Detailed information for compound 1277967

Basic information

Technical information
  • TDR Targets ID: 1277967
  • Name: (2-dimethylamino-2-oxoethyl) (2S)-2-(furan-2- carbonylamino)-3-phenylpropanoate
  • MW: 344.362 | Formula: C18H20N2O5
  • H donors: 1 H acceptors: 3 LogP: 2.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](NC(=O)c1ccco1)Cc1ccccc1)OCC(=O)N(C)C
  • InChi: 1S/C18H20N2O5/c1-20(2)16(21)12-25-18(23)14(11-13-7-4-3-5-8-13)19-17(22)15-9-6-10-24-15/h3-10,14H,11-12H2,1-2H3,(H,19,22)/t14-/m0/s1
  • InChiKey: HWQNXDMHBPXKLI-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-dimethylamino-2-oxo-ethyl) (2S)-2-(furan-2-carbonylamino)-3-phenyl-propanoate
  • (2S)-2-[(2-furyl-oxomethyl)amino]-3-phenylpropanoic acid (2-dimethylamino-2-oxoethyl) ester
  • (2S)-2-(furan-2-carbonylamino)-3-phenyl-propionic acid (2-dimethylamino-2-keto-ethyl) ester
  • (2-dimethylamino-2-oxo-ethyl) (2S)-2-(furan-2-ylcarbonylamino)-3-phenyl-propanoate
  • SMR000150833
  • ZINC03284079
  • T0520-0873
  • MLS000571151

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi histone deacetylase 3 (HD3) 0.1285 0.298 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.006 0.0123 0.0405
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0009 0.0004 0.0004
Leishmania major modification methylase-like protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0112 0.0243 0.0806
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0086 0.0282
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0101 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0044 0.0138
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0086 0.029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0072 0.0161
Echinococcus multilocularis carbonic anhydrase 0.0224 0.0506 0.0506
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0072 1
Echinococcus granulosus expressed conserved protein 0.0105 0.0227 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.1285 0.298 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0086 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0247 0.0828
Leishmania major DNA polymerase eta, putative 0.002 0.003 0.0092
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0086 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.006 0.0123 0.0405
Entamoeba histolytica hypothetical protein 0.0084 0.0179 0.0592
Plasmodium falciparum histone deacetylase 1 0.1285 0.298 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0003 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0044 0.0138
Echinococcus granulosus histone deacetylase 6 0.1129 0.2615 0.8776
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0018 0.0035
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0159 0.0159
Trypanosoma cruzi histone deacetylase, putative 0.0536 0.1232 0.413
Echinococcus granulosus disco interacting protein 2 0.002 0.0029 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0044 0.0147
Schistosoma mansoni patched 1 0.0048 0.0094 0.0316
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0051
Onchocerca volvulus 0.0046 0.0089 0.0705
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.0395 0.0395
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.006 0.0123 0.0414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0068 0.015
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1865 0.4334 1
Echinococcus multilocularis disco interacting protein 2 0.002 0.0029 0.0029
Echinococcus multilocularis GPCR, family 2 0.0072 0.0151 0.0151
Brugia malayi TAR-binding protein 0.0076 0.0159 0.0525
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0086 0.0282
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0224 0.0506 0.1691
Schistosoma mansoni coup transcription factor 0.0026 0.0044 0.0147
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0024 0.0038 0.0119
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0228 0.0515 0.1722
Trypanosoma cruzi histone deacetylase, putative 0.1129 0.2615 0.8775
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.006 0.0123 0.0405
Brugia malayi hypothetical protein 0.0014 0.0015 0.0041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0101 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0044 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0044 0.0138
Schistosoma mansoni hypothetical protein 0.0072 0.0151 0.0507
Echinococcus granulosus GPCR family 2 0.0072 0.0151 0.0507
Echinococcus multilocularis deoxyribonuclease 1 2 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0277 0.0628 0.2101
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0031 0.0095
Echinococcus granulosus tumor protein p63 0.0329 0.075 0.2515
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0395 0.1324
Schistosoma mansoni hypothetical protein 0.0156 0.0347 0.1163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0103 0.0195
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0092
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.0354 0.0354
Schistosoma mansoni carbonic anhydrase-related 0.0224 0.0506 0.1698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0332 0.1114
Trypanosoma brucei histone deacetylase 4 0.1129 0.2615 0.8775
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.006 0.0123 0.0405
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0031 0.0095
Schistosoma mansoni histone deacetylase 0.1285 0.298 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.0243 0.0806
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0031 0.0031
Onchocerca volvulus Histone deacetylase 10 homolog 0.0536 0.1232 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0101 0.0331
