Detailed information for compound 1184272

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.391 | Formula: C19H23NO2
  • H donors: 1 H acceptors: 0 LogP: 3.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC[C@]1(OC)Cc2c([C@@H]1Oc1ccccc1C)cccc2
  • InChi: 1S/C19H23NO2/c1-14-8-4-7-11-17(14)22-18-16-10-6-5-9-15(16)12-19(18,21-3)13-20-2/h4-11,18,20H,12-13H2,1-3H3/t18-,19+/m0/s1
  • InChiKey: IFOBTLHRUXGTFC-RBUKOAKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0166 0.0256
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0057 0.0337 0.0536
Echinococcus granulosus tumor protein p63 0.0327 0.3931 0.456
Schistosoma mansoni protein kinase 0.0231 0.2649 0.3116
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0035 0.0044 0.0034
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0157 0.1674 0.2791
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni heat shock protein 0.0445 0.5488 0.6479
Trypanosoma brucei cdc2-related kinase 3 0.0061 0.0389 0.0665
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0121 0.1188 0.2128
Echinococcus granulosus casein kinase ii subunit beta 0.0043 0.0155 0.0159
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0244 0.0267
Trichomonas vaginalis heat shock protein, putative 0.0348 0.4204 0.7653
Entamoeba histolytica protein kinase, putative 0.0129 0.1301 0.2371
Schistosoma mansoni nck2/grb4 0.0042 0.0141 0.0146
Trichomonas vaginalis cyclins, putative 0.0037 0.0082 0.0116
Giardia lamblia Kinase, CMGC GSK 0.0066 0.0465 0.0804
Echinococcus granulosus protein kinase 0.0033 0.0026 0.0009
Entamoeba histolytica receptor protein kinase, putative 0.0033 0.0026 0.0047
Chlamydia trachomatis DNA gyrase subunit B 0.0097 0.087 0.2333
Loa Loa (eye worm) TK/INSR protein kinase 0.0392 0.4787 0.8036
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0082 0.0107
Trypanosoma cruzi casein kinase II, putative 0.0089 0.0763 0.135
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.0399
Echinococcus multilocularis tyrosine protein kinase shark 0.0556 0.696 0.6954
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0072 0.0537 0.0615
Schistosoma mansoni kinase 0.0066 0.0467 0.0531
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0033 0.0026 0.0013
Brugia malayi kinase, mitochondrial precursor 0.0228 0.2615 0.4376
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0075 0.0581 0.0667
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0037 0.0082 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0106 0.0994 0.0978
Loa Loa (eye worm) hypothetical protein 0.0037 0.0082 0.0107
Brugia malayi serine/threonine-protein kinase 6 0.0142 0.1464 0.2436
Echinococcus multilocularis hypothetical protein 0.0047 0.0215 0.0197
Loa Loa (eye worm) hypothetical protein 0.0226 0.259 0.4333
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0252 0.2927 0.4901
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0049 0.0232 0.0378
Entamoeba histolytica hypothetical protein 0.0033 0.0028 0.005
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0094 0.0839 0.1634
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0049 0.0232 0.0378
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0026 0.0007
Leishmania major cyclin 0.0037 0.0082 0.0103
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0035 0.0044 0.0026
Echinococcus multilocularis FL cytokine receptor 0.0033 0.0026 0.0007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Plasmodium falciparum protein kinase, putative 0.0044 0.0166 0.0256
Brugia malayi integrin-linked kinase 0.0033 0.0026 0.0013
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0142 0.1464 0.2667
Trichomonas vaginalis endoplasmin, putative 0.0276 0.3246 0.5901
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Brugia malayi Protein kinase domain containing protein 0.0059 0.0365 0.0584
Echinococcus multilocularis epidermal growth factor receptor 0.0263 0.3074 0.3062
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0097 0.087 0.1578
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0037 0.0076 0.0092
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Brugia malayi Protein kinase domain containing protein 0.0077 0.0603 0.0986
Schistosoma mansoni serine/threonine protein kinase 0.004 0.012 0.012
Trypanosoma cruzi Protein kinase B 0.0037 0.0076 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.1371 0.2474
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Trypanosoma cruzi cyclin 6, putative 0.0037 0.0082 0.0103
Schistosoma mansoni tyrosine kinase 0.0392 0.4787 0.5649
Echinococcus granulosus c src tyrosine kinase 0.0075 0.0581 0.0656
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0033 0.0026 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Trypanosoma cruzi cdc2-related kinase 1 0.0061 0.0389 0.0665
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0465 0.0847
Onchocerca volvulus 0.0059 0.0365 0.0684
Loa Loa (eye worm) TK/EPH protein kinase 0.0033 0.0026 0.0013
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.038
Plasmodium vivax DNA gyrase subunit B, putative 0.0097 0.087 0.1545
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0365 0.0347
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.2194 0.2577
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0581 0.0656
Trypanosoma brucei Casein kinase II 0.0089 0.0763 0.135
Echinococcus multilocularis eukaryotic elongation factor 2 kinase 0.0037 0.0078 0.006
Brugia malayi Furin-like cysteine rich region family protein 0.0344 0.4146 0.6956
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0075 0.0581 0.0564
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.038
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0097 0.087 0.1578
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0097 0.087 0.077
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0075 0.0581 0.0656
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0033 0.0026 0.0009
Plasmodium falciparum casein kinase 2, alpha subunit 0.0089 0.0763 0.135
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.0399
Loa Loa (eye worm) AGC/AKT protein kinase 0.0059 0.0368 0.059
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0192 0.0292
Giardia lamblia Kinase, CMGC CDK 0.0061 0.0389 0.0665
Onchocerca volvulus Serine\/threonine kinase homolog 0.0121 0.1188 0.2334
Loa Loa (eye worm) haspin protein kinase 0.008 0.0646 0.1059
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis tyrosine protein kinase csk 0.0033 0.0026 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0075 0.0136
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0244 0.0267
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0049 0.0232 0.0378
Echinococcus multilocularis activin receptor type 0.0044 0.0166 0.0148
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Onchocerca volvulus Tyrosine kinase homolog 0.0409 0.5014 1
Trichomonas vaginalis heat shock protein, putative 0.0179 0.1962 0.3554
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0066 0.0465 0.0804
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Trichomonas vaginalis cyclin B, putative 0.0037 0.0082 0.0116
Echinococcus granulosus Immunoglobulin 0.0072 0.0537 0.0605
Onchocerca volvulus 0.0077 0.0603 0.1162
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0033 0.0026 0.0007
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0244 0.0226
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0149 0.1557 0.1541
Loa Loa (eye worm) PEK/PEK protein kinase 0.0231 0.2649 0.4434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0101
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0198 0.018
Brugia malayi serine/threonine kinase 12 0.0142 0.1464 0.2436
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis growth factor receptor bound protein 2 0.0042 0.0141 0.0124
Plasmodium falciparum serine/threonine protein kinase, putative 0.0142 0.1464 0.2633
Loa Loa (eye worm) hypothetical protein 0.0097 0.087 0.1435
Echinococcus granulosus endoplasmin 0.0348 0.4204 0.4878
Entamoeba histolytica tyrosin kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Brugia malayi hypothetical protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.2194 0.3666
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0033 0.0026 0.0013
Echinococcus granulosus tyrosine protein kinase 0.0033 0.0026 0.0009
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0097 0.087 0.1545
Schistosoma mansoni serine/threonine kinase 0.0167 0.1807 0.2119
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0033 0.0026 0.0009
Brugia malayi MAP kinase sur-1 0.007 0.051 0.0829
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0142 0.1464 0.1685
Entamoeba histolytica tyrosin kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Echinococcus multilocularis neuroglian 0.0084 0.0703 0.0686
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Trypanosoma brucei protein kinase, putative 0.0083 0.0693 0.1222
