Detailed information for compound 1211645

Basic information

Technical information
  • TDR Targets ID: 1211645
  • Name: 6,7,8-trimethoxy-N-(3,4,5-trimethoxyphenyl)qu inazolin-4-amine hydrochloride
  • MW: 437.874 | Formula: C20H24ClN3O6
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cc(cc1OC)Nc1ncnc2c1cc(OC)c(c2OC)OC.Cl
  • InChi: 1S/C20H23N3O6.ClH/c1-24-13-7-11(8-14(25-2)17(13)27-4)23-20-12-9-15(26-3)18(28-5)19(29-6)16(12)21-10-22-20;/h7-10H,1-6H3,(H,21,22,23);1H
  • InChiKey: AORDWUVOZGCMIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7,8-trimethoxy-N-(3,4,5-trimethoxyphenyl)-4-quinazolinamine hydrochloride
  • (3,4,5-trimethoxyphenyl)-(6,7,8-trimethoxyquinazolin-4-yl)amine hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0611 0.0611
Brugia malayi intermediate filament protein 0.0025 0.0098 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0099 0.0342
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0498 0.0498
Onchocerca volvulus 0.0056 0.0334 0.2096
Toxoplasma gondii ABC1 family protein 0.0079 0.0498 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0498 0.1371
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0056 0.0334 0.2096
Plasmodium falciparum glutathione reductase 0.0039 0.0208 0.8396
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0334 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0208 0.4007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0334 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0013 0.0014 0.002
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0013 0.0014 0.0037
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0023 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0747 0.0747
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0143 0.0329
Brugia malayi beta-tubulin, identical 0.0044 0.0245 0.0573
Onchocerca volvulus Alhambra homolog 0.0029 0.0128 0.0786
Onchocerca volvulus 0.0025 0.0098 0.0594
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0581 0.1599
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0498 0.1938
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Echinococcus granulosus jumonji domain containing protein 0.004 0.0212 0.0211
Echinococcus multilocularis tubulin subunit beta 0.0044 0.0245 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0225 0.0225
Brugia malayi Subtilase family protein 0.0025 0.0099 0.0224
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0025 0.0099 0.0272
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0128 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Brugia malayi AKH receptor 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0049 0.028 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0452 0.0451
Brugia malayi jmjC domain containing protein 0.0094 0.0611 0.1449
Echinococcus granulosus serotonin receptor 0.0056 0.0334 0.0334
Echinococcus granulosus glycoprotein Antigen 5 0.0012 0.0005 0.0005
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0025 0.0099 0.1763
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0005 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0017 0.0246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0129
Entamoeba histolytica tubulin family protein 0.0044 0.0245 0.3153
Onchocerca volvulus 0.0056 0.0334 0.2096
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0334 0.0334
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0014 0.0031
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0389
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0334 0.0334
Brugia malayi Tubulin beta-1 chain 0.0044 0.0245 0.0573
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0389
Loa Loa (eye worm) hypothetical protein 0.0226 0.1592 0.38
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0225
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0334 0.0796
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0334 0.0334
Brugia malayi Dopamine receptor 0.0056 0.0334 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Loa Loa (eye worm) DR-78 0.0014 0.0023 0.0053
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0212 0.0211
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.0014 0.017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0334 0.0334
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0056 0.0334 0.0334
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi G-protein coupled receptor 0.0056 0.0334 0.0786
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0017 0.0077
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0025 0.0099 0.0099
Brugia malayi jmjC domain containing protein 0.0036 0.0185 0.043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0056 0.0334 0.2096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0129 0.0129
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Brugia malayi ORL1-like opioid receptor 0.0056 0.0334 0.0786
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0498 0.1371
Echinococcus multilocularis Tubulin beta 2C chain 0.0044 0.0245 0.0244
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0025 0.0099 0.1763
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0136 0.0925 0.0925
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0581 0.1599
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0334 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0452 0.0451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0225 0.0225
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0025 0.0099 0.1903
Loa Loa (eye worm) hypothetical protein 0.0233 0.1645 0.3926
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0025 0.0099 0.0224
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0045 0.0247 0.4915
Brugia malayi RE15519p 0.0056 0.0334 0.0786
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0334 0.0334
Trypanosoma brucei beta tubulin 0.0044 0.0245 0.3501
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0079 0.0498 0.1178
Schistosoma mansoni biogenic amine receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis Mastin 0.0012 0.0005 0.0005
Echinococcus granulosus sex peptide receptor 0.0056 0.0334 0.0334
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Entamoeba histolytica acyl-coA synthetase, putative 0.0045 0.0247 0.3189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0389