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0072 0.0151 0.0151
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0021 0.0032 0.0032
Leishmania major udp-glc 4-epimerase, putative 0.0023 0.0036 0.0113
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0018 0.0051
Entamoeba histolytica hypothetical protein 0.0084 0.0179 0.0592
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0044 0.0147
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0011 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0376 0.0861 0.2882
Entamoeba histolytica hypothetical protein 0.0084 0.0179 0.0592
Schistosoma mansoni histone deacetylase 0.1285 0.298 1
Brugia malayi histone deacetylase 1 (HD1) 0.1285 0.298 1
Toxoplasma gondii histone deacetylase HDAC5 0.0536 0.1232 0.413
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1886 0.4383 1
Schistosoma mansoni hypothetical protein 0.0177 0.0396 0.1328
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0044 0.0138
Schistosoma mansoni inositol monophosphatase 0.0045 0.0086 0.029
Echinococcus multilocularis protein dispatched 1 0.0055 0.011 0.011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0086 0.0282
Plasmodium vivax hypothetical protein, conserved 0.006 0.0123 0.0405
Trypanosoma brucei carbonic anhydrase-like protein 0.0376 0.0861 0.2882
Echinococcus granulosus flap endonuclease 1 0.0025 0.0042 0.0139
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0094 0.0316
Echinococcus multilocularis expressed conserved protein 0.0105 0.0227 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0011 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0082 0.0268
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0018 0.0035
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.006 0.0123 0.0123
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0042 0.0131
Schistosoma mansoni hypothetical protein 0.0046 0.009 0.0302
Onchocerca volvulus 0.0012 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0277 0.0628 0.2101
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0042 0.0131
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0243 0.0243
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0021 0.0032 0.0107
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0018 0.0035
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0009 0.0004 0.0004
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0009 0.0004 0.0004
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.006 0.0123 0.0414
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0103 0.0337
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0092
Mycobacterium ulcerans DNA polymerase IV 0.002 0.003 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0092
Trypanosoma brucei UDP-galactose 4-epimerase 0.0023 0.0036 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0044 0.0138
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.0243 0.0806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0179 0.06
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0021 0.0032 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0042
Entamoeba histolytica hypothetical protein 0.0084 0.0179 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0332 0.0332
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0086 0.0282
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0086 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Trypanosoma brucei histone deacetylase 3 0.1129 0.2615 0.8775
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0094 0.0307
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0101 0.0331
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Leishmania major histone deacetylase, putative 0.1129 0.2615 0.8775
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0235
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0257 0.0583 0.1957
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0042 0.0131
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0004 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0092
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0011 0.0029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.003 0.0063
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.003 0.0092
Brugia malayi nuclear receptor RXR 0.0014 0.0015 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Loa Loa (eye worm) DR-78 0.0012 0.0011 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0159 0.0525
Leishmania major histone deacetylase, putative 0.1129 0.2615 0.8775
Brugia malayi DKFZp564C0469 protein 0.0021 0.0031 0.0095
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0224 0.0506 0.1691
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0021 0.0032 0.0098
Entamoeba histolytica hypothetical protein 0.0021 0.0031 0.0095
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0044 0.0334
Schistosoma mansoni topbp1 0.0021 0.0031 0.0103
Trypanosoma brucei unspecified product 0.002 0.003 0.0092
Echinococcus multilocularis synaptojanin 1 0.0009 0.0003 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0082 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0082 0.0184
Echinococcus multilocularis histone deacetylase 6 0.1129 0.2615 0.2615
Echinococcus granulosus carbonic anhydrase 0.0224 0.0506 0.1698
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0011 0.0029
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0011 0.0008 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0011 0.0011
Brugia malayi hypothetical protein 0.0012 0.0011 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.006 0.0123 0.0405
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0031 0.0095
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0042 0.0131
