Detailed information for compound 1266134

Basic information

Technical information
  • TDR Targets ID: 1266134
  • Name: 1-[2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3- yl]-N,N-dimethylmethanamine
  • MW: 285.771 | Formula: C16H16ClN3
  • H donors: 0 H acceptors: 1 LogP: 3.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1c(nc2n1cccc2)c1ccc(cc1)Cl)C
  • InChi: 1S/C16H16ClN3/c1-19(2)11-14-16(12-6-8-13(17)9-7-12)18-15-5-3-4-10-20(14)15/h3-10H,11H2,1-2H3
  • InChiKey: MRNQMYQVAKMUSY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]-N,N-dimethyl-methanamine
  • 1-[2-(4-chlorophenyl)-3-imidazo[3,2-a]pyridinyl]-N,N-dimethylmethanamine
  • [2-(4-chlorophenyl)imidazo[3,2-a]pyridin-3-yl]methyl-dimethyl-amine
  • MLS000721745
  • SMR000335210
  • [2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dimethylmethanamine
  • 3N-532S
  • Oprea1_492882

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0106 0.0148
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Echinococcus multilocularis cysteine protease 0.002 0.0107 0.0084
Mycobacterium ulcerans hypothetical protein 0.011 0.1029 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0023 0.0013
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0148 0.0206
Onchocerca volvulus 0.002 0.0107 0.069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Echinococcus multilocularis cathepsin L 0.002 0.0107 0.0084
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0011 0.0009 0.0013
Loa Loa (eye worm) cathepsin B 0.0103 0.0961 0.1452
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0023 0.0021
Echinococcus multilocularis tar DNA binding protein 0.013 0.1237 0.1217
Echinococcus granulosus pyruvate kinase 0.0036 0.0267 0.0375
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.0222 0.0311
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0909 0.138
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1029 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.3035 0.4635
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0423 0.0401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0159
Schistosoma mansoni hypothetical protein 0.0195 0.1911 0.627
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0168 0.0235
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0175 0.0247
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0107 0.0279
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Loa Loa (eye worm) pyruvate kinase-PB 0.0049 0.04 0.0592
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0032 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0741 0.1116
Mycobacterium ulcerans polyketide synthase 0.0026 0.0168 0.1552
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0741 0.1122
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0618 0.5875
Echinococcus granulosus pyruvate kinase 0.007 0.0618 0.0914
Schistosoma mansoni hypothetical protein 0.0032 0.0226 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0032 0.0158
Schistosoma mansoni pyruvate kinase 0.007 0.0618 0.1975
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0046 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0107 0.1283
Schistosoma mansoni lamin 0.0027 0.0175 0.0505
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0226 0.0313
Echinococcus multilocularis GPCR, family 2 0.0032 0.0226 0.0204
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0107 0.1283
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0267 0.4013
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0609 0.0919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0023 0.0021
Giardia lamblia Cathepsin B precursor 0.0103 0.0961 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0107 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0273
Brugia malayi TAR-binding protein 0.013 0.1237 0.1882
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0107 0.025
Onchocerca volvulus 0.0029 0.0192 0.1294
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0267 0.2358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0159
Brugia malayi fibroinase precursor 0.0013 0.0032 0.0034
Brugia malayi nuclear receptor NHR-88 0.0012 0.0023 0.0021
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0109 0.098
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0152 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1316 0.1998
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi Cathepsin L-like precursor 0.0013 0.0032 0.0034
Schistosoma mansoni cathepsin S (C01 family) 0.0013 0.0032 0.003
Toxoplasma gondii cathepsin CPL 0.002 0.0107 0.0754
Brugia malayi cathepsin L-like precursor 0.0013 0.0032 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0023 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0226 0.0333
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0152 0.0218
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0118 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0023 0.0021
Leishmania major pyruvate kinase 0.007 0.0618 0.5539
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0345 0.0323
Echinococcus granulosus cathepsin b 0.0304 0.3035 0.4628
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0023 0.0095
Onchocerca volvulus 0.0027 0.0175 0.1171
Loa Loa (eye worm) pyruvate kinase 0.007 0.0618 0.0926
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0618 0.5539
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0023 0.0021
Onchocerca volvulus 0.002 0.0107 0.069
Loa Loa (eye worm) beta-lactamase 0.011 0.1029 0.1558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0023 0.0021
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0115 0.0162
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0175 0.0247
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Plasmodium vivax vivapain-1 0.002 0.0107 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0032 0.003
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.008 0.0112
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0011 0.0009 0.0013
Onchocerca volvulus Cathepsin L homolog 0.002 0.0107 0.069
Onchocerca volvulus 0.0027 0.0175 0.1171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0107 0.025
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0118 0.1465
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0192 0.147
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0278 0.2633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0152 0.1397
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0011 0.0009 0.0013
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0032 0.0034
