Detailed information for compound 1181025

Basic information

Technical information
  • TDR Targets ID: 1181025
  • Name: (2E,4E,6Z,8E)-8-(3-ethyl-2-propan-2-yl-1-cycl ohex-2-enylidene)-3,7-dimethylocta-2,4,6-trie noic acid
  • MW: 314.462 | Formula: C21H30O2
  • H donors: 1 H acceptors: 2 LogP: 5.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1=C(C(C)C)/C(=C/C(=C\C=C\C(=C\C(=O)O)\C)/C)/CCC1
  • InChi: 1S/C21H30O2/c1-6-18-11-8-12-19(21(18)15(2)3)13-16(4)9-7-10-17(5)14-20(22)23/h7,9-10,13-15H,6,8,11-12H2,1-5H3,(H,22,23)/b10-7+,16-9-,17-14+,19-13+
  • InChiKey: OZUIXDDSOLQKNK-OPNVAXOVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E,4E,6Z,8E)-8-(3-ethyl-2-isopropyl-1-cyclohex-2-enylidene)-3,7-dimethyl-octa-2,4,6-trienoic acid
  • (2E,4E,6Z,8E)-8-(3-ethyl-2-isopropyl-1-cyclohex-2-enylidene)-3,7-dimethylocta-2,4,6-trienoic acid
  • (2E,4E,6Z,8E)-8-(3-ethyl-2-propan-2-yl-1-cyclohex-2-enylidene)-3,7-dimethyl-octa-2,4,6-trienoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus cellular retinoic acid binding protein II Starlite/ChEMBL References
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL References
Mus musculus retinoid X receptor alpha Starlite/ChEMBL References
Gallus gallus Cellular retinoic acid-binding protein I Starlite/ChEMBL References
Mus musculus retinoic acid receptor, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein Cellular retinoic acid-binding protein I   137 aa 133 aa 28.6 %
Echinococcus granulosus fatty acid binding protein FABP2 Cellular retinoic acid-binding protein I   137 aa 145 aa 31.7 %
Echinococcus multilocularis fatty acid binding protein FABP2 Cellular retinoic acid-binding protein I   137 aa 145 aa 31.7 %
Onchocerca volvulus Mannose-1-phosphate guanyltransferase alpha homolog Cellular retinoic acid-binding protein I   137 aa 123 aa 30.9 %
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein Cellular retinoic acid-binding protein I   137 aa 132 aa 32.6 %
Loa Loa (eye worm) embryonic fatty acid-binding protein Bm-FAB-1 Cellular retinoic acid-binding protein I   137 aa 139 aa 24.5 %
Brugia malayi ecdysteroid receptor retinoid X receptor alpha 439 aa 352 aa 23.9 %
Echinococcus granulosus fatty acids and retinol binding protein Cellular retinoic acid-binding protein I   137 aa 145 aa 33.8 %
Brugia malayi FAB1, identical Cellular retinoic acid-binding protein I   137 aa 139 aa 25.2 %
Onchocerca volvulus Cellular retinoic acid-binding protein I   137 aa 132 aa 28.8 %
Brugia malayi FAB1, identical cellular retinoic acid binding protein II 138 aa 139 aa 28.1 %
Echinococcus granulosus fatty acid binding protein FABP2 Cellular retinoic acid-binding protein I   137 aa 136 aa 37.5 %
Echinococcus multilocularis fatty acids and retinol binding protein Cellular retinoic acid-binding protein I   137 aa 145 aa 33.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus granulosus fatty acid binding protein FABP2 0.0083 0.0765 0.0881
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.0852 0.0985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0323 0.0143
Mycobacterium ulcerans hypothetical protein 0.0041 0.0286 0.0023
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0176 0.1816 0.212
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0083 0.0765 0.0853
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0079 0.0711 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0102 0.0979 0.2751
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0216 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0102 0.0979 0.2751
Onchocerca volvulus 0.003 0.0157 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0323 0.2483
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0323 0.0379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.0852 0.0985
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0102 0.0979 0.4541
Echinococcus granulosus g-protein coupled receptor 0.0091 0.0852 0.0985
Brugia malayi neuropeptide F receptor 0.0091 0.0852 0.0951
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0323 0.0258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.11 0.1294
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.0852 0.1002
Schistosoma mansoni cytochrome P450 0.0102 0.0979 0.1151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.024 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0037 0.024 0.0281
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.0852 0.0837
Brugia malayi RE15519p 0.0091 0.0852 0.0951
Brugia malayi Pepsin A precursor 0.0035 0.0216 0.0241
Echinococcus multilocularis fatty acid binding protein FABP2 0.0083 0.0765 0.0749
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.029 0.0324
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0507 0.1237
Onchocerca volvulus 0.0079 0.0711 0.0601
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0102 0.0979 0.2751
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0852 0.0837
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.024 0.0281
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Echinococcus multilocularis allatostatin A receptor 0.0091 0.0852 0.0837
Leishmania major hypothetical protein, conserved 0.0041 0.0286 0.2254
Toxoplasma gondii aspartyl protease 0.0035 0.0216 0.1186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0852 0.0837
Brugia malayi Serotonin receptor 0.0091 0.0852 0.0951
Schistosoma mansoni biogenic amine receptor 0.0091 0.0852 0.1002
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0852 0.0837
Onchocerca volvulus 0.0037 0.024 0.0094
Mycobacterium ulcerans lipase LipD 0.0041 0.0286 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0083 0.0765 0.0853
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0286 0.0441
Loa Loa (eye worm) CYP4Cod1 0.0112 0.1092 0.1218
