Detailed information for compound 1265134

Basic information

Technical information
  • TDR Targets ID: 1265134
  • Name: 3-methoxy-N-[3-[5-methyl-1-[2-(trifluoromethy l)phenyl]triazol-4-yl]-1,2,4-thiadiazol-5-yl] benzamide
  • MW: 460.432 | Formula: C20H15F3N6O2S
  • H donors: 1 H acceptors: 5 LogP: 4.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)Nc1snc(n1)c1nnn(c1C)c1ccccc1C(F)(F)F
  • InChi: 1S/C20H15F3N6O2S/c1-11-16(26-28-29(11)15-9-4-3-8-14(15)20(21,22)23)17-24-19(32-27-17)25-18(30)12-6-5-7-13(10-12)31-2/h3-10H,1-2H3,(H,24,25,27,30)
  • InChiKey: XUDSCXNFRSWGJM-UHFFFAOYSA-N  


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Synonyms

  • 3-methoxy-N-[3-[5-methyl-1-[2-(trifluoromethyl)phenyl]-4-triazolyl]-1,2,4-thiadiazol-5-yl]benzamide
  • 3-methoxy-N-[3-[5-methyl-1-[2-(trifluoromethyl)phenyl]-1,2,3-triazol-4-yl]-1,2,4-thiadiazol-5-yl]benzamide
  • G193-0640
  • NCGC00128751-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0097 0.0238
Loa Loa (eye worm) hypothetical protein 0.0046 0.0353 0.0995
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0108 0.1111 0.3217
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0097 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0097 0.0084
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0444 0.0431
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0307 0.3545 0.3537
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0444 0.0431
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0441 0.0428
Plasmodium vivax unspecified product 0.0019 0.0022 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0306 0.0856
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0377
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0747 0.668
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0097 0.0084
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2098 0.2088
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0444 0.1221
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0134 0.0121
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0097 0.0084
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Brugia malayi Cathepsin L-like cysteine proteinase 0.0046 0.0353 0.0963
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0247 0.0235
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0362 0.035
Giardia lamblia Hypothetical protein 0.0019 0.0022 0.0075
Mycobacterium ulcerans hypothetical protein 0.0156 0.1704 1
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0029 0.0263
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0124 0.1311 0.1299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Leishmania major cathepsin L-like protease 0.0065 0.0578 0.1655
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.0426 0.1203
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0138 0.0735
Brugia malayi hypothetical protein 0.0025 0.0097 0.0238
Brugia malayi cathepsin L precursor 0.0019 0.0022 0.0026
Onchocerca volvulus 0.0065 0.0578 0.6219
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0444 0.0432
Brugia malayi nuclear receptor RXR 0.0025 0.0097 0.0238
Schistosoma mansoni chromobox protein 0.0069 0.0635 0.0624
Onchocerca volvulus 0.0065 0.0578 0.6219
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0444 0.1221
Loa Loa (eye worm) X11 protein 0.0068 0.0615 0.1734
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Echinococcus multilocularis cathepsin b 0.0307 0.3545 0.3537
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0022 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0298 0.2596
Entamoeba histolytica ABC transporter, putative 0.0029 0.0146 0.234
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0022 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0097 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0444 0.1221
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0444 0.4714
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0097 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0733 0.2041
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0019 0.0022 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Loa Loa (eye worm) hypothetical protein 0.0307 0.3545 1
Brugia malayi steroid hormone receptor 0.0054 0.0444 0.1221
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0085 0.0824 0.0812
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0444 0.1221
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0097 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Entamoeba histolytica hypothetical protein 0.0023 0.0069 0.0976
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0747 0.2149
Onchocerca volvulus 0.0047 0.0362 0.3799
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1502 0.1491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0134 0.0354
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0022 0.0009
Entamoeba histolytica cysteine proteinase 2 0.0038 0.0247 0.4141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0013 0.0003
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0019 0.0022 0.0164
Trypanosoma cruzi cysteine peptidase, putative 0.016 0.1742 0.4896
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0545 0.0533
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0138 0.0354
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0134 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0747 0.2079
Echinococcus multilocularis GPCR, family 2 0.0035 0.0212 0.0199
Brugia malayi Common central domain of tyrosinase family protein 0.0092 0.0917 0.256
Leishmania major GTP-binding protein, putative 0.0021 0.0043 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0212 0.0566
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0022 0.0146
Loa Loa (eye worm) hypothetical protein 0.0065 0.0582 0.1642
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0444 0.1221
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0506 0.1443