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0107 0.0129
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0192 0.1793
Giardia lamblia Cathepsin B precursor 0.0103 0.0961 1
Brugia malayi pyruvate kinase 0.0015 0.0049 0.006
Brugia malayi hypothetical protein 0.0082 0.0741 0.1122
Mycobacterium ulcerans thioesterase 0.0021 0.0109 0.098
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0065 0.055
Loa Loa (eye worm) hypothetical protein 0.007 0.0618 0.0926
Schistosoma mansoni cathepsin C 0.0013 0.0032 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0032 0.0034
Brugia malayi cathepsin L-like cysteine proteinase 0.0013 0.0032 0.0034
Brugia malayi RNA recognition motif domain containing protein 0.013 0.1237 0.1882
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0222 0.0326
Trichomonas vaginalis esterase, putative 0.011 0.1029 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0152 0.1397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0909 0.1362
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) hypothetical protein 0.0643 0.6531 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0107 0.0279
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0102 0.0908
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0023 0.0021
Echinococcus granulosus lamin dm0 0.0027 0.0175 0.0234
Echinococcus multilocularis geminin 0.0195 0.1911 0.1893
Toxoplasma gondii ABC1 family protein 0.011 0.1029 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.1237 0.4031
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0118 0.0861
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0107 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0023 0.0021
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0618 0.0933
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0192 0.0926
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0741 0.1116
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.038 0.0568
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0222 0.0319
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0013 0.0032 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1316 0.1998
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0159
Loa Loa (eye worm) hypothetical protein 0.0043 0.0337 0.0496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Echinococcus granulosus pyruvate kinase 0.0036 0.0267 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0192 0.1793
Trypanosoma brucei cysteine peptidase C (CPC) 0.0103 0.0961 0.9255
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.0049 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0046 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0023 0.0021
Brugia malayi Peroxidasin 0.0082 0.0741 0.1122
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0618 0.5875
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0103 0.0961 0.3113
Entamoeba histolytica cysteine proteinase 1, putative 0.002 0.0107 0.0688
Brugia malayi hypothetical protein 0.0043 0.0345 0.0515
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0423 0.0615
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0273
Echinococcus multilocularis cathepsin L 0.0013 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0142
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0192 0.1793
Toxoplasma gondii cathepsin B 0.0103 0.0961 0.9311
Schistosoma mansoni hypothetical protein 0.0032 0.0226 0.0676
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0618 0.1952
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0192 0.028
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2843 0.4333
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0023 0.0021
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0741 0.1122
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0152 0.1397
Brugia malayi nuclear hormone receptor 0.0012 0.0023 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0023 0.0013
Onchocerca volvulus 0.0082 0.0741 0.5177
Brugia malayi hypothetical protein 0.0148 0.1423 0.2168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1029 0.1558
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0107 0.0084
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0168 0.0235
Echinococcus multilocularis muscleblind protein 1 0.0643 0.6531 0.6523
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0192 0.027
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Mycobacterium ulcerans beta-lactamase 0.011 0.1029 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0107 0.1283
Schistosoma mansoni hypothetical protein 0.0032 0.0226 0.0676
Entamoeba histolytica hypothetical protein 0.0043 0.0345 0.2871
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0107 0.015
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1143 0.3717
Giardia lamblia Pyruvate kinase 0.0036 0.0267 0.2532
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0107 0.025
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0152 0.1397
Schistosoma mansoni intermediate filament proteins 0.0027 0.0175 0.0505
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0741 0.5177
Echinococcus granulosus cathepsin b 0.0304 0.3035 0.4628
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Plasmodium vivax vivapain-3 0.002 0.0107 0.0754
Leishmania major pyruvate kinase 0.007 0.0618 0.5539
Loa Loa (eye worm) pyruvate kinase 0.007 0.0618 0.0926
Mycobacterium ulcerans polyketide synthase 0.0025 0.0152 0.1397
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0618 0.1952
Schistosoma mansoni hypothetical protein 0.0049 0.0404 0.1267
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0345 0.107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0159
Echinococcus granulosus peroxidasin 0.0082 0.0741 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0107 0.025
Mycobacterium ulcerans lipase LipD 0.011 0.1029 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0939 0.1418
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0192 0.1793
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0152 0.0213
Echinococcus granulosus muscleblind protein 0.0643 0.6531 1
Entamoeba histolytica hypothetical protein 0.0043 0.0345 0.2871
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Entamoeba histolytica cysteine proteinase 2 0.002 0.0107 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0103 0.0961 0.9311
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0026
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0304 0.3035 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1423 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0078 0.0467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0909 0.0888