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0097 0.087 0.077
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0244 0.0263
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0592 0.1036
Schistosoma mansoni tyrosine kinase 0.0108 0.1013 0.1178
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0581 0.0656
Trichomonas vaginalis cyclin A, putative 0.0037 0.0082 0.0116
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0042 0.0141 0.0208
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Onchocerca volvulus 0.0059 0.0365 0.0684
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0179 0.1962 0.3884
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0244 0.0263
Brugia malayi Csnk2b protein 0.0043 0.0155 0.023
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0097 0.087 0.1545
Brugia malayi Protein kinase domain containing protein 0.0331 0.3981 0.6677
Plasmodium falciparum heat shock protein 90, putative 0.0179 0.1962 0.3545
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0058 0.0355 0.0338
Trypanosoma brucei myosin heavy chain kinase A, putative 0.0037 0.0078 0.0096
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0179 0.1962 0.2265
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0179 0.1962 0.3575
Schistosoma mansoni protein kinase 0.0044 0.0166 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus tyrosine protein kinase Lyn 0.0086 0.0721 0.082
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0447 0.0785
Schistosoma mansoni serine/threonine RGC 0.0033 0.0026 0.0009
Schistosoma mansoni heat shock protein 0.0179 0.1962 0.2302
Echinococcus multilocularis transfer RNA-Thr 0.0226 0.259 0.2576
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis mitogen activated protein kinase 0.007 0.051 0.0493
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0075 0.0581 0.0656
Brugia malayi GSG2 0.008 0.0646 0.1059
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0097 0.087 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0044 0.0046
Brugia malayi ephrin receptor 1 precursor 0.0033 0.0026 0.0013
Plasmodium vivax protein kinase Crk2 0.0061 0.0389 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0097 0.087 0.077
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni tyrosine kinase 0.053 0.6621 0.7821
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0076 0.0069
Plasmodium falciparum transporter, putative 0.005 0.0244 0.0399
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0066 0.0465 0.0521
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Onchocerca volvulus 0.0033 0.0026 0.0005
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0221 0.2516 0.291
Echinococcus granulosus serine:threonine protein kinase haspin 0.008 0.0646 0.0732
Toxoplasma gondii ck2 beta subunit 0.0043 0.0155 0.0236
Trypanosoma brucei cdc2-related kinase 1 0.0061 0.0389 0.0665
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0206 0.2317 0.2679
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0089 0.0763 0.1255
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0035 0.0044 0.003
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0537 0.0874
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0059 0.0365 0.0347
Echinococcus multilocularis epidermal growth factor receptor 0.0344 0.4146 0.4136
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0044 0.0166 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1464 0.2643
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.038
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.0044 0.0166 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0355 0.0399
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.023 0.2635 0.3099
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Trypanosoma brucei myosin heavy chain kinase A, putative 0.0037 0.0078 0.0096
Echinococcus multilocularis tyrosine protein kinase 0.0033 0.0026 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Trypanosoma brucei mitotic cyclin 6 0.0037 0.0082 0.0103
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) hypothetical protein 0.0072 0.0537 0.0874
Echinococcus granulosus tyrosine protein kinase ABL1 0.03 0.3568 0.4137
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.007 0.051 0.0887
Plasmodium vivax glycogen synthase kinase 3, putative 0.0066 0.0465 0.0804
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Brugia malayi Protein kinase domain containing protein 0.0206 0.2318 0.3875
Echinococcus multilocularis endoplasmin 0.0348 0.4204 0.4193
Entamoeba histolytica casein kinase, putative 0.0089 0.0763 0.139
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0221 0.2516 0.2502
Loa Loa (eye worm) TK/RYK protein kinase 0.0033 0.0026 0.0013
Brugia malayi hypothetical protein 0.0033 0.0023 0.0009
Loa Loa (eye worm) hypothetical protein 0.0072 0.0537 0.0874
Echinococcus granulosus mitogen activated protein kinase 0.007 0.051 0.0573
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Brugia malayi Protein kinase domain containing protein 0.0059 0.0365 0.0584
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1464 0.2643
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Echinococcus multilocularis tyrosine protein kinase Blk 0.0059 0.0365 0.0347
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0155 0.0236
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Brugia malayi SH2 domain containing protein 0.0059 0.0365 0.0584
Echinococcus multilocularis heat shock protein 0.0445 0.5488 0.548
Echinococcus granulosus tyrosine protein kinase Fyn 0.0075 0.0581 0.0656
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0076 0.0139
Loa Loa (eye worm) CDC7 protein kinase 0.0077 0.0603 0.0986
Echinococcus granulosus tyrosine protein kinase pr2 0.0033 0.0026 0.0009
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0097 0.087 0.077
Echinococcus granulosus activin receptor type 0.0044 0.0166 0.0172
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0355 0.0399
Entamoeba histolytica cyclin, putative 0.0037 0.0082 0.0149
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Entamoeba histolytica tyrosin kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis protein kinase 0.0033 0.0026 0.0007
Onchocerca volvulus 0.0033 0.0026 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1674 0.3019
Echinococcus granulosus NCK adaptor protein 0.0042 0.0141 0.0144
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Trichomonas vaginalis STE family protein kinase 0.0129 0.1301 0.2346
Giardia lamblia Kinase, AGC PKA 0.0035 0.0044 0.0034
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0592 0.1297
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0097 0.087 0.1578
Trichomonas vaginalis cyclin B, putative 0.0037 0.0082 0.0116
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.005 0.0032
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0142 0.1464 0.1448
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0245 0.0227
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Trichomonas vaginalis STE family protein kinase 0.0129 0.1301 0.2346
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Echinococcus granulosus tyrosine protein kinase Srms 0.0059 0.0365 0.0404
Echinococcus granulosus serine threonine protein kinase 0.0129 0.1301 0.1495
Onchocerca volvulus 0.0059 0.0365 0.0684
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0026 0.0013
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0389 0.0439
Trypanosoma cruzi heat shock protein 85, putative 0.0348 0.4204 0.765
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0244 0.0263
Trypanosoma brucei aurora B kinase 0.0142 0.1464 0.2633
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.007 0.051 0.0887
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0035 0.005 0.0037
Brugia malayi map kinase activated protein kinase protein 2 0.0221 0.2516 0.4208
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0058 0.0355 0.0393
Leishmania major developmentally regulated phosphoprotein-like protein 0.0228 0.2615 0.474
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1464 0.2643
Trichomonas vaginalis cyclins, putative 0.0037 0.0082 0.0116
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0348 0.4204 1
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Echinococcus granulosus serine/threonine protein kinase 0.0037 0.0076 0.0067
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.007 0.051 0.0887
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0066 0.0465 0.0529
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0033 0.0026 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0772 0.127
Brugia malayi intracellular kinase 0.0066 0.0465 0.0753
Trypanosoma cruzi cdc2-related kinase 1 0.0061 0.0389 0.0665
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0033 0.0026 0.0013