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0852 0.1002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0079 0.0711 0.0835
Brugia malayi Cytochrome P450 family protein 0.0124 0.1225 0.1366
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.0852 0.0951
Brugia malayi Dopamine receptor protein 1 0.0091 0.0852 0.0951
Onchocerca volvulus 0.0091 0.0852 0.0754
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.0852 0.0985
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0852 0.0951
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0044 0.0323 0.0236
Toxoplasma gondii CMGC kinase, CK2 family 0.0079 0.0716 0.3942
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0852 0.0837
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0148 0.1496 0.176
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0237 0.0221
Brugia malayi glutathione reductase 0.0128 0.1271 0.1418
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.024 0.0263
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0286 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0168
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni RAR-like nuclear receptor 0.0079 0.0711 0.0835
Plasmodium falciparum plasmepsin I 0.0148 0.1496 0.8005
Loa Loa (eye worm) hypothetical protein 0.0176 0.1816 0.2025
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.0852 0.0754
Toxoplasma gondii cytochrome p450 superfamily protein 0.0102 0.0979 0.539
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0102 0.0979 0.4541
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0323 0.0258
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.1092 0.1218
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0852 0.0985
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0102 0.0979 0.4541
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0852 0.1002
Schistosoma mansoni opsin-like receptor 0.0091 0.0852 0.1002
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Echinococcus granulosus lamin dm0 0.003 0.0157 0.0165
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0852 0.0985
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0102 0.0979 0.2751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0079 0.0716 0.3128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0079 0.0711 0.0793
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0852 0.0985
Brugia malayi ORL1-like opioid receptor 0.0091 0.0852 0.0951
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0323 0.2537
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0079 0.0711 0.0835
Schistosoma mansoni opsin-like receptor 0.0091 0.0852 0.1002
Echinococcus multilocularis ecdysone induced protein 78C 0.0079 0.0711 0.0695
Onchocerca volvulus 0.003 0.0157 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0711 0.0818
Onchocerca volvulus 0.0091 0.0852 0.0754
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0323 0.0258
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.024 0.0281
Brugia malayi Dopamine receptor 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.2803 1
Schistosoma mansoni lamin 0.003 0.0157 0.0183
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0153 0.017
Trypanosoma cruzi casein kinase II, putative 0.0079 0.0716 0.5634
Onchocerca volvulus Huntingtin homolog 0.0138 0.1386 0.1329
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0102 0.0979 0.2751
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0711 0.0793
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0286 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Plasmodium falciparum glutathione reductase 0.0128 0.1271 0.6597
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0102 0.0979 0.2751
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.0852 0.0985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0246 0.0274
Plasmodium falciparum thioredoxin reductase 0.0128 0.1271 0.6597
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0286 0.027
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Echinococcus granulosus g protein coupled receptor 0.0091 0.0852 0.0985
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.024 0.0224
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0323 0.0666
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0102 0.0979 0.2751
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0079 0.0711 0.0793
Onchocerca volvulus 0.0091 0.0852 0.0754
Brugia malayi hypoxia-induced factor 1 0.0171 0.1758 0.1961
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Brugia malayi cytochrome P450 0.0102 0.0979 0.1092
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0641 0.0753
Leishmania major cytochrome p450-like protein 0.0102 0.0979 0.7701
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0148 0.1496 0.1744
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0079 0.0716 0.0799
Onchocerca volvulus 0.0037 0.024 0.0094
Onchocerca volvulus 0.0091 0.0852 0.0754
Loa Loa (eye worm) hypothetical protein 0.0055 0.0443 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0079 0.0711 0.0793
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0102 0.0979 0.2751
Onchocerca volvulus 0.0041 0.0286 0.0144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0852 0.0837
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0596 0.2043
Brugia malayi photoreceptor-specific nuclear receptor 0.0079 0.0711 0.0793
Echinococcus granulosus neuropeptide receptor 0.0562 0.6191 0.7277
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.024 0.0268
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0323 0.2537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0102 0.0979 0.4541
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0044 0.0323 0.0143
Schistosoma mansoni nuclear receptor 0.0037 0.024 0.0281