Onchocerca volvulus 0.0082 0.0741 0.5177
Onchocerca volvulus 0.0051 0.0427 0.2956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0107 0.0142
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0226 0.0326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0226 0.0313
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0404 0.1267
Loa Loa (eye worm) hypothetical protein 0.0049 0.04 0.0592
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0741 0.1116
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1029 1
Loa Loa (eye worm) RNA binding protein 0.013 0.1237 0.1876
Onchocerca volvulus 0.011 0.1029 0.7214
Mycobacterium tuberculosis Conserved protein 0.011 0.1029 0.1443
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1029 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0618 0.0933
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0226 0.0204
Schistosoma mansoni tar DNA-binding protein 0.013 0.1237 0.4031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0192 0.1793
Schistosoma mansoni cathepsin B (C01 family) 0.0013 0.0032 0.003
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1029 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0109 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0192 0.1793
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Onchocerca volvulus 0.0012 0.0023 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0423 0.0628
Loa Loa (eye worm) hypothetical protein 0.0032 0.0226 0.0326
Onchocerca volvulus 0.002 0.0107 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0023 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0106 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0909 0.1362
Loa Loa (eye worm) cysteine protease 0.002 0.0107 0.0142
Schistosoma mansoni hypothetical protein 0.0049 0.0404 0.1267
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0144 0.0202
Loa Loa (eye worm) pyruvate kinase 0.0015 0.0049 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.165 0.25
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0909 0.1373
Brugia malayi Cathepsin L-like precursor 0.0013 0.0032 0.0034
Brugia malayi hypothetical protein 0.0286 0.2843 0.4345
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0023 0.0013
Schistosoma mansoni peroxidasin 0.0082 0.0741 0.2386
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0226 0.0333
Onchocerca volvulus Chorion peroxidase homolog 0.0082 0.0741 0.5177
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0144 0.0202
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0741 0.5177
Echinococcus granulosus pyruvate kinase 0.0036 0.0267 0.0375
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0038 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0107 0.025
Giardia lamblia Pyruvate kinase 0.007 0.0618 0.631
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0107 0.0279
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0278 0.2633
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0023 0.0021
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0152 0.1397
Loa Loa (eye worm) hypothetical protein 0.0643 0.6531 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0192 0.028
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0032 0.0034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0701 0.7132 1
Entamoeba histolytica pyruvate kinase, putative 0.0049 0.04 0.337
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0741 0.1122
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0107 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0107 0.0754
Schistosoma mansoni survival motor neuron protein 0.0058 0.0498 0.1577
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0023 0.0095
Plasmodium vivax hypothetical protein, conserved 0.011 0.1029 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1124 0.1708
Brugia malayi ecdysteroid receptor 0.0012 0.0023 0.0021
Echinococcus granulosus geminin 0.0195 0.1911 0.2902
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0107 0.025
Onchocerca volvulus Cathepsin F homolog 0.002 0.0107 0.069
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Onchocerca volvulus 0.002 0.0107 0.069
Schistosoma mansoni hypothetical protein 0.0032 0.0226 0.0676
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.0107 0.025
Echinococcus granulosus intermediate filament protein 0.0027 0.0175 0.0234
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0107 0.015
Onchocerca volvulus 0.002 0.0107 0.069
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0618 0.5965
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0023 0.0021
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0042 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Mycobacterium tuberculosis Conserved protein 0.011 0.1029 0.1443
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0103 0.0961 0.9255
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0109 0.098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.3035 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0939 0.1425
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0192 0.0926
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0065 0.055
Mycobacterium ulcerans pyruvate kinase 0.007 0.0618 0.5965
Chlamydia trachomatis pyruvate kinase 0.007 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0031 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0741 0.1122
Echinococcus granulosus tar DNA binding protein 0.013 0.1237 0.1865
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0168 0.1552
Loa Loa (eye worm) ctsf protein 0.002 0.0107 0.0142
Echinococcus granulosus lamin 0.0027 0.0175 0.0234
Giardia lamblia Cathepsin B precursor 0.0103 0.0961 1
Onchocerca volvulus 0.011 0.1029 0.7214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Trypanosoma brucei pyruvate kinase 1 0.007 0.0618 0.5539
Plasmodium vivax pyruvate kinase, putative 0.007 0.0618 0.5875
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0192 0.028
Plasmodium vivax vivapain-2 0.002 0.0107 0.0754
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.018 0.1483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0023 0.0013
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0152 0.1397
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0106 0.0148
Brugia malayi Muscleblind-like protein 0.0643 0.6531 1
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1029 0.1443
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Brugia malayi cathepsin Z-like cysteine proteinase 0.0013 0.0032 0.0034