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0143 0.0329
Echinococcus granulosus beta tubulin 0.0044 0.0245 0.0244
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0099 0.0099
Schistosoma mansoni neuropeptide receptor 0.0056 0.0334 0.0334
Brugia malayi nuclear receptor NHR-88 0.0014 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0655 0.1803
Loa Loa (eye worm) beta-tubulin 0.0044 0.0245 0.0582
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0143 0.0329
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0017 0.5
Schistosoma mansoni hypothetical protein 0.0056 0.0334 0.0334
Echinococcus granulosus GPCR family 2 0.0074 0.0463 0.0463
Brugia malayi hypothetical protein 0.0016 0.0036 0.0074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0334 0.0796
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0143 0.0143
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0334 0.0796
Plasmodium falciparum subtilisin-like protease 2 0.0025 0.0099 0.3694
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0498 0.1371
Onchocerca volvulus 0.0091 0.059 0.3725
Echinococcus multilocularis Tubulin beta 2C chain 0.0044 0.0245 0.0244
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0446 0.3218 0.3218
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0334 0.0334
Brugia malayi hypothetical protein 0.0446 0.3218 0.7681
Echinococcus granulosus cpg binding protein 0.003 0.0137 0.0136
Onchocerca volvulus 0.0014 0.0023 0.0115
Echinococcus multilocularis serotonin receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0112 0.0743 0.2918
Trichomonas vaginalis tubulin beta chain, putative 0.0044 0.0245 0.0925
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0334 0.0334
Brugia malayi steroid hormone receptor 0.0031 0.0143 0.0329
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0452 0.1068
Plasmodium falciparum thioredoxin reductase 0.0014 0.0017 0.0162
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi sulfakinin receptor protein 0.0056 0.0334 0.0786
Brugia malayi nuclear hormone receptor 0.0014 0.0023 0.0043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0014 0.002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0017 0.0057
Echinococcus granulosus Tubulin beta 2C chain 0.0044 0.0245 0.0244
Echinococcus multilocularis membrane bound transcription factor site 1 0.0025 0.0099 0.0099
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0655 1
Entamoeba histolytica hypothetical protein 0.0112 0.0747 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0143 0.0339
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0143 0.0143
Giardia lamblia Beta tubulin 0.0044 0.0245 0.153
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0091 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0043
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0334 0.0334
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0247 0.0579
Echinococcus multilocularis lamin 0.0025 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0234
Brugia malayi ecdysone receptor 0.0014 0.0023 0.0043
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0589
Echinococcus granulosus somatostatin receptor 0.0056 0.0334 0.0334
Echinococcus granulosus survival motor neuron protein 1 0.0446 0.3218 0.3218
Loa Loa (eye worm) endoprotease bli-4 0.0577 0.4189 1
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0334 0.0334
Brugia malayi Calcitonin receptor-like protein seb-1 0.0233 0.1645 0.392
Echinococcus multilocularis ephrin type A receptor 4 A 0.0125 0.0844 0.0844
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0334 0.0334
Brugia malayi Melatonin receptor type 1A 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0029 0.0128 0.0305
Schistosoma mansoni hypothetical protein 0.0319 0.2282 0.2282
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0212 0.0211
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0247 0.3646
Onchocerca volvulus 0.0056 0.0334 0.2096
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0452 0.0451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0143 0.0143
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0012 0.0005 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0334 0.0334
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus granulosus neuropeptide s receptor 0.0476 0.344 0.344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0225 0.0225
Plasmodium vivax subtilisin-like serine protease, putative 0.0025 0.0099 0.1763
Toxoplasma gondii subtilisin SUB9 0.0025 0.0099 0.1763
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0014 0.0021
Schistosoma mansoni myosin xvIII 0.0056 0.0334 0.0334
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0334 0.0334
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis tubulin gamma chain, putative 0.0044 0.0245 0.0925
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0013 0.0014 0.0037
Trypanosoma brucei RNA helicase, putative 0.0102 0.0674 1
Loa Loa (eye worm) oxidoreductase 0.0013 0.0014 0.003
Loa Loa (eye worm) tubulin beta-1 chain 0.0044 0.0245 0.0582
Loa Loa (eye worm) proprotein convertase 2 0.0136 0.0925 0.2208
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Brugia malayi nuclear receptor NHR-67 0.0014 0.0023 0.0043
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0498 0.1938
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.344 0.344
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0498 0.1371
Echinococcus granulosus Mastin 0.0012 0.0005 0.0005
Brugia malayi Serotonin receptor 0.0056 0.0334 0.0786
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0033 0.0164 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0334 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0225 0.0225
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0498 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0128 0.2373
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0334 0.0334
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0029 0.0128 0.0128
Echinococcus multilocularis beta tubulin 0.0044 0.0245 0.0244
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.344 0.344