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis serotonin receptor 0.0091 0.0852 0.0837
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.0852 0.1002
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis thyroid hormone receptor alpha 0.0079 0.0711 0.0695
Brugia malayi ecdysteroid receptor 0.0079 0.0711 0.0793
Echinococcus granulosus cpg binding protein 0.0031 0.0172 0.0183
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0102 0.0979 0.7701
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0852 0.0985
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.0852 0.0985
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.0852 0.0837
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Onchocerca volvulus 0.0091 0.0852 0.0754
Schistosoma mansoni hypothetical protein 0.0091 0.0852 0.1002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0176 0.1816 1
Brugia malayi neuropeptide F receptor 0.0091 0.0852 0.0951
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.029 0.0341
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.024 0.0268
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0852 0.0837
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0061 0.0507 0.1443
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0852 0.0985
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.024 0.0224
Schistosoma mansoni hypothetical protein 0.0418 0.4565 0.5369
Plasmodium falciparum glutathione reductase 0.0044 0.0323 0.0666
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.0674 0.3199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0102 0.0979 0.4541
Echinococcus granulosus g protein coupled receptor 0.0091 0.0852 0.0985
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.029 0.0323
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0079 0.0711 0.0818
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0102 0.0979 0.2751
Brugia malayi nuclear receptor RXR 0.0042 0.029 0.0324
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.0852 0.0951
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Echinococcus granulosus serotonin receptor 0.0091 0.0852 0.0985
Plasmodium vivax plasmepsin IV, putative 0.0148 0.1496 0.8005
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni peptidase Clp (S14 family) 0.0176 0.1816 0.2135
Plasmodium falciparum plasmepsin II 0.0148 0.1496 0.8005
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.0852 0.0985
Schistosoma mansoni cpg binding protein 0.0031 0.0172 0.0201
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0176 0.1816 0.1802
Brugia malayi nuclear hormone receptor 0.0806 0.8964 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0061 0.0507 0.1821
Brugia malayi Steroid receptor seven-up type 2 0.0079 0.0711 0.0793
Brugia malayi nuclear receptor NHR-88 0.0079 0.0711 0.0793
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.0711 0.0835
Schistosoma mansoni single-minded 0.0055 0.0446 0.0524
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.11 0.1277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0711 0.0793
Brugia malayi RNA binding protein 0.0072 0.0641 0.0715
Onchocerca volvulus 0.0091 0.0852 0.0754
Brugia malayi hypothetical protein 0.0042 0.029 0.0324
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.11 0.1085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Echinococcus granulosus allatostatin A receptor 0.0091 0.0852 0.0985
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.0852 0.0951
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0852 0.1002
Toxoplasma gondii melibiase subfamily protein 0.0113 0.11 0.6058
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Echinococcus granulosus ecdysone induced protein 78C 0.0079 0.0711 0.0818
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.0852 0.1002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0079 0.0711 0.0818
Brugia malayi follicle stimulating hormone receptor 0.0091 0.0852 0.0951
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0711 0.0695
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0079 0.0711 0.0835
Onchocerca volvulus 0.0091 0.0852 0.0754
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0711 0.0793
Brugia malayi hypothetical protein 0.0042 0.029 0.0324
Schistosoma mansoni intermediate filament proteins 0.003 0.0157 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0102 0.0979 0.7701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Schistosoma mansoni neuropeptide receptor 0.0562 0.6191 0.7282
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.0852 0.0951
Schistosoma mansoni fatty acid binding protein 0.0083 0.0765 0.0899
Brugia malayi hypothetical protein 0.0138 0.1386 0.1547
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0596 0.0683
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.11 0.1085
Toxoplasma gondii hypothetical protein 0.0061 0.0507 0.2791
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0852 0.0837
Brugia malayi larval opioid receptor 0.0091 0.0852 0.0951
Brugia malayi Nuclear hormone receptor E75 0.0037 0.024 0.0268
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0765 0.8501 0.8499
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0596 0.07
Brugia malayi sulfakinin receptor protein 0.0091 0.0852 0.0951
Brugia malayi AKH receptor 0.0091 0.0852 0.0951
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0042 0.029 0.0324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.029 0.0324
Echinococcus granulosus tar DNA binding protein 0.0072 0.0641 0.0736
Loa Loa (eye worm) glutathione reductase 0.0128 0.1271 0.1418
Onchocerca volvulus 0.0091 0.0852 0.0754
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Loa Loa (eye worm) hypothetical protein 0.0042 0.029 0.0324