Schistosoma mansoni hypothetical protein 0.0084 0.0179 0.06
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0092
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0018 0.0051
Loa Loa (eye worm) histone deacetylase 3 0.1285 0.298 1
Leishmania major carbonic anhydrase-like protein 0.0376 0.0861 0.2882
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0015 0.0015
Brugia malayi RNA binding protein 0.0076 0.0159 0.0525
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0011 0.0071
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0009
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0021 0.0032 0.0098
Schistosoma mansoni zinc finger protein 0.0012 0.0011 0.0038
Treponema pallidum DNA ligase (lig) 0.0021 0.0031 0.3531
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0018 0.0018
Echinococcus granulosus synaptojanin 1 0.0009 0.0003 0.0009
Echinococcus granulosus histone deacetylase 6 0.1129 0.2615 0.8776
Brugia malayi Histone deacetylase 1 0.1285 0.298 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0159 0.0525
Schistosoma mansoni brca1-associated protein (brap2) 0.006 0.0123 0.0414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0086 0.0282
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1886 0.4383 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0031 0.0095
Brugia malayi Inositol-1 0.0045 0.0086 0.0282
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.015 0.0333 0.1119
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0031 0.0095
Loa Loa (eye worm) histone deacetylase 1 0.1285 0.298 1
Onchocerca volvulus 0.0015 0.0018 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.006 0.0123 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0044 0.0138
Giardia lamblia Hypothetical protein 0.006 0.0123 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0159 0.0534
Brugia malayi latrophilin 2 splice variant baaae 0.0156 0.0347 0.1155
Plasmodium falciparum histone deacetylase 2 0.1129 0.2615 0.8775
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0159 0.0534
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0018 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0068 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0031 0.0095
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0031 0.0103
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0021 0.0032 0.0107
Brugia malayi ecdysone receptor 0.0012 0.0011 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.0332 0.1106
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0091 0.0298
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0018 0.0051
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0376 0.0861 0.2882
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0224 0.0506 0.1691
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0103 0.0337
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.006 0.0123 0.0405
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0103 0.0195
Schistosoma mansoni carbon catabolite repressor protein 0.0009 0.0003 0.0009
Schistosoma mansoni brca1-associated protein (brap2) 0.006 0.0123 0.0414
Schistosoma mansoni synaptojanin 0.0009 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0046 0.009 0.0302
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0376 0.0861 0.2888
Onchocerca volvulus 0.0012 0.0011 0.0071
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.006 0.0123 0.0405
Echinococcus granulosus histone deacetylase 0.1129 0.2615 0.8776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0044 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0044 0.0147
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0224 0.0506 0.1691
Schistosoma mansoni flap endonuclease-1 0.0023 0.0036 0.012
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.006 0.0123 0.0405
Schistosoma mansoni histone deacetylase hda2 0.1189 0.2756 0.9249
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0021 0.0032 0.0098
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0011 0.0011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0179 0.06
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Schistosoma mansoni UDP-glucose 4-epimerase 0.0024 0.0038 0.0128
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0044 0.0147
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.006 0.0123 0.0405
Plasmodium vivax histone deacetylase 1, putative 0.1285 0.298 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0044 0.0138
Echinococcus multilocularis dna polymerase kappa 0.002 0.003 0.003
Toxoplasma gondii histone deacetylase HDAC4 0.0536 0.1232 0.413
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0024 0.0038 0.0119
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0044 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0179 0.0179
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0159 0.0525
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0044 0.0147
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0044 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0072 0.0151 0.0498
Loa Loa (eye worm) hypothetical protein 0.0536 0.1232 0.413
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0015 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0332 0.1114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Echinococcus multilocularis histone deacetylase 1 0.1285 0.298 0.298
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.006 0.0123 0.0405
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0011 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0072 0.0151 0.0507
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0021 0.0032 0.0068