Loa Loa (eye worm) hypothetical protein 0.0124 0.0834 0.199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0143 0.0143
Schistosoma mansoni amine GPCR 0.0056 0.0334 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0452 0.0451
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0074 0.0463 0.1095
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0143 0.0329
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0143 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0129
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Plasmodium falciparum acyl-CoA synthetase 0.0033 0.0164 0.6495
Onchocerca volvulus 0.0056 0.0334 0.2096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0098 0.0233
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0334 0.0334
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0013 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Toxoplasma gondii subtilisin SUB12 0.0025 0.0099 0.1763
Schistosoma mansoni cpg binding protein 0.0028 0.0125 0.0124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0025 0.0099 0.0272
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0185 0.0185
Trichomonas vaginalis hypothetical protein 0.0112 0.0743 0.2918
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0099 0.0342
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0225 0.0225
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0074 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Onchocerca volvulus 0.0124 0.0834 0.5282
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0389
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.0014 0.0037
Schistosoma mansoni hypothetical protein 0.0074 0.0463 0.0463
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0589
Brugia malayi G protein-coupled receptor 0.0056 0.0334 0.0786
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0143 0.0143
Brugia malayi Pre-SET motif family protein 0.0197 0.1374 0.3272
Schistosoma mansoni hypothetical protein 0.0074 0.0463 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0366 0.0366
Echinococcus granulosus tar DNA binding protein 0.0072 0.0452 0.0451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi ecdysteroid receptor 0.0031 0.0143 0.0329
Schistosoma mansoni amine GPCR 0.0056 0.0334 0.0334
Toxoplasma gondii subtilisin SUB8 0.0025 0.0099 0.1763
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0129 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0498 0.1938
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0056 0.0334 0.2096
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0025 0.0099 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni amine GPCR 0.0056 0.0334 0.0334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0247 0.0681
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0334 0.0334
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0143 0.0143
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0334 0.0796
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.015 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Brugia malayi beta-lactamase 0.0079 0.0498 0.1178
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0247 0.4828
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0502 0.3632 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0334 0.0334
Echinococcus granulosus g protein coupled receptor 0.0056 0.0334 0.0334
Schistosoma mansoni microtubule-associated protein tau 0.1361 1 1
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0074 0.0463 0.0463
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0012 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0334 0.0334
Echinococcus granulosus neuroendocrine convertase 2 0.0362 0.2601 0.2601
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0185 0.044
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0013 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0112 0.0747 1
Toxoplasma gondii subtilisin SUB11 0.0025 0.0099 0.1763
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0014 0.0037
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0025 0.0099 0.0272
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0143 0.0143
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni amine GPCR 0.0056 0.0334 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0334 0.0334
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.344 0.344
Brugia malayi nuclear receptor NHR-88 0.0031 0.0143 0.0329
Echinococcus multilocularis GPCR, family 2 0.0074 0.0463 0.0463
Toxoplasma gondii beta tubulin 0.0044 0.0245 0.4773
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0334 0.0334
Toxoplasma gondii subtilisin SUB1 0.0025 0.0099 0.1763
Giardia lamblia Beta tubulin 0.0044 0.0245 0.153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Brugia malayi neuropeptide F receptor 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0334 0.0786
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0017 0.0077
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0334 0.2096
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0498 0.1371
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0233
Onchocerca volvulus 0.0013 0.0014 0.0053
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0025 0.0099 0.0272
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0014 0.0037
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0334 0.2096
Trichomonas vaginalis esterase, putative 0.0079 0.0498 0.1938
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0589
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0143 0.0143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0143 0.0329
Echinococcus multilocularis Tubulin beta 2C chain 0.0044 0.0245 0.0244
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni intermediate filament proteins 0.0025 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0112 0.0747 1
Echinococcus multilocularis cpg binding protein 0.003 0.0137 0.0136
Schistosoma mansoni adenoreceptor 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0056 0.0334 0.2096
Trypanosoma brucei beta tubulin 0.0044 0.0245 0.3501
Schistosoma mansoni histamine h1 receptor 0.0056 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0074 0.0463 0.0463
Trypanosoma cruzi beta tubulin, putative 0.0044 0.0245 0.4773