Onchocerca volvulus 0.0092 0.0917 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0578 0.1602
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0262 0.2267
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0444 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0138 0.0364
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.0426 0.0414
Echinococcus multilocularis chromobox protein 1 0.0069 0.0635 0.0623
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0092 0.0917 0.256
Toxoplasma gondii hypothetical protein 0.0048 0.0374 0.3364
Onchocerca volvulus 0.0065 0.0578 0.6219
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.0667 0.1916
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0444 0.0432
Brugia malayi Importin beta-1 subunit 0.0028 0.0134 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3427 0.9665
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.0578 0.0567
Echinococcus multilocularis chromobox protein 1 0.0069 0.0635 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0022 0.0009
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2098 0.2088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0444 0.1251
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.02
Toxoplasma gondii cathepsin CPC1 0.0019 0.0022 0.0195
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0001
Entamoeba histolytica cysteine protease, putative 0.0065 0.0578 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0101 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Onchocerca volvulus 0.0025 0.0097 0.0837
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0043 0.0029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3497 0.9864
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0083
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0013 0.5
Brugia malayi conserved hypotetical protein 0.0025 0.0097 0.0238
Schistosoma mansoni hypothetical protein 0.0081 0.0785 0.0773
Trypanosoma brucei ABC transporter, putative 0.0029 0.0146 0.0387
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0049 0.0628
Brugia malayi cathepsin L-like precursor 0.0046 0.0353 0.0963
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0212 0.0599
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0747 0.2079
Onchocerca volvulus 0.0065 0.0578 0.6219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0444 0.1251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Plasmodium falciparum serine repeat antigen 3 0.0019 0.0022 0.0146
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Onchocerca volvulus Cathepsin F homolog 0.0065 0.0578 0.6219
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0444 0.1221
Brugia malayi ABC transporter family protein 0.0025 0.0091 0.0223
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0029 0.0146 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Schistosoma mansoni nuclear receptor 0.0025 0.0097 0.0084
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0134 0.0377
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0029 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0635 0.5663
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0085
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0292 0.263
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0426 0.2443
Giardia lamblia Cysteine protease 0.0019 0.0022 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0545 0.0533
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0785 0.0773
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0785 0.0773
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0049 0.0645
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0578 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0306 0.2752
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0307 0.3545 0.3537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0247 0.213
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0092 0.0908 0.2536
Mycobacterium ulcerans hypothetical protein 0.0029 0.0138 0.0735
Leishmania major DNA polymerase eta, putative 0.0077 0.0733 0.2109
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0095 0.0945 0.264
Plasmodium vivax vivapain-2 0.0065 0.0578 1
Schistosoma mansoni ran 0.0021 0.0043 0.003
Loa Loa (eye worm) cysteine protease 0.0065 0.0578 0.1631
Loa Loa (eye worm) RNA binding protein 0.0062 0.0545 0.1536
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0026 0.0104 0.0294
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0545 0.1536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.0578 0.0566
Echinococcus granulosus cathepsin L 0.0019 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.0917 0.256
Echinococcus granulosus metabotropic glutamate receptor 5 0.0124 0.1311 0.1299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1111 0.11
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0097 0.0083
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0095 0.0945 0.0933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.0085
Giardia lamblia Hypothetical protein 0.0019 0.0022 0.0075
Plasmodium falciparum cysteine proteinase falcipain 1 0.0038 0.0247 0.4141
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0134 0.0121
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0013 0.0038
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0785 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0353 0.3089
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.006 0.0519 0.1463
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0134 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Onchocerca volvulus 0.0065 0.0578 0.6219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0379
Echinococcus granulosus tar DNA binding protein 0.0062 0.0545 0.0532
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0444 0.0432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0444 0.1251