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.024 0.0263
Brugia malayi nuclear receptor NHR-67 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni amine GPCR 0.0091 0.0852 0.1002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0641 0.0715
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0102 0.0979 0.4541
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0237 0.0259
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.024 0.0263
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0716 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0323 0.2483
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.024 0.0224
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0102 0.0979 0.2751
Schistosoma mansoni nuclear receptor 0.0037 0.024 0.0281
Loa Loa (eye worm) hypothetical protein 0.0148 0.1496 0.1669
Schistosoma mansoni hypothetical protein 0.0091 0.0852 0.1002
Brugia malayi CXXC zinc finger family protein 0.0029 0.0153 0.017
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Plasmodium vivax aspartyl proteinase, putative 0.0148 0.1496 0.8005
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0148 0.1496 0.1669
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.024 0.0224
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0102 0.0979 0.4541
Loa Loa (eye worm) hypothetical protein 0.0042 0.029 0.0324
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Leishmania major cytochrome p450-like protein 0.0112 0.1092 0.8588
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0711 0.0793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0102 0.0979 0.2751
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0079 0.0711 0.0818
Echinococcus granulosus thioredoxin glutathione reductase 0.0128 0.1271 0.1479
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0102 0.0979 0.2751
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.0852 0.0985
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.029 0.0274
Schistosoma mansoni hypothetical protein 0.0037 0.0237 0.0278
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0852 0.1002
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0852 0.0985
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.11 0.1294
Echinococcus multilocularis cpg binding protein 0.0031 0.0172 0.0155
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4565 0.536
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0852 0.1002
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Onchocerca volvulus 0.0091 0.0852 0.0754
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Schistosoma mansoni amine GPCR 0.0091 0.0852 0.1002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0674 0.0792
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0596 0.328
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0852 0.0951
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Echinococcus multilocularis lamin dm0 0.003 0.0157 0.014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0157 0.0175
Schistosoma mansoni amine GPCR 0.0091 0.0852 0.1002
Plasmodium falciparum thioredoxin reductase 0.0044 0.0323 0.0666
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0079 0.0711 0.0835
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0079 0.0711 0.0695
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Schistosoma mansoni histamine h1 receptor 0.0091 0.0852 0.1002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0852 0.1002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.024 0.0268
Entamoeba histolytica casein kinase, putative 0.0079 0.0716 1
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4565 0.4556
Trypanosoma brucei Casein kinase II 0.0079 0.0716 0.5603
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.0852 0.1002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.0852 0.1002
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.0852 0.0837
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0711 0.0835
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Brugia malayi Cytochrome P450 family protein 0.0112 0.1092 0.1218
Schistosoma mansoni hypothetical protein 0.0091 0.0852 0.1002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0596 0.058
Schistosoma mansoni hypothetical protein 0.0038 0.0246 0.0288
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.024 0.0263
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.0852 0.0837
Loa Loa (eye worm) beta-lactamase 0.0041 0.0286 0.0319
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0112 0.1092 0.1218
Brugia malayi steroid hormone receptor 0.0079 0.0711 0.0793
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0102 0.0979 0.4541
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0286 0.2254
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0102 0.0979 0.2751
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0079 0.0711 0.0793
Onchocerca volvulus 0.0035 0.0216 0.0068
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0323 0.1773
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.0852 0.1002
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0152 0.1545 0.1723
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0102 0.0979 0.2751
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Mycobacterium leprae Conserved hypothetical protein 0.0102 0.0979 0.4528
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0852 0.0951
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0596 0.2043
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0102 0.0979 0.4541
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Toxoplasma gondii ABC1 family protein 0.0041 0.0286 0.1574
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.0852 0.1002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0091 0.0852 0.0951