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0334 0.0796
Schistosoma mansoni hypothetical protein 0.0112 0.0747 0.0747
Toxoplasma gondii subtilisin SUB2 0.0025 0.0099 0.1763
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis Tubulin beta 2C chain 0.0044 0.0245 0.0244
Schistosoma mansoni hypothetical protein 0.0056 0.0334 0.0334
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0017 0.0162
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0498 0.0498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0143 0.0329
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0023 0.0043
Loa Loa (eye worm) tubulin beta chain 0.0044 0.0245 0.0582
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.016 0.1098 0.2613
Echinococcus granulosus dnaJ subfamily B 0.0802 0.5857 0.5857
Onchocerca volvulus 0.0025 0.0099 0.0597
Mycobacterium tuberculosis Conserved protein 0.0079 0.0498 0.1371
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.011 0.2001
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0017 0.0015
Onchocerca volvulus 0.0056 0.0334 0.2096
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi Latrophilin receptor protein 2 0.0074 0.0463 0.1095
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.0319 0.2282 0.2282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Echinococcus granulosus enteropeptidase 0.0012 0.0005 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0212 0.0211
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0014 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0143 0.0143
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Mycobacterium tuberculosis Conserved protein 0.0079 0.0498 0.1371
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0013 0.0014 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0014 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0287 0.2041 0.4871
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0208 0.4007
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0128 0.2373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0452 0.0451
Trypanosoma cruzi subtilisin peptidase 0.0025 0.0099 0.1763
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0045 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0802 0.5857 0.5857
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0334 0.0334
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0017 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0577 0.4189 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Onchocerca volvulus 0.0079 0.0498 0.314
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0033 0.0164 0.0451
Trypanosoma brucei subtilisin peptidase 0.0025 0.0099 0.1293
Echinococcus multilocularis somatostatin receptor 0.0056 0.0334 0.0334
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0036 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0498 0.1178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Loa Loa (eye worm) tubulin beta-2A chain 0.0044 0.0245 0.0582
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Brugia malayi Thioredoxin reductase 0.0039 0.0208 0.0484
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Echinococcus granulosus Tubulin beta 2C chain 0.0044 0.0245 0.0244
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Giardia lamblia Beta tubulin 0.0044 0.0245 0.153
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.0014 0.017
Echinococcus multilocularis peregrin 0.0029 0.0128 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0185 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni hypothetical protein 0.0112 0.0743 0.0742
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0247 0.3189
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Schistosoma mansoni acetyl-CoA synthetase 0.0013 0.0014 0.0013
Schistosoma mansoni cpg binding protein 0.003 0.0137 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.015 0.0413
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0128 0.2373
Loa Loa (eye worm) subtilase 0.0025 0.0099 0.0234
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0225 0.0225
Loa Loa (eye worm) beta-lactamase 0.0079 0.0498 0.1187
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0014 0.017
Onchocerca volvulus 0.0045 0.0247 0.1543
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0014 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0143 0.0877
Onchocerca volvulus 0.0056 0.0334 0.2096
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0143 0.0143
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0247 0.4915
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0129
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi Dopamine receptor protein 1 0.0056 0.0334 0.0786
Onchocerca volvulus 0.0013 0.0014 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.2001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.011 0.2001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0143 0.0329
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0334 0.0334
Echinococcus granulosus orexin receptor type 2 0.0056 0.0334 0.0334
Echinococcus multilocularis musashi 0.0025 0.0098 0.0098
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0334 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0143 0.0329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0334 0.0796
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0023 0.0115
Trichomonas vaginalis tubulin epsilon chain, putative 0.0044 0.0245 0.0925
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.015 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0143 0.0339
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0023 0.0115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0017 0.0077
Schistosoma mansoni lamin 0.0025 0.0098 0.0098
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0091 0.059 0.1398
Onchocerca volvulus 0.0056 0.0334 0.2096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Echinococcus granulosus neuropeptide receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Echinococcus granulosus Tubulin beta 2C chain 0.0044 0.0245 0.0244
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0074 0.0463 0.0463
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0143 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0017 0.0077