Giardia lamblia Kinase, CDC7 0.0077 0.0603 0.1057
Brugia malayi Protein kinase domain containing protein 0.0094 0.0839 0.1383
Trypanosoma brucei DNA topoisomerase ii 0.0097 0.087 0.1545
Echinococcus granulosus twitchin 0.0095 0.0843 0.0961
Loa Loa (eye worm) hypothetical protein 0.0193 0.215 0.3592
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Mycobacterium leprae Probable two-component sensor kinase 0.0097 0.087 0.1578
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0061 0.0389 0.0665
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0033 0.0026 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0348 0.4204 0.7653
Echinococcus multilocularis tyrosine protein kinase csk 0.0033 0.0026 0.0007
Brugia malayi Kinase associated domain 1 family protein 0.0047 0.0215 0.0332
Echinococcus granulosus natriuretic peptide receptor 1 0.0033 0.0026 0.0009
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0033 0.0026 0.0009
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0155 0.0236
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0026 0.0009
Toxoplasma gondii DNA topoisomerase 2, putative 0.0097 0.087 0.1545
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus tyrosine protein kinase Src42A 0.0075 0.0581 0.0656
Schistosoma mansoni protein kinase 0.0089 0.0763 0.0882
Echinococcus multilocularis cyclin dependent kinase 1 0.0061 0.0389 0.0371
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0041 0.0132 0.0191
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0097 0.087 0.0992
Echinococcus granulosus tyrosine kinase 0.0033 0.0026 0.0009
Chlamydia trachomatis serine/threonine protein kinase 0.0252 0.2927 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.1188 0.2128
Echinococcus granulosus protein kinase C gamma type 0.008 0.065 0.0736
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Echinococcus multilocularis 0.0094 0.0834 0.0817
Trypanosoma cruzi myosin heavy chain kinase A, putative 0.0037 0.0078 0.0096
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Echinococcus multilocularis protein kinase 0.0033 0.0026 0.0007
Loa Loa (eye worm) hypothetical protein 0.0108 0.1013 0.1676
Loa Loa (eye worm) hypothetical protein 0.0046 0.0198 0.0303
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0121 0.1188 0.1971
Echinococcus granulosus geminin 0.0164 0.1762 0.2032
Loa Loa (eye worm) hypothetical protein 0.005 0.0249 0.0388
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0059 0.0365 0.0665
Schistosoma mansoni tyrosine kinase 0.0263 0.3074 0.362
Loa Loa (eye worm) hypothetical protein 0.0037 0.0082 0.0107
Echinococcus multilocularis serine threonine protein kinase 0.008 0.065 0.0633
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0097 0.087 0.1696
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0603 0.0693
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0097 0.087 0.1578
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0392 0.4787 0.5558
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.007 0.051 0.0887
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0097 0.087 0.077
Entamoeba histolytica protein kinase, putative 0.0036 0.0065 0.0118
Brugia malayi Protein kinase domain containing protein 0.0059 0.0368 0.059
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0332
Onchocerca volvulus 0.0059 0.0365 0.0684
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0097 0.087 0.077
Echinococcus granulosus fibroblast growth factor receptor 4 0.0149 0.1557 0.1793
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0142 0.1464 0.2667
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Leishmania major hypothetical protein, conserved 0.0097 0.087 0.1545
Leishmania major casein kinase II, putative 0.0089 0.0763 0.135
Brugia malayi Protein kinase domain containing protein 0.0061 0.0389 0.0625
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0108 0.1013 0.1159
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0097 0.087 0.077
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0042 0.0141 0.0208
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0097 0.087 0.077
Echinococcus multilocularis tyrosine kinase 0.0033 0.0026 0.0007
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Trypanosoma cruzi Heat shock protein 83, putative 0.0445 0.5488 1
Loa Loa (eye worm) serotonin transporter b 0.0292 0.3461 0.5801
Trypanosoma cruzi DNA topoisomerase II, putative 0.0097 0.087 0.1545
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0244 0.0263
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0603 0.107
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.0263 0.3074 0.362
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0097 0.087 0.1545
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0097 0.087 0.1578
Echinococcus multilocularis tyrosine protein kinase pr2 0.0033 0.0026 0.0007
Onchocerca volvulus 0.0066 0.0465 0.0885
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0097 0.087 0.1435
Giardia lamblia Pms1-like protein 0.0097 0.087 0.1545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0772 0.0893
Echinococcus multilocularis calcium activated potassium channel 0.0058 0.0355 0.0338
Schistosoma mansoni tyrosine kinase 0.0328 0.3934 0.4638
Entamoeba histolytica protein kinase 2, putative 0.0035 0.0044 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0772 0.0755
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0244 0.0226
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis DNA topoisomerase II, putative 0.0097 0.087 0.1557
Brugia malayi Protein kinase c protein 2 0.0065 0.0452 0.073
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus serine threonine protein kinase nrc 0.0035 0.0044 0.003
Entamoeba histolytica heat shock protein 90, putative 0.0445 0.5488 1
Schistosoma mansoni sodium/chloride dependent transporter 0.006 0.0384 0.0433
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.087 0.1696
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0058 0.0358 0.0572
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0192 0.0174
Entamoeba histolytica receptor protein kinase, putative 0.0033 0.0026 0.0047
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0129 0.1301 0.2162
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Giardia lamblia G2/mitotic-specific cyclin B 0.0037 0.0082 0.0103
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Plasmodium vivax casein kinase II beta chain, putative 0.0043 0.0155 0.0236
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Schistosoma mansoni cell adhesion molecule 0.0083 0.069 0.0796
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0142 0.1464 0.2667
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Entamoeba histolytica cell division protein kinase 2, putative 0.0074 0.0572 0.1042
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.007 0.051 0.0829
Trichomonas vaginalis TKL family protein kinase 0.0034 0.0044 0.0046
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Brugia malayi serine/threonine protein kinase 6 0.0142 0.1464 0.2436
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0603 0.107
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1464 0.1712
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0389 0.0678
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0059 0.0365 0.0404
Echinococcus multilocularis cyclin B 0.0037 0.0082 0.0064
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0075 0.0581 0.0564
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0033 0.0026 0.0014
Brugia malayi Tyrosine-protein kinase abl-1 0.0167 0.1806 0.3013
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0094 0.0839 0.0822
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0592 0.1297
Trichomonas vaginalis receptor histidine kinase, putative 0.0097 0.087 0.1557
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0043 0.0155 0.0236
Echinococcus granulosus protein kinase c epsilon type 0.0041 0.0132 0.0132
Toxoplasma gondii heat shock protein 75, putative 0.0179 0.1962 0.3545
Loa Loa (eye worm) hypothetical protein 0.0292 0.3461 0.5801
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0228 0.2615 0.2602
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trypanosoma brucei polo-like protein kinase 0.0121 0.1188 0.2128
Plasmodium falciparum protein kinase, putative 0.0129 0.1301 0.2335
Loa Loa (eye worm) hypothetical protein 0.0125 0.125 0.2076
Trichomonas vaginalis heat shock protein, putative 0.0348 0.4204 0.7653
Schistosoma mansoni protein kinase 0.0044 0.0166 0.0175
Echinococcus multilocularis protein KINase family member (kin 25) 0.0108 0.1013 0.0997
Echinococcus granulosus casein kinase ii subunit alpha 0.0089 0.0763 0.0868
Echinococcus granulosus kinase suppressor of Ras 1 0.0033 0.0026 0.0009
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0155 0.0236