Mycobacterium ulcerans DNA polymerase IV 0.002 0.003 0.0028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0032 0.0068
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.006 0.0123 0.0405
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0011 0.0011
Echinococcus multilocularis histone deacetylase 6 0.1189 0.2756 0.2756
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0235
Echinococcus granulosus traf and tnf receptor associated protein 0.0009 0.0003 0.0009
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.006 0.0123 0.0405
Schistosoma mansoni survival motor neuron protein 0.0056 0.0114 0.0383
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0082 0.0082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0086 0.0282
Onchocerca volvulus 0.0015 0.0018 0.0124
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.0354 0.1189
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0103 0.0337
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.006 0.0123 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0044 0.0138
Loa Loa (eye worm) inositol-1 0.0045 0.0086 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0095
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0011 0.0029
Onchocerca volvulus 0.0021 0.0031 0.0229
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0042 0.0131
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0031 0.0095
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0103 0.0195
Leishmania major hypothetical protein, conserved 0.006 0.0123 0.0405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0044 0.0147
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0082 0.0268
Loa Loa (eye worm) hypothetical protein 0.0702 0.1621 0.5434
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0103 0.0195
Leishmania major DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0044 0.0138
Schistosoma mansoni hypothetical protein 0.0072 0.0151 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0044 0.0138
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0042 0.0131
Schistosoma mansoni carbonic anhydrase 0.0224 0.0506 0.1698
Echinococcus multilocularis neutral sphingomyelinase 0.0009 0.0003 0.0003
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Toxoplasma gondii hypothetical protein 0.0224 0.0506 0.1691
Echinococcus multilocularis nibrin 0.0021 0.0031 0.0031
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0086 0.0282
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0082 0.0268
Echinococcus granulosus histone deacetylase 7 0.1129 0.2615 0.8776
Echinococcus granulosus histone deacetylase 6 0.1189 0.2756 0.9249
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0014
Schistosoma mansoni DNA polymerase eta 0.002 0.003 0.01
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0042
Plasmodium vivax histone deacetylase 2, putative 0.1129 0.2615 0.8775
Echinococcus granulosus cpg binding protein 0.0048 0.0093 0.0313
Schistosoma mansoni histone deacetylase hda2 0.0536 0.1232 0.4135
Toxoplasma gondii histone deacetylase HDAC3 0.1285 0.298 1
Schistosoma mansoni cpg binding protein 0.0046 0.0089 0.03
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0103 0.0337
Echinococcus granulosus geminin 0.0177 0.0396 0.1328
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0011 0.0038
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0031 0.0095
Brugia malayi topoisomerase 0.0021 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0151 0.0498
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.006 0.0123 0.0414
Schistosoma mansoni topbp1 0.0021 0.0031 0.0103
Brugia malayi hypothetical protein 0.0012 0.0011 0.0029
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0011 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0044 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0044 0.0147
Loa Loa (eye worm) hypothetical protein 0.0593 0.1365 0.4577
Plasmodium vivax histone deacetylase, putative 0.1129 0.2615 0.8775
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.006 0.0123 0.0405
Brugia malayi histone deacetylase 11 0.0536 0.1232 0.413
Onchocerca volvulus 0.0015 0.0018 0.0124
Loa Loa (eye worm) histone deacetylase 7A 0.1129 0.2615 0.8775
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0044 0.0138
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0009 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0044 0.0138
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0173 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0044 0.0147
Schistosoma mansoni inositol monophosphatase 0.0045 0.0086 0.029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0235
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0051
Echinococcus granulosus DNA methyltransferase 2, putative 0.0009 0.0004 0.0013
Echinococcus granulosus BRCA1 associated protein 0.006 0.0123 0.0414
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0082 0.0268
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0024 0.0038 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0332 0.0332
Schistosoma mansoni neutral sphingomyelinase 0.0009 0.0003 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.0332 0.1106
Brugia malayi nuclear receptor RXR 0.0012 0.0011 0.0029
Echinococcus granulosus UDP glucose 4 epimerase 0.0024 0.0038 0.0128
Schistosoma mansoni nuclear receptor 0.0012 0.0011 0.0038
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0009 0.0004 0.0013
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0042 0.0131
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0021 0.0032 0.0098