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0334 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0247 0.4915
Entamoeba histolytica hypothetical protein 0.0112 0.0747 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0025 0.0099 0.1903
Brugia malayi celfurPC protein 0.0465 0.3362 0.8025
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0036 0.0074
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0498 0.1371
Giardia lamblia PHD finger protein 15 0.0029 0.0128 0.0748
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0185 0.0185
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0334 0.0786
Trypanosoma brucei beta tubulin 0.0044 0.0245 0.3501
Plasmodium vivax subtilisin-like protease 2, putative 0.0025 0.0099 0.1763
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Schistosoma mansoni amine GPCR 0.0056 0.0334 0.0334
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0655 0.1803
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Brugia malayi larval opioid receptor 0.0056 0.0334 0.0786
Entamoeba histolytica tubulin family protein 0.0044 0.0245 0.3153
Brugia malayi hypothetical protein 0.0014 0.0023 0.0043
Toxoplasma gondii beta-1 tubulin, putative 0.0044 0.0245 0.4773
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.015 0.0413
Schistosoma mansoni hypothetical protein 0.0074 0.0463 0.0463
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0498 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Echinococcus granulosus ephrin type A receptor 4 A 0.0125 0.0844 0.0844
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0334 0.0334
Echinococcus granulosus geminin 0.0319 0.2282 0.2282
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0014 0.017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0389
Brugia malayi nuclear receptor RXR 0.0016 0.0036 0.0074
Leishmania major hypothetical protein, conserved 0.0079 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Plasmodium vivax subtilisin-like protease 1 0.0025 0.0099 0.1763
Brugia malayi CXXC zinc finger family protein 0.0028 0.0125 0.0286
Brugia malayi hypothetical protein 0.0014 0.0023 0.0043
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0017 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0498 1
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0247 0.4828
Echinococcus granulosus allatostatin A receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0785 0.1873
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0581 0.1599
Echinococcus granulosus lamin 0.0025 0.0098 0.0098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0452 0.1077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0233 0.1645 0.3926
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.016 0.1098 0.262
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Brugia malayi proprotein convertase 2 0.0362 0.2601 0.6205
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0143 0.0339
Onchocerca volvulus 0.0014 0.0023 0.0115
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0023 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Schistosoma mansoni biogenic amine receptor 0.0056 0.0334 0.0334
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Onchocerca volvulus 0.0079 0.0498 0.314
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0057 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0247 0.0579
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0036 0.0036
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0099 0.0099
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0017 0.0077
Loa Loa (eye worm) trypsin family protein 0.0012 0.0005 0.001
Schistosoma mansoni biogenic amine receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) TK/EPH protein kinase 0.0159 0.1096 0.2615
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Mycobacterium ulcerans hypothetical protein 0.0045 0.0247 0.4915
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.1104
Echinococcus granulosus tubulin subunit beta 0.0044 0.0245 0.0244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0225 0.0526
Echinococcus granulosus membrane bound transcription factor site 1 0.0025 0.0099 0.0099
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0084
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0023
Plasmodium vivax SET domain protein, putative 0.0029 0.0129 0.239
Schistosoma mansoni opsin-like receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) latrophilin receptor protein 2 0.0074 0.0463 0.1104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Loa Loa (eye worm) hypothetical protein 0.0049 0.028 0.0667
Toxoplasma gondii beta-tubulin, putative 0.0044 0.0245 0.4773
Leishmania major hypothetical protein, conserved 0.0026 0.011 0.2001
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0014 0.002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0334 0.0796
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0143 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Trichomonas vaginalis set domain proteins, putative 0.0224 0.1575 0.6246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0577 0.4189 0.4188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0143 0.0143
Echinococcus granulosus lamin dm0 0.0025 0.0098 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0056 0.0334 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0143 0.0329
Plasmodium falciparum phd finger protein, putative 0.0029 0.0128 0.4973
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0014 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0334 0.0334
Brugia malayi RNA binding protein 0.0072 0.0452 0.1068
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0143 0.0877
Schistosoma mansoni neuropeptide receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0498 0.1371
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0197 0.1374 0.3279
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0498 0.1371
Brugia malayi conserved hypotetical protein 0.0014 0.0023 0.0043
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0334 0.0334
Brugia malayi glutathione reductase 0.0039 0.0208 0.0484
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0334 0.0334