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0443 0.0494
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0323 0.2537
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0216 0.1186
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.0852 0.0837
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0596 0.07
Brugia malayi beta-lactamase family protein 0.0041 0.0286 0.0319
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0115 0.1128 0.3343
Onchocerca volvulus Bile acid receptor homolog 0.0079 0.0711 0.0601
Brugia malayi conserved hypotetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0102 0.0979 0.2751
Brugia malayi G-protein coupled receptor 0.0091 0.0852 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0079 0.0711 0.0793
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0323 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0079 0.0711 0.0793
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0079 0.0711 0.0835
Brugia malayi G-protein coupled receptor 0.0091 0.0852 0.0951
Brugia malayi beta-lactamase 0.0041 0.0286 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Brugia malayi Serotonin receptor 0.0091 0.0852 0.0951
Trypanosoma brucei cytochrome P450, putative 0.0112 0.1092 0.8578
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0596 0.123
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) intermediate filament protein 0.003 0.0157 0.0175
Brugia malayi Melibiase family protein 0.0075 0.0674 0.0751
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0102 0.0979 0.2751
Mycobacterium ulcerans beta-lactamase 0.0041 0.0286 0.0023
Echinococcus multilocularis G protein coupled receptor 139 0.0562 0.6191 0.6184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0711 0.0793
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0852 0.0837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Leishmania major casein kinase II, putative 0.0079 0.0716 0.5634
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0189 0.0211
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0852 0.1002
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0246 0.0274
Echinococcus granulosus neuropeptide receptor 0.0091 0.0852 0.0985
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0711 0.0695
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0079 0.0711 0.0793
Loa Loa (eye worm) DR-78 0.0037 0.024 0.0268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0079 0.0711 0.0793
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0128 0.1271 0.3913
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0765 0.8501 0.9484
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.0852 0.0951
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.0852 0.0837
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0079 0.0711 0.0793
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0102 0.0979 0.2751
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0641 0.0753
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0079 0.0711 0.0695
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.0852 0.0754
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0852 0.0837
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0852 0.0837
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Schistosoma mansoni amine GPCR 0.0091 0.0852 0.1002
Brugia malayi TAR-binding protein 0.0072 0.0641 0.0715
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0323 0.2537
Brugia malayi Cytochrome P450 family protein 0.0102 0.0979 0.1092
Plasmodium falciparum plasmepsin IV 0.0148 0.1496 0.8005
Toxoplasma gondii aspartyl protease ASP1 0.0148 0.1496 0.8241
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0102 0.0979 0.4541
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0852 0.1002
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.0852 0.1002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.0852 0.0837
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0216 0.0241
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0176 0.1816 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0124 0.1225 0.1366
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0189 0.0211
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.024 0.0268
Loa Loa (eye worm) cytochrome P450 0.0102 0.0979 0.1092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0115 0.1128 0.5502
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0079 0.0711 0.0793
Echinococcus granulosus cytochrome P450 2K1 0.0102 0.0979 0.1134
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0852 0.0985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Trypanosoma cruzi trypanothione reductase, putative 0.0128 0.1271 1
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0019
Brugia malayi Dopamine receptor protein 2 0.0091 0.0852 0.0951
Echinococcus multilocularis neuropeptide receptor 0.0562 0.6191 0.6184
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0852 0.0985
Trypanosoma brucei trypanothione reductase 0.0128 0.1271 1
Schistosoma mansoni hypothetical protein 0.0381 0.4145 0.4875
Plasmodium vivax thioredoxin reductase, putative 0.0128 0.1271 0.6597
Brugia malayi Melatonin receptor type 1A 0.0091 0.0852 0.0951
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0102 0.0979 0.4541
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.0852 0.0837
Schistosoma mansoni zinc finger protein 0.0037 0.024 0.0281
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0102 0.0979 0.4541
Onchocerca volvulus 0.0041 0.0286 0.0144
Onchocerca volvulus 0.0091 0.0852 0.0754
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.024 0.0224
Echinococcus granulosus lamin 0.003 0.0157 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0641 0.0753