Trypanosoma brucei developmentally regulated phosphoprotein 0.0228 0.2615 0.474
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.2318 0.2724
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0044 0.0046
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0344 0.4146 0.6956
Schistosoma mansoni tyrosine kinase 0.0149 0.1557 0.1822
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.1723 0.2872
Entamoeba histolytica protein kinase, putative 0.0033 0.0028 0.005
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Brugia malayi Endoplasmin precursor 0.0445 0.5488 0.9217
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0075 0.0581 0.0564
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0343
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0839 0.1501
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0581 0.0564
Brugia malayi Cyclin, N-terminal domain containing protein 0.0037 0.0082 0.0107
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0033 0.0026 0.0009
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0348 0.4204 1
Echinococcus granulosus heat shock protein 90 0.0445 0.5488 0.6374
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1674 0.1659
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0035 0.0045 0.0045
Entamoeba histolytica cell division protein kinase 2, putative 0.0061 0.0389 0.0709
Entamoeba histolytica protein kinase, putative 0.0059 0.0368 0.0671
Loa Loa (eye worm) TK/DDR protein kinase 0.0033 0.0026 0.0013
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Echinococcus granulosus integrin linked protein kinase 0.0033 0.0026 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.007 0.051 0.0887
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) Csnk2b protein 0.0043 0.0155 0.023
Loa Loa (eye worm) hypothetical protein 0.0096 0.0856 0.1412
Echinococcus granulosus serotonin transporter 0.0292 0.3461 0.4012
Echinococcus multilocularis tyrosine protein kinase csk 0.0033 0.0026 0.0007
Echinococcus granulosus activated cdc42 kinase 1 0.0226 0.259 0.2997
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0033 0.0026 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Loa Loa (eye worm) hypothetical protein 0.0072 0.0539 0.0878
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0097 0.087 0.1578
Echinococcus multilocularis rac serine:threonine kinase 0.0037 0.0076 0.0058
Trypanosoma cruzi myosin heavy chain kinase A, putative 0.0037 0.0078 0.0096
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Leishmania major myosin heavy chain kinase a-like protein 0.0037 0.0078 0.0096
Plasmodium falciparum DNA gyrase subunit B 0.0097 0.087 0.1545
Brugia malayi Hsp90 protein 0.0179 0.1962 0.3276
Schistosoma mansoni growth factor receptor-bound protein 0.0044 0.0166 0.0175
Brugia malayi Protein kinase domain containing protein 0.0059 0.0365 0.0584
Toxoplasma gondii Hsp90 domain-containing protein 0.0179 0.1962 0.3545
Trichomonas vaginalis CAMK family protein kinase 0.0154 0.1624 0.2935
Brugia malayi SRC-1 0.0075 0.0581 0.0949
Onchocerca volvulus 0.0059 0.0365 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0744 0.086
Plasmodium vivax heat shock protein 86, putative 0.0445 0.5488 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trypanosoma cruzi CYC2-like cyclin, putative 0.0037 0.0082 0.0103
Trichomonas vaginalis sensor histidine kinase, putative 0.0097 0.087 0.1557
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0097 0.087 0.1578
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0228 0.2615 0.474
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0097 0.087 0.1557
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1464 0.2436
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0244 0.0267
Trypanosoma brucei rac serine-threonine kinase, putative 0.0059 0.0368 0.0627
Echinococcus multilocularis heat shock protein 90 0.0445 0.5488 0.548
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0465 0.0817
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0097 0.087 0.1545
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0026 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0592 0.0966
Plasmodium vivax hypothetical protein, conserved 0.005 0.0244 0.0399
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0009
Plasmodium falciparum heat shock protein 90, putative 0.0179 0.1962 0.3545
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0033 0.0026 0.0014
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0033 0.0026 0.0013
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Giardia lamblia Kinase, CMGC CK2 0.0089 0.0763 0.135
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0097 0.087 0.1557
Brugia malayi hypothetical protein 0.0033 0.0026 0.0013
Echinococcus multilocularis tumor protein p63 0.0327 0.3931 0.392
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0026 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.1464 0.2667
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Brugia malayi Protein kinase domain containing protein 0.02 0.2243 0.3749
Trypanosoma cruzi heat shock protein 90, putative 0.0445 0.5488 1
Trypanosoma cruzi heat shock protein 90, putative 0.0266 0.3112 0.565
Echinococcus granulosus mitogen activated protein kinase 11 0.0157 0.1674 0.193
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0009
Echinococcus multilocularis serine:threonine protein kinase haspin 0.008 0.0646 0.0629
Entamoeba histolytica cysteine surface protein, putative 0.0033 0.0026 0.0047
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0097 0.087 0.1578
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Leishmania major mitochondrial DNA topoisomerase II 0.0097 0.087 0.1545
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0592 0.1036
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0141 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.8461 1
Trichomonas vaginalis STE family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) heat shock protein 90 0.0445 0.5488 0.9217
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Brugia malayi hypothetical protein 0.008 0.0646 0.1059
Echinococcus multilocularis serotonin transporter 0.0292 0.3461 0.3449
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.3461 0.5801
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0033 0.0026 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Mycobacterium tuberculosis Probable two component sensor kinase 0.0097 0.087 0.1578
Leishmania major heat shock protein, putative 0.0179 0.1962 0.3545
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.1188 0.1386
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0581 0.0564
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0033 0.0026 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Echinococcus multilocularis protein tyrosine kinase 0.0328 0.3934 0.3923
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0097 0.087 0.1545
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0244 0.038
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0058 0.0355 0.0338
Plasmodium vivax hypothetical protein, conserved 0.0097 0.087 0.1545
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0066 0.0465 0.0804
Giardia lamblia Aurora kinase 0.0142 0.1464 0.2633
Mycobacterium ulcerans heat shock protein 90 0.0348 0.4204 1
Loa Loa (eye worm) TK/ABL protein kinase 0.03 0.3568 0.5982
Loa Loa (eye worm) hypothetical protein 0.0072 0.0537 0.0874
Leishmania major protein kinase, putative 0.0044 0.0166 0.0256
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.3461 0.5801
Echinococcus multilocularis tyrosine protein kinase Abl 0.0167 0.1806 0.1791
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0155 0.0282
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0222 0.0241
Echinococcus multilocularis natriuretic peptide receptor 1 0.0033 0.0026 0.0007
Plasmodium falciparum endoplasmin, putative 0.0276 0.3246 0.5896
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0061 0.0389 0.0625
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0033 0.0019 0.0001
Toxoplasma gondii heat shock protein HSP90 0.0445 0.5488 1
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Plasmodium falciparum amino acid transporter, putative 0.005 0.0244 0.0399
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0087 0.0744 0.0727
Trichomonas vaginalis cyclin B, putative 0.0037 0.0082 0.0116
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0145 0.1516 0.2728
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.2516 0.2958
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0066 0.0465 0.0753
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0033 0.0026 0.0013
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0392 0.4787 0.4778
Entamoeba histolytica hypothetical protein 0.0033 0.0028 0.005
Trypanosoma cruzi heat shock protein 85, putative 0.0445 0.5488 1
