Detailed information for compound 1221964

Basic information

Technical information
  • TDR Targets ID: 1221964
  • Name: N-tert-butyl-2-(4-ethylphenoxy)acetamide
  • MW: 235.322 | Formula: C14H21NO2
  • H donors: 1 H acceptors: 1 LogP: 3.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)OCC(=O)NC(C)(C)C
  • InChi: 1S/C14H21NO2/c1-5-11-6-8-12(9-7-11)17-10-13(16)15-14(2,3)4/h6-9H,5,10H2,1-4H3,(H,15,16)
  • InChiKey: HNCAMMDXUMSIQX-UHFFFAOYSA-N  


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Synonyms

  • N-tert-butyl-2-(4-ethylphenoxy)ethanamide
  • MLS000662871
  • STK205322
  • SMR000270307
  • ZINC00317512
  • Oprea1_569684
  • N-(tert-butyl)-2-(4-ethylphenoxy)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0017 0.0641
Schistosoma mansoni intermediate filament proteins 0.0058 0.0089 0.0561
Echinococcus granulosus neuropeptide receptor 0.0487 0.0948 0.6054
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0192 0.1282
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0093 0.4687
Trichomonas vaginalis esterase, putative 0.011 0.0192 0.1738
Plasmodium falciparum thioredoxin reductase 0.0034 0.004 0.2129
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0015 0.0018
Mycobacterium ulcerans glutaminase 0.0533 0.1041 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.2669
Toxoplasma gondii exonuclease III APE 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0756 0.1489 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0003 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0039 0.0038
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.0424 0.3052
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Plasmodium falciparum thioredoxin reductase 0.0099 0.017 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0005 0.0005
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0038
Echinococcus granulosus tar DNA binding protein 0.0397 0.0769 0.4906
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.004 0.7193
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0051 0.0322
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.0769 0.516
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0075 0.0475
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Onchocerca volvulus 0.0058 0.0089 0.3001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0192 0.1358
Brugia malayi RNA binding protein 0.0397 0.0769 0.516
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0029 0.0627
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0192 1
Echinococcus granulosus intermediate filament protein 0.0058 0.0089 0.0561
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.0454 0.3049
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.059
Schistosoma mansoni smad 0.0052 0.0075 0.0475
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.0454 0.3049
Brugia malayi steroid hormone receptor 0.0034 0.0039 0.0258
Loa Loa (eye worm) nuclear factor I 0.0028 0.0029 0.0189
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0017 0.0641
Echinococcus multilocularis muscleblind protein 0.018 0.0334 0.0333
Brugia malayi TAR-binding protein 0.0397 0.0769 0.516
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis dnaJ subfamily B 0.0794 0.1566 0.1565
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0039 0.0246
Brugia malayi isocitrate dehydrogenase 0.0017 0.0005 0.0031
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0003 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Echinococcus multilocularis musashi 0.0058 0.0089 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0022 0.0144
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.09
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.048 0.0479
Onchocerca volvulus 0.011 0.0192 0.6518
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.004 0.0266
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0007 0.0042
Echinococcus multilocularis lamin 0.0058 0.0089 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0093 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Echinococcus granulosus geminin 0.054 0.1055 0.6738
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0039 0.0246
Loa Loa (eye worm) beta-lactamase 0.011 0.0192 0.1282
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Brugia malayi nuclear receptor NHR-67 0.0016 0.0003 0.0019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0029 0.0159
Trypanosoma brucei unspecified product 0.002 0.0013 0.0666
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0018 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0725
Loa Loa (eye worm) glutathione reductase 0.0099 0.017 0.1137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0018 0.0017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.004 0.0268
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.005
Plasmodium vivax glutathione reductase, putative 0.0099 0.017 0.8837
Echinococcus multilocularis G protein coupled receptor 139 0.0487 0.0948 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0028 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.015 0.0273 0.1743
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0184
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0018
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.017 0.8837
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.016 0.0293 0.1967
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0273 0.1743
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0093 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0018 0.0586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0003 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0039 0.0038
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0192 0.1738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.1082
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0039 0.0258
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Echinococcus granulosus lamin dm0 0.0058 0.0089 0.0561
Mycobacterium ulcerans beta-lactamase 0.011 0.0192 0.1738
Echinococcus multilocularis dna polymerase kappa 0.002 0.0013 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Echinococcus granulosus lamin 0.0058 0.0089 0.0561
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0005 0.0005
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0018 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.029 0.0289
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.0159
Echinococcus granulosus smad 0.0052 0.0075 0.0475
Brugia malayi hypothetical protein 0.016 0.0293 0.1967
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0055 0.0408
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.004 0.1882
Brugia malayi Smad1 0.0052 0.0075 0.0499
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0038
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0192 0.1358
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0093 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0006 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Onchocerca volvulus 0.0016 0.0003 0.0095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.0599 0.4018
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0254 0.1703
Echinococcus multilocularis lamin dm0 0.0058 0.0089 0.0088
Echinococcus granulosus muscleblind protein 0.018 0.0334 0.2127
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0084 0.0557
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.004 0.1882
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0171 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Onchocerca volvulus 0.0034 0.0039 0.1313
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Mycobacterium leprae conserved hypothetical protein 0.011 0.0192 0.3649
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.0599 0.4018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0005 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0214 0.04 0.2685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.017 0.1137