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.1185 0.332
Plasmodium falciparum ABC transporter G family member 2 0.0029 0.0146 0.234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0444 0.1251
Giardia lamblia Cathepsin B precursor 0.0019 0.0022 0.0075
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0065 0.0578 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0019 0.0022 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0138
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0306 0.2663
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.0578 0.0566
Plasmodium vivax unspecified product 0.0038 0.0247 0.4152
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.0426 0.0414
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0545 0.1507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0049 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0444 0.0431
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0545 0.1536
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0022 0.0026
Giardia lamblia DINP protein human, muc B family 0.0059 0.0506 0.4486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Schistosoma mansoni hypothetical protein 0.0024 0.0086 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0444 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0307 0.0861
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) ABC transporter 0.0025 0.0091 0.0257
Plasmodium falciparum serine repeat antigen 9 0.0019 0.0022 0.0146
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.0917 0.256
Giardia lamblia Cysteine protease 0.0019 0.0022 0.0075
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0019 0.0022 0.0026
Schistosoma mansoni importin beta-1 0.0028 0.0134 0.0122
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0022 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0444 0.0432
Loa Loa (eye worm) glutamate receptor 0.004 0.0274 0.0772
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0097 0.0837
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0733 0.2041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Echinococcus granulosus importin subunit beta 1 0.0028 0.0134 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0444 0.0432
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0138 0.0354
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0298 0.3093
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0444 0.1221
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0019 0.0022 0.0061
Giardia lamblia Cathepsin B precursor 0.0019 0.0022 0.0075
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0029 0.0146 0.0133
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0029 0.0146 0.131
Brugia malayi ecdysone receptor 0.0025 0.0097 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0247 0.213
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0097 0.0238
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0444 0.0432
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0441 0.0428
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0299 0.0835
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0101 0.0087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0377
Loa Loa (eye worm) hypothetical protein 0.0053 0.0441 0.1245
Loa Loa (eye worm) hypothetical protein 0.0124 0.1311 0.3698
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0138
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0013 0.0018
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0101 0.0284
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0362 0.0349
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0362 0.0349
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0138 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0444 0.1221
Giardia lamblia Cathepsin B precursor 0.0019 0.0022 0.0075
Schistosoma mansoni ap endonuclease 0.0018 0.0013 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0444 0.1221
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3427 0.9665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Loa Loa (eye worm) hypothetical protein 0.0065 0.0578 0.1631
Schistosoma mansoni hypothetical protein 0.0081 0.0785 0.0773
Brugia malayi RNA binding protein 0.0062 0.0545 0.1507
Entamoeba histolytica cysteine proteinase 1, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) calcium channel 0.0095 0.0945 0.2666
Brugia malayi cathepsin B-like cysteine proteinase 0.0307 0.3545 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0092 0.0917 0.2586
Leishmania major cathepsin L-like protease 0.016 0.1742 0.5064
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0022 0.0164
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0101 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0022 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0747 0.4338
Brugia malayi fibroinase precursor 0.0019 0.0022 0.0026
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0785 0.0773
Echinococcus granulosus cathepsin L cysteine proteinase 0.0065 0.0578 0.0566
Trypanosoma cruzi cysteine protease, putative 0.0038 0.0247 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0247 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0019 0.0022 0.0075
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0444 0.0431
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0138 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.02
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0019 0.0022 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0306 0.0856
Schistosoma mansoni metabotropic glutamate receptor 0.0049 0.039 0.0378
Echinococcus granulosus cathepsin l cysteine peptidase 0.0065 0.0578 0.0566
Brugia malayi TAR-binding protein 0.0062 0.0545 0.1507
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0263 0.2269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0444 0.1221