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0112 0.1092 0.5277
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0323 0.036
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0286 0.0336
Toxoplasma gondii thioredoxin reductase 0.0128 0.1271 0.7
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis musashi 0.003 0.0157 0.014
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0216 0.0241
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Schistosoma mansoni hypothetical protein 0.0091 0.0852 0.1002
Echinococcus granulosus single minded 2 0.0056 0.0455 0.0517
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0102 0.0979 0.2751
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.0852 0.0951
Schistosoma mansoni opsin-like receptor 0.0091 0.0852 0.1002
Echinococcus granulosus hypothetical protein 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0286 0.2254
Loa Loa (eye worm) thioredoxin reductase 0.0128 0.1271 0.1418
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.024 0.0263
Brugia malayi hypothetical protein 0.0185 0.1921 0.2143
Brugia malayi beta-lactamase family protein 0.0041 0.0286 0.0319
Echinococcus granulosus sex peptide receptor 0.0091 0.0852 0.0985
Echinococcus granulosus fmrfamide receptor 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0042 0.029 0.0324
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0286 0.2197
Leishmania major cytochrome p450-like protein 0.0102 0.0979 0.7701
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0641 0.0715
Brugia malayi nuclear hormone receptor 0.0079 0.0711 0.0793
Onchocerca volvulus 0.0091 0.0852 0.0754
Brugia malayi tailless protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Schistosoma mansoni cpg binding protein 0.0029 0.0153 0.0179
Brugia malayi Casein kinase II, alpha chain 0.0079 0.0716 0.0799
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0596 0.2043
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.024 0.0281
Schistosoma mansoni cathepsin D (A01 family) 0.0436 0.4764 0.5604
Schistosoma mansoni coup transcription factor 0.0079 0.0711 0.0835
Schistosoma mansoni neuropeptide receptor 0.0091 0.0852 0.1002
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0042 0.029 0.0324
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0102 0.0979 0.7684
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.0852 0.0985
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.0852 0.0837
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0711 0.0818
Echinococcus multilocularis peptidase Clp (S14 family) 0.0115 0.1128 0.1113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.0852 0.0951
Onchocerca volvulus 0.0091 0.0852 0.0754
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0102 0.0979 0.2751
Echinococcus granulosus neuropeptide s receptor 0.0091 0.0852 0.0985
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0323 0.0306
Schistosoma mansoni cpg binding protein 0.0031 0.0172 0.0201
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0017 0.0019
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0148 0.1496 0.8241
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0017 0.0019
Schistosoma mansoni amine GPCR 0.0091 0.0852 0.1002
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0283 0.0267
Echinococcus multilocularis lamin 0.003 0.0157 0.014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0079 0.0711 0.0695
Schistosoma mansoni nuclear hormone receptor 0.0037 0.024 0.0281
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0323 0.1773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0079 0.0711 0.0793
Brugia malayi hypothetical protein 0.0037 0.024 0.0268
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0079 0.0716 0.3128
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0216 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Brugia malayi nuclear receptor RXR 0.0037 0.024 0.0268
Echinococcus multilocularis somatostatin receptor 0.0091 0.0852 0.0837
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0148 0.1496 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0102 0.0979 0.4541
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.0852 0.0837
Echinococcus granulosus fatty acid binding protein FABP2 0.0083 0.0765 0.0881
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0323 0.0666
Echinococcus granulosus intermediate filament protein 0.003 0.0157 0.0165
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0286 0.0336
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0102 0.0979 0.4541
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0323 0.2537
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0765 0.8501 1
Loa Loa (eye worm) hypothetical protein 0.0769 0.8544 0.9531
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.0852 0.0951
Onchocerca volvulus Protein ultraspiracle homolog 0.0079 0.0711 0.0601
Echinococcus multilocularis casein kinase ii subunit alpha 0.0079 0.0716 0.0701
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0852 0.0837
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.029 0.0324
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.0852 0.0837
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0641 0.0626
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0079 0.0711 0.0695
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Mycobacterium tuberculosis Probable oxidoreductase 0.0044 0.0323 0.0143
Schistosoma mansoni biogenic amine receptor 0.0091 0.0852 0.1002
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0148 0.1496 0.1482
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.0852 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0711 0.0793
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Brugia malayi Cytochrome P450 family protein 0.0112 0.1092 0.1218