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0005 0.0029
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni neuropeptide receptor 0.0487 0.0948 0.6054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0055 0.0345
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.004 0.1882
Schistosoma mansoni zinc finger protein 0.0016 0.0003 0.0018
Echinococcus granulosus dna polymerase kappa 0.002 0.0013 0.0077
Onchocerca volvulus 0.0016 0.0003 0.0095
Echinococcus granulosus microtubule associated protein 2 0.0668 0.1313 0.8385
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0209 0.1331
Onchocerca volvulus 0.011 0.0192 0.6518
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Echinococcus multilocularis muscleblind protein 1 0.018 0.0334 0.0333
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0003 0.0003
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Leishmania major trypanothione reductase 0.0099 0.017 0.8837
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0192 0.1358
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0093 0.0587
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0017 0.0106
Echinococcus multilocularis smad 0.0052 0.0075 0.0074
Onchocerca volvulus 0.0058 0.0089 0.3001
Brugia malayi glutaminase DH11.1 0.0533 0.1041 0.6992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0039 0.0258
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0017 0.1167
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0222 0.0222
Loa Loa (eye worm) Smad1 0.0052 0.0075 0.0499
Brugia malayi nuclear receptor NHR-88 0.0016 0.0003 0.0019
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0003 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0273 0.1743
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0273 0.0273
Onchocerca volvulus 0.0056 0.0084 0.2831
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.0474 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0192 0.1738
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.0174
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0015 0.0068
Brugia malayi Muscleblind-like protein 0.018 0.0334 0.2237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0075 0.0499
Brugia malayi latrophilin 2 splice variant baaae 0.0214 0.04 0.2685
Schistosoma mansoni survival motor neuron protein 0.0052 0.0075 0.0477
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.004 0.1882
Mycobacterium tuberculosis Probable reductase 0.0225 0.0424 0.3052
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0192 0.1358
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Trichomonas vaginalis glutaminase, putative 0.0533 0.1041 1
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Brugia malayi CXXC zinc finger family protein 0.0056 0.0084 0.0557
Plasmodium falciparum glutathione reductase 0.0099 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.0474 0.342
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0017 0.0087
Loa Loa (eye worm) acetyltransferase 0.0141 0.0254 0.1703
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.017 0.1138
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0051 0.1471
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.0424 0.3052
Brugia malayi hypothetical protein 0.015 0.0273 0.1833
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0576
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Loa Loa (eye worm) RNA binding protein 0.0397 0.0769 0.516
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0028 0.0175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0029
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.1313 0.8385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0192 0.1358
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Schistosoma mansoni smad 0.0023 0.0018 0.011
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0039 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Brugia malayi hypothetical protein 0.0253 0.048 0.3219
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0246 0.1568
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0192 0.1219
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Schistosoma mansoni hypothetical protein 0.0794 0.1566 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106
Toxoplasma gondii thioredoxin reductase 0.0099 0.017 0.0228
Brugia malayi beta-lactamase 0.011 0.0192 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.048 0.3061
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Plasmodium falciparum glutathione reductase 0.0034 0.004 0.2129
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0254 0.1619
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.017 0.12
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.004 0.0268
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Echinococcus multilocularis dna polymerase eta 0.002 0.0013 0.0012
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0015 0.0499
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0013 0.0077
Brugia malayi nuclear receptor NHR-88 0.0034 0.0039 0.0258
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0055 0.0068
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0039 0.0246
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0003 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0039 0.1313
Brugia malayi conserved hypotetical protein 0.0016 0.0003 0.0019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.004 0.1882
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.004 0.0048
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0013 0.0054
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0115
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0017 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0013 0.0666
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0246
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0015 0.0564
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0125 0.0222 0.1416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus multilocularis GPCR, family 2 0.0099 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Brugia malayi intermediate filament protein 0.0058 0.0089 0.059
Loa Loa (eye worm) DR-78 0.0016 0.0003 0.0019
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Loa Loa (eye worm) glutaminase 2 0.0533 0.1041 0.6992
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.004 0.2106
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.0169
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Brugia malayi nuclear receptor RXR 0.0018 0.0007 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.0769 0.516
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0039 0.0246
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.017 0.8837
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0018 0.011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0003 0.0019
Schistosoma mansoni coup transcription factor 0.0034 0.0039 0.0246
Brugia malayi tailless protein 0.0016 0.0003 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.0641
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.0474 0.342
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Leishmania major DNA polymerase eta, putative 0.002 0.0013 0.04
Toxoplasma gondii ABC1 family protein 0.011 0.0192 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.0322
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0039 0.0246
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.0322
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0048 0.1344
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0006 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0189
Schistosoma mansoni DNA polymerase eta 0.002 0.0013 0.0077
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0048 0.9136
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0089 0.059