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0635 0.1792
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0138 0.2199
Schistosoma mansoni hypothetical protein 0.0075 0.0706 0.0695
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0097 0.0272
Plasmodium falciparum serine repeat antigen 5 0.0019 0.0022 0.0146
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0097 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0706 0.1964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Onchocerca volvulus 0.0092 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0138
Echinococcus granulosus GPCR family 2 0.0035 0.0212 0.0199
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.0022 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0247 0.0665
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0138 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0444 0.1221
Schistosoma mansoni DNA polymerase eta 0.0077 0.0733 0.0722
Schistosoma mansoni ran 0.0021 0.0043 0.003
Brugia malayi RNA, U transporter 1 0.0081 0.0775 0.2159
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0146 0.0132
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0212 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0146 0.0782
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0519 0.0507
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0095 0.0945 0.0933
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0444 0.0431
Trypanosoma brucei unspecified product 0.0036 0.0228 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Leishmania major cysteine peptidase A (CPA) 0.0065 0.0578 0.1655
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0022 0.0009
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0101 0.1544
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0262 0.2999 0.8455
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0945 0.0933
Toxoplasma gondii preprocathepsin c precursor, putative 0.0019 0.0022 0.0195
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0013 0.5
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0065 0.0583
Loa Loa (eye worm) ShTK domain-containing protein 0.0092 0.0917 0.2586
Echinococcus granulosus cathepsin l1 0.0046 0.0353 0.034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0832 0.9981 0.9981
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0247 0.4141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0022 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0299 0.081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Leishmania major DNA polymerase kappa, putative 0.0059 0.0506 0.1443
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0097 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Brugia malayi nuclear hormone receptor 0.0025 0.0097 0.0238
Plasmodium vivax importin-beta 2, putative 0.0028 0.0134 0.2154
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0019 0.0022 0.0075
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0515
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0247 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0444 0.0432
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0022 0.0061
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0019 0.0022 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0125
Echinococcus granulosus chromobox protein 1 0.0069 0.0635 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0043 0.0532
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Trypanosoma cruzi major cysteine proteinase, putative 0.0019 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0377
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0101 0.025
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0545 0.0533
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0019 0.0022 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0444 0.0431
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0138 0.2199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Echinococcus granulosus dna polymerase eta 0.0077 0.0733 0.0721
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0134 0.1208
Onchocerca volvulus 0.0065 0.0578 0.6219
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0019 0.0022 0.0075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0097 0.0083
Loa Loa (eye worm) DR-78 0.0025 0.0097 0.0272
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0065 0.0578 0.1631
Brugia malayi hypothetical protein 0.0025 0.0097 0.0238
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.012
Echinococcus multilocularis snurportin 1 0.0303 0.3497 0.3488
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0377
Onchocerca volvulus 0.0054 0.0444 0.4714
Echinococcus multilocularis cathepsin L 0.0038 0.0247 0.0234
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0444 0.0431
Schistosoma mansoni cathepsin B (C01 family) 0.0019 0.0022 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.016 0.045
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0278 0.0265
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0038 0.0247 0.0685
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0097 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0022 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.0426 0.7311
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0095 0.0945 0.0933
Brugia malayi hypothetical protein 0.0028 0.0134 0.0343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0444 0.1251
Giardia lamblia Encystation-specific protease 0.0019 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0294
Plasmodium falciparum flap endonuclease 1 0.0026 0.0101 0.1544
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0353 0.6005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0444 0.1221
Echinococcus granulosus flap endonuclease 1 0.0026 0.0101 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0444 0.1221
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0101 0.1559