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0143 0.0329
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.001
Echinococcus multilocularis enteropeptidase 0.0012 0.0005 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0098 0.0233
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0112 0.0743 0.2918
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0208 0.0494
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0013 0.0014 0.0037
Brugia malayi neuroendocrine convertase 1 precursor 0.0362 0.2601 0.6205
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0785 0.1873
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0334 0.0334
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Onchocerca volvulus 0.0056 0.0334 0.2096
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0498 0.1938
Echinococcus multilocularis tumor protein p63 0.0335 0.2401 0.2401
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0023 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0014 0.002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.0014 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0056 0.0334 0.2096
Echinococcus granulosus tumor protein p63 0.0335 0.2401 0.2401
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0057
Echinococcus multilocularis Furin 1 0.0136 0.0925 0.0925
Plasmodium vivax acyl-CoA synthetase, putative 0.0033 0.0164 0.31
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0581 0.8844
Onchocerca volvulus 0.0049 0.028 0.1751
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0129 0.239
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0025 0.0099 0.1903
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Trypanosoma brucei trypanothione reductase 0.0039 0.0208 0.2939
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0655 0.1803
Schistosoma mansoni hypothetical protein 0.0102 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi hypothetical protein 0.0026 0.011 0.0252
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0143 0.0143
Onchocerca volvulus 0.0224 0.1575 1
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0247 0.0579
Echinococcus granulosus Furin 1 0.0136 0.0925 0.0925
Giardia lamblia High cysteine membrane protein Group 2 0.0214 0.1504 1
Echinococcus multilocularis microtubule associated protein 2 0.1361 1 1
Echinococcus granulosus furin 0.0577 0.4189 0.4188
Plasmodium falciparum subtilisin-like protease 1 0.0025 0.0099 0.3694
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0334 0.0786
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0334 0.0796
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0452 0.0451
Toxoplasma gondii subtilisin SUB6 0.0025 0.0099 0.1763
Schistosoma mansoni neuropeptide receptor 0.0056 0.0334 0.0334
Brugia malayi follicle stimulating hormone receptor 0.0287 0.2041 0.4866
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0334 0.0334
Onchocerca volvulus 0.0028 0.0125 0.0762
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Onchocerca volvulus 0.0025 0.0098 0.0594
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0498 0.1938
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0334 0.0334
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0014 0.017
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Loa Loa (eye worm) BEN-1 protein 0.0044 0.0245 0.0582
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0014 0.017
Schistosoma mansoni survival motor neuron protein 0.0091 0.059 0.059
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0045 0.0247 0.4915
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0025 0.0099 0.1293
Schistosoma mansoni ephrin receptor 0.0125 0.0844 0.0844
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0143 0.0143
Brugia malayi nuclear hormone receptor 0.0031 0.0143 0.0329
Brugia malayi Pre-SET motif family protein 0.0029 0.0129 0.0297
Mycobacterium ulcerans hypothetical protein 0.0079 0.0498 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Onchocerca volvulus 0.0056 0.0334 0.2096
Brugia malayi hypothetical protein 0.0017 0.0042 0.0087
Loa Loa (eye worm) RNA binding protein 0.0072 0.0452 0.1077
Brugia malayi Serotonin receptor 0.0056 0.0334 0.0786
Brugia malayi MH2 domain containing protein 0.0117 0.0785 0.1865
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0498 0.7552
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0045 0.0247 0.4915
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0334 0.0334
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Echinococcus multilocularis tubulin beta 1 chain 0.0044 0.0245 0.0244
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.4192
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0128 0.0305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0017 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Mycobacterium ulcerans beta-lactamase 0.0079 0.0498 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0044 0.0245 0.0244
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0334 0.0786
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0017 0.0077
Plasmodium vivax tubulin beta chain, putative 0.0044 0.0245 0.4773
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0747 0.0747
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0225 0.0536
Onchocerca volvulus 0.0056 0.0334 0.2096
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0747 0.0747
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0334 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0319 0.6305
Loa Loa (eye worm) hypothetical protein 0.0063 0.0383 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Toxoplasma gondii subtilisin SUB4 0.0025 0.0099 0.1763
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0334 0.0334
Brugia malayi tailless protein 0.0014 0.0023 0.0043
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0351 0.2513 0.2513
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0173 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0036 0.0074
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0025 0.0099 0.1331
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0498 0.0498
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0014 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.2513 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0143 0.0339