Brugia malayi MH2 domain containing protein 0.0023 0.0018 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Trypanosoma brucei trypanothione reductase 0.0099 0.017 0.8869
Brugia malayi Latrophilin receptor protein 2 0.0099 0.017 0.1138
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0003 0.0018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0171 0.017
Mycobacterium ulcerans hypothetical protein 0.011 0.0192 0.1738
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0013 0.0054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0075 0.0501
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0192 0.0191
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0013 0.04
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0013 0.04
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.004 1
Echinococcus multilocularis neuropeptide receptor 0.0487 0.0948 0.0948
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0246
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0075 0.0475
Mycobacterium ulcerans lipase LipD 0.011 0.0192 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0051 0.0322
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.1313 0.1313
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Mycobacterium leprae Probable lipase LipE 0.011 0.0192 0.3649
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.0599 0.4018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.004 0.2106
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0022 0.0144
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.0424 0.3052
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0003 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0003 0.0003
Onchocerca volvulus 0.011 0.0192 0.6518
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.3619 0.7236 1
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0039 0.0258
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.004 0.2129
Echinococcus granulosus dnaJ subfamily B 0.0794 0.1566 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Brugia malayi ecdysone receptor 0.0016 0.0003 0.0019
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0055 0.2653
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Brugia malayi glutathione reductase 0.0099 0.017 0.1137
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.0159
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0192 0.1358
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0055 0.0408
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0246
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0051 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Brugia malayi nuclear hormone receptor 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Loa Loa (eye worm) glutaminase 0.0533 0.1041 0.6992
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0007 0.0042
Leishmania major hypothetical protein, conserved 0.011 0.0192 1
Echinococcus multilocularis tar DNA binding protein 0.0397 0.0769 0.0768
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0039 0.0246
Echinococcus granulosus dna polymerase eta 0.002 0.0013 0.0077
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0029 0.0174
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.004 0.0268
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0039 0.0246
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0048 0.2582
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0075 0.0499
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Schistosoma mansoni hypothetical protein 0.0214 0.04 0.2553
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.004 0.0268
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0039 0.0246
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0051 0.246
Loa Loa (eye worm) hypothetical protein 0.0312 0.0599 0.4018
Echinococcus granulosus cpg binding protein 0.0059 0.009 0.057
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.0424 0.3052
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Loa Loa (eye worm) hypothetical protein 0.0253 0.048 0.3219
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0222 0.1416
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0254 0.0253
Onchocerca volvulus 0.0052 0.0075 0.2548
Schistosoma mansoni hypothetical protein 0.0052 0.0075 0.0477
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.004 0.0048
Brugia malayi ecdysteroid receptor 0.0034 0.0039 0.0258
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0051 0.005
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0075 0.0475
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0018 0.011
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus multilocularis geminin 0.054 0.1055 0.1055
Leishmania major DNA polymerase kappa, putative 0.002 0.0013 0.04
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0192 0.1282
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0018 0.0115
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Brugia malayi MH2 domain containing protein 0.0756 0.1489 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0075 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0039 0.1313
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.0424 0.3052
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0039 0.0246
Echinococcus multilocularis cpg binding protein 0.0059 0.009 0.0089
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.004 0.2129
Brugia malayi Thioredoxin reductase 0.0099 0.017 0.1137
Echinococcus granulosus Smad4 0.0052 0.0075 0.0475
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.1377 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0039 0.0246
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.1082
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0055 0.0068
Onchocerca volvulus 0.0029 0.0029 0.097
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.0474 0.342
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.004 0.0256
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0225 0.0424 0.8867
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0081
Schistosoma mansoni Smad4 0.0052 0.0075 0.0475
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0051 0.0322
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0039 0.0246
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Onchocerca volvulus 0.016 0.0293 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0039 0.0258
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.004 0.0268
Loa Loa (eye worm) MH2 domain-containing protein 0.0756 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Loa Loa (eye worm) TAR-binding protein 0.0397 0.0769 0.516
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0191 0.0256
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0018 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Schistosoma mansoni glutaminase 0.0533 0.1041 0.6649
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0051 0.0373
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Brugia malayi nuclear hormone receptor 0.0034 0.0039 0.0258
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0005 0.0277
Schistosoma mansoni cpg binding protein 0.0056 0.0084 0.053
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0017 0.0172
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0039 0.0246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0246
Plasmodium vivax hypothetical protein, conserved 0.011 0.0192 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.017 0.1138
Echinococcus multilocularis Smad4 0.0052 0.0075 0.0074
Echinococcus granulosus GPCR family 2 0.0099 0.017 0.1082
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0003 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0013 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0051 1
Treponema pallidum NADH oxidase 0.0034 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0075 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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