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0267 0.2358
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0168 0.1552
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0013 0.0032 0.003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0107 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1029 0.1443
Loa Loa (eye worm) hypothetical protein 0.0148 0.1423 0.2162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Brugia malayi beta-lactamase family protein 0.011 0.1029 0.1564
Echinococcus granulosus cathepsin l1 0.002 0.0107 0.0129
Loa Loa (eye worm) fibroinase 0.002 0.0107 0.0142
Echinococcus granulosus expressed conserved protein 0.0112 0.1049 0.1577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0192 0.027
Echinococcus granulosus pyruvate kinase 0.007 0.0618 0.0914
Loa Loa (eye worm) hypothetical protein 0.0119 0.1124 0.1702
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0939 0.1425
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0423 0.0628
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0065 0.055
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0107 0.1283
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0032 0.0027
Echinococcus multilocularis pyruvate kinase 0.0036 0.0267 0.0245
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0159
Onchocerca volvulus Cathepsin L homolog 0.002 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Onchocerca volvulus Peroxidase homolog 0.0082 0.0741 0.5177
Schistosoma mansoni hypothetical protein 0.0069 0.0609 0.1946
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0107 0.025
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.165 0.1631
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0909 0.0888
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0062 0.0542 0.081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0345 0.0495
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0102 0.0908
Echinococcus multilocularis cysteine protease 0.002 0.0107 0.0084
Onchocerca volvulus Huntingtin homolog 0.0148 0.1423 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1029 0.3322
Schistosoma mansoni pyruvate kinase 0.0036 0.0267 0.081
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0107 0.0279
Brugia malayi intermediate filament protein 0.0027 0.0175 0.0254
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Onchocerca volvulus 0.0031 0.0222 0.1502
Schistosoma mansoni tar DNA-binding protein 0.013 0.1237 0.4031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Onchocerca volvulus Dual oxidase homolog 0.0082 0.0741 0.5177
Onchocerca volvulus 0.0082 0.0741 0.5177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0618 0.4303
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1029 0.1564
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0032 0.0027
Schistosoma mansoni lamin 0.0027 0.0175 0.0505
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0168 0.1552
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1029 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0018
Echinococcus multilocularis muscleblind protein 0.0643 0.6531 0.6523
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0168 0.1552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0226 0.0204
Schistosoma mansoni peroxidasin 0.0082 0.0741 0.2386
Echinococcus granulosus cysteine protease 0.002 0.0107 0.0129
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0168 0.1552
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2843 0.2827
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0618 0.5875
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0939 0.1418
Schistosoma mansoni tar DNA-binding protein 0.013 0.1237 0.4031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.0218 0.1706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0909 0.2942
Echinococcus multilocularis protein patched 0.0051 0.0423 0.0401
Echinococcus multilocularis cathepsin b 0.0304 0.3035 0.3019
Schistosoma mansoni hypothetical protein 0.0058 0.0498 0.1577
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Schistosoma mansoni hypothetical protein 0.0195 0.1911 0.627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Echinococcus multilocularis cathepsin b 0.0304 0.3035 0.3019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0107 0.0754
Echinococcus granulosus cathepsin L 0.0013 0.0032 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0192 0.1793
Brugia malayi MH2 domain containing protein 0.0138 0.1316 0.2004
Mycobacterium leprae Probable lipase LipE 0.011 0.1029 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0498 0.0476
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0032 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1029 1
Schistosoma mansoni pyruvate kinase 0.007 0.0618 0.1975
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Echinococcus granulosus GPCR family 2 0.0032 0.0226 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Brugia malayi RNA binding protein 0.013 0.1237 0.1882
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Onchocerca volvulus Peroxidase homolog 0.0082 0.0741 0.5177
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0032 0.0034
Brugia malayi CHE-14 protein 0.0051 0.0423 0.0635
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0106 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1029 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0909 0.2942
Brugia malayi cathepsin B-like cysteine proteinase 0.0304 0.3035 0.4639
Onchocerca volvulus 0.0013 0.0032 0.0158
Entamoeba histolytica hypothetical protein 0.0043 0.0345 0.2871
Echinococcus multilocularis lamin 0.0027 0.0175 0.0152
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0168 0.0235
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Schistosoma mansoni hypothetical protein 0.0049 0.0404 0.1267
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1029 0.1443
Loa Loa (eye worm) blistered cuticle protein 3 0.0082 0.0741 0.1116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0032 0.003
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.1237 0.1876
Echinococcus granulosus cathepsin l1 0.0013 0.0032 0.0014
Schistosoma mansoni patched 1 0.0051 0.0423 0.133
Leishmania major hypothetical protein, conserved 0.011 0.1029 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1029 0.1009
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0304 0.3035 1
Brugia malayi beta-lactamase 0.011 0.1029 0.1564
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0118 0.1061