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0426 0.1172
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0444 0.0431
Brugia malayi nuclear receptor NHR-67 0.0025 0.0097 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0212 0.0199
Echinococcus granulosus cathepsin L 0.0038 0.0247 0.0234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0444 0.0431
Brugia malayi Receptor family ligand binding region containing protein 0.0026 0.0104 0.026
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1554 0.4382
Loa Loa (eye worm) hypothetical protein 0.0092 0.0917 0.2586
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0247 0.0665
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0247 0.0235
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0247 0.4141
Leishmania major importin beta-1 subunit, putative 0.0023 0.0069 0.0162
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0945 0.0933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0444 0.1251
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0123 0.1003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Giardia lamblia Cysteine protease 0.0019 0.0022 0.0075
Trypanosoma brucei cysteine peptidase C (CPC) 0.0108 0.1111 0.3217
Giardia lamblia Cathepsin B precursor 0.0108 0.1111 1
Trypanosoma brucei unspecified product 0.0072 0.0667 0.1916
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0146 0.0132
Brugia malayi hypothetical protein 0.0028 0.0134 0.0343
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0097 0.0272
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0019 0.0022 0.0146
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0069 0.0502
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0444 0.0432
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0019 0.0022 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0747 0.2079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Schistosoma mansoni cathepsin S (C01 family) 0.0019 0.0022 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0292 0.0792
Onchocerca volvulus Cathepsin L homolog 0.0065 0.0578 0.6219
Echinococcus granulosus snurportin 1 0.0303 0.3497 0.3488
Echinococcus multilocularis cysteine protease 0.0065 0.0578 0.0566
Brugia malayi MH2 domain containing protein 0.0144 0.1554 0.4363
Plasmodium falciparum importin beta, putative 0.0028 0.0134 0.214
Brugia malayi metabotropic glutamate receptor type 2 0.0049 0.039 0.107
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0029 0.0146 0.0387
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.0578 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0307 0.3545 0.3537
Giardia lamblia ABC transporter 0.0029 0.014 0.1153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0138 0.0735
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0747 0.0735
Onchocerca volvulus 0.0092 0.0917 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0444 0.0431
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0057 0.0491 0.1356
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.151 0.4383
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0019 0.0022 0.0075
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0097 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0022 0.0075
Trypanosoma brucei ATP-binding cassette protein, putative 0.0029 0.0146 0.0387
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0388
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0097 0.0084
Echinococcus granulosus chromobox protein 1 0.0069 0.0635 0.0623
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0022 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.3427 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0138 0.0735
Loa Loa (eye worm) ctsf protein 0.0065 0.0578 0.1631
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0097 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.151 0.4238
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0545 0.0533
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0635 0.5663
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0095 0.0945 0.0934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0262 0.2267
Loa Loa (eye worm) hypothetical protein 0.0095 0.0945 0.2666
Loa Loa (eye worm) hypothetical protein 0.0092 0.0917 0.2586
Onchocerca volvulus 0.003 0.016 0.1541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Schistosoma mansoni coup transcription factor 0.0054 0.0444 0.0432
Trypanosoma cruzi cysteine peptidase, putative 0.016 0.1742 0.4896
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0306 0.2663
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0263 0.4411
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0307 0.3545 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0138 0.0735
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0362 0.0349
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0141 0.1516 0.4257
Schistosoma mansoni hypothetical protein 0.0081 0.0785 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0022 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0307 0.3545 0.3537
Trypanosoma cruzi ABC transporter, putative 0.0029 0.0146 0.0377
Echinococcus multilocularis cathepsin L cysteine protease 0.0065 0.0578 0.0566
Echinococcus multilocularis dna polymerase eta 0.0077 0.0733 0.0721
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0146 0.0782
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0022 0.0026
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0747 0.4338
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0022 0.0075
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0146 0.0132
Echinococcus multilocularis cathepsin L 0.0019 0.0022 0.0008
Plasmodium vivax vivapain-3 0.0038 0.0247 0.4152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0043 0.0029
Brugia malayi Cathepsin L-like precursor 0.0046 0.0353 0.0963
