistosoma mansoni alpha-glucosidase 0.0141 0.0385 0.4294
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0334 0.0324
Brugia malayi hypothetical protein 0.0134 0.0363 0.1655
Loa Loa (eye worm) hypothetical protein 0.008 0.02 0.0912

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.