Giardia lamblia Casein kinase II beta chain 0.0043 0.0155 0.0236
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0465 0.0847
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0244 0.0226
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis kinase suppressor of Ras 1 0.0033 0.0026 0.0007
Echinococcus multilocularis serine threonine protein kinase 0.0129 0.1301 0.1285
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.3461 0.4077
Toxoplasma gondii CMGC kinase, CK2 family 0.0089 0.0763 0.135
Trypanosoma brucei protein kinase, putative 0.0044 0.0166 0.0256
Echinococcus multilocularis c src tyrosine kinase 0.0075 0.0581 0.0564
Trichomonas vaginalis TK family protein kinase 0.0034 0.0044 0.0046
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) hypothetical protein 0.0096 0.0856 0.1412
Echinococcus granulosus tyrosine protein kinase Blk 0.0059 0.0365 0.0404
Loa Loa (eye worm) TK/ALK protein kinase 0.0308 0.3678 0.6167
Echinococcus granulosus Protein kinase C brain isozyme 0.0087 0.0744 0.0846
Schistosoma mansoni ephrin receptor 0.0033 0.0026 0.0009
Onchocerca volvulus 0.0059 0.0365 0.0684
Echinococcus multilocularis aurora kinase A 0.0142 0.1464 0.1448
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0355 0.0399
Echinococcus granulosus cyclin B 0.0037 0.0082 0.0074
Echinococcus granulosus activated cdc42 kinase 1 0.0226 0.259 0.2997
Loa Loa (eye worm) TK/KIN16 protein kinase 0.048 0.5953 1
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0244 0.0267
Brugia malayi Protein kinase domain containing protein 0.0231 0.2649 0.4434
Toxoplasma gondii hypothetical protein 0.005 0.0244 0.0399
Entamoeba histolytica protein kinase, putative 0.0142 0.1464 0.2667
Brugia malayi protein-tyrosine kinase 0.0059 0.0365 0.0584
Leishmania major DNA topoisomerase ii 0.0097 0.087 0.1545
Echinococcus granulosus cyclin dependent kinase 0.0061 0.0389 0.0432
Trichomonas vaginalis CMGC family protein kinase 0.007 0.051 0.0899
Loa Loa (eye worm) SRC-1 0.0075 0.0581 0.0949
Echinococcus multilocularis tyrosine protein kinase Srms 0.0059 0.0365 0.0347
Loa Loa (eye worm) hypothetical protein 0.0072 0.0537 0.0874
Echinococcus granulosus protein kinase c iota type 0.004 0.0112 0.0109
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Mycobacterium leprae Probable two component sensor kinase MprB 0.0097 0.087 0.1578
Loa Loa (eye worm) TOPoisomerase family member 0.0097 0.087 0.1435
Trichomonas vaginalis protein tyrosine kinase, putative 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0097 0.087 0.1545
Loa Loa (eye worm) TK protein kinase 0.0059 0.0365 0.0584
Brugia malayi serine/threonine-protein kinase plk-2 0.0121 0.1188 0.1971
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0049 0.0232 0.0378
Schistosoma mansoni vav2 0.0035 0.0051 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0097 0.087 0.2333
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0368 0.064
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0006
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0042 0.0141 0.0146
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis receptor type guanylyl cyclase 0.0033 0.0026 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0592 0.0679
Entamoeba histolytica ankyrin repeat protein 0.0033 0.0026 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.007 0.051 0.0899
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus mitogen activated protein kinase 14 0.0157 0.1674 0.193
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0026 0.0014
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0061 0.0389 0.0625
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0033 0.0019 0.0001
Schistosoma mansoni hypothetical protein 0.0047 0.0215 0.0233
Treponema pallidum heat shock protein 90 0.0348 0.4204 1
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Plasmodium vivax heat shock protein 90, putative 0.0179 0.1962 0.3545
Loa Loa (eye worm) hypothetical protein 0.0242 0.2801 0.4689
Onchocerca volvulus 0.0033 0.0026 0.0005
Giardia lamblia Heat shock protein HSP 90-alpha 0.0348 0.4204 0.765
Echinococcus granulosus tyrosine protein kinase Src64B 0.0075 0.0581 0.0656
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Echinococcus granulosus cyclin dependent kinase 5 0.0061 0.0389 0.0432
Echinococcus granulosus insulin receptor 0.0392 0.4787 0.5558
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0061 0.0389 0.0665
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0149 0.1557 0.1793
Echinococcus multilocularis tyrosine kinase 0.0059 0.0365 0.0347
Leishmania major protein kinase, putative 0.0142 0.1464 0.2633
Trichomonas vaginalis receptor histidine kinase, putative 0.0097 0.087 0.1557
Entamoeba histolytica protein kinase, putative 0.0066 0.0465 0.0847
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0026 0.0009
Schistosoma mansoni nephrin 0.0084 0.0703 0.0811
Entamoeba histolytica hypothetical protein 0.0033 0.0028 0.005
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Onchocerca volvulus 0.0033 0.0026 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0485 0.0552
Brugia malayi Raf kinase 0.0033 0.0026 0.0013
Loa Loa (eye worm) TTK protein kinase 0.0094 0.0839 0.1383
Echinococcus granulosus tyrosine kinase 0.0059 0.0365 0.0404
Echinococcus granulosus tyrosine protein kinase shark 0.0556 0.696 0.8089
Mycobacterium ulcerans two component sensor kinase MprB 0.0097 0.087 0.077
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0129 0.1301 0.2335
Trichomonas vaginalis heat shock protein, putative 0.0276 0.3246 0.5901
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0058 0.0355 0.0393
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0097 0.087 0.1696
Echinococcus granulosus CDC7 cell division cycle 7 0.0077 0.0603 0.0682
Echinococcus multilocularis tyrosine protein kinase ABL1 0.03 0.3568 0.3556
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.8461 0.8458
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0141 0.0208
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0244 0.0226
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0772 0.127
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1674 0.3019
Toxoplasma gondii hypothetical protein 0.005 0.0244 0.0399
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Mycobacterium ulcerans DNA gyrase subunit B 0.0097 0.087 0.077
Giardia lamblia Heat shock protein HSP 90-alpha 0.0445 0.5488 1
Schistosoma mansoni cyclin B 0.0037 0.0082 0.0075
Trypanosoma cruzi cyclin, putative 0.0037 0.0082 0.0103
Schistosoma mansoni hypothetical protein 0.0164 0.1762 0.2066
Brugia malayi Protein kinase domain containing protein 0.0308 0.368 0.617
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0603 0.107
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0036 0.0065 0.0118
Brugia malayi C-terminal src kinase protein 1 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni tyrosine kinase 0.0556 0.696 0.8222
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0033 0.0026 0.0013
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0061 0.0389 0.0625
Trypanosoma cruzi heat shock protein 85, putative 0.0445 0.5488 1
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1301 0.152
Brugia malayi Protein kinase domain containing protein 0.0154 0.1624 0.2705
Plasmodium falciparum DNA topoisomerase 2 0.0097 0.087 0.1545
Echinococcus multilocularis Immunoglobulin 0.0072 0.0537 0.052
Echinococcus granulosus epidermal growth factor receptor 0.0263 0.3074 0.3562
Chlamydia trachomatis DNA gyrase subunit B 0.0097 0.087 0.2333
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0355 0.0399
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0157 0.1674 0.3019
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0097 0.087 0.077
Echinococcus multilocularis cyclin dependent kinase 5 0.0061 0.0389 0.0371
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Onchocerca volvulus 0.005 0.0244 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0026 0.0014
Brugia malayi Sex muscle abnormal protein 5 0.0042 0.0141 0.0208
Trypanosoma brucei heat shock protein 84, putative 0.0179 0.1962 0.3545
Schistosoma mansoni tyrosine kinase 0.0075 0.0581 0.0667
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0154 0.1624 0.2705
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0192 0.0202
Schistosoma mansoni tyrosine kinase 0.0344 0.4146 0.4889
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0244 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0772 0.0893
Schistosoma mansoni protein kinase 0.0044 0.0166 0.0175
Schistosoma mansoni hypothetical protein 0.008 0.0646 0.0744
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0033 0.0026 0.0007
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.2194 0.3666
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0094 0.0839 0.0957