Loa Loa (eye worm) cathepsin B 0.0108 0.1111 0.3135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0097 0.0083
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0444 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1132 0.3192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0043 0.0383
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.0578 0.0567
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0444 0.0432
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0019 0.0022 0.0009
Onchocerca volvulus 0.0025 0.0097 0.0837
Echinococcus granulosus cathepsin b 0.0307 0.3545 0.3537
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0945 0.0933
Brugia malayi Metabotropic glutamate receptor precursor. 0.0101 0.1025 0.2866
Onchocerca volvulus 0.0065 0.0578 0.6219
Schistosoma mansoni cathepsin C 0.0019 0.0022 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0146 0.0132
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0022 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0444 0.0431
Plasmodium falciparum cysteine proteinase falcipain 3 0.0065 0.0578 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1552 0.1542
Echinococcus multilocularis sodium channel protein 0.004 0.0278 0.0265
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0146 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0138 0.5
Loa Loa (eye worm) glutamate receptor 0.0101 0.1025 0.2891
Loa Loa (eye worm) hypothetical protein 0.0047 0.0362 0.102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.0578 0.5145
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0747 0.2149
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0097 0.0238
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0306 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0247 0.4141
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0057 0.0491 0.14
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0101 0.0794
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0306 0.2752
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0785 0.2214
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0019 0.0022 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0747 0.2079
Brugia malayi mbt repeat family protein 0.0047 0.0362 0.0989
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.02
Giardia lamblia Cysteine protease 0.0019 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.1992
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0506 0.2913
Giardia lamblia Cathepsin L-like protease 0.0019 0.0022 0.0075
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0146 0.0782
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0035
Plasmodium vivax vivapain-1 0.0038 0.0247 0.4152
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0095 0.0945 0.0934
Brugia malayi nuclear receptor NHR-88 0.0025 0.0097 0.0238
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0101 0.0905
Giardia lamblia Cathepsin B precursor 0.0108 0.1111 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0019 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0353 0.3089
Schistosoma mansoni ABC transporter 0.0025 0.0091 0.0079
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.0085
Echinococcus multilocularis amyloid beta A4 protein 0.0068 0.0615 0.0602
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0038 0.0247 0.0665
Schistosoma mansoni tyrosinase precursor 0.0092 0.0917 0.0905
Trypanosoma cruzi cysteine peptidase, putative 0.016 0.1742 0.4896
Plasmodium falciparum serine repeat antigen 4 0.0019 0.0022 0.0146
Onchocerca volvulus Cathepsin L homolog 0.0065 0.0578 0.6219
Loa Loa (eye worm) hypothetical protein 0.0046 0.0353 0.0995
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0138 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0444 0.1221
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0388
Toxoplasma gondii cathepsin CPC2 0.0019 0.0022 0.0195
Onchocerca volvulus 0.0029 0.0138 0.1295
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1554 0.4382
Brugia malayi Flap endonuclease-1 0.0026 0.0101 0.025
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0029 0.0016
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0115 0.1195 0.1184
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0441 0.0429
Plasmodium falciparum serine repeat antigen 8 0.0019 0.0022 0.0146
Brugia malayi Heterochromatin protein 1 0.0069 0.0635 0.1763
Plasmodium falciparum serine repeat antigen 2 0.0019 0.0022 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0444 0.1251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0599
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0097 0.0083
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0247 0.0665
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1552 0.1541
Leishmania major cathepsin L-like protease 0.016 0.1742 0.5064
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0134 0.012
Leishmania major cathepsin L-like protease 0.0065 0.0578 0.1655
Echinococcus granulosus voltage dependent calcium channel 0.0095 0.0945 0.0933
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0019 0.0022 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1111 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0049 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0065 0.0578 0.0566
Onchocerca volvulus 0.006 0.0519 0.5553
Plasmodium falciparum serine repeat antigen 6 0.0019 0.0022 0.0146
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0019 0.0022 0.0146
Giardia lamblia Cathepsin B precursor 0.0108 0.1111 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Schistosoma mansoni tyrosinase precursor 0.0092 0.0917 0.0905
Brugia malayi hypothetical protein 0.0065 0.0582 0.1613
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0441 0.0428
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0441 0.1214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0022 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0299 0.081