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0018 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0044 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Onchocerca volvulus 0.0018 0.0024 0.0174
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0018 0.0035
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0076 0.0168
Echinococcus granulosus dna polymerase eta 0.002 0.003 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Brugia malayi Disco-interacting protein 2 homolog 0.0018 0.0024 0.0072
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.003 0.0092
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1285 0.298 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0132 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Loa Loa (eye worm) carbonic anhydrase 3 0.0376 0.0861 0.2882
Echinococcus multilocularis histone deacetylase 7 0.1129 0.2615 0.2615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0042
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0021 0.0032 0.0098
Leishmania major histone deacetylase, putative 0.1285 0.298 1
Schistosoma mansoni hypothetical protein 0.015 0.0333 0.1119
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0018 0.0051
Echinococcus granulosus neutral sphingomyelinase 0.0009 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0044 0.0334
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0015 0.0041
Trypanosoma cruzi histone deacetylase, putative 0.0536 0.1232 0.413
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0082 0.0268
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0076 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0031 0.0095
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0021 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0015 0.0042
Echinococcus granulosus tar DNA binding protein 0.0076 0.0159 0.0534
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0235
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0015 0.005
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0011 0.0038
Echinococcus granulosus histone deacetylase 8 0.0536 0.1232 0.4135
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.006 0.0123 0.0405
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0031 0.0095
Echinococcus multilocularis dna polymerase eta 0.002 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Giardia lamblia UDP-glucose 4-epimerase 0.0023 0.0036 0.0113
Loa Loa (eye worm) CXXC zinc finger family protein 0.0046 0.0089 0.0291
Schistosoma mansoni histone deacetylase 4 5 0.1129 0.2615 0.8776
Schistosoma mansoni carbonic anhydrase-related 0.0224 0.0506 0.1698
Schistosoma mansoni cpg binding protein 0.0048 0.0093 0.0313
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0044 0.0147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0095
Brugia malayi hypothetical protein 0.0084 0.0179 0.0592
Echinococcus multilocularis BRCA1 associated protein 0.006 0.0123 0.0123
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0009 0.0003 0.0003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0101 0.0331
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0021 0.0032 0.0098
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.0052 0.0103 0.0337
Schistosoma mansoni nocturnin 0.0009 0.0003 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0095
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0082 0.0268
Brugia malayi Flap endonuclease-1 0.0025 0.0042 0.0131
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0018 0.0051
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0072 0.0151 0.0498
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0009 0.0004 0.0004
Echinococcus granulosus carbonic anhydrase 0.0224 0.0506 0.1698
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0082 0.0268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.006 0.0123 0.0414
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.006 0.0123 0.0982
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.006 0.0123 0.0405
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0021 0.0032 0.0098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0044 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0159 0.0534
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0159 0.0534
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0332 0.1114
Echinococcus multilocularis carbonic anhydrase 0.0224 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0056 0.0114 0.0383
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.0031 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0243 0.0814
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0376 0.0861 0.2888
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0414 0.0947 0.3173
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.003 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.003 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0044 0.0147
Trypanosoma brucei unspecified product 0.0014 0.0015 0.0042
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0031 0.0095
Leishmania major pantothenate kinase subunit, putative 0.0011 0.0008 0.0017
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1285 0.298 1
Brugia malayi acetyltransferase, GNAT family protein 0.0173 0.0386 0.1289
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.006 0.0123 0.0405
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0018 0.006
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0021 0.0032 0.0098
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0103 0.0195
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0018 0.0051
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0031 0.0095
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0011 0.0038