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0035 0.0044 0.0034
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0026 0.0013
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0097 0.087 0.1578
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0033 0.0026 0.0047
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Trypanosoma cruzi polo-like protein kinase, putative 0.0121 0.1188 0.2128
Brugia malayi Variant SH3 domain containing protein 0.0033 0.0019 0.0001
Brugia malayi MHCK/EF2 kinase domain family protein 0.0037 0.0078 0.0101
Echinococcus granulosus microtubule associated protein 2 0.0669 0.8461 0.9839
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0044 0.0166 0.0172
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0198 0.018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.038
Echinococcus granulosus N chimaerin 0.0033 0.0019 0.0001
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.2194 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0034 0.0044 0.0046
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0592 0.0574
Echinococcus granulosus defective proboscis extension response 0.0072 0.0537 0.0605
Entamoeba histolytica protein kinase , putative 0.0142 0.1464 0.2667
Plasmodium vivax unspecified product 0.0089 0.0763 0.135
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0744 0.086
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0097 0.087 0.1578
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0059 0.0365 0.0404
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0026 0.0047
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0244 0.0226
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0244 0.0267
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Brugia malayi Tyrosine-protein kinase PR2 0.0033 0.0026 0.0013
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Onchocerca volvulus 0.005 0.0244 0.0441
Schistosoma mansoni hypothetical protein 0.0047 0.0215 0.0233
Trypanosoma cruzi heat shock protein 90, putative 0.0348 0.4204 0.765
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Brugia malayi serine/threonine-protein kinase PAK 7 0.0224 0.2559 0.4282
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0155 0.0282
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0772 0.0893
Onchocerca volvulus 0.0048 0.0222 0.0398
Trichomonas vaginalis cyclin B, putative 0.0037 0.0082 0.0116
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.2194 0.2536
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0348 0.4204 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Brugia malayi protein kinase C II. 0.0041 0.0132 0.0191
Echinococcus multilocularis protein kinase shaggy 0.0066 0.0465 0.0448
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0206 0.2317 0.2303
Echinococcus granulosus heat shock protein 0.0445 0.5488 0.6374
Brugia malayi RhoGAP domain containing protein 0.0033 0.0019 0.0001
Schistosoma mansoni eukaryotic elongation factor 2 kinase (eef-2 kinase) 0.0037 0.0078 0.0071
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Echinococcus granulosus epidermal growth factor receptor 0.0344 0.4146 0.4811
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.007 0.051 0.0887
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0033 0.0026 0.0007
Toxoplasma gondii heat shock protein 90, putative 0.0445 0.5488 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0026 0.0007
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0033 0.0019 0.0001
Entamoeba histolytica protein kinase, putative 0.0057 0.0337 0.0613
Brugia malayi P38 map kinase family protein 2 0.0157 0.1674 0.2791
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0026 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Echinococcus granulosus cyclin dependent kinase 1 0.0061 0.0389 0.0432
Trypanosoma cruzi cdc2-related kinase 3 0.0061 0.0389 0.0665
Trypanosoma brucei heat shock protein 90, putative 0.0445 0.5488 1
Onchocerca volvulus 0.0033 0.0026 0.0005
Brugia malayi Casein kinase II, alpha chain 0.0089 0.0763 0.1255
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0033 0.0026 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0121 0.1188 0.2165
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Giardia lamblia Kinase, CMGC GSK 0.0066 0.0465 0.0804
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Echinococcus multilocularis serine:threonine protein kinase haspin 0.008 0.0646 0.0629
Brugia malayi Probable DNA topoisomerase II 0.0097 0.087 0.1435
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0033 0.0026 0.0013
Entamoeba histolytica ankyrin repeat protein 0.0033 0.0026 0.0047
Trypanosoma cruzi heat shock protein 85, putative 0.0445 0.5488 1
Trichomonas vaginalis protein kinase atn1, putative 0.0033 0.0026 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1119 0.1855
Loa Loa (eye worm) heat shock protein 75 0.0179 0.1962 0.3276
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0043 0.0155 0.0236
Brugia malayi heat shock protein 90 0.0445 0.5488 0.9217
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Plasmodium vivax endoplasmin, putative 0.0445 0.5488 1
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0089 0.0763 0.0746
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Echinococcus multilocularis geminin 0.0164 0.1762 0.1747
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.2194 0.3666
Onchocerca volvulus 0.005 0.0244 0.0441
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0149 0.1557 0.1541
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Loa Loa (eye worm) hypothetical protein 0.0167 0.1803 0.3008
Loa Loa (eye worm) hypothetical protein 0.0059 0.0365 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0994 0.1785
Brugia malayi Immunoglobulin I-set domain containing protein 0.048 0.5953 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0043 0.0155 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0355 0.0399
Giardia lamblia Kinase, CMGC MAPK 0.007 0.051 0.0887
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0263 0.3074 0.3562
Echinococcus multilocularis Immunoglobulin 0.0072 0.0537 0.052
Loa Loa (eye worm) haspin protein kinase 0.009 0.0787 0.1295
Toxoplasma gondii aurora kinase 0.0142 0.1464 0.2633
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0033 0.0026 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Echinococcus granulosus serine:threonine protein kinase haspin 0.008 0.0646 0.0732
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0026 0.0009
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0026 0.0007
Schistosoma mansoni growth factor receptor-bound protein 0.0042 0.0141 0.0146
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0026 0.0014
Giardia lamblia Kinase, CMGC CDK 0.0061 0.0389 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.1188 0.2139
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0006
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0106 0.0994 0.1138
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Mycobacterium tuberculosis Conserved protein 0.0097 0.087 0.1578
Echinococcus granulosus eukaryotic elongation factor 2 kinase 0.0037 0.0078 0.007
Schistosoma mansoni casein kinase II beta subunit 0.0043 0.0155 0.0162
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0033 0.0019 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0224 0.2559 0.4282
Echinococcus multilocularis tyrosine protein kinase csk 0.0033 0.0026 0.0007
Echinococcus multilocularis cyclin dependent kinase 0.0061 0.0389 0.0371
Schistosoma mansoni DNA topoisomerase II 0.0097 0.087 0.1009
Schistosoma mansoni tyrosine kinase 0.0075 0.0581 0.0667
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Echinococcus granulosus tyrosine protein kinase csk 0.0033 0.0026 0.0009
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni tyrosine kinase 0.0075 0.0581 0.0667
Loa Loa (eye worm) TK/FAK protein kinase 0.0331 0.3981 0.6677
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0033 0.0026 0.0007
Schistosoma mansoni endoplasmin 0.0445 0.5488 0.6479
Brugia malayi Protein kinase domain containing protein 0.0197 0.2194 0.3666
Entamoeba histolytica DNA topoisomerase II, putative 0.0097 0.087 0.1585
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0155 0.0263
Schistosoma mansoni pyruvate dehydrogenase 0.0132 0.1331 0.1555
Schistosoma mansoni tyrosine kinase 0.023 0.2635 0.3099
Schistosoma mansoni tyrosine kinase 0.023 0.2635 0.3099
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trypanosoma cruzi aurora B kinase, putative 0.0142 0.1464 0.2633
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0097 0.087 0.077
Schistosoma mansoni adapter molecule crk 0.0042 0.0141 0.0146
Echinococcus multilocularis roundabout 2 0.0096 0.0856 0.084
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis cyclins, putative 0.0037 0.0082 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0839 0.1501