Brugia malayi nuclear receptor NHR-88 0.0054 0.0444 0.1221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0035
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0101 0.0255
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0785 0.0773
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0187 0.208 0.2069
Echinococcus granulosus amyloid beta A4 protein 0.0068 0.0615 0.0602
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0444 0.0431
Trypanosoma cruzi cysteine proteinase, putative 0.0038 0.0247 0.0665
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0065 0.0578 0.1631
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0029 0.0146 0.0387
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0049 0.021
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0146 0.0132
Leishmania major cathepsin L-like protease 0.0065 0.0578 0.1655
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0138 0.0364
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0097 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0444 0.1221
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0134 0.0354
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0506 0.1443
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0362 0.0349
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0022 0.0075
Brugia malayi ShTK domain containing protein 0.0092 0.0917 0.256
Toxoplasma gondii cathepsin B 0.0108 0.1111 1
Brugia malayi polk-prov protein 0.0042 0.0306 0.083
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0306 0.5185
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0265
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0069 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Brugia malayi ecdysteroid receptor 0.0054 0.0444 0.1221
Loa Loa (eye worm) hypothetical protein 0.0046 0.0353 0.0995
Loa Loa (eye worm) tyrosinase 1 0.0092 0.0917 0.2586
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0022 0.0009
Loa Loa (eye worm) MBCTL1 0.0053 0.0441 0.1245
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0097 0.0837
Echinococcus granulosus tumor protein p63 0.0408 0.4788 0.4781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0444 0.1251
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0097 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0022 0.0075
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0138 0.0735
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0362 0.035
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0138 0.0354
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0444 0.0431
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0388
Plasmodium vivax serine-repeat antigen (SERA) 0.0019 0.0022 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0945 0.0933
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0298 0.2596
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0065 0.0578 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0019 0.0022 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0134 0.0343
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Echinococcus granulosus dna polymerase kappa 0.0078 0.0747 0.0735
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0097 0.0238
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0362 0.102
Entamoeba histolytica hypothetical protein 0.0019 0.0022 0.0146
Trichomonas vaginalis ran, putative 0.0021 0.0043 0.0265
Onchocerca volvulus 0.0046 0.0353 0.3698
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0353 0.0341
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0444 0.0432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.0426 0.0415
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0747 0.668
Entamoeba histolytica Ran family GTPase 0.0021 0.0043 0.0515
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0441 0.0428
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0545 0.0532
Schistosoma mansoni hypothetical protein 0.0289 0.3328 0.3319
Plasmodium falciparum serine repeat antigen 1 0.0019 0.0022 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0307 0.0861
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0411 0.1127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1704 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0026 0.0104 0.0294
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0444 0.0432
Echinococcus multilocularis cathepsin b 0.0307 0.3545 0.3537
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0013 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0022 0.0075
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0108 0.1111 0.3111
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0022 0.0075
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.0917 0.256
Brugia malayi mbt repeat family protein 0.0047 0.0362 0.0989
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0134 0.0343
Leishmania major DNA polymerase eta, putative 0.0041 0.0292 0.0817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0212 0.0199
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0263 0.4411
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0022 0.0061
Schistosoma mansoni amyloid beta A4 protein related 0.0068 0.0615 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0022 0.0075
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0024 0.0086 0.0427
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.02
Toxoplasma gondii cathepsin CPL 0.0065 0.0578 0.5203
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0019 0.0022 0.0164
Loa Loa (eye worm) hypothetical protein 0.0054 0.0444 0.1251
Schistosoma mansoni metabotropic glutamate receptor 0.0085 0.0824 0.0813
Giardia lamblia Cathepsin B precursor 0.0019 0.0022 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0138 0.0364
Schistosoma mansoni chromobox protein 0.0069 0.0635 0.0624