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0423 0.0615
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1029 0.1443
Plasmodium vivax unspecified product 0.002 0.0107 0.0754
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0107 0.0129
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0026 0.017 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0023 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1124 0.1103
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0356 0.2455
Plasmodium falciparum pyruvate kinase 0.007 0.0618 1
Plasmodium vivax vivapain-2 0.002 0.0107 0.0754
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.3035 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0498 0.0749
Echinococcus multilocularis musashi 0.0027 0.0175 0.0152
Echinococcus multilocularis peroxidasin 0.0082 0.0741 0.072
Brugia malayi Blistered cuticle protein 3 0.0082 0.0741 0.1122
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0032 0.003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0023 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1029 0.1443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1029 0.3342
Mycobacterium ulcerans hypothetical protein 0.0029 0.0192 0.1793
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1029 0.3342
Echinococcus multilocularis lamin dm0 0.0027 0.0175 0.0152
Brugia malayi cathepsin L precursor 0.0013 0.0032 0.0034
Onchocerca volvulus 0.002 0.0107 0.069
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0278 0.039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.3035 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0013 0.0032 0.0034
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0013 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1558
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0013
Onchocerca volvulus 0.0013 0.0032 0.0158
Loa Loa (eye worm) hypothetical protein 0.0286 0.2843 0.4341
Echinococcus multilocularis pyruvate kinase 0.0036 0.0267 0.0245
Entamoeba histolytica hypothetical protein 0.0043 0.0345 0.2871
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0032 0.003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0031 0.0013
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0618 0.4303
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Mycobacterium tuberculosis Conserved protein 0.011 0.1029 0.1443
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Brugia malayi beta-lactamase family protein 0.011 0.1029 0.1564
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0032 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1124 0.1691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0023 0.0013
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0013 0.0032 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0192 0.147
Echinococcus multilocularis pyruvate kinase 0.007 0.0618 0.0596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0013 0.0032 0.003
Loa Loa (eye worm) TAR-binding protein 0.013 0.1237 0.1876
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0103 0.0961 0.3093
Loa Loa (eye worm) pyruvate kinase 0.007 0.0618 0.0926
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0107 0.025
Entamoeba histolytica cysteine protease, putative 0.002 0.0107 0.0688
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0152 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0039
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0105 0.0148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1029 0.1443
Echinococcus multilocularis pyruvate kinase 0.0055 0.0466 0.0444
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0192 0.1793
Loa Loa (eye worm) hypothetical protein 0.0069 0.0609 0.0913
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1029 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1124 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0023 0.0095
Schistosoma mansoni tar DNA-binding protein 0.013 0.1237 0.4031
Echinococcus multilocularis pyruvate kinase 0.0036 0.0267 0.0245
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0618 0.4303
Loa Loa (eye worm) hypothetical protein 0.0148 0.1423 0.2162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0107 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0423 0.3925
Onchocerca volvulus 0.002 0.0107 0.069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0909 0.2942
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0273
Brugia malayi steroid hormone receptor 0.0012 0.0023 0.0021
Schistosoma mansoni hypothetical protein 0.0043 0.0345 0.107
Onchocerca volvulus 0.011 0.1029 0.7214
Mycobacterium leprae conserved hypothetical protein 0.011 0.1029 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0278 0.039
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0107 0.015
Trypanosoma cruzi cysteine protease, putative 0.002 0.0107 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Echinococcus multilocularis expressed conserved protein 0.0112 0.1049 0.1029
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0013 0.0032 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1029 0.1443
Onchocerca volvulus 0.0058 0.0498 0.3455
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0175 0.0254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0107 0.0754
Echinococcus multilocularis pyruvate kinase 0.007 0.0618 0.0596
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0027
Echinococcus granulosus cathepsin L 0.002 0.0107 0.0129
Brugia malayi Cathepsin L-like precursor 0.002 0.0107 0.015
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0062 0.0306
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0741 0.1122
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0192 0.1793
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0192 0.0926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0107 0.0754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0741 0.1116
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0741 0.1116
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0618 0.0866
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0102 0.0908
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0107 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1029 0.3322
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0011 0.0009 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1029 0.1546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0316 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.99 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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