Echinococcus granulosus dna polymerase kappa 0.002 0.003 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.0095 0.0309
Trypanosoma cruzi histone deacetylase, putative 0.1129 0.2615 0.8775
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Schistosoma mansoni synaptojanin 0.0009 0.0003 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0082 0.0268
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0094 0.0094
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0013 0.0024
Entamoeba histolytica histone deacetylase, putative 0.1285 0.298 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0011 0.0071
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0094 0.0316
Brugia malayi Histone deacetylase family protein 0.1129 0.2615 0.8775
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Brugia malayi nuclear receptor NHR-67 0.0012 0.0011 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0044 0.0138
Schistosoma mansoni ap endonuclease 0.0043 0.0082 0.0277
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0376 0.0861 0.2882
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0095 0.0318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0044 0.0138
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0031 0.0095
Echinococcus multilocularis UDP glucose 4 epimerase 0.0024 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0119 0.0392
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.003 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0103 0.0337
Onchocerca volvulus 0.0052 0.0103 0.0816
Trypanosoma cruzi histone deacetylase 1, putative 0.1285 0.298 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0103 0.0195
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0103 0.0337
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.006 0.0123 0.0405
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0159 0.0525
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.006 0.0123 0.0405
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0018 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0103 0.0232
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0042 0.0131
Echinococcus granulosus carbonic anhydrase II 0.0376 0.0861 0.2888
Brugia malayi Calcitonin receptor-like protein seb-1 0.0228 0.0515 0.1722
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0044 0.0147
Schistosoma mansoni cpg binding protein 0.0048 0.0093 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.015 0.0333 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0044 0.0138
Toxoplasma gondii exonuclease III APE 0.0043 0.0082 0.0268
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0395 0.1324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0103 0.0337
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0072 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0082 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Leishmania major hypothetical protein, conserved 0.006 0.0123 0.0405
Toxoplasma gondii hypothetical protein 0.0039 0.0074 0.0239
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0031 0.0103
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0011 0.0029
Brugia malayi nuclear hormone receptor 0.0012 0.0011 0.0029
Plasmodium falciparum histone deacetylase, putative 0.1129 0.2615 0.8775
Loa Loa (eye worm) hypothetical protein 0.0052 0.0103 0.0337
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0257 0.0583 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus granulosus nibrin 0.0021 0.0031 0.0103
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0011 0.0029
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.006 0.0123 0.0405
Echinococcus granulosus carbonic anhydrase 0.0224 0.0506 0.1698
Plasmodium vivax histone deacetylase, putative 0.0536 0.1232 0.413
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0021 0.0032 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0015 0.005
Schistosoma mansoni hypothetical protein 0.0046 0.009 0.0302
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0114 0.0374
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0018 0.0051
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0018 0.0035
Schistosoma mansoni ap endonuclease 0.0043 0.0082 0.0277
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Echinococcus multilocularis histone deacetylase 0.1129 0.2615 0.2615
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.003 0.01
Brugia malayi BRCA1-associated protein 2 containing protein 0.006 0.0123 0.0405
Brugia malayi hypothetical protein 0.0014 0.0015 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0044 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0094 0.0307
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0332 0.1114
Brugia malayi ecdysteroid receptor 0.0026 0.0044 0.0138
Onchocerca volvulus 0.0026 0.0044 0.0334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Toxoplasma gondii histone deacetylase HDAC2 0.1285 0.298 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0092
Echinococcus multilocularis histone deacetylase 3 0.1285 0.298 0.298
Loa Loa (eye worm) histone deacetylase 0.1129 0.2615 0.8775
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0082 0.9272
Loa Loa (eye worm) hypothetical protein 0.0052 0.0103 0.0337
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0044 0.0334
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.0628 0.2108
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0041
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.006 0.0123 0.0405
Mycobacterium ulcerans hypothetical protein 0.0052 0.0103 0.0195
Loa Loa (eye worm) hypothetical protein 0.0653 0.1506 0.5051