Loa Loa (eye worm) hypothetical protein 0.0077 0.0733 0.2069
Loa Loa (eye worm) hypothetical protein 0.0039 0.0262 0.074
Giardia lamblia Cathepsin B precursor 0.0019 0.0022 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0444 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0022 0.0075
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0545 0.0533
Brugia malayi nuclear receptor RXR 0.0028 0.0134 0.0343
Leishmania major cathepsin L-like protease 0.016 0.1742 0.5064
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0097 0.0083
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0945 0.0933
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0019 0.0022 0.0075
Loa Loa (eye worm) fibroinase 0.0065 0.0578 0.1631
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0262 0.2689
Brugia malayi cathepsin L-like cysteine proteinase 0.0019 0.0022 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0043 0.0085
Schistosoma mansoni voltage-gated cation channel 0.0095 0.0945 0.0934
Schistosoma mansoni nuclear receptor 0.0025 0.0097 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0444 0.4714
Plasmodium vivax ABC transporter G family member 2, putative 0.0029 0.0146 0.2354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0444 0.0431
Plasmodium vivax vivapain-2 0.0065 0.0578 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.151 0.4383
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0247 0.4141
Brugia malayi Cathepsin L-like precursor 0.0065 0.0578 0.1602
Onchocerca volvulus 0.0092 0.0917 1
Trypanosoma cruzi cruzipain precursor, putative 0.016 0.1742 0.4896
Schistosoma mansoni flap endonuclease-1 0.0023 0.007 0.0058
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.006 0.0527 0.1457
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0247 0.0665
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0444 0.0431
Schistosoma mansoni hypothetical protein 0.0303 0.3497 0.3489
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0299 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0747 0.2149
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0065 0.0578 0.5145
Echinococcus multilocularis tumor protein p63 0.0408 0.4788 0.4781
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0123 0.1003
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0138 0.2199
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0444 0.4714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0125
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.0578 0.5145
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0138
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.3427 1
Echinococcus granulosus cathepsin b 0.0307 0.3545 0.3537
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0019 0.0022 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0785 0.2187
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1552 0.4358
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0444 0.1221
Echinococcus granulosus cysteine protease 0.0038 0.0247 0.0234
Toxoplasma gondii exonuclease III APE 0.0018 0.0013 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0306 0.0862
Schistosoma mansoni zinc finger protein 0.0025 0.0097 0.0084
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0945 0.0933
Brugia malayi chromobox protein homolog 3 0.0039 0.0262 0.0708
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1132 0.3168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0125
Giardia lamblia Cathepsin L precursor 0.0019 0.0022 0.0075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0187 0.208 0.2069
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0138 0.0735
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0065 0.0578 0.5145
Brugia malayi nuclear hormone receptor 0.0054 0.0444 0.1221
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0362 0.3799
Trypanosoma brucei unspecified product 0.0036 0.0228 0.0628
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Echinococcus granulosus cathepsin L cysteine protease 0.0038 0.0247 0.0234
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.0426 0.0415
Brugia malayi tailless protein 0.0025 0.0097 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0125
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0019 0.0022 0.0164
Echinococcus multilocularis cysteine protease 0.0065 0.0578 0.0566
Loa Loa (eye worm) acetyltransferase 0.0144 0.1552 0.4378
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0272
Echinococcus granulosus metabotropic glutamate receptor 2 0.0085 0.0824 0.0812
Leishmania major cathepsin L-like protease 0.0065 0.0578 0.1655
Entamoeba histolytica cysteine protease, putative 0.0019 0.0022 0.0146
Brugia malayi Cathepsin L-like precursor 0.0046 0.0353 0.0963
Loa Loa (eye worm) hypothetical protein 0.0081 0.0785 0.2214
Giardia lamblia Cathepsin L-like protease 0.0019 0.0022 0.0075
Leishmania major cathepsin L-like protease 0.0065 0.0578 0.1655
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0733 0.2109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0012 0.0035
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0362 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1742 0.5064
Brugia malayi Papain family cysteine protease containing protein 0.0065 0.0578 0.1602
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0069 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0307 0.0861
Entamoeba histolytica cysteine protease, putative 0.0038 0.0247 0.4141
Echinococcus granulosus cathepsin l1 0.0065 0.0578 0.0566
Loa Loa (eye worm) hypothetical protein 0.0262 0.2999 0.846
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0785 0.0773
Plasmodium falciparum serine repeat antigen 7 0.0019 0.0022 0.0146

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.1331 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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