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0143 0.0329
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0033 0.0164 0.3217
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0112 0.0743 0.2918
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0581 0.1599
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0334 0.0334
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0143 0.0143
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0017
Loa Loa (eye worm) glutathione reductase 0.0039 0.0208 0.0494
Echinococcus granulosus fmrfamide receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0334 0.0334
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0004 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0581 0.1599
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0143 0.0877
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0005 0.0005
Toxoplasma gondii subtilisin SUB7 0.0025 0.0099 0.1763
Echinococcus granulosus Tubulin beta 2C chain 0.0044 0.0245 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0498 1
Onchocerca volvulus 0.0056 0.0334 0.2096
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Brugia malayi ephrin receptor 1 precursor 0.006 0.0359 0.0846
Loa Loa (eye worm) tubulin beta-4 chain 0.0044 0.0245 0.0582
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Schistosoma mansoni hypothetical protein 0.016 0.1098 0.1098
Echinococcus granulosus g protein coupled receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0143 0.0339
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Loa Loa (eye worm) BEN-1 protein 0.0044 0.0245 0.0582
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0262
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.0014 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Mycobacterium tuberculosis Probable reductase 0.009 0.0581 0.1599
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0354 0.0844
Loa Loa (eye worm) hypothetical protein 0.0031 0.0143 0.0339
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0045 0.0247 0.0681
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0017 0.0048
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0013 0.0014 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0143 0.0143
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0014 0.017
Brugia malayi GnHR receptor homolog 0.0528 0.3831 0.9145
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0137 0.0136
Onchocerca volvulus 0.0013 0.0014 0.0053
Brugia malayi putative neuropeptide receptor 0.0056 0.0334 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0334 0.0334
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.2001
Onchocerca volvulus 0.0031 0.0143 0.0877
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0143 0.0339
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0045 0.0247 0.4915
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0023 0.0023
Schistosoma mansoni zinc finger protein 0.0014 0.0023 0.0023
Leishmania major trypanothione reductase 0.0039 0.0208 0.4007
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0044 0.0245 0.0244
Trypanosoma brucei beta tubulin 0.0044 0.0245 0.3501
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0036 0.0036
Toxoplasma gondii subtilisin SUB5 0.0025 0.0099 0.1763
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0025 0.0099 0.1331
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0143 0.0143
Schistosoma mansoni neuropeptide receptor 0.0056 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus multilocularis lamin dm0 0.0025 0.0098 0.0098
Brugia malayi Dopamine receptor protein 2 0.0056 0.0334 0.0786
Brugia malayi neuropeptide F receptor 0.0056 0.0334 0.0786
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0351 0.2513 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0247 0.4915
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0143 0.0143
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0334 0.0334
Echinococcus granulosus peregrin 0.0029 0.0128 0.0128
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0334 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0334 0.0334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0077
Onchocerca volvulus 0.0079 0.0498 0.314
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0136 0.0925 0.3648
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0334 0.0334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0208 0.0572
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Giardia lamblia Furin precursor putative serine protease 0.0112 0.0743 0.488
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0143 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0125 0.0296
Echinococcus granulosus g protein coupled receptor 0.0056 0.0334 0.0334
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0023
Trichomonas vaginalis tubulin alpha chain, putative 0.0044 0.0245 0.0925
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0334 0.0796
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0334 0.0796
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.003
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0023 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0004 0.0004
Toxoplasma gondii subtilisin SUB10 0.0025 0.0099 0.1763
Treponema pallidum NADH oxidase 0.0014 0.0017 0.5
Brugia malayi G-protein coupled receptor 0.0056 0.0334 0.0786
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0498 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0143 0.0329
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0005 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0005 0.0005
Brugia malayi endoprotease bli-4 precursor 0.0577 0.4189 1
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0307
Echinococcus granulosus beta tubulin 0.0044 0.0245 0.0244
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0247 0.4828
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0023 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0017 0.0246
Echinococcus multilocularis 0.0465 0.3362 0.3362
Schistosoma mansoni opsin-like receptor 0.0056 0.0334 0.0334