Loa Loa (eye worm) steroid hormone receptor 0.0079 0.0711 0.0793
Loa Loa (eye worm) hypothetical protein 0.0138 0.1386 0.1547
Echinococcus granulosus g protein coupled receptor 0.0091 0.0852 0.0985
Echinococcus granulosus geminin 0.0381 0.4145 0.4866
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0102 0.0979 0.4541
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.024 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0323 0.2483
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis geminin 0.0381 0.4145 0.4135
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0323 0.036
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0852 0.0837
Schistosoma mansoni biogenic amine receptor 0.0091 0.0852 0.1002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni neuropeptide receptor 0.0091 0.0852 0.1002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Schistosoma mansoni lamin 0.003 0.0157 0.0183
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.0852 0.0837
Brugia malayi nuclear receptor NHR-88 0.0037 0.024 0.0268
Echinococcus multilocularis orexin receptor type 2 0.0091 0.0852 0.0837
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0641 0.0753
Brugia malayi ecdysone receptor 0.0037 0.024 0.0268
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0061 0.0507 0.1821
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0526 0.0618
Brugia malayi hypothetical protein 0.0035 0.0216 0.0241
Brugia malayi hypothetical protein 0.0035 0.0216 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0079 0.0711 0.0695
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0443 0.0494
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0674 0.0792
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0641 0.0715
Onchocerca volvulus 0.0091 0.0852 0.0754
Schistosoma mansoni adenoreceptor 0.0091 0.0852 0.1002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0237 0.0278
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0852 0.0837
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.0852 0.1002
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0283 0.0316
Loa Loa (eye worm) hypothetical protein 0.0138 0.1386 0.1547
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0852 0.1002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0323 0.2483
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0323 0.0666
Loa Loa (eye worm) hypothetical protein 0.0075 0.0674 0.0751
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0102 0.0979 0.4541
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0115 0.1128 0.3343
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.11 0.1294
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0102 0.0979 0.4541
Brugia malayi Probable ClpP-like protease 0.0176 0.1816 0.2025
Echinococcus multilocularis fatty acid binding protein FABP2 0.0083 0.0765 0.0749
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0852 0.0837
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0176 0.1816 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0446 0.0524
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0079 0.0711 0.0793
Plasmodium vivax unspecified product 0.0079 0.0716 0.3128
Onchocerca volvulus 0.0091 0.0852 0.0754
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.024 0.0094
Brugia malayi hypothetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis sex peptide receptor 0.0091 0.0852 0.0837
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0852 0.0985
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0475 0.5211 0.6123
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Brugia malayi GnHR receptor homolog 0.0091 0.0852 0.0951
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0641 0.0753
Brugia malayi hypothetical protein 0.0037 0.0237 0.0264
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.0852 0.0985
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.0852 0.1002
Plasmodium falciparum plasmepsin VI 0.0148 0.1496 0.8005
Onchocerca volvulus 0.0041 0.0283 0.014
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0806 0.8964 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0319
Leishmania major trypanothione reductase 0.0128 0.1271 1
Schistosoma mansoni protein kinase 0.0079 0.0716 0.0842
Schistosoma mansoni fatty acid binding protein 0.0083 0.0765 0.0899
Brugia malayi PAS domain containing protein 0.0055 0.0446 0.0497
Trypanosoma cruzi cytochrome P450, putative 0.0112 0.1092 0.8588
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0102 0.0979 0.4541
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.0852 0.0951
Onchocerca volvulus 0.0091 0.0852 0.0754
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Brugia malayi G protein-coupled receptor 0.0091 0.0852 0.0951
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.029 0.0341
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0216 0.0253
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0711 0.0835
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0102 0.0979 0.4541
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0434 0.4741 0.4732
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypoxia-induced factor 1 0.0171 0.1758 0.1961
Schistosoma mansoni retinoic acid receptor RXR 0.0475 0.5211 0.613
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0079 0.0711 0.0793
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0711 0.0793
Brugia malayi intermediate filament protein 0.003 0.0157 0.0175
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0216 0.0241
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Plasmodium vivax glutathione reductase, putative 0.0128 0.1271 0.6597
Onchocerca volvulus 0.0091 0.0852 0.0754
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0102 0.0979 0.2751