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1674 0.1659
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0097 0.087 0.077
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) endoplasmin 0.0445 0.5488 0.9217
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0166 0.0256
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.3461 0.5801
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0179 0.1962 0.1947
Loa Loa (eye worm) hypothetical protein 0.0074 0.0573 0.0935
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.007 0.051 0.0887
Echinococcus multilocularis insulin receptor 0.0392 0.4787 0.4778
Schistosoma mansoni hypothetical protein 0.0164 0.1762 0.2066
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.3461 0.7942
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0026 0.0013
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0097 0.087 0.1435
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Mycobacterium ulcerans putative regultory protein 0.0097 0.087 0.077
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0447 0.0785
Echinococcus granulosus growth factor receptor bound protein 2 0.0044 0.0166 0.0172
Brugia malayi Receptor family ligand binding region containing protein 0.0033 0.0026 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Echinococcus multilocularis heat shock protein 90 0.0348 0.4204 0.4193
Loa Loa (eye worm) protein kinase domain-containing protein 0.0033 0.0026 0.0013
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0026 0.0009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0075 0.0581 0.0564
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0026 0.0009
Entamoeba histolytica heat shock protein 90, putative 0.0445 0.5488 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0089 0.0763 0.135
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0097 0.087 0.1557
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0075 0.0581 0.0656
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0142 0.1464 0.2633
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0348 0.4204 0.765
Entamoeba histolytica PH domain containing protein kinase, putative 0.0037 0.0076 0.0139
Echinococcus granulosus calcium activated potassium channel 0.0058 0.0355 0.0393
Echinococcus granulosus aurora kinase A 0.0142 0.1464 0.1685
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0244 0.0263
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0592 0.0668
Giardia lamblia Kinase, PLK 0.0121 0.1188 0.2128
Trypanosoma brucei protein kinase, putative 0.0066 0.0465 0.0804
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0121 0.1188 0.1363
Brugia malayi Protein kinase domain containing protein 0.0226 0.259 0.4333
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0763 0.1362
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0033 0.0026 0.0014
Echinococcus granulosus MAM 0.0033 0.0023 0.0006
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0244 0.0267
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0097 0.087 0.1545
Echinococcus granulosus protein tyrosine kinase 0.0328 0.3934 0.4563
Schistosoma mansoni tyrosine kinase 0.0061 0.0389 0.044
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Brugia malayi SH2 domain containing protein 0.0059 0.0365 0.0584
Entamoeba histolytica serine/threonine kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni atypical protein kinase C 0.004 0.0112 0.0111
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0061 0.0389 0.0665
Echinococcus multilocularis ephrin type A receptor 4 A 0.0033 0.0026 0.0007
Schistosoma mansoni protein kinase 0.0231 0.2649 0.3116
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0348 0.4204 0.4878
Brugia malayi hypothetical protein 0.0059 0.0365 0.0584
Echinococcus multilocularis protein kinase c epsilon type 0.0041 0.0132 0.0114
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0592 0.1036
Echinococcus granulosus tyrosine kinase 0.0059 0.0365 0.0404
Schistosoma mansoni protein kinase 0.0142 0.1464 0.1712
Brugia malayi Protein kinase domain containing protein 0.0059 0.0365 0.0584
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0083 0.069 0.1132
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Schistosoma mansoni pyruvate dehydrogenase 0.0132 0.1331 0.1555
Loa Loa (eye worm) TK protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0033 0.0026 0.0009
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Schistosoma mansoni protein kinase 0.0033 0.0026 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1464 0.2643
Plasmodium vivax DNA topoisomerase II, putative 0.0097 0.087 0.1545
Trichomonas vaginalis heat shock protein, putative 0.0445 0.5488 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0244 0.0267
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0094 0.0839 0.0972
Schistosoma mansoni tyrosine kinase 0.0075 0.0581 0.0667
Entamoeba histolytica protein kinase, putative 0.0059 0.0368 0.0671
Brugia malayi Tyrosine-protein kinase abl-1 0.0149 0.1564 0.2605
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0044 0.0166 0.0148
Echinococcus multilocularis cyclin dependent kinase 1 0.0061 0.0389 0.0371
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0097 0.087 0.1578
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0389 0.0678
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0075 0.0581 0.0564
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0763 0.139
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0043 0.0155 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.007 0.051 0.0583
Trypanosoma cruzi cdc2-related kinase 3 0.0061 0.0389 0.0665
Loa Loa (eye worm) hypothetical protein 0.0097 0.087 0.1435
Trypanosoma cruzi DNA topoisomerase II, putative 0.0097 0.087 0.1545
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1464 0.2436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0772 0.0879
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0198 0.021
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0033 0.0026 0.0007
Echinococcus multilocularis MAM 0.0033 0.0023 0.0005
Brugia malayi hypothetical protein 0.0072 0.0537 0.0874
Trypanosoma brucei heat shock protein, putative 0.0445 0.5488 1
Schistosoma mansoni tyrosine kinase 0.0392 0.4787 0.5649
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0097 0.087 0.1545
Trichomonas vaginalis cyclins, putative 0.0037 0.0082 0.0116
Echinococcus granulosus neuroglian 0.0084 0.0703 0.0798
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0033 0.0026 0.0047
Brugia malayi cell division control protein 2 homolog 0.0061 0.0389 0.0625
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0013
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Echinococcus granulosus receptor type guanylyl cyclase 0.0033 0.0026 0.0009
Echinococcus multilocularis CDC7 cell division cycle 7 0.0077 0.0603 0.0586
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0157 0.1674 0.3019
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.0365 0.0584
Echinococcus multilocularis NCK adaptor protein 0.0044 0.0166 0.0148
Plasmodium falciparum protein kinase 5 0.0061 0.0389 0.0665
Onchocerca volvulus 0.0037 0.0082 0.0117
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Schistosoma mansoni protein tyrosine kinase 0.0033 0.0026 0.0009
Giardia lamblia Grp94/Hsp90 0.0348 0.4204 0.765
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0072 0.0537 0.052
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0228 0.2615 0.3026
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0994 0.1785
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0389 0.0678
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0075 0.0581 0.0564
Brugia malayi Protein kinase domain containing protein 0.0392 0.4787 0.8036
Echinococcus granulosus heat shock protein 90 0.0348 0.4204 0.4878
Onchocerca volvulus 0.0033 0.0026 0.0005
Trypanosoma cruzi cyclin, putative 0.0037 0.0082 0.0103
Plasmodium falciparum casein kinase II beta chain 0.0043 0.0155 0.0236
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0043 0.0155 0.0236
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0228 0.2615 0.2602
Trichomonas vaginalis CMGC family protein kinase 0.007 0.051 0.0899
Brugia malayi Serine/threonine-protein kinase Nek7 0.0252 0.2927 0.4901
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0033 0.0026 0.0009
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0033 0.0026 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Onchocerca volvulus 0.0033 0.0026 0.0005
Plasmodium falciparum glycogen synthase kinase 3 0.0066 0.0465 0.0804
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0033 0.0028 0.005
Loa Loa (eye worm) TK/Met protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0465 0.0817
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni vesicular amine transporter 0.0072 0.0537 0.0615