Plasmodium falciparum tubulin beta chain 0.0044 0.0245 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0247 0.3189
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0143 0.0143
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0013 0.0014 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0143 0.0329
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0334 0.0786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Plasmodium falciparum thioredoxin reductase 0.0039 0.0208 0.8396
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0143 0.0329
Echinococcus granulosus transmembrane protease serine 3 0.0012 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0233 0.1645 0.392
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0025 0.0099 0.0099
Echinococcus granulosus Tubulin beta 2C chain 0.0044 0.0245 0.0244
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0099 0.0342
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0334 0.0786
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis tubulin epsilon chain, putative 0.0044 0.0245 0.0925
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Echinococcus multilocularis serotonin receptor 0.0056 0.0334 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0143 0.0329
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0098 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0743 0.2918
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.0014 0.017
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0079 0.0498 0.1178
Mycobacterium leprae Possible secreted protease 0.0025 0.0099 0.1331
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0025 0.0099 0.1763
Plasmodium falciparum glutathione reductase 0.0014 0.0017 0.0162
Mycobacterium leprae Probable lipase LipE 0.0079 0.0498 0.7552
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0334 0.0334
Echinococcus multilocularis geminin 0.0319 0.2282 0.2282
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Schistosoma mansoni opsin-like receptor 0.0056 0.0334 0.0334
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0017 0.0077
Schistosoma mansoni lamin 0.0025 0.0098 0.0098
Echinococcus granulosus intermediate filament protein 0.0025 0.0098 0.0098
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0143 0.0143
Brugia malayi hypothetical protein 0.0112 0.0747 0.1773
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0351 0.2513 0.2513
Echinococcus multilocularis Tubulin beta 2C chain 0.0044 0.0245 0.0244
Brugia malayi TAR-binding protein 0.0072 0.0452 0.1068
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0023 0.0043
Echinococcus multilocularis neuroendocrine convertase 2 0.0362 0.2601 0.2601
Brugia malayi hypothetical protein 0.0016 0.0036 0.0074
Plasmodium vivax glutathione reductase, putative 0.0039 0.0208 0.4007
Schistosoma mansoni tubulin subunit beta 0.0044 0.0245 0.0244
Mycobacterium ulcerans lipase LipD 0.0079 0.0498 1
Echinococcus granulosus hypothetical protein 0.0056 0.0334 0.0334
Echinococcus multilocularis sex peptide receptor 0.0056 0.0334 0.0334
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0498 0.7335
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0036 0.0036
Toxoplasma gondii thioredoxin reductase 0.0039 0.0208 0.4007
Plasmodium falciparum subtilisin-like protease 3 0.0025 0.0099 0.3694
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0143 0.0143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0498 1
Schistosoma mansoni coup transcription factor 0.0031 0.0143 0.0143
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0247 0.3646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0014 0.0037
Brugia malayi hypothetical protein 0.0056 0.0334 0.0786
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0014 0.002
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0025 0.0099 0.0224
Loa Loa (eye worm) hypothetical protein 0.0446 0.3218 0.7683
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0246
Loa Loa (eye worm) hypothetical protein 0.0079 0.0498 0.1187
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0025 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0796
Brugia malayi Bromodomain containing protein 0.0029 0.0128 0.0295
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0143 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0143 0.0143
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Onchocerca volvulus 0.0029 0.0129 0.0791
Brugia malayi nuclear receptor RXR 0.0014 0.0023 0.0043
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0334 0.0334
Trichomonas vaginalis tubulin, putative 0.0044 0.0245 0.0925
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0023 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.4192
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0017 0.0162
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0143 0.0339
Leishmania major beta tubulin 0.0044 0.0245 0.4773
Echinococcus multilocularis beta tubulin 0.0044 0.0245 0.0244
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0143 0.0143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0334 0.0334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0074 0.0463 0.0463
Leishmania major subtilisin-like serine peptidase 0.0025 0.0099 0.1763
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0452 0.1077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Onchocerca volvulus 0.0056 0.0334 0.2096
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0128 0.0128
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0334 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0225 0.0225
Echinococcus granulosus tubulin beta 1 chain 0.0044 0.0245 0.0244
Schistosoma mansoni furin-1 (S08 family) 0.0251 0.1775 0.1774
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.028 0.028
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.011 0.1467
Brugia malayi PHD-finger family protein 0.0029 0.0128 0.0295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0099 0.0342
Schistosoma mansoni hypothetical protein 0.0802 0.5857 0.5857

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 20 uM Inhibition of Epidermal growth factor receptor autophosphorylation. ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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