Onchocerca volvulus Huntingtin homolog 0.0138 0.1386 0.1329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0017 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.0852 0.0985
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0852 0.0837
Echinococcus granulosus FTZ F1 alpha 0.0079 0.0711 0.0818
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0102 0.0979 0.4541
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0852 0.0951
Loa Loa (eye worm) RNA binding protein 0.0072 0.0641 0.0715
Echinococcus multilocularis 0.0102 0.0979 0.0964
Loa Loa (eye worm) hypothetical protein 0.0037 0.024 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0323 0.2537
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0852 0.0837
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0852 0.0985
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0176 0.1816 1
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0716 0.3552
Trypanosoma cruzi cytochrome P450, putative 0.0112 0.1092 0.8588
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0176 0.1816 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0102 0.0979 0.7701
Schistosoma mansoni neuropeptide receptor 0.0091 0.0852 0.1002
Brugia malayi hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0079 0.0711 0.0793
Onchocerca volvulus 0.0041 0.0286 0.0144
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.11 0.1294
Schistosoma mansoni cathepsin D (A01 family) 0.0436 0.4764 0.5604
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0765 0.8501 1
Echinococcus granulosus peptidase Clp S14 family 0.0115 0.1128 0.131
Brugia malayi Thioredoxin reductase 0.0128 0.1271 0.1418
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0323 0.0666
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Mycobacterium leprae putative cytochrome p450 0.0102 0.0979 0.4528
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0323 0.0298
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0711 0.0835
Schistosoma mansoni hypothetical protein 0.0381 0.4145 0.4875
Onchocerca volvulus 0.0091 0.0852 0.0754
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0102 0.0979 0.7701
Echinococcus multilocularis serotonin receptor 0.0091 0.0852 0.0837
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0216 0.1186
Echinococcus granulosus orexin receptor type 2 0.0091 0.0852 0.0985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0852 0.0837
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0157 0.0175
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0443 0.0494
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0848 0.9435 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0128 0.1271 0.1257
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0079 0.0711 0.0835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0852 0.1002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.0852 0.0837
Brugia malayi Nuclear hormone receptor E75 0.0037 0.024 0.0268
Onchocerca volvulus 0.0152 0.1545 0.15
Schistosoma mansoni myosin xvIII 0.0091 0.0852 0.1002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0451 0.2479
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0286 0.0319
Loa Loa (eye worm) hypothetical protein 0.0765 0.8501 0.9484
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0852 0.0985
Schistosoma mansoni hypothetical protein 0.0017 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0596 0.4689
Onchocerca volvulus 0.0035 0.0216 0.0068
Loa Loa (eye worm) hypothetical protein 0.0185 0.1921 0.2143
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0286 0.0319
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0286 0.0318
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.0852 0.0837
Echinococcus granulosus casein kinase ii subunit alpha 0.0079 0.0716 0.0825
Loa Loa (eye worm) hypothetical protein 0.0079 0.0711 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.024 0.0263
Schistosoma mansoni hypothetical protein 0.0102 0.0979 0.1151
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0044 0.0323 0.0143
Echinococcus granulosus somatostatin receptor 0.0091 0.0852 0.0985
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.0852 0.0951
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0216 0.0253
Loa Loa (eye worm) hypothetical protein 0.0091 0.0852 0.0951
Giardia lamblia Kinase, CMGC CK2 0.0079 0.0716 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.0852 0.1002

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 43 nM Antitumour activity in Mouse Skin Papilloma model ChEMBL. 8809153
IC50 (binding) > 1000 nM Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha ChEMBL. 8809153
IC50 (binding) = 1000 nM Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha ChEMBL. 8809153
IC50 (binding) > 10 uM Inhibition of [3H]-ATRA binding to chick skin Cytoplasmic retinoic acid binding protein ChEMBL. 8809153
Inhibition (binding) = 15 % Inhibition of chick skin Cytoplasmic retinoic acid binding protein at 100-fold excess ligand ChEMBL. 8809153
Inhibition (binding) = 42 % Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RAR alpha ChEMBL. 8809153
Inhibition (binding) = 50 % Percent inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alpha ChEMBL. 8809153
Kd (binding) = 16 nM Inhibition of binding to human Retinoic acid receptor RXR DEF domain ChEMBL. 8809153
Kd (binding) > 200 nM Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1 ChEMBL. 8809153
Kd (binding) > 200 nM Inhibition of [3H]-ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 2 ChEMBL. 8809153
Reduction (functional) > 100 % Percentage papilloma reduction (81) at 45.9 nmol dose 1 hr prior to TPA ChEMBL. 8809153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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