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.0399
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Brugia malayi bone morphogenetic protein type 1 receptor 0.0033 0.0026 0.0013
Trypanosoma brucei Heat shock protein 83, putative 0.0445 0.5488 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0573 0.0935
Echinococcus multilocularis activated cdc42 kinase 1 0.0226 0.259 0.2576
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0201 0.0335
Trichomonas vaginalis AGC family protein kinase 0.0035 0.005 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0043 0.0155 0.0282
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0221 0.2516 0.4208
Echinococcus granulosus roundabout 2 0.0096 0.0856 0.0977
Loa Loa (eye worm) TK/CSK protein kinase 0.0033 0.0026 0.0013
Schistosoma mansoni heat shock protein 0.0445 0.5488 0.6479
Brugia malayi Probable ClpP-like protease 0.0076 0.0592 0.0966
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0033 0.0026 0.0013
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1464 0.2436
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.2927 0.3445
Mycobacterium ulcerans two component regulator - sensor kinase 0.0097 0.087 0.077
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0026 0.0013
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0228 0.2615 0.4376
Trypanosoma brucei heat shock protein 90, putative 0.0445 0.5488 1
Leishmania major heat shock protein 83-1 0.0445 0.5488 1
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0044 0.0034
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0061 0.0389 0.0432
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0097 0.087 0.1578
Entamoeba histolytica protein kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0097 0.087 0.1557
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0244 0.038
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni pyruvate dehydrogenase 0.0228 0.2615 0.3076
Echinococcus granulosus tyrosine protein kinase csk 0.0033 0.0026 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0044 0.0166 0.0256
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Giardia lamblia Kinase, TTK 0.0094 0.0839 0.1489
Echinococcus granulosus protein kinase shaggy 0.0066 0.0465 0.0521
Loa Loa (eye worm) serine/threonine protein kinase 0.0033 0.0026 0.0013
Entamoeba histolytica protein kinase, putative 0.0142 0.1464 0.2667
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0206 0.2318 0.3875
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0075 0.0136
Entamoeba histolytica hypothetical protein 0.0033 0.0026 0.0047
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0043 0.0155 0.0236
Echinococcus granulosus raf serine:threonine protein kinase 0.004 0.012 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.3461 0.4077
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0244 0.0263
Echinococcus multilocularis N chimaerin 0.0033 0.0019 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Brugia malayi p70 ribosomal S6 kinase beta 0.0057 0.0337 0.0536
Onchocerca volvulus 0.0077 0.0603 0.1162
Brugia malayi Guanylyl cyclase protein 23 0.0033 0.0026 0.0013
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0097 0.087 0.0853
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0462
Echinococcus multilocularis protein kinase c iota type 0.004 0.0112 0.0094
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0066 0.0465 0.0753
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1674 0.1659
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0026 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1119 0.1855
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0772 0.0879
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Trypanosoma cruzi heat shock protein, putative 0.0179 0.1962 0.3545
Loa Loa (eye worm) TK protein kinase 0.0161 0.1723 0.2872
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0389 0.0439
Entamoeba histolytica protein kinase, putative 0.0033 0.0018 0.0033
Plasmodium vivax amine transporter, putative 0.005 0.0244 0.0399
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1674 0.1659
Brugia malayi Fibronectin type III domain containing protein 0.0072 0.0537 0.0874
Plasmodium falciparum heat shock protein 90 0.0445 0.5488 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.2194 0.218
Echinococcus multilocularis heat shock protein 70 0.0033 0.0026 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.007 0.051 0.0887
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0132 0.0134
Echinococcus granulosus mitogen activated protein kinase 3 0.007 0.051 0.0573
Brugia malayi hypothetical protein 0.005 0.0244 0.038
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0033 0.0019 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0244 0.0267
Echinococcus multilocularis mitogen activated protein kinase 3 0.007 0.051 0.0493
Brugia malayi Protein kinase domain containing protein 0.0033 0.0026 0.0013
Echinococcus multilocularis integrin linked protein kinase 0.0033 0.0026 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0026 0.0013
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Brugia malayi MH2 domain containing protein 0.0116 0.1119 0.1855
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Schistosoma mansoni tyrosine protein kinase 0.0033 0.0026 0.0009
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0083 0.069 0.0783
Loa Loa (eye worm) haspin protein kinase 0.008 0.0646 0.1059
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0244 0.0267
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0592 0.0875
Trichomonas vaginalis TKL family protein kinase 0.0033 0.0026 0.0014
Onchocerca volvulus 0.0363 0.4409 0.8786
Schistosoma mansoni tyrosine kinase 0.0051 0.0268 0.0296
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0097 0.087 0.1545
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0097 0.087 0.1578
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0075 0.0581 0.0564
Toxoplasma gondii AGC kinase 0.0057 0.0337 0.0569
Echinococcus granulosus tyrosine protein kinase csk 0.0033 0.0026 0.0009
Schistosoma mansoni tyrosine kinase 0.0275 0.3229 0.3803
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0097 0.087 0.077
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0066 0.0465 0.0804
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0292 0.3461 0.5801
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0121 0.1188 0.1172
Brugia malayi Protein kinase domain containing protein 0.0059 0.0365 0.0584
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0072 0.0537 0.0615
Entamoeba histolytica tyrosine kinase, putative 0.0033 0.0026 0.0047
Plasmodium vivax heat shock protein, putative 0.0179 0.1962 0.3545
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0679 0.8599 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0772 0.0755
Onchocerca volvulus 0.0292 0.3461 0.6887
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0245 0.0264
Loa Loa (eye worm) hypothetical protein 0.0072 0.0537 0.0874
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.3461 0.5801
Onchocerca volvulus 0.0033 0.0026 0.0005
Schistosoma mansoni serine/threonine-protein kinase 0.0037 0.0076 0.0069
Echinococcus granulosus ephrin type A receptor 4 A 0.0033 0.0026 0.0009
Schistosoma mansoni ephrin receptor 0.0033 0.0026 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.007 0.051 0.0899
Mycobacterium tuberculosis Possible two component sensor kinase 0.0097 0.087 0.1578
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0075 0.0581 0.0564
Echinococcus multilocularis raf serine:threonine protein kinase 0.004 0.012 0.0102
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0097 0.087 0.077
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.038
Onchocerca volvulus 0.0033 0.0026 0.0005
Schistosoma mansoni tyrosine kinase 0.0057 0.0345 0.0387
Trichomonas vaginalis casein kinase II beta chain, putative 0.0043 0.0155 0.025
Schistosoma mansoni endoplasmin 0.0445 0.5488 0.6479
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0066 0.0465 0.0448
Schistosoma mansoni tyrosine kinase 0.0033 0.0026 0.0009
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0592 0.1036
Echinococcus granulosus serine:threonine protein kinase haspin 0.008 0.0646 0.0732

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to 5HT2b receptor at 500 nM to 2 uM ChEMBL. 18954981
IC50 (ADMET) = 5000 nM Inhibition of CYP2D6 ChEMBL. 18954981
IC50 (binding) > 10000 nM Inhibition of norepinephrine uptake at human NET transfected in HEK cells ChEMBL. 18954981
IC50 (binding) > 10000 nM Inhibition of serotonin uptake at human SERT transfected in HEK cells ChEMBL. 18954981
IC50 (binding) > 10000 nM Inhibition of dopamine uptake at human DAT transfected in HEK cells ChEMBL. 18954981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.