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.003 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0068 0.015
Brugia malayi hypothetical protein 0.0021 0.0031 0.0095
Echinococcus multilocularis histone deacetylase 6 0.1129 0.2615 0.2615
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0009 0.0004 0.0004
Echinococcus granulosus histone deacetylase 1 0.1285 0.298 1
Echinococcus multilocularis protein patched 0.0048 0.0094 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0044 0.0147
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0011 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0235
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0011 0.0029
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0018 0.0051
Giardia lamblia Histone deacetylase 0.1285 0.298 1
Schistosoma mansoni hypothetical protein 0.0224 0.0506 0.1698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0332 0.1114
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0082 0.0277
Onchocerca volvulus 0.0048 0.0095 0.0749
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0009 0.0003 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0072 0.0235
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0042 0.0042
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0024 0.0038 0.0119
Brugia malayi hypothetical protein 0.0021 0.0031 0.0095
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0011 0.0029
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0021 0.0032 0.0032
Toxoplasma gondii DNA methyltransferase 2, putative 0.0009 0.0004 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0082 0.0268
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0015 0.005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0018 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0092
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0009 0.0003 0.0003
Echinococcus multilocularis histone deacetylase 8 0.0536 0.1232 0.1232
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0224 0.0506 0.1691
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0044 0.0147
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0021 0.0032 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0044 0.0138
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0018 0.0035
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0091 0.0298
Echinococcus multilocularis carbonic anhydrase II 0.0376 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0138
Loa Loa (eye worm) hypothetical protein 0.0224 0.0506 0.1691
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0009 0.0003 0.0009
Trypanosoma brucei histone deacetylase 2 0.0536 0.1232 0.413
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.006 0.0123 0.0405
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.006 0.0123 0.0123
Trypanosoma cruzi histone deacetylase 1, putative 0.1285 0.298 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.006 0.0123 0.0405
Schistosoma mansoni hypothetical protein 0.0072 0.0151 0.0507
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0091 0.0298
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0024 0.0038 0.0119
Brugia malayi tailless protein 0.0012 0.0011 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0044 0.0147
Toxoplasma gondii UDP-glucose 4-epimerase 0.0024 0.0038 0.0119
Echinococcus multilocularis cpg binding protein 0.0048 0.0093 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0082 0.0268
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.006 0.0123 0.0405
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0224 0.0506 0.1691
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0044 0.0147
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1285 0.298 1
Echinococcus granulosus histone deacetylase 3 0.1285 0.298 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0092
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.006 0.0123 0.0405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0044 0.0044
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.006 0.0123 0.0405
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0044 0.0044
Loa Loa (eye worm) histone deacetylase 11 0.0536 0.1232 0.413
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0031 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0103 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0103 0.0195
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0011 0.0011
Brugia malayi UDP galactose 4'-epimerase 0.0024 0.0038 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0044 0.0138
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0094 0.0307
Brugia malayi Latrophilin receptor protein 2 0.0072 0.0151 0.0498
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0018 0.0051
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.003 0.0092
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0031 0.0095
Schistosoma mansoni hypothetical protein 0.0072 0.0151 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0068 0.015
Schistosoma mansoni hypothetical protein 0.0046 0.009 0.0302
Giardia lamblia DINP protein human, muc B family 0.002 0.003 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0044 0.0138
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0103 0.0232
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0031 0.0095
Loa Loa (eye worm) acetyltransferase 0.0173 0.0386 0.1289
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.0074 0.0239
Brugia malayi nuclear receptor NHR-88 0.0012 0.0011 0.0029
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0024 0.0038 0.0119
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0018 0.006
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0173 0.0386 0.1297
Brugia malayi conserved hypotetical protein 0.0012 0.0011 0.0029
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.006 0.0123 0.0405
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0103 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0044 0.0138
Echinococcus multilocularis tumor protein p63 0.0329 0.075 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0095
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0009 0.0003 0.0009
Schistosoma mansoni cript-related 0.0009 0.0003 0.0009
Plasmodium falciparum flap endonuclease 1 0.0025 0.0042 0.0131
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.006 0.0123 0.0405
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0103 0.0337
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0101 0.034
Schistosoma mansoni nuclear receptor 0.0012 0.0011 0.0038
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.006 0.0123 0.0405
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0414 0.0947 0.3173
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0018 0.0035
Echinococcus multilocularis traf and tnf receptor associated protein 0.0009 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0126 0.0415
Schistosoma mansoni histone deacetylase 1 2 3 0.0536 0.1232 0.4135
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.006 0.0123 0.0123
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Schistosoma mansoni hypothetical protein 0.0177 0.0396 0.1328
Echinococcus multilocularis carbonic anhydrase 0.0224 0.0506 0.0506
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0031 0.0095
Toxoplasma gondii UBA/TS-N domain-containing protein 0.006 0.0123 0.0405
Brugia malayi nuclear receptor NHR-88 0.0026 0.0044 0.0138
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0004 0.0005
Loa Loa (eye worm) oxidoreductase 0.0015 0.0018 0.0051
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.006 0.0123 0.0414
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0015 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0044 0.0138
Brugia malayi CHE-14 protein 0.0048 0.0094 0.0307
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0224 0.0506 0.1691
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0018 0.0051
Schistosoma mansoni carbonic anhydrase-related 0.0224 0.0506 0.1698
Echinococcus granulosus histone acetyltransferase KAT2B 0.0168 0.0375 0.1259
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0082 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.006 0.0123 0.0405
Plasmodium falciparum carbonic anhydrase 0.0224 0.0506 0.1691
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0018 0.0035
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0376 0.0861 0.2882
Trichomonas vaginalis BRCA1-associated protein, putative 0.006 0.0123 0.0405
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0044 0.0138
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0021 0.0032 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.006 0.0123 0.0405
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0072
Trypanosoma brucei histone deacetylase 1 0.1285 0.298 1
Echinococcus multilocularis geminin 0.0177 0.0396 0.0396
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0044 0.0147
Onchocerca volvulus 0.0015 0.0018 0.0124
Schistosoma mansoni DNA ligase IV 0.0021 0.0031 0.0103
Brugia malayi nuclear hormone receptor 0.0026 0.0044 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0029
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0011 0.0029
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Leishmania major histone deacetylase, putative 0.1285 0.298 1
Trichomonas vaginalis histone deacetylase, putative 0.1285 0.298 1
Trichomonas vaginalis brca1-associated protein, putative 0.006 0.0123 0.0405
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0072 0.0125
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.003 0.0092
Onchocerca volvulus 0.0056 0.0114 0.0907
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0159 0.0534
Brugia malayi CXXC zinc finger family protein 0.0046 0.0089 0.0291
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.006 0.0123 0.0405
Trypanosoma brucei histone deacetylase, putative 0.1129 0.2615 0.8775
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0024 0.0038 0.0119
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.003 0.0092
Toxoplasma gondii histone deacetylase HDAC1 0.1129 0.2615 0.8775
Schistosoma mansoni histone deacetylase 4 5 0.1129 0.2615 0.8776
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.002 0.0029 0.0097
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0082 0.0148
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0021 0.0032 0.0098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0086 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0044 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0011 0.0038
Brugia malayi Histone deacetylase family protein 0.1129 0.2615 0.8775
Trypanosoma cruzi histone deacetylase, putative 0.1129 0.2615 0.8775
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0103 0.0195
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0376 0.0861 0.2882
Brugia malayi steroid hormone receptor 0.0026 0.0044 0.0138
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0018 0.0051
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0156 0.0347 0.1155
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0011 0.0038

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 19.4 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 